ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	8.46261060
2	lung morphogenesis (GO:0060425)	5.57536293
3	heparin metabolic process (GO:0030202)	5.55724510
4	heparin biosynthetic process (GO:0030210)	5.55724510
5	platelet dense granule organization (GO:0060155)	5.17670386
6	proline transport (GO:0015824)	5.14815989
7	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	5.04806442
8	lung vasculature development (GO:0060426)	4.98673709
9	dopamine transport (GO:0015872)	4.81104292
10	piRNA metabolic process (GO:0034587)	4.73757271
11	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.64409871
12	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.64409871
13	regulation of translation, ncRNA-mediated (GO:0045974)	4.64409871
14	protein neddylation (GO:0045116)	4.56699944
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.53375558
16	retinal metabolic process (GO:0042574)	4.53287358
17	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	4.44011599
18	cellular ketone body metabolic process (GO:0046950)	4.41443391
19	positive regulation of mitochondrial fission (GO:0090141)	4.30508707
20	fusion of sperm to egg plasma membrane (GO:0007342)	3.99795537
21	NAD biosynthetic process (GO:0009435)	3.89888255
22	ketone body metabolic process (GO:1902224)	3.86855894
23	negative regulation of telomere maintenance (GO:0032205)	3.82561386
24	DNA methylation involved in gamete generation (GO:0043046)	3.75545928
25	fucose catabolic process (GO:0019317)	3.74092586
26	L-fucose metabolic process (GO:0042354)	3.74092586
27	L-fucose catabolic process (GO:0042355)	3.74092586
28	primary amino compound metabolic process (GO:1901160)	3.69739534
29	negative regulation of astrocyte differentiation (GO:0048712)	3.67792120
30	mitochondrial calcium ion transport (GO:0006851)	3.62434335
31	behavioral response to ethanol (GO:0048149)	3.56323765
32	behavioral response to nicotine (GO:0035095)	3.47033961
33	regulation of acrosome reaction (GO:0060046)	3.42580354
34	regulation of histone phosphorylation (GO:0033127)	3.41436376
35	organic cation transport (GO:0015695)	3.40738613
36	plasma membrane fusion (GO:0045026)	3.35099450
37	epithelial cilium movement (GO:0003351)	3.32503351
38	glucocorticoid receptor signaling pathway (GO:0042921)	3.32053711
39	cellular biogenic amine catabolic process (GO:0042402)	3.31944075
40	amine catabolic process (GO:0009310)	3.31944075
41	regulation of mitochondrial fission (GO:0090140)	3.31280425
42	somite development (GO:0061053)	3.30319314
43	adenosine metabolic process (GO:0046085)	3.24427502
44	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	3.22340595
45	detection of temperature stimulus involved in sensory perception (GO:0050961)	3.22340595
46	cilium or flagellum-dependent cell motility (GO:0001539)	3.20546387
47	lens fiber cell differentiation (GO:0070306)	3.19695747
48	endoderm formation (GO:0001706)	3.17986371
49	regulation of hippo signaling (GO:0035330)	3.11465666
50	serotonin metabolic process (GO:0042428)	3.10400010
51	tryptophan catabolic process (GO:0006569)	3.08720464
52	indole-containing compound catabolic process (GO:0042436)	3.08720464
53	indolalkylamine catabolic process (GO:0046218)	3.08720464
54	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.07088796
55	positive regulation of guanylate cyclase activity (GO:0031284)	3.03130819
56	kynurenine metabolic process (GO:0070189)	3.01899346
57	opioid receptor signaling pathway (GO:0038003)	2.99254268
58	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.98940311
59	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.95300275
60	pyridine nucleotide biosynthetic process (GO:0019363)	2.95300275
61	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.94085604
62	positive regulation of cAMP-mediated signaling (GO:0043950)	2.92196134
63	cilium movement (GO:0003341)	2.88513358
64	preassembly of GPI anchor in ER membrane (GO:0016254)	2.87584938
65	anterograde synaptic vesicle transport (GO:0048490)	2.87171386
66	phosphorelay signal transduction system (GO:0000160)	2.78913276
67	synaptic transmission, cholinergic (GO:0007271)	2.78486975
68	positive regulation of action potential (GO:0045760)	2.76671472
69	fatty acid transmembrane transport (GO:1902001)	2.71226499
70	positive regulation of CREB transcription factor activity (GO:0032793)	2.68908716
71	thrombin receptor signaling pathway (GO:0070493)	2.68384004
72	regulation of hexokinase activity (GO:1903299)	2.67423570
73	regulation of glucokinase activity (GO:0033131)	2.67423570
74	regulation of guanylate cyclase activity (GO:0031282)	2.65974420
75	cardiolipin metabolic process (GO:0032048)	2.65045110
76	multicellular organism reproduction (GO:0032504)	2.63669104
77	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.62876535
78	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.62876535
79	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.62859460
80	catecholamine transport (GO:0051937)	2.59516705
81	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.58461428
82	motile cilium assembly (GO:0044458)	2.56563678
83	retinoic acid metabolic process (GO:0042573)	2.56053120
84	neuronal action potential (GO:0019228)	2.54348284
85	regulation of female gonad development (GO:2000194)	2.52910755
86	protein polyglutamylation (GO:0018095)	2.52428715
87	cilium morphogenesis (GO:0060271)	2.52132896
88	corticosteroid receptor signaling pathway (GO:0031958)	2.51252298
89	photoreceptor cell maintenance (GO:0045494)	2.48705474
90	leukocyte migration involved in inflammatory response (GO:0002523)	2.47971373
91	histone H3-K9 methylation (GO:0051567)	2.47577500
92	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.47523644
93	sequestering of actin monomers (GO:0042989)	2.47250727
94	indole-containing compound metabolic process (GO:0042430)	2.45127109
95	detection of temperature stimulus (GO:0016048)	2.44898796
96	negative regulation of mast cell activation (GO:0033004)	2.44454652
97	rhodopsin mediated signaling pathway (GO:0016056)	2.44290239
98	axoneme assembly (GO:0035082)	2.43707898
99	response to acidic pH (GO:0010447)	2.43394492
100	male meiosis (GO:0007140)	2.43070235

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	6.57340166
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.57793480
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.23182507
4	TAF15_26573619_Chip-Seq_HEK293_Human	3.17535439
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.79576113
6	VDR_22108803_ChIP-Seq_LS180_Human	2.79223223
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.70362561
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.58383747
9	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.38175279
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.37250612
11	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.25533878
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.22739806
13	FUS_26573619_Chip-Seq_HEK293_Human	2.18997116
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.18679702
15	EWS_26573619_Chip-Seq_HEK293_Human	2.18321192
16	P300_19829295_ChIP-Seq_ESCs_Human	2.14514451
17	GATA1_22025678_ChIP-Seq_K562_Human	2.09094561
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.06117307
19	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.92615760
20	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.91230130
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.82951190
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.82663919
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.80505126
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.80059135
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.79916776
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72607244
27	AR_25329375_ChIP-Seq_VCAP_Human	1.65254103
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.60083765
29	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58748606
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.58748606
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.58055828
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57904210
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.54549696
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53962118
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.53143190
36	SOX2_19829295_ChIP-Seq_ESCs_Human	1.53143190
37	STAT3_23295773_ChIP-Seq_U87_Human	1.45194128
38	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.45113965
39	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.43143120
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43141892
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.42715232
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.41437560
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.39890788
44	TCF4_23295773_ChIP-Seq_U87_Human	1.39879211
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.39804376
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37568599
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34323006
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.31629310
49	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.28705668
50	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.26701679
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.25711602
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.25580606
53	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.22212497
54	AR_20517297_ChIP-Seq_VCAP_Human	1.21181950
55	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.19750327
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18456639
57	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.17244746
58	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16943677
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13086314
60	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12630818
61	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11870317
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11394891
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.11394891
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10583557
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10491965
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10491965
67	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.09655214
68	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08292246
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08137302
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07494879
71	TP53_16413492_ChIP-PET_HCT116_Human	1.06169507
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.05252257
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.04467283
74	REST_21632747_ChIP-Seq_MESCs_Mouse	1.03944779
75	RXR_22108803_ChIP-Seq_LS180_Human	1.03804379
76	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.03119657
77	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.02263242
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01358622
79	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00399822
80	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99750638
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98783062
82	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98127319
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97608015
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97054742
85	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.96504657
86	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.95499823
87	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.95499823
88	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.95009085
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.94497794
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.94456346
91	AR_21572438_ChIP-Seq_LNCaP_Human	0.94433061
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.93339390
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.92608946
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.92491392
95	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.92369815
96	MYC_18940864_ChIP-ChIP_HL60_Human	0.91878277
97	NCOR_22424771_ChIP-Seq_293T_Human	0.91719133
98	SCL_19346495_ChIP-Seq_HPC-7_Human	0.90611199
99	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.90362677
100	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.90101881

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.27868599
2	MP0002736_abnormal_nociception_after	3.98335448
3	MP0001968_abnormal_touch/_nociception	3.49805477
4	MP0005646_abnormal_pituitary_gland	3.38742342
5	MP0005464_abnormal_platelet_physiology	3.04869439
6	MP0002928_abnormal_bile_duct	2.73220223
7	MP0003195_calcinosis	2.72641031
8	MP0008875_abnormal_xenobiotic_pharmacok	2.31160514
9	MP0003646_muscle_fatigue	2.29401677
10	MP0008872_abnormal_physiological_respon	2.24251976
11	MP0002733_abnormal_thermal_nociception	2.13896110
12	MP0004147_increased_porphyrin_level	2.03506160
13	MP0003718_maternal_effect	1.92585179
14	MP0009745_abnormal_behavioral_response	1.92362567
15	MP0001986_abnormal_taste_sensitivity	1.84010333
16	MP0005645_abnormal_hypothalamus_physiol	1.83702155
17	MP0002102_abnormal_ear_morphology	1.81977422
18	MP0002160_abnormal_reproductive_system	1.81073230
19	MP0004130_abnormal_muscle_cell	1.80384385
20	MP0003119_abnormal_digestive_system	1.75130328
21	MP0004145_abnormal_muscle_electrophysio	1.71654824
22	MP0005551_abnormal_eye_electrophysiolog	1.71183403
23	MP0002132_abnormal_respiratory_system	1.70992670
24	MP0009379_abnormal_foot_pigmentation	1.66887960
25	MP0005389_reproductive_system_phenotype	1.61655476
26	MP0001764_abnormal_homeostasis	1.59101596
27	MP0001486_abnormal_startle_reflex	1.58040715
28	MP0004142_abnormal_muscle_tone	1.57721557
29	MP0004043_abnormal_pH_regulation	1.57281012
30	MP0003787_abnormal_imprinting	1.57107831
31	MP0006276_abnormal_autonomic_nervous	1.55279717
32	MP0009053_abnormal_anal_canal	1.50093408
33	MP0005167_abnormal_blood-brain_barrier	1.48812423
34	MP0009046_muscle_twitch	1.46687608
35	MP0009278_abnormal_bone_marrow	1.41951526
36	MP0000465_gastrointestinal_hemorrhage	1.37901183
37	MP0003943_abnormal_hepatobiliary_system	1.34977426
38	MP0002272_abnormal_nervous_system	1.34189370
39	MP0000230_abnormal_systemic_arterial	1.34158163
40	MP0000631_abnormal_neuroendocrine_gland	1.27755527
41	MP0002735_abnormal_chemical_nociception	1.27387665
42	MP0001970_abnormal_pain_threshold	1.26390199
43	MP0000678_abnormal_parathyroid_gland	1.25856812
44	MP0001664_abnormal_digestion	1.24026697
45	MP0004133_heterotaxia	1.23257860
46	MP0004215_abnormal_myocardial_fiber	1.23145779
47	MP0000372_irregular_coat_pigmentation	1.22474690
48	MP0003638_abnormal_response/metabolism_	1.20763863
49	MP0002064_seizures	1.18623825
50	MP0009697_abnormal_copulation	1.18548754
51	MP0000383_abnormal_hair_follicle	1.18370872
52	MP0002557_abnormal_social/conspecific_i	1.17219050
53	MP0006292_abnormal_olfactory_placode	1.16188839
54	MP0008004_abnormal_stomach_pH	1.16138822
55	MP0001919_abnormal_reproductive_system	1.14119945
56	MP0002653_abnormal_ependyma_morphology	1.11689915
57	MP0005410_abnormal_fertilization	1.11056895
58	MP0001545_abnormal_hematopoietic_system	1.10604787
59	MP0005397_hematopoietic_system_phenotyp	1.10604787
60	MP0010329_abnormal_lipoprotein_level	1.09929991
61	MP0003283_abnormal_digestive_organ	1.09883484
62	MP0001501_abnormal_sleep_pattern	1.09019895
63	MP0005085_abnormal_gallbladder_physiolo	1.08677951
64	MP0003252_abnormal_bile_duct	1.08083705
65	MP0008775_abnormal_heart_ventricle	1.06810147
66	MP0005084_abnormal_gallbladder_morpholo	1.05983837
67	MP0001663_abnormal_digestive_system	1.03878896
68	MP0003698_abnormal_male_reproductive	1.03761462
69	MP0003880_abnormal_central_pattern	1.03398845
70	MP0005174_abnormal_tail_pigmentation	1.01718950
71	MP0003828_pulmonary_edema	0.99908159
72	MP0005332_abnormal_amino_acid	0.99809566
73	MP0000015_abnormal_ear_pigmentation	0.93386811
74	MP0003137_abnormal_impulse_conducting	0.91643984
75	MP0002734_abnormal_mechanical_nocicepti	0.91585891
76	MP0005195_abnormal_posterior_eye	0.89765921
77	MP0003122_maternal_imprinting	0.88996184
78	MP0001293_anophthalmia	0.87542032
79	MP0000467_abnormal_esophagus_morphology	0.86205493
80	MP0003942_abnormal_urinary_system	0.83161405
81	MP0002572_abnormal_emotion/affect_behav	0.82207432
82	MP0002063_abnormal_learning/memory/cond	0.80904626
83	MP0005448_abnormal_energy_balance	0.80827954
84	MP0002095_abnormal_skin_pigmentation	0.80122010
85	MP0000653_abnormal_sex_gland	0.79861993
86	MP0004085_abnormal_heartbeat	0.79700265
87	MP0006036_abnormal_mitochondrial_physio	0.79346915
88	MP0005381_digestive/alimentary_phenotyp	0.78647147
89	MP0002876_abnormal_thyroid_physiology	0.77571112
90	MP0003635_abnormal_synaptic_transmissio	0.76649084
91	MP0003186_abnormal_redox_activity	0.75849432
92	MP0000778_abnormal_nervous_system	0.73091385
93	MP0002067_abnormal_sensory_capabilities	0.72439411
94	MP0000049_abnormal_middle_ear	0.71064029
95	MP0002210_abnormal_sex_determination	0.70353904
96	MP0009764_decreased_sensitivity_to	0.69826943
97	MP0002837_dystrophic_cardiac_calcinosis	0.69155048
98	MP0002282_abnormal_trachea_morphology	0.67631507
99	MP0005187_abnormal_penis_morphology	0.67415563
100	MP0001905_abnormal_dopamine_level	0.64656958

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	5.06551136
2	Type II lissencephaly (HP:0007260)	4.78966281
3	Pancreatic fibrosis (HP:0100732)	4.74139753
4	True hermaphroditism (HP:0010459)	4.09089898
5	Bile duct proliferation (HP:0001408)	4.04868947
6	Abnormal biliary tract physiology (HP:0012439)	4.04868947
