AGGF1P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)7.25874852
2protoporphyrinogen IX biosynthetic process (GO:0006782)6.61119637
3N-acetylneuraminate metabolic process (GO:0006054)6.53867129
4positive regulation of histone deacetylation (GO:0031065)5.99327927
5regulation of MHC class II biosynthetic process (GO:0045346)5.97718643
6positive regulation of protein deacetylation (GO:0090312)5.28312040
7protoporphyrinogen IX metabolic process (GO:0046501)5.04190538
8centriole assembly (GO:0098534)4.86553446
9G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.79256083
10cellular extravasation (GO:0045123)4.78735007
11N-acetylglucosamine metabolic process (GO:0006044)4.77383905
12behavioral response to nicotine (GO:0035095)4.56794970
13positive regulation of chemokine biosynthetic process (GO:0045080)4.06638306
14kynurenine metabolic process (GO:0070189)4.03448444
15amino sugar catabolic process (GO:0046348)3.99967857
16base-excision repair, AP site formation (GO:0006285)3.97923016
17indole-containing compound catabolic process (GO:0042436)3.97638844
18indolalkylamine catabolic process (GO:0046218)3.97638844
19tryptophan catabolic process (GO:0006569)3.97638844
20insulin-like growth factor receptor signaling pathway (GO:0048009)3.91119324
21thalamus development (GO:0021794)3.90311104
22regulation of chemokine biosynthetic process (GO:0045073)3.85929316
23microglial cell activation (GO:0001774)3.77979099
24tachykinin receptor signaling pathway (GO:0007217)3.73072059
25modulation of growth of symbiont involved in interaction with host (GO:0044144)3.70627718
26regulation of growth of symbiont in host (GO:0044126)3.70627718
27negative regulation of growth of symbiont in host (GO:0044130)3.70627718
28negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.70627718
29regulation of histone deacetylation (GO:0031063)3.62557188
30response to misfolded protein (GO:0051788)3.61895540
31regulation of action potential (GO:0098900)3.58776538
32disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.48001979
33killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.48001979
34reactive oxygen species biosynthetic process (GO:1903409)3.46512569
35reciprocal meiotic recombination (GO:0007131)3.43148551
36reciprocal DNA recombination (GO:0035825)3.43148551
37central nervous system projection neuron axonogenesis (GO:0021952)3.42970965
38epithelial cilium movement (GO:0003351)3.41672864
39purine deoxyribonucleotide catabolic process (GO:0009155)3.41488869
40behavioral response to ethanol (GO:0048149)3.39552690
41neutrophil mediated immunity (GO:0002446)3.22428086
42prostate gland growth (GO:0060736)3.21184928
43seminiferous tubule development (GO:0072520)3.21047182
44tryptophan metabolic process (GO:0006568)3.17576169
45central nervous system neuron axonogenesis (GO:0021955)3.16315370
46limb bud formation (GO:0060174)3.14514206
47heme biosynthetic process (GO:0006783)3.13054673
48regulation of protein deacetylation (GO:0090311)3.09401641
49response to folic acid (GO:0051593)3.08920724
50somatic diversification of immunoglobulins (GO:0016445)3.03881261
51negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.02925549
52cytokinetic process (GO:0032506)3.00663275
53aromatic amino acid family catabolic process (GO:0009074)3.00581813
54indolalkylamine metabolic process (GO:0006586)3.00534838
55glucosamine-containing compound metabolic process (GO:1901071)2.98348607
56neural tube formation (GO:0001841)2.98193746
57ventricular system development (GO:0021591)2.96662483
58negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.95797863
59positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.94924036
60response to pheromone (GO:0019236)2.93330061
61glutamate receptor signaling pathway (GO:0007215)2.92588069
62neuronal action potential propagation (GO:0019227)2.91024815
63phosphatidylethanolamine metabolic process (GO:0046337)2.90138722
64defense response to fungus (GO:0050832)2.86098988
65DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.84190865
66neuronal action potential (GO:0019228)2.83680348
67cellular ketone body metabolic process (GO:0046950)2.83640967
