AGGF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G8.26539292
2telomere maintenance via telomerase (GO:0007004)7.37090129
3protein localization to kinetochore (GO:0034501)6.26335755
4RNA-dependent DNA replication (GO:0006278)5.65419023
5protein localization to chromosome, centromeric region (GO:0071459)5.39692380
6production of molecular mediator involved in inflammatory response (GO:0002532)5.16446387
7nuclear pore organization (GO:0006999)5.08173520
8attachment of spindle microtubules to kinetochore (GO:0008608)5.03834312
9nuclear pore complex assembly (GO:0051292)4.85289792
10membrane budding (GO:0006900)4.62046781
11folic acid-containing compound biosynthetic process (GO:0009396)4.48457531
12regulation of translational termination (GO:0006449)4.44196180
13formation of translation preinitiation complex (GO:0001731)4.35213959
14regulation of spindle organization (GO:0090224)4.34146373
15DNA unwinding involved in DNA replication (GO:0006268)4.22694003
16mitotic metaphase plate congression (GO:0007080)4.19849447
17regulation of nuclear cell cycle DNA replication (GO:0033262)4.12829584
18protein localization to chromosome (GO:0034502)4.08482017
19negative regulation of histone methylation (GO:0031061)4.02161046
20regulation of RNA export from nucleus (GO:0046831)3.94003285
21mitotic nuclear envelope disassembly (GO:0007077)3.88949532
22replicative senescence (GO:0090399)3.82745232
23microtubule anchoring (GO:0034453)3.81936384
24spliceosomal tri-snRNP complex assembly (GO:0000244)3.78913405
25microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.78769511
26regulation of protein glycosylation (GO:0060049)3.78757730
27DNA topological change (GO:0006265)3.76328069
28nerve growth factor signaling pathway (GO:0038180)3.75116703
29nuclear envelope disassembly (GO:0051081)3.70468334
30membrane disassembly (GO:0030397)3.70468334
31ribosomal small subunit assembly (GO:0000028)3.69629440
32histone H2B ubiquitination (GO:0033523)3.69479284
33ribosome assembly (GO:0042255)3.67683269
34regulation of double-strand break repair via homologous recombination (GO:0010569)3.66624357
35maturation of 5.8S rRNA (GO:0000460)3.62464359
36regulation of mitotic spindle organization (GO:0060236)3.61528308
37localization within membrane (GO:0051668)3.60201926
38negative regulation of neurotransmitter secretion (GO:0046929)3.59038918
39regulation of mitotic spindle checkpoint (GO:1903504)3.57156093
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.57156093
41monoubiquitinated protein deubiquitination (GO:0035520)3.55485370
42metaphase plate congression (GO:0051310)3.46620849
43positive regulation of cell cycle checkpoint (GO:1901978)3.45092281
44mitotic sister chromatid cohesion (GO:0007064)3.43590145
45ribosome biogenesis (GO:0042254)3.43459553
46acrosome assembly (GO:0001675)3.41709900
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.38587588
48regulation of DNA endoreduplication (GO:0032875)3.37201307
49DNA strand elongation (GO:0022616)3.35946943
50intracellular estrogen receptor signaling pathway (GO:0030520)3.33498917
51regulation of cAMP-dependent protein kinase activity (GO:2000479)3.32742143
52pore complex assembly (GO:0046931)3.32295155
53interferon-gamma secretion (GO:0072643)3.31357605
54negative regulation of meiosis (GO:0045835)3.28005933
55IMP biosynthetic process (GO:0006188)3.27946992
56sister chromatid cohesion (GO:0007062)3.27699225
57telomere maintenance via telomere lengthening (GO:0010833)3.27543798
58DNA duplex unwinding (GO:0032508)3.26788765
59DNA geometric change (GO:0032392)3.26269882
60maturation of SSU-rRNA (GO:0030490)3.25686839
61COPII vesicle coating (GO:0048208)3.24324578
62microtubule severing (GO:0051013)3.23396804
63DNA replication checkpoint (GO:0000076)3.22834214
64pre-miRNA processing (GO:0031054)3.22599026
65nucleus organization (GO:0006997)3.21811317
66positive regulation of chromosome segregation (GO:0051984)3.21754050
67regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19487589
68positive regulation of glycoprotein biosynthetic process (GO:0010560)3.18930684
69spermatid nucleus differentiation (GO:0007289)3.16894393
70regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.16830180
71regulation of Golgi to plasma membrane protein transport (GO:0042996)3.14990659
72spliceosomal snRNP assembly (GO:0000387)3.14973949
73regulation of histone H3-K9 methylation (GO:0051570)3.12273402
74protein K48-linked ubiquitination (GO:0070936)3.11100473
75kinetochore organization (GO:0051383)3.10381006
76regulation of nucleobase-containing compound transport (GO:0032239)3.08159707
77clathrin coat assembly (GO:0048268)3.07270577
78regulation of helicase activity (GO:0051095)3.07262007
79protein targeting to Golgi (GO:0000042)3.06950270
80nuclear envelope organization (GO:0006998)3.06600042
81ribosomal large subunit biogenesis (GO:0042273)3.01537955
82histone H3-K9 demethylation (GO:0033169)3.01154979
83nucleobase biosynthetic process (GO:0046112)3.00680063
84positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00216486
85positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00216486
86positive regulation of mitotic sister chromatid separation (GO:1901970)3.00216486
87centrosome localization (GO:0051642)2.99968269
88heterochromatin organization (GO:0070828)2.99557058
89negative regulation of DNA recombination (GO:0045910)2.99527183
90regulation of histone H3-K27 methylation (GO:0061085)2.97968783
91pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.97636945
92DNA replication initiation (GO:0006270)2.97612727
93retrograde transport, vesicle recycling within Golgi (GO:0000301)2.96924946
94histone mRNA catabolic process (GO:0071044)2.96483600
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96305382
96response to UV-C (GO:0010225)2.95224672
97oogenesis (GO:0048477)2.92320617
98establishment of chromosome localization (GO:0051303)2.91785645
99resolution of meiotic recombination intermediates (GO:0000712)2.90806852
100cholesterol biosynthetic process (GO:0006695)2.90136362
101ribonucleoprotein complex biogenesis (GO:0022613)2.89456094
102kinetochore assembly (GO:0051382)2.88982380
