AGGF1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to redox state (GO:0051775)6.95985892
2short-term memory (GO:0007614)6.06040118
3positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)5.92859312
4axoneme assembly (GO:0035082)5.85804317
5prenylation (GO:0097354)5.78751880
6protein prenylation (GO:0018342)5.78751880
7thalamus development (GO:0021794)5.34643653
8L-serine metabolic process (GO:0006563)5.32592642
9negative regulation of norepinephrine secretion (GO:0010700)5.14112292
10sequestering of actin monomers (GO:0042989)5.12385908
11organ formation (GO:0048645)5.02299941
12regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.01065052
13histone H3-K4 trimethylation (GO:0080182)4.84424081
14fibroblast migration (GO:0010761)4.75430713
15negative regulation of smooth muscle cell differentiation (GO:0051151)4.70394651
16renal system development (GO:0072001)4.59423609
17establishment of nucleus localization (GO:0040023)4.52926637
18regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)4.43658856
19RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)4.40865642
20protein heterotetramerization (GO:0051290)4.40550447
21protein-cofactor linkage (GO:0018065)4.39114461
22limb bud formation (GO:0060174)4.31249563
23regulation of microtubule depolymerization (GO:0031114)4.25067023
24cerebellar Purkinje cell layer development (GO:0021680)4.14610754
25regulation of secondary heart field cardioblast proliferation (GO:0003266)4.09720805
26regulation of cardioblast proliferation (GO:0003264)4.09720805
27neurotransmitter catabolic process (GO:0042135)3.96249062
28negative regulation of systemic arterial blood pressure (GO:0003085)3.93610769
29regulation of DNA-templated transcription, initiation (GO:2000142)3.93129953
30hypotonic response (GO:0006971)3.90089379
31negative regulation of potassium ion transmembrane transport (GO:1901380)3.85527392
32layer formation in cerebral cortex (GO:0021819)3.85429963
33microtubule bundle formation (GO:0001578)3.84715610
34positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.81482115
35negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.74825173
36negative regulation of microtubule depolymerization (GO:0007026)3.74491930
37positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.72599229
38pancreas development (GO:0031016)3.68531441
39intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)3.67455425
40positive regulation of DNA-templated transcription, initiation (GO:2000144)3.61277367
41positive regulation of ERBB signaling pathway (GO:1901186)3.55770156
42nonmotile primary cilium assembly (GO:0035058)3.55349859
43rRNA catabolic process (GO:0016075)3.50232595
44regulation of autophagic vacuole assembly (GO:2000785)3.49037915
45adrenergic receptor signaling pathway (GO:0071875)3.47642383
46regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.46490774
47hypothalamus development (GO:0021854)3.44312827
48lung vasculature development (GO:0060426)3.42951133
49peptidyl-lysine trimethylation (GO:0018023)3.37975720
50protoporphyrinogen IX biosynthetic process (GO:0006782)3.37348807
51mechanosensory behavior (GO:0007638)3.37108860
52protein polyglutamylation (GO:0018095)3.37082898
53phosphatidylglycerol biosynthetic process (GO:0006655)3.34435223
54negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.33720276
55forebrain morphogenesis (GO:0048853)3.25214764
56artery development (GO:0060840)3.24687153
57negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.22467190
58negative regulation of catecholamine secretion (GO:0033604)3.20134949
59retinal ganglion cell axon guidance (GO:0031290)3.18680742
60regulation of vacuole organization (GO:0044088)3.15207822
61regulation of type B pancreatic cell apoptotic process (GO:2000674)3.11555474
62spinal cord motor neuron differentiation (GO:0021522)3.09982563
63regulation of female receptivity (GO:0045924)3.09243118
64heart field specification (GO:0003128)3.06971762
65secondary heart field specification (GO:0003139)3.06971762
66negative regulation of DNA biosynthetic process (GO:2000279)3.04680620
67endocardial cushion morphogenesis (GO:0003203)3.00711621
68cardiac right ventricle morphogenesis (GO:0003215)3.00387683
69positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.00266619
70otic vesicle formation (GO:0030916)2.99942971
71regulation of uterine smooth muscle contraction (GO:0070472)2.98763646
72regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.96415490
73RNA phosphodiester bond hydrolysis (GO:0090501)2.94985844
74neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.92351544
75positive regulation of dendritic spine development (GO:0060999)2.91087300
76positive regulation of CREB transcription factor activity (GO:0032793)2.89135725
77lung-associated mesenchyme development (GO:0060484)2.86985244
78negative regulation of transcription regulatory region DNA binding (GO:2000678)2.86448271
79piRNA metabolic process (GO:0034587)2.86010927
80regulation of microtubule polymerization or depolymerization (GO:0031110)2.84834629
81killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.84398131
82disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.84398131
83embryonic foregut morphogenesis (GO:0048617)2.83018551
84middle ear morphogenesis (GO:0042474)2.81919995
85regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.81205813
86regulation of action potential (GO:0098900)2.80648265
87somite development (GO:0061053)2.80305397
88regulation of nuclear cell cycle DNA replication (GO:0033262)2.78408736
89serine family amino acid biosynthetic process (GO:0009070)2.77416045
90protoporphyrinogen IX metabolic process (GO:0046501)2.77286442
91mitochondrion distribution (GO:0048311)2.76720582
92respiratory chain complex IV assembly (GO:0008535)2.73942023
93thyroid gland development (GO:0030878)2.73460679
94cullin deneddylation (GO:0010388)2.69793885
95regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.69578192
96regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.69430046
97positive regulation of DNA-dependent DNA replication (GO:2000105)2.68180883
98central nervous system neuron development (GO:0021954)2.63509271
99monoubiquitinated protein deubiquitination (GO:0035520)2.63045344
100protein neddylation (GO:0045116)11.3638329

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.82908934
2EZH2_22144423_ChIP-Seq_EOC_Human4.11413716
3ZNF263_19887448_ChIP-Seq_K562_Human2.81005125
4ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65569014
5BMI1_23680149_ChIP-Seq_NPCS_Mouse2.30070427
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.27480807
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24573545
8IGF1R_20145208_ChIP-Seq_DFB_Human2.24546319
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08303642
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.06098798
11ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.02929892
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse11.0715215
13PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95568975
14RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70974567
15ZNF274_21170338_ChIP-Seq_K562_Hela1.70273557
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65908499
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64817447
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58312752
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56200282
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53474258
21P300_19829295_ChIP-Seq_ESCs_Human1.52701605
22AR_21572438_ChIP-Seq_LNCaP_Human1.52576921
23ELK1_19687146_ChIP-ChIP_HELA_Human1.48316439
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.45387278
25TP53_22573176_ChIP-Seq_HFKS_Human1.44155763
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43558210
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42151916
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42151916
29GBX2_23144817_ChIP-Seq_PC3_Human1.40763478
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39190060
31FUS_26573619_Chip-Seq_HEK293_Human1.39136506
32TCF4_22108803_ChIP-Seq_LS180_Human1.35892849
33VDR_23849224_ChIP-Seq_CD4+_Human1.34609926
34TAF15_26573619_Chip-Seq_HEK293_Human1.33132313
35HTT_18923047_ChIP-ChIP_STHdh_Human1.32886008
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30949910
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25333380