68cellular response to superoxide (GO:0071451)2.82023596
69cellular response to oxygen radical (GO:0071450)2.82023596
70removal of superoxide radicals (GO:0019430)2.82023596
71negative regulation of multicellular organism growth (GO:0040015)2.81147026
72ketone body metabolic process (GO:1902224)2.75930181
73detection of light stimulus involved in sensory perception (GO:0050962)2.75335780
74detection of light stimulus involved in visual perception (GO:0050908)2.75335780
75pyrimidine dimer repair (GO:0006290)2.73670514
76regulation of memory T cell differentiation (GO:0043380)2.73403659
77somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.73247098
78isotype switching (GO:0045190)2.73247098
79somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.73247098
80phosphatidylethanolamine biosynthetic process (GO:0006646)2.72969272
81negative regulation of mast cell activation (GO:0033004)2.69842219
82disruption of cells of other organism (GO:0044364)2.69625923
83killing of cells of other organism (GO:0031640)2.69625923
84response to oxygen radical (GO:0000305)2.69587815
85early endosome to late endosome transport (GO:0045022)2.67568063
86cerebral cortex radially oriented cell migration (GO:0021799)2.67421821
87protein polyglutamylation (GO:0018095)2.66429150
88synaptic transmission, cholinergic (GO:0007271)2.64002287
89cellular response to cadmium ion (GO:0071276)2.60963019
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.60573103
91misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.59705540
92sex differentiation (GO:0007548)2.59621467
93cilium movement (GO:0003341)2.59041347
94acrosome reaction (GO:0007340)2.56595466
95macrophage chemotaxis (GO:0048246)2.56512196
96fucose catabolic process (GO:0019317)2.54864648
97L-fucose metabolic process (GO:0042354)2.54864648
98L-fucose catabolic process (GO:0042355)2.54864648
99regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.53384913
100regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.53384913

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human4.29832269
2IGF1R_20145208_ChIP-Seq_DFB_Human4.10994531
3GBX2_23144817_ChIP-Seq_PC3_Human3.71121880
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.26622992
5VDR_22108803_ChIP-Seq_LS180_Human2.97054377
6EZH2_22144423_ChIP-Seq_EOC_Human2.70399968
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.68166445
8ZNF274_21170338_ChIP-Seq_K562_Hela2.64536377
9ER_23166858_ChIP-Seq_MCF-7_Human2.61630142
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51601064
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39723019
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.35952977
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.31928486
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09992900
15TAF15_26573619_Chip-Seq_HEK293_Human2.04993409
16BCAT_22108803_ChIP-Seq_LS180_Human1.92972947
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89766833
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88216265
19P300_19829295_ChIP-Seq_ESCs_Human1.87969171
20FUS_26573619_Chip-Seq_HEK293_Human1.87505754
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.80133094
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75602744
23EWS_26573619_Chip-Seq_HEK293_Human1.75493628
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74107942
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73291421
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72658145
27TCF4_23295773_ChIP-Seq_U87_Human1.66984084
28STAT3_23295773_ChIP-Seq_U87_Human1.66754522
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65160752
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.64328810
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.63086245
32SMAD4_21799915_ChIP-Seq_A2780_Human1.61492965
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60009202
34IRF1_19129219_ChIP-ChIP_H3396_Human1.58325371
35EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.58323546
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.54315757
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52088595
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50132177
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49152332
