AGFG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.53991220
2negative regulation of cell killing (GO:0031342)4.53991220
3embryonic process involved in female pregnancy (GO:0060136)3.93222736
4nuclear pore complex assembly (GO:0051292)3.73417108
5cytoplasmic mRNA processing body assembly (GO:0033962)3.71874118
6pre-miRNA processing (GO:0031054)3.67569159
7negative regulation of erythrocyte differentiation (GO:0045647)3.51429750
8NLS-bearing protein import into nucleus (GO:0006607)3.49666898
9response to peptidoglycan (GO:0032494)3.46933418
10detection of molecule of bacterial origin (GO:0032490)3.36213933
11regulation of RNA export from nucleus (GO:0046831)3.30412887
12nuclear pore organization (GO:0006999)3.23696429
13nerve growth factor signaling pathway (GO:0038180)3.21718004
14protein localization to endosome (GO:0036010)3.20760916
15cytoskeletal anchoring at plasma membrane (GO:0007016)3.19616944
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.18752684
17locomotory exploration behavior (GO:0035641)3.16095610
18positive regulation of cellular amide metabolic process (GO:0034250)3.10693429
19layer formation in cerebral cortex (GO:0021819)3.10042325
20negative regulation of neurotransmitter secretion (GO:0046929)3.08995908
21positive T cell selection (GO:0043368)3.02891577
22regulation of nucleobase-containing compound transport (GO:0032239)3.02384630
23mitotic sister chromatid cohesion (GO:0007064)3.01902366
24vesicle transport along microtubule (GO:0047496)2.96343063
25regulation of clathrin-mediated endocytosis (GO:2000369)2.96129736
26response to laminar fluid shear stress (GO:0034616)2.95981536
27hypotonic response (GO:0006971)2.94087614
28cellular response to ethanol (GO:0071361)2.92319582
29signal complex assembly (GO:0007172)2.86424776
30positive thymic T cell selection (GO:0045059)2.83161757
31positive regulation by symbiont of host defense response (GO:0052509)2.81855094
32modulation by symbiont of host defense response (GO:0052031)2.81855094
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81855094
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81855094
35positive regulation by organism of defense response of other organism involved in symbiotic interact2.81855094
36modulation by symbiont of host immune response (GO:0052553)2.81855094
37response to muramyl dipeptide (GO:0032495)2.80043156
38peptidyl-lysine dimethylation (GO:0018027)2.79468346
39response to nerve growth factor (GO:1990089)2.75178805
40cellular response to nerve growth factor stimulus (GO:1990090)2.75178805
41regulation of translational termination (GO:0006449)2.74184219
42lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73960285
43cellular extravasation (GO:0045123)2.73942766
44negative regulation of histone methylation (GO:0031061)2.71521723
45synaptic vesicle maturation (GO:0016188)2.70630005
46peptidyl-threonine phosphorylation (GO:0018107)2.70313590
47pinocytosis (GO:0006907)2.67487490
48macrophage activation involved in immune response (GO:0002281)2.67439354
49peptidyl-threonine modification (GO:0018210)2.65977423
50pore complex assembly (GO:0046931)2.64865817
51regulation of early endosome to late endosome transport (GO:2000641)2.63632609
52positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.62183680
53germinal center formation (GO:0002467)2.60554741
54clathrin coat assembly (GO:0048268)2.60403026
55negative T cell selection (GO:0043383)2.60380606
56regulation of transforming growth factor beta2 production (GO:0032909)2.59790979
57negative regulation of interleukin-12 production (GO:0032695)2.58965311
58corticosteroid receptor signaling pathway (GO:0031958)2.56598196
59negative thymic T cell selection (GO:0045060)2.56014893
60detection of external biotic stimulus (GO:0098581)2.55992658
61regulation of ARF protein signal transduction (GO:0032012)2.55258694
62detection of other organism (GO:0098543)2.53529452
63negative regulation of fatty acid transport (GO:2000192)2.53412174
64glucocorticoid receptor signaling pathway (GO:0042921)2.53357478
65response to host (GO:0075136)2.52705876
66response to host defenses (GO:0052200)2.52705876
67response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.52705876
68histone H3-K9 demethylation (GO:0033169)2.52630156
69spindle assembly involved in mitosis (GO:0090307)2.52615059
70regulation of NFAT protein import into nucleus (GO:0051532)2.52162242
71regulation of histone H3-K27 methylation (GO:0061085)2.50154239
72growth hormone receptor signaling pathway (GO:0060396)2.48720023
73mannose metabolic process (GO:0006013)2.48086283
74organelle transport along microtubule (GO:0072384)2.47600841
75monoubiquitinated protein deubiquitination (GO:0035520)2.46329036
76regulation of translational fidelity (GO:0006450)2.46055008
77mRNA transcription (GO:0009299)2.46006635
78neutrophil activation involved in immune response (GO:0002283)2.45843565
79histone H3-K36 demethylation (GO:0070544)2.44996600
80thymic T cell selection (GO:0045061)2.43643528
81regulation of T-helper 2 cell differentiation (GO:0045628)2.43608643
82T cell selection (GO:0045058)2.43524150
83regulation of short-term neuronal synaptic plasticity (GO:0048172)2.42295003
84sodium ion export (GO:0071436)2.41435682
85establishment of nucleus localization (GO:0040023)2.40611346
86low-density lipoprotein particle clearance (GO:0034383)2.40429754
87positive regulation of endothelial cell apoptotic process (GO:2000353)2.37544781
88modulation by symbiont of host cellular process (GO:0044068)2.37442431
89detection of biotic stimulus (GO:0009595)2.35966948
90cell-substrate adherens junction assembly (GO:0007045)2.35498404
91focal adhesion assembly (GO:0048041)2.35498404
92JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.35379030
93cell-substrate junction assembly (GO:0007044)2.34898754
94cell adhesion mediated by integrin (GO:0033627)2.34829018
95regulation of transforming growth factor beta1 production (GO:0032908)2.34239885