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24980007
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23962290
40EWS_26573619_Chip-Seq_HEK293_Human1.23477575
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21203792
42CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20119675
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.20058465
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19311396
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19309161
46TCF4_23295773_ChIP-Seq_U87_Human1.15316150
47SALL4_22934838_ChIP-ChIP_CD34+_Human1.15192663
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14751153
49TP53_16413492_ChIP-PET_HCT116_Human1.14497283
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13861099
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13457423
52SMAD4_21799915_ChIP-Seq_A2780_Human1.12462766
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10474369
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09919037
55SCL_19346495_ChIP-Seq_HPC-7_Human1.07280975
56NANOG_19829295_ChIP-Seq_ESCs_Human1.05847389
57SOX2_19829295_ChIP-Seq_ESCs_Human1.05847389
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.05279044
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03200876
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.02400388
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01029404
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00689064
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00279450
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99777282
65STAT3_23295773_ChIP-Seq_U87_Human0.98992704
66EZH2_27294783_Chip-Seq_NPCs_Mouse0.98439622
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97985164
68P300_18555785_Chip-Seq_ESCs_Mouse0.97447958
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97374436
70SMAD4_21741376_ChIP-Seq_EPCs_Human0.95800237
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95478647
72NFE2_27457419_Chip-Seq_LIVER_Mouse0.95446491
73REST_18959480_ChIP-ChIP_MESCs_Mouse0.94209834
74REST_21632747_ChIP-Seq_MESCs_Mouse0.93814261
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92863723
76CDX2_22108803_ChIP-Seq_LS180_Human0.92461104
77ER_23166858_ChIP-Seq_MCF-7_Human0.92192702
78E2F1_18555785_Chip-Seq_ESCs_Mouse0.90513842
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90380610
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89889241
81ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89738531
82RARB_27405468_Chip-Seq_BRAIN_Mouse0.87781740
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87662802
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87261451
85SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86993449
86OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86574571
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86266529
88SMAD3_21741376_ChIP-Seq_EPCs_Human0.86050102
89GATA3_21878914_ChIP-Seq_MCF-7_Human0.85492258
90RNF2_27304074_Chip-Seq_NSC_Mouse0.85330618
91E2F7_22180533_ChIP-Seq_HELA_Human0.84757299
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.84687465
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84306853
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84263476
95SOX2_18555785_Chip-Seq_ESCs_Mouse0.83242285
96P53_22387025_ChIP-Seq_ESCs_Mouse0.83149577
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83026417
98EED_16625203_ChIP-ChIP_MESCs_Mouse0.82309667
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81858521
100E2F1_17053090_ChIP-ChIP_MCF-7_Human0.81267097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after3.74668830
2MP0004147_increased_porphyrin_level3.27010966
3MP0002735_abnormal_chemical_nociception2.83942898
4MP0009780_abnormal_chondrocyte_physiolo2.83870948
5MP0003283_abnormal_digestive_organ2.80382922
6MP0001188_hyperpigmentation2.69293973
7MP0002876_abnormal_thyroid_physiology2.65344990
8MP0002249_abnormal_larynx_morphology2.56342074
9MP0003646_muscle_fatigue2.52301879
10MP0003122_maternal_imprinting2.49912979
11MP0003186_abnormal_redox_activity2.43229808
12MP0003123_paternal_imprinting2.42288618
13MP0001968_abnormal_touch/_nociception2.25940990
14MP0001984_abnormal_olfaction2.25302457
