ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* regulation of ARF GTPase activity (GO:0032312)	6.28445236
2	protein targeting to Golgi (GO:0000042)	5.82728403
3	establishment of protein localization to Golgi (GO:0072600)	5.82545149
4	histone H3-K4 trimethylation (GO:0080182)	5.76319796
5	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.57762712
6	histone H3-K9 demethylation (GO:0033169)	5.18660245
7	synapsis (GO:0007129)	5.05236752
8	piRNA metabolic process (GO:0034587)	5.00605206
9	DNA methylation involved in gamete generation (GO:0043046)	5.00478334
10	mannose metabolic process (GO:0006013)	4.88831506
11	regulation of histone H3-K27 methylation (GO:0061085)	4.86861095
12	peptidyl-lysine trimethylation (GO:0018023)	4.76301886
13	male meiosis I (GO:0007141)	4.74849570
14	chromosome organization involved in meiosis (GO:0070192)	4.71820334
15	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.71716737
16	synaptonemal complex assembly (GO:0007130)	4.62830885
17	histone H4 deacetylation (GO:0070933)	4.59795116
18	protein localization to Golgi apparatus (GO:0034067)	4.56946696
19	DNA synthesis involved in DNA repair (GO:0000731)	4.41755999
20	histone H3-K4 methylation (GO:0051568)	4.36488205
21	male meiosis (GO:0007140)	4.35195982
22	phosphatidylethanolamine metabolic process (GO:0046337)	4.23704805
23	histone H3-K36 demethylation (GO:0070544)	4.22780094
24	acrosome reaction (GO:0007340)	4.21724294
25	poly(A)+ mRNA export from nucleus (GO:0016973)	4.18505077
26	sister chromatid cohesion (GO:0007062)	4.15518970
27	sperm motility (GO:0030317)	4.06284951
28	synaptonemal complex organization (GO:0070193)	4.06073857
29	meiotic nuclear division (GO:0007126)	3.86456005
30	histone H4-K16 acetylation (GO:0043984)	3.85163308
31	histone H3 deacetylation (GO:0070932)	3.81901044
32	peptidyl-lysine methylation (GO:0018022)	3.80743605
33	histone H3-K9 modification (GO:0061647)	3.78466081
34	histone lysine methylation (GO:0034968)	3.77297240
35	DNA packaging (GO:0006323)	3.73986095
36	histone lysine demethylation (GO:0070076)	3.73140092
37	chromosome condensation (GO:0030261)	3.72323169
38	histone H3-K9 methylation (GO:0051567)	3.64958326
39	histone demethylation (GO:0016577)	3.64383557
40	meiosis I (GO:0007127)	3.63634074
41	nuclear pore complex assembly (GO:0051292)	3.58381723
42	centriole replication (GO:0007099)	3.51863434
43	meiotic chromosome segregation (GO:0045132)	3.51170705
44	DNA alkylation (GO:0006305)	3.49693051
45	DNA methylation (GO:0006306)	3.49693051
46	regulation of meiosis I (GO:0060631)	3.49119791
47	spermatid development (GO:0007286)	3.47467914
48	centriole assembly (GO:0098534)	3.42091450
49	regulation of histone H3-K4 methylation (GO:0051569)	3.41556019
50	regulation of histone methylation (GO:0031060)	3.39782017
51	protein demethylation (GO:0006482)	3.38232806
52	protein dealkylation (GO:0008214)	3.38232806
53	chromatin silencing (GO:0006342)	3.34264523
54	mRNA cleavage (GO:0006379)	3.31188388
55	microtubule nucleation (GO:0007020)	3.30815842
56	motile cilium assembly (GO:0044458)	3.29537643
57	stress granule assembly (GO:0034063)	3.27887477
58	positive regulation of granulocyte differentiation (GO:0030854)	3.25509152
59	cell wall macromolecule catabolic process (GO:0016998)	3.24051591
60	single strand break repair (GO:0000012)	3.19415864
61	positive regulation of histone deacetylation (GO:0031065)	3.18858074
62	meiotic cell cycle process (GO:1903046)	3.14097360
63	maintenance of gastrointestinal epithelium (GO:0030277)	3.12103283
64	negative regulation of histone methylation (GO:0031061)	3.11381746
65	regulation of granulocyte differentiation (GO:0030852)	3.10086746
66	sperm capacitation (GO:0048240)	3.09039449