103mitotic chromosome condensation (GO:0007076)2.87145018
104regulation of gene silencing by RNA (GO:0060966)2.86680195
105regulation of posttranscriptional gene silencing (GO:0060147)2.86680195
106regulation of gene silencing by miRNA (GO:0060964)2.86680195
107nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.85900630
108negative regulation of neurotransmitter transport (GO:0051589)2.83715037
109heart process (GO:0003015)2.83065625
110heart contraction (GO:0060047)2.83065625
111ncRNA 3-end processing (GO:0043628)2.82721919
112histone mRNA metabolic process (GO:0008334)2.82642226
113Golgi to endosome transport (GO:0006895)2.81393748
114purine nucleobase biosynthetic process (GO:0009113)2.80323781
115histone H2A monoubiquitination (GO:0035518)2.79767989
1163-UTR-mediated mRNA stabilization (GO:0070935)2.78865451
117intraciliary transport (GO:0042073)2.78266676
118DNA integration (GO:0015074)2.75799397
119sister chromatid segregation (GO:0000819)2.75087143
120embryonic body morphogenesis (GO:0010172)2.74972332
121establishment of protein localization to Golgi (GO:0072600)2.73372532
122pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.73289443
123DNA replication-dependent nucleosome organization (GO:0034723)2.73187271
124DNA replication-dependent nucleosome assembly (GO:0006335)2.73187271
125negative regulation of DNA-dependent DNA replication (GO:2000104)2.72643471
126pyrimidine nucleotide catabolic process (GO:0006244)2.72367700
127DNA conformation change (GO:0071103)2.71801371
128gene silencing by RNA (GO:0031047)2.71331874
129chromosome condensation (GO:0030261)2.69732514
130positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.69291546
131mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.69291546
132RNA stabilization (GO:0043489)2.68540167
133mRNA stabilization (GO:0048255)2.68540167
134DNA replication-independent nucleosome organization (GO:0034724)2.68030689
135DNA replication-independent nucleosome assembly (GO:0006336)2.68030689
136interleukin-6-mediated signaling pathway (GO:0070102)2.67950842
137peptidyl-lysine dimethylation (GO:0018027)2.67945947
138RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.66981968
139mRNA splicing, via spliceosome (GO:0000398)2.66981968
140RNA splicing, via transesterification reactions (GO:0000375)2.66824249
141chromatin assembly or disassembly (GO:0006333)2.65600242
142IMP metabolic process (GO:0046040)2.64360784
143folic acid metabolic process (GO:0046655)2.64230854
144regulation of meiosis I (GO:0060631)2.64229525
145regulation of sister chromatid cohesion (GO:0007063)2.63892273
146regulation of centrosome cycle (GO:0046605)2.63772238
147negative regulation of RNA splicing (GO:0033119)2.62750316
148rRNA processing (GO:0006364)2.62590279
149DNA strand elongation involved in DNA replication (GO:0006271)2.62396206
150synapsis (GO:0007129)2.61806792
151glucocorticoid receptor signaling pathway (GO:0042921)2.58955310
152histone monoubiquitination (GO:0010390)2.57492851
153sterol biosynthetic process (GO:0016126)2.57272132
154positive regulation of glycoprotein metabolic process (GO:1903020)2.54763502
155nucleotide-excision repair, DNA damage removal (GO:0000718)2.54644334
156DNA excision (GO:0044349)2.54644334
157peroxisome fission (GO:0016559)2.53398104
158magnesium ion transport (GO:0015693)2.52186693
159ribonucleoprotein complex disassembly (GO:0032988)2.50961558
160protein localization to Golgi apparatus (GO:0034067)2.49743176
161protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.49713077
162negative regulation of cell cycle G2/M phase transition (GO:1902750)2.48797426
163regulation of centrosome duplication (GO:0010824)2.48174098
164positive regulation of cell size (GO:0045793)2.47679291
165vesicle coating (GO:0006901)2.47592550
166centriole assembly (GO:0098534)2.47345218
167regulation of centriole replication (GO:0046599)2.46228333
168endoplasmic reticulum organization (GO:0007029)2.43638175
169protein localization to cilium (GO:0061512)2.41605601
170labyrinthine layer development (GO:0060711)2.40043038
171positive regulation of macroautophagy (GO:0016239)2.38831408
172regulation of translational initiation (GO:0006446)2.38803169
173regulation of mitotic metaphase/anaphase transition (GO:0030071)2.37929264
174regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.37929264
175ether lipid metabolic process (GO:0046485)2.36326124
176deoxyribose phosphate biosynthetic process (GO:0046385)2.35966549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.19938244
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.23016552
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.58142036
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.57570683
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.19091332
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02685224
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.95160961
8IGF1R_20145208_ChIP-Seq_DFB_Human2.93254486
9MYC_22102868_ChIP-Seq_BL_Human2.91502439
10* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.70670404
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69499646
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68704052
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.60167674
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.53178556
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39827135
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.36342650
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35422791
18ESR1_15608294_ChIP-ChIP_MCF-7_Human2.33027831
19AR_21909140_ChIP-Seq_LNCAP_Human2.30652910
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27652218
21TAF15_26573619_Chip-Seq_HEK293_Human2.26252845
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.15341765
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05369708
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04152203
25EWS_26573619_Chip-Seq_HEK293_Human2.02450835
26PADI4_21655091_ChIP-ChIP_MCF-7_Human2.02025715
27WT1_19549856_ChIP-ChIP_CCG9911_Human2.01796906
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90339690