15MP0002282_abnormal_trachea_morphology2.20521022
16MP0009046_muscle_twitch2.17948880
17MP0000631_abnormal_neuroendocrine_gland2.15674083
18MP0002751_abnormal_autonomic_nervous1.97620851
19MP0000537_abnormal_urethra_morphology1.97253738
20MP0003941_abnormal_skin_development1.96536444
21MP0005367_renal/urinary_system_phenotyp1.95946422
22MP0000516_abnormal_urinary_system1.95946422
23MP0000049_abnormal_middle_ear1.88298943
24MP0008569_lethality_at_weaning1.82498595
25MP0001293_anophthalmia1.81612444
26MP0002557_abnormal_social/conspecific_i1.79167089
27MP0004142_abnormal_muscle_tone1.76066276
28MP0001440_abnormal_grooming_behavior1.75273606
29MP0008877_abnormal_DNA_methylation1.68310512
30MP0003121_genomic_imprinting1.67657689
31MP0006072_abnormal_retinal_apoptosis1.66871797
32MP0004145_abnormal_muscle_electrophysio1.59468367
33MP0003937_abnormal_limbs/digits/tail_de1.59188722
34MP0008775_abnormal_heart_ventricle1.58561474
35MP0003755_abnormal_palate_morphology1.58222747
36MP0000681_abnormal_thyroid_gland1.58220051
37MP0001919_abnormal_reproductive_system1.57361866
38MP0002184_abnormal_innervation1.55621352
39MP0003119_abnormal_digestive_system1.52238463
40MP0002234_abnormal_pharynx_morphology1.51619341
41MP0002132_abnormal_respiratory_system1.48447884
42MP0005551_abnormal_eye_electrophysiolog1.47305166
43MP0002063_abnormal_learning/memory/cond1.45150580
44MP0005365_abnormal_bile_salt1.44139593
45MP0004130_abnormal_muscle_cell1.43952036
46MP0005257_abnormal_intraocular_pressure1.40639181
47MP0002009_preneoplasia1.39253656
48MP0002177_abnormal_outer_ear1.37124412
49MP0005220_abnormal_exocrine_pancreas1.34551138
50MP0008875_abnormal_xenobiotic_pharmacok1.29149767
51MP0004885_abnormal_endolymph1.28583571
52MP0008007_abnormal_cellular_replicative1.27832871
53MP0000427_abnormal_hair_cycle1.27225806
54MP0003638_abnormal_response/metabolism_1.23505171
55MP0000955_abnormal_spinal_cord1.22278443
56MP0002089_abnormal_postnatal_growth/wei1.17904614
57MP0002160_abnormal_reproductive_system1.12053986
58MP0006054_spinal_hemorrhage1.10435816
59MP0002572_abnormal_emotion/affect_behav1.08844267
60MP0009053_abnormal_anal_canal1.07514005
61MP0002067_abnormal_sensory_capabilities1.07156576
62MP0002837_dystrophic_cardiac_calcinosis1.05582701
63MP0003935_abnormal_craniofacial_develop1.05451423
64MP0006276_abnormal_autonomic_nervous1.05349535
65MP0002102_abnormal_ear_morphology1.04660654
66MP0000230_abnormal_systemic_arterial0.99445458
67MP0000377_abnormal_hair_follicle0.99251583
68MP0008872_abnormal_physiological_respon0.98980596
69MP0000778_abnormal_nervous_system0.98652192
70MP0002932_abnormal_joint_morphology0.96463596
71MP0004742_abnormal_vestibular_system0.96178353
72MP0002090_abnormal_vision0.95788755
73MP0003787_abnormal_imprinting0.93412932
74MP0002697_abnormal_eye_size0.92706064
75MP0002233_abnormal_nose_morphology0.90616135
76MP0001486_abnormal_startle_reflex0.89832696
77MP0009745_abnormal_behavioral_response0.89042650
78MP0002272_abnormal_nervous_system0.88414986
79MP0002752_abnormal_somatic_nervous0.87797554
80MP0002928_abnormal_bile_duct0.87486508
81MP0003938_abnormal_ear_development0.87464333
82MP0003656_abnormal_erythrocyte_physiolo0.86411835
83MP0001756_abnormal_urination0.85622962
84MP0005389_reproductive_system_phenotype0.85360763
85MP0003880_abnormal_central_pattern0.85266211
86MP0003385_abnormal_body_wall0.82266874
87MP0002733_abnormal_thermal_nociception0.81617901
88MP0001286_abnormal_eye_development0.81559252
89MP0002116_abnormal_craniofacial_bone0.77319075
90MP0005391_vision/eye_phenotype0.74396450
91MP0002006_tumorigenesis0.73691913
92MP0001944_abnormal_pancreas_morphology0.72414183
93MP0003633_abnormal_nervous_system0.72294130
94MP0001970_abnormal_pain_threshold0.71577495
95MP0002064_seizures0.70822721
96MP0004811_abnormal_neuron_physiology0.69944024
97MP0000358_abnormal_cell_content/0.69117859
98MP0002095_abnormal_skin_pigmentation0.68578376
99MP0002069_abnormal_eating/drinking_beha0.68108772
100MP0002938_white_spotting0.67968288

Predicted human phenotypes

RankGene SetZ-score
1Deep palmar crease (HP:0006191)7.77476279
2Facial cleft (HP:0002006)6.81056136
3Broad-based gait (HP:0002136)5.32084489
4Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.76906515
5Abnormality of the aortic arch (HP:0012303)3.75348112
6Hepatocellular necrosis (HP:0001404)3.63372309
7Bilateral microphthalmos (HP:0007633)3.61696494
8Limb hypertonia (HP:0002509)3.57918589
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.43102779
10Curly hair (HP:0002212)3.37397703
11Capillary hemangiomas (HP:0005306)3.30901482
12Hyperglycinemia (HP:0002154)3.30326515
13Impulsivity (HP:0100710)3.14221270
14Disinhibition (HP:0000734)3.09924390
15Wide intermamillary distance (HP:0006610)3.06183862
16Cutaneous finger syndactyly (HP:0010554)3.01391230
17Cerebral inclusion bodies (HP:0100314)3.00500045
18Abnormality of the lower motor neuron (HP:0002366)3.00495121
19Abnormality of the labia minora (HP:0012880)2.89635580
20Large eyes (HP:0001090)2.84012479
213-Methylglutaconic aciduria (HP:0003535)2.78295498
22Relative macrocephaly (HP:0004482)2.76405465
23Attenuation of retinal blood vessels (HP:0007843)2.74142496
24Aplasia/Hypoplasia of the sternum (HP:0006714)2.71348705
25Short tibia (HP:0005736)2.70893002
26Constricted visual fields (HP:0001133)2.67293239
27Hip dysplasia (HP:0001385)2.66535345
28Knee flexion contracture (HP:0006380)2.65109833
29Hepatic necrosis (HP:0002605)2.65000587
30Insidious onset (HP:0003587)2.61888794
31Termporal pattern (HP:0011008)2.61888794
32Gait imbalance (HP:0002141)2.60888800
33Cutaneous syndactyly (HP:0012725)2.58653765
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.53884251
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.52796454
36Bifid tongue (HP:0010297)2.51140446
37Acute encephalopathy (HP:0006846)2.51044501
38Ankle contracture (HP:0006466)2.45893958
39Genetic anticipation (HP:0003743)2.45718411
40Pancreatic cysts (HP:0001737)2.43870080
41Medial flaring of the eyebrow (HP:0010747)2.43610606
42Genital tract atresia (HP:0001827)2.41515580
43Vaginal atresia (HP:0000148)2.38333396
44Insomnia (HP:0100785)2.34983369
45Agitation (HP:0000713)2.34777691
46Absent eyebrow (HP:0002223)2.34563985
47Abnormality of the phalanges of the hallux (HP:0010057)2.34312866
48Nephrogenic diabetes insipidus (HP:0009806)2.31431967
49Short chin (HP:0000331)2.29579492
50Mitochondrial inheritance (HP:0001427)2.28779367
51Intention tremor (HP:0002080)2.28330657
52Congenital primary aphakia (HP:0007707)2.27544030
53Inappropriate behavior (HP:0000719)2.27149940
54Anophthalmia (HP:0000528)2.18006827
55Megalencephaly (HP:0001355)2.16807900
56Absent eyelashes (HP:0000561)2.15214456
57Polyphagia (HP:0002591)2.12561117
58Aplasia involving bones of the upper limbs (HP:0009823)2.11958466
59Aplasia of the phalanges of the hand (HP:0009802)2.11958466
60Aplasia involving bones of the extremities (HP:0009825)2.11958466
61Pheochromocytoma (HP:0002666)2.04555199
62Increased serum lactate (HP:0002151)2.03625982
63Increased CSF lactate (HP:0002490)1.98566894
64Facial hemangioma (HP:0000329)1.97711251
65Tented upper lip vermilion (HP:0010804)1.97216131
66Acute lymphatic leukemia (HP:0006721)1.97155429
67Disproportionate short-trunk short stature (HP:0003521)1.95972868
68Long palpebral fissure (HP:0000637)1.95728161
69Degeneration of the lateral corticospinal tracts (HP:0002314)1.94118321
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94118321
71Intestinal atresia (HP:0011100)1.93772181
72Cystic hygroma (HP:0000476)1.93511386
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92843591
74Poor coordination (HP:0002370)1.89293635
75Atresia of the external auditory canal (HP:0000413)1.89110850
76Neuroendocrine neoplasm (HP:0100634)1.86047570
77Abnormality of the thoracic spine (HP:0100711)1.85973298
78Myokymia (HP:0002411)1.85892041
79Progressive visual loss (HP:0000529)1.84684241
80Fibular aplasia (HP:0002990)1.81554640
81Hypoplasia of the odontoid process (HP:0003311)1.81534561
82High anterior hairline (HP:0009890)1.80667231
83Gonadotropin excess (HP:0000837)1.80476849
84Renal hypoplasia (HP:0000089)1.75213803
85Postaxial foot polydactyly (HP:0001830)1.72697853
86Diminished motivation (HP:0000745)1.72348608
87Abnormality of the metopic suture (HP:0005556)1.71517120