67	negative regulation of gene expression, epigenetic (GO:0045814)	3.08131908
68	snRNA processing (GO:0016180)	3.06224808
69	histone methylation (GO:0016571)	3.05297698
70	histone deubiquitination (GO:0016578)	3.03965856
71	histone H4 acetylation (GO:0043967)	3.03358653
72	histone H4-K8 acetylation (GO:0043982)	3.01996777
73	histone H4-K5 acetylation (GO:0043981)	3.01996777
74	positive regulation of Rab GTPase activity (GO:0032851)	3.01432415
75	regulation of Rab GTPase activity (GO:0032313)	3.01432415
76	sperm-egg recognition (GO:0035036)	2.97725677
77	histone acetylation (GO:0016573)	2.96725534
78	intra-Golgi vesicle-mediated transport (GO:0006891)	2.96492106
79	positive regulation of protein kinase C signaling (GO:0090037)	2.95666639
80	rRNA methylation (GO:0031167)	2.94242192
81	nucleosome disassembly (GO:0006337)	2.91820620
82	protein-DNA complex disassembly (GO:0032986)	2.91820620
83	snRNA metabolic process (GO:0016073)	2.91490416
84	epithelial structure maintenance (GO:0010669)	2.91308622
85	gene silencing (GO:0016458)	2.86828142
86	negative regulation of granulocyte differentiation (GO:0030853)	2.84893978
87	internal peptidyl-lysine acetylation (GO:0018393)	2.83635341
88	positive regulation of gene expression, epigenetic (GO:0045815)	2.81773751
89	mRNA splice site selection (GO:0006376)	2.79965016
90	reciprocal DNA recombination (GO:0035825)	2.78998723
91	reciprocal meiotic recombination (GO:0007131)	2.78998723
92	cell-cell recognition (GO:0009988)	2.78369222
93	N-terminal protein amino acid acetylation (GO:0006474)	2.77613227
94	cilium or flagellum-dependent cell motility (GO:0001539)	2.73329788
95	peptidyl-lysine acetylation (GO:0018394)	2.72987511
96	rRNA catabolic process (GO:0016075)	2.72878924
97	mast cell activation involved in immune response (GO:0002279)	2.72145366
98	mast cell degranulation (GO:0043303)	2.72145366
99	nuclear pore organization (GO:0006999)	2.71667733
100	regulation of cilium movement (GO:0003352)	2.71137449

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	3.51026946
2	E2F7_22180533_ChIP-Seq_HELA_Human	2.78622567
3	CIITA_25753668_ChIP-Seq_RAJI_Human	2.55854754
4	MYC_22102868_ChIP-Seq_BL_Human	2.52944369
5	MAF_26560356_Chip-Seq_TH2_Human	2.37139694
6	SMC4_20622854_ChIP-Seq_HELA_Human	2.22260572
7	P68_20966046_ChIP-Seq_HELA_Human	2.17133992
8	VDR_21846776_ChIP-Seq_THP-1_Human	2.13048518
9	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.12108366
10	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	2.10305181
11	PHF8_20622854_ChIP-Seq_HELA_Human	2.04728857
12	KDM2B_26808549_Chip-Seq_DND41_Human	2.03856076
13	E2F1_20622854_ChIP-Seq_HELA_Human	1.98149244
14	BCL6_27268052_Chip-Seq_Bcells_Human	1.91451287
15	BCOR_27268052_Chip-Seq_Bcells_Human	1.91087422
16	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.89530272
17	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.87002213
18	TCF7_22412390_ChIP-Seq_EML_Mouse	1.85304540
19	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.81004963
20	ERA_21632823_ChIP-Seq_H3396_Human	1.79794131
21	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.78335454
22	DROSHA_22980978_ChIP-Seq_HELA_Human	1.76067428
23	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.73705971
24	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.72558312
25	KDM5A_27292631_Chip-Seq_BREAST_Human	1.71883156
26	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.67515095
27	UTX_26944678_Chip-Seq_JUKART_Human	1.65225714
28	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.63941733
29	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.63656408
30	NCOR1_26117541_ChIP-Seq_K562_Human	1.63202417
31	LXR_22292898_ChIP-Seq_THP-1_Human	1.62556384
32	SPI1_23127762_ChIP-Seq_K562_Human	1.62284866