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.48936009
41KLF5_20875108_ChIP-Seq_MESCs_Mouse1.46757553
42CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.46371294
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45721325
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44338179
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43092989
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40842569
47TCF4_22108803_ChIP-Seq_LS180_Human1.39896624
48CBP_20019798_ChIP-Seq_JUKART_Human1.36791176
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36791176
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.36394734
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.36029785
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35062396
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.32281342
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30508283
55SOX2_19829295_ChIP-Seq_ESCs_Human1.29625853
56NANOG_19829295_ChIP-Seq_ESCs_Human1.29625853
57RUNX2_22187159_ChIP-Seq_PCA_Human1.28668705
58AR_25329375_ChIP-Seq_VCAP_Human1.28355332
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26806052
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26806052
61REST_21632747_ChIP-Seq_MESCs_Mouse1.26686798
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26500371
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25795917
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25200880
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22197248
66RXR_22108803_ChIP-Seq_LS180_Human1.21868442
67P53_22387025_ChIP-Seq_ESCs_Mouse1.20380566
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.19446958
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.19200658
70SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16438739
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14657265
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.14657265
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14402527
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13902801
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12958346
76CDX2_22108803_ChIP-Seq_LS180_Human1.12241788
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.12113730
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.10814002
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10226902
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09689179
81TP53_22573176_ChIP-Seq_HFKS_Human1.09465050
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08768172
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.08701240
84DROSHA_22980978_ChIP-Seq_HELA_Human1.07841517
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.07072319
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.06262974
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05863640
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04096059
89NCOR_22424771_ChIP-Seq_293T_Human1.03416273
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.03081026
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.02894850
92P300_18555785_Chip-Seq_ESCs_Mouse1.02260557
93HOXB7_26014856_ChIP-Seq_BT474_Human1.00843125
94KDM2B_26808549_Chip-Seq_REH_Human0.99423063
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.98788200
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98624639
97TBL1_22424771_ChIP-Seq_293T_Human0.98594895
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97435069
99OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95216923
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94459899

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract6.14407109
2MP0003252_abnormal_bile_duct4.10485777
3MP0008961_abnormal_basal_metabolism3.24940718
4MP0005670_abnormal_white_adipose3.19289799
5MP0008058_abnormal_DNA_repair2.96916391
6MP0004043_abnormal_pH_regulation2.94119914
7MP0001529_abnormal_vocalization2.93565658
8MP0000569_abnormal_digit_pigmentation2.68926301
9MP0002736_abnormal_nociception_after2.64251099
10MP0001968_abnormal_touch/_nociception2.61365744
11MP0005085_abnormal_gallbladder_physiolo2.53100098
12MP0005365_abnormal_bile_salt2.46571982
13MP0003195_calcinosis2.24845817
