AGFG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.09103088
2L-phenylalanine catabolic process (GO:0006559)6.09103088
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.86966606
4L-phenylalanine metabolic process (GO:0006558)5.86966606
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.64200807
6aromatic amino acid family catabolic process (GO:0009074)5.46850829
7alpha-linolenic acid metabolic process (GO:0036109)5.42203677
8bile acid biosynthetic process (GO:0006699)5.22799467
9cysteine metabolic process (GO:0006534)5.20836710
10urea metabolic process (GO:0019627)5.06544129
11urea cycle (GO:0000050)5.06544129
12intestinal cholesterol absorption (GO:0030299)5.01824400
13kynurenine metabolic process (GO:0070189)5.00249359
14sulfur amino acid catabolic process (GO:0000098)4.90713227
15indole-containing compound catabolic process (GO:0042436)4.84043957
16indolalkylamine catabolic process (GO:0046218)4.84043957
17tryptophan catabolic process (GO:0006569)4.84043957
18serine family amino acid catabolic process (GO:0009071)4.80697232
19high-density lipoprotein particle remodeling (GO:0034375)4.80543148
20glyoxylate metabolic process (GO:0046487)4.77721249
21negative regulation of fibrinolysis (GO:0051918)4.75173600
22nitrogen cycle metabolic process (GO:0071941)4.71577779
23complement activation, alternative pathway (GO:0006957)4.68240892
24lysine catabolic process (GO:0006554)4.58985096
25lysine metabolic process (GO:0006553)4.58985096
26dicarboxylic acid biosynthetic process (GO:0043650)4.56063693
27regulation of fibrinolysis (GO:0051917)4.51693119
28regulation of protein activation cascade (GO:2000257)4.48091684
29tryptophan metabolic process (GO:0006568)4.39853384
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.39643372
31negative regulation of sterol transport (GO:0032372)4.37424909
32negative regulation of cholesterol transport (GO:0032375)4.37424909
33regulation of apoptotic cell clearance (GO:2000425)4.31264696
34regulation of plasminogen activation (GO:0010755)4.29973646
35bile acid metabolic process (GO:0008206)4.27776769
36glycine metabolic process (GO:0006544)4.26329749
37peptidyl-glutamic acid carboxylation (GO:0017187)4.21918155
38protein carboxylation (GO:0018214)4.21918155
39glutamate metabolic process (GO:0006536)4.21525717
40reverse cholesterol transport (GO:0043691)4.21421549
41regulation of complement activation (GO:0030449)4.20743407
42amino-acid betaine metabolic process (GO:0006577)4.18212050
43cellular ketone body metabolic process (GO:0046950)4.09397291
44regulation of triglyceride catabolic process (GO:0010896)4.08976024
45plasma lipoprotein particle remodeling (GO:0034369)4.08516210
46protein-lipid complex remodeling (GO:0034368)4.08516210
47macromolecular complex remodeling (GO:0034367)4.08516210
48alpha-amino acid catabolic process (GO:1901606)4.02841245
49regulation of cholesterol biosynthetic process (GO:0045540)4.00708421
50serine family amino acid metabolic process (GO:0009069)4.00262978
51cellular modified amino acid catabolic process (GO:0042219)3.99198713
52regulation of humoral immune response (GO:0002920)3.92175560
53proline metabolic process (GO:0006560)3.91462773
54aromatic amino acid family metabolic process (GO:0009072)3.91404223
55regulation of bile acid biosynthetic process (GO:0070857)3.91155897
56intestinal absorption (GO:0050892)3.89938369
57homocysteine metabolic process (GO:0050667)3.89173418
58positive regulation of triglyceride lipase activity (GO:0061365)3.84963926
59positive regulation of lipoprotein lipase activity (GO:0051006)3.84963926
60positive regulation of steroid metabolic process (GO:0045940)3.84539245
61regulation of cholesterol esterification (GO:0010872)3.82776805
62plasma lipoprotein particle clearance (GO:0034381)3.80768412
63cellular amino acid catabolic process (GO:0009063)3.79154785
64regulation of cholesterol homeostasis (GO:2000188)3.75486656
65serine family amino acid biosynthetic process (GO:0009070)3.74939278
66plasma lipoprotein particle assembly (GO:0034377)3.74526321
67negative regulation of protein activation cascade (GO:2000258)3.74242504
68epoxygenase P450 pathway (GO:0019373)3.74162327
69phospholipid efflux (GO:0033700)3.73695146
70tyrosine metabolic process (GO:0006570)3.72167988
71regulation of cholesterol metabolic process (GO:0090181)3.67188183
72triglyceride homeostasis (GO:0070328)3.65697014
73acylglycerol homeostasis (GO:0055090)3.65697014
74positive regulation of lipid catabolic process (GO:0050996)3.65587365
75regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.65508528
76regulation of extracellular matrix disassembly (GO:0010715)3.64003251
77acute-phase response (GO:0006953)3.59372511
78cholesterol efflux (GO:0033344)3.58608267
79positive regulation of fatty acid biosynthetic process (GO:0045723)3.56330698
802-oxoglutarate metabolic process (GO:0006103)3.56020911
81coenzyme catabolic process (GO:0009109)3.55839372
82diacylglycerol metabolic process (GO:0046339)3.51979495
83cytolysis (GO:0019835)3.51269674
84acetyl-CoA metabolic process (GO:0006084)3.44496180
85negative regulation of blood coagulation (GO:0030195)3.43016854
86negative regulation of hemostasis (GO:1900047)3.43016854