33	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.61622401
34	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.60189650
35	MYB_26560356_Chip-Seq_TH1_Human	1.58765278
36	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.58701577
37	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.52907107
38	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.52831581
39	OCT4_19829295_ChIP-Seq_ESCs_Human	1.52659926
40	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.52479253
41	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.51331592
42	MAF_26560356_Chip-Seq_TH1_Human	1.51039068
43	CTCF_27219007_Chip-Seq_Bcells_Human	1.50646136
44	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.49082881
45	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.47650327
46	SA1_27219007_Chip-Seq_Bcells_Human	1.46997026
47	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.44565873
48	RAC3_21632823_ChIP-Seq_H3396_Human	1.43647702
49	MYB_26560356_Chip-Seq_TH2_Human	1.40650232
50	CREB1_26743006_Chip-Seq_LNCaP_Human	1.39457665
51	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.36738297
52	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.36418292
53	GATA3_27048872_Chip-Seq_THYMUS_Human	1.34354789
54	P300_27268052_Chip-Seq_Bcells_Human	1.34094910
55	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.34031431
56	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.33601475
57	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.33310136
58	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.32125881
59	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.31394802
60	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30731382
61	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30412132
62	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.30230748
63	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.29665127
64	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.29647074
65	KDM2B_26808549_Chip-Seq_K562_Human	1.26474779
66	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.26393288
67	GABP_19822575_ChIP-Seq_HepG2_Human	1.26130896
68	OCT4_20526341_ChIP-Seq_ESCs_Human	1.25921723
69	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.23177838
70	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.22491860
71	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	1.21976966
72	SCL_19346495_ChIP-Seq_HPC-7_Human	1.20641251
73	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.19750671
74	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.18860334
75	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.18691943
76	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.18100110
77	TP63_22573176_ChIP-Seq_HFKS_Human	1.16948279
78	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.16779999
79	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.16284134
80	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.16210600
81	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.15354464
82	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.13642250
83	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.13274636
84	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.11789653
85	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10984263
86	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.10386674
87	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.05511616
88	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.04794803
89	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.04500249
90	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03997731
91	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.03401038
92	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.03207005
93	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.03077998
94	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.02273499
95	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.01701778
96	CTCF_20526341_ChIP-Seq_ESCs_Human	1.00915653
97	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.99799772
98	CTCF_21964334_Chip-Seq_Bcells_Human	0.99005620
99	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.98699702
100	SPI1_23547873_ChIP-Seq_NB4_Human	0.98142632

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.87388101
2	MP0005410_abnormal_fertilization	3.76190308
3	MP0003172_abnormal_lysosome_physiology	3.30692869
4	MP0008058_abnormal_DNA_repair	2.95737882
5	MP0001929_abnormal_gametogenesis	2.75239793
6	MP0008995_early_reproductive_senescence	2.69230274
7	MP0003698_abnormal_male_reproductive	2.62189260
8	MP0000678_abnormal_parathyroid_gland	2.58850180
9	MP0002396_abnormal_hematopoietic_system	2.46710907
10	MP0008057_abnormal_DNA_replication	2.34518707
11	MP0003111_abnormal_nucleus_morphology	2.19644988
12	MP0002210_abnormal_sex_determination	2.19435351
13	MP0010094_abnormal_chromosome_stability	2.02481768
14	MP0003646_muscle_fatigue	1.92520324
15	MP0003763_abnormal_thymus_physiology	1.90998196
16	MP0005451_abnormal_body_composition	1.88889704
17	MP0008004_abnormal_stomach_pH	1.86349409
18	MP0001145_abnormal_male_reproductive	1.76918365
19	MP0000703_abnormal_thymus_morphology	1.74919741
20	MP0002132_abnormal_respiratory_system	1.74904620
21	MP0002249_abnormal_larynx_morphology	1.68957043
22	MP0001270_distended_abdomen	1.67864169
23	MP0003786_premature_aging	1.65867178
24	MP0006035_abnormal_mitochondrial_morpho	1.64893070
25	MP0000653_abnormal_sex_gland	1.60037811
26	MP0003878_abnormal_ear_physiology	1.59936647
27	MP0005377_hearing/vestibular/ear_phenot	1.59936647
28	MP0010307_abnormal_tumor_latency	1.59852265
29	MP0004808_abnormal_hematopoietic_stem	1.59244510
30	MP0005310_abnormal_salivary_gland	1.57636219
31	MP0003693_abnormal_embryo_hatching	1.55919047
32	MP0003436_decreased_susceptibility_to	1.54185332
33	MP0005397_hematopoietic_system_phenotyp	1.48651031
34	MP0001545_abnormal_hematopoietic_system	1.48651031
35	MP0001800_abnormal_humoral_immune	1.47954759
36	MP0001873_stomach_inflammation	1.46822958
37	MP0002138_abnormal_hepatobiliary_system	1.46424087
38	MP0009278_abnormal_bone_marrow	1.46335841
39	MP0003656_abnormal_erythrocyte_physiolo	1.41941973
40	MP0003787_abnormal_imprinting	1.41843544
41	MP0002161_abnormal_fertility/fecundity	1.38374884
42	MP0006036_abnormal_mitochondrial_physio	1.36105277
43	MP0001348_abnormal_lacrimal_gland	1.34317883
44	MP0002398_abnormal_bone_marrow	1.32827540
45	MP0005058_abnormal_lysosome_morphology	1.29495953
46	MP0004043_abnormal_pH_regulation	1.27471644
47	MP0002722_abnormal_immune_system	1.21546779
48	MP0005076_abnormal_cell_differentiation	1.16411614
49	MP0003077_abnormal_cell_cycle	1.16385546
50	MP0005394_taste/olfaction_phenotype	1.14492524
51	MP0005499_abnormal_olfactory_system	1.14492524
52	MP0002723_abnormal_immune_serum	1.11949635
53	MP0001730_embryonic_growth_arrest	1.11004980
54	MP0008007_abnormal_cellular_replicative	1.10895875
55	MP0002269_muscular_atrophy	1.09035205
56	MP0002420_abnormal_adaptive_immunity	1.03957859
57	MP0003123_paternal_imprinting	1.03922941
58	MP0000313_abnormal_cell_death	1.03265949
59	MP0000716_abnormal_immune_system	1.02995289
60	MP0001819_abnormal_immune_cell	1.02150745
61	MP0000689_abnormal_spleen_morphology	1.01654865
62	MP0005671_abnormal_response_to	1.01311773
63	MP0001790_abnormal_immune_system	1.00986980
64	MP0005387_immune_system_phenotype	1.00986980
65	MP0000015_abnormal_ear_pigmentation	0.99840435
66	MP0008260_abnormal_autophagy	0.99816373
67	MP0002405_respiratory_system_inflammati	0.97838599
68	MP0001661_extended_life_span	0.97087268
69	MP0005083_abnormal_biliary_tract	0.94575094
70	MP0009115_abnormal_fat_cell	0.94022283
71	MP0001764_abnormal_homeostasis	0.94009528
72	MP0001835_abnormal_antigen_presentation	0.93765430
73	MP0005409_darkened_coat_color	0.93460449
74	MP0005025_abnormal_response_to	0.92414702
75	MP0003866_abnormal_defecation	0.91053956
76	MP0001119_abnormal_female_reproductive	0.89753217
77	MP0009840_abnormal_foam_cell	0.87977549
78	MP0010155_abnormal_intestine_physiology	0.87197505
79	MP0003943_abnormal_hepatobiliary_system	0.87005583
80	MP0003252_abnormal_bile_duct	0.86942921
81	MP0002429_abnormal_blood_cell	0.86516381
82	MP0002970_abnormal_white_adipose	0.86495523
83	MP0003300_gastrointestinal_ulcer	0.84327894
84	MP0002452_abnormal_antigen_presenting	0.82930719
85	MP0000749_muscle_degeneration	0.81372815
86	MP0004381_abnormal_hair_follicle	0.81261392
87	MP0008789_abnormal_olfactory_epithelium	0.80911654
88	MP0004233_abnormal_muscle_weight	0.78942996
89	MP0003699_abnormal_female_reproductive	0.76643170
90	MP0002019_abnormal_tumor_incidence	0.75641507
91	MP0005000_abnormal_immune_tolerance	0.73996623
92	MP0009703_decreased_birth_body	0.73992195
93	MP0001697_abnormal_embryo_size	0.68721896
94	MP0003121_genomic_imprinting	0.67427613
95	MP0004197_abnormal_fetal_growth/weight/	0.65755736
96	MP0005670_abnormal_white_adipose	0.64755347
97	MP0004742_abnormal_vestibular_system	0.63134556
98	MP0002419_abnormal_innate_immunity	0.62552539
99	MP0009785_altered_susceptibility_to	0.61992880
100	MP0004264_abnormal_extraembryonic_tissu	0.58292957

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	6.30157832
2	Abnormality of the fingertips (HP:0001211)	4.61292641
3	Abnormality of DNA repair (HP:0003254)	3.64200808
4	Tubulointerstitial nephritis (HP:0001970)	3.62318435
5	Abnormality of lateral ventricle (HP:0030047)	3.61129088
6	Ectopic kidney (HP:0000086)	3.39538740
7	Chromsome breakage (HP:0040012)	3.27960218
8	Seborrheic dermatitis (HP:0001051)	3.15938249
9	Facial hemangioma (HP:0000329)	3.12901866
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.05674460
11	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.02560964
12	Hypoplastic ischia (HP:0003175)	2.80448157
13	Truncal obesity (HP:0001956)	2.75303345
14	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.63730761
15	Abnormality of the aortic arch (HP:0012303)	2.63451309
16	Bony spicule pigmentary retinopathy (HP:0007737)	2.63151184
17	Atelectasis (HP:0100750)	2.61136348
18	Scotoma (HP:0000575)	2.58858345
19	Ependymoma (HP:0002888)	2.55951349
20	Metaphyseal cupping (HP:0003021)	2.50165532
21	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.48637077
22	Male infertility (HP:0003251)	2.47984021
23	Long eyelashes (HP:0000527)	2.47213536
24	Abnormal hair whorl (HP:0010721)	2.46718181
25	Hyperkalemia (HP:0002153)	2.44533021
26	Bowel incontinence (HP:0002607)	2.38238681
27	Chronic hepatic failure (HP:0100626)	2.38036316
28	Long clavicles (HP:0000890)	2.35006540
29	Thoracic kyphosis (HP:0002942)	2.30791226
30	Truncus arteriosus (HP:0001660)	2.29753443
31	Hypoplastic iliac wings (HP:0002866)	2.28158963
32	Thin bony cortex (HP:0002753)	2.24900623
33	Impulsivity (HP:0100710)	2.23675957
34	Basal cell carcinoma (HP:0002671)	2.21472485
35	Obstructive sleep apnea (HP:0002870)	2.21303205
36	Cystic liver disease (HP:0006706)	2.20723961
37	Panhypogammaglobulinemia (HP:0003139)	2.20406029
38	Heterotopia (HP:0002282)	2.19964867
39	Abnormal large intestine physiology (HP:0012700)	2.16609376
40	Volvulus (HP:0002580)	2.16408376
41	Duplicated collecting system (HP:0000081)	2.12503432
42	Clubbing of toes (HP:0100760)	2.07468242
43	Hyperthyroidism (HP:0000836)	2.07403758
