ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	phospholipid efflux (GO:0033700)	9.60529402
2	high-density lipoprotein particle remodeling (GO:0034375)	9.27101995
3	regulation of triglyceride catabolic process (GO:0010896)	8.71225069
4	reverse cholesterol transport (GO:0043691)	8.08258421
5	plasma lipoprotein particle assembly (GO:0034377)	7.42216690
6	very-low-density lipoprotein particle assembly (GO:0034379)	6.80730457
7	protein-lipid complex assembly (GO:0065005)	6.47325433
8	regulation of cholesterol esterification (GO:0010872)	6.28875693
9	cholesterol efflux (GO:0033344)	5.83479671
10	protein-lipid complex remodeling (GO:0034368)	5.63974232
11	macromolecular complex remodeling (GO:0034367)	5.63974232
12	plasma lipoprotein particle remodeling (GO:0034369)	5.63974232
13	negative regulation of lipase activity (GO:0060192)	5.14814037
14	DNA damage response, detection of DNA damage (GO:0042769)	5.02699421
15	transepithelial transport (GO:0070633)	4.72518638
16	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.72332118
17	lipoprotein transport (GO:0042953)	4.55190779
18	negative regulation of sterol transport (GO:0032372)	4.48053282
19	negative regulation of cholesterol transport (GO:0032375)	4.48053282
20	water-soluble vitamin biosynthetic process (GO:0042364)	4.41284334
21	negative regulation of fatty acid biosynthetic process (GO:0045717)	4.23147028
22	plasma lipoprotein particle organization (GO:0071827)	4.19837555
23	ovulation from ovarian follicle (GO:0001542)	4.14746347
24	regulation of lipoprotein metabolic process (GO:0050746)	4.06977494
25	DNA double-strand break processing (GO:0000729)	3.99804352
26	plasma lipoprotein particle clearance (GO:0034381)	3.90539229
27	protein-lipid complex subunit organization (GO:0071825)	3.87616817
28	removal of superoxide radicals (GO:0019430)	3.80106634
29	cellular response to superoxide (GO:0071451)	3.80106634
30	cellular response to oxygen radical (GO:0071450)	3.80106634
31	polyol transport (GO:0015791)	3.77759664
32	glial cell proliferation (GO:0014009)	3.69456852
33	cellular response to nitric oxide (GO:0071732)	3.68381261
34	negative regulation of receptor-mediated endocytosis (GO:0048261)	3.55770727
35	cellular response to zinc ion (GO:0071294)	3.52880121
36	positive regulation of lipoprotein lipase activity (GO:0051006)	3.45111492
37	positive regulation of triglyceride lipase activity (GO:0061365)	3.45111492
38	response to phenylpropanoid (GO:0080184)	3.40941028
39	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.37589597
40	centriole replication (GO:0007099)	3.22995962
41	regulation of lipoprotein particle clearance (GO:0010984)	3.22490947
42	triglyceride homeostasis (GO:0070328)	3.21176949
43	acylglycerol homeostasis (GO:0055090)	3.21176949
44	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.20648165
45	response to hydroperoxide (GO:0033194)	3.19853836
46	negative regulation of DNA recombination (GO:0045910)	3.15898636
47	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.15440156
48	regulation of translation, ncRNA-mediated (GO:0045974)	3.15440156
49	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.15440156
50	replication fork processing (GO:0031297)	3.11997257
51	regulation of triglyceride metabolic process (GO:0090207)	3.11822085
52	DNA ligation (GO:0006266)	3.06433673
53	C4-dicarboxylate transport (GO:0015740)	3.05393977
54	respiratory chain complex IV assembly (GO:0008535)	3.03370597
55	cholesterol transport (GO:0030301)	3.02307566
56	sterol transport (GO:0015918)	3.02307566
57	protein carboxylation (GO:0018214)	2.94600689
58	peptidyl-glutamic acid carboxylation (GO:0017187)	2.94600689
59	positive regulation of glycoprotein metabolic process (GO:1903020)	2.94036539
60	vitamin A metabolic process (GO:0006776)	2.92303567
61	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.83286058
62	phototransduction, visible light (GO:0007603)	2.82308136
63	regulation of protein glycosylation (GO:0060049)	2.82008194
64	response to superoxide (GO:0000303)	2.79830752
65	cellular response to reactive nitrogen species (GO:1902170)	2.78716981
66	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.78562467
67	regulation of mitotic spindle checkpoint (GO:1903504)	2.78562467
68	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.77085994
69	microtubule anchoring (GO:0034453)	2.77030609
70	mechanosensory behavior (GO:0007638)	2.75153112
71	negative regulation of lipid catabolic process (GO:0050995)	2.72597134
72	L-ascorbic acid metabolic process (GO:0019852)	2.71322629
73	cytochrome complex assembly (GO:0017004)	2.71071718
74	homocysteine metabolic process (GO:0050667)	2.70300711
75	DNA replication-dependent nucleosome organization (GO:0034723)	2.70265818
76	DNA replication-dependent nucleosome assembly (GO:0006335)	2.70265818
77	sulfation (GO:0051923)	2.70094391
78	regulation of lipoprotein lipase activity (GO:0051004)	2.64856374
79	lipoprotein metabolic process (GO:0042157)	2.62272778
80	double-strand break repair via nonhomologous end joining (GO:0006303)	2.62027246
81	non-recombinational repair (GO:0000726)	2.62027246
82	telomere maintenance via telomerase (GO:0007004)	2.60893800
83	detection of visible light (GO:0009584)	2.59533539
84	neutral lipid catabolic process (GO:0046461)	2.59156888
85	acylglycerol catabolic process (GO:0046464)	2.59156888
86	glutathione derivative biosynthetic process (GO:1901687)	2.59016504
87	glutathione derivative metabolic process (GO:1901685)	2.59016504
88	chromatin remodeling at centromere (GO:0031055)	2.57024236
89	sperm capacitation (GO:0048240)	2.55895479
90	glutamine metabolic process (GO:0006541)	2.55323819
91	retinal cone cell development (GO:0046549)	2.55138897
92	presynaptic membrane assembly (GO:0097105)	2.52013555
93	response to oxygen radical (GO:0000305)	2.51745509
94	cholesterol homeostasis (GO:0042632)	2.51568314
95	retinoid metabolic process (GO:0001523)	2.48583876
96	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.47243538
97	phototransduction (GO:0007602)	2.47149311
98	sulfate transmembrane transport (GO:1902358)	2.46903570
99	sterol homeostasis (GO:0055092)	2.46284563
100	anterograde synaptic vesicle transport (GO:0048490)	2.43763470

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.53787013
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.39495240
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.06555573
4	VDR_22108803_ChIP-Seq_LS180_Human	2.82071362
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.63373652
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.48306247
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.46927524
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.45872629
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.40924389
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.30254397
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.26208734
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.17726486
13	P300_19829295_ChIP-Seq_ESCs_Human	2.16576810
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.09295967
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.08567170
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.06470200
17	E2F7_22180533_ChIP-Seq_HELA_Human	2.00166304
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99248930
19	FUS_26573619_Chip-Seq_HEK293_Human	1.96821948
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.93869610
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.91765767
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79920204
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.76409367
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.75383157
25	EWS_26573619_Chip-Seq_HEK293_Human	1.75242288
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.68928826
27	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.65164855
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.62605138
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.61663853
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.59774143
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.59006423
32	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.58060819
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.56153778
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55479820
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54737958
36	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.53583853
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.52970613
38	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.52546058
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.50976106
40	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.50131861
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.49648611