87lipoprotein metabolic process (GO:0042157)3.42658428
88ketone body metabolic process (GO:1902224)3.41202591
89ethanol oxidation (GO:0006069)3.39144808
90sterol transport (GO:0015918)3.38976500
91cholesterol transport (GO:0030301)3.38976500
92positive regulation of extracellular matrix organization (GO:1903055)3.38644282
93positive regulation of fatty acid beta-oxidation (GO:0032000)3.35977551
94blood coagulation, intrinsic pathway (GO:0007597)3.35557221
95protein-lipid complex assembly (GO:0065005)3.34581633
96cholesterol homeostasis (GO:0042632)3.34187382
97regulation of fatty acid beta-oxidation (GO:0031998)3.33203322
98benzene-containing compound metabolic process (GO:0042537)3.32449066
99ethanol metabolic process (GO:0006067)3.31681447
100short-chain fatty acid metabolic process (GO:0046459)3.30500475
101arginine metabolic process (GO:0006525)3.29573576
102sterol homeostasis (GO:0055092)3.28518443
103regulation of extracellular matrix organization (GO:1903053)3.28183116
104fibrinolysis (GO:0042730)3.27789557
105bile acid and bile salt transport (GO:0015721)3.26676229
106plasma lipoprotein particle organization (GO:0071827)3.26452025
107organic acid catabolic process (GO:0016054)3.24592225
108carboxylic acid catabolic process (GO:0046395)3.24592225
109drug catabolic process (GO:0042737)3.20613731
110indolalkylamine metabolic process (GO:0006586)3.20235490
111acylglycerol catabolic process (GO:0046464)3.18496504
112neutral lipid catabolic process (GO:0046461)3.18496504
113positive regulation of triglyceride metabolic process (GO:0090208)3.18006701
114aspartate family amino acid catabolic process (GO:0009068)3.16353507
115imidazole-containing compound metabolic process (GO:0052803)3.16023902
116very-low-density lipoprotein particle assembly (GO:0034379)3.15442925
117phospholipid homeostasis (GO:0055091)3.14054430
118negative regulation of coagulation (GO:0050819)3.11267597
119negative regulation of complement activation (GO:0045916)3.11014133
120negative regulation of lipase activity (GO:0060192)3.10684156
121complement activation (GO:0006956)3.07582051
122cellular glucuronidation (GO:0052695)3.07053044
123disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.06803177
124killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.06803177
125complement activation, classical pathway (GO:0006958)3.06481236
126protein-lipid complex subunit organization (GO:0071825)3.06359903
127positive regulation of hemostasis (GO:1900048)3.06297048
128positive regulation of blood coagulation (GO:0030194)3.06297048
129proline biosynthetic process (GO:0006561)3.06189745
130cellular biogenic amine catabolic process (GO:0042402)3.05627138
131amine catabolic process (GO:0009310)3.05627138
132exogenous drug catabolic process (GO:0042738)3.02752071
133protein activation cascade (GO:0072376)3.02645494
134low-density lipoprotein particle remodeling (GO:0034374)3.00304319
135cofactor catabolic process (GO:0051187)2.99918747
136glutamine family amino acid biosynthetic process (GO:0009084)2.93567983
137negative regulation of wound healing (GO:0061045)2.92386801
138lipid homeostasis (GO:0055088)2.90514297
139negative regulation of lipid transport (GO:0032369)2.83588703
140regulation of fatty acid biosynthetic process (GO:0042304)2.81483338
141low-density lipoprotein particle clearance (GO:0034383)2.81070077
142flavonoid metabolic process (GO:0009812)2.80198696
143positive regulation of coagulation (GO:0050820)2.79069053
144embryonic retina morphogenesis in camera-type eye (GO:0060059)2.75674405
145renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.73355140
146glucuronate metabolic process (GO:0019585)2.68400739
147uronic acid metabolic process (GO:0006063)2.68400739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.57809440
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.51221144
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.64194879
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.02771883
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.92170658
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.39485261
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.09152303
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.27048023
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.15861747
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.53458578
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.30886829
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.26531783
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.05364968
14LXR_22292898_ChIP-Seq_THP-1_Human2.02540916
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.98711992
16ZNF263_19887448_ChIP-Seq_K562_Human1.96213098
17GATA1_22025678_ChIP-Seq_K562_Human1.95980479
18* RARB_27405468_Chip-Seq_BRAIN_Mouse1.82758026
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82532630
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80235341
21GATA1_19941827_ChIP-Seq_MEL_Mouse1.76748475
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76115188
23GATA1_19941826_ChIP-Seq_K562_Human1.69705516
24DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62075462
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.54371167
26* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.53068784
27TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52985742
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.52321956
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.51318405
30MYC_22102868_ChIP-Seq_BL_Human1.51071259
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50162635
32CLOCK_20551151_ChIP-Seq_293T_Human1.48427561
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.44103384
34KDM2B_26808549_Chip-Seq_DND41_Human1.42759299
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41784397
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39959544
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39899530
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38395195
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35115839
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34281427
41* GATA6_25053715_ChIP-Seq_YYC3_Human1.34078309
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33393310
43EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32880262
44E2F7_22180533_ChIP-Seq_HELA_Human1.32602597
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32362790
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32001883
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31932740
48* VDR_21846776_ChIP-Seq_THP-1_Human1.28881525
49TCF7_22412390_ChIP-Seq_EML_Mouse1.28454369
50GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27284435
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.25393203
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.20932830
53* FOXO3_23340844_ChIP-Seq_DLD1_Human1.20183798
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19878084
55GATA2_19941826_ChIP-Seq_K562_Human1.17845099
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15958602
57CREB1_26743006_Chip-Seq_LNCaP_Human1.15587406
58* GATA4_25053715_ChIP-Seq_YYC3_Human1.14528559
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.09400374
60* HNF4A_19822575_ChIP-Seq_HepG2_Human1.09064758
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07400941
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07248045
63KDM2B_26808549_Chip-Seq_K562_Human1.06502011
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.06158880
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04796539
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04756900
67RACK7_27058665_Chip-Seq_MCF-7_Human1.04469148
68GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.04125341
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04079168
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03854612
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01501295
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00519071
73EGR1_19374776_ChIP-ChIP_THP-1_Human0.99274263
74RARB_24833708_ChIP-Seq_LIVER_Mouse0.99227695
75RARA_24833708_ChIP-Seq_LIVER_Mouse0.98845237
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97970139
77CTCF_27219007_Chip-Seq_Bcells_Human0.97711838
78TP63_22573176_ChIP-Seq_HFKS_Human0.96715665
79ELK3_25401928_ChIP-Seq_HUVEC_Human0.96266084
80HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96138048
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96136411
82P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96128812
83* E2F1_20622854_ChIP-Seq_HELA_Human0.95591572
84RUNX1_27514584_Chip-Seq_MCF-7_Human0.95362786
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95118091
86JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95037526
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94879763
88MAF_26560356_Chip-Seq_TH1_Human0.94673798
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93623620
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92825167
91TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92652102
92TET1_21451524_ChIP-Seq_MESCs_Mouse0.92647009
93KDM2B_26808549_Chip-Seq_JURKAT_Human0.92504658
94ESR1_21235772_ChIP-Seq_MCF-7_Human0.92241433
95UTX_26944678_Chip-Seq_JUKART_Human0.92216564
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91565543
97* PHF8_20622854_ChIP-Seq_HELA_Human0.91244342
98CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90999230
99ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89586018
100* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89558093
101TRIM28_21343339_ChIP-Seq_HEK293_Human0.89548679
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88958788
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88913315
104ETS1_21867929_ChIP-Seq_TH2_Mouse0.88043666
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87888757
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86885998
107SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86885311
108* P68_20966046_ChIP-Seq_HELA_Human0.86846545
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86257172
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85885694
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.84708180
112REST_21632747_ChIP-Seq_MESCs_Mouse0.83148690
113RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80234730
114RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79858105
115* BCOR_27268052_Chip-Seq_Bcells_Human0.79837319
116* ELF1_20517297_ChIP-Seq_JURKAT_Human0.79611009
117BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79114126
118BRD4_27068464_Chip-Seq_AML-cells_Mouse0.78627530
119MYB_21317192_ChIP-Seq_ERMYB_Mouse0.77007215
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76889290
121* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76424763
122* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75985810
123SA1_27219007_Chip-Seq_Bcells_Human0.75901370
124DROSHA_22980978_ChIP-Seq_HELA_Human0.75743753
125* BCL6_27268052_Chip-Seq_Bcells_Human0.75377064
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.75366957
127* SMC4_20622854_ChIP-Seq_HELA_Human0.74785253
128* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.74641306
129SPI1_20517297_ChIP-Seq_HL60_Human0.73740220
130MAF_26560356_Chip-Seq_TH2_Human0.72608276
131MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.72271298
132SCL_19346495_ChIP-Seq_HPC-7_Human0.69691603
133* VDR_24763502_ChIP-Seq_THP-1_Human0.69077868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.99178626
2MP0005360_urolithiasis6.48758344
3MP0005085_abnormal_gallbladder_physiolo5.20689649
4MP0005365_abnormal_bile_salt4.91098174
5MP0008875_abnormal_xenobiotic_pharmacok4.00884777
6MP0010329_abnormal_lipoprotein_level3.25685835
7MP0004859_abnormal_synaptic_plasticity3.22270506
8MP0009840_abnormal_foam_cell3.03263170
9MP0003252_abnormal_bile_duct2.86317757
10MP0005083_abnormal_biliary_tract2.83513988
11MP0003656_abnormal_erythrocyte_physiolo2.67554517
12MP0005332_abnormal_amino_acid2.51639769
13MP0003191_abnormal_cellular_cholesterol2.43634214
14MP0010234_abnormal_vibrissa_follicle2.22354253
15MP0009780_abnormal_chondrocyte_physiolo2.18646721
16MP0002822_catalepsy2.05466877
17MP0003806_abnormal_nucleotide_metabolis2.03475082
18MP0000609_abnormal_liver_physiology2.02285575
19MP0010368_abnormal_lymphatic_system1.99980513
20MP0002118_abnormal_lipid_homeostasis1.83596905
21MP0001666_abnormal_nutrient_absorption1.82755761
22MP0003329_amyloid_beta_deposits1.80754260
23MP0003195_calcinosis1.77280372
24MP0000604_amyloidosis1.72522151
25MP0005319_abnormal_enzyme/_coenzyme1.65965475
26MP0005584_abnormal_enzyme/coenzyme_acti1.64733675
27MP0002138_abnormal_hepatobiliary_system1.60008773
28MP0002089_abnormal_postnatal_growth/wei1.57326279
29MP0003635_abnormal_synaptic_transmissio1.57148413
30MP0005409_darkened_coat_color1.57126790
31MP0003122_maternal_imprinting1.50872023
32MP0003183_abnormal_peptide_metabolism1.49500102
33MP0001968_abnormal_touch/_nociception1.48407748
34MP0004019_abnormal_vitamin_homeostasis1.47183139
35MP0002736_abnormal_nociception_after1.44726563
36MP0001661_extended_life_span1.42462939
37MP0008872_abnormal_physiological_respon1.41074369
38MP0000685_abnormal_immune_system1.38498271
39MP0005451_abnormal_body_composition1.37945012
40MP0001915_intracranial_hemorrhage1.33033163
41MP0005167_abnormal_blood-brain_barrier1.29299521
42MP0004130_abnormal_muscle_cell1.29027986
43MP0003075_altered_response_to1.25059705
44MP0009745_abnormal_behavioral_response1.24956373
45MP0003868_abnormal_feces_composition1.23978513
46MP0002735_abnormal_chemical_nociception1.23252133
47MP0002063_abnormal_learning/memory/cond1.22550602
48MP0008874_decreased_physiological_sensi1.20644208
49MP0003880_abnormal_central_pattern1.20188371
50MP0001764_abnormal_homeostasis1.18852850
51MP0000566_synostosis1.18695209
52MP0005535_abnormal_body_temperature1.17461437
53MP0009643_abnormal_urine_homeostasis1.15507977
54MP0002064_seizures1.14152667
55MP0005636_abnormal_mineral_homeostasis1.13807272
56MP0003123_paternal_imprinting1.13471403
57MP0001873_stomach_inflammation1.12472124
58MP0005464_abnormal_platelet_physiology1.11575503
59MP0000598_abnormal_liver_morphology1.09844010
60MP0005408_hypopigmentation1.09594280
61MP0001501_abnormal_sleep_pattern1.07972274
62MP0001348_abnormal_lacrimal_gland1.07528255
63MP0003705_abnormal_hypodermis_morpholog1.03336124
64MP0009333_abnormal_splenocyte_physiolog1.03218127
65MP0000003_abnormal_adipose_tissue1.01438342
66MP0003303_peritoneal_inflammation1.00884665
67MP0008961_abnormal_basal_metabolism0.99766702
68MP0003300_gastrointestinal_ulcer0.98838749
69MP0004147_increased_porphyrin_level0.96846288
70MP0003879_abnormal_hair_cell0.96702460
71MP0005166_decreased_susceptibility_to0.96407835
72MP0005058_abnormal_lysosome_morphology0.94309775
73MP0003436_decreased_susceptibility_to0.92868236
74MP0002909_abnormal_adrenal_gland0.90335928
75MP0001529_abnormal_vocalization0.90059259
76MP0003690_abnormal_glial_cell0.89760025
77MP0002837_dystrophic_cardiac_calcinosis0.89622130
78MP0006036_abnormal_mitochondrial_physio0.89393706
79MP0002572_abnormal_emotion/affect_behav0.84644511
80MP0004264_abnormal_extraembryonic_tissu0.84454145
81MP0009642_abnormal_blood_homeostasis0.83370373
82MP0002733_abnormal_thermal_nociception0.83340503
83MP0002876_abnormal_thyroid_physiology0.82948798
84MP0005334_abnormal_fat_pad0.82722190
85MP0003866_abnormal_defecation0.81474258
86MP0008469_abnormal_protein_level0.79829798
87MP0005076_abnormal_cell_differentiation0.79258158
88MP0009115_abnormal_fat_cell0.78469810
89MP0009763_increased_sensitivity_to0.77809882
90MP0002971_abnormal_brown_adipose0.76437041
91MP0005220_abnormal_exocrine_pancreas0.76371270