96activated T cell proliferation (GO:0050798)2.34049339
97histone H2A monoubiquitination (GO:0035518)2.33280226
98positive regulation of histone deacetylation (GO:0031065)2.32841718
99establishment of protein localization to Golgi (GO:0072600)2.32095076
100regulation of macrophage cytokine production (GO:0010935)2.31964981
101protein targeting to Golgi (GO:0000042)2.31214298
102chromatin assembly (GO:0031497)2.30259319
103microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.30022712
104membrane raft organization (GO:0031579)2.29787577
105response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.28778861
106response to host immune response (GO:0052572)2.28778861
107positive regulation of extracellular matrix organization (GO:1903055)2.28469833
108Rap protein signal transduction (GO:0032486)2.28212586
109negative regulation of anoikis (GO:2000811)2.28119976
110mRNA stabilization (GO:0048255)2.26603464
111RNA stabilization (GO:0043489)2.26603464
112T cell costimulation (GO:0031295)2.25571021
113positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.25471501
114heterochromatin organization (GO:0070828)2.24344240
115regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.23925992
116regulation of synaptic vesicle exocytosis (GO:2000300)2.23679159
117regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.23267484
118positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.23267484
119negative regulation of inclusion body assembly (GO:0090084)2.22064058
120negative regulation of toll-like receptor signaling pathway (GO:0034122)2.22021787
121cortical cytoskeleton organization (GO:0030865)2.21427508
122lymphocyte costimulation (GO:0031294)2.20701884
123phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.20350420
124negative regulation of organelle assembly (GO:1902116)2.19506103
125cellular response to thyroid hormone stimulus (GO:0097067)2.19272422
126cellular potassium ion homeostasis (GO:0030007)2.18803654
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.17433868
128insulin-like growth factor receptor signaling pathway (GO:0048009)2.16831660
129establishment of endothelial barrier (GO:0061028)2.16635676
130positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.16162029
131positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.15301796
132cellular protein complex localization (GO:0034629)2.15265354
133adherens junction assembly (GO:0034333)2.15243522
134dendrite morphogenesis (GO:0048813)2.14399762
135gene silencing by RNA (GO:0031047)2.14260811
136regulation of Rac protein signal transduction (GO:0035020)2.13942957
137positive regulation of macrophage cytokine production (GO:0060907)2.13456309
138detection of bacterium (GO:0016045)2.12998305
139regulation of protein polyubiquitination (GO:1902914)2.12931694
140retrograde transport, vesicle recycling within Golgi (GO:0000301)2.12872491
141skin morphogenesis (GO:0043589)2.11288591
142positive regulation of gamma-delta T cell activation (GO:0046645)2.10695394
143positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.10687427
144pathway-restricted SMAD protein phosphorylation (GO:0060389)2.10391090
145stress granule assembly (GO:0034063)2.10327728
146regulation of histone H3-K9 methylation (GO:0051570)2.09805616
147histone lysine demethylation (GO:0070076)2.09618118
148positive regulation of Rap GTPase activity (GO:0032854)2.09492123
149negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.09141432
150negative regulation of translation, ncRNA-mediated (GO:0040033)2.09141432
151regulation of translation, ncRNA-mediated (GO:0045974)2.09141432
152mRNA transcription from RNA polymerase II promoter (GO:0042789)2.08545385
153regulation of gamma-delta T cell differentiation (GO:0045586)2.08429020
154positive regulation of mitotic sister chromatid separation (GO:1901970)2.07911211
155positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.07911211
156positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.07911211
157cellular response to growth hormone stimulus (GO:0071378)2.07710060
158exploration behavior (GO:0035640)2.07631868
159histone demethylation (GO:0016577)2.07534291
160iron ion import (GO:0097286)2.07251460
161necroptotic process (GO:0070266)2.07153283
162cortical actin cytoskeleton organization (GO:0030866)2.06523503
163regulation of Rap GTPase activity (GO:0032317)2.06219371
164positive regulation of fibroblast migration (GO:0010763)2.05552513
165positive regulation of dendritic spine morphogenesis (GO:0061003)2.05452182
166positive regulation of RNA splicing (GO:0033120)2.04446833
167mammary gland epithelial cell proliferation (GO:0033598)2.03999968
168regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.03124712
169sister chromatid segregation (GO:0000819)2.02676163
170positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.02385141
171response to interleukin-15 (GO:0070672)2.01323943
172cerebellar Purkinje cell differentiation (GO:0021702)2.01127477
173regulation of isotype switching to IgG isotypes (GO:0048302)2.00166925
174negative regulation of GTP catabolic process (GO:0033125)1.99361843
175negative regulation of GTPase activity (GO:0034260)1.99361843
176stress fiber assembly (GO:0043149)1.99083436
177regulation of T cell tolerance induction (GO:0002664)1.99060472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.41534774
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.19517932
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.85533395
4E2F7_22180533_ChIP-Seq_HELA_Human3.81748762
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.12636999
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.92148900
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.89536231
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79876724
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.78008510
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.69774930