14MP0008872_abnormal_physiological_respon2.15821412
15MP0001501_abnormal_sleep_pattern2.13521986
16MP0004885_abnormal_endolymph2.11795121
17MP0002735_abnormal_chemical_nociception2.10313393
18MP0008057_abnormal_DNA_replication2.03008313
19MP0010386_abnormal_urinary_bladder2.01695512
20MP0005551_abnormal_eye_electrophysiolog1.98917481
21MP0002102_abnormal_ear_morphology1.95243213
22MP0009745_abnormal_behavioral_response1.71575623
23MP0010329_abnormal_lipoprotein_level1.67447769
24MP0004924_abnormal_behavior1.64729290
25MP0005386_behavior/neurological_phenoty1.64729290
26MP0004742_abnormal_vestibular_system1.64479326
27MP0008877_abnormal_DNA_methylation1.62588304
28MP0003880_abnormal_central_pattern1.59650516
29MP0009046_muscle_twitch1.53260591
30MP0003787_abnormal_imprinting1.51249766
31MP0002837_dystrophic_cardiac_calcinosis1.43926978
32MP0001502_abnormal_circadian_rhythm1.43134420
33MP0004270_analgesia1.42895979
34MP0005367_renal/urinary_system_phenotyp1.42884292
35MP0000516_abnormal_urinary_system1.42884292
36MP0002638_abnormal_pupillary_reflex1.39254478
37MP0002909_abnormal_adrenal_gland1.35460131
38MP0002272_abnormal_nervous_system1.33063133
39MP0005253_abnormal_eye_physiology1.32202019
40MP0001986_abnormal_taste_sensitivity1.31932853
41MP0002064_seizures1.31155454
42MP0000372_irregular_coat_pigmentation1.30785901
43MP0008875_abnormal_xenobiotic_pharmacok1.25607762
44MP0002067_abnormal_sensory_capabilities1.19715933
45MP0000631_abnormal_neuroendocrine_gland1.17499149
46MP0002572_abnormal_emotion/affect_behav1.17406346
47MP0003635_abnormal_synaptic_transmissio1.17203420
48MP0001486_abnormal_startle_reflex1.17120376
49MP0000015_abnormal_ear_pigmentation1.15899949
50MP0009115_abnormal_fat_cell1.12842926
51MP0002876_abnormal_thyroid_physiology1.10917438
52MP0004142_abnormal_muscle_tone1.10652050
53MP0000383_abnormal_hair_follicle1.10207362
54MP0001970_abnormal_pain_threshold1.08982046
55MP0005084_abnormal_gallbladder_morpholo1.07342162
56MP0001984_abnormal_olfaction1.05176928
57MP0000003_abnormal_adipose_tissue1.00909260
58MP0003121_genomic_imprinting1.00608731
59MP0005408_hypopigmentation1.00437196
60MP0002822_catalepsy0.97179673
61MP0002734_abnormal_mechanical_nocicepti0.96542472
62MP0006072_abnormal_retinal_apoptosis0.95552338
63MP0005646_abnormal_pituitary_gland0.90139762
64MP0000427_abnormal_hair_cycle0.89754033
65MP0002653_abnormal_ependyma_morphology0.86521953
66MP0002063_abnormal_learning/memory/cond0.85703883
67MP0002693_abnormal_pancreas_physiology0.85568252
68MP0002733_abnormal_thermal_nociception0.85518233
69MP0005334_abnormal_fat_pad0.84353321
70MP0003718_maternal_effect0.83410069
71MP0006292_abnormal_olfactory_placode0.79664867
72MP0004019_abnormal_vitamin_homeostasis0.77034195
73MP0002229_neurodegeneration0.76781645
74MP0000778_abnormal_nervous_system0.76264883
75MP0005410_abnormal_fertilization0.76210724
76MP0005448_abnormal_energy_balance0.74878295
77MP0002118_abnormal_lipid_homeostasis0.74351169
78MP0003123_paternal_imprinting0.74069822
79MP0002882_abnormal_neuron_morphology0.72675866
80MP0003011_delayed_dark_adaptation0.72650387
81MP0003878_abnormal_ear_physiology0.72221780
82MP0005377_hearing/vestibular/ear_phenot0.72221780
83MP0003698_abnormal_male_reproductive0.70688050
84MP0006276_abnormal_autonomic_nervous0.70026935
85MP0003890_abnormal_embryonic-extraembry0.69835933
86MP0000955_abnormal_spinal_cord0.69449120
87MP0005174_abnormal_tail_pigmentation0.68784628
88MP0002234_abnormal_pharynx_morphology0.67665509
89MP0001324_abnormal_eye_pigmentation0.67043870
90MP0003633_abnormal_nervous_system0.66538234
91MP0001270_distended_abdomen0.65767368
92MP0001944_abnormal_pancreas_morphology0.65105358
93MP0002078_abnormal_glucose_homeostasis0.64800706
94MP0009643_abnormal_urine_homeostasis0.64527482
95MP0003646_muscle_fatigue0.62832733
96MP0002095_abnormal_skin_pigmentation0.61646537
97MP0000230_abnormal_systemic_arterial0.61473218
98MP0005266_abnormal_metabolism0.61168410
99MP0002752_abnormal_somatic_nervous0.61102992
100MP0005195_abnormal_posterior_eye0.59932434

Predicted human phenotypes

RankGene SetZ-score
1Absent speech (HP:0001344)4.90993627