7	Absent/shortened dynein arms (HP:0200106)	3.79022045
8	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.79022045
9	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.72189454
10	Abnormality of alanine metabolism (HP:0010916)	3.72189454
11	Hyperalaninemia (HP:0003348)	3.72189454
12	Cystic liver disease (HP:0006706)	3.69592998
13	Prolonged bleeding time (HP:0003010)	3.38216709
14	Abnormality of the renal cortex (HP:0011035)	3.35909389
15	Abnormality of midbrain morphology (HP:0002418)	3.35426433
16	Molar tooth sign on MRI (HP:0002419)	3.35426433
17	Renal cortical cysts (HP:0000803)	3.26394648
18	Clumsiness (HP:0002312)	3.25204920
19	Nephronophthisis (HP:0000090)	3.21134401
20	Partial agenesis of the corpus callosum (HP:0001338)	3.00208403
21	Enlarged kidneys (HP:0000105)	2.96767255
22	Lissencephaly (HP:0001339)	2.96345410
23	Abnormality of the renal medulla (HP:0100957)	2.89626819
24	Febrile seizures (HP:0002373)	2.86662379
25	Increased mean platelet volume (HP:0011877)	2.82512557
26	Asplenia (HP:0001746)	2.80694777
27	Furrowed tongue (HP:0000221)	2.77170236
28	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.66619515
29	Generalized aminoaciduria (HP:0002909)	2.61179227
30	Abnormal respiratory epithelium morphology (HP:0012253)	2.60747547
31	Abnormal respiratory motile cilium morphology (HP:0005938)	2.60747547
32	Menorrhagia (HP:0000132)	2.60398033
33	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.56313262
34	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.53706839
35	Petechiae (HP:0000967)	2.53596377
36	Long nose (HP:0003189)	2.51323286
37	Progressive inability to walk (HP:0002505)	2.50204657
38	Cerebellar dysplasia (HP:0007033)	2.49303328
39	Ulnar claw (HP:0001178)	2.49078673
40	Abnormal platelet volume (HP:0011876)	2.48033912
41	Abnormality of the costochondral junction (HP:0000919)	2.45276563
42	Retinal dysplasia (HP:0007973)	2.44327548
43	Pachygyria (HP:0001302)	2.43205309
44	Visual hallucinations (HP:0002367)	2.37371829
45	Pendular nystagmus (HP:0012043)	2.35962971
46	Congenital stationary night blindness (HP:0007642)	2.35791318
47	Abnormal ciliary motility (HP:0012262)	2.32605046
48	Sclerocornea (HP:0000647)	2.30131162
49	Inability to walk (HP:0002540)	2.27634251
50	Supernumerary spleens (HP:0009799)	2.16083151
51	Optic nerve hypoplasia (HP:0000609)	2.15426812
52	Polydipsia (HP:0001959)	2.14242422
53	Abnormal drinking behavior (HP:0030082)	2.14242422
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.13062391
55	Medial flaring of the eyebrow (HP:0010747)	2.13027882
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.12841757
57	Abolished electroretinogram (ERG) (HP:0000550)	2.12365472
58	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.10953969
59	Congenital hepatic fibrosis (HP:0002612)	2.10347352
60	Metabolic alkalosis (HP:0200114)	2.08691750
61	Chronic hepatic failure (HP:0100626)	2.07667638
62	Bone cyst (HP:0012062)	2.05564662
63	Abnormal respiratory motile cilium physiology (HP:0012261)	2.04827708
64	Delayed CNS myelination (HP:0002188)	2.03413564
65	Attenuation of retinal blood vessels (HP:0007843)	2.03105453
66	Congenital sensorineural hearing impairment (HP:0008527)	2.02042745
67	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.98964062
68	Absence seizures (HP:0002121)	1.95824563
69	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.94994206
70	Genetic anticipation (HP:0003743)	1.94107751
71	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.94018113
72	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.90482258
73	Anencephaly (HP:0002323)	1.88819114
74	Abnormality of fatty-acid metabolism (HP:0004359)	1.88739414
75	Microretrognathia (HP:0000308)	1.87808154
76	Postaxial foot polydactyly (HP:0001830)	1.85223654
77	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.84344651
78	Occipital encephalocele (HP:0002085)	1.84287514
79	Decreased central vision (HP:0007663)	1.82752594
80	Dandy-Walker malformation (HP:0001305)	1.80654037
81	Male pseudohermaphroditism (HP:0000037)	1.78611198
82	Nausea (HP:0002018)	1.78371298
83	Tinnitus (HP:0000360)	1.76192423
84	Thyroid-stimulating hormone excess (HP:0002925)	1.74377315
85	Short hallux (HP:0010109)	1.73472214
86	Constricted visual fields (HP:0001133)	1.72651888
87	Adrenal hypoplasia (HP:0000835)	1.72482505
88	Arthropathy (HP:0003040)	1.71421881
89	Bulbous nose (HP:0000414)	1.70994164