92MP0009765_abnormal_xenobiotic_induced0.76013039
93MP0002254_reproductive_system_inflammat0.75645458
94MP0003566_abnormal_cell_adhesion0.75459940
95MP0001756_abnormal_urination0.75276146
96MP0006035_abnormal_mitochondrial_morpho0.74852022
97MP0003953_abnormal_hormone_level0.74578678
98MP0001440_abnormal_grooming_behavior0.74006737
99MP0002078_abnormal_glucose_homeostasis0.73707699
100MP0009764_decreased_sensitivity_to0.73300254
101MP0004782_abnormal_surfactant_physiolog0.73021503
102MP0005647_abnormal_sex_gland0.72112103
103MP0002933_joint_inflammation0.72042732
104MP0010155_abnormal_intestine_physiology0.71872116
105MP0003186_abnormal_redox_activity0.69238766
106MP0005375_adipose_tissue_phenotype0.68980170
107MP0001765_abnormal_ion_homeostasis0.68278889
108MP0000920_abnormal_myelination0.68038312
109MP0005670_abnormal_white_adipose0.67836539
110MP0003633_abnormal_nervous_system0.67410980
111MP0000249_abnormal_blood_vessel0.67262191
112MP0004043_abnormal_pH_regulation0.67245404
113MP0002970_abnormal_white_adipose0.64882684
114MP0001790_abnormal_immune_system0.64181277
115MP0005387_immune_system_phenotype0.64181277
116MP0001944_abnormal_pancreas_morphology0.63937378
117MP0005023_abnormal_wound_healing0.61294469
118MP0005666_abnormal_adipose_tissue0.60379903
119MP0003950_abnormal_plasma_membrane0.60187330
120MP0002272_abnormal_nervous_system0.59894570
121MP0008569_lethality_at_weaning0.59238907
122MP0002132_abnormal_respiratory_system0.59204623
123MP0004185_abnormal_adipocyte_glucose0.59058031
124MP0005395_other_phenotype0.58914820
125MP0000639_abnormal_adrenal_gland0.58280206
126MP0005448_abnormal_energy_balance0.58176621
127MP0003172_abnormal_lysosome_physiology0.57981420
128MP0002166_altered_tumor_susceptibility0.57835336
129MP0002006_tumorigenesis0.57079761
130MP0002168_other_aberrant_phenotype0.56948711
131MP0002136_abnormal_kidney_physiology0.56487992
132MP0008873_increased_physiological_sensi0.55672459
133MP0005376_homeostasis/metabolism_phenot0.55513587
134MP0005379_endocrine/exocrine_gland_phen0.55202461
135MP0005025_abnormal_response_to0.54881702
136MP0002693_abnormal_pancreas_physiology0.54716134
137MP0005397_hematopoietic_system_phenotyp0.54556450
138MP0001545_abnormal_hematopoietic_system0.54556450
139MP0009046_muscle_twitch0.54171769
140MP0004924_abnormal_behavior0.53832151
141MP0005386_behavior/neurological_phenoty0.53832151
142MP0004270_analgesia0.53777250
143MP0001970_abnormal_pain_threshold0.53730183
144MP0004811_abnormal_neuron_physiology0.52227081
145MP0002067_abnormal_sensory_capabilities0.52200309
146MP0004858_abnormal_nervous_system0.52039789

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.21787013
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.77841890
3Xanthomatosis (HP:0000991)5.39652527
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.09754383
5Intrahepatic cholestasis (HP:0001406)4.72713378
6Prolonged partial thromboplastin time (HP:0003645)4.62404992
7Hyperlipoproteinemia (HP:0010980)4.53699950
8Hemorrhage of the eye (HP:0011885)4.51419833
9Complement deficiency (HP:0004431)4.42532438
10Hypobetalipoproteinemia (HP:0003563)4.37225483
11Hyperglycinemia (HP:0002154)4.06622416
12Hyperammonemia (HP:0001987)3.70087829
13Hyperglycinuria (HP:0003108)3.63112476
14Joint hemorrhage (HP:0005261)3.60717131
15Poikilocytosis (HP:0004447)3.57389896
16Abnormality of glycine metabolism (HP:0010895)3.55891745
17Abnormality of serine family amino acid metabolism (HP:0010894)3.55891745
18Ketosis (HP:0001946)3.54580660
19Abnormality of complement system (HP:0005339)3.53540493
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.45690920
21Epidermoid cyst (HP:0200040)3.44012057
22Acanthocytosis (HP:0001927)3.40719846
23Hypolipoproteinemia (HP:0010981)3.38033571
24Abnormality of pyrimidine metabolism (HP:0004353)3.29386101
25Hypoalphalipoproteinemia (HP:0003233)3.19362408
26Hyperbilirubinemia (HP:0002904)3.19324712
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.19111656
28Reticulocytosis (HP:0001923)3.15060065
29Abnormality of the common coagulation pathway (HP:0010990)3.08601929
30Myokymia (HP:0002411)3.07973882
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.07266181
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.05706058
33Vascular calcification (HP:0004934)3.00846773
34Abnormality of methionine metabolism (HP:0010901)2.99756840
35Neonatal onset (HP:0003623)2.87198784
36Cholelithiasis (HP:0001081)2.84610544
37Status epilepticus (HP:0002133)2.80319366
38Purpura (HP:0000979)2.79262989
39Gingival bleeding (HP:0000225)2.76750653
40Global brain atrophy (HP:0002283)2.75886068
41Flat acetabular roof (HP:0003180)2.75413770
42Hypercholesterolemia (HP:0003124)2.73197674
43Abnormality of the heme biosynthetic pathway (HP:0010472)2.70211625
44Nephritis (HP:0000123)2.69374512
45Abnormal gallbladder physiology (HP:0012438)2.69183900
46Cholecystitis (HP:0001082)2.69183900
47Gout (HP:0001997)2.66753174
48Abnormality of the lower motor neuron (HP:0002366)2.66546628
49Abnormality of nucleobase metabolism (HP:0010932)2.63691870
50Abnormality of carpal bone ossification (HP:0006257)2.63118167
51Delayed CNS myelination (HP:0002188)2.62657287