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.89049212
30ZNF263_19887448_ChIP-Seq_K562_Human1.88443469
31FUS_26573619_Chip-Seq_HEK293_Human1.87011323
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84677869
33XRN2_22483619_ChIP-Seq_HELA_Human1.82093019
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79590796
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79394388
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73899596
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71091625
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.70010280
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67081569
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66965865
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64147958
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.61035335
43VDR_21846776_ChIP-Seq_THP-1_Human1.60524902
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58182409
45KDM5A_27292631_Chip-Seq_BREAST_Human1.56430066
46* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.49943011
47VDR_23849224_ChIP-Seq_CD4+_Human1.49482625
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49165875
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48617388
50* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48060304
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47169903
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44292156
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43586618
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42769658
55FOXP3_21729870_ChIP-Seq_TREG_Human1.42264905
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.41770242
57GBX2_23144817_ChIP-Seq_PC3_Human1.41131858
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40485288
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38421046
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37201333
61SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.36982031
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36875919
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35721277
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35238713
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35081934
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34554187
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34271709
68TCF7_22412390_ChIP-Seq_EML_Mouse1.34162746
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33827479
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33740414
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33740414
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.33313508
73SMAD4_21799915_ChIP-Seq_A2780_Human1.33042408
74KDM2B_26808549_Chip-Seq_DND41_Human1.32319503
75ER_23166858_ChIP-Seq_MCF-7_Human1.32187083
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.30285538
77SCL_19346495_ChIP-Seq_HPC-7_Human1.30060815
78* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29376891
79* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28782872
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28162061
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27726501
82E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27562914
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26993136
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.26952015
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.26512393
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.26424226
87TFEB_21752829_ChIP-Seq_HELA_Human1.25831390
88P300_19829295_ChIP-Seq_ESCs_Human1.25085479
89* GABP_19822575_ChIP-Seq_HepG2_Human1.24757382
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.23983014
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23512432
92TTF2_22483619_ChIP-Seq_HELA_Human1.22756349
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22315310
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21440713
95* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21436953
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20434947
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20383179
98CIITA_25753668_ChIP-Seq_RAJI_Human1.19931429
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.19357854
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19042747
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18154279
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17830277
103DCP1A_22483619_ChIP-Seq_HELA_Human1.16829920
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16579951
105* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.16509471
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.16413161
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14703057
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13245649
109STAT3_23295773_ChIP-Seq_U87_Human1.12577725
110CHD1_26751641_Chip-Seq_LNCaP_Human1.11992979
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11331379
112NCOR1_26117541_ChIP-Seq_K562_Human1.10715532
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10350224
114* ELF5_23300383_ChIP-Seq_T47D_Human1.09736688
115MAF_26560356_Chip-Seq_TH1_Human1.09621073
116ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09587918
117P53_22387025_ChIP-Seq_ESCs_Mouse1.09471293
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09085967
119REST_19997604_ChIP-ChIP_NEURONS_Mouse1.08681688
120IRF8_21731497_ChIP-ChIP_J774_Mouse1.07884678
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07802586
122YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07550864
123MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07446820
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07271055
125CBP_20019798_ChIP-Seq_JUKART_Human1.07222307
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07222307
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.07046681
128* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06005869
129ATF3_27146783_Chip-Seq_COLON_Human1.05856273
130* SPI1_23547873_ChIP-Seq_NB4_Human1.05818558
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04812491
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04747059
133MYB_26560356_Chip-Seq_TH1_Human1.04504538
134KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04186788
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04040262
136PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03000116
137TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01921815
138NANOG_21062744_ChIP-ChIP_HESCs_Human1.01469547
139UTX_26944678_Chip-Seq_JUKART_Human1.00740367
140SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00690093
141THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00287201
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99811065
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.99619202
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99447463
145CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98956892
146SALL1_21062744_ChIP-ChIP_HESCs_Human0.98883850
147TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98554727
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98343762
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.97451197
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.97327146
151NMYC_18555785_Chip-Seq_ESCs_Mouse0.97181025
152HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96678386
153FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96377850
154BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96303216
155ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96285959
156MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95336512
157SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93620037
158ELK1_19687146_ChIP-ChIP_HELA_Human0.93150780
159MYB_26560356_Chip-Seq_TH2_Human0.91113092
160TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89772087
161MAF_26560356_Chip-Seq_TH2_Human0.89695814
162STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89111268
163ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88888979
164SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88767760
165P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88243564
166RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88209209

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.50644130
2MP0003111_abnormal_nucleus_morphology4.15612502
3MP0003693_abnormal_embryo_hatching4.10230777
4MP0010094_abnormal_chromosome_stability3.67252145
5MP0003123_paternal_imprinting3.46909089
6MP0001529_abnormal_vocalization3.40314863
7MP0004957_abnormal_blastocyst_morpholog3.12659765
8MP0010352_gastrointestinal_tract_polyps3.09911139
9MP0003077_abnormal_cell_cycle2.89853233
10MP0004808_abnormal_hematopoietic_stem2.69157524
11MP0004233_abnormal_muscle_weight2.62141847
12MP0008057_abnormal_DNA_replication2.61596962
13MP0000490_abnormal_crypts_of2.57361935
14MP0009697_abnormal_copulation2.56723502
15MP0003705_abnormal_hypodermis_morpholog2.54423391
16MP0003787_abnormal_imprinting2.53535240
17MP0008789_abnormal_olfactory_epithelium2.48514741
18MP0010307_abnormal_tumor_latency2.42566397
19MP0000569_abnormal_digit_pigmentation2.41813568
20MP0001730_embryonic_growth_arrest2.28910859
21MP0005499_abnormal_olfactory_system2.27317940
22MP0005394_taste/olfaction_phenotype2.27317940
23MP0005076_abnormal_cell_differentiation2.24667198
24MP0008877_abnormal_DNA_methylation2.24365862
25MP0002396_abnormal_hematopoietic_system2.19484128
26MP0006054_spinal_hemorrhage2.18623299
27MP0008058_abnormal_DNA_repair2.04004346
28MP0003656_abnormal_erythrocyte_physiolo1.95951425
29MP0008007_abnormal_cellular_replicative1.93846812
30MP0002877_abnormal_melanocyte_morpholog1.91360759
31MP0000462_abnormal_digestive_system1.91269304
32MP0005397_hematopoietic_system_phenotyp1.87796801
33MP0001545_abnormal_hematopoietic_system1.87796801
34MP0000350_abnormal_cell_proliferation1.85342177
35MP0008260_abnormal_autophagy1.84669537
36MP0005248_abnormal_Harderian_gland1.83208746
37MP0010386_abnormal_urinary_bladder1.79760079
38MP0003221_abnormal_cardiomyocyte_apopto1.72838882
39MP0003303_peritoneal_inflammation1.66858945
40MP0002086_abnormal_extraembryonic_tissu1.64974798
41MP0010234_abnormal_vibrissa_follicle1.64478121
42MP0002006_tumorigenesis1.59615458
43MP0001835_abnormal_antigen_presentation1.58184551
44MP0003300_gastrointestinal_ulcer1.54731698
45MP0002233_abnormal_nose_morphology1.53875059
46MP0004197_abnormal_fetal_growth/weight/1.53780378
47MP0001672_abnormal_embryogenesis/_devel1.52002971
48MP0005380_embryogenesis_phenotype1.52002971
49MP0001697_abnormal_embryo_size1.50110510
50MP0006292_abnormal_olfactory_placode1.50033255
51MP0004185_abnormal_adipocyte_glucose1.49648401
52MP0001188_hyperpigmentation1.44334389
53MP0003984_embryonic_growth_retardation1.43480241
54MP0002080_prenatal_lethality1.43361623
55MP0006035_abnormal_mitochondrial_morpho1.42999188
56MP0002088_abnormal_embryonic_growth/wei1.42926457
57MP0000358_abnormal_cell_content/1.42731737
58MP0009333_abnormal_splenocyte_physiolog1.41248986
59MP0002398_abnormal_bone_marrow1.40646962
60MP0006276_abnormal_autonomic_nervous1.40410552
61MP0003567_abnormal_fetal_cardiomyocyte1.40006000
62MP0003122_maternal_imprinting1.39627308
63MP0003436_decreased_susceptibility_to1.38922139
64MP0000003_abnormal_adipose_tissue1.38321530
65MP0002084_abnormal_developmental_patter1.37645376
66MP0000703_abnormal_thymus_morphology1.35888696
67MP0000313_abnormal_cell_death1.35858935
68MP0003763_abnormal_thymus_physiology1.34993662
69MP0002019_abnormal_tumor_incidence1.34459528
70MP0002166_altered_tumor_susceptibility1.31421559
71MP0010155_abnormal_intestine_physiology1.28338119
72MP0005409_darkened_coat_color1.27528753
73MP0003183_abnormal_peptide_metabolism1.25922010
74MP0002822_catalepsy1.25034759
75MP0002722_abnormal_immune_system1.24873028
76MP0003121_genomic_imprinting1.23696419
77MP0001849_ear_inflammation1.23221777
78MP0001177_atelectasis1.19279724
79MP0009278_abnormal_bone_marrow1.17385088
80MP0002085_abnormal_embryonic_tissue1.15520192
81MP0003186_abnormal_redox_activity1.11861444
82MP0005386_behavior/neurological_phenoty1.11155514
83MP0004924_abnormal_behavior1.11155514
84MP0000778_abnormal_nervous_system1.10786972
85MP0000689_abnormal_spleen_morphology1.10447554
86MP0004947_skin_inflammation1.10075506
87MP0001800_abnormal_humoral_immune1.08177916
