AGAP7P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.67449172
2cellular extravasation (GO:0045123)5.63575366
3positive regulation of gamma-delta T cell activation (GO:0046645)5.32674284
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.24031349
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.24031349
6modulation by symbiont of host immune response (GO:0052553)5.24031349
7positive regulation by symbiont of host defense response (GO:0052509)5.24031349
8modulation by symbiont of host defense response (GO:0052031)5.24031349
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.24031349
10regulation of B cell receptor signaling pathway (GO:0050855)5.07822856
11negative regulation of cell killing (GO:0031342)5.06418760
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.06418760
13neutrophil activation involved in immune response (GO:0002283)5.00552242
14neutrophil mediated immunity (GO:0002446)4.70045889
15regulation of memory T cell differentiation (GO:0043380)4.49117288
16neutrophil activation (GO:0042119)4.48232251
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.46451814
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.36684263
19detection of molecule of bacterial origin (GO:0032490)4.32481279
20antigen processing and presentation of endogenous antigen (GO:0019883)4.29329667
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.18669450
22macrophage activation involved in immune response (GO:0002281)4.04561995
23leukocyte degranulation (GO:0043299)4.02478315
24regulation of gamma-delta T cell activation (GO:0046643)3.95967124
25mast cell degranulation (GO:0043303)3.95188213
26mast cell activation involved in immune response (GO:0002279)3.95188213
27positive regulation of B cell differentiation (GO:0045579)3.93607920
28regulation of B cell differentiation (GO:0045577)3.92615912
29* regulation of ARF GTPase activity (GO:0032312)3.90508948
30negative regulation of type 2 immune response (GO:0002829)3.90181644
31detection of other organism (GO:0098543)3.89955767
32granulocyte activation (GO:0036230)3.86202830
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.84659628
34phosphatidylethanolamine biosynthetic process (GO:0006646)3.83982636
35response to interleukin-15 (GO:0070672)3.83807308
36myeloid leukocyte mediated immunity (GO:0002444)3.81383206
37myeloid cell activation involved in immune response (GO:0002275)3.80993421
38respiratory burst (GO:0045730)3.80701981
39negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.80543090
40microglial cell activation (GO:0001774)3.79222406
41cellular response to interleukin-15 (GO:0071350)3.77919340
42regulation of gamma-delta T cell differentiation (GO:0045586)3.77896176
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.76767659
44leukocyte aggregation (GO:0070486)3.75148049
45leukocyte migration involved in inflammatory response (GO:0002523)3.74742093
46detection of external biotic stimulus (GO:0098581)3.74239941
47detection of bacterium (GO:0016045)3.54021026
48response to peptidoglycan (GO:0032494)3.53225784
49phosphatidylethanolamine metabolic process (GO:0046337)3.51887304
50mast cell activation (GO:0045576)3.50487212
51negative regulation of phagocytosis (GO:0050765)3.48989721
52negative regulation of cAMP-mediated signaling (GO:0043951)3.42817204
53positive regulation of T cell mediated cytotoxicity (GO:0001916)3.39202535
54response to host immune response (GO:0052572)3.33088355
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.33088355
56detection of biotic stimulus (GO:0009595)3.32895465
57B cell receptor signaling pathway (GO:0050853)3.30861726
58regulation of mast cell activation (GO:0033003)3.29374898
59regulation of interferon-beta biosynthetic process (GO:0045357)3.27138478
60macrophage activation (GO:0042116)3.24398941
61negative regulation of T-helper cell differentiation (GO:0045623)3.21622822
62negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.21622822
63positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.21316300
64regulation of MHC class I biosynthetic process (GO:0045343)3.19587567
65negative regulation of interleukin-12 production (GO:0032695)3.16425373
66killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.08817183
67disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.08817183
68negative regulation of interleukin-1 production (GO:0032692)3.03665419
69regulation of mast cell degranulation (GO:0043304)3.02944061
70negative regulation of leukocyte mediated immunity (GO:0002704)3.01102933
71dendritic cell chemotaxis (GO:0002407)3.00130394
72regulation of T cell mediated cytotoxicity (GO:0001914)3.00042520
73dendritic cell migration (GO:0036336)2.97364628
74activated T cell proliferation (GO:0050798)2.95573245
75positive regulation of mast cell activation (GO:0033005)2.95046453
76production of molecular mediator involved in inflammatory response (GO:0002532)2.94705571
77regulation of mast cell activation involved in immune response (GO:0033006)2.93225175
78regulation of interleukin-13 production (GO:0032656)2.90350553
79regulation of regulatory T cell differentiation (GO:0045589)2.90290510
80response to type I interferon (GO:0034340)2.90284829
81cellular response to type I interferon (GO:0071357)2.89769107
82type I interferon signaling pathway (GO:0060337)2.89769107
83regulation of T-helper 2 cell differentiation (GO:0045628)2.88316785
84response to host (GO:0075136)2.87376832
85response to host defenses (GO:0052200)2.87376832
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.87376832
87positive regulation of granulocyte differentiation (GO:0030854)2.86801687
88negative thymic T cell selection (GO:0045060)2.86795824
89regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.81405481
90negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.80054689
91defense response to protozoan (GO:0042832)2.79611660
92negative regulation of T cell mediated immunity (GO:0002710)2.78484192
93negative regulation of alpha-beta T cell activation (GO:0046636)2.77289860
94negative T cell selection (GO:0043383)2.75235998
95regulation of interleukin-6 biosynthetic process (GO:0045408)2.73876419
96regulation of alpha-beta T cell proliferation (GO:0046640)2.73120093
97regulation of T cell tolerance induction (GO:0002664)2.69931247
98regulation of tolerance induction (GO:0002643)2.69237534
99tolerance induction (GO:0002507)2.68655757
100negative regulation of interleukin-1 beta production (GO:0032691)2.66319456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.93940441
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.31514802
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.08557870
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.16064979
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82099203
6ZNF274_21170338_ChIP-Seq_K562_Hela2.58749874
7RUNX_20019798_ChIP-Seq_JUKART_Human2.52656157
8MYB_26560356_Chip-Seq_TH2_Human2.52234080
9SPI1_23547873_ChIP-Seq_NB4_Human2.47771637
10SCL_19346495_ChIP-Seq_HPC-7_Human2.32712005
11SPI1_23127762_ChIP-Seq_K562_Human2.27670433
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25442912
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.24000413
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20596849
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.13126196
16ER_23166858_ChIP-Seq_MCF-7_Human2.00929158
17GATA3_27048872_Chip-Seq_THYMUS_Human2.00693380
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.97190503
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95814484
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93856653
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93366455
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92986183
23MYB_26560356_Chip-Seq_TH1_Human1.92069200
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91924636
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91725188
26VDR_24763502_ChIP-Seq_THP-1_Human1.85069542
27UTX_26944678_Chip-Seq_JUKART_Human1.77805487
28GATA3_26560356_Chip-Seq_TH2_Human1.75100531
29VDR_24787735_ChIP-Seq_THP-1_Human1.71905571
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68714534
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68051958
32MAF_26560356_Chip-Seq_TH2_Human1.66272212
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63634252
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63255635
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60664802