42	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.43648371
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41146299
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40072880
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40072880
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39779469
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39309585
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39223003
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35979362
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.35536345
51	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.34317086
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33439258
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32562592
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32311813
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28034358
56	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.24886167
57	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.23367550
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23323048
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.23323048
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22907823
61	STAT3_23295773_ChIP-Seq_U87_Human	1.22533132
62	AR_25329375_ChIP-Seq_VCAP_Human	1.21599585
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20280868
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.16894381
65	TP53_18474530_ChIP-ChIP_U2OS_Human	1.14825982
66	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14706813
67	TCF4_23295773_ChIP-Seq_U87_Human	1.14665728
68	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.14508091
69	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.12772914
70	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.12151089
71	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.12121262
72	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11329534
73	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.10957968
74	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10154748
75	ER_23166858_ChIP-Seq_MCF-7_Human	1.09911223
76	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.09357002
77	AR_21909140_ChIP-Seq_LNCAP_Human	1.09192098
78	P300_18555785_Chip-Seq_ESCs_Mouse	1.08827948
79	CDX2_22108803_ChIP-Seq_LS180_Human	1.08243790
80	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.08187370
81	AR_21572438_ChIP-Seq_LNCaP_Human	1.07709050
82	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.07402649
83	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.06805242
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05668283
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05668283
86	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05470120
87	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.05371100
88	EZH2_22144423_ChIP-Seq_EOC_Human	1.04785962
89	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04489084
90	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.02826922
91	JUN_21703547_ChIP-Seq_K562_Human	1.02617916
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02094635
93	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01654565
94	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01461364
95	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01461364
96	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.98550907
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.97675979
98	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.97296290
99	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.97241517
100	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.95826150

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009840_abnormal_foam_cell	7.78980612
2	MP0004270_analgesia	4.28285622
3	MP0005360_urolithiasis	4.06671243
4	MP0001188_hyperpigmentation	3.59854530
5	MP0003878_abnormal_ear_physiology	3.26723320
6	MP0005377_hearing/vestibular/ear_phenot	3.26723320
7	MP0003941_abnormal_skin_development	2.65383385
8	MP0002254_reproductive_system_inflammat	2.27898795
9	MP0003718_maternal_effect	2.26342797
10	MP0006072_abnormal_retinal_apoptosis	2.24480515
11	MP0000569_abnormal_digit_pigmentation	2.23989619
12	MP0008877_abnormal_DNA_methylation	2.07309110
13	MP0002734_abnormal_mechanical_nocicepti	2.05916137
14	MP0008058_abnormal_DNA_repair	1.98124529
15	MP0001485_abnormal_pinna_reflex	1.97813065
16	MP0010329_abnormal_lipoprotein_level	1.95792667