88MP0010678_abnormal_skin_adnexa1.08105310
89MP0000858_altered_metastatic_potential1.07704976
90MP0004270_analgesia1.07694110
91MP0000537_abnormal_urethra_morphology1.07361016
92MP0002452_abnormal_antigen_presenting1.04988848
93MP0003880_abnormal_central_pattern1.04813355
94MP0008932_abnormal_embryonic_tissue1.01211121
95MP0003566_abnormal_cell_adhesion1.00610072
96MP0002429_abnormal_blood_cell0.99891121
97MP0002160_abnormal_reproductive_system0.99698847
98MP0009672_abnormal_birth_weight0.99695133
99MP0000716_abnormal_immune_system0.99351762
100MP0001915_intracranial_hemorrhage0.97992666
101MP0005375_adipose_tissue_phenotype0.97307597
102MP0005187_abnormal_penis_morphology0.96475473
103MP0005621_abnormal_cell_physiology0.96077930
104MP0000685_abnormal_immune_system0.93108332
105MP0005646_abnormal_pituitary_gland0.92834762
106MP0003828_pulmonary_edema0.92774857
107MP0004142_abnormal_muscle_tone0.91473932
108MP0000477_abnormal_intestine_morphology0.91205743
109MP0001819_abnormal_immune_cell0.91103675
110MP0003385_abnormal_body_wall0.90626573
111MP0002420_abnormal_adaptive_immunity0.90194355
112MP0005379_endocrine/exocrine_gland_phen0.88626004
113MP0000427_abnormal_hair_cycle0.88194326
114MP0000598_abnormal_liver_morphology0.82823796
115MP0003786_premature_aging0.82752713
116MP0002723_abnormal_immune_serum0.82314396
117MP0005384_cellular_phenotype0.82284766
118MP0009703_decreased_birth_body0.81623452
119MP0001984_abnormal_olfaction0.80467307
120MP0005408_hypopigmentation0.80029612
121MP0005000_abnormal_immune_tolerance0.79822407
122MP0002092_abnormal_eye_morphology0.79541097
123MP0000013_abnormal_adipose_tissue0.79272379
124MP0003937_abnormal_limbs/digits/tail_de0.78075965
125MP0002163_abnormal_gland_morphology0.76899183
126MP0005025_abnormal_response_to0.76147395
127MP0001502_abnormal_circadian_rhythm0.76137507
128MP0003119_abnormal_digestive_system0.75754713
129MP0002090_abnormal_vision0.75712037
130MP0005220_abnormal_exocrine_pancreas0.75549513
131MP0000516_abnormal_urinary_system0.75153918
132MP0005367_renal/urinary_system_phenotyp0.75153918
133MP0002697_abnormal_eye_size0.74684157
134MP0004134_abnormal_chest_morphology0.74073570
135MP0002405_respiratory_system_inflammati0.73369563
136MP0001929_abnormal_gametogenesis0.73368726
137MP0005671_abnormal_response_to0.73209764
138MP0003252_abnormal_bile_duct0.72490990
139MP0001145_abnormal_male_reproductive0.72402329
140MP0001845_abnormal_inflammatory_respons0.72113152
141MP0001270_distended_abdomen0.71478397
142MP0005464_abnormal_platelet_physiology0.71137522
143MP0002127_abnormal_cardiovascular_syste0.70672910
144MP0001293_anophthalmia0.70630807
145MP0002095_abnormal_skin_pigmentation0.70360338
146MP0001851_eye_inflammation0.70181187
147MP0004811_abnormal_neuron_physiology0.69465954
148MP0002177_abnormal_outer_ear0.69448715
149MP0002419_abnormal_innate_immunity0.69265579
150MP0001186_pigmentation_phenotype0.68939627
151MP0000383_abnormal_hair_follicle0.68888755
152MP0002210_abnormal_sex_determination0.68775351
153MP0003868_abnormal_feces_composition0.68145212
154MP0001853_heart_inflammation0.67812221
155MP0005645_abnormal_hypothalamus_physiol0.67784043
156MP0003448_altered_tumor_morphology0.64608316
157MP0000653_abnormal_sex_gland0.64303559
158MP0008873_increased_physiological_sensi0.63251225
159MP0005666_abnormal_adipose_tissue0.60717536
160MP0003890_abnormal_embryonic-extraembry0.60444650
161MP0002653_abnormal_ependyma_morphology0.59840218

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)5.44081460
2Rough bone trabeculation (HP:0100670)4.78272589
3Birth length less than 3rd percentile (HP:0003561)4.34814535
4Degeneration of the lateral corticospinal tracts (HP:0002314)3.98357111
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.98357111
6Deep philtrum (HP:0002002)3.76299296
7Vertebral arch anomaly (HP:0008438)3.61957773
8Cutaneous melanoma (HP:0012056)3.61157881
9Termporal pattern (HP:0011008)3.46638309
10Insidious onset (HP:0003587)3.46638309
11Thyroid carcinoma (HP:0002890)3.40150465
12Abnormal trabecular bone morphology (HP:0100671)3.34114731
13Periodontitis (HP:0000704)3.27929271
14Abnormality of the corticospinal tract (HP:0002492)3.22243830
15Viral hepatitis (HP:0006562)3.15252036
16Premature graying of hair (HP:0002216)3.10054023
17Pheochromocytoma (HP:0002666)3.05163551
18Abnormal delayed hypersensitivity skin test (HP:0002963)2.99239750
19Abnormality of the musculature of the pelvis (HP:0001469)2.96513952
20Abnormality of the hip-girdle musculature (HP:0001445)2.96513952
21Impaired vibration sensation in the lower limbs (HP:0002166)2.96326288
22Panhypogammaglobulinemia (HP:0003139)2.94612350
23Degeneration of anterior horn cells (HP:0002398)2.94380512
24Abnormality of the anterior horn cell (HP:0006802)2.94380512
25Entropion (HP:0000621)2.91390436
26Recurrent viral infections (HP:0004429)2.89560861
27Biliary tract neoplasm (HP:0100574)2.88705505
28Freckling (HP:0001480)2.87009220
29Urinary urgency (HP:0000012)2.85609880
30Chronic mucocutaneous candidiasis (HP:0002728)2.84145528
31Recurrent cutaneous fungal infections (HP:0011370)2.84145528
32Ependymoma (HP:0002888)2.83870392
33Gastrointestinal carcinoma (HP:0002672)2.83469449
34Malignant gastrointestinal tract tumors (HP:0006749)2.83469449
35Rimmed vacuoles (HP:0003805)2.76783290
36Shoulder girdle muscle weakness (HP:0003547)2.74356633
37Neoplasm of the pancreas (HP:0002894)2.72731964
38Teleangiectasia of the skin (HP:0100585)2.71302306
39Colon cancer (HP:0003003)2.70081153
40Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.68018712
41Volvulus (HP:0002580)2.67751843
42Agnosia (HP:0010524)2.65642786
43Pulmonic stenosis (HP:0001642)2.63839425
44Agammaglobulinemia (HP:0004432)2.62112582
45Drooling (HP:0002307)2.59537023
46Basal cell carcinoma (HP:0002671)2.56012691
47Supernumerary spleens (HP:0009799)2.54167224
48Large earlobe (HP:0009748)2.53159969
49Pelvic girdle muscle weakness (HP:0003749)2.52851093
50Exercise-induced muscle cramps (HP:0003710)2.49678530
51* Cellulitis (HP:0100658)2.47351671
52Cellular immunodeficiency (HP:0005374)2.46820306
53Recurrent fungal infections (HP:0002841)2.45605701