88Postaxial hand polydactyly (HP:0001162)1.70530099
89Abnormality of the heme biosynthetic pathway (HP:0010472)1.68746276
90Amyotrophic lateral sclerosis (HP:0007354)1.68311450
91Abnormality of the phalanges of the 5th finger (HP:0004213)1.67553861
92Acute necrotizing encephalopathy (HP:0006965)1.67348934
93Gaze-evoked nystagmus (HP:0000640)1.66830576
94Elfin facies (HP:0004428)1.66316221
95Abnormality of the proximal phalanges of the hand (HP:0009834)1.66196038
96Broad distal phalanx of finger (HP:0009836)1.65708308
97Restlessness (HP:0000711)1.64040952
98Preaxial hand polydactyly (HP:0001177)1.63091694
99Symphalangism affecting the phalanges of the hand (HP:0009773)1.62787879
100Scrotal hypoplasia (HP:0000046)1.62008362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.27204766
2AKT35.02456539
3TRIM284.85035064
4STK393.06455408
5SIK32.78102413
6WNK42.49402557
7OXSR12.24975659
8MAP3K32.23470256
9WNK12.06518137
10CDK192.05348606
11LIMK11.94687561
12BMPR1B1.92725755
13CASK1.84099228
14GRK11.76439165
15BCR1.63429725
16MINK11.59298067
17WNK31.53363866
18MST41.52434421
19MKNK21.40130067
20SGK21.34461389
21MAP4K21.32240373
22RPS6KA41.15316117
23TSSK61.15067668
24DYRK1A1.12642958
25TAOK31.11946915
26STK381.09640262
27FRK1.08352655
28SGK31.05313005
29SGK2231.01936709
30SGK4941.01936709
31BRAF1.00923394
32MET0.98081363
33TNIK0.93978694
34MKNK10.92729578
35CSNK1D0.90469327
36CHEK20.85067925
37MAP3K40.83942190
38STK30.83785313
39RPS6KA50.82660288
40PIK3CG0.80880714
41STK40.80161828
42BCKDK0.76677725
43NTRK20.76476799
44WEE10.76228156
45CSNK1A1L0.72385601
46MAPK130.72161420
47CSNK1G10.70543548
48ROCK10.70192740
49CSNK2A20.68698632
50SIK20.68653765
51ZAK0.67373708
52DYRK20.67162376
53NUAK10.66659193
54OBSCN0.65264187
55CSNK1E0.64837516
56PRKCG0.62962106
57CDK180.59651487
58PKN20.59319068
59DAPK30.59034714
60SGK10.57057012
61ATR0.56860780
62INSRR0.56558944
63EIF2AK30.56353181
64ABL20.54309296
65CSNK1A10.54281461
66KSR10.53823050
67FGFR20.52517951
68PHKG20.51301869
69PHKG10.51301869
70TEC0.50672360
71PRKCQ0.49869538
72CDK80.49668969
73FGFR10.49167599
74EIF2AK20.47506040
75CAMK2A0.47361277
76CDK140.46853509
77DYRK30.46809495
78CSNK1G20.46473081
79AKT10.46033765
80ERBB20.45843714
81GSK3A0.45479921
82PRKG10.43457637
83CDK150.41428443
84CAMK1G0.40933268
85CDC42BPA0.39816121
86CSNK2A10.38959525
87CDK11A0.38945982
88RPS6KA30.38680684
89PRKCE0.37567245
90EGFR0.35360317
91PLK30.35000235
92AKT20.34071239
93CAMK2D0.34033220
94CDK50.32974066
95PAK30.30676679
96PRKACA0.29106679
97PRKDC0.28640435
98PRKCI0.27734672
99PDGFRB0.27600783
100ADRBK20.26901254

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.14275510
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.84657736
3Basal transcription factors_Homo sapiens_hsa030223.09934679
4Vitamin B6 metabolism_Homo sapiens_hsa007502.97698505
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.70884776
6Phototransduction_Homo sapiens_hsa047442.52264941
7Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.50703986
8Cardiac muscle contraction_Homo sapiens_hsa042602.42360167
9Non-homologous end-joining_Homo sapiens_hsa034502.34312844
10Oxidative phosphorylation_Homo sapiens_hsa001901.99651178
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98373376
12Mismatch repair_Homo sapiens_hsa034301.91425654
13SNARE interactions in vesicular transport_Homo sapiens_hsa041301.74217230
14RNA polymerase_Homo sapiens_hsa030201.67568141
15Parkinsons disease_Homo sapiens_hsa050121.67369310
16RNA transport_Homo sapiens_hsa030131.59664312
17Propanoate metabolism_Homo sapiens_hsa006401.54050065
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.52543097
19Sulfur metabolism_Homo sapiens_hsa009201.52283468
20One carbon pool by folate_Homo sapiens_hsa006701.32618607
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30324647
22Alzheimers disease_Homo sapiens_hsa050101.25704563
23Glutathione metabolism_Homo sapiens_hsa004801.19796866
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18483274
25Glutamatergic synapse_Homo sapiens_hsa047241.11758054
26Olfactory transduction_Homo sapiens_hsa047401.11639441
27Huntingtons disease_Homo sapiens_hsa050161.10660397
28Renin secretion_Homo sapiens_hsa049241.05720022