17	MP0004145_abnormal_muscle_electrophysio	1.95136626
18	MP0004019_abnormal_vitamin_homeostasis	1.93577492
19	MP0003136_yellow_coat_color	1.92580845
20	MP0005551_abnormal_eye_electrophysiolog	1.88599459
21	MP0002938_white_spotting	1.85494590
22	MP0005367_renal/urinary_system_phenotyp	1.70500819
23	MP0000516_abnormal_urinary_system	1.70500819
24	MP0010094_abnormal_chromosome_stability	1.60840745
25	MP0001293_anophthalmia	1.59731483
26	MP0004142_abnormal_muscle_tone	1.58034366
27	MP0003567_abnormal_fetal_cardiomyocyte	1.48134336
28	MP0003880_abnormal_central_pattern	1.47085706
29	MP0002876_abnormal_thyroid_physiology	1.41652981
30	MP0001529_abnormal_vocalization	1.40138742
31	MP0003121_genomic_imprinting	1.38427580
32	MP0004043_abnormal_pH_regulation	1.36451355
33	MP0005171_absent_coat_pigmentation	1.36174082
34	MP0001486_abnormal_startle_reflex	1.36088052
35	MP0002090_abnormal_vision	1.34382059
36	MP0000372_irregular_coat_pigmentation	1.33362060
37	MP0001177_atelectasis	1.32928131
38	MP0010352_gastrointestinal_tract_polyps	1.31002974
39	MP0005332_abnormal_amino_acid	1.30560458
40	MP0005253_abnormal_eye_physiology	1.26926936
41	MP0003111_abnormal_nucleus_morphology	1.23442195
42	MP0001299_abnormal_eye_distance/	1.22707054
43	MP0003122_maternal_imprinting	1.21024933
44	MP0002751_abnormal_autonomic_nervous	1.20838223
45	MP0004147_increased_porphyrin_level	1.20243776
46	MP0005174_abnormal_tail_pigmentation	1.11452262
47	MP0003890_abnormal_embryonic-extraembry	1.10438526
48	MP0002295_abnormal_pulmonary_circulatio	1.09908909
49	MP0009046_muscle_twitch	1.09327307
50	MP0002557_abnormal_social/conspecific_i	1.08212701
51	MP0002822_catalepsy	1.05400042
52	MP0003123_paternal_imprinting	1.05081931
53	MP0005395_other_phenotype	1.02053249
54	MP0003119_abnormal_digestive_system	1.00084389
55	MP0009703_decreased_birth_body	0.99315877
56	MP0002736_abnormal_nociception_after	0.98951160
57	MP0003787_abnormal_imprinting	0.97883463
58	MP0002184_abnormal_innervation	0.97397121
59	MP0008057_abnormal_DNA_replication	0.96620512
60	MP0003186_abnormal_redox_activity	0.95175524
61	MP0009697_abnormal_copulation	0.93354405
62	MP0001324_abnormal_eye_pigmentation	0.91604733
63	MP0003937_abnormal_limbs/digits/tail_de	0.88410690
64	MP0002272_abnormal_nervous_system	0.86186876
65	MP0002837_dystrophic_cardiac_calcinosis	0.85120039
66	MP0005248_abnormal_Harderian_gland	0.84614014
67	MP0000778_abnormal_nervous_system	0.82832146
68	MP0001666_abnormal_nutrient_absorption	0.82790363
69	MP0001286_abnormal_eye_development	0.82244356
70	MP0000427_abnormal_hair_cycle	0.81736218
71	MP0005075_abnormal_melanosome_morpholog	0.78913329
72	MP0003011_delayed_dark_adaptation	0.78373272
73	MP0006276_abnormal_autonomic_nervous	0.77078666
74	MP0004215_abnormal_myocardial_fiber	0.76813718
75	MP0009672_abnormal_birth_weight	0.76558422
76	MP0003195_calcinosis	0.76444254
77	MP0000647_abnormal_sebaceous_gland	0.76250289
78	MP0003693_abnormal_embryo_hatching	0.75985747
79	MP0005195_abnormal_posterior_eye	0.74778593
80	MP0002095_abnormal_skin_pigmentation	0.73888485
81	MP0002067_abnormal_sensory_capabilities	0.72412200
82	MP0004957_abnormal_blastocyst_morpholog	0.72036081
83	MP0002102_abnormal_ear_morphology	0.71716695
84	MP0000631_abnormal_neuroendocrine_gland	0.71379005
85	MP0001968_abnormal_touch/_nociception	0.70672311
86	MP0005391_vision/eye_phenotype	0.69236124
87	MP0000579_abnormal_nail_morphology	0.67737731
88	MP0008007_abnormal_cellular_replicative	0.67501635
89	MP0005645_abnormal_hypothalamus_physiol	0.65983235
90	MP0004133_heterotaxia	0.65275504
91	MP0002697_abnormal_eye_size	0.61588420
92	MP0002752_abnormal_somatic_nervous	0.61390002
93	MP0008569_lethality_at_weaning	0.61128446
94	MP0000566_synostosis	0.59509357
95	MP0006036_abnormal_mitochondrial_physio	0.56418844
96	MP0005636_abnormal_mineral_homeostasis	0.56398515
97	MP0002069_abnormal_eating/drinking_beha	0.54663563
98	MP0003786_premature_aging	0.53902743
99	MP0005408_hypopigmentation	0.53313022
100	MP0005187_abnormal_penis_morphology	0.52996001

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypobetalipoproteinemia (HP:0003563)	8.61470562
2	Hyperlipoproteinemia (HP:0010980)	5.42350669
3	Hypolipoproteinemia (HP:0010981)	5.36464685
4	Hyperglycinemia (HP:0002154)	5.21946945
5	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.10832658
