AGBL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.33606424
2epithelial cilium movement (GO:0003351)5.44109528
3cilium movement (GO:0003341)5.36232002
4acrosome reaction (GO:0007340)5.13435906
5sperm motility (GO:0030317)4.95927544
6axonemal dynein complex assembly (GO:0070286)4.93125021
7protein localization to cilium (GO:0061512)4.80158280
8cell wall macromolecule metabolic process (GO:0044036)4.73245915
9cell wall macromolecule catabolic process (GO:0016998)4.73245915
10behavioral response to nicotine (GO:0035095)4.71759254
11glutamate secretion (GO:0014047)4.68301672
12calcium ion-dependent exocytosis (GO:0017156)4.55439308
13neuron cell-cell adhesion (GO:0007158)4.50451261
14motile cilium assembly (GO:0044458)4.49959424
15vocalization behavior (GO:0071625)4.47006554
16fusion of sperm to egg plasma membrane (GO:0007342)4.46283303
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.45546299
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.43327011
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.42494692
20synaptic vesicle exocytosis (GO:0016079)4.36272674
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.34094898
22acrosome assembly (GO:0001675)4.28676930
23regulation of short-term neuronal synaptic plasticity (GO:0048172)4.27309690
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.25728070
25regulation of cilium movement (GO:0003352)4.23149473
26presynaptic membrane organization (GO:0097090)4.18753814
27regulation of glutamate receptor signaling pathway (GO:1900449)4.17744874
28protein localization to synapse (GO:0035418)4.13108554
29multicellular organism reproduction (GO:0032504)4.13029981
30synaptic vesicle docking involved in exocytosis (GO:0016081)4.04821483
31presynaptic membrane assembly (GO:0097105)4.03414173
32regulation of synaptic vesicle exocytosis (GO:2000300)4.00234100
33plasma membrane fusion (GO:0045026)3.95260148
34detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.93622861
35glutamate receptor signaling pathway (GO:0007215)3.87050699
36sperm-egg recognition (GO:0035036)3.80146343
37detection of light stimulus involved in sensory perception (GO:0050962)3.79912969
38detection of light stimulus involved in visual perception (GO:0050908)3.79912969
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.79302492
40ionotropic glutamate receptor signaling pathway (GO:0035235)3.79040348
41fucose catabolic process (GO:0019317)3.74840270
42L-fucose metabolic process (GO:0042354)3.74840270
43L-fucose catabolic process (GO:0042355)3.74840270
44indolalkylamine metabolic process (GO:0006586)3.68992474
45membrane depolarization during action potential (GO:0086010)3.68664714
46gamma-aminobutyric acid transport (GO:0015812)3.68226826
47indole-containing compound catabolic process (GO:0042436)3.67613952
48indolalkylamine catabolic process (GO:0046218)3.67613952
49tryptophan catabolic process (GO:0006569)3.67613952
50neuron-neuron synaptic transmission (GO:0007270)3.66109938
51spermatid development (GO:0007286)3.65755190
52cellular ketone body metabolic process (GO:0046950)3.62040895
53synaptic transmission, glutamatergic (GO:0035249)3.61373425
54protein K11-linked deubiquitination (GO:0035871)3.61104096
55ventricular system development (GO:0021591)3.55045251
56neuronal action potential propagation (GO:0019227)3.50241891
57piRNA metabolic process (GO:0034587)3.50096570
58regulation of synaptic vesicle transport (GO:1902803)3.49476794
59nonmotile primary cilium assembly (GO:0035058)3.48058626
60neurotransmitter-gated ion channel clustering (GO:0072578)3.45191325
61startle response (GO:0001964)3.40173764
62retinal cone cell development (GO:0046549)3.37369261
63negative regulation of inclusion body assembly (GO:0090084)3.37090185
64postsynaptic membrane organization (GO:0001941)3.36864938
65cell-cell recognition (GO:0009988)3.36805372
66axoneme assembly (GO:0035082)3.34894187
67reflex (GO:0060004)3.34259907
68gamma-aminobutyric acid signaling pathway (GO:0007214)3.32857524
69male meiosis (GO:0007140)3.32481657
70kynurenine metabolic process (GO:0070189)3.29221314
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28290555
72neurotransmitter secretion (GO:0007269)3.27089155
73cerebellar Purkinje cell differentiation (GO:0021702)3.26488865
74indole-containing compound metabolic process (GO:0042430)3.26394019
75reproduction (GO:0000003)3.26194832
76righting reflex (GO:0060013)3.25495761
77sperm capacitation (GO:0048240)3.24249981
78locomotory exploration behavior (GO:0035641)3.23803177
79detection of calcium ion (GO:0005513)3.23339015
80positive regulation of neurotransmitter secretion (GO:0001956)3.23099747
81regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22609135
82ketone body metabolic process (GO:1902224)3.20905424
83neuron recognition (GO:0008038)3.17463850
84binding of sperm to zona pellucida (GO:0007339)3.16907657
85intraciliary transport (GO:0042073)3.15277561
86regulation of postsynaptic membrane potential (GO:0060078)3.13658951
87behavioral response to cocaine (GO:0048148)3.13556424
88neuronal action potential (GO:0019228)3.13461587
89regulation of synaptic transmission, glutamatergic (GO:0051966)3.12860027
90transmission of nerve impulse (GO:0019226)3.12808896
91tryptophan metabolic process (GO:0006568)3.10563712
92ATP hydrolysis coupled proton transport (GO:0015991)3.10385553
93energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.10385553
94negative regulation of synaptic transmission, GABAergic (GO:0032229)3.10341304
95membrane depolarization (GO:0051899)3.09876610
96regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.09636430
97long-term synaptic potentiation (GO:0060291)3.08451747
98regulation of neuronal synaptic plasticity (GO:0048168)3.07682890
99response to histamine (GO:0034776)3.06670589
100synaptic vesicle maturation (GO:0016188)3.05819390
101serotonin metabolic process (GO:0042428)3.04672582
102positive regulation of neurotransmitter transport (GO:0051590)3.04587029
103regulation of neurotransmitter secretion (GO:0046928)3.02256615
104calcium ion import (GO:0070509)3.02077645
105regulation of vesicle fusion (GO:0031338)2.98744618
106synaptic vesicle endocytosis (GO:0048488)2.98640803
107neurotransmitter transport (GO:0006836)2.98446208
108axonal fasciculation (GO:0007413)2.98376747
109pyrimidine nucleobase catabolic process (GO:0006208)2.96696585
110positive regulation of membrane potential (GO:0045838)2.95214131
111regulation of glutamate secretion (GO:0014048)2.94435763
112behavioral response to ethanol (GO:0048149)2.93367580
113single fertilization (GO:0007338)2.92352601
114water-soluble vitamin biosynthetic process (GO:0042364)2.92210997
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91328463
116neural tube formation (GO:0001841)2.90861008
117cilium morphogenesis (GO:0060271)2.90469904
118primary amino compound metabolic process (GO:1901160)2.89264817
119urinary tract smooth muscle contraction (GO:0014848)2.89028140
120regulation of long-term neuronal synaptic plasticity (GO:0048169)2.88851640
121protein polyglutamylation (GO:0018095)2.86940274
122exploration behavior (GO:0035640)2.86783685
123positive regulation of synapse assembly (GO:0051965)2.85051823
124microtubule severing (GO:0051013)2.84610149
125positive regulation of oligodendrocyte differentiation (GO:0048714)2.84021588
126serotonin receptor signaling pathway (GO:0007210)2.83312771
127regulation of protein kinase A signaling (GO:0010738)2.82104375
128photoreceptor cell maintenance (GO:0045494)2.81767155
129regulation of action potential (GO:0098900)2.81461560
130cilium organization (GO:0044782)2.80293364
131inner ear receptor stereocilium organization (GO:0060122)2.80091499
132negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79881442
133transferrin transport (GO:0033572)2.79798757
134protein-cofactor linkage (GO:0018065)2.78247282
135positive regulation of synaptic transmission, GABAergic (GO:0032230)2.78006617
136response to pheromone (GO:0019236)2.77060874
137adaptation of signaling pathway (GO:0023058)2.76985231
138lactate metabolic process (GO:0006089)2.76075026
139dendritic spine morphogenesis (GO:0060997)2.75338010
140auditory receptor cell stereocilium organization (GO:0060088)2.75205367
141cilium assembly (GO:0042384)2.75198558
142glycerophospholipid catabolic process (GO:0046475)2.74509793
143nucleobase catabolic process (GO:0046113)2.73357751
144cornea development in camera-type eye (GO:0061303)2.67993821
145detection of mechanical stimulus involved in sensory perception (GO:0050974)2.67521572
146proline transport (GO:0015824)2.65638838
147cellular biogenic amine catabolic process (GO:0042402)2.65318850
148amine catabolic process (GO:0009310)2.65318850
149auditory behavior (GO:0031223)2.62539039
150C4-dicarboxylate transport (GO:0015740)2.62138249
151glycosphingolipid biosynthetic process (GO:0006688)2.59714502
152platelet dense granule organization (GO:0060155)2.59487756
153negative regulation of telomere maintenance (GO:0032205)2.58174817
154respiratory chain complex IV assembly (GO:0008535)2.54428754
155sulfation (GO:0051923)2.53837594
156signal peptide processing (GO:0006465)2.53523621
157cAMP catabolic process (GO:0006198)2.51550647
158retinal ganglion cell axon guidance (GO:0031290)2.50954202
159hindbrain development (GO:0030902)2.50707999
160replication fork processing (GO:0031297)2.47436066
161photoreceptor cell development (GO:0042461)2.45709445
162spinal cord motor neuron differentiation (GO:0021522)2.44178585
163regulation of neurotransmitter uptake (GO:0051580)2.41129304
164thyroid hormone metabolic process (GO:0042403)2.40392605
165protein complex biogenesis (GO:0070271)2.39918538
166cellular potassium ion transport (GO:0071804)2.39691222
167potassium ion transmembrane transport (GO:0071805)2.39691222
168action potential (GO:0001508)2.37330151
169preassembly of GPI anchor in ER membrane (GO:0016254)2.35846469
170negative regulation of mast cell activation (GO:0033004)2.35508394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.46349956
2GBX2_23144817_ChIP-Seq_PC3_Human3.79959366
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.85099384
4TAF15_26573619_Chip-Seq_HEK293_Human2.63012729
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50061141
6REST_21632747_ChIP-Seq_MESCs_Mouse2.39720629
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38766400
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33687860
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18291356
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14757176
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13521446
12* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12389978