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57816224
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.54340698
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50834752
14TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.47457349
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39969876
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.36518087
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.25053477
18MYC_22102868_ChIP-Seq_BL_Human2.20385992
19KDM2B_26808549_Chip-Seq_DND41_Human2.18882900
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.12541902
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.06547538
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.05928204
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03576381
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99585463
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.98969434
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94351360
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91373566
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85776772
29SALL4_18804426_ChIP-ChIP_XEN_Mouse1.84864695
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.83690680
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82798465
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82413248
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.81123100
34ZNF263_19887448_ChIP-Seq_K562_Human1.76306168
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.74646619
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.73993857
37GATA1_22025678_ChIP-Seq_K562_Human1.73658792
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70662070
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.69733294
40SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69402021
41SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69402021
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69018933
43* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.66286279
44TCF7_22412390_ChIP-Seq_EML_Mouse1.65550118
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63357500
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62433172
47* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59294785
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59056067
49* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.58620555
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.57992661
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56049705
52TP53_16413492_ChIP-PET_HCT116_Human1.52777716
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.50092609
54* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49230651
55RUNX_20019798_ChIP-Seq_JUKART_Human1.47952528
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.45008108
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43276280
58VDR_24787735_ChIP-Seq_THP-1_Human1.43102094
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41593999
60KDM2B_26808549_Chip-Seq_K562_Human1.40672956
61* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40381097
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38820625
63VDR_24763502_ChIP-Seq_THP-1_Human1.38083239
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36723976
65* PU_27001747_Chip-Seq_BMDM_Mouse1.36372197
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34848638
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33391999
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.31773774
69FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31494105
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31306333
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28294188
72ZNF274_21170338_ChIP-Seq_K562_Hela1.27863205
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25830022
74MYB_26560356_Chip-Seq_TH2_Human1.25450662
75GATA1_19941826_ChIP-Seq_K562_Human1.25063335
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24630447
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23584118
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23456397
79EZH2_22144423_ChIP-Seq_EOC_Human1.23232898
80SCL_19346495_ChIP-Seq_HPC-7_Human1.23154011
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.22634796
82AR_21572438_ChIP-Seq_LNCaP_Human1.20982977
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20847315
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.20723342
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20569023
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.16604205
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16370842
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16310098
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16019577
90UTX_26944678_Chip-Seq_JUKART_Human1.13457526
91* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13170870
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12711024
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12221165
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11497381
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.10842230
96VDR_21846776_ChIP-Seq_THP-1_Human1.09311849
97LXR_22158963_ChIP-Seq_LIVER_Mouse1.09236815
98* FOXA2_19822575_ChIP-Seq_HepG2_Human1.08406857
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08174612
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06591516
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06336970
102PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05908303
103MAF_26560356_Chip-Seq_TH1_Human1.05440375
104TRIM28_21343339_ChIP-Seq_HEK293_Human1.05113419
105DROSHA_22980978_ChIP-Seq_HELA_Human1.04975285
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.04559801
107* ELK3_25401928_ChIP-Seq_HUVEC_Human1.03271399
108RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03051949
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02422902
110* GATA3_27048872_Chip-Seq_THYMUS_Human1.02378190
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02330061
112AR_21909140_ChIP-Seq_LNCAP_Human1.01727009