54Melanoma (HP:0002861)2.44011424
55Poikiloderma (HP:0001029)2.43580059
56Sandal gap (HP:0001852)2.43432546
57Neuroendocrine neoplasm (HP:0100634)2.42196882
58Rectal prolapse (HP:0002035)2.38260550
59Myoglobinuria (HP:0002913)2.35791905
60Excessive salivation (HP:0003781)2.35128145
61Median cleft lip (HP:0000161)2.34851736
62Transitional cell carcinoma of the bladder (HP:0006740)2.33613959
63Leiomyosarcoma (HP:0100243)2.32824593
64Uterine leiomyosarcoma (HP:0002891)2.32824593
65Prominent nose (HP:0000448)2.31422198
66Congenital primary aphakia (HP:0007707)2.28661210
67Curly hair (HP:0002212)2.28538431
68Uterine neoplasm (HP:0010784)2.27908122
69Thrombocytosis (HP:0001894)2.27036260
70Gait imbalance (HP:0002141)2.25737194
71Microglossia (HP:0000171)2.24914802
72Urethral obstruction (HP:0000796)2.24854557
73Neoplasm of striated muscle (HP:0009728)2.24197996
74Gonadotropin excess (HP:0000837)2.23474117
75Spastic diplegia (HP:0001264)2.22902775
76Papilledema (HP:0001085)2.21732193
77Cortical dysplasia (HP:0002539)2.21250531
78Sensorimotor neuropathy (HP:0007141)2.21101447
79Capillary hemangiomas (HP:0005306)2.20845364
80Amaurosis fugax (HP:0100576)2.20693231
81Lymphoma (HP:0002665)2.20505700
82Generalized hyperpigmentation (HP:0007440)2.20363278
83Aseptic necrosis (HP:0010885)2.19297391
84Tubulointerstitial nephritis (HP:0001970)2.17931938
85Subacute progressive viral hepatitis (HP:0006572)2.13275766
86Selective tooth agenesis (HP:0001592)2.12923090
87Bladder neoplasm (HP:0009725)2.12476172
88Bladder carcinoma (HP:0002862)2.12476172
89Neonatal hypoglycemia (HP:0001998)2.11694914
90Rhabdomyosarcoma (HP:0002859)2.09964919
91Absent frontal sinuses (HP:0002688)2.09249449
92Neoplasm of the peripheral nervous system (HP:0100007)2.09203027
93Thyroid-stimulating hormone excess (HP:0002925)2.09045318
94Scanning speech (HP:0002168)2.08706103
95Overlapping toe (HP:0001845)2.08516617
96Missing ribs (HP:0000921)2.06737438
97Oral leukoplakia (HP:0002745)2.06598746
98Verrucae (HP:0200043)2.06520376
99Papilloma (HP:0012740)2.06520376
100Impulsivity (HP:0100710)2.06488286
101Abnormal pancreas size (HP:0012094)2.06037440
102Nephrogenic diabetes insipidus (HP:0009806)2.04793035
103Cystic hygroma (HP:0000476)2.04444723
104Abnormal biliary tract morphology (HP:0012440)2.03415716
105Atrophy/Degeneration involving motor neurons (HP:0007373)2.03254048
106Menstrual irregularities (HP:0000858)2.03174997
107Poor coordination (HP:0002370)2.02535926
108Hepatoblastoma (HP:0002884)2.00549182
109Asymmetry of the thorax (HP:0001555)2.00166936
110Abnormality of the fingertips (HP:0001211)1.99637984
111Abnormality of T cell physiology (HP:0011840)1.99207910
112Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98974000
113Acute myeloid leukemia (HP:0004808)1.97800006
114Medial flaring of the eyebrow (HP:0010747)1.97796349
115Glioma (HP:0009733)1.97597689
116Multiple enchondromatosis (HP:0005701)1.97389473
117Renal cortical cysts (HP:0000803)1.97285109
118Glucose intolerance (HP:0000833)1.96331807
119Neoplasm of the small intestine (HP:0100833)1.96236010
120Amyotrophic lateral sclerosis (HP:0007354)1.96138668
121Abnormality of the lower motor neuron (HP:0002366)1.95949141
122Global brain atrophy (HP:0002283)1.95910596
123Abnormality of T cells (HP:0002843)1.95736449
124Myelodysplasia (HP:0002863)1.94058503
125Nausea (HP:0002018)1.93567846
126Lower limb muscle weakness (HP:0007340)1.93492978
127Impaired vibratory sensation (HP:0002495)1.93327402
128Squamous cell carcinoma (HP:0002860)1.93260433
129Proximal placement of thumb (HP:0009623)1.91603367
13011 pairs of ribs (HP:0000878)1.90629223
131Increased serum pyruvate (HP:0003542)1.89660184
132Encephalitis (HP:0002383)1.89498461
133Short tibia (HP:0005736)1.88950098
134Hypermelanotic macule (HP:0001034)1.88318518
135Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87159235
136Abnormality of the astrocytes (HP:0100707)1.86962235
137Astrocytoma (HP:0009592)1.86962235
138Facial hemangioma (HP:0000329)1.85813093
139Polycythemia (HP:0001901)1.85233230
140Cutis marmorata (HP:0000965)1.84710123
141Bone marrow hypocellularity (HP:0005528)1.83401887
142Deviation of the thumb (HP:0009603)1.82966914
143Bundle branch block (HP:0011710)1.81761218
144Neoplasm of the rectum (HP:0100743)1.80736571
145Autoamputation (HP:0001218)1.80570043
146Spinal cord lesions (HP:0100561)1.79882929
147Syringomyelia (HP:0003396)1.79882929
148Long eyelashes (HP:0000527)1.79741069
149Neoplasm of the oral cavity (HP:0100649)1.79647086
150Neoplasm of the adrenal gland (HP:0100631)1.79254968
151Partial agenesis of the corpus callosum (HP:0001338)1.78148422
152Morphological abnormality of the pyramidal tract (HP:0002062)1.78107317
153Abnormality of the labia minora (HP:0012880)1.77688788
154Hematochezia (HP:0002573)1.77462207
155Rhabdomyolysis (HP:0003201)1.77230329
156Limb-girdle muscle atrophy (HP:0003797)1.77109705
157Tracheoesophageal fistula (HP:0002575)1.76409422
158Chromsome breakage (HP:0040012)1.75364328
159Microvesicular hepatic steatosis (HP:0001414)1.75304502
160Fatigue (HP:0012378)1.74894897
161Limb-girdle muscle weakness (HP:0003325)1.73836601
162Conjunctival telangiectasia (HP:0000524)1.73679179
163Carpal bone hypoplasia (HP:0001498)1.73250710
164Personality changes (HP:0000751)1.72594376
165Medulloblastoma (HP:0002885)1.72328124
166Blepharitis (HP:0000498)1.72097031
167Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.71285463
168Colitis (HP:0002583)1.71029171
169Adenoma sebaceum (HP:0009720)1.69261389
170Angiofibromas (HP:0010615)1.69261389
171Hypoglycemic coma (HP:0001325)1.68638862
172Exocrine pancreatic insufficiency (HP:0001738)1.68042532
173Increased nuchal translucency (HP:0010880)1.67206794
174Recurrent gram-negative bacterial infections (HP:0005420)1.65926254
175Abnormality of chromosome stability (HP:0003220)1.65675574
176Diastasis recti (HP:0001540)1.64897574
177Breast carcinoma (HP:0003002)1.62093523
178Abnormality of DNA repair (HP:0003254)1.60501758
179Low posterior hairline (HP:0002162)1.59639014
180Abnormality of the intervertebral disk (HP:0005108)1.59507036