2Genetic anticipation (HP:0003743)4.63052808
3Hyperventilation (HP:0002883)4.48158283
4Progressive cerebellar ataxia (HP:0002073)4.36963158
5Protruding tongue (HP:0010808)4.13520702
6Broad-based gait (HP:0002136)3.87151206
7Gaze-evoked nystagmus (HP:0000640)3.74691241
8Molar tooth sign on MRI (HP:0002419)3.31207222
9Abnormality of midbrain morphology (HP:0002418)3.31207222
10Febrile seizures (HP:0002373)3.21992587
11Drooling (HP:0002307)3.08856549
12Abnormality of the prostate (HP:0008775)3.01819471
13Abnormality of the renal cortex (HP:0011035)3.01493190
14Pancreatic cysts (HP:0001737)2.97671573
15Exotropia (HP:0000577)2.94349703
16Widely spaced teeth (HP:0000687)2.93638446
17Conical tooth (HP:0000698)2.90368090
18Pendular nystagmus (HP:0012043)2.87182332
19Prostate neoplasm (HP:0100787)2.86408612
20Abnormality of the renal medulla (HP:0100957)2.85973576
21Nephronophthisis (HP:0000090)2.85287344
22Excessive salivation (HP:0003781)2.83735144
23True hermaphroditism (HP:0010459)2.82433133
24Fair hair (HP:0002286)2.75184798
25Progressive inability to walk (HP:0002505)2.70994904
26Action tremor (HP:0002345)2.69275129
27Intestinal atresia (HP:0011100)2.67871230
28Medial flaring of the eyebrow (HP:0010747)2.67408156
29Atonic seizures (HP:0010819)2.61613852
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.48592127
31Generalized hypopigmentation of hair (HP:0011358)2.47910654
32Inability to walk (HP:0002540)2.47791327
33Pancreatic fibrosis (HP:0100732)2.47576847
34Urinary bladder sphincter dysfunction (HP:0002839)2.44216214
35Congenital stationary night blindness (HP:0007642)2.41238271
36Keratoconus (HP:0000563)2.39771019
37Increased corneal curvature (HP:0100692)2.39771019
38Congenital sensorineural hearing impairment (HP:0008527)2.38290403
39Intellectual disability, progressive (HP:0006887)2.36766107
40Clumsiness (HP:0002312)2.35479083
41Focal motor seizures (HP:0011153)2.35069961
42Epidermoid cyst (HP:0200040)2.28873554
43Attenuation of retinal blood vessels (HP:0007843)2.26989606
44Hypokalemic alkalosis (HP:0001949)2.20207893
45Dialeptic seizures (HP:0011146)2.18143668
46Severe visual impairment (HP:0001141)2.16781371
47Lissencephaly (HP:0001339)2.16776932
48Dysmetric saccades (HP:0000641)2.16767931
49Focal seizures (HP:0007359)2.16490112
50Absence seizures (HP:0002121)2.15927287
51Intellectual disability, severe (HP:0010864)2.14755962
52Clubbing of toes (HP:0100760)2.13065155
53Tubulointerstitial fibrosis (HP:0005576)2.12596067
54Cystic liver disease (HP:0006706)2.11771087
55Tubulointerstitial abnormality (HP:0001969)2.10928819
56Gait imbalance (HP:0002141)2.10633595
57Hypothermia (HP:0002045)2.10409540
58Dysdiadochokinesis (HP:0002075)2.10039899
59Abnormality of the hepatic vasculature (HP:0006707)2.01655783
60Hypoproteinemia (HP:0003075)1.99807851
61Abnormality of the ileum (HP:0001549)1.98915993
62Neonatal respiratory distress (HP:0002643)1.98735717
63Macroglossia (HP:0000158)1.96836499
64Blue irides (HP:0000635)1.94948732
65Progressive microcephaly (HP:0000253)1.94766313
66Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94349407
67Meckel diverticulum (HP:0002245)1.94003869
68Metabolic alkalosis (HP:0200114)1.93606828
69Astigmatism (HP:0000483)1.93374305
70Inappropriate behavior (HP:0000719)1.92436456
71Tubular atrophy (HP:0000092)1.92234640
72Retinitis pigmentosa (HP:0000510)1.90532920
73Hypochromic microcytic anemia (HP:0004840)1.89576707
74Postaxial foot polydactyly (HP:0001830)1.88073191
75Genital tract atresia (HP:0001827)1.86858867
76Congenital primary aphakia (HP:0007707)1.86699202
77Abnormality of incisor morphology (HP:0011063)1.83913787
78Neoplasm of the adrenal cortex (HP:0100641)1.83269490
79Abolished electroretinogram (ERG) (HP:0000550)1.83188311
80Hypoalbuminemia (HP:0003073)1.82287949
81Abnormal albumin level (HP:0012116)1.82287949
82Abnormality of the metopic suture (HP:0005556)1.81067015
83Abnormality of male internal genitalia (HP:0000022)1.80716356
84Abnormality of macular pigmentation (HP:0008002)1.79688739
85Volvulus (HP:0002580)1.79491499
86Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79433978
87Postural instability (HP:0002172)1.79243354