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60607385
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57630825
38VDR_21846776_ChIP-Seq_THP-1_Human1.57102115
39MAF_26560356_Chip-Seq_TH1_Human1.55419202
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.46182308
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34472952
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33500274
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33014420
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32648780
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32592257
46OCT4_20526341_ChIP-Seq_ESCs_Human1.31329370
47GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29778099
48GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29717556
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29190812
50IGF1R_20145208_ChIP-Seq_DFB_Human1.29042701
51NANOG_20526341_ChIP-Seq_ESCs_Human1.28354094
52ERA_21632823_ChIP-Seq_H3396_Human1.27722408
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27497840
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25129561
55BCL6_27268052_Chip-Seq_Bcells_Human1.23654186
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23203050
57IRF1_19129219_ChIP-ChIP_H3396_Human1.21812780
58TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21463232
59VDR_22108803_ChIP-Seq_LS180_Human1.21015561
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20306163
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19006275
62WDR5_24793694_ChIP-Seq_LNCAP_Human1.18982670
63SMRT_27268052_Chip-Seq_Bcells_Human1.18303112
64RAC3_21632823_ChIP-Seq_H3396_Human1.18052158
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17494341
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.17208036
67TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.17183408
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17049596
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16597915
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15997685
71P300_27268052_Chip-Seq_Bcells_Human1.14927851
72BCAT_22108803_ChIP-Seq_LS180_Human1.13362566
73SPI1_20517297_ChIP-Seq_HL60_Human1.12789468
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11898798
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11898798
76E2F1_20622854_ChIP-Seq_HELA_Human1.11564257
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09256265
78PHF8_20622854_ChIP-Seq_HELA_Human1.08961136
79GATA3_21878914_ChIP-Seq_MCF-7_Human1.08930451
80GATA3_26560356_Chip-Seq_TH1_Human1.08377000
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.06867677
82RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05234949
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04246808
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04114104
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03232632
86KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00108643
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98417299
88BCOR_27268052_Chip-Seq_Bcells_Human0.98330665
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97406749
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97318333
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92822329
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92011575
93GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91239085
94OCT1_27270436_Chip-Seq_PROSTATE_Human0.90526998
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.88818184
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88743152
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88613440
98DROSHA_22980978_ChIP-Seq_HELA_Human0.88005765
99GBX2_23144817_ChIP-Seq_PC3_Human0.87835623
100RXR_22108803_ChIP-Seq_LS180_Human0.87769154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.78640692
2MP0002132_abnormal_respiratory_system3.62378196
3MP0003436_decreased_susceptibility_to3.30332359
4MP0002419_abnormal_innate_immunity2.83180808
5MP0001835_abnormal_antigen_presentation2.75915960
6MP0001800_abnormal_humoral_immune2.64005110
7MP0004381_abnormal_hair_follicle2.50968843
8MP0002396_abnormal_hematopoietic_system2.50489440
9MP0005025_abnormal_response_to2.46811796
10MP0005671_abnormal_response_to2.36257559
11MP0002420_abnormal_adaptive_immunity2.34826643