90	Abnormal protein N-linked glycosylation (HP:0012347)	1.70866596
91	Abnormal protein glycosylation (HP:0012346)	1.70866596
92	Abnormal glycosylation (HP:0012345)	1.70866596
93	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.70866596
94	Barrel-shaped chest (HP:0001552)	1.69517975
95	Purpura (HP:0000979)	1.68642753
96	Hypoplasia of the pons (HP:0012110)	1.67607509
97	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.67028376
98	Cerebral hypomyelination (HP:0006808)	1.66722325
99	Keratoconus (HP:0000563)	1.66567407
100	Increased corneal curvature (HP:0100692)	1.66567407

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	5.52097256
2	FRK	4.16076005
3	PINK1	3.75569393
4	ACVR1B	3.26063716
5	ADRBK2	3.18258519
6	BRSK2	3.15520770
7	TAOK3	3.13517022
8	BMPR1B	3.00383439
9	NUAK1	2.82968631
10	NTRK3	2.80430696
11	MARK1	2.50607857
12	WEE1	2.29964715
13	DYRK2	2.22699344
14	BCKDK	2.10900194
15	SIK2	2.04777914
16	TIE1	1.99083717
17	GRK1	1.95663264
18	MAP4K2	1.88182604
19	MAPK13	1.85904285
20	ADRBK1	1.62896711
21	PIK3CG	1.50001958
22	TGFBR1	1.42854485
23	MST4	1.32971929
24	PRKD3	1.19355908
25	DAPK2	1.12910439
26	PIK3CA	1.08729615
27	SRPK1	1.07354647
28	GRK5	0.97954792
29	MAP2K1	0.97579463
30	FLT3	0.96558185
31	MATK	0.94688059
32	RIPK4	0.94662770
33	AKT3	0.94545320
34	TEC	0.90419200
35	HIPK2	0.90252265
36	PRKCG	0.84511077
37	BMX	0.78031061
38	SYK	0.76046464
39	MAP3K7	0.75211630
40	VRK1	0.74039322
41	MAP3K5	0.72942279
42	STK39	0.65443531
43	IRAK2	0.63988316
44	MAP2K2	0.62569845
45	CSNK1G3	0.59478467
46	PRKCE	0.58912489
47	NTRK2	0.58316485
48	INSRR	0.58292473
49	NLK	0.57808356
50	ITK	0.56493824
51	RPS6KA6	0.55859264
52	WNK4	0.54700105
53	CSNK1A1	0.53682107
54	WNK3	0.53008640
55	MAP2K4	0.52902966
56	PKN1	0.51882891
57	BRSK1	0.51308652
58	IGF1R	0.51200191
59	SGK2	0.50442793
60	CSF1R	0.49895660
61	PRKCZ	0.47534751
62	STK3	0.47080430
63	DAPK1	0.46111466
64	EPHA4	0.45707536
65	DAPK3	0.45430551
66	PRKCQ	0.44199990
67	NTRK1	0.44094334
68	SGK223	0.43715565
69	SGK494	0.43715565
70	BTK	0.43502388
71	CSNK1G2	0.42423776
72	CSNK1D	0.41850921
73	CSNK1G1	0.41751674
74	BRAF	0.41573366
75	PTK2B	0.40442964
76	RPS6KA5	0.39428772
77	CASK	0.39311054
78	TLK1	0.39218200
79	MAP3K4	0.37702365
80	MAP3K11	0.37258245
81	MAPKAPK3	0.36730193
82	ERBB2	0.34296131
83	CAMK2A	0.33680430
84	PRKCD	0.32776410
85	IKBKB	0.32764875
86	CDK19	0.32480731
87	PRKG1	0.31697225
88	AKT1	0.31361580
89	ILK	0.31312047
90	OXSR1	0.30351447
91	LYN	0.29847423
92	PRKACG	0.29509077
93	CSNK1A1L	0.29492451
94	PRKACA	0.29084679
95	PRKCA	0.28964207
96	ZAK	0.27692635
97	MELK	0.27232217
98	GRK7	0.26047512
99	PRKCB	0.25711853
100	ABL2	0.25658327

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	3.07997227
2	Nitrogen metabolism_Homo sapiens_hsa00910	2.96940951
3	Selenocompound metabolism_Homo sapiens_hsa00450	2.93873166
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.87725532
5	Phototransduction_Homo sapiens_hsa04744	2.87343995
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.81189956
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.76709180
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.67764711
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.54884473
10	Caffeine metabolism_Homo sapiens_hsa00232	2.41244414
11	One carbon pool by folate_Homo sapiens_hsa00670	2.22606204
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.20531018
13	Butanoate metabolism_Homo sapiens_hsa00650	2.11851068
14	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.01125626
15	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.00260572
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.92012171
17	Platelet activation_Homo sapiens_hsa04611	1.63997067
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.59553725
19	Nicotine addiction_Homo sapiens_hsa05033	1.56024868
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.54782701
21	Olfactory transduction_Homo sapiens_hsa04740	1.53451437
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.48028300
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.46521721
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.42147325
25	Serotonergic synapse_Homo sapiens_hsa04726	1.34698917
26	Taste transduction_Homo sapiens_hsa04742	1.24379829
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.23898170
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.18350337
29	Sulfur metabolism_Homo sapiens_hsa00920	1.17894880
30	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.12009249
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.09461364
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06212595
33	Circadian entrainment_Homo sapiens_hsa04713	1.05555116
34	Morphine addiction_Homo sapiens_hsa05032	1.05459526
35	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.04368553
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98120731
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.97548757
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.96413478
39	Long-term depression_Homo sapiens_hsa04730	0.95328824
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91298156
41	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.91208454
42	Homologous recombination_Homo sapiens_hsa03440	0.89969445
43	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.89311764
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.88050900
45	Oxidative phosphorylation_Homo sapiens_hsa00190	0.85519704
46	Peroxisome_Homo sapiens_hsa04146	0.84397671
47	Parkinsons disease_Homo sapiens_hsa05012	0.84141865
48	Propanoate metabolism_Homo sapiens_hsa00640	0.83924416
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81780713
50	Asthma_Homo sapiens_hsa05310	0.81615061
51	Glutathione metabolism_Homo sapiens_hsa00480	0.79102627
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.78088825
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.76306168
54	Non-homologous end-joining_Homo sapiens_hsa03450	0.76076402
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74950123
56	RNA polymerase_Homo sapiens_hsa03020	0.73236640
57	Basal transcription factors_Homo sapiens_hsa03022	0.73087319
58	Ribosome_Homo sapiens_hsa03010	0.71590016
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.71172250
60	Salivary secretion_Homo sapiens_hsa04970	0.70316015
61	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.68867734
62	Glutamatergic synapse_Homo sapiens_hsa04724	0.67552641
63	Fatty acid elongation_Homo sapiens_hsa00062	0.66130811
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.61894504
65	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59954069
66	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.59184592
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.59065384
68	Rap1 signaling pathway_Homo sapiens_hsa04015	0.57041964
69	Mineral absorption_Homo sapiens_hsa04978	0.56488260
70	Fatty acid degradation_Homo sapiens_hsa00071	0.54185989
71	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.53803136
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.53521006
73	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.53320558
74	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.52861332
75	Sulfur relay system_Homo sapiens_hsa04122	0.51359266
76	Ras signaling pathway_Homo sapiens_hsa04014	0.50120947
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.50060726
78	Insulin secretion_Homo sapiens_hsa04911	0.49418632
79	Purine metabolism_Homo sapiens_hsa00230	0.48750624
80	Alcoholism_Homo sapiens_hsa05034	0.48665412
81	PPAR signaling pathway_Homo sapiens_hsa03320	0.48624338
82	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.46052289
83	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.43217259
84	Huntingtons disease_Homo sapiens_hsa05016	0.42883390
85	Melanoma_Homo sapiens_hsa05218	0.42791822
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42604599
87	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.41804654
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41468086
89	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.40213463
90	ECM-receptor interaction_Homo sapiens_hsa04512	0.39433449
91	Alzheimers disease_Homo sapiens_hsa05010	0.39345993
92	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.39135566
93	Circadian rhythm_Homo sapiens_hsa04710	0.37938517
94	ABC transporters_Homo sapiens_hsa02010	0.36868090
95	Metabolic pathways_Homo sapiens_hsa01100	0.36123754
96	Hippo signaling pathway_Homo sapiens_hsa04390	0.36028441
97	RNA degradation_Homo sapiens_hsa03018	0.35522879
98	Allograft rejection_Homo sapiens_hsa05330	0.35320473
99	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.34629361
100	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.33118984

AGGF1P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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