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03362402
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.97939163
15EWS_26573619_Chip-Seq_HEK293_Human1.95224451
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.94932585
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94826129
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.94210187
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94093430
20VDR_22108803_ChIP-Seq_LS180_Human1.91976405
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89096690
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88502080
23* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88360893
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87903035
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87286908
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.84464173
27* SMAD4_21799915_ChIP-Seq_A2780_Human1.83963271
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81379511
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80411826
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79968713
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79516287
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78047483
33P300_19829295_ChIP-Seq_ESCs_Human1.77288130
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72515722
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72515722
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72356610
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.70668283
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70647629
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.70350385
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.68323855
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68203943
42RNF2_27304074_Chip-Seq_NSC_Mouse1.63891184
43* DROSHA_22980978_ChIP-Seq_HELA_Human1.63745571
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.60480426
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59489816
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56991849
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.55849192
48ZNF274_21170338_ChIP-Seq_K562_Hela1.55118523
49BCAT_22108803_ChIP-Seq_LS180_Human1.54617655
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54531023
51TP53_22573176_ChIP-Seq_HFKS_Human1.50865742
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49079633
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46633090
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46289608
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.46283355
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.46061834
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.45550496
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44811991
59FUS_26573619_Chip-Seq_HEK293_Human1.43916098
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43454925
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41363083
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41267228
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40756772
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40560986
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39100856
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38225254
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34079577
68* STAT3_23295773_ChIP-Seq_U87_Human1.32328472
69P53_22387025_ChIP-Seq_ESCs_Mouse1.31304654
70* TCF4_23295773_ChIP-Seq_U87_Human1.30129855
71ER_23166858_ChIP-Seq_MCF-7_Human1.29498869
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28059192
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27704074
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27704074
75* KDM2B_26808549_Chip-Seq_REH_Human1.27477956
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26191479
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.25841138
78AR_25329375_ChIP-Seq_VCAP_Human1.25586077
79TCF4_22108803_ChIP-Seq_LS180_Human1.25534065
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.25041974
81NANOG_19829295_ChIP-Seq_ESCs_Human1.24898931
82SOX2_19829295_ChIP-Seq_ESCs_Human1.24898931
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24445307
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.24110729
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.21730690
86* SMAD4_21741376_ChIP-Seq_EPCs_Human1.20902103
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20407112
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19805538
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19769055
90AR_21572438_ChIP-Seq_LNCaP_Human1.17411997
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17336546
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.17310721
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17172800
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.16512341
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16512341
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16094796
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16034941
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15908016
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.15531953
100IRF1_19129219_ChIP-ChIP_H3396_Human1.15304874
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.13982392
102CBP_20019798_ChIP-Seq_JUKART_Human1.13702988
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13702988