181Cerebellar dysplasia (HP:0007033)1.58872755
182Abnormality of glycolysis (HP:0004366)1.57848286
183Wide nose (HP:0000445)1.57599372
184Hyperinsulinemic hypoglycemia (HP:0000825)1.56473583
185Heterotopia (HP:0002282)1.56129991
186Azoospermia (HP:0000027)1.54740986
187Paraplegia (HP:0010550)1.54447168
188Neoplasm of the adrenal cortex (HP:0100641)1.54315677
189Urinary bladder sphincter dysfunction (HP:0002839)1.54135335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.64030353
2CDK123.25325532
3NEK23.21794031
4ERBB33.13417372
5PBK2.95108563
6BCR2.66966828
7CDC72.58026344
8PKN22.20102284
9WEE12.18241334
10NEK92.03919359
11MAP3K121.98682796
12TRIB31.96131130
13STK38L1.95074121
14KSR21.95027847
15MAP3K101.93655901
16NME21.88674232
17MAP3K21.86168266
18SCYL21.83964669
19FGFR41.82915103
20JAK31.75764984
21ALK1.74430022
22RPS6KB21.67887574
23MAP4K11.65668520
24EEF2K1.65469668
25FGFR31.65107236
26BUB11.64630043
27CCNB11.62236411
28STK101.60485999
29BMPR21.57181157
30TTK1.53265439
31MAP3K91.50417507
32NEK61.48476636
33MAP3K131.48327424
34CSNK1G21.47185149
35PASK1.41286710
36CDK41.39742733
37NEK11.39646665
38STK241.37916214
39LATS11.34197499
40CSNK1A1L1.28673509
41CSNK1G31.26427646
42ARAF1.23541110
43PLK11.22211357
44AURKB1.20781644
45STK161.20637198
46ACVR1B1.20019915
47STK391.16544245
48PAK41.14171233
49CSNK1G11.13086652
50TYK21.11293253
51MAP2K71.10490631
52DAPK21.09318743
53WNK11.05119009
54ATR1.04880757
55BRSK21.04661046
56MUSK1.04082849
57MAP3K81.02141175
58MKNK11.02058819
59MKNK21.00022196
60TRIM280.99396443
61TSSK60.99088428
62TIE10.97095231
63RPS6KA40.95660186
64CDK60.95458055
65EIF2AK30.95152370
66LRRK20.94399672
67CHEK10.94017297
68PLK40.93628202
69PIM10.93238742
70DAPK10.90875100
71EPHA20.90239600
72FER0.89809714
73MAP3K40.89579764
74MAP2K40.88937527
75RPS6KB10.88172552
76DMPK0.87978520
77NTRK30.87875058
78EPHA30.87011666
79STK40.85639524
80EIF2AK10.85096062
81TGFBR10.83565910
82CDK20.82501994
83STK30.82351434
84MTOR0.82286748
85MAP3K10.80596045
86OBSCN0.79758596
87BMX0.79343531
88MARK30.79059911
89CHUK0.74514101
90SGK20.73521473
91GRK60.72649949
92CDK70.71147595
93PLK20.70882563
94LMTK20.70821801
95BRSK10.70744922
96TAOK20.70677133
97YES10.70367116
98LIMK10.68501317
99ATM0.67984167
100MET0.67716374
101NUAK10.67144129
102CDK90.66044512
103BRD40.65537941
104PLK30.65349029
105ZAP700.64296066
106PRKCH0.64295867
107CHEK20.64150921
108PIK3CA0.63857388
109MINK10.62974897
110ERBB40.62259563
111JAK20.61906316
112PAK60.61152828
113PDGFRB0.60235497
114CSNK2A20.59854352
115PTK60.59497277
116CDK80.59254320
117KIT0.58367958
118TAF10.57752471
119PRKACB0.57708617
120MOS0.57094327
121DYRK30.56941802
122SGK10.56110783
123RET0.54765663
124SRPK10.54545727
125TAOK10.53496772
126TAOK30.53448491
127LATS20.53409673
128PDGFRA0.53165943
129PAK30.51933666
130JAK10.51850775
131CASK0.50475395
132CDK140.49904921
133AURKA0.49523734
134MAP2K30.49013600
135BRAF0.47753761
136EPHA40.47165388
137CDK10.46922334
138MAPK110.46871511
139CSNK1E0.45651985
140TTN0.44805049
141CSNK1D0.43760808
142CAMK2A0.42999809
143PAK20.42087489
144MAP3K60.40894070
145EGFR0.39834267
146RIPK40.38961127
147MAPK130.38951006
148WNK40.38767658
149ABL20.37421898
150RPS6KA10.37221214
151FGFR10.33990430
152TYRO30.33029628
153KSR10.32368898
154MAP3K50.32180265
155PNCK0.31346019
156NLK0.30787756
157PRKDC0.30525140
158MAPK140.30232154
159RAF10.30108066
160MAPK100.28467720

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54859704
2RNA transport_Homo sapiens_hsa030133.14953903
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.12978258
4DNA replication_Homo sapiens_hsa030302.84433298
5Spliceosome_Homo sapiens_hsa030402.72953914
6Mismatch repair_Homo sapiens_hsa034302.70254250
7Steroid biosynthesis_Homo sapiens_hsa001002.65136984
8One carbon pool by folate_Homo sapiens_hsa006702.49505073
9Propanoate metabolism_Homo sapiens_hsa006402.14807837
10Cell cycle_Homo sapiens_hsa041102.14327424
11Protein export_Homo sapiens_hsa030602.13491131
12RNA polymerase_Homo sapiens_hsa030201.91720985
13Antigen processing and presentation_Homo sapiens_hsa046121.80106209
14mRNA surveillance pathway_Homo sapiens_hsa030151.79125101
15Long-term potentiation_Homo sapiens_hsa047201.77625442
16Circadian rhythm_Homo sapiens_hsa047101.61655205
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46803285
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44996826
19Selenocompound metabolism_Homo sapiens_hsa004501.43438452
20Herpes simplex infection_Homo sapiens_hsa051681.41459390
21RNA degradation_Homo sapiens_hsa030181.41007412
22mTOR signaling pathway_Homo sapiens_hsa041501.39896961
23Ribosome_Homo sapiens_hsa030101.38713706
24p53 signaling pathway_Homo sapiens_hsa041151.35097604
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29823047
26Pyrimidine metabolism_Homo sapiens_hsa002401.29685080
27Fatty acid elongation_Homo sapiens_hsa000621.28626314
28Base excision repair_Homo sapiens_hsa034101.28504624
29Peroxisome_Homo sapiens_hsa041461.27605478
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26981861
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25906710
32Apoptosis_Homo sapiens_hsa042101.23614141
33Chronic myeloid leukemia_Homo sapiens_hsa052201.22941219
34Thyroid cancer_Homo sapiens_hsa052161.22571743
35Leishmaniasis_Homo sapiens_hsa051401.21733559
36Small cell lung cancer_Homo sapiens_hsa052221.19346807
37Epstein-Barr virus infection_Homo sapiens_hsa051691.19048379
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18162015
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17433891
40Legionellosis_Homo sapiens_hsa051341.17037296
41Nucleotide excision repair_Homo sapiens_hsa034201.16967739
42Nitrogen metabolism_Homo sapiens_hsa009101.15027690
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14485641
44Non-small cell lung cancer_Homo sapiens_hsa052231.13520600
45Carbon metabolism_Homo sapiens_hsa012001.13215323
46Fatty acid metabolism_Homo sapiens_hsa012121.11981496
47MicroRNAs in cancer_Homo sapiens_hsa052061.11956043
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11618362
49Pentose phosphate pathway_Homo sapiens_hsa000301.08440320