44	Abnormality of the thoracic spine (HP:0100711)	2.05993259
45	Central scotoma (HP:0000603)	2.05683640
46	Abnormality of cochlea (HP:0000375)	2.04454601
47	Abnormality of chloride homeostasis (HP:0011422)	2.04203130
48	Abnormality of the renal medulla (HP:0100957)	2.02909168
49	Abnormality of the ischium (HP:0003174)	2.02757225
50	Colitis (HP:0002583)	2.02223600
51	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.02140275
52	Nephronophthisis (HP:0000090)	2.01012909
53	Molar tooth sign on MRI (HP:0002419)	1.99094541
54	Abnormality of midbrain morphology (HP:0002418)	1.99094541
55	Sloping forehead (HP:0000340)	1.97898361
56	Abnormality of macular pigmentation (HP:0008002)	1.97723018
57	Stridor (HP:0010307)	1.97165523
58	Hand muscle atrophy (HP:0009130)	1.93021320
59	Obsessive-compulsive behavior (HP:0000722)	1.92431963
60	Distal upper limb amyotrophy (HP:0007149)	1.91893990
61	Upper limb amyotrophy (HP:0009129)	1.91893990
62	Cafe-au-lait spot (HP:0000957)	1.91840005
63	Sandal gap (HP:0001852)	1.91435822
64	Polycystic kidney dysplasia (HP:0000113)	1.90692606
65	Squamous cell carcinoma (HP:0002860)	1.89651290
66	Occipital encephalocele (HP:0002085)	1.89480625
67	Bell-shaped thorax (HP:0001591)	1.89135002
68	Abnormality of the renal collecting system (HP:0004742)	1.84394694
69	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.84265514
70	Gastrointestinal inflammation (HP:0004386)	1.83468550
71	Narrow palate (HP:0000189)	1.83315632
72	Abnormality of pyrimidine metabolism (HP:0004353)	1.81342703
73	Optic nerve coloboma (HP:0000588)	1.80093084
74	Abnormality of the labia minora (HP:0012880)	1.78867624
75	Clumsiness (HP:0002312)	1.77744697
76	Cerebellar dysplasia (HP:0007033)	1.75852880
77	Abnormality of the columella (HP:0009929)	1.75837214
78	Neoplasm of striated muscle (HP:0009728)	1.75635273
79	Obstructive lung disease (HP:0006536)	1.75106372
80	Chronic obstructive pulmonary disease (HP:0006510)	1.75106372
81	Neurodegeneration (HP:0002180)	1.74741996
82	Self-mutilation (HP:0000742)	1.74656429
83	Capillary hemangiomas (HP:0005306)	1.73962352
84	Granulocytopenia (HP:0001913)	1.72738853
85	Abnormality of the preputium (HP:0100587)	1.72233721
86	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.71896647
87	Abnormality of the femoral head (HP:0003368)	1.71226197
88	Ankle clonus (HP:0011448)	1.68002007
89	Urethral obstruction (HP:0000796)	1.67767410
90	Attenuation of retinal blood vessels (HP:0007843)	1.66543763
91	Deep palmar crease (HP:0006191)	1.66465475
92	Inflammation of the large intestine (HP:0002037)	1.64451344
93	Cerebral aneurysm (HP:0004944)	1.63283536
94	Dislocated radial head (HP:0003083)	1.61461990
95	Broad palm (HP:0001169)	1.60838389
96	Abnormality of incisor morphology (HP:0011063)	1.60355925
97	Broad alveolar ridges (HP:0000187)	1.58916962
98	Type II lissencephaly (HP:0007260)	1.58054994
99	Low anterior hairline (HP:0000294)	1.57055104
100	Abnormality of chromosome stability (HP:0003220)	1.55287128

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME1	3.22001149
2	MST1R	2.77326187
3	MAP3K7	2.76225037
4	SIK2	2.74970577
5	CDK12	2.67629840
6	BRD4	2.65701419
7	TNK2	2.43827874
8	PLK4	2.35242485
9	MARK3	2.26435547
10	RIPK4	2.11444991
11	MAP3K13	2.06298064
12	TRIB3	1.90283034
13	MAP2K6	1.84722691
14	SIK3	1.83429853
15	MAP4K1	1.81492789
16	WNK4	1.79916302
17	NTRK3	1.66958412
18	CAMK1G	1.65494090
19	KSR2	1.62584442
20	STK38	1.43867391
21	MET	1.42867324
22	SIK1	1.41890026
23	MARK2	1.41376453
24	WNK1	1.39421190
25	BLK	1.37101273
26	BMX	1.35674160
27	PRKD2	1.30673676
28	TYK2	1.28230825
29	ERN1	1.27773508
30	MAP2K3	1.26582410
31	MAP3K9	1.22627543
32	CDK3	1.20720008
33	TYRO3	1.15183737
34	BTK	1.14751046
35	CHEK1	1.14164399
36	CDK19	1.14152709
37	MTOR	1.08132961