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13530087
105P300_18555785_Chip-Seq_ESCs_Mouse1.12759247
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.12712391
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.12489338
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12379880
109FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12173590
110* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11659310
111* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11526705
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11448428
113RUNX2_22187159_ChIP-Seq_PCA_Human1.11019978
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09718446
115PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07950138
116MYC_18940864_ChIP-ChIP_HL60_Human1.07873109
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.07855732
118RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07827762
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06561460
120* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06420633
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05264272
122NCOR_22424771_ChIP-Seq_293T_Human1.05187195
123ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04363099
124IGF1R_20145208_ChIP-Seq_DFB_Human1.04022210
125NMYC_18555785_Chip-Seq_ESCs_Mouse1.03701727
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03160179
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02251950
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02098544
129NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01824748
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.01434223
131GATA3_21878914_ChIP-Seq_MCF-7_Human1.00858015
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97934638

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.86770213
2MP0004859_abnormal_synaptic_plasticity4.45152072
3MP0005410_abnormal_fertilization4.20472848
4MP0003635_abnormal_synaptic_transmissio3.43003956
5MP0009046_muscle_twitch3.24116484
6MP0009745_abnormal_behavioral_response3.16415029
7MP0004270_analgesia3.04405065
8MP0001968_abnormal_touch/_nociception2.95061765
9MP0005423_abnormal_somatic_nervous2.84068203
10MP0002064_seizures2.80486323
11MP0002063_abnormal_learning/memory/cond2.76754886
12MP0002572_abnormal_emotion/affect_behav2.72122893
13MP0001984_abnormal_olfaction2.59216013
14MP0003195_calcinosis2.57444221
15MP0002736_abnormal_nociception_after2.57080919
16MP0005645_abnormal_hypothalamus_physiol2.55166936
17MP0002272_abnormal_nervous_system2.43655224
18MP0005646_abnormal_pituitary_gland2.37530051
19MP0006276_abnormal_autonomic_nervous2.35571350
20MP0002734_abnormal_mechanical_nocicepti2.33538131
21MP0001486_abnormal_startle_reflex2.32465686
22MP0001501_abnormal_sleep_pattern2.26786858
23MP0002735_abnormal_chemical_nociception2.25033604
24MP0008877_abnormal_DNA_methylation2.17445558
25MP0003122_maternal_imprinting2.10144454
26MP0001905_abnormal_dopamine_level2.06283307
27MP0001529_abnormal_vocalization2.02858293
28MP0003787_abnormal_imprinting1.99244558
29MP0004885_abnormal_endolymph1.95895897
30MP0001440_abnormal_grooming_behavior1.93381105
31MP0002067_abnormal_sensory_capabilities1.92944911
32MP0002733_abnormal_thermal_nociception1.87777944
33MP0004147_increased_porphyrin_level1.85397139
34MP0003698_abnormal_male_reproductive1.85382419
35MP0003136_yellow_coat_color1.84450831
36MP0008875_abnormal_xenobiotic_pharmacok1.79954983
37MP0003283_abnormal_digestive_organ1.78287351
38MP0001970_abnormal_pain_threshold1.75862158
39MP0002557_abnormal_social/conspecific_i1.71427098
40MP0002822_catalepsy1.70020289
41MP0003879_abnormal_hair_cell1.69505518
42MP0002876_abnormal_thyroid_physiology1.61702575
43MP0005386_behavior/neurological_phenoty1.54777087
44MP0004924_abnormal_behavior1.54777087
45MP0002938_white_spotting1.54481468
46MP0000778_abnormal_nervous_system1.54269528
47MP0001485_abnormal_pinna_reflex1.54200786
48MP0002184_abnormal_innervation1.53634264
49MP0001502_abnormal_circadian_rhythm1.49865627
50MP0006292_abnormal_olfactory_placode1.48835009
51MP0004133_heterotaxia1.45535153
52MP0001188_hyperpigmentation1.44422897
53MP0002837_dystrophic_cardiac_calcinosis1.40196343
54MP0000427_abnormal_hair_cycle1.38107513
55MP0009780_abnormal_chondrocyte_physiolo1.37070877
56MP0004142_abnormal_muscle_tone1.36815146
57MP0002234_abnormal_pharynx_morphology1.36266015
58MP0010386_abnormal_urinary_bladder1.36163286
59MP0001929_abnormal_gametogenesis1.35633661
60MP0002928_abnormal_bile_duct1.35038257
61MP0008569_lethality_at_weaning1.32511373
62MP0002653_abnormal_ependyma_morphology1.32228672
63MP0005551_abnormal_eye_electrophysiolog1.27559243
64MP0004811_abnormal_neuron_physiology1.25741384
65MP0002138_abnormal_hepatobiliary_system1.23316702
66MP0002066_abnormal_motor_capabilities/c1.20928931
67MP0002882_abnormal_neuron_morphology1.18700784
68MP0003183_abnormal_peptide_metabolism1.18448013
69MP0001986_abnormal_taste_sensitivity1.18362732
70MP0004742_abnormal_vestibular_system1.17601901
71MP0002909_abnormal_adrenal_gland1.17523665
72MP0005377_hearing/vestibular/ear_phenot1.16175836
73MP0003878_abnormal_ear_physiology1.16175836
74MP0000955_abnormal_spinal_cord1.11806703
75MP0000013_abnormal_adipose_tissue1.10535066
76MP0005389_reproductive_system_phenotype1.10170111
77MP0005084_abnormal_gallbladder_morpholo1.07011946
78MP0000372_irregular_coat_pigmentation1.06995283