6	Abnormality of the labia minora (HP:0012880)	4.01552387
7	Malnutrition (HP:0004395)	4.00291532
8	Abnormality of pyrimidine metabolism (HP:0004353)	3.98726541
9	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.51518278
10	Colon cancer (HP:0003003)	3.42062318
11	Abnormality of glycine metabolism (HP:0010895)	3.28052485
12	Abnormality of serine family amino acid metabolism (HP:0010894)	3.28052485
13	Chromsome breakage (HP:0040012)	3.23839946
14	Abnormality of chromosome stability (HP:0003220)	3.12444598
15	Hypomagnesemia (HP:0002917)	3.00780771
16	Abnormality of serum amino acid levels (HP:0003112)	2.92005922
17	Type 2 muscle fiber atrophy (HP:0003554)	2.91074505
18	Hyperglycinuria (HP:0003108)	2.87034872
19	Meckel diverticulum (HP:0002245)	2.79887245
20	Abolished electroretinogram (ERG) (HP:0000550)	2.77919380
21	Pendular nystagmus (HP:0012043)	2.76827717
22	Proximal tubulopathy (HP:0000114)	2.75449539
23	Abnormality of the ileum (HP:0001549)	2.74138097
24	Nausea (HP:0002018)	2.67472905
25	Abnormality of methionine metabolism (HP:0010901)	2.65046386
26	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.60125815
27	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.56074920
28	Methylmalonic acidemia (HP:0002912)	2.54899940
29	Hepatoblastoma (HP:0002884)	2.51248485
30	Volvulus (HP:0002580)	2.46054936
31	Pigmentary retinal degeneration (HP:0001146)	2.42154183
32	Abnormality of the preputium (HP:0100587)	2.40737867
33	Bicornuate uterus (HP:0000813)	2.39650927
34	Hypoalphalipoproteinemia (HP:0003233)	2.35562926
35	Neoplasm of the adrenal cortex (HP:0100641)	2.30226156
36	Intestinal atresia (HP:0011100)	2.27747378
37	Muscle fiber atrophy (HP:0100295)	2.25775993
38	Methylmalonic aciduria (HP:0012120)	2.24963933
39	Abnormality of vitamin B metabolism (HP:0004340)	2.24433493
40	Dyschromatopsia (HP:0007641)	2.24300574
41	Tetany (HP:0001281)	2.23279642
42	Spontaneous abortion (HP:0005268)	2.20466227
43	Neoplasm of the oral cavity (HP:0100649)	2.18975998
44	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.18739972
45	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.17662789
46	Abnormality of magnesium homeostasis (HP:0004921)	2.15985084
47	Neoplasm of the adrenal gland (HP:0100631)	2.09902221
48	Decreased muscle mass (HP:0003199)	2.08278749
49	Stenosis of the external auditory canal (HP:0000402)	2.07662902
50	Severe Myopia (HP:0011003)	2.06197040
51	Small intestinal stenosis (HP:0012848)	2.05217585
52	Duodenal stenosis (HP:0100867)	2.05217585
53	Oligodactyly (hands) (HP:0001180)	2.01829711
54	Chronic hepatic failure (HP:0100626)	1.99885889
55	Impulsivity (HP:0100710)	1.99652312
56	Papillary thyroid carcinoma (HP:0002895)	1.99366268
57	Tubulointerstitial nephritis (HP:0001970)	1.97071514
58	Nephroblastoma (Wilms tumor) (HP:0002667)	1.96519373
59	Truncal obesity (HP:0001956)	1.95464206
60	Abnormal lung lobation (HP:0002101)	1.94384919
61	Pancreatic islet-cell hyperplasia (HP:0004510)	1.94150579
62	Genital tract atresia (HP:0001827)	1.94096572
63	Abnormal hair whorl (HP:0010721)	1.94014896
64	Delayed CNS myelination (HP:0002188)	1.92259406
65	Stomach cancer (HP:0012126)	1.91767985
66	Abnormality of the duodenum (HP:0002246)	1.91130582
67	Bifid tongue (HP:0010297)	1.90248354
68	Pancreatic cysts (HP:0001737)	1.87928924
69	Septo-optic dysplasia (HP:0100842)	1.86902004
70	Choroideremia (HP:0001139)	1.85370859
71	Absent radius (HP:0003974)	1.84698179
72	Fair hair (HP:0002286)	1.83665443
73	Abnormality of the carotid arteries (HP:0005344)	1.83238303
74	Vaginal atresia (HP:0000148)	1.82830161
75	True hermaphroditism (HP:0010459)	1.80476858
76	Embryonal renal neoplasm (HP:0011794)	1.78515331
77	Abnormality of the astrocytes (HP:0100707)	1.76909163
78	Astrocytoma (HP:0009592)	1.76909163
79	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.75185842
80	Congenital sensorineural hearing impairment (HP:0008527)	1.74291503
81	Hyperventilation (HP:0002883)	1.72670143
82	Absent forearm bone (HP:0003953)	1.72013906
83	Aplasia involving forearm bones (HP:0009822)	1.72013906
84	Birth length less than 3rd percentile (HP:0003561)	1.70731848
85	Abnormality of vitamin metabolism (HP:0100508)	1.70278927
86	Abnormality of midbrain morphology (HP:0002418)	1.70192117
87	Molar tooth sign on MRI (HP:0002419)	1.70192117
88	Absent hair (HP:0002298)	1.69486775
89	Clubbing of toes (HP:0100760)	1.69220718