12MP0002723_abnormal_immune_serum2.32874624
13MP0001819_abnormal_immune_cell2.32361319
14MP0003303_peritoneal_inflammation2.29247041
15MP0005000_abnormal_immune_tolerance2.26257575
16MP0009785_altered_susceptibility_to2.23552840
17MP0005410_abnormal_fertilization2.23406854
18MP0003011_delayed_dark_adaptation2.14423168
19MP0002452_abnormal_antigen_presenting2.12164313
20MP0002405_respiratory_system_inflammati1.92214431
21MP0003763_abnormal_thymus_physiology1.91535819
22MP0001790_abnormal_immune_system1.91336163
23MP0005387_immune_system_phenotype1.91336163
24MP0001986_abnormal_taste_sensitivity1.87445560
25MP0002277_abnormal_respiratory_mucosa1.86258023
26MP0009764_decreased_sensitivity_to1.82834796
27MP0002398_abnormal_bone_marrow1.80143229
28MP0000716_abnormal_immune_system1.79251851
29MP0008877_abnormal_DNA_methylation1.76937160
30MP0000685_abnormal_immune_system1.76844917
31MP0003878_abnormal_ear_physiology1.76674082
32MP0005377_hearing/vestibular/ear_phenot1.76674082
33MP0009278_abnormal_bone_marrow1.76604055
34MP0002722_abnormal_immune_system1.69063084
35MP0002653_abnormal_ependyma_morphology1.66026136
36MP0003172_abnormal_lysosome_physiology1.65586346
37MP0000703_abnormal_thymus_morphology1.63091351
38MP0000689_abnormal_spleen_morphology1.61182535
39MP0003252_abnormal_bile_duct1.54333704
40MP0002148_abnormal_hypersensitivity_rea1.53762811
41MP0006035_abnormal_mitochondrial_morpho1.51359810
42MP0001845_abnormal_inflammatory_respons1.50759812
43MP0003866_abnormal_defecation1.49251015
44MP0005075_abnormal_melanosome_morpholog1.49031782
45MP0003136_yellow_coat_color1.43715671
46MP0001533_abnormal_skeleton_physiology1.43113493
47MP0005397_hematopoietic_system_phenotyp1.41075508
48MP0001545_abnormal_hematopoietic_system1.41075508
49MP0000465_gastrointestinal_hemorrhage1.39533166
50MP0002429_abnormal_blood_cell1.37541363
51MP0010155_abnormal_intestine_physiology1.30607949
52MP0003300_gastrointestinal_ulcer1.28773220
53MP0005174_abnormal_tail_pigmentation1.28274971
54MP0005084_abnormal_gallbladder_morpholo1.24800260
55MP0005464_abnormal_platelet_physiology1.24702852
56MP0005310_abnormal_salivary_gland1.14988829
57MP0008469_abnormal_protein_level1.13327762
58MP0004883_abnormal_blood_vessel1.12704602
59MP0003828_pulmonary_edema1.12317520
60MP0008004_abnormal_stomach_pH1.10696512
61MP0003183_abnormal_peptide_metabolism1.09196254
62MP0006082_CNS_inflammation1.07936557
63MP0008872_abnormal_physiological_respon1.04327325
64MP0009765_abnormal_xenobiotic_induced1.03208735
65MP0001968_abnormal_touch/_nociception1.03036089
66MP0003698_abnormal_male_reproductive0.98298384
67MP0004808_abnormal_hematopoietic_stem0.97141174
68MP0001929_abnormal_gametogenesis0.96819602
69MP0008260_abnormal_autophagy0.95290077
70MP0002102_abnormal_ear_morphology0.91665815
71MP0002693_abnormal_pancreas_physiology0.90853342
72MP0003787_abnormal_imprinting0.89747769
73MP0002928_abnormal_bile_duct0.87770173
74MP0003806_abnormal_nucleotide_metabolis0.86791186
75MP0001853_heart_inflammation0.85628660
76MP0004947_skin_inflammation0.84753968
77MP0005451_abnormal_body_composition0.84007784
78MP0006036_abnormal_mitochondrial_physio0.83224808
79MP0002736_abnormal_nociception_after0.82208054
80MP0008058_abnormal_DNA_repair0.81761388
81MP0003191_abnormal_cellular_cholesterol0.77934284
82MP0005248_abnormal_Harderian_gland0.75456446
83MP0004484_altered_response_of0.74956880
84MP0001501_abnormal_sleep_pattern0.74754571
85MP0001764_abnormal_homeostasis0.74642135
86MP0005164_abnormal_response_to0.73680321
87MP0002138_abnormal_hepatobiliary_system0.73116247
88MP0005376_homeostasis/metabolism_phenot0.67093409
89MP0001663_abnormal_digestive_system0.66212262
90MP0005166_decreased_susceptibility_to0.63714189
91MP0005319_abnormal_enzyme/_coenzyme0.62635047
92MP0001486_abnormal_startle_reflex0.59411608
93MP0004742_abnormal_vestibular_system0.56268752
94MP0009333_abnormal_splenocyte_physiolog0.56240872
95MP0008995_early_reproductive_senescence0.55776730
96MP0005551_abnormal_eye_electrophysiolog0.55607494
97MP0000015_abnormal_ear_pigmentation0.55542458
98MP0002019_abnormal_tumor_incidence0.55482511
99MP0001145_abnormal_male_reproductive0.54048399
100MP0009763_increased_sensitivity_to0.53304903

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.09994561
2Hypochromic microcytic anemia (HP:0004840)4.93610749
3Abnormal delayed hypersensitivity skin test (HP:0002963)4.78114508
4Retrobulbar optic neuritis (HP:0100654)4.68974107
5Optic neuritis (HP:0100653)4.68974107
6Recurrent bacterial skin infections (HP:0005406)4.67566657
7Recurrent abscess formation (HP:0002722)4.65724385
8Orchitis (HP:0100796)4.61024534
9Stomatitis (HP:0010280)4.30405281
10Elevated erythrocyte sedimentation rate (HP:0003565)4.29960637
11Hypochromic anemia (HP:0001931)4.26111087
12Severe visual impairment (HP:0001141)4.23240294
13Eczematoid dermatitis (HP:0000976)4.07414749
14Encephalitis (HP:0002383)3.73272436
15Stomach cancer (HP:0012126)3.67683907
16Chronic obstructive pulmonary disease (HP:0006510)3.54708384
17Obstructive lung disease (HP:0006536)3.54708384
18Recurrent fungal infections (HP:0002841)3.40765948
19Panhypogammaglobulinemia (HP:0003139)3.39459221
20Granulocytopenia (HP:0001913)3.30915668
21Meningitis (HP:0001287)3.29382851
22Abnormality of macrophages (HP:0004311)3.24871521
23Recurrent gram-negative bacterial infections (HP:0005420)3.24556224
24Keratoconjunctivitis sicca (HP:0001097)3.16949092
25Leukocytosis (HP:0001974)3.16772763
26Vasculitis (HP:0002633)3.14252670
27Eosinophilia (HP:0001880)3.13806159
28Gastrointestinal infarctions (HP:0005244)3.13181916
29Absent/shortened dynein arms (HP:0200106)3.13159686
30Dynein arm defect of respiratory motile cilia (HP:0012255)3.13159686
31Recurrent skin infections (HP:0001581)3.04837392
32Keratoconjunctivitis (HP:0001096)2.92646836
33Abnormality of T cell physiology (HP:0011840)2.88423757
34Recurrent cutaneous fungal infections (HP:0011370)2.84790092
35Chronic mucocutaneous candidiasis (HP:0002728)2.84790092
36Mediastinal lymphadenopathy (HP:0100721)2.84742705
37Chest pain (HP:0100749)2.76073500
38Abnormality of T cell number (HP:0011839)2.69560138
39Abnormality of B cell number (HP:0010975)2.69497614
40Autoimmune hemolytic anemia (HP:0001890)2.67099158
41Progressive cerebellar ataxia (HP:0002073)2.67004742
42Genetic anticipation (HP:0003743)2.66685696
43Abnormality of T cells (HP:0002843)2.63120361
44Hemoptysis (HP:0002105)2.62644254
45Spontaneous hematomas (HP:0007420)2.62160537
46Abnormality of eosinophils (HP:0001879)2.60171058
47Microcytic anemia (HP:0001935)2.56657204
48Autoimmune thrombocytopenia (HP:0001973)2.56649283
49Congenital stationary night blindness (HP:0007642)2.52077421
50Prolonged bleeding time (HP:0003010)2.50023388
51Increased IgM level (HP:0003496)2.41043350
52Urticaria (HP:0001025)2.37958612
53Recurrent sinusitis (HP:0011108)2.36839892
54Abnormal rod and cone electroretinograms (HP:0008323)2.33621998
55Inflammation of the large intestine (HP:0002037)2.32099186
56Abnormality of the prostate (HP:0008775)2.31516584
57Attenuation of retinal blood vessels (HP:0007843)2.28466597
58Slow saccadic eye movements (HP:0000514)2.27109772
59Increased IgE level (HP:0003212)2.26512199
60Gingivitis (HP:0000230)2.24762209
61Abnormal ciliary motility (HP:0012262)2.24313851
62Arterial thrombosis (HP:0004420)2.23754065
63Episodic fever (HP:0001954)2.20356271
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.18545748
65Pulmonary embolism (HP:0002204)2.17290788
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.16511654
67Gastrointestinal inflammation (HP:0004386)2.13036942
68Anorexia (HP:0002039)2.12761112
69Pustule (HP:0200039)2.09327859
70Lymphopenia (HP:0001888)2.08947304
71Postural instability (HP:0002172)2.08542350
72Abnormal respiratory motile cilium morphology (HP:0005938)2.06034197
73Abnormal respiratory epithelium morphology (HP:0012253)2.06034197
74Prostate neoplasm (HP:0100787)2.05866354
75Peritonitis (HP:0002586)2.03765192
76Pancreatic cysts (HP:0001737)2.00986840
77T lymphocytopenia (HP:0005403)1.99202252
78Abnormality of the pleura (HP:0002103)1.97199573
79Pulmonary infiltrates (HP:0002113)1.95878813
80True hermaphroditism (HP:0010459)1.95651080
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93969227
82Abnormal respiratory motile cilium physiology (HP:0012261)1.93882004
83Abnormality of DNA repair (HP:0003254)1.91886239
84Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89434704