79MP0003011_delayed_dark_adaptation1.06940091
80MP0003633_abnormal_nervous_system1.06092517
81MP0000631_abnormal_neuroendocrine_gland1.04682218
82MP0005379_endocrine/exocrine_gland_phen0.98824001
83MP0002277_abnormal_respiratory_mucosa0.98207944
84MP0005171_absent_coat_pigmentation0.96851796
85MP0005195_abnormal_posterior_eye0.96647761
86MP0005535_abnormal_body_temperature0.95677105
87MP0005174_abnormal_tail_pigmentation0.95444451
88MP0008872_abnormal_physiological_respon0.95353137
89MP0001963_abnormal_hearing_physiology0.93155557
90MP0001919_abnormal_reproductive_system0.92537687
91MP0000383_abnormal_hair_follicle0.92249109
92MP0002751_abnormal_autonomic_nervous0.92047392
93MP0002161_abnormal_fertility/fecundity0.91909650
94MP0005623_abnormal_meninges_morphology0.91164142
95MP0002152_abnormal_brain_morphology0.89194020
96MP0001765_abnormal_ion_homeostasis0.88417218
97MP0003631_nervous_system_phenotype0.86233148
98MP0003329_amyloid_beta_deposits0.85961767
99MP0003718_maternal_effect0.85673228
100MP0002069_abnormal_eating/drinking_beha0.84392426
101MP0002229_neurodegeneration0.84131149
102MP0005499_abnormal_olfactory_system0.83599853
103MP0005394_taste/olfaction_phenotype0.83599853
104MP0001664_abnormal_digestion0.83220616
105MP0004215_abnormal_myocardial_fiber0.82886833
106MP0008995_early_reproductive_senescence0.81437725
107MP0004145_abnormal_muscle_electrophysio0.81387911
108MP0000647_abnormal_sebaceous_gland0.81333841
109MP0003137_abnormal_impulse_conducting0.78461020
110MP0002752_abnormal_somatic_nervous0.77888496
111MP0003890_abnormal_embryonic-extraembry0.76681302
112MP0002163_abnormal_gland_morphology0.76165388
113MP0003121_genomic_imprinting0.76078972
114MP0008789_abnormal_olfactory_epithelium0.75823552
115MP0002210_abnormal_sex_determination0.75682264
116MP0002095_abnormal_skin_pigmentation0.75646767
117MP0005409_darkened_coat_color0.74763070
118MP0004043_abnormal_pH_regulation0.74284852
119MP0000026_abnormal_inner_ear0.73952082
120MP0000751_myopathy0.73151344
121MP0002638_abnormal_pupillary_reflex0.72930907
122MP0003646_muscle_fatigue0.70899669
123MP0004085_abnormal_heartbeat0.69648558
124MP0006072_abnormal_retinal_apoptosis0.69526206
125MP0005253_abnormal_eye_physiology0.67677740
126MP0002160_abnormal_reproductive_system0.67574069
127MP0002102_abnormal_ear_morphology0.66391277
128MP0000569_abnormal_digit_pigmentation0.64800588
129MP0008874_decreased_physiological_sensi0.64190977
130MP0001145_abnormal_male_reproductive0.59200390
131MP0008004_abnormal_stomach_pH0.56777894
132MP0002693_abnormal_pancreas_physiology0.56444389
133MP0004484_altered_response_of0.55879220

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.67902684
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.38328287
3Absent/shortened dynein arms (HP:0200106)7.38328287
4Abnormal respiratory motile cilium physiology (HP:0012261)6.47513666
5Abnormal ciliary motility (HP:0012262)6.31261421
6Focal motor seizures (HP:0011153)6.24011524
7Abnormal respiratory epithelium morphology (HP:0012253)5.80739201
8Abnormal respiratory motile cilium morphology (HP:0005938)5.80739201
9Rhinitis (HP:0012384)5.32488924
10Epileptic encephalopathy (HP:0200134)4.49938403
11Pancreatic cysts (HP:0001737)4.35218992
12Focal seizures (HP:0007359)4.16996932
13Medial flaring of the eyebrow (HP:0010747)3.85662574
14Atonic seizures (HP:0010819)3.80737757
15Febrile seizures (HP:0002373)3.74731321
16Hyperventilation (HP:0002883)3.72191763
17Congenital stationary night blindness (HP:0007642)3.50834570
18Gait imbalance (HP:0002141)3.47503715
19Chronic bronchitis (HP:0004469)3.45870344
20Visual hallucinations (HP:0002367)3.40611636
21Myokymia (HP:0002411)3.40268928
22Attenuation of retinal blood vessels (HP:0007843)3.36451065
23Congenital primary aphakia (HP:0007707)3.29690925
24Nephronophthisis (HP:0000090)3.22032827
25Progressive cerebellar ataxia (HP:0002073)3.19692029
26Infertility (HP:0000789)3.16229833
27Nephrogenic diabetes insipidus (HP:0009806)3.12586206
28Abnormality of the renal cortex (HP:0011035)3.10054218
29Generalized tonic-clonic seizures (HP:0002069)2.93571089
30Absence seizures (HP:0002121)2.90112447
31Abolished electroretinogram (ERG) (HP:0000550)2.89472338
32Dialeptic seizures (HP:0011146)2.82185914
33Gaze-evoked nystagmus (HP:0000640)2.80256676
34Bony spicule pigmentary retinopathy (HP:0007737)2.79098410
35Cystic liver disease (HP:0006706)2.76938095
36Bronchiectasis (HP:0002110)2.71016632
37Abnormal rod and cone electroretinograms (HP:0008323)2.67480035
38Abnormal drinking behavior (HP:0030082)2.64944054
39Polydipsia (HP:0001959)2.64944054
40Broad-based gait (HP:0002136)2.61184040
41Congenital sensorineural hearing impairment (HP:0008527)2.61069725
42Vaginal atresia (HP:0000148)2.55088591
43Genital tract atresia (HP:0001827)2.54269304
44Pendular nystagmus (HP:0012043)2.53708593
45Molar tooth sign on MRI (HP:0002419)2.52939976
46Abnormality of midbrain morphology (HP:0002418)2.52939976
47Tubular atrophy (HP:0000092)2.51309301
48Poor coordination (HP:0002370)2.48956384
49Amblyopia (HP:0000646)2.46516142
50Sclerocornea (HP:0000647)2.46247315
51Hyperalaninemia (HP:0003348)2.41066873
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41066873
53Abnormality of alanine metabolism (HP:0010916)2.41066873
54Limb dystonia (HP:0002451)2.39912552
