AGMO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent enzymes. Variations in this gene have been associated with decreased glucose-stimulated insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.77118885
2exogenous drug catabolic process (GO:0042738)7.68859875
3omega-hydroxylase P450 pathway (GO:0097267)7.11807941
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.01764735
5L-phenylalanine catabolic process (GO:0006559)7.01764735
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.62876290
7L-phenylalanine metabolic process (GO:0006558)6.62876290
8aromatic amino acid family catabolic process (GO:0009074)6.29379374
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.19668662
10drug metabolic process (GO:0017144)6.01314832
11oxidative demethylation (GO:0070989)5.70623566
12tryptophan catabolic process (GO:0006569)5.66635379
13indole-containing compound catabolic process (GO:0042436)5.66635379
14indolalkylamine catabolic process (GO:0046218)5.66635379
15alpha-linolenic acid metabolic process (GO:0036109)5.65757571
16bile acid biosynthetic process (GO:0006699)5.57311453
17kynurenine metabolic process (GO:0070189)5.38160505
18tryptophan metabolic process (GO:0006568)5.33350208
19high-density lipoprotein particle remodeling (GO:0034375)5.31084425
20urea metabolic process (GO:0019627)5.19175130
21urea cycle (GO:0000050)5.19175130
22glyoxylate metabolic process (GO:0046487)5.15219334
23complement activation, alternative pathway (GO:0006957)5.05825534
24phenylpropanoid metabolic process (GO:0009698)4.97234068
25sulfur amino acid catabolic process (GO:0000098)4.94461662
26protein carboxylation (GO:0018214)4.91401293
27peptidyl-glutamic acid carboxylation (GO:0017187)4.91401293
28regulation of fibrinolysis (GO:0051917)4.90216292
29regulation of cholesterol esterification (GO:0010872)4.88407931
30regulation of triglyceride catabolic process (GO:0010896)4.88230184
31regulation of protein activation cascade (GO:2000257)4.87552229
32negative regulation of fibrinolysis (GO:0051918)4.87213084
33bile acid metabolic process (GO:0008206)4.86236891
34alkaloid metabolic process (GO:0009820)4.86140241
35reverse cholesterol transport (GO:0043691)4.80418423
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.80248149
37cysteine metabolic process (GO:0006534)4.80141744
38nitrogen cycle metabolic process (GO:0071941)4.77120608
39homocysteine metabolic process (GO:0050667)4.70878541
40negative regulation of cytosolic calcium ion concentration (GO:0051481)4.66013492
41protein-lipid complex remodeling (GO:0034368)4.63500290
42macromolecular complex remodeling (GO:0034367)4.63500290
43plasma lipoprotein particle remodeling (GO:0034369)4.63500290
44phospholipid efflux (GO:0033700)4.60113604
45regulation of complement activation (GO:0030449)4.57993569
46aromatic amino acid family metabolic process (GO:0009072)4.53831012
47serine family amino acid catabolic process (GO:0009071)4.50295916
48triglyceride homeostasis (GO:0070328)4.45183405
49acylglycerol homeostasis (GO:0055090)4.45183405
50tyrosine metabolic process (GO:0006570)4.41997029
51cholesterol efflux (GO:0033344)4.29346805
52amino-acid betaine metabolic process (GO:0006577)4.29190307
53bile acid and bile salt transport (GO:0015721)4.28647366
54plasma lipoprotein particle clearance (GO:0034381)4.28469316
55alpha-amino acid catabolic process (GO:1901606)4.27399873
56negative regulation of cholesterol transport (GO:0032375)4.24481065
57negative regulation of sterol transport (GO:0032372)4.24481065
58coenzyme catabolic process (GO:0009109)4.20244634
59low-density lipoprotein particle remodeling (GO:0034374)4.11765618
60amine catabolic process (GO:0009310)4.09641497
61cellular biogenic amine catabolic process (GO:0042402)4.09641497
62cellular glucuronidation (GO:0052695)4.05881610
63ethanol metabolic process (GO:0006067)4.04221666
64indolalkylamine metabolic process (GO:0006586)4.02938161
65plasma lipoprotein particle assembly (GO:0034377)4.02183300
66cellular ketone body metabolic process (GO:0046950)4.01747687
67cellular amino acid catabolic process (GO:0009063)3.95436955
68lysine metabolic process (GO:0006553)3.92840155
69lysine catabolic process (GO:0006554)3.92840155
70ethanol oxidation (GO:0006069)3.92247414
71regulation of acrosome reaction (GO:0060046)3.91820053
72very-low-density lipoprotein particle assembly (GO:0034379)3.89222495
73fat-soluble vitamin biosynthetic process (GO:0042362)3.88464122
74imidazole-containing compound metabolic process (GO:0052803)3.86966185
75drug catabolic process (GO:0042737)3.83914266
76negative regulation of lipase activity (GO:0060192)3.83488523
77cellular modified amino acid catabolic process (GO:0042219)3.82275287
78benzene-containing compound metabolic process (GO:0042537)3.81155367
79glutamate metabolic process (GO:0006536)3.80381958
80positive regulation of triglyceride lipase activity (GO:0061365)3.79074937
81positive regulation of lipoprotein lipase activity (GO:0051006)3.79074937
82S-adenosylmethionine metabolic process (GO:0046500)3.74833932
83hormone catabolic process (GO:0042447)3.74702563
84cholesterol homeostasis (GO:0042632)3.74418519
85regulation of bile acid biosynthetic process (GO:0070857)3.71279734
86heme transport (GO:0015886)3.70645360