88Pachygyria (HP:0001302)1.78699391
89Congenital hepatic fibrosis (HP:0002612)1.77146597
90Type II lissencephaly (HP:0007260)1.77032708
91Vaginal atresia (HP:0000148)1.75760001
92Polyuria (HP:0000103)1.75493435
93Postaxial hand polydactyly (HP:0001162)1.74614842
94Ketoacidosis (HP:0001993)1.74171310
95Impaired smooth pursuit (HP:0007772)1.73899915
96Abnormality of chloride homeostasis (HP:0011422)1.73703086
97Long nose (HP:0003189)1.71679796
98Median cleft lip (HP:0000161)1.70875593
99Renal cortical cysts (HP:0000803)1.70629410
100Oculomotor apraxia (HP:0000657)1.70081469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB16.66106463
2NEK24.92467518
3CAMKK24.72895023
4FRK4.21873981
5TAF13.57364786
6CAMK1D3.33663836
7CASK2.85499064
8CAMK1G2.45267500
9NUAK12.27176607
10MAPK132.00836599
11VRK21.98875487
12MAP3K41.78121801
13MARK11.61352344
14STK38L1.59094188
15CAMKK11.57502518
16GRK11.57367121
17TNIK1.51553864
18MAP2K71.49610570
19WNK41.48920748
20MAP3K71.36420920
21CDK191.32269618
22OXSR11.29677168
23VRK11.24038245
24MAP4K21.14846131
25WNK31.02421409
26CAMK11.00987145
27TAOK30.99100484
28BMPR1B0.97677227
29GRK50.96082000
30MAPKAPK50.95567372
31PINK10.94146560
32DYRK20.91703677
33TXK0.91245714
34CSNK1G10.91076157
35ADRBK20.88959416
36DYRK1A0.88570724
37BRSK20.88519766
38PIK3CA0.86585585
39CSNK1G30.86400688
40AKT30.84627654
41PRKCE0.84057504
42ACVR1B0.82529074
43CSNK1G20.80161264
44INSRR0.79274195
45CHUK0.78873515
46SIK20.70962000
47CSNK1A1L0.70560312
48SMG10.69852583
49PRKAA20.68565368
50PRKCH0.66946951
51SGK20.65797511
52BCR0.64819725
53TNK20.64635659
54CAMK40.61725714
55PTK2B0.61298882
56PRKCG0.60524825
57PDK20.58786066
58MKNK20.58203790
59PIK3CG0.56342456
60NTRK30.55098089
61PHKG10.54272900
62PHKG20.54272900
63PAK30.53247946
64DAPK20.52931053
65ADRBK10.52903756
66WNK10.48536512
67MATK0.47277435
68DAPK10.47155037
69ERBB30.45939114
70PRKG10.40965535
71TESK20.40537244
72EIF2AK20.36946383
73CDK30.35342584
74SGK10.35178227
75MAP2K40.33951030
76TRPM70.33621916
77PKN10.33346698
78PLK30.33219441
79PLK20.33175941
80HIPK20.32715862
81CSNK1A10.32242698
82DYRK30.30275740
83CSNK1D0.29507631
84ERBB20.29369410
85PRKACA0.28579741
86MAP3K60.27417035
87MAP2K60.26294687
88PRKCA0.25453042
89ERN10.25344699
90ZAK0.23972746
91PLK40.23748503
92STK30.23544440
93CAMK2A0.23230543
94PRKCZ0.22578239
95SYK0.21908925
96RPS6KB20.21030169
97WEE10.20819717
98STK380.20502878
99MKNK10.20492994
100PRKAA10.20345243

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.03353387
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.72857625
3Phototransduction_Homo sapiens_hsa047442.50542043
4Propanoate metabolism_Homo sapiens_hsa006402.48887433
5Caffeine metabolism_Homo sapiens_hsa002322.43457806
6Butanoate metabolism_Homo sapiens_hsa006502.42524195
7Nicotine addiction_Homo sapiens_hsa050332.27788500
8Tryptophan metabolism_Homo sapiens_hsa003802.17008379
9Taste transduction_Homo sapiens_hsa047422.14431178
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12838943
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.09730578
12Homologous recombination_Homo sapiens_hsa034402.09461744
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.06295582
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04415088
15Selenocompound metabolism_Homo sapiens_hsa004502.02059525
16Nitrogen metabolism_Homo sapiens_hsa009102.00547375
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.90768974
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86716235
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83195561
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83116446
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83058274
22Renin-angiotensin system_Homo sapiens_hsa046141.73364894
23Linoleic acid metabolism_Homo sapiens_hsa005911.71780900
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.70703091
25Sulfur metabolism_Homo sapiens_hsa009201.65437431
26Basal transcription factors_Homo sapiens_hsa030221.58476307
27Retinol metabolism_Homo sapiens_hsa008301.50990459
28Glutamatergic synapse_Homo sapiens_hsa047241.45506467
29Chemical carcinogenesis_Homo sapiens_hsa052041.41342459
30Olfactory transduction_Homo sapiens_hsa047401.39154765