113AHR_22903824_ChIP-Seq_MCF-7_Human1.01417279
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00629802
115* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98819310
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97793826
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.97597428
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.97597428
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97529740
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97253683
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97045166
122EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96942181
123BRD4_25478319_ChIP-Seq_HGPS_Human0.95870665
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95194595
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95179665
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94101291
127HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93963074
128EP300_21415370_ChIP-Seq_HL-1_Mouse0.93941802
129ARNT_22903824_ChIP-Seq_MCF-7_Human0.92989807
130MYB_26560356_Chip-Seq_TH1_Human0.92865134
131AR_19668381_ChIP-Seq_PC3_Human0.92048741
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91741359
133SPI1_23127762_ChIP-Seq_K562_Human0.91701299
134SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90615716
135TCF4_18268006_ChIP-ChIP_LS174T_Human0.90586773
136* STAT3_23295773_ChIP-Seq_U87_Human0.90267040
137SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89417719
138TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89339698
139CLOCK_20551151_ChIP-Seq_293T_Human0.89234609
140TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88649097
141KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88397826
142SOX2_21211035_ChIP-Seq_LN229_Gbm0.86252673
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85119000
144RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84947810
145RUNX1_27514584_Chip-Seq_MCF-7_Human0.83879641
146FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83717043
147POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.83646661
148* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82765811
149NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82165802
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82057360
151ISL1_27105846_Chip-Seq_CPCs_Mouse0.80786587
152SMAD4_21799915_ChIP-Seq_A2780_Human0.80331137
153OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78205984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.33832938
2MP0004859_abnormal_synaptic_plasticity3.32462592
3MP0010234_abnormal_vibrissa_follicle3.20885962
4MP0005076_abnormal_cell_differentiation3.12906232
5MP0003303_peritoneal_inflammation3.08792725
6MP0010352_gastrointestinal_tract_polyps3.01347818
7MP0003705_abnormal_hypodermis_morpholog2.92733264
8MP0000569_abnormal_digit_pigmentation2.58944269
9MP0002877_abnormal_melanocyte_morpholog2.48771434
10MP0003828_pulmonary_edema2.42134866
11MP0005451_abnormal_body_composition2.27009199
12MP0003453_abnormal_keratinocyte_physiol2.27003228
13MP0005409_darkened_coat_color2.26402197
14MP0009780_abnormal_chondrocyte_physiolo2.23024421
15MP0005623_abnormal_meninges_morphology2.06787721
16MP0003436_decreased_susceptibility_to1.96020831
17MP0004270_analgesia1.93776847
18MP0008438_abnormal_cutaneous_collagen1.93191058
19MP0003787_abnormal_imprinting1.92978685
20MP0003950_abnormal_plasma_membrane1.92430728
21MP0001835_abnormal_antigen_presentation1.83965534
22MP0010307_abnormal_tumor_latency1.81232124
23MP0003191_abnormal_cellular_cholesterol1.74773589
24MP0003635_abnormal_synaptic_transmissio1.73131542
25MP0003045_fibrosis1.69297659
26MP0003091_abnormal_cell_migration1.68929772
27MP0008260_abnormal_autophagy1.65397127
28MP0003656_abnormal_erythrocyte_physiolo1.59605222
29MP0002998_abnormal_bone_remodeling1.53696332
30MP0001851_eye_inflammation1.53066218
31MP0000685_abnormal_immune_system1.50262031
32MP0003123_paternal_imprinting1.49755009
33MP0001915_intracranial_hemorrhage1.48827177
34MP0005666_abnormal_adipose_tissue1.47837774
35MP0005023_abnormal_wound_healing1.46416756
36MP0004510_myositis1.43949564
37MP0005058_abnormal_lysosome_morphology1.41992512
38MP0001730_embryonic_growth_arrest1.40955952
39MP0002396_abnormal_hematopoietic_system1.39893618
40MP0002419_abnormal_innate_immunity1.39528471
41MP0003121_genomic_imprinting1.36430280
42MP0008961_abnormal_basal_metabolism1.36238274
43MP0004185_abnormal_adipocyte_glucose1.35055046
44MP0003880_abnormal_central_pattern1.31969966
45MP0002063_abnormal_learning/memory/cond1.31870289
46MP0003763_abnormal_thymus_physiology1.31807175
47MP0001299_abnormal_eye_distance/1.31052337
48MP0002084_abnormal_developmental_patter1.30954456
49MP0001348_abnormal_lacrimal_gland1.29804886
50MP0005000_abnormal_immune_tolerance1.28915155
51MP0003724_increased_susceptibility_to1.28733673
52MP0000858_altered_metastatic_potential1.27132011
53MP0004858_abnormal_nervous_system1.24743922
54MP0009840_abnormal_foam_cell1.24714973
55MP0003566_abnormal_cell_adhesion1.24413958
56MP0004811_abnormal_neuron_physiology1.23800883
57MP0000703_abnormal_thymus_morphology1.23229906
58MP0000350_abnormal_cell_proliferation1.22539915
59MP0002086_abnormal_extraembryonic_tissu1.22071527
60MP0004197_abnormal_fetal_growth/weight/1.22011257
61MP0000537_abnormal_urethra_morphology1.21784356
62MP0003941_abnormal_skin_development1.18400211
63MP0001790_abnormal_immune_system1.17528333
64MP0005387_immune_system_phenotype1.17528333
65MP0008770_decreased_survivor_rate1.17446580
66MP0003172_abnormal_lysosome_physiology1.15896087
67MP0005375_adipose_tissue_phenotype1.15038139
68MP0008004_abnormal_stomach_pH1.13266367
69MP0002909_abnormal_adrenal_gland1.12688090
70MP0002060_abnormal_skin_morphology1.12599052
71MP0000003_abnormal_adipose_tissue1.12592609
72MP0001853_heart_inflammation1.12239596
73MP0002405_respiratory_system_inflammati1.11849254
74MP0010678_abnormal_skin_adnexa1.11507612
75MP0003329_amyloid_beta_deposits1.11449084