90	Hypothermia (HP:0002045)	1.68323647
91	Vacuolated lymphocytes (HP:0001922)	1.67626398
92	Pancreatic fibrosis (HP:0100732)	1.65758779
93	Epidermoid cyst (HP:0200040)	1.65087938
94	Drooling (HP:0002307)	1.63977871
95	Abnormality of macular pigmentation (HP:0008002)	1.63837808
96	Joint hemorrhage (HP:0005261)	1.63501905
97	Acute encephalopathy (HP:0006846)	1.62642914
98	Fatigable weakness (HP:0003473)	1.62554976
99	Abnormality of the neuromuscular junction (HP:0003398)	1.62554976
100	Absent eyebrow (HP:0002223)	1.62344701

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MUSK	5.95523223
2	PIK3CG	5.38884401
3	WNK3	4.01536398
4	MKNK2	3.07519318
5	TNIK	2.89896615
6	ACVR1B	2.85521824
7	MAP3K4	2.82487569
8	TRIM28	2.63277985
9	CASK	2.55980767
10	FRK	2.51872281
11	BUB1	2.16020876
12	MAP2K7	2.15166212
13	MKNK1	2.10569797
14	NEK1	2.07818433
15	BMPR1B	2.04901857
16	BCKDK	1.95788268
17	MAP3K6	1.92945792
18	TSSK6	1.63549109
19	NUAK1	1.55778038
20	FGFR2	1.54634940
21	PLK4	1.54572603
22	GRK1	1.51703961
23	MAP4K2	1.49068577
24	NME1	1.38911185
25	PBK	1.37079007
26	EPHA4	1.36513681
27	ZAK	1.26200491
28	CDC7	1.23123954
29	NLK	1.15585145
30	TESK2	1.13761648
31	CSNK1G2	1.11581135
32	PLK3	1.08803054
33	TTK	1.06465808
34	MST4	1.02952986
35	SRPK1	1.01320802
36	BRSK2	0.99340138
37	TAF1	0.98401589
38	MAP2K4	0.96970773
39	ADRBK2	0.92994125
40	CSNK1G1	0.92614500
41	AKT3	0.91105236
42	PLK1	0.81862584
43	PRKCG	0.78885424
44	FGFR1	0.77985400
45	PRKCE	0.75882561
46	WEE1	0.73640482
47	PAK3	0.72831822
48	DYRK2	0.72777335
49	VRK1	0.72120239
50	MARK1	0.71645174
51	ERBB3	0.70938261
52	DYRK3	0.70498932
53	EIF2AK3	0.67021753
54	CSNK1A1L	0.62603389
55	CSNK1G3	0.61940904
56	TGFBR1	0.61936979
57	BCR	0.58520021
58	STK38L	0.51312267
59	UHMK1	0.50938523
60	STK39	0.49934573
61	MAPK13	0.49264783
62	PDK2	0.48900778
63	VRK2	0.47101403
64	PLK2	0.44983525
65	OXSR1	0.44747967
66	SGK2	0.42438796
67	ATM	0.39580247
68	ERBB4	0.39451177
69	ALK	0.37177490
70	PRKACB	0.37166255
71	INSRR	0.36148795
72	SGK494	0.35856694
73	SGK223	0.35856694
74	ATR	0.35853798
75	TIE1	0.35540999
76	EPHA3	0.33766716
77	FGR	0.31965660
78	CHEK1	0.31778918
79	MAP3K5	0.31761666
80	CDK3	0.31501135
81	FER	0.30458040
82	CDK19	0.29931478
83	MARK3	0.27956752
84	AURKB	0.27644415
85	CSNK1D	0.26951690
86	EIF2AK2	0.25758559
87	PRKCB	0.25529388
88	PRKDC	0.25245306
89	PINK1	0.24680919
90	CSNK1E	0.24519667
91	MAP3K12	0.24446186
92	YES1	0.24123151
93	CAMK2A	0.23692837
94	CSNK2A1	0.21640521
95	MYLK	0.21424050
96	RPS6KA4	0.21415535
97	CHEK2	0.21300511
98	OBSCN	0.20905410
99	PTK2B	0.20517900
100	CDK1	0.20459838

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin digestion and absorption_Homo sapiens_hsa04977	5.00778436
2	Selenocompound metabolism_Homo sapiens_hsa00450	2.50529403
3	Fat digestion and absorption_Homo sapiens_hsa04975	2.46174417
4	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.26294363
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.25450528
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.23970624
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.18476718
8	Galactose metabolism_Homo sapiens_hsa00052	2.16612513
9	Propanoate metabolism_Homo sapiens_hsa00640	2.15364954
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.13776187
11	Mineral absorption_Homo sapiens_hsa04978	2.07821640
12	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.07210215
13	Nicotine addiction_Homo sapiens_hsa05033	2.00688412
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.98565206
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.94891721
16	Fatty acid elongation_Homo sapiens_hsa00062	1.83575185
17	Mismatch repair_Homo sapiens_hsa03430	1.80183441
18	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.72564872
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.71118736
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.70731635
21	Homologous recombination_Homo sapiens_hsa03440	1.64969479
22	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.61107198
23	Proteasome_Homo sapiens_hsa03050	1.60473221
24	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.58178949
25	Basal transcription factors_Homo sapiens_hsa03022	1.56344773
26	One carbon pool by folate_Homo sapiens_hsa00670	1.51365561
27	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.50267032
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.45775643
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.43554035