85Abnormality of the columella (HP:0009929)1.89306641
86Gangrene (HP:0100758)1.88106480
87Gingival bleeding (HP:0000225)1.87032331
88Abnormality of male internal genitalia (HP:0000022)1.86982755
89Abnormality of the heme biosynthetic pathway (HP:0010472)1.81265343
90Sepsis (HP:0100806)1.80704835
91Pendular nystagmus (HP:0012043)1.79498376
92Recurrent viral infections (HP:0004429)1.77358435
93Epistaxis (HP:0000421)1.77255228
94IgM deficiency (HP:0002850)1.75946574
95Gaze-evoked nystagmus (HP:0000640)1.75748993
96Cellulitis (HP:0100658)1.74427609
97Petechiae (HP:0000967)1.73905575
98Tetany (HP:0001281)1.71582491
99Severe combined immunodeficiency (HP:0004430)1.71193228
100Papilledema (HP:0001085)1.68276193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.12507605
2RIPK43.86151316
3PINK13.54845740
4IRAK43.31241798
5TNK23.01589469
6MAP4K12.81355794
7TAOK32.70521622
8MAP2K32.65335908
9TXK2.46189611
10INSRR2.35612354
11GRK62.24832768
12BLK2.16887003
13BTK1.94058411
14CSK1.91582119
15TNIK1.81666672
16NLK1.79047941
17FES1.77460104
18MARK31.67327803
19FRK1.63369818
20MAP4K21.58091009
21HCK1.57490037
22MAP3K71.48408448
23TYK21.44897307
24EPHB11.44799644
25OXSR11.40265070
26SYK1.36152069
27ITK1.35878413
28JAK21.33256619
29ZAP701.30625249
30MAP3K31.25559490
31TEC1.22525244
32ERN11.21889274
33TAOK11.21427161
34MAP3K11.20201559
35SIK31.19669592
36JAK31.17865754
37LYN1.17351112
38PASK1.15017411
39KSR21.11027360
40STK381.09521393
41FGR1.05760869
42YES11.05738229
43PIK3CG1.02061843
44NUAK10.99852828
45PDK10.94790109
46MAP2K60.94333320
47BMPR1B0.90512317
48PRKD20.88940084
49MAP3K110.88887008
50PRKCQ0.88099573
51KIT0.87035037
52LCK0.86933284
53DAPK20.84705214
54PDPK10.84060706
55DYRK30.83920511
56MARK20.83883775
57SIK20.82589266
58PTK2B0.80797369
59IRAK10.80197490
60IKBKE0.79798911
61NME10.77593092
62STK110.75827361
63MATK0.70738296
64ADRBK20.65075664
65CSF1R0.64171190
66PLK40.63637987
67IRAK20.58885549
68GRK10.57941437
69CAMKK10.54145603
70WNK30.53778928
71RAF10.53116687
72WNK10.52959334
73STK100.51459945
74ALK0.48446120
75KSR10.45810058
76MAPK130.45700954
77CAMKK20.45262172
78PAK30.45098363
79CAMK10.43830164
80FYN0.43630105
81STK38L0.43561595
82BRD40.43306491
83DYRK1B0.40914059
84PRKG20.40804414
85ACVR1B0.40451742
86PKN20.40053006
87PTK60.36973876
88MAP3K20.36518079
89TGFBR20.35462815
90PRKCZ0.34788851
91PRKAA20.34295005
92IKBKB0.33860811
93MAP2K40.33602834
94RET0.33532751
95MAP3K50.33190019
96DYRK20.32842799
97MAP2K20.31688848
98FLT30.30723636
99CAMK40.28735133
100MAPK120.25815350

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.67435067
2Primary immunodeficiency_Homo sapiens_hsa053402.64174449
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.57127379
4Leishmaniasis_Homo sapiens_hsa051402.49510652
5Staphylococcus aureus infection_Homo sapiens_hsa051502.23468294
6Regulation of autophagy_Homo sapiens_hsa041402.23409804
7Graft-versus-host disease_Homo sapiens_hsa053322.13200367
8B cell receptor signaling pathway_Homo sapiens_hsa046622.03604374
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.98443127
10Autoimmune thyroid disease_Homo sapiens_hsa053201.94387296
11Allograft rejection_Homo sapiens_hsa053301.93808048
12Tuberculosis_Homo sapiens_hsa051521.92744948
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.84204177
14Type I diabetes mellitus_Homo sapiens_hsa049401.82531702
15Olfactory transduction_Homo sapiens_hsa047401.79954497
16T cell receptor signaling pathway_Homo sapiens_hsa046601.76646566
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73841464
18Acute myeloid leukemia_Homo sapiens_hsa052211.71948196
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71149440
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.67838471
21Hematopoietic cell lineage_Homo sapiens_hsa046401.67319166
22Malaria_Homo sapiens_hsa051441.60672681
23Measles_Homo sapiens_hsa051621.60048736
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51870661
25Chemokine signaling pathway_Homo sapiens_hsa040621.46849871
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46479240
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37931084
28African trypanosomiasis_Homo sapiens_hsa051431.36969796