76MP0003868_abnormal_feces_composition1.11255152
77MP0009278_abnormal_bone_marrow1.10144713
78MP0008877_abnormal_DNA_methylation1.10113957
79MP0000733_abnormal_muscle_development1.07769223
80MP0001800_abnormal_humoral_immune1.06246779
81MP0004233_abnormal_muscle_weight1.04332718
82MP0004264_abnormal_extraembryonic_tissu1.04280190
83MP0000778_abnormal_nervous_system1.03632715
84MP0005275_abnormal_skin_tensile1.02207810
85MP0002452_abnormal_antigen_presenting1.01963743
86MP0003221_abnormal_cardiomyocyte_apopto1.01947000
87MP0005310_abnormal_salivary_gland1.01766417
88MP0001697_abnormal_embryo_size1.01765667
89MP0003690_abnormal_glial_cell1.01017194
90MP0006082_CNS_inflammation0.99441745
91MP0002796_impaired_skin_barrier0.98760908
92MP0002064_seizures0.98357455
93MP0001849_ear_inflammation0.97885022
94MP0003183_abnormal_peptide_metabolism0.96457209
95MP0000767_abnormal_smooth_muscle0.95576560
96MP0005164_abnormal_response_to0.95176456
97MP0005025_abnormal_response_to0.94573687
98MP0002166_altered_tumor_susceptibility0.94181938
99MP0008057_abnormal_DNA_replication0.94112353
100MP0002138_abnormal_hepatobiliary_system0.93693080
101MP0002925_abnormal_cardiovascular_devel0.93227639
102MP0005464_abnormal_platelet_physiology0.93167907
103MP0003448_altered_tumor_morphology0.92194983
104MP0002088_abnormal_embryonic_growth/wei0.90956978
105MP0000955_abnormal_spinal_cord0.90680285
106MP0000013_abnormal_adipose_tissue0.90570686
107MP0003984_embryonic_growth_retardation0.90104229
108MP0009115_abnormal_fat_cell0.90008874
109MP0001533_abnormal_skeleton_physiology0.89716454
110MP0006054_spinal_hemorrhage0.89669603
111MP0002723_abnormal_immune_serum0.89589336
112MP0005397_hematopoietic_system_phenotyp0.89263530
113MP0001545_abnormal_hematopoietic_system0.89263530
114MP0004808_abnormal_hematopoietic_stem0.89199625
115MP0002085_abnormal_embryonic_tissue0.89109220
116MP0010155_abnormal_intestine_physiology0.89050542
117MP0002006_tumorigenesis0.88923178
118MP0003861_abnormal_nervous_system0.88205873
119MP0005187_abnormal_penis_morphology0.88189662
120MP0001216_abnormal_epidermal_layer0.87922431
121MP0002653_abnormal_ependyma_morphology0.87729304
122MP0002420_abnormal_adaptive_immunity0.87625402
123MP0001672_abnormal_embryogenesis/_devel0.87577546
124MP0005380_embryogenesis_phenotype0.87577546
125MP0009785_altered_susceptibility_to0.87311475
126MP0003122_maternal_imprinting0.86425134
127MP0001819_abnormal_immune_cell0.84932222
128MP0009745_abnormal_behavioral_response0.84719153
129MP0002734_abnormal_mechanical_nocicepti0.84517656
130MP0002080_prenatal_lethality0.83560985
131MP0000604_amyloidosis0.82572059
132MP0003075_altered_response_to0.82061402
133MP0002398_abnormal_bone_marrow0.81794944
134MP0009703_decreased_birth_body0.80928117
135MP0010630_abnormal_cardiac_muscle0.80907512
136MP0002184_abnormal_innervation0.80542716
137MP0003890_abnormal_embryonic-extraembry0.80211581
138MP0003111_abnormal_nucleus_morphology0.80182303
139MP0002152_abnormal_brain_morphology0.79318251
140MP0000920_abnormal_myelination0.78602435
141MP0002735_abnormal_chemical_nociception0.78295180
142MP0004947_skin_inflammation0.78199073
143MP0009046_muscle_twitch0.77291454
144MP0001784_abnormal_fluid_regulation0.76681706
145MP0003632_abnormal_nervous_system0.75881716
146MP0004957_abnormal_blastocyst_morpholog0.75486190
147MP0002896_abnormal_bone_mineralization0.73940279
148MP0009333_abnormal_splenocyte_physiolog0.73393931
149MP0000428_abnormal_craniofacial_morphol0.73228958
150MP0002733_abnormal_thermal_nociception0.73018307
151MP0002148_abnormal_hypersensitivity_rea0.72574465
152MP0001845_abnormal_inflammatory_respons0.72563259
153MP0005167_abnormal_blood-brain_barrier0.72416668
154MP0002139_abnormal_hepatobiliary_system0.72057944
155MP0003119_abnormal_digestive_system0.71302524
156MP0008569_lethality_at_weaning0.70336452
157MP0003077_abnormal_cell_cycle0.70011351
158MP0001968_abnormal_touch/_nociception0.69924954
159MP0002572_abnormal_emotion/affect_behav0.68603793
160MP0003283_abnormal_digestive_organ0.68386249
161MP0005621_abnormal_cell_physiology0.68317881
162MP0002009_preneoplasia0.67311775
163MP0003866_abnormal_defecation0.66315990
164MP0003634_abnormal_glial_cell0.65583994
165MP0005423_abnormal_somatic_nervous0.65522188
166MP0001440_abnormal_grooming_behavior0.65317944

Predicted human phenotypes

RankGene SetZ-score
1Termporal pattern (HP:0011008)3.19996308
2Insidious onset (HP:0003587)3.19996308
3Macroorchidism (HP:0000053)2.84822983
4Eczematoid dermatitis (HP:0000976)2.83397699
5Arterial tortuosity (HP:0005116)2.76897683
6Syringomyelia (HP:0003396)2.75315885
7Spinal cord lesions (HP:0100561)2.75315885
8Heterotopia (HP:0002282)2.70910594
9Amyotrophic lateral sclerosis (HP:0007354)2.66857030
10Urinary urgency (HP:0000012)2.61747994
11Osteolytic defects of the phalanges of the hand (HP:0009771)2.61184879
12Osteolytic defects of the hand bones (HP:0009699)2.61184879
13Subacute progressive viral hepatitis (HP:0006572)2.57401584
14Myocardial infarction (HP:0001658)2.56958517
15Abnormality of the common coagulation pathway (HP:0010990)2.48633715
16Vascular tortuosity (HP:0004948)2.42099445
17Flat acetabular roof (HP:0003180)2.41256505
18T lymphocytopenia (HP:0005403)2.38349840
19Deep palmar crease (HP:0006191)2.36972214
20Urinary bladder sphincter dysfunction (HP:0002839)2.36099449
21Protrusio acetabuli (HP:0003179)2.32721294
22Cerebral inclusion bodies (HP:0100314)2.28164357
23Visual hallucinations (HP:0002367)2.22691165
24Focal seizures (HP:0007359)2.22536979
25Volvulus (HP:0002580)2.21314116
26Ankyloglossia (HP:0010296)2.20478624
27Abnormality of macrophages (HP:0004311)2.19432869
28Papilledema (HP:0001085)2.18475981
29Inappropriate behavior (HP:0000719)2.18012905
30Abnormality of oral frenula (HP:0000190)2.17929095
31Abnormality of T cell number (HP:0011839)2.16682666
32Abnormality of the astrocytes (HP:0100707)2.15683022