38	ATR	1.06305859
39	CDC42BPA	1.02699371
40	TXK	1.02347818
41	ICK	0.97721208
42	FGFR4	0.97362176
43	PTK2B	0.96090439
44	CAMK1D	0.95942588
45	INSRR	0.94990738
46	CDK4	0.94798770
47	FRK	0.91295513
48	FGR	0.89936163
49	PDK1	0.87291385
50	PDPK1	0.87154572
51	PINK1	0.79951562
52	PRKAA1	0.79360816
53	PRKAA2	0.77115049
54	RET	0.75588716
55	ITK	0.75272304
56	PNCK	0.74515769
57	PASK	0.71407780
58	RPS6KA2	0.69996866
59	PKN2	0.68537636
60	CDK2	0.68292717
61	JAK3	0.66923991
62	KSR1	0.66176385
63	RPS6KC1	0.65333020
64	RPS6KL1	0.65333020
65	ZAP70	0.64740599
66	CDK9	0.64613029
67	FGFR3	0.63282699
68	MAP3K1	0.62775649
69	ATM	0.62499510
70	JAK2	0.60224136
71	MAPK1	0.57606746
72	SGK1	0.57154020
73	HCK	0.56537577
74	IRAK4	0.56010401
75	CDK1	0.55100301
76	RPS6KA6	0.54363390
77	PDGFRB	0.54042819
78	RPS6KA4	0.53323321
79	PRKD3	0.53308016
80	GSK3B	0.53189951
81	SGK3	0.52464460
82	MAPK11	0.52211447
83	GRK6	0.51979935
84	EEF2K	0.51568704
85	DDR2	0.51254688
86	MAPK8	0.49364396
87	CAMK1	0.48231698
88	HIPK2	0.48190164
89	PRKCH	0.47800543
90	NEK2	0.47608890
91	ERBB2	0.47550416
92	IRAK2	0.45367561
93	MAP3K2	0.44878168
94	TAOK1	0.44625035
95	MAP3K14	0.43904148
96	MKNK2	0.43779838
97	MAP3K6	0.43374148
98	MAPK10	0.43342529
99	STK11	0.42884360
100	OXSR1	0.42182060

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Other glycan degradation_Homo sapiens_hsa00511	3.01202246
2	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.42624332
3	Lysine degradation_Homo sapiens_hsa00310	2.37456399
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.34892221
5	Homologous recombination_Homo sapiens_hsa03440	2.23967327
6	mRNA surveillance pathway_Homo sapiens_hsa03015	2.04913106
7	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.97449912
8	Non-homologous end-joining_Homo sapiens_hsa03450	1.91565367
9	Butanoate metabolism_Homo sapiens_hsa00650	1.81457435
10	Acute myeloid leukemia_Homo sapiens_hsa05221	1.80909137
11	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.75557297
12	RNA transport_Homo sapiens_hsa03013	1.74404223
13	Basal transcription factors_Homo sapiens_hsa03022	1.71145874
14	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.69433565
15	mTOR signaling pathway_Homo sapiens_hsa04150	1.59767827
16	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.57913704
17	Herpes simplex infection_Homo sapiens_hsa05168	1.57590421
18	Choline metabolism in cancer_Homo sapiens_hsa05231	1.57221050
19	Notch signaling pathway_Homo sapiens_hsa04330	1.56236620
20	ABC transporters_Homo sapiens_hsa02010	1.56090160
21	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.53475011
22	Oocyte meiosis_Homo sapiens_hsa04114	1.41804743
23	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.41354779
24	Base excision repair_Homo sapiens_hsa03410	1.37079396
25	Regulation of autophagy_Homo sapiens_hsa04140	1.36699870
26	Influenza A_Homo sapiens_hsa05164	1.36612987
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.36580110
28	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.36307279
29	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.32827384
30	VEGF signaling pathway_Homo sapiens_hsa04370	1.26785625
31	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.25352946
32	Olfactory transduction_Homo sapiens_hsa04740	1.21071021
33	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.19892168
34	Type II diabetes mellitus_Homo sapiens_hsa04930	1.17103771
35	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.16886983
36	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.16119601
37	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.15119243
38	Measles_Homo sapiens_hsa05162	1.08930344
39	TNF signaling pathway_Homo sapiens_hsa04668	1.08310221
40	Osteoclast differentiation_Homo sapiens_hsa04380	1.05028430