87arginine catabolic process (GO:0006527)3.69167727
88short-chain fatty acid metabolic process (GO:0046459)3.68911999
89fibrinolysis (GO:0042730)3.68243071
90positive regulation of lipid catabolic process (GO:0050996)3.67809584
91steroid catabolic process (GO:0006706)3.67062642
92arginine metabolic process (GO:0006525)3.66998685
93sterol homeostasis (GO:0055092)3.66662501
94very long-chain fatty acid metabolic process (GO:0000038)3.63707039
95plasma lipoprotein particle organization (GO:0071827)3.63308641
96cofactor catabolic process (GO:0051187)3.63033290
97negative regulation of cAMP-mediated signaling (GO:0043951)3.62924915
98uronic acid metabolic process (GO:0006063)3.62742708
99glucuronate metabolic process (GO:0019585)3.62742708
100aldehyde catabolic process (GO:0046185)3.62290937
101phospholipid homeostasis (GO:0055091)3.62134270
102glycine metabolic process (GO:0006544)3.61142986
103intestinal cholesterol absorption (GO:0030299)3.60997821
104organic acid catabolic process (GO:0016054)3.59514275
105carboxylic acid catabolic process (GO:0046395)3.59514275
106serine family amino acid metabolic process (GO:0009069)3.58528470
107protein-lipid complex assembly (GO:0065005)3.58375864
108complement activation (GO:0006956)3.56839356
109flavonoid metabolic process (GO:0009812)3.56658020
110blood coagulation, intrinsic pathway (GO:0007597)3.55897273
111protein activation cascade (GO:0072376)3.55845513
112acetyl-CoA metabolic process (GO:0006084)3.55089157
113serine family amino acid biosynthetic process (GO:0009070)3.51043856
114dicarboxylic acid biosynthetic process (GO:0043650)3.50588979
115complement activation, classical pathway (GO:0006958)3.50543822
116linoleic acid metabolic process (GO:0043651)3.50130432
117opioid receptor signaling pathway (GO:0038003)3.47768378
118negative regulation of blood coagulation (GO:0030195)3.46499718
119negative regulation of hemostasis (GO:1900047)3.46499718
120ketone body metabolic process (GO:1902224)3.46233973
121negative regulation of protein activation cascade (GO:2000258)3.44170394
122xenobiotic metabolic process (GO:0006805)3.39731260
123vitamin biosynthetic process (GO:0009110)3.39039873
124behavioral response to ethanol (GO:0048149)3.33089472
125regulation of plasminogen activation (GO:0010755)3.27624814
126negative regulation of coagulation (GO:0050819)3.18654260
127drug transmembrane transport (GO:0006855)3.17381456
128piRNA metabolic process (GO:0034587)3.16623419
129xenobiotic catabolic process (GO:0042178)3.15328240
130regulation of humoral immune response (GO:0002920)3.15140811
131negative regulation of complement activation (GO:0045916)3.08407912

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.35450901
2* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.46531833
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.20385193
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.89367880
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.82064983
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.63101456
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.31190732
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.64830231
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.39661049
10VDR_22108803_ChIP-Seq_LS180_Human2.60353247
11EZH2_22144423_ChIP-Seq_EOC_Human2.44470876
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.28167077
13IGF1R_20145208_ChIP-Seq_DFB_Human2.20775741
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14607454
15ZNF274_21170338_ChIP-Seq_K562_Hela2.12338567
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2984926
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75745658
18HTT_18923047_ChIP-ChIP_STHdh_Human1.74953317
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73190504
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.70639412
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69198648
22ER_23166858_ChIP-Seq_MCF-7_Human1.66844030
23CBP_20019798_ChIP-Seq_JUKART_Human1.64594706
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64594706
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62644525
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.60044211
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59557804
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59127601
29NANOG_19829295_ChIP-Seq_ESCs_Human1.53137268
30SOX2_19829295_ChIP-Seq_ESCs_Human1.53137268
31P300_19829295_ChIP-Seq_ESCs_Human1.52385340
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.52308077
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50763439
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50310366
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50310366
36STAT3_23295773_ChIP-Seq_U87_Human1.49067766
37TCF4_23295773_ChIP-Seq_U87_Human1.44405442
38* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44166064
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41182104
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37766234
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36306683
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35390020
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33462454
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33443411
45AR_25329375_ChIP-Seq_VCAP_Human1.31221299
46GATA1_22025678_ChIP-Seq_K562_Human1.30538919