55Constricted visual fields (HP:0001133)2.37596972
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.35858082
57Abnormality of the renal medulla (HP:0100957)2.34972483
58Increased corneal curvature (HP:0100692)2.34091680
59Keratoconus (HP:0000563)2.34091680
60Abnormal eating behavior (HP:0100738)2.32803163
61Aplasia/Hypoplasia of the lens (HP:0008063)2.27132174
62Tubulointerstitial nephritis (HP:0001970)2.26118241
63Epileptiform EEG discharges (HP:0011182)2.25488074
64Cerebellar dysplasia (HP:0007033)2.20704459
65Impaired smooth pursuit (HP:0007772)2.20384307
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20003394
67Large for gestational age (HP:0001520)2.17154543
68Male pseudohermaphroditism (HP:0000037)2.16924815
69Decreased circulating renin level (HP:0003351)2.16009128
70Polyuria (HP:0000103)2.15290326
71Abnormality of the labia minora (HP:0012880)2.15205642
72Lissencephaly (HP:0001339)2.14583132
73Nasal polyposis (HP:0100582)2.13083339
74Abnormal hair whorl (HP:0010721)2.12424510
75Renal cortical cysts (HP:0000803)2.11852604
76Polyphagia (HP:0002591)2.11198435
77Specific learning disability (HP:0001328)2.09909483
78Inability to walk (HP:0002540)2.09543810
79Retinal dysplasia (HP:0007973)2.07838940
80Anencephaly (HP:0002323)2.07425440
81Truncal ataxia (HP:0002078)2.06586473
82Bile duct proliferation (HP:0001408)2.05395175
83Abnormal biliary tract physiology (HP:0012439)2.05395175
84Protruding tongue (HP:0010808)2.05272886
85Furrowed tongue (HP:0000221)2.03861000
86Hemiparesis (HP:0001269)2.03567239
87Abnormality of ocular smooth pursuit (HP:0000617)2.02870948
88Optic nerve hypoplasia (HP:0000609)2.02413395
89True hermaphroditism (HP:0010459)2.02219276
90Genetic anticipation (HP:0003743)2.01227155
91EEG with generalized epileptiform discharges (HP:0011198)2.00750152
92Impaired vibration sensation in the lower limbs (HP:0002166)2.00084359
93Postaxial foot polydactyly (HP:0001830)2.00004807
94Hypothermia (HP:0002045)1.98306430
95Absent speech (HP:0001344)1.97416153
96Sensory axonal neuropathy (HP:0003390)1.96804825
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95176242
98Neuroendocrine neoplasm (HP:0100634)1.94838919
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.94778463
100Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94760240
101Anxiety (HP:0000739)1.94654739
102Pheochromocytoma (HP:0002666)1.93233960
103Congenital, generalized hypertrichosis (HP:0004540)1.92164961
104Occipital encephalocele (HP:0002085)1.88285894
105Acute necrotizing encephalopathy (HP:0006965)1.86151905
106Chronic otitis media (HP:0000389)1.85551849
107Ketoacidosis (HP:0001993)1.85486996
108Hypomagnesemia (HP:0002917)1.85354832
109Hypsarrhythmia (HP:0002521)1.83201574
110Intestinal atresia (HP:0011100)1.83118024
111Abnormality of macular pigmentation (HP:0008002)1.82612773
112Chronic hepatic failure (HP:0100626)1.82297087
113Postaxial hand polydactyly (HP:0001162)1.81571342
114Pancreatic fibrosis (HP:0100732)1.80597083
115Clumsiness (HP:0002312)1.80458901
116Blue irides (HP:0000635)1.79074384
117Concave nail (HP:0001598)1.78060808
118Failure to thrive in infancy (HP:0001531)1.74924990
119Oligodactyly (hands) (HP:0001180)1.74841718
120Aplasia/Hypoplasia of the spleen (HP:0010451)1.74229322
121Methylmalonic acidemia (HP:0002912)1.74089558
122Retinitis pigmentosa (HP:0000510)1.74035818
123Drooling (HP:0002307)1.72792717
124Excessive salivation (HP:0003781)1.72792717
125Abnormal mitochondria in muscle tissue (HP:0008316)1.72345362
126Decreased central vision (HP:0007663)1.72267947
127Depression (HP:0000716)1.72033529
128Progressive inability to walk (HP:0002505)1.70553128
129Dysmetria (HP:0001310)1.70412073
130Tubulointerstitial abnormality (HP:0001969)1.68855406
131Progressive macrocephaly (HP:0004481)1.67492630
132Fair hair (HP:0002286)1.66899756
133Abnormality of binocular vision (HP:0011514)1.66488657
134Diplopia (HP:0000651)1.66488657
135Impaired vibratory sensation (HP:0002495)1.65652654
136Hyperthyroidism (HP:0000836)1.64465121
137Median cleft lip (HP:0000161)1.63617042
138Poor eye contact (HP:0000817)1.59662158
139Generalized hypopigmentation of hair (HP:0011358)1.59222103
140Congenital hepatic fibrosis (HP:0002612)1.58029488
141Optic disc pallor (HP:0000543)1.57424879
142Recurrent sinusitis (HP:0011108)1.57380786
143Agitation (HP:0000713)1.57370790
144Chronic sinusitis (HP:0011109)1.56538724
145Abnormality of calcium-phosphate metabolism (HP:0100530)1.56506832
146Fetal akinesia sequence (HP:0001989)1.56501130
147Bronchitis (HP:0012387)1.55787209
148Poor suck (HP:0002033)1.55717657
149Gait ataxia (HP:0002066)1.55614915
150Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.55315249
151Dysdiadochokinesis (HP:0002075)1.54321627
152Type II lissencephaly (HP:0007260)1.54197485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.13737740
2CASK4.42586971
3MAP2K73.36192808
4MAP3K43.15904189
5EPHA43.14097157
6PDK43.11343568
7PDK33.11343568
8TAOK32.82882119
9MAP3K122.56355288
10MAP4K22.47359336
11DAPK22.42110646
12ZAK2.16246111
13PINK12.09648810
14CDK192.06218197
15TLK12.05939242
16GRK12.03641303
17ACVR1B1.98261884
18NUAK11.97725183
19PNCK1.95598544
20PRKD31.88557091
21RIPK41.81475995
22PLK21.76882916
23MAPK131.76748274
24PRPF4B1.76077397
25PDK21.74965182
26TNIK1.73768901
27MAP2K41.72133760
28PTK2B1.70769836
29DAPK11.64464757
30GRK51.63490041