33Astrocytoma (HP:0009592)2.15683022
34Gingivitis (HP:0000230)2.15411544
35Aqueductal stenosis (HP:0002410)2.15371790
36Impaired vibration sensation in the lower limbs (HP:0002166)2.14509358
37Spontaneous hematomas (HP:0007420)2.13525415
38Recurrent bacterial skin infections (HP:0005406)2.12842666
39Dysmetric saccades (HP:0000641)2.12418162
40Asymmetry of the thorax (HP:0001555)2.10847916
41Increased density of long bones (HP:0006392)2.10288373
42Deep philtrum (HP:0002002)2.09400608
43Impaired smooth pursuit (HP:0007772)2.09004154
44Disinhibition (HP:0000734)2.06706562
45Deep venous thrombosis (HP:0002625)2.05966860
46Gastrointestinal infarctions (HP:0005244)2.05880006
47Diplopia (HP:0000651)2.05167960
48Abnormality of binocular vision (HP:0011514)2.05167960
49Tetraparesis (HP:0002273)2.01403193
50Abnormality of the fingertips (HP:0001211)1.98060915
51Thoracolumbar scoliosis (HP:0002944)1.97818478
52Fatigue (HP:0012378)1.97261067
53Aortic aneurysm (HP:0004942)1.97113964
54Truncal ataxia (HP:0002078)1.96083432
55Insomnia (HP:0100785)1.94738150
56Apathy (HP:0000741)1.93777185
57Abnormality of the distal phalanx of the thumb (HP:0009617)1.93057150
58Acute myeloid leukemia (HP:0004808)1.92971484
59Recurrent gram-negative bacterial infections (HP:0005420)1.92683104
60Abnormality of the lower motor neuron (HP:0002366)1.91717556
61Esophageal varix (HP:0002040)1.90835743
62Abnormality of ocular smooth pursuit (HP:0000617)1.90800255
63Basal cell carcinoma (HP:0002671)1.90362077
64Overgrowth (HP:0001548)1.88331894
65Aneurysm (HP:0002617)1.86263715
66Abnormality of the corticospinal tract (HP:0002492)1.85864036
67Recurrent abscess formation (HP:0002722)1.85504771
68Persistence of primary teeth (HP:0006335)1.85338420
69Lower limb amyotrophy (HP:0007210)1.83851027
70Coarse hair (HP:0002208)1.83605231
71Action tremor (HP:0002345)1.83542114
72Neurofibrillary tangles (HP:0002185)1.83119370
73Scanning speech (HP:0002168)1.83095295
74Pointed chin (HP:0000307)1.82577500
75Genetic anticipation (HP:0003743)1.82469290
76Slow saccadic eye movements (HP:0000514)1.82410972
77Ependymoma (HP:0002888)1.82320325
78Cubitus valgus (HP:0002967)1.80405039
79Mediastinal lymphadenopathy (HP:0100721)1.80236202
80Cerebral aneurysm (HP:0004944)1.79975192
81Genu recurvatum (HP:0002816)1.79886271
82Drooling (HP:0002307)1.79477429
83Excessive salivation (HP:0003781)1.79477429
84Resting tremor (HP:0002322)1.78581092
85Pelvic girdle muscle weakness (HP:0003749)1.75998491
86Shallow orbits (HP:0000586)1.75613775
87Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74216075
88Transitional cell carcinoma of the bladder (HP:0006740)1.73961862
89Absent frontal sinuses (HP:0002688)1.73088646
90Bladder carcinoma (HP:0002862)1.73017155
91Bladder neoplasm (HP:0009725)1.73017155
92Diminished motivation (HP:0000745)1.72989909
93Peritonitis (HP:0002586)1.72333687
94Uterine leiomyosarcoma (HP:0002891)1.72088336
95Leiomyosarcoma (HP:0100243)1.72088336
96Thick nail (HP:0001805)1.71180189
97Oligodactyly (hands) (HP:0001180)1.70541369
98Truncal obesity (HP:0001956)1.70503623
99Conjunctival telangiectasia (HP:0000524)1.70467419
100Mitral valve prolapse (HP:0001634)1.70222532
101Curly hair (HP:0002212)1.70119660
102Periodontitis (HP:0000704)1.70064620
103Achilles tendon contracture (HP:0001771)1.69999467
104Cellulitis (HP:0100658)1.69970917
105Abnormality of the vasculature of the conjunctiva (HP:0008054)1.69224801
106Papillary thyroid carcinoma (HP:0002895)1.68988372
107Shoulder girdle muscle weakness (HP:0003547)1.68969735
108Abnormal foot bone ossification (HP:0010675)1.68963448
109Abnormality of the peritoneum (HP:0002585)1.68719135
110Segmental peripheral demyelination/remyelination (HP:0003481)1.68377230
111Spondylolisthesis (HP:0003302)1.67096458
112Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66986870
113Short 4th metacarpal (HP:0010044)1.66986870
114Dilatation of the ascending aorta (HP:0005111)1.65954867
115Narrow palate (HP:0000189)1.65725498
116Hyperacusis (HP:0010780)1.65558668
117Aortic dissection (HP:0002647)1.65039494
118Dislocated radial head (HP:0003083)1.63982572
119Vertebral compression fractures (HP:0002953)1.63674787
120Gastrointestinal carcinoma (HP:0002672)1.63416411
121Malignant gastrointestinal tract tumors (HP:0006749)1.63416411
122Spastic gait (HP:0002064)1.63302908
123Absent speech (HP:0001344)1.62533468
124Neonatal hypoglycemia (HP:0001998)1.60773978
125Viral hepatitis (HP:0006562)1.60352835
126Osteomyelitis (HP:0002754)1.60260469
127Fibrous tissue neoplasm (HP:0012316)1.59771460
128Decreased motor nerve conduction velocity (HP:0003431)1.59592583
129Gingival bleeding (HP:0000225)1.59545603
130Amyloidosis (HP:0011034)1.59479144
131Upper motor neuron abnormality (HP:0002127)1.59278739
132Right ventricular cardiomyopathy (HP:0011663)1.58557688
133Disproportionate tall stature (HP:0001519)1.58264886
134Biliary tract neoplasm (HP:0100574)1.58166626
135Obsessive-compulsive behavior (HP:0000722)1.58086795
136Vertebral arch anomaly (HP:0008438)1.57844726
137Buphthalmos (HP:0000557)1.57743044
138Broad thumb (HP:0011304)1.57462369
139Sandal gap (HP:0001852)1.56574725
140Deviation of the thumb (HP:0009603)1.56287876
141Polycythemia (HP:0001901)1.56278224
142Supranuclear gaze palsy (HP:0000605)1.55142528
143Thickened calvaria (HP:0002684)1.54789831
144Skull defect (HP:0001362)1.54474367
145Hand muscle atrophy (HP:0009130)1.54050764
146Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.53539062
147Neoplasm of the oral cavity (HP:0100649)1.53417845
148Focal motor seizures (HP:0011153)1.53377590
149Fibroma (HP:0010614)1.53011043
150Abnormality of the lumbar spine (HP:0100712)1.52988399
151Broad face (HP:0000283)1.52839315
152Missing ribs (HP:0000921)1.52385666
153Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.52370408
154Germ cell neoplasia (HP:0100728)1.52291645
155Renal cell carcinoma (HP:0005584)1.52262731
156Hypopigmentation of the fundus (HP:0007894)1.51938198