30	RNA polymerase_Homo sapiens_hsa03020	1.43083750
31	Protein export_Homo sapiens_hsa03060	1.41849000
32	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.41491776
33	DNA replication_Homo sapiens_hsa03030	1.38439422
34	Oxidative phosphorylation_Homo sapiens_hsa00190	1.34446925
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32217134
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.27103605
37	Glutathione metabolism_Homo sapiens_hsa00480	1.25532421
38	Parkinsons disease_Homo sapiens_hsa05012	1.24023143
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.23359211
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.22090930
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.13009982
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.10446326
43	Butanoate metabolism_Homo sapiens_hsa00650	1.09721634
44	Fatty acid degradation_Homo sapiens_hsa00071	1.07707817
45	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.06270987
46	RNA degradation_Homo sapiens_hsa03018	1.05513623
47	Huntingtons disease_Homo sapiens_hsa05016	1.01183246
48	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.00576663
49	Arginine and proline metabolism_Homo sapiens_hsa00330	0.98966339
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.98529064
51	Purine metabolism_Homo sapiens_hsa00230	0.97902234
52	Phototransduction_Homo sapiens_hsa04744	0.97028018
53	RNA transport_Homo sapiens_hsa03013	0.96717055
54	Retinol metabolism_Homo sapiens_hsa00830	0.95856161
55	Carbon metabolism_Homo sapiens_hsa01200	0.94032943
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.92959108
57	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.92788714
58	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.91275279
59	Complement and coagulation cascades_Homo sapiens_hsa04610	0.85610940
60	PPAR signaling pathway_Homo sapiens_hsa03320	0.84897193
61	Metabolic pathways_Homo sapiens_hsa01100	0.73019982
62	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.68615494
63	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.66206438
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65226666
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.64658879
66	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.64204129
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.63318257
68	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.61397774
69	Taste transduction_Homo sapiens_hsa04742	0.61068062
70	Cell cycle_Homo sapiens_hsa04110	0.60829342
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60739843
72	Spliceosome_Homo sapiens_hsa03040	0.60680136
73	Alzheimers disease_Homo sapiens_hsa05010	0.57098663
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57082907
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56598279
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.56030569
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55818025
78	Histidine metabolism_Homo sapiens_hsa00340	0.55654966
79	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.54264400
80	Peroxisome_Homo sapiens_hsa04146	0.53796346
81	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53347052
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.50919095
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.49836658
84	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.48875689
85	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.47992771
86	Nitrogen metabolism_Homo sapiens_hsa00910	0.47030158
87	p53 signaling pathway_Homo sapiens_hsa04115	0.45818483
88	Morphine addiction_Homo sapiens_hsa05032	0.44854026
89	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.44747258
90	Tight junction_Homo sapiens_hsa04530	0.43994843
91	GABAergic synapse_Homo sapiens_hsa04727	0.41346869
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40536725
93	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.36000265
94	GnRH signaling pathway_Homo sapiens_hsa04912	0.35306447
95	Salivary secretion_Homo sapiens_hsa04970	0.33989769
96	Lysine degradation_Homo sapiens_hsa00310	0.33586930
97	Bile secretion_Homo sapiens_hsa04976	0.33059627
98	Pentose phosphate pathway_Homo sapiens_hsa00030	0.32663488
99	Hippo signaling pathway_Homo sapiens_hsa04390	0.31064942
100	Oocyte meiosis_Homo sapiens_hsa04114	0.27061579

AGKP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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