29Linoleic acid metabolism_Homo sapiens_hsa005911.03146681
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03014710
31Salivary secretion_Homo sapiens_hsa049701.01130920
32Nitrogen metabolism_Homo sapiens_hsa009101.00951874
33Nicotine addiction_Homo sapiens_hsa050330.97094271
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95773459
35mTOR signaling pathway_Homo sapiens_hsa041500.93313866
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91111435
37Chemical carcinogenesis_Homo sapiens_hsa052040.85800716
38N-Glycan biosynthesis_Homo sapiens_hsa005100.85748536
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84688973
40Choline metabolism in cancer_Homo sapiens_hsa052310.83075681
41Circadian entrainment_Homo sapiens_hsa047130.83070257
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82440181
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80178824
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78677635
45Circadian rhythm_Homo sapiens_hsa047100.78255714
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76412190
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75606630
48Taste transduction_Homo sapiens_hsa047420.75282796
49DNA replication_Homo sapiens_hsa030300.74373429
50Proteasome_Homo sapiens_hsa030500.73543372
51Oocyte meiosis_Homo sapiens_hsa041140.73348960
52Butanoate metabolism_Homo sapiens_hsa006500.72705578
53Selenocompound metabolism_Homo sapiens_hsa004500.70614534
54GABAergic synapse_Homo sapiens_hsa047270.70418530
55Serotonergic synapse_Homo sapiens_hsa047260.69790534
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68999913
57Long-term depression_Homo sapiens_hsa047300.66433138
58Basal cell carcinoma_Homo sapiens_hsa052170.66165708
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65366917
60Oxytocin signaling pathway_Homo sapiens_hsa049210.64159541
61Morphine addiction_Homo sapiens_hsa050320.63982163
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63191613
63Purine metabolism_Homo sapiens_hsa002300.62009028
64Platelet activation_Homo sapiens_hsa046110.61839552
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61044089
66Ether lipid metabolism_Homo sapiens_hsa005650.60625809
67Gastric acid secretion_Homo sapiens_hsa049710.59594499
68Protein export_Homo sapiens_hsa030600.58606057
69Hedgehog signaling pathway_Homo sapiens_hsa043400.57855997
70Glioma_Homo sapiens_hsa052140.57702152
71Melanoma_Homo sapiens_hsa052180.56575235
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55317770
73Peroxisome_Homo sapiens_hsa041460.52824264
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52678025
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51419290
76Ribosome_Homo sapiens_hsa030100.49815040
77Pancreatic secretion_Homo sapiens_hsa049720.47774026
78Insulin secretion_Homo sapiens_hsa049110.45871853
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43912784
80cAMP signaling pathway_Homo sapiens_hsa040240.43659529
81Endometrial cancer_Homo sapiens_hsa052130.43405707
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43342322
83Dopaminergic synapse_Homo sapiens_hsa047280.43314619
84RNA degradation_Homo sapiens_hsa030180.42912437
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42282692
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41171267
87Hippo signaling pathway_Homo sapiens_hsa043900.40584026
88Renal cell carcinoma_Homo sapiens_hsa052110.40329344
89Dilated cardiomyopathy_Homo sapiens_hsa054140.40046309
90Ras signaling pathway_Homo sapiens_hsa040140.39870400
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39197466
92Glycerolipid metabolism_Homo sapiens_hsa005610.38231436
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.38158243
94beta-Alanine metabolism_Homo sapiens_hsa004100.37273072
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37101981
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36711839
97Amphetamine addiction_Homo sapiens_hsa050310.36106688
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35567546
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35297354
100Bile secretion_Homo sapiens_hsa049760.34899398

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