157Abnormality of the musculature of the pelvis (HP:0001469)1.51869859
158Abnormality of the hip-girdle musculature (HP:0001445)1.51869859
159Arnold-Chiari malformation (HP:0002308)1.51182784
160Prominent nose (HP:0000448)1.50883036
161Colitis (HP:0002583)1.50770118
162Distal lower limb amyotrophy (HP:0008944)1.50739171
163Wormian bones (HP:0002645)1.50108864
164Sacral dimple (HP:0000960)1.50024880
165Hammertoe (HP:0001765)1.49996348
166Intellectual disability, profound (HP:0002187)1.49876814
167Difficulty running (HP:0009046)1.49695419
168Relative macrocephaly (HP:0004482)1.49552872
169Facial hemangioma (HP:0000329)1.49388199
170Inflammation of the large intestine (HP:0002037)1.49156737
171Cortical dysplasia (HP:0002539)1.48841413
172Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.48687297
173Degeneration of the lateral corticospinal tracts (HP:0002314)1.48687297
174Open mouth (HP:0000194)1.48536932
175Testicular neoplasm (HP:0010788)1.48379558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.64778710
2MAP3K92.76946678
3CDK122.69768696
4PKN22.61652121
5PNCK2.33732242
6TRIB32.29186668
7SCYL22.26570763
8TYRO32.17481313
9MAP3K142.07515914
10NTRK32.05823239
11ALK2.04086264
12MAP2K32.01427508
13IRAK31.99428410
14EEF2K1.99392316
15PRKD31.89926631
16PDGFRA1.84569827
17SIK21.83794426
18KSR21.83491245
19STK241.78385621
20RET1.72112635
21MAP3K21.64227401
22BMPR21.62124845
23PDGFRB1.58187731
24MAP3K101.57350663
25MARK11.50214352
26PTK61.41651463
27CAMK1G1.40828463
28FGR1.40185870
29LATS11.39850088
30KSR11.37734321
31FGFR31.37059301
32AKT31.36650970
33TYK21.36559528
34CDC71.35727831
35PAK61.33163720
36MAP3K61.29993985
37BLK1.27766734
38SMG11.27588898
39NEK21.27493245
40RIPK11.25698219
41MAP3K11.25026678
42SGK21.21494616
43STK101.18117448
44NEK91.15406624
45MAP3K41.14013423
46BMX1.13973823
47NLK1.12092460
48SIK11.11580318
49CDK61.11391049
50TRPM71.08200291
51YES11.07893158
52EIF2AK31.07284148
53ICK1.06599727
54MAP3K31.03654814
55DMPK1.03329964
56MELK1.03130153
57EPHB11.00178722
58IRAK20.99161831
59TGFBR20.98575281
60MAP4K10.98312214
61GRK60.97843923
62PRKCH0.97576203
63TXK0.97361399
64WNK10.96816934
65IRAK40.95684180
66ITK0.95441029
67NTRK10.92375538
68IRAK10.90234460
69MARK30.90099893
70NTRK20.84813751
71JAK10.84802671
72BRD40.84563387
73FER0.83528969
74MINK10.83427111
75FGFR10.83382482
76JAK30.82805107
77ERN10.82760057
78MOS0.81908641
79TTN0.81890790
80PTK20.81737797
81MTOR0.80669174
82MAP3K130.80461447
83STK110.80447945
84RIPK40.79399972
85FES0.79250271
86TESK10.78675225
87HIPK20.78336425
88CSNK1D0.77840669
89FGFR40.76972917
90PDK10.76318764
91CAMKK10.76283920
92CDK50.75637667
93SIK30.75175762
94CSK0.74739817
95SGK2230.74279728
96SGK4940.74279728
97CAMK1D0.73843679
98PTK2B0.73504657
99TAOK20.72847703
100STK38L0.70233682
101MARK20.70031482
102MST1R0.69559387
103FGFR20.66543865
104SGK30.66161904
105PASK0.65731070
106EGFR0.64435976
107JAK20.64292641
108HCK0.63226691
109PDPK10.62816191
110CDC42BPA0.62634342
111PLK20.62493367
112INSR0.62083479
113CHEK10.61897708
114ZAP700.60480540
115MAPK100.60464629
116MAP3K80.58278834
117PAK30.58268704
118LCK0.58255199
119DDR20.57888809
120PAK40.57871567
121FYN0.57722641
122SGK10.57432932
123MAPK110.56459441
124EPHA30.56427693
125PRKAA20.55947235
126STK380.55764755
127BRAF0.55728517
128CSNK1G20.54858761
129MAP3K120.54459389
130STK30.54124531
131TAOK10.53428289
132CDK40.53220270
133CAMKK20.53214150
134IKBKE0.52990688
135LRRK20.51531487
136ATM0.50602576
137RAF10.50197084
138PRKDC0.49234936
139CDK140.49233574
140MAP3K50.49009667
141STK40.48173481
142MAP3K70.47414997
143CDK90.46939901
144PIK3CG0.46876171
145LATS20.46377794
146CDK20.46301807
147UHMK10.46046043
148CHUK0.42606685
149MET0.42595756

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91702973
2Long-term potentiation_Homo sapiens_hsa047201.87726865
3Leishmaniasis_Homo sapiens_hsa051401.69061335
4Dorso-ventral axis formation_Homo sapiens_hsa043201.66940018
5T cell receptor signaling pathway_Homo sapiens_hsa046601.65146554
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46016431
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44978469
8mTOR signaling pathway_Homo sapiens_hsa041501.39637449
9Glioma_Homo sapiens_hsa052141.38045902
10Renal cell carcinoma_Homo sapiens_hsa052111.37992112
11Type II diabetes mellitus_Homo sapiens_hsa049301.35157937
12Chronic myeloid leukemia_Homo sapiens_hsa052201.29889766
13Estrogen signaling pathway_Homo sapiens_hsa049151.29698689
14Staphylococcus aureus infection_Homo sapiens_hsa051501.29336316
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28103309
16Amphetamine addiction_Homo sapiens_hsa050311.28068338
17Dopaminergic synapse_Homo sapiens_hsa047281.28057838
18VEGF signaling pathway_Homo sapiens_hsa043701.27829702
19* Influenza A_Homo sapiens_hsa051641.25513067
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.21284804
21Amoebiasis_Homo sapiens_hsa051461.19070010
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18633645
23Colorectal cancer_Homo sapiens_hsa052101.18594293
24Measles_Homo sapiens_hsa051621.18523958
25Long-term depression_Homo sapiens_hsa047301.17791563
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.16405107
27Tuberculosis_Homo sapiens_hsa051521.15810961
28Adherens junction_Homo sapiens_hsa045201.14125533
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14046069
30Renin secretion_Homo sapiens_hsa049241.13581365
31ErbB signaling pathway_Homo sapiens_hsa040121.13331617
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12711566
33Inositol phosphate metabolism_Homo sapiens_hsa005621.11856064
34Pancreatic cancer_Homo sapiens_hsa052121.10424160
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10211603
36Oocyte meiosis_Homo sapiens_hsa041141.09476546
37Endometrial cancer_Homo sapiens_hsa052131.09001192
38Bladder cancer_Homo sapiens_hsa052191.08079335
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07645211