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.36420946
30Herpes simplex infection_Homo sapiens_hsa051681.32654870
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32515758
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29286689
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.28149289
34Influenza A_Homo sapiens_hsa051641.26408483
35Platelet activation_Homo sapiens_hsa046111.23949089
36Phototransduction_Homo sapiens_hsa047441.20554049
37Dorso-ventral axis formation_Homo sapiens_hsa043201.20211932
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18112520
39Antigen processing and presentation_Homo sapiens_hsa046121.16718076
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11930960
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05419854
42Phagosome_Homo sapiens_hsa041451.04027081
43TNF signaling pathway_Homo sapiens_hsa046680.97132793
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95161743
45FoxO signaling pathway_Homo sapiens_hsa040680.92952541
46Legionellosis_Homo sapiens_hsa051340.90959787
47Type II diabetes mellitus_Homo sapiens_hsa049300.88834589
48Butanoate metabolism_Homo sapiens_hsa006500.85854661
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85105593
50Hepatitis B_Homo sapiens_hsa051610.83121211
51Non-small cell lung cancer_Homo sapiens_hsa052230.82568622
52Choline metabolism in cancer_Homo sapiens_hsa052310.81762976
53Viral myocarditis_Homo sapiens_hsa054160.81531550
54Linoleic acid metabolism_Homo sapiens_hsa005910.80723580
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79353476
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.79204633
57Ether lipid metabolism_Homo sapiens_hsa005650.77334433
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76751544
59Base excision repair_Homo sapiens_hsa034100.75161564
60Apoptosis_Homo sapiens_hsa042100.75101903
61Hepatitis C_Homo sapiens_hsa051600.74452404
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72786086
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67730759
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67061610
65Prolactin signaling pathway_Homo sapiens_hsa049170.66751153
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.66008180
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65326049
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64932662
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64669889
70Toxoplasmosis_Homo sapiens_hsa051450.63036471
71ABC transporters_Homo sapiens_hsa020100.62462543
72VEGF signaling pathway_Homo sapiens_hsa043700.61351070
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56911707
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56254726
75Arachidonic acid metabolism_Homo sapiens_hsa005900.56124932
76Notch signaling pathway_Homo sapiens_hsa043300.54405905
77Taste transduction_Homo sapiens_hsa047420.51969125
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.50701637
79Endometrial cancer_Homo sapiens_hsa052130.49968363
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.49135446
81Chemical carcinogenesis_Homo sapiens_hsa052040.48634040
82Glycerolipid metabolism_Homo sapiens_hsa005610.48198115
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47851794
84Homologous recombination_Homo sapiens_hsa034400.47261902
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47122096
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.46539765
87Fanconi anemia pathway_Homo sapiens_hsa034600.45514708
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45456651
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.42958836
90Colorectal cancer_Homo sapiens_hsa052100.42734397
91cAMP signaling pathway_Homo sapiens_hsa040240.41849295
92MAPK signaling pathway_Homo sapiens_hsa040100.41611940
93Viral carcinogenesis_Homo sapiens_hsa052030.40686654
94Endocytosis_Homo sapiens_hsa041440.40251936
95Rap1 signaling pathway_Homo sapiens_hsa040150.39875295
96Nitrogen metabolism_Homo sapiens_hsa009100.39169209
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37767187
98Asthma_Homo sapiens_hsa053100.37522207
99Insulin resistance_Homo sapiens_hsa049310.35799085
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35794644

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