52Abnormality of serum amino acid levels (HP:0003112)2.62469131
53Hypochromic microcytic anemia (HP:0004840)2.61571624
54Abnormal gallbladder morphology (HP:0012437)2.60883458
55Cardiovascular calcification (HP:0011915)2.57338082
56Spontaneous abortion (HP:0005268)2.56529825
57Abnormality of fatty-acid metabolism (HP:0004359)2.53054942
58Pigmentary retinal degeneration (HP:0001146)2.52726895
59Fat malabsorption (HP:0002630)2.49514331
60Myocardial infarction (HP:0001658)2.48999581
61Recurrent gram-negative bacterial infections (HP:0005420)2.47942598
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.43547564
63Hypoglycemic coma (HP:0001325)2.43433618
64Abnormality of the Achilles tendon (HP:0005109)2.42164273
65Skin nodule (HP:0200036)2.41005922
66Mitral stenosis (HP:0001718)2.35947615
67Ketoacidosis (HP:0001993)2.33759787
68Abnormality of the intrinsic pathway (HP:0010989)2.33515696
69Abnormality of purine metabolism (HP:0004352)2.30844755
70Metabolic acidosis (HP:0001942)2.30039808
71Abnormal tarsal ossification (HP:0008369)2.28460912
72Irritability (HP:0000737)2.28221557
73Hepatocellular carcinoma (HP:0001402)2.27983175
74Mucopolysacchariduria (HP:0008155)2.23661037
75Urinary glycosaminoglycan excretion (HP:0003541)2.23661037
76Sensorimotor neuropathy (HP:0007141)2.16911385
77Asymmetry of the thorax (HP:0001555)2.11617290
78Amyloidosis (HP:0011034)2.11063131
79Impaired social interactions (HP:0000735)2.10773974
80Abnormal social behavior (HP:0012433)2.10773974
81Rickets (HP:0002748)2.10404496
82Thrombophlebitis (HP:0004418)2.09976751
83Abnormality of polysaccharide metabolism (HP:0011012)2.08894212
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08894212
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08894212
86Abnormal ossification of hand bones (HP:0005921)2.07041281
87Neonatal death (HP:0003811)2.06703617
88Systemic lupus erythematosus (HP:0002725)2.06552867
89Spastic diplegia (HP:0001264)2.06190039
90Abnormality of iron homeostasis (HP:0011031)2.05217796
91Lethargy (HP:0001254)2.04507250
92Hypophosphatemic rickets (HP:0004912)2.02749305
93Abnormality of the gallbladder (HP:0005264)2.02688062
94Cerebral inclusion bodies (HP:0100314)2.01483781
95Polycythemia (HP:0001901)1.98837456
96Focal motor seizures (HP:0011153)1.98549316
97Abnormal hand bone ossification (HP:0010660)1.98192330
98Pulmonary embolism (HP:0002204)1.97185984
99Joint swelling (HP:0001386)1.95516849
100Hyperventilation (HP:0002883)1.94761274
101Fair hair (HP:0002286)1.94226928
102Torticollis (HP:0000473)1.93722732
103Hypertriglyceridemia (HP:0002155)1.93093755
104Abnormality of transition element cation homeostasis (HP:0011030)1.92404465
105Glomerulonephritis (HP:0000099)1.91009854
106Visual hallucinations (HP:0002367)1.90952770
107Steatorrhea (HP:0002570)1.89726054
108Craniofacial dystonia (HP:0012179)1.88786463
109Vomiting (HP:0002013)1.87725283
110Increased serum ferritin (HP:0003281)1.87430064
111Conjugated hyperbilirubinemia (HP:0002908)1.86962157
112Increased mean platelet volume (HP:0011877)1.86915768
113Focal dystonia (HP:0004373)1.86470738
114Epistaxis (HP:0000421)1.86378652
115Abnormality of proline metabolism (HP:0010907)1.83766293
116Hydroxyprolinuria (HP:0003080)1.83766293
117Gastrointestinal infarctions (HP:0005244)1.83068553
118Poor eye contact (HP:0000817)1.83016632
119Menorrhagia (HP:0000132)1.82756905
120Dysmetric saccades (HP:0000641)1.82455957
121Limb hypertonia (HP:0002509)1.81933072
122Hypoplasia of the thymus (HP:0000778)1.81722656
123Focal seizures (HP:0007359)1.80632516
124Late onset (HP:0003584)1.80410327
125Achilles tendon contracture (HP:0001771)1.80124455
126Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78739989
127Dicarboxylic aciduria (HP:0003215)1.78739989
128Axonal loss (HP:0003447)1.78579512
129Abnormal platelet volume (HP:0011876)1.77583262
130Osteomalacia (HP:0002749)1.75837072
131Hypochromic anemia (HP:0001931)1.70995355
132Dysostosis multiplex (HP:0000943)1.70585375
133Potter facies (HP:0002009)1.69118234
134Facial shape deformation (HP:0011334)1.69118234
135Esophageal varix (HP:0002040)1.68732268
136Cerebral aneurysm (HP:0004944)1.67119284
137Widely patent fontanelles and sutures (HP:0004492)1.66565601
138Testicular neoplasm (HP:0010788)1.62468293
139Ileus (HP:0002595)1.60120869
140Hypotension (HP:0002615)1.59931850
141Lymphangioma (HP:0100764)1.58607234
142Vertebral compression fractures (HP:0002953)1.57874653
143Hypophosphatemia (HP:0002148)1.57714514
144Abnormal foot bone ossification (HP:0010675)1.55167229
145Bronchomalacia (HP:0002780)1.54710288
146Seborrheic dermatitis (HP:0001051)1.53846724
147Vaginal fistula (HP:0004320)1.52122963
148Generalized aminoaciduria (HP:0002909)1.51611920
149Flared iliac wings (HP:0002869)1.51014617
150Abnormality of the nasal septum (HP:0000419)1.49463559
151Prolonged bleeding time (HP:0003010)1.49268504
152Visceral angiomatosis (HP:0100761)1.48860446
153Abnormality of alkaline phosphatase activity (HP:0004379)1.47887022
154Small epiphyses (HP:0010585)1.46580653
155Abnormal platelet function (HP:0011869)1.45999249

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.97315711
2NTRK33.42344368
3ICK3.12544141
4TRIB33.11319075
5BCKDK3.02103920
6CDK122.90084457