40FoxO signaling pathway_Homo sapiens_hsa040681.07537219
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06827992
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06185725
43MicroRNAs in cancer_Homo sapiens_hsa052061.06082261
44Non-small cell lung cancer_Homo sapiens_hsa052231.05636945
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.05511712
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04818059
47Cholinergic synapse_Homo sapiens_hsa047251.03965103
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03928407
49Hepatitis C_Homo sapiens_hsa051601.03843979
50Oxytocin signaling pathway_Homo sapiens_hsa049211.02698367
51Glutamatergic synapse_Homo sapiens_hsa047241.01902488
52Gap junction_Homo sapiens_hsa045401.00501975
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00118929
54Proteoglycans in cancer_Homo sapiens_hsa052051.00062688
55Circadian entrainment_Homo sapiens_hsa047131.00040657
56Gastric acid secretion_Homo sapiens_hsa049710.99860680
57Insulin secretion_Homo sapiens_hsa049110.99509674
58Malaria_Homo sapiens_hsa051440.98697430
59GnRH signaling pathway_Homo sapiens_hsa049120.98651338
60MAPK signaling pathway_Homo sapiens_hsa040100.97969227
61Viral myocarditis_Homo sapiens_hsa054160.96825305
62Salivary secretion_Homo sapiens_hsa049700.94285127
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94116582
64Endocytosis_Homo sapiens_hsa041440.94091789
65Alcoholism_Homo sapiens_hsa050340.93896773
66Other glycan degradation_Homo sapiens_hsa005110.93852399
67Axon guidance_Homo sapiens_hsa043600.93550931
68Synaptic vesicle cycle_Homo sapiens_hsa047210.93194895
69Osteoclast differentiation_Homo sapiens_hsa043800.93021188
70B cell receptor signaling pathway_Homo sapiens_hsa046620.92246213
71Prolactin signaling pathway_Homo sapiens_hsa049170.92057536
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91992620
73Chemokine signaling pathway_Homo sapiens_hsa040620.91462988
74Viral carcinogenesis_Homo sapiens_hsa052030.91382711
75Focal adhesion_Homo sapiens_hsa045100.90739493
76Prion diseases_Homo sapiens_hsa050200.89966827
77Morphine addiction_Homo sapiens_hsa050320.89416181
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.88973166
79mRNA surveillance pathway_Homo sapiens_hsa030150.88846432
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88614737
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.88217223
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86248262
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86205266
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86134226
85Prostate cancer_Homo sapiens_hsa052150.86100834
86Apoptosis_Homo sapiens_hsa042100.85188072
87HIF-1 signaling pathway_Homo sapiens_hsa040660.85124994
88Cocaine addiction_Homo sapiens_hsa050300.84604100
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84547387
90Legionellosis_Homo sapiens_hsa051340.84267616
91Herpes simplex infection_Homo sapiens_hsa051680.83966755
92Choline metabolism in cancer_Homo sapiens_hsa052310.83862264
93Insulin signaling pathway_Homo sapiens_hsa049100.83821554
94Nicotine addiction_Homo sapiens_hsa050330.82839917
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82785045
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.82250053
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81909841
98Complement and coagulation cascades_Homo sapiens_hsa046100.81585500
99Melanogenesis_Homo sapiens_hsa049160.80997925
100HTLV-I infection_Homo sapiens_hsa051660.80873102
101Fatty acid biosynthesis_Homo sapiens_hsa000610.80817905
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.80191428
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79800002
104Small cell lung cancer_Homo sapiens_hsa052220.79009125
105Allograft rejection_Homo sapiens_hsa053300.77777113
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.77637472
107Rap1 signaling pathway_Homo sapiens_hsa040150.77543633
108Insulin resistance_Homo sapiens_hsa049310.77443571
109Platelet activation_Homo sapiens_hsa046110.76972032
110Acute myeloid leukemia_Homo sapiens_hsa052210.75323110
111GABAergic synapse_Homo sapiens_hsa047270.75308368
112Toxoplasmosis_Homo sapiens_hsa051450.75094045
113Hepatitis B_Homo sapiens_hsa051610.74936357
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74888228
115Antigen processing and presentation_Homo sapiens_hsa046120.74854190
116Type I diabetes mellitus_Homo sapiens_hsa049400.74537087
117Olfactory transduction_Homo sapiens_hsa047400.74325620
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73667439
119Pertussis_Homo sapiens_hsa051330.73376587
120Tight junction_Homo sapiens_hsa045300.72947018
121Salmonella infection_Homo sapiens_hsa051320.72660247
122Shigellosis_Homo sapiens_hsa051310.71551413
123Thyroid cancer_Homo sapiens_hsa052160.71366404
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70738284
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68878297
126cAMP signaling pathway_Homo sapiens_hsa040240.68789946
127Wnt signaling pathway_Homo sapiens_hsa043100.68302540
128Hippo signaling pathway_Homo sapiens_hsa043900.68258820
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67492458
130TNF signaling pathway_Homo sapiens_hsa046680.65745270
131Autoimmune thyroid disease_Homo sapiens_hsa053200.65739431
132Systemic lupus erythematosus_Homo sapiens_hsa053220.64594882
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64353006
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64078021
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63680832
136African trypanosomiasis_Homo sapiens_hsa051430.63383622
137Notch signaling pathway_Homo sapiens_hsa043300.58320171
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56988050
139Pathways in cancer_Homo sapiens_hsa052000.56396941
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55035138
141Graft-versus-host disease_Homo sapiens_hsa053320.53809699
142Phagosome_Homo sapiens_hsa041450.49797368

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