50B cell receptor signaling pathway_Homo sapiens_hsa046621.06359226
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06310995
52HTLV-I infection_Homo sapiens_hsa051661.04671197
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03977492
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02455459
55Acute myeloid leukemia_Homo sapiens_hsa052211.02167785
56Viral carcinogenesis_Homo sapiens_hsa052031.00542555
57Colorectal cancer_Homo sapiens_hsa052100.98894407
58Measles_Homo sapiens_hsa051620.98479094
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98405928
60Pancreatic cancer_Homo sapiens_hsa052120.94771998
61Oocyte meiosis_Homo sapiens_hsa041140.92290231
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92205015
63FoxO signaling pathway_Homo sapiens_hsa040680.91422063
64Alcoholism_Homo sapiens_hsa050340.91313137
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.90477116
66Adherens junction_Homo sapiens_hsa045200.90415937
67Primary immunodeficiency_Homo sapiens_hsa053400.89623854
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89520980
69ErbB signaling pathway_Homo sapiens_hsa040120.89037619
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.89014462
71Osteoclast differentiation_Homo sapiens_hsa043800.88805746
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.88478259
73Fatty acid biosynthesis_Homo sapiens_hsa000610.87983727
74Basal transcription factors_Homo sapiens_hsa030220.87504801
75Influenza A_Homo sapiens_hsa051640.86941255
76Proteasome_Homo sapiens_hsa030500.86495880
77Homologous recombination_Homo sapiens_hsa034400.86292108
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84789645
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84112125
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.83082959
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83021303
82Endometrial cancer_Homo sapiens_hsa052130.82382680
83Hepatitis B_Homo sapiens_hsa051610.82344963
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.81757001
85HIF-1 signaling pathway_Homo sapiens_hsa040660.81450144
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81234289
87Butanoate metabolism_Homo sapiens_hsa006500.80678302
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80443589
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77264314
90AMPK signaling pathway_Homo sapiens_hsa041520.77220778
91Glioma_Homo sapiens_hsa052140.76652602
92Renin-angiotensin system_Homo sapiens_hsa046140.76588782
93Prolactin signaling pathway_Homo sapiens_hsa049170.74939108
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74503449
95Dopaminergic synapse_Homo sapiens_hsa047280.74393656
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73527624
97TNF signaling pathway_Homo sapiens_hsa046680.72687310
98Biosynthesis of amino acids_Homo sapiens_hsa012300.72611302
99Toxoplasmosis_Homo sapiens_hsa051450.72481201
100Insulin resistance_Homo sapiens_hsa049310.72040202
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.70506276
102Fanconi anemia pathway_Homo sapiens_hsa034600.70477411
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69519951
104Bladder cancer_Homo sapiens_hsa052190.68978831
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68935947
106Non-homologous end-joining_Homo sapiens_hsa034500.68534467
107VEGF signaling pathway_Homo sapiens_hsa043700.67552618
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67500644
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67463666
110Inositol phosphate metabolism_Homo sapiens_hsa005620.67229786
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64804528
112Tuberculosis_Homo sapiens_hsa051520.64708431
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.63159774
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62962960
115Folate biosynthesis_Homo sapiens_hsa007900.62906479
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.62646888
117T cell receptor signaling pathway_Homo sapiens_hsa046600.62429944
118TGF-beta signaling pathway_Homo sapiens_hsa043500.62017211
119Platelet activation_Homo sapiens_hsa046110.61935576
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61745288
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61619003
122Hippo signaling pathway_Homo sapiens_hsa043900.60971562
123beta-Alanine metabolism_Homo sapiens_hsa004100.60939724
124Choline metabolism in cancer_Homo sapiens_hsa052310.60246811
125Long-term depression_Homo sapiens_hsa047300.60098700
126GABAergic synapse_Homo sapiens_hsa047270.59299754
127Dorso-ventral axis formation_Homo sapiens_hsa043200.59130852
128Pyruvate metabolism_Homo sapiens_hsa006200.58955775
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58802683
130Proteoglycans in cancer_Homo sapiens_hsa052050.55664215
131Insulin signaling pathway_Homo sapiens_hsa049100.54210354
132Fructose and mannose metabolism_Homo sapiens_hsa000510.53928414
133Salmonella infection_Homo sapiens_hsa051320.53359731
134Amphetamine addiction_Homo sapiens_hsa050310.52908926
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52746180
136Prostate cancer_Homo sapiens_hsa052150.52588632
137Gap junction_Homo sapiens_hsa045400.50350044
138Renal cell carcinoma_Homo sapiens_hsa052110.48819390
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48733723
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47200407
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46794356
142Purine metabolism_Homo sapiens_hsa002300.45468027
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.45170862
144Systemic lupus erythematosus_Homo sapiens_hsa053220.45145524
145Type I diabetes mellitus_Homo sapiens_hsa049400.45141328
146Glucagon signaling pathway_Homo sapiens_hsa049220.44350372
147Regulation of autophagy_Homo sapiens_hsa041400.43596606
148Axon guidance_Homo sapiens_hsa043600.40960743
149Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39860019
150Fatty acid degradation_Homo sapiens_hsa000710.39530322
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36625355
152Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36194984
153N-Glycan biosynthesis_Homo sapiens_hsa005100.34998400

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »