AGER

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vasculogenesis (GO:2001212)7.12983710
2regulation of glomerular filtration (GO:0003093)6.75618201
3regulation of integrin-mediated signaling pathway (GO:2001044)6.23048907
4positive regulation of endothelial cell differentiation (GO:0045603)6.06507618
5lymphangiogenesis (GO:0001946)5.91945726
6dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.54367097
7renal system process involved in regulation of blood volume (GO:0001977)5.50781196
8cellular response to nitric oxide (GO:0071732)5.50558586
9regulation of endothelial cell differentiation (GO:0045601)5.46008151
10response to xenobiotic stimulus (GO:0009410)5.27883455
11morphogenesis of an endothelium (GO:0003159)5.11535889
12endothelial tube morphogenesis (GO:0061154)5.11535889
13negative regulation of complement activation (GO:0045916)4.99656914
14lung lobe morphogenesis (GO:0060463)4.87674426
15positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.82365792
16phosphate ion transmembrane transport (GO:0035435)4.64123021
17negative regulation of humoral immune response (GO:0002921)4.58921009
18blood vessel maturation (GO:0001955)4.49681654
19negative regulation of protein activation cascade (GO:2000258)4.41690232
20wound healing, spreading of epidermal cells (GO:0035313)4.32553430
21regulation of cardioblast differentiation (GO:0051890)4.31763411
22calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.31512450
23renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)4.30942450
24lung vasculature development (GO:0060426)4.24154055
25peptide catabolic process (GO:0043171)4.23184329
26tight junction assembly (GO:0070830)4.21359261
27response to nitric oxide (GO:0071731)4.19848005
28sodium ion homeostasis (GO:0055078)4.16918864
29regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00434.14244434
30cellular response to reactive nitrogen species (GO:1902170)4.12882041
31hemidesmosome assembly (GO:0031581)3.88957993
32phosphate ion transport (GO:0006817)3.74094362
33negative regulation of cell killing (GO:0031342)3.72267218
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.72267218
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69077997
36response to increased oxygen levels (GO:0036296)3.68797195
37response to hyperoxia (GO:0055093)3.68797195
38positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.63862390
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.62577884
40positive regulation of gamma-delta T cell activation (GO:0046645)3.61907774
41establishment of apical/basal cell polarity (GO:0035089)3.61300661
42positive regulation of vasculogenesis (GO:2001214)3.58246635
43adhesion of symbiont to host cell (GO:0044650)3.57676591
44virion attachment to host cell (GO:0019062)3.57676591
45antigen processing and presentation of endogenous antigen (GO:0019883)3.57323186
46glomerular epithelial cell development (GO:0072310)3.53218837
47cellular hyperosmotic response (GO:0071474)3.49149910
48endocardial cushion development (GO:0003197)3.48459946
49positive regulation of p38MAPK cascade (GO:1900745)3.44020350
50negative regulation of stress fiber assembly (GO:0051497)3.43739597
51hydrogen peroxide biosynthetic process (GO:0050665)3.41201977
52cell adhesion mediated by integrin (GO:0033627)3.40894000
53respiratory tube development (GO:0030323)3.40315207
54cellular extravasation (GO:0045123)3.38811185
55vascular endothelial growth factor signaling pathway (GO:0038084)3.38682565
56neutrophil activation involved in immune response (GO:0002283)3.38467242
57negative regulation of interleukin-2 production (GO:0032703)3.31935439
58mesodermal cell differentiation (GO:0048333)3.31099291
59lung alveolus development (GO:0048286)3.31063567
60artery development (GO:0060840)3.30736566
61epithelial tube branching involved in lung morphogenesis (GO:0060441)3.29367176
62glomerular visceral epithelial cell development (GO:0072015)3.28219903
63wound healing, spreading of cells (GO:0044319)3.25462662
64negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.23341431
65regulation of gamma-delta T cell activation (GO:0046643)3.17042233
66regulation of tight junction assembly (GO:2000810)3.13018011
67regulation of gamma-delta T cell differentiation (GO:0045586)3.12291731
68one-carbon compound transport (GO:0019755)3.11441546
69establishment of monopolar cell polarity (GO:0061162)3.07346181
70establishment or maintenance of monopolar cell polarity (GO:0061339)3.07346181
71negative regulation of axon extension involved in axon guidance (GO:0048843)3.06070216
72gas transport (GO:0015669)3.04637831
73adhesion of symbiont to host (GO:0044406)3.03300862
74establishment of epithelial cell polarity (GO:0090162)3.02370794
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.02107038
76reactive oxygen species biosynthetic process (GO:1903409)3.00730439
77endothelial cell chemotaxis (GO:0035767)3.00421297
78respiratory gaseous exchange (GO:0007585)2.99744348
79embryonic foregut morphogenesis (GO:0048617)2.98974908
80blood vessel remodeling (GO:0001974)2.97860454
81regulation of T-helper 2 cell differentiation (GO:0045628)2.97783091
82macrophage chemotaxis (GO:0048246)2.97275316
83regulation of axon extension involved in axon guidance (GO:0048841)2.96612021
84response to laminar fluid shear stress (GO:0034616)2.95894385
85negative regulation of actin filament bundle assembly (GO:0032232)2.95790073
86positive regulation of blood coagulation (GO:0030194)2.95174420
87positive regulation of hemostasis (GO:1900048)2.95174420
88regulation of interleukin-13 production (GO:0032656)2.95142106
89regulation of dendritic cell antigen processing and presentation (GO:0002604)2.94810657
90sphingosine metabolic process (GO:0006670)2.94232325
91production of molecular mediator involved in inflammatory response (GO:0002532)2.93220763
92cellular response to thyroid hormone stimulus (GO:0097067)2.92996565
93regulation of podosome assembly (GO:0071801)2.92901545
94negative regulation of cell fate specification (GO:0009996)2.92823518
95detection of other organism (GO:0098543)2.92624715
96response to interleukin-6 (GO:0070741)2.91904824
97pattern specification involved in kidney development (GO:0061004)2.90352462
98renal filtration (GO:0097205)2.88222707
99cell-cell junction assembly (GO:0007043)2.87777550
100negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.86856764
101negative regulation of erythrocyte differentiation (GO:0045647)2.86809644
102detection of bacterium (GO:0016045)2.86717870
103endothelial cell differentiation (GO:0045446)2.85316636
104positive regulation of wound healing (GO:0090303)2.83232508
105negative regulation of endothelial cell proliferation (GO:0001937)2.82212077
106response to vitamin A (GO:0033189)2.81771884
107sodium-independent organic anion transport (GO:0043252)2.81516952
108negative regulation of glycoprotein biosynthetic process (GO:0010561)2.80564158
109basement membrane organization (GO:0071711)2.79684969
110macrophage activation involved in immune response (GO:0002281)2.79115565
111regulation of interleukin-2 biosynthetic process (GO:0045076)2.78151640
112multicellular organismal water homeostasis (GO:0050891)2.76884327
113positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.75687035
114protein localization to endosome (GO:0036010)2.75462786
115superoxide anion generation (GO:0042554)2.75349588
116positive regulation of type 2 immune response (GO:0002830)2.75343680
117negative regulation of lymphocyte mediated immunity (GO:0002707)2.73455315
118glomerular basement membrane development (GO:0032836)2.72980922
119germinal center formation (GO:0002467)2.72787808
120regulation of hippo signaling (GO:0035330)2.71577764
121regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71566685
122cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.71423724
123response to muramyl dipeptide (GO:0032495)2.71238018
124positive regulation of digestive system process (GO:0060456)2.70831795
125modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.70588063
126positive regulation by organism of defense response of other organism involved in symbiotic interact2.70588063
127modulation by symbiont of host immune response (GO:0052553)2.70588063
128positive regulation by symbiont of host defense response (GO:0052509)2.70588063
129modulation by symbiont of host defense response (GO:0052031)2.70588063
130modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.70588063
131hormone catabolic process (GO:0042447)2.67314200
132peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.65883913
133positive regulation of cell-matrix adhesion (GO:0001954)2.65299615
134positive regulation of coagulation (GO:0050820)2.64643851
135regulation of p38MAPK cascade (GO:1900744)2.64140880
136auditory receptor cell stereocilium organization (GO:0060088)2.63914310
137positive thymic T cell selection (GO:0045059)2.63833882
138response to peptidoglycan (GO:0032494)2.63338190
139negative regulation of transcription by competitive promoter binding (GO:0010944)2.63316346
140lymph vessel development (GO:0001945)2.62662303
141membrane raft organization (GO:0031579)2.62198879
142renal absorption (GO:0070293)2.61977303
143phosphate ion homeostasis (GO:0055062)2.61533861
144trivalent inorganic anion homeostasis (GO:0072506)2.61533861
145polarized epithelial cell differentiation (GO:0030859)2.60830504
146neuron projection extension involved in neuron projection guidance (GO:1902284)2.54677763
147axon extension involved in axon guidance (GO:0048846)2.54677763
148regulation of axon guidance (GO:1902667)2.54379417
149negative regulation of immunoglobulin mediated immune response (GO:0002890)2.52295611
150negative regulation of B cell mediated immunity (GO:0002713)2.52295611
151immunoglobulin mediated immune response (GO:0016064)2.49593730
152T cell mediated immunity (GO:0002456)2.49486297
153negative regulation of interleukin-12 production (GO:0032695)2.49175666
154positive regulation of tolerance induction (GO:0002645)2.47578773
155regulation of complement activation (GO:0030449)2.47557820
156interferon-gamma-mediated signaling pathway (GO:0060333)2.45302290
157regulation of tolerance induction (GO:0002643)2.44854901
158negative regulation of leukocyte mediated immunity (GO:0002704)2.44699222
159regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.44603689
160regulation of T cell tolerance induction (GO:0002664)2.44221102
161regulation of B cell receptor signaling pathway (GO:0050855)2.43467085
162negative regulation of interleukin-8 production (GO:0032717)2.43440916
163establishment of endothelial barrier (GO:0061028)2.43019197
164defense response to protozoan (GO:0042832)2.41154008
165interleukin-6-mediated signaling pathway (GO:0070102)2.39802820
166positive regulation of antigen processing and presentation (GO:0002579)2.39030228
167regulation of antigen processing and presentation (GO:0002577)2.38791003
168macrophage activation (GO:0042116)2.38774704
169endocrine hormone secretion (GO:0060986)2.37122200
170positive regulation of chemokine secretion (GO:0090197)2.35945452
171negative regulation of innate immune response (GO:0045824)2.35605392
172cellular response to antibiotic (GO:0071236)2.35411724
173hyperosmotic salinity response (GO:0042538)2.34678388
174polyol transport (GO:0015791)2.34375439
175surfactant homeostasis (GO:0043129)14.1733419
176chemical homeostasis within a tissue (GO:0048875)11.2745445

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.62193435
2GATA1_22025678_ChIP-Seq_K562_Human4.26344680
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.68569543
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.58820904
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.54969787
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.10594869
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08152057
8GATA2_21666600_ChIP-Seq_HMVEC_Human2.93753904
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.56379122
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.55838241
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.50555391
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.37648609
13RUNX_20019798_ChIP-Seq_JUKART_Human2.36798818
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36080445
15CLOCK_20551151_ChIP-Seq_293T_Human2.31378878
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.31128495
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27797610
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25919919
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.24026204
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.15868465
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13969453
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.06037036
23ESR1_21235772_ChIP-Seq_MCF-7_Human2.03616776
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.02074681
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.99826909
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.95547410
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.93143796
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92694408
29AHR_22903824_ChIP-Seq_MCF-7_Human1.91436123
30SCL_19346495_ChIP-Seq_HPC-7_Human1.87663858
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.85712917
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.84754088
33SOX2_20726797_ChIP-Seq_SW620_Human1.82733867
34VDR_24763502_ChIP-Seq_THP-1_Human1.79288995
35SALL4_18804426_ChIP-ChIP_XEN_Mouse1.78266042
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75053640
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74432669
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73468801
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61993506
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61769820
41TCF7_22412390_ChIP-Seq_EML_Mouse1.61731022
42SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61484607
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61484607
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59997177
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.55573101
46GATA4_25053715_ChIP-Seq_YYC3_Human1.54506422
47CJUN_26792858_Chip-Seq_BT549_Human1.54453716
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53513181
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50452102
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.49248761
51VDR_24787735_ChIP-Seq_THP-1_Human1.49181034
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48996227
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.47963823
54KDM2B_26808549_Chip-Seq_DND41_Human1.47703105
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.46640096
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44717226
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44643436
58MAF_26560356_Chip-Seq_TH1_Human1.44331715
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44282537
60MYB_26560356_Chip-Seq_TH2_Human1.44002291
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41369948
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41126817
63VDR_21846776_ChIP-Seq_THP-1_Human1.41083697
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.40054570
65* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37105990
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36979203
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36031220
68RACK7_27058665_Chip-Seq_MCF-7_Human1.35012021
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34711365
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.34152113
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.32409242
72TBX20_22080862_ChIP-Seq_HEART_Mouse1.32409242
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32315143
74LXR_22158963_ChIP-Seq_LIVER_Mouse1.31625215
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31427136
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30053639
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29213670
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28720202
79TP53_18474530_ChIP-ChIP_U2OS_Human1.28487230
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28244611
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26199581
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25186678
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24114751
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.23612463
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23398778
86STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22256819
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21406679
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21202464
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20993714
90UTX_26944678_Chip-Seq_JUKART_Human1.20646369
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18779140
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.17652586
93LXR_22292898_ChIP-Seq_THP-1_Human1.17277843
94GATA1_19941826_ChIP-Seq_K562_Human1.17220307
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16408416
96KLF5_25053715_ChIP-Seq_YYC3_Human1.16374891
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16311302
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15959815
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.15535873
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15292481
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14868031
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14697710
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14201224
104GATA3_27048872_Chip-Seq_THYMUS_Human1.14088346
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10623049
106SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08874490
107KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08858684
108MYB_26560356_Chip-Seq_TH1_Human1.08170468
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07282714
110MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06511387
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04353038
112GATA2_19941826_ChIP-Seq_K562_Human1.04274016
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03166101
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02872045
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01847000
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01693690
117P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01209451
118RXR_22158963_ChIP-Seq_LIVER_Mouse1.01039366
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00861614
120STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00591478
121SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99966138
122FOXA2_19822575_ChIP-Seq_HepG2_Human0.99429959
123KDM2B_26808549_Chip-Seq_K562_Human0.98976385
124JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98035435
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.97781734
126SPI1_23547873_ChIP-Seq_NB4_Human0.97714051
127GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97635985
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97433443
129PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96785447
130WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96524899
131TP63_23658742_ChIP-Seq_EP156T_Human0.96447926
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96218832
133GATA3_24758297_ChIP-Seq_MCF-7_Human0.95126902
134EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95116530
135RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95116530
136SPI1_23127762_ChIP-Seq_K562_Human0.94986714
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94072855
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94072855
139SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93364415
140HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92789304
141* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92554704
142MYC_22102868_ChIP-Seq_BL_Human0.92074222
143CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91087415
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90181248
145EED_16625203_ChIP-ChIP_MESCs_Mouse0.89913523
146LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88059269
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.87910010
148FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87646849
149DROSHA_22980978_ChIP-Seq_HELA_Human0.87517789
150TP63_17297297_ChIP-ChIP_HaCaT_Human0.86736821
151SMAD_19615063_ChIP-ChIP_OVARY_Human0.86614968
152ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85492093
153* MAF_26560356_Chip-Seq_TH2_Human0.85259513

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog6.67885408
2MP0001958_emphysema6.52238978
3MP0010368_abnormal_lymphatic_system5.30510266
4MP0008995_early_reproductive_senescence4.58471730
5MP0001879_abnormal_lymphatic_vessel3.86848224
6MP0005083_abnormal_biliary_tract3.79165671
7MP0002138_abnormal_hepatobiliary_system3.37941880
8MP0006054_spinal_hemorrhage3.35868440
9MP0003191_abnormal_cellular_cholesterol3.06312389
10MP0004272_abnormal_basement_membrane2.84747665
11MP0005388_respiratory_system_phenotype2.70812893
12MP0002133_abnormal_respiratory_system2.70812893
13MP0005167_abnormal_blood-brain_barrier2.55300191
14MP0001177_atelectasis2.53664223
15MP0009780_abnormal_chondrocyte_physiolo2.45346826
16MP0003436_decreased_susceptibility_to2.40413392
17MP0002132_abnormal_respiratory_system2.28594428
18MP0002419_abnormal_innate_immunity2.01932589
19MP0009379_abnormal_foot_pigmentation2.00107106
20MP0003941_abnormal_skin_development1.99992623
21MP0002295_abnormal_pulmonary_circulatio1.98393202
22MP0008875_abnormal_xenobiotic_pharmacok1.97868256
23MP0003724_increased_susceptibility_to1.97120789
24MP0005025_abnormal_response_to1.93599506
25MP0001835_abnormal_antigen_presentation1.92496913
26MP0008004_abnormal_stomach_pH1.88894214
27MP0003950_abnormal_plasma_membrane1.87522404
28MP0001545_abnormal_hematopoietic_system1.77190050
29MP0005397_hematopoietic_system_phenotyp1.77190050
30MP0001986_abnormal_taste_sensitivity1.66418340
31MP0003566_abnormal_cell_adhesion1.65905375
32MP0001175_abnormal_lung_morphology1.62797206
33MP0006082_CNS_inflammation1.58886655
34* MP0002723_abnormal_immune_serum1.53912983
35MP0003115_abnormal_respiratory_system1.53441676
36MP0001800_abnormal_humoral_immune1.50943171
37MP0005000_abnormal_immune_tolerance1.49281481
38MP0002452_abnormal_antigen_presenting1.47750586
39MP0009785_altered_susceptibility_to1.45635165
40MP0001533_abnormal_skeleton_physiology1.42374274
41MP0002420_abnormal_adaptive_immunity1.40048820
42MP0002254_reproductive_system_inflammat1.39806598
43MP0003828_pulmonary_edema1.38172934
44MP0001819_abnormal_immune_cell1.37577263
45MP0003705_abnormal_hypodermis_morpholog1.36769686
46MP0002277_abnormal_respiratory_mucosa1.36161574
47MP0009384_cardiac_valve_regurgitation1.35910888
48MP0000537_abnormal_urethra_morphology1.35665546
49MP0000767_abnormal_smooth_muscle1.35160948
50MP0003690_abnormal_glial_cell1.34542126
51MP0005275_abnormal_skin_tensile1.32672633
52* MP0004883_abnormal_blood_vessel1.24018104
53MP0000343_altered_response_to1.20111880
54MP0009278_abnormal_bone_marrow1.14768111
55* MP0005164_abnormal_response_to1.12149804
56MP0002166_altered_tumor_susceptibility1.12102201
57* MP0002998_abnormal_bone_remodeling1.11198905
58MP0001440_abnormal_grooming_behavior1.10836769
59MP0005023_abnormal_wound_healing1.10466143
60MP0003763_abnormal_thymus_physiology1.08675392
61MP0002148_abnormal_hypersensitivity_rea1.08610011
62MP0001853_heart_inflammation1.07870836
63MP0006138_congestive_heart_failure1.07277618
64MP0005671_abnormal_response_to1.06615752
65MP0005085_abnormal_gallbladder_physiolo1.05477794
66MP0001845_abnormal_inflammatory_respons1.02850385
67MP0005408_hypopigmentation1.02846843
68MP0003303_peritoneal_inflammation1.02496295
69* MP0000249_abnormal_blood_vessel1.02134052
70MP0008260_abnormal_autophagy1.01089380
71MP0009840_abnormal_foam_cell1.00627719
72* MP0005595_abnormal_vascular_smooth0.99422718
73* MP0000716_abnormal_immune_system0.98110467
74MP0002933_joint_inflammation0.97340038
75MP0003786_premature_aging0.97169177
76MP0008469_abnormal_protein_level0.95157671
77MP0002009_preneoplasia0.92159461
78MP0003656_abnormal_erythrocyte_physiolo0.91471300
79MP0003279_aneurysm0.90720840
80MP0002139_abnormal_hepatobiliary_system0.88619669
81MP0004084_abnormal_cardiac_muscle0.88468435
82MP0003448_altered_tumor_morphology0.88109742
83MP0001756_abnormal_urination0.87128993
84MP0002405_respiratory_system_inflammati0.87089902
85MP0000534_abnormal_ureter_morphology0.85730270
86MP0009764_decreased_sensitivity_to0.84647494
87MP0000681_abnormal_thyroid_gland0.82993332
88MP0002398_abnormal_bone_marrow0.81886057
89* MP0002925_abnormal_cardiovascular_devel0.81524080
90MP0000465_gastrointestinal_hemorrhage0.80663187
91MP0000685_abnormal_immune_system0.80387182
92MP0005464_abnormal_platelet_physiology0.80018142
93MP0003045_fibrosis0.79176640
94MP0001544_abnormal_cardiovascular_syste0.78966267
95MP0005385_cardiovascular_system_phenoty0.78966267
96MP0002168_other_aberrant_phenotype0.77957368
97* MP0002429_abnormal_blood_cell0.76240197
98MP0002128_abnormal_blood_circulation0.76206734
99MP0000566_synostosis0.75992244
100MP0001501_abnormal_sleep_pattern0.75480122
101MP0003453_abnormal_keratinocyte_physiol0.75085170
102MP0005165_increased_susceptibility_to0.74122367
103* MP0003091_abnormal_cell_migration0.73760419
104MP0005076_abnormal_cell_differentiation0.73579404
105MP0002722_abnormal_immune_system0.73219584
106MP0005166_decreased_susceptibility_to0.72851885
107MP0003075_altered_response_to0.72823734
108MP0002796_impaired_skin_barrier0.71618604
109MP0008775_abnormal_heart_ventricle0.71429966
110MP0010155_abnormal_intestine_physiology0.71189289
111MP0004858_abnormal_nervous_system0.71113532
112* MP0001614_abnormal_blood_vessel0.70645841
113MP0001666_abnormal_nutrient_absorption0.69972834
114MP0000689_abnormal_spleen_morphology0.69748043
115MP0001851_eye_inflammation0.68824312
116MP0010234_abnormal_vibrissa_follicle0.67524800
117* MP0002136_abnormal_kidney_physiology0.67435935
118MP0009333_abnormal_splenocyte_physiolog0.67230300
119* MP0009643_abnormal_urine_homeostasis0.64950120
120MP0003638_abnormal_response/metabolism_0.64844984
121MP0004808_abnormal_hematopoietic_stem0.64611800
122MP0000703_abnormal_thymus_morphology0.64315581
123MP0003866_abnormal_defecation0.62892198
124MP0000462_abnormal_digestive_system0.62484125
125MP0005248_abnormal_Harderian_gland0.62325428
126MP0002098_abnormal_vibrissa_morphology0.61957351
127MP0002332_abnormal_exercise_endurance0.61596414
128MP0003300_gastrointestinal_ulcer0.61461367
129MP0005058_abnormal_lysosome_morphology0.61225904
130MP0000604_amyloidosis0.60914700
131* MP0002135_abnormal_kidney_morphology0.60716779
132MP0001943_abnormal_respiration0.60540253
133MP0008438_abnormal_cutaneous_collagen0.60275784
134MP0002972_abnormal_cardiac_muscle0.59438128
135MP0004484_altered_response_of0.57366161
136* MP0005387_immune_system_phenotype0.57151648
137* MP0001790_abnormal_immune_system0.57151648
138MP0005360_urolithiasis0.56773453
139MP0001881_abnormal_mammary_gland0.54264005
140MP0002118_abnormal_lipid_homeostasis0.54160776
141MP0000627_abnormal_mammary_gland0.52079369
142MP0002127_abnormal_cardiovascular_syste0.51655227
143MP0005623_abnormal_meninges_morphology0.49546015
144MP0004947_skin_inflammation0.48902319
145MP0010678_abnormal_skin_adnexa0.48524951
146MP0004085_abnormal_heartbeat0.47749487

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)9.32577528
2Hyperactive renin-angiotensin system (HP:0000841)8.20148738
3Chronic bronchitis (HP:0004469)6.74967511
4Renal salt wasting (HP:0000127)6.26643881
5Abnormality of the fingertips (HP:0001211)5.68913517
6Hyperkalemia (HP:0002153)5.44947342
7Tubulointerstitial fibrosis (HP:0005576)5.32011522
8Polycythemia (HP:0001901)5.17482545
9Onycholysis (HP:0001806)5.09197300
10Broad metatarsal (HP:0001783)4.98453001
11Alveolar cell carcinoma (HP:0006519)4.68909180
12Tachypnea (HP:0002789)4.50141839
13Hematochezia (HP:0002573)4.44697244
14Neoplasm of the tracheobronchial system (HP:0100552)4.40330578
15Gout (HP:0001997)4.34067738
16Recurrent abscess formation (HP:0002722)4.33028394
17Systemic lupus erythematosus (HP:0002725)4.30425349
18Spontaneous hematomas (HP:0007420)4.11225141
19Decreased circulating renin level (HP:0003351)3.98493063
20Glomerulonephritis (HP:0000099)3.96458689
21Hyperaldosteronism (HP:0000859)3.88881899
22Abnormality of the nasal mucosa (HP:0000433)3.81095898
23Recurrent gram-negative bacterial infections (HP:0005420)3.69090896
24Respiratory distress (HP:0002098)3.65074228
25Tubulointerstitial nephritis (HP:0001970)3.62481837
26Esophageal varix (HP:0002040)3.47101558
27Hypotension (HP:0002615)3.46508821
28Abnormality of renin-angiotensin system (HP:0000847)3.39391936
29Shallow orbits (HP:0000586)3.35537616
30Segmental peripheral demyelination/remyelination (HP:0003481)3.28607753
31Abnormality of chloride homeostasis (HP:0011422)3.23438746
32Thin bony cortex (HP:0002753)3.16580508
33Bronchitis (HP:0012387)3.14393701
34Tubulointerstitial abnormality (HP:0001969)3.12643482
35Hypokalemic alkalosis (HP:0001949)3.11124331
36Hypergammaglobulinemia (HP:0010702)3.09277999
37Fragile nails (HP:0001808)3.04601752
38Pulmonary fibrosis (HP:0002206)3.01226633
39Myositis (HP:0100614)2.99785710
40Complement deficiency (HP:0004431)2.98514394
41Exertional dyspnea (HP:0002875)2.94723814
42Visceral angiomatosis (HP:0100761)2.90542759
43Recurrent bacterial skin infections (HP:0005406)2.88436015
44Neurofibrillary tangles (HP:0002185)2.87825527
45Hyponatremia (HP:0002902)2.87803165
46Abnormality of complement system (HP:0005339)2.79057186
47Atrophic scars (HP:0001075)2.78080497
48Abnormal umbilical cord blood vessels (HP:0011403)2.77904093
49Single umbilical artery (HP:0001195)2.77904093
50Abnormality of the fetal cardiovascular system (HP:0010948)2.77904093
51Vascular tortuosity (HP:0004948)2.76294826
52Conjunctival telangiectasia (HP:0000524)2.72802684
53Milia (HP:0001056)2.66918935
54Hemangiomatosis (HP:0007461)2.63392091
55Increased IgE level (HP:0003212)2.55251950
56Tubular atrophy (HP:0000092)2.49686903
57Orchitis (HP:0100796)2.48287549
58Broad ribs (HP:0000885)2.47446503
59Growth hormone excess (HP:0000845)2.47266339
60Pulmonary hypertension (HP:0002092)2.44466991
61Pulmonary artery stenosis (HP:0004415)2.43998916
62Adrenal overactivity (HP:0002717)2.42512734
63Potter facies (HP:0002009)2.41830779
64Facial shape deformation (HP:0011334)2.41830779
65Intestinal atresia (HP:0011100)2.39748111
66Prolonged bleeding time (HP:0003010)2.39735023
67Deep venous thrombosis (HP:0002625)2.38311533
68Cellulitis (HP:0100658)2.38286533
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.37830647
70Increased CSF protein (HP:0002922)2.37315097
71Neoplasm of the lung (HP:0100526)2.36731833
72Cerebral hemorrhage (HP:0001342)2.35997685
73Cortical dysplasia (HP:0002539)2.33103776
74Abnormality of sodium homeostasis (HP:0010931)2.32395131
75Abnormality of the vasculature of the conjunctiva (HP:0008054)2.32285753
76Gingivitis (HP:0000230)2.31787023
77Long toe (HP:0010511)2.30881164
78Recurrent fungal infections (HP:0002841)2.30382199
79Retrobulbar optic neuritis (HP:0100654)2.27353152
80Optic neuritis (HP:0100653)2.27353152
81Mediastinal lymphadenopathy (HP:0100721)2.26747010
82Elevated erythrocyte sedimentation rate (HP:0003565)2.25308046
83Keratoconjunctivitis sicca (HP:0001097)2.25109570
84Aortic valve stenosis (HP:0001650)2.23751028
85Pulmonary infiltrates (HP:0002113)2.23118769
86Restrictive lung disease (HP:0002091)2.22705077
87Cerebral inclusion bodies (HP:0100314)2.22572090
88Camptodactyly of toe (HP:0001836)2.20637460
89Bronchomalacia (HP:0002780)2.18419681
90Ulnar claw (HP:0001178)2.15583179
91Midline defect of the nose (HP:0004122)2.15415257
92Ulnar bowing (HP:0003031)2.15069107
93Pulmonary embolism (HP:0002204)2.09873450
94Aortic aneurysm (HP:0004942)2.08525812
95Glomerulosclerosis (HP:0000096)2.06314824
96Keratoconjunctivitis (HP:0001096)2.05159732
97Congenital malformation of the right heart (HP:0011723)2.04506675
98Double outlet right ventricle (HP:0001719)2.04506675
99Epistaxis (HP:0000421)2.04162938
100Glucose intolerance (HP:0000833)2.04088589
101Nephritis (HP:0000123)2.03749236
102Arterial tortuosity (HP:0005116)2.03181864
103Partial duplication of thumb phalanx (HP:0009944)2.02694992
104Meningitis (HP:0001287)2.02331778
105Cerebral aneurysm (HP:0004944)2.01333808
106Rectal prolapse (HP:0002035)1.99456530
107Osteomyelitis (HP:0002754)1.98417370
108Mitral regurgitation (HP:0001653)1.98400893
109Annular pancreas (HP:0001734)1.98344728
110Neoplasm of the respiratory system (HP:0100606)1.98301627
111Chronic obstructive pulmonary disease (HP:0006510)1.97511483
112Obstructive lung disease (HP:0006536)1.97511483
113Severe Myopia (HP:0011003)1.96426515
114Joint swelling (HP:0001386)1.95501395
115Vasculitis (HP:0002633)1.94909193
116Recurrent skin infections (HP:0001581)1.93844252
117Bronchiectasis (HP:0002110)1.92597159
118Colitis (HP:0002583)1.90812388
119Turricephaly (HP:0000262)1.90019657
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.89356414
121Osteolytic defects of the hand bones (HP:0009699)1.89356414
122Stage 5 chronic kidney disease (HP:0003774)1.89334790
123Palpebral edema (HP:0100540)1.88563877
124Neonatal respiratory distress (HP:0002643)1.86494602
125Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86266485
126Thyroid-stimulating hormone excess (HP:0002925)1.85943288
127Autoimmune thrombocytopenia (HP:0001973)1.85809333
128Rapidly progressive (HP:0003678)1.85483216
129Purpura (HP:0000979)1.85208836
130Hemoptysis (HP:0002105)1.84816130
131Shawl scrotum (HP:0000049)1.84355655
132Increased purine levels (HP:0004368)1.83403260
133Hyperuricemia (HP:0002149)1.83403260
134Plantar hyperkeratosis (HP:0007556)1.83199217
135Myocardial infarction (HP:0001658)1.83024359
136Pustule (HP:0200039)1.83014424
137Emphysema (HP:0002097)1.82873233
138Bowing of the arm (HP:0006488)1.82573552
139Bowed forearm bones (HP:0003956)1.82573552
140Eczematoid dermatitis (HP:0000976)1.82383496
141Abnormality of macrophages (HP:0004311)1.81153905
142Stenosis of the external auditory canal (HP:0000402)1.80757249
143Joint contractures involving the joints of the feet (HP:0100492)1.80703753
144Flexion contracture of toe (HP:0005830)1.80703753
145Onion bulb formation (HP:0003383)1.80681013
146Chronic mucocutaneous candidiasis (HP:0002728)1.79666776
147Recurrent cutaneous fungal infections (HP:0011370)1.79666776
148Seborrheic dermatitis (HP:0001051)1.79664743
149Abnormal cartilage morphology (HP:0002763)1.78549992
150Abnormality of the renal cortex (HP:0011035)1.78342118
151Microcytic anemia (HP:0001935)1.78093278
152Granulocytopenia (HP:0001913)1.77685195
153Gastrointestinal infarctions (HP:0005244)1.77215861
154Acne (HP:0001061)1.76683158
155Portal hypertension (HP:0001409)1.75592729
156Abnormality of the pulmonary veins (HP:0011718)1.74974508
157Xerostomia (HP:0000217)1.74832298
158Malnutrition (HP:0004395)1.74398941
159Increased cerebral lipofuscin (HP:0011813)1.73851543
160Stomatitis (HP:0010280)1.72752440
161Abnormality of potassium homeostasis (HP:0011042)1.72325251
162Adactyly (HP:0009776)1.71467680
163Mucosal telangiectasiae (HP:0100579)1.71462393
164Joint hemorrhage (HP:0005261)1.70381951
165Increased connective tissue (HP:0009025)1.68219358
166Absent hand (HP:0004050)1.67612869
167Prostate neoplasm (HP:0100787)1.67329809
168Striae distensae (HP:0001065)1.64436133
169Inflammation of the large intestine (HP:0002037)1.64127574
170Papilledema (HP:0001085)1.63472020
171Verrucae (HP:0200043)1.62569939
172Papilloma (HP:0012740)1.62569939
173Acrocyanosis (HP:0001063)1.61787474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.55665492
2TGFBR24.63562819
3MAP3K33.64845304
4MAP2K33.03942635
5TAOK12.79882586
6TESK12.76714774
7TAOK22.75905743
8DAPK22.74820927
9EPHB22.67785390
10RIPK42.58578786
11LRRK22.57042495
12PRPF4B2.55724962
13MAP3K112.35313089
14STK102.30103857
15FGFR22.27943979
16MAP4K12.26573782
17EPHB12.17002363
18TYK22.14765606
19LIMK12.14422452
20MAP3K62.00097490
21ZAP701.99444998
22TRIB31.88872935
23BLK1.86914254
24MST41.79777138
25MAP3K141.75719453
26EPHA21.68705246
27PAK41.67691956
28RIPK11.65595885
29MAP3K131.64198588
30FES1.63295678
31ILK1.61331312
32STK241.59702540
33MYLK1.51772103
34NUAK11.50792412
35FER1.46879844
36NLK1.46866593
37IRAK41.43657782
38MAP3K121.42902039
39GRK11.39470148
40GRK71.39296064
41FGFR41.38705473
42PDGFRB1.38035793
43IRAK11.33493127
44CDC42BPA1.31064186
45TBK11.29593612
46CSK1.28916892
47RPS6KA21.27617398
48TGFBR11.24225966
49MAP3K21.23518024
50KIT1.20885284
51ERN11.20572343
52PTK61.10994948
53HCK1.09083583
54GRK51.07675838
55MAPK71.06901800
56MAP3K11.04507368
57JAK31.01405855
58BTK1.00440487
59MAPK120.99537092
60YES10.97997189
61EGFR0.94645909
62TNK20.90436827
63RPS6KL10.85214263
64RPS6KC10.85214263
65SGK30.84437912
66EPHA30.81784990
67MOS0.81453499
68PRKD10.80857262
69AKT30.80222516
70LCK0.79979143
71KDR0.79764398
72FGFR30.79019800
73PDK10.78783220
74PDGFRA0.76665085
75SGK20.76358412
76LYN0.76041885
77SYK0.75537616
78TXK0.73850370
79LATS10.73821969
80RPS6KA60.72482815
81NEK90.70773219
82KSR20.70645023
83CSF1R0.69826974
84MAPK150.69509713
85GSK3A0.67717928
86PRKCH0.67393645
87ITK0.66108754
88PTK20.64921129
89RET0.62051141
90LMTK20.61273698
91SIK10.60042927
92IKBKB0.59799760
93CDK60.59490833
94DAPK30.56733971
95MAP2K10.56192602
96ERBB30.55894420
97MAP2K20.54652715
98SGK2230.54539504
99SGK4940.54539504
100GRK60.54113716
101TTN0.53187730
102FGR0.53113908
103PKN20.51551074
104ROCK20.51237445
105MAP3K70.46332224
106MAPKAPK20.46267604
107DYRK1B0.44890148
108MAPK30.44876999
109DDR20.42693428
110MST1R0.42444319
111RPS6KA10.41314945
112PRKCE0.41089888
113PRKD20.40867615
114MAPK40.39545248
115MAP3K80.38911399
116MAP2K60.38459774
117IGF1R0.37608168
118CAMK10.36432722
119TRPM70.36030243
120ROCK10.35957269
121LATS20.34842254
122IKBKE0.34820975
123JAK20.34404805
124DMPK0.34305192
125HIPK20.34300950
126PTK2B0.33880341
127ABL10.31811269
128FYN0.30658956
129NTRK10.29834841
130MET0.28638476
131MATK0.28388068
132PRKCQ0.25703956
133SRC0.25576051
134DAPK10.23988350
135ERBB20.22459327
136MARK20.22229056
137BCR0.21744760
138INSR0.20336463
139TEC0.19486639
140JAK10.19004860
141TAOK30.18624831
142CHUK0.18203719
143ADRBK10.17365862
144PDPK10.16781269

Predicted pathways (KEGG)

RankGene SetZ-score
1Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.46371030
2Leukocyte transendothelial migration_Homo sapiens_hsa046702.87012665
3Adherens junction_Homo sapiens_hsa045202.83826516
4ECM-receptor interaction_Homo sapiens_hsa045122.77094783
5Tight junction_Homo sapiens_hsa045302.64263593
6Graft-versus-host disease_Homo sapiens_hsa053322.37239077
7Allograft rejection_Homo sapiens_hsa053302.32539942
8Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.28460995
9Autoimmune thyroid disease_Homo sapiens_hsa053202.14832015
10Osteoclast differentiation_Homo sapiens_hsa043802.12262708
11Bladder cancer_Homo sapiens_hsa052192.01391430
12Caffeine metabolism_Homo sapiens_hsa002321.91457073
13Asthma_Homo sapiens_hsa053101.89458477
14Focal adhesion_Homo sapiens_hsa045101.86222376
15* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.83818075
16Hippo signaling pathway_Homo sapiens_hsa043901.80452438
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.66835363
18Type I diabetes mellitus_Homo sapiens_hsa049401.63321003
19Mineral absorption_Homo sapiens_hsa049781.58453923
20Amoebiasis_Homo sapiens_hsa051461.53626619
21Proteoglycans in cancer_Homo sapiens_hsa052051.49669396
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47160187
23Rap1 signaling pathway_Homo sapiens_hsa040151.45193428
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39875366
25Hematopoietic cell lineage_Homo sapiens_hsa046401.39873564
26Antigen processing and presentation_Homo sapiens_hsa046121.38878036
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37042642
28B cell receptor signaling pathway_Homo sapiens_hsa046621.34044667
29Other glycan degradation_Homo sapiens_hsa005111.33378260
30Small cell lung cancer_Homo sapiens_hsa052221.32523509
31Renin-angiotensin system_Homo sapiens_hsa046141.31802707
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31395098
33Axon guidance_Homo sapiens_hsa043601.29690147
34Platelet activation_Homo sapiens_hsa046111.29605924
35Complement and coagulation cascades_Homo sapiens_hsa046101.28813584
36Viral myocarditis_Homo sapiens_hsa054161.26784051
37Lysosome_Homo sapiens_hsa041421.26780235
38Pertussis_Homo sapiens_hsa051331.26489390
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25407420
40Acute myeloid leukemia_Homo sapiens_hsa052211.24577890
41VEGF signaling pathway_Homo sapiens_hsa043701.23620391
42Influenza A_Homo sapiens_hsa051641.21942361
43Hepatitis C_Homo sapiens_hsa051601.18884389
44Histidine metabolism_Homo sapiens_hsa003401.18530600
45Phagosome_Homo sapiens_hsa041451.18514336
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16908718
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16426879
48Taste transduction_Homo sapiens_hsa047421.15727885
49Toxoplasmosis_Homo sapiens_hsa051451.15603328
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15267048
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.14642705
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.14552583
53Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12807588
54Malaria_Homo sapiens_hsa051441.12588435
55Chemokine signaling pathway_Homo sapiens_hsa040621.11717040
56Endocytosis_Homo sapiens_hsa041441.11513598
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11111108
58NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08388455
59NF-kappa B signaling pathway_Homo sapiens_hsa040641.06802869
60TGF-beta signaling pathway_Homo sapiens_hsa043501.04331146
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03636293
62Vibrio cholerae infection_Homo sapiens_hsa051101.03506260
63Sulfur metabolism_Homo sapiens_hsa009201.02642293
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02019842
65Herpes simplex infection_Homo sapiens_hsa051681.00720841
66Primary immunodeficiency_Homo sapiens_hsa053401.00058344
67Tryptophan metabolism_Homo sapiens_hsa003800.98606929
68Renin secretion_Homo sapiens_hsa049240.98578516
69Measles_Homo sapiens_hsa051620.97458600
70Pancreatic cancer_Homo sapiens_hsa052120.95918361
71ABC transporters_Homo sapiens_hsa020100.95629263
72Dilated cardiomyopathy_Homo sapiens_hsa054140.95143953
73T cell receptor signaling pathway_Homo sapiens_hsa046600.95015287
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91458449
75Salmonella infection_Homo sapiens_hsa051320.90077929
76Pathways in cancer_Homo sapiens_hsa052000.89203131
77Basal cell carcinoma_Homo sapiens_hsa052170.88884501
78Renal cell carcinoma_Homo sapiens_hsa052110.86037765
79Staphylococcus aureus infection_Homo sapiens_hsa051500.82806871
80Choline metabolism in cancer_Homo sapiens_hsa052310.81936196
81Salivary secretion_Homo sapiens_hsa049700.80848205
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78379958
83Melanogenesis_Homo sapiens_hsa049160.76743779
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.76730408
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76173340
86Fatty acid elongation_Homo sapiens_hsa000620.75894207
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75683130
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.75020409
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.74597836
90Endometrial cancer_Homo sapiens_hsa052130.73898215
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72356148
92Selenocompound metabolism_Homo sapiens_hsa004500.71486942
93GnRH signaling pathway_Homo sapiens_hsa049120.70065638
94Prolactin signaling pathway_Homo sapiens_hsa049170.69345256
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.69190575
96MAPK signaling pathway_Homo sapiens_hsa040100.67986754
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67354107
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.66598210
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66169194
100Insulin resistance_Homo sapiens_hsa049310.65375964
101Hepatitis B_Homo sapiens_hsa051610.64850474
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64299865
103Ether lipid metabolism_Homo sapiens_hsa005650.63372741
104Bile secretion_Homo sapiens_hsa049760.63198679
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62174646
106Protein digestion and absorption_Homo sapiens_hsa049740.62134132
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62082769
108Chemical carcinogenesis_Homo sapiens_hsa052040.61996050
109Rheumatoid arthritis_Homo sapiens_hsa053230.61723345
110Legionellosis_Homo sapiens_hsa051340.61103839
111Apoptosis_Homo sapiens_hsa042100.59075987
112Thyroid hormone synthesis_Homo sapiens_hsa049180.58988435
113Shigellosis_Homo sapiens_hsa051310.58904481
114TNF signaling pathway_Homo sapiens_hsa046680.58528915
115Chronic myeloid leukemia_Homo sapiens_hsa052200.58238834
116Leishmaniasis_Homo sapiens_hsa051400.57301046
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.56621014
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56303074
119FoxO signaling pathway_Homo sapiens_hsa040680.56246266
120Gastric acid secretion_Homo sapiens_hsa049710.56153749
121HTLV-I infection_Homo sapiens_hsa051660.55862133
122Non-small cell lung cancer_Homo sapiens_hsa052230.54666522
123Dorso-ventral axis formation_Homo sapiens_hsa043200.54231382
124Fatty acid biosynthesis_Homo sapiens_hsa000610.53872668
125Fatty acid degradation_Homo sapiens_hsa000710.53452347
126Gap junction_Homo sapiens_hsa045400.53346182
127MicroRNAs in cancer_Homo sapiens_hsa052060.52601342
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52413264
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52373389
130Notch signaling pathway_Homo sapiens_hsa043300.51938730
131mTOR signaling pathway_Homo sapiens_hsa041500.51919593
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50931230
133Tuberculosis_Homo sapiens_hsa051520.50874045
134Retinol metabolism_Homo sapiens_hsa008300.46336995
135Type II diabetes mellitus_Homo sapiens_hsa049300.46233886
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.45506368
137Prion diseases_Homo sapiens_hsa050200.43596171
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42364222
139Sphingolipid metabolism_Homo sapiens_hsa006000.41798943
140Ovarian steroidogenesis_Homo sapiens_hsa049130.41631857
141Ras signaling pathway_Homo sapiens_hsa040140.39935725
142Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39668107
143Estrogen signaling pathway_Homo sapiens_hsa049150.35691594
144African trypanosomiasis_Homo sapiens_hsa051430.35632881
145Colorectal cancer_Homo sapiens_hsa052100.35605015
146Hedgehog signaling pathway_Homo sapiens_hsa043400.35268923

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