7RIPK42.78746311
8PKN22.75333903
9DAPK22.66427110
10GRK62.58035789
11KSR22.46539392
12MAP3K92.46104753
13ERN12.32847143
14SMG12.30376379
15DAPK12.12020358
16FGFR42.07291004
17SIK12.06029121
18MINK12.04916686
19PRKD31.88495618
20MAP2K41.86503083
21KSR11.80806615
22SIK21.69163028
23NTRK11.59796347
24EPHA21.59712976
25CAMKK11.57257573
26FES1.51803094
27MAPK111.47471644
28FGFR21.45958013
29MAP4K11.44414344
30MAP3K101.42644852
31IRAK31.42268173
32MST1R1.31727627
33WNK41.29790291
34TAOK11.28570331
35NEK11.22434513
36PRKAA21.18828977
37PTK2B1.18701602
38MAPKAPK31.17446518
39RAF11.15313517
40PDK11.13909946
41BRSK11.13389564
42MAP3K41.12880205
43MAP3K131.12344490
44PAK61.10865521
45ARAF1.10347635
46WNK11.08046646
47RIPK11.06083474
48MARK21.04743877
49CDC42BPA1.04289153
50SGK31.03579547
51MAP3K121.02956762
52EEF2K1.02288825
53FGR0.99410124
54MAP2K30.99294152
55PDPK10.98920116
56TAOK30.98858903
57PIK3CA0.95048281
58PTK60.93388171
59RET0.93266564
60SYK0.93201789
61AKT30.93123930
62GRK50.93085181
63TNK20.92552048
64PRPF4B0.92537864
65MAP3K30.92420600
66STK380.91847180
67EPHB10.91746337
68JAK20.91671815
69MAP3K70.90171120
70PDGFRA0.88671029
71TYK20.87802596
72CAMK1D0.85694220
73CDK40.83121543
74PRKD20.82022961
75PRKCG0.80677086
76TAOK20.80600118
77NTRK20.80036380
78PRKG20.79448083
79KDR0.78856581
80ITK0.75674826
81MTOR0.75596658
82CDK50.73836906
83MAP2K60.73373773
84ABL20.73032344
85CSK0.72956313
86SIK30.66558195
87LMTK20.66163601
88IKBKE0.66155996
89FGFR10.65884270
90MAP3K110.65731082
91FLT30.64384333
92CDC70.63250957
93MAP2K70.62247938
94CDK180.62098240
95MAP2K10.60980573
96PRKCH0.60841869
97MELK0.60355393
98CDK150.60037642
99MAP3K10.60035200
100LATS20.59724613
101MAPK120.59642586
102MAP3K60.59007755
103DDR20.58148110
104HIPK20.57257855
105MET0.56642581
106MAP3K20.56581562
107TIE10.56362202
108FER0.56321577
109JAK10.55540811
110MAPK40.53913529
111CDK11A0.53842063
112SGK20.53436808
113PRKAA10.53383653
114PINK10.51999312
115BMX0.51903471
116SGK4940.50559448
117SGK2230.50559448
118CDK140.48152021
119PRKACG0.48094347
120FGFR30.46828671
121ZAP700.46190003
122PDK40.46022781
123PDK30.46022781
124BLK0.45514850
125SGK10.43881370
126PTK20.43778748
127NEK90.42555974
128CDK70.42389088
129TRPM70.40486355
130TYRO30.40355247
131CSF1R0.40243143
132STK110.39803284
133CDK90.39281542
134DYRK1B0.39092185
135PRKCZ0.38952987
136UHMK10.38688936
137CAMK10.38581963
138DAPK30.37865962
139LRRK20.37653959
140ERBB20.37428167
141TBK10.36962430
142FYN0.36754787
143PRKCQ0.36275983
144HCK0.36070392
145MAP3K80.35485605
146MAP3K140.34661168
147TGFBR20.34624154
148STK390.33741472
149IRAK40.33264278
150PRKCI0.32554643
151MAP2K20.32105151
152CAMK1G0.31177567
153SRC0.29852514
154MAPK30.28856225

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.63065968
2Nitrogen metabolism_Homo sapiens_hsa009104.13020837
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.68858886
4Arginine biosynthesis_Homo sapiens_hsa002203.29379602
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.97473046
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.90666982
7Complement and coagulation cascades_Homo sapiens_hsa046102.47847115
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39331913
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34733636
10Tryptophan metabolism_Homo sapiens_hsa003802.22852865
11Fatty acid degradation_Homo sapiens_hsa000712.20217864
12Butanoate metabolism_Homo sapiens_hsa006502.11672519
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09246476
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.03669659
15PPAR signaling pathway_Homo sapiens_hsa033201.97492516
16Other glycan degradation_Homo sapiens_hsa005111.95234526
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88541738
18Bile secretion_Homo sapiens_hsa049761.84538264
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.80278780
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80012668
21Fatty acid metabolism_Homo sapiens_hsa012121.74223198
22Peroxisome_Homo sapiens_hsa041461.72894761
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68276801
24Staphylococcus aureus infection_Homo sapiens_hsa051501.61756643
25Caffeine metabolism_Homo sapiens_hsa002321.61074062
26Propanoate metabolism_Homo sapiens_hsa006401.59609589
27beta-Alanine metabolism_Homo sapiens_hsa004101.53387132
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.48323130
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.47165311
30Vitamin B6 metabolism_Homo sapiens_hsa007501.44629594
31Pyruvate metabolism_Homo sapiens_hsa006201.43896735
32Biosynthesis of amino acids_Homo sapiens_hsa012301.39399399
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37624462
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36524947
35Phenylalanine metabolism_Homo sapiens_hsa003601.31791836
36Carbon metabolism_Homo sapiens_hsa012001.30042017
37Chemical carcinogenesis_Homo sapiens_hsa052041.24218033
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19291220
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.17748088
40Histidine metabolism_Homo sapiens_hsa003401.14129107
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.11267219
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06027846