31Ether lipid metabolism_Homo sapiens_hsa005651.39113864
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38619125
33Histidine metabolism_Homo sapiens_hsa003401.35670991
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34131149
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30760501
36Non-homologous end-joining_Homo sapiens_hsa034501.27128817
37Fanconi anemia pathway_Homo sapiens_hsa034601.26033799
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25483554
39Insulin secretion_Homo sapiens_hsa049111.22612812
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.19871283
41beta-Alanine metabolism_Homo sapiens_hsa004101.18604946
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10673101
43Pyruvate metabolism_Homo sapiens_hsa006201.10669212
44Glycerolipid metabolism_Homo sapiens_hsa005611.10080783
45Cocaine addiction_Homo sapiens_hsa050301.10045245
46Peroxisome_Homo sapiens_hsa041461.06850542
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06065647
48ABC transporters_Homo sapiens_hsa020101.02925360
49Circadian entrainment_Homo sapiens_hsa047131.00945215
50Fatty acid degradation_Homo sapiens_hsa000710.97354425
51Morphine addiction_Homo sapiens_hsa050320.94224631
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91320201
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.91094826
54Circadian rhythm_Homo sapiens_hsa047100.86272288
55One carbon pool by folate_Homo sapiens_hsa006700.82200490
56Dopaminergic synapse_Homo sapiens_hsa047280.80253180
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80200114
58GABAergic synapse_Homo sapiens_hsa047270.76600714
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76273097
60Calcium signaling pathway_Homo sapiens_hsa040200.72745976
61Arginine and proline metabolism_Homo sapiens_hsa003300.71411642
62Long-term depression_Homo sapiens_hsa047300.68411048
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67241465
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66370365
65Fat digestion and absorption_Homo sapiens_hsa049750.65888316
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.64225568
67Starch and sucrose metabolism_Homo sapiens_hsa005000.64196283
68Axon guidance_Homo sapiens_hsa043600.63550541
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62305708
70Glutathione metabolism_Homo sapiens_hsa004800.61861057
71Serotonergic synapse_Homo sapiens_hsa047260.60686971
72Ovarian steroidogenesis_Homo sapiens_hsa049130.60162135
73Steroid biosynthesis_Homo sapiens_hsa001000.59882903
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59647602
75Amphetamine addiction_Homo sapiens_hsa050310.57461497
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52353905
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.51231073
78Metabolic pathways_Homo sapiens_hsa011000.51105981
79Base excision repair_Homo sapiens_hsa034100.50685693
80Type II diabetes mellitus_Homo sapiens_hsa049300.48927374
81Salivary secretion_Homo sapiens_hsa049700.47710185
82cAMP signaling pathway_Homo sapiens_hsa040240.47686690
83Regulation of autophagy_Homo sapiens_hsa041400.46994901
84Arachidonic acid metabolism_Homo sapiens_hsa005900.42742844
85Pancreatic secretion_Homo sapiens_hsa049720.42104320
86Lysine degradation_Homo sapiens_hsa003100.41044017
87Renin secretion_Homo sapiens_hsa049240.39742414
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39594569
89Glucagon signaling pathway_Homo sapiens_hsa049220.37149348
90Cholinergic synapse_Homo sapiens_hsa047250.37140179
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36693246
92Oxytocin signaling pathway_Homo sapiens_hsa049210.32455458
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29430418
94Protein export_Homo sapiens_hsa030600.27835227
95Complement and coagulation cascades_Homo sapiens_hsa046100.27460231
96Hedgehog signaling pathway_Homo sapiens_hsa043400.26316855
97Nucleotide excision repair_Homo sapiens_hsa034200.25690370
98Folate biosynthesis_Homo sapiens_hsa007900.24769448
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23031770
100RNA degradation_Homo sapiens_hsa030180.22648655

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