31MINK11.55320890
32MAP3K91.53790837
33NTRK21.49878841
34CCNB11.45796417
35OXSR11.43354149
36NME11.43021315
37MARK11.41446636
38WNK41.29916754
39INSRR1.22866132
40TXK1.21700155
41PRKCG1.18426649
42TRIM281.18144219
43AKT31.12941377
44FGFR21.11584394
45CAMK2A1.10879634
46SIK31.10501962
47MKNK21.10319447
48PAK61.07259871
49CDK51.05837484
50DYRK21.03729700
51BMPR21.03110152
52STK381.02147930
53GRK71.00487946
54STK391.00047791
55TGFBR10.95880155
56ADRBK20.93664618
57MAP3K20.92131947
58WNK30.90788445
59FES0.89464264
60KSR10.88074116
61CAMK2B0.86811059
62MAPK150.86521000
63TESK10.79019161
64VRK10.78662297
65CAMKK20.78147516
66ARAF0.77929588
67SGK20.77459096
68EPHA30.76771805
69CDK30.76540505
70NTRK10.75889730
71STK160.73049895
72SGK4940.72858232
73SGK2230.72858232
74UHMK10.72613862
75FRK0.70458839
76TIE10.68410843
77MKNK10.66445897
78BRAF0.65597042
79CAMK10.64952251
80CDK180.63324218
81ICK0.62831376
82ERBB30.61607571
83CAMKK10.60144121
84PRKCE0.59376230
85PDK10.58862491
86BCR0.58591651
87SIK20.58551802
88CDK150.58324582
89CDK140.56121201
90PAK30.55406780
91PHKG20.54854635
92PHKG10.54854635
93CAMK2D0.54613138
94PLK30.54448332
95FER0.54144590
96SGK10.53767757
97ADRBK10.52620908
98DYRK1A0.52374725
99MAP2K60.52219448
100CAMK1G0.51962377
101CAMK2G0.50219971
102CDK11A0.48780701
103WNK10.47651104
104BCKDK0.47630737
105MAPKAPK50.47349525
106IRAK20.47343570
107FGR0.47105952
108PIK3CA0.46546647
109CSNK1A10.45963553
110KSR20.44588381
111BRSK20.43778134
112STK30.43157780
113CSNK1G10.42952567
114STK110.42770116
115PRKCH0.42089938
116MAP3K60.40621687
117PASK0.40596096
118MAP3K130.40440578
119PIK3CG0.39853665
120RPS6KA50.39539354
121EIF2AK30.38680399
122STK38L0.38581242
123PRKCA0.38456235
124BMPR1B0.37639538
125PRKACA0.37384391
126PLK40.35565068
127CSNK1G20.34859250
128IKBKB0.34379881
129PRKG10.34354058
130PRKCQ0.34000882
131IRAK10.33581454
132DAPK30.32500901
133TNK20.31846076
134MUSK0.31099955
135NLK0.30995049
136PDPK10.30710389
137CHEK20.30543515
138PRKAA10.30368038
139PRKAA20.30061545
140PKN10.29780348
141CSNK1G30.29409545
142PRKCZ0.28650780

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.04694929
2Synaptic vesicle cycle_Homo sapiens_hsa047213.67593189
3Amphetamine addiction_Homo sapiens_hsa050312.90138611
4Collecting duct acid secretion_Homo sapiens_hsa049662.80220167
5Olfactory transduction_Homo sapiens_hsa047402.71765841
6Circadian entrainment_Homo sapiens_hsa047132.70415242
7Butanoate metabolism_Homo sapiens_hsa006502.66427812
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64529610
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53889540
10Morphine addiction_Homo sapiens_hsa050322.50768565
11Long-term potentiation_Homo sapiens_hsa047202.44293847
12Taste transduction_Homo sapiens_hsa047422.41131333
13Glutamatergic synapse_Homo sapiens_hsa047242.39911469
14GABAergic synapse_Homo sapiens_hsa047272.39007592
15Insulin secretion_Homo sapiens_hsa049112.36219752
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24234805
17Dopaminergic synapse_Homo sapiens_hsa047282.07840787
18Cocaine addiction_Homo sapiens_hsa050302.07373053
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01599695
20Oxidative phosphorylation_Homo sapiens_hsa001901.97031052
21Renin secretion_Homo sapiens_hsa049241.92842552
22Serotonergic synapse_Homo sapiens_hsa047261.91058223
23Tryptophan metabolism_Homo sapiens_hsa003801.90149123
24Salivary secretion_Homo sapiens_hsa049701.89641464
25Nitrogen metabolism_Homo sapiens_hsa009101.87525319
26Phototransduction_Homo sapiens_hsa047441.81355244
27Selenocompound metabolism_Homo sapiens_hsa004501.81312485
28Calcium signaling pathway_Homo sapiens_hsa040201.74394367
29Vibrio cholerae infection_Homo sapiens_hsa051101.73076159
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66286174
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65078500
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60127836
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55164768
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54138995
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53536502
36Gastric acid secretion_Homo sapiens_hsa049711.53106078
37Protein export_Homo sapiens_hsa030601.51318960
38Cholinergic synapse_Homo sapiens_hsa047251.50972233
39Cardiac muscle contraction_Homo sapiens_hsa042601.48622071
40Huntingtons disease_Homo sapiens_hsa050161.43459763
41Alzheimers disease_Homo sapiens_hsa050101.39977832
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.39165850
43Long-term depression_Homo sapiens_hsa047301.37380162
44Parkinsons disease_Homo sapiens_hsa050121.37068167
45Homologous recombination_Homo sapiens_hsa034401.36832707
46Oxytocin signaling pathway_Homo sapiens_hsa049211.35194428
47ABC transporters_Homo sapiens_hsa020101.31660526
48Caffeine metabolism_Homo sapiens_hsa002321.31658832
49Propanoate metabolism_Homo sapiens_hsa006401.28999706
50Fanconi anemia pathway_Homo sapiens_hsa034601.25682253
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22316540
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20780820
53RNA polymerase_Homo sapiens_hsa030201.17053689
54cAMP signaling pathway_Homo sapiens_hsa040241.15362360
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15295859
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13315208
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.09125799
58Type II diabetes mellitus_Homo sapiens_hsa049301.07688459
59Glucagon signaling pathway_Homo sapiens_hsa049221.04996285
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04655765
61Arachidonic acid metabolism_Homo sapiens_hsa005901.02969053
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01290648
63Chemical carcinogenesis_Homo sapiens_hsa052041.01182345
64GnRH signaling pathway_Homo sapiens_hsa049120.97447089
65Histidine metabolism_Homo sapiens_hsa003400.97319234
66Peroxisome_Homo sapiens_hsa041460.96584993
67Retinol metabolism_Homo sapiens_hsa008300.95098104
68Estrogen signaling pathway_Homo sapiens_hsa049150.92410579
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91342719
70Gap junction_Homo sapiens_hsa045400.88340761
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.87379569
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85261851
73Axon guidance_Homo sapiens_hsa043600.84581258
74beta-Alanine metabolism_Homo sapiens_hsa004100.82307820
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81994244
76Rheumatoid arthritis_Homo sapiens_hsa053230.80979602
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80826092
78Oocyte meiosis_Homo sapiens_hsa041140.79224541
79Pyruvate metabolism_Homo sapiens_hsa006200.78882279
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78777379
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78639593
82Type I diabetes mellitus_Homo sapiens_hsa049400.76321460
83RNA degradation_Homo sapiens_hsa030180.75738325
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75339971
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75283450
86One carbon pool by folate_Homo sapiens_hsa006700.75258764
87Dorso-ventral axis formation_Homo sapiens_hsa043200.74696996
88Thyroid hormone synthesis_Homo sapiens_hsa049180.73470012
89Melanogenesis_Homo sapiens_hsa049160.72287883
90Pancreatic secretion_Homo sapiens_hsa049720.71282709
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69509169
92Fat digestion and absorption_Homo sapiens_hsa049750.69070145
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68992544
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67924371
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62912953
96Fatty acid degradation_Homo sapiens_hsa000710.62187094
97Circadian rhythm_Homo sapiens_hsa047100.62159226
98Inositol phosphate metabolism_Homo sapiens_hsa005620.60239146
99Alcoholism_Homo sapiens_hsa050340.58923292
100Glycerolipid metabolism_Homo sapiens_hsa005610.58665021
101ErbB signaling pathway_Homo sapiens_hsa040120.58494151
102Vitamin digestion and absorption_Homo sapiens_hsa049770.57631896
103Purine metabolism_Homo sapiens_hsa002300.57402778
104Metabolic pathways_Homo sapiens_hsa011000.57308946
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57133645
106MAPK signaling pathway_Homo sapiens_hsa040100.53131002
107Sulfur metabolism_Homo sapiens_hsa009200.52304592
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.51284645
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50980546
110Phagosome_Homo sapiens_hsa041450.50034251
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49238995
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47318156
113Fatty acid metabolism_Homo sapiens_hsa012120.46940510
114Vitamin B6 metabolism_Homo sapiens_hsa007500.45587228
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44844326
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43956961
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.43947167
118African trypanosomiasis_Homo sapiens_hsa051430.43863309
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42606053
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.42416557
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40515764
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40357538
123Dilated cardiomyopathy_Homo sapiens_hsa054140.40106288
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.40073402
125Mineral absorption_Homo sapiens_hsa049780.39657432
126Ras signaling pathway_Homo sapiens_hsa040140.37104284
127Ovarian steroidogenesis_Homo sapiens_hsa049130.36021803
128Fatty acid biosynthesis_Homo sapiens_hsa000610.35334464
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35057691
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.34270102
131Glioma_Homo sapiens_hsa052140.33559852
132Wnt signaling pathway_Homo sapiens_hsa043100.33107854
133Ether lipid metabolism_Homo sapiens_hsa005650.32506405
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31958175
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30654958
136Choline metabolism in cancer_Homo sapiens_hsa052310.28066290
137Steroid biosynthesis_Homo sapiens_hsa001000.26108171
138Prion diseases_Homo sapiens_hsa050200.24501555
139Basal transcription factors_Homo sapiens_hsa030220.24431828
140Regulation of autophagy_Homo sapiens_hsa041400.23774426
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22497044
142Fructose and mannose metabolism_Homo sapiens_hsa000510.21277297
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20081421
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19703567
145Linoleic acid metabolism_Homo sapiens_hsa005910.18970502
146Hedgehog signaling pathway_Homo sapiens_hsa043400.16653048
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15848838

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