43Selenocompound metabolism_Homo sapiens_hsa004501.03165951
44Glycerolipid metabolism_Homo sapiens_hsa005610.99682883
45Sulfur relay system_Homo sapiens_hsa041220.96543282
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95835690
47Folate biosynthesis_Homo sapiens_hsa007900.95300837
48ABC transporters_Homo sapiens_hsa020100.95241625
49Tyrosine metabolism_Homo sapiens_hsa003500.91134730
50Long-term potentiation_Homo sapiens_hsa047200.86861757
51Starch and sucrose metabolism_Homo sapiens_hsa005000.84737280
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.82543625
53Retinol metabolism_Homo sapiens_hsa008300.80692582
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75052332
55Fatty acid biosynthesis_Homo sapiens_hsa000610.74081447
56Pentose phosphate pathway_Homo sapiens_hsa000300.72711324
57Renin-angiotensin system_Homo sapiens_hsa046140.71879937
58Fat digestion and absorption_Homo sapiens_hsa049750.71216021
59Lysine degradation_Homo sapiens_hsa003100.70783838
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70584457
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69302838
62Galactose metabolism_Homo sapiens_hsa000520.64381448
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62114974
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61685135
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61679504
66Nicotine addiction_Homo sapiens_hsa050330.61592992
67Mineral absorption_Homo sapiens_hsa049780.60823150
68Thyroid hormone synthesis_Homo sapiens_hsa049180.60487784
69Amphetamine addiction_Homo sapiens_hsa050310.52662249
70Salivary secretion_Homo sapiens_hsa049700.49757758
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49753244
72Steroid biosynthesis_Homo sapiens_hsa001000.49736895
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49634800
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48008930
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44790440
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43442722
77N-Glycan biosynthesis_Homo sapiens_hsa005100.43246652
78Sphingolipid metabolism_Homo sapiens_hsa006000.43137738
79Inositol phosphate metabolism_Homo sapiens_hsa005620.42023407
80Fatty acid elongation_Homo sapiens_hsa000620.41394886
81Prion diseases_Homo sapiens_hsa050200.41280298
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.41272496
83Synaptic vesicle cycle_Homo sapiens_hsa047210.40844115
84Arginine and proline metabolism_Homo sapiens_hsa003300.40792801
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.39558607
86Glucagon signaling pathway_Homo sapiens_hsa049220.38664278
87Glutamatergic synapse_Homo sapiens_hsa047240.37236251
88Pertussis_Homo sapiens_hsa051330.37136377
89Insulin resistance_Homo sapiens_hsa049310.36841015
90Ovarian steroidogenesis_Homo sapiens_hsa049130.36530824
91Arachidonic acid metabolism_Homo sapiens_hsa005900.34805784
92Sulfur metabolism_Homo sapiens_hsa009200.34456344
93GABAergic synapse_Homo sapiens_hsa047270.34032392
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33530421
95Olfactory transduction_Homo sapiens_hsa047400.32893845
96Linoleic acid metabolism_Homo sapiens_hsa005910.32705320
97mTOR signaling pathway_Homo sapiens_hsa041500.31925154
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31668518
99Glioma_Homo sapiens_hsa052140.31302225
100Insulin signaling pathway_Homo sapiens_hsa049100.31129039
101Non-small cell lung cancer_Homo sapiens_hsa052230.30917320
102One carbon pool by folate_Homo sapiens_hsa006700.30893535
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30039427
104Circadian entrainment_Homo sapiens_hsa047130.27472181
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27315170
106Dopaminergic synapse_Homo sapiens_hsa047280.26542544
107Fructose and mannose metabolism_Homo sapiens_hsa000510.26521605
108Dorso-ventral axis formation_Homo sapiens_hsa043200.25203159
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24758170
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.23509763
111Metabolic pathways_Homo sapiens_hsa011000.21415007
112Vitamin digestion and absorption_Homo sapiens_hsa049770.21397517
113Renin secretion_Homo sapiens_hsa049240.21348930
114Type I diabetes mellitus_Homo sapiens_hsa049400.20499077
115Systemic lupus erythematosus_Homo sapiens_hsa053220.18573968
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18214226
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18086008
118VEGF signaling pathway_Homo sapiens_hsa043700.18066542
119AMPK signaling pathway_Homo sapiens_hsa041520.17931706
120Glutathione metabolism_Homo sapiens_hsa004800.17687583
121Bladder cancer_Homo sapiens_hsa052190.17646876
122GnRH signaling pathway_Homo sapiens_hsa049120.17597017
123Acute myeloid leukemia_Homo sapiens_hsa052210.17380558
124Hepatitis C_Homo sapiens_hsa051600.16836324
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16750313
126African trypanosomiasis_Homo sapiens_hsa051430.16341357
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16106772
128B cell receptor signaling pathway_Homo sapiens_hsa046620.15466053
129Choline metabolism in cancer_Homo sapiens_hsa052310.14967174
130Type II diabetes mellitus_Homo sapiens_hsa049300.13900986

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