41	Hepatitis C_Homo sapiens_hsa05160	1.03317199
42	Insulin resistance_Homo sapiens_hsa04931	1.02366927
43	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.01709276
44	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.01477243
45	Non-small cell lung cancer_Homo sapiens_hsa05223	0.98441663
46	Spliceosome_Homo sapiens_hsa03040	0.95843431
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.94964617
48	Prolactin signaling pathway_Homo sapiens_hsa04917	0.94520904
49	Hepatitis B_Homo sapiens_hsa05161	0.93727434
50	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.92453143
51	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.91692013
52	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.91236255
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88200471
54	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.85293901
55	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.83948035
56	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.80747465
57	ErbB signaling pathway_Homo sapiens_hsa04012	0.80357383
58	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.80042442
59	Insulin signaling pathway_Homo sapiens_hsa04910	0.79581842
60	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.78242139
61	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.77356040
62	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.75867589
63	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.71155767
64	Prostate cancer_Homo sapiens_hsa05215	0.70782122
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70502196
66	DNA replication_Homo sapiens_hsa03030	0.68434322
67	FoxO signaling pathway_Homo sapiens_hsa04068	0.65537757
68	Circadian rhythm_Homo sapiens_hsa04710	0.65049771
69	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.64810621
70	Glucagon signaling pathway_Homo sapiens_hsa04922	0.64765650
71	Cell cycle_Homo sapiens_hsa04110	0.64360132
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.62302408
73	AMPK signaling pathway_Homo sapiens_hsa04152	0.60465977
74	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.59674225
75	HTLV-I infection_Homo sapiens_hsa05166	0.59629477
76	MAPK signaling pathway_Homo sapiens_hsa04010	0.58807353
77	Nucleotide excision repair_Homo sapiens_hsa03420	0.57503728
78	Toxoplasmosis_Homo sapiens_hsa05145	0.57296613
79	GnRH signaling pathway_Homo sapiens_hsa04912	0.55986792
80	Endometrial cancer_Homo sapiens_hsa05213	0.55556396
81	Pancreatic cancer_Homo sapiens_hsa05212	0.52621265
82	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.52489751
83	Allograft rejection_Homo sapiens_hsa05330	0.50856787
84	Graft-versus-host disease_Homo sapiens_hsa05332	0.50745689
85	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.49749046
86	Type I diabetes mellitus_Homo sapiens_hsa04940	0.48856724
87	Apoptosis_Homo sapiens_hsa04210	0.48269495
88	RNA degradation_Homo sapiens_hsa03018	0.47660229
89	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.47029061
90	Leishmaniasis_Homo sapiens_hsa05140	0.46423133
91	Taste transduction_Homo sapiens_hsa04742	0.44794865
92	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.44516891
93	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.41802492
94	Chemokine signaling pathway_Homo sapiens_hsa04062	0.41618122
95	Glioma_Homo sapiens_hsa05214	0.41524373
96	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.41316136
97	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.40969046
98	Colorectal cancer_Homo sapiens_hsa05210	0.39303238
99	One carbon pool by folate_Homo sapiens_hsa00670	0.39141379
100	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.38382820

AGAP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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