47CLOCK_20551151_ChIP-Seq_293T_Human1.28762333
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28114312
49SMAD4_21799915_ChIP-Seq_A2780_Human1.27741164
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27438087
51TCF4_22108803_ChIP-Seq_LS180_Human1.25407835
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24207613
53HNF4A_19822575_ChIP-Seq_HepG2_Human1.23270435
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22503846
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21541678
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.20696261
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19575058
58FUS_26573619_Chip-Seq_HEK293_Human1.15953867
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15909376
60RXR_22108803_ChIP-Seq_LS180_Human1.13299099
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12699743
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11389860
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11345016
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.11058208
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.09446947
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09400504
67NCOR_22424771_ChIP-Seq_293T_Human1.08910875
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08558934
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07664437
70RUNX2_22187159_ChIP-Seq_PCA_Human1.06985973
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06960672
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.06960672
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05836863
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.04965282
75TP53_18474530_ChIP-ChIP_U2OS_Human1.04613613
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04287958
77* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03442316
78TP53_22573176_ChIP-Seq_HFKS_Human1.02692087
79P53_22387025_ChIP-Seq_ESCs_Mouse1.02482342
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01747900
81NANOG_20526341_ChIP-Seq_ESCs_Human1.01612864
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01580305
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00942255
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00252770
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99782854
86RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98754943
87SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98130239
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97797614
89SOX2_21211035_ChIP-Seq_LN229_Gbm0.97778809
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97468460
91IRF8_22096565_ChIP-ChIP_GC-B_Human0.96230543
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96067115
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96067115
94TAF15_26573619_Chip-Seq_HEK293_Human0.91372022
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90539485
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90412601
97GATA4_25053715_ChIP-Seq_YYC3_Human0.90258343
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87328568
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82879781
100CDX2_20551321_ChIP-Seq_CACO-2_Human0.82870890
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78654482
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78452003
103ESR2_21235772_ChIP-Seq_MCF-7_Human0.78174038
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.76779246
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75871833
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74682585
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.72654079
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72061225
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.71323703
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70488837
111EZH2_27294783_Chip-Seq_NPCs_Mouse0.69497581
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.68718182
113STAT1_17558387_ChIP-Seq_HELA_Human0.68259330
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.67797623
115CDX2_19796622_ChIP-Seq_MESCs_Mouse0.67438460
116RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67252265
117SUZ12_27294783_Chip-Seq_NPCs_Mouse0.66510920
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.66104154
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.65990992
120BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65722395
121BCAT_22108803_ChIP-Seq_LS180_Human0.65120128
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.64782338
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64430297
124NFE2_27457419_Chip-Seq_LIVER_Mouse0.64088159
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.63672104
126AR_20517297_ChIP-Seq_VCAP_Human0.62868734
127OCT4_21477851_ChIP-Seq_ESCs_Mouse0.62049827
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.61776207
129SOX2_20726797_ChIP-Seq_SW620_Human0.61507676
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.61375124
131CRX_20693478_ChIP-Seq_RETINA_Mouse0.61321266
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.61306943
133PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.61048958
134FOXA1_25552417_ChIP-Seq_VCAP_Human0.60724693
135GBX2_23144817_ChIP-Seq_PC3_Human0.59715569
136RUNX1_27457419_Chip-Seq_LIVER_Mouse0.59547018
137RARG_19884340_ChIP-ChIP_MEFs_Mouse0.59265767
138CEBPB_22108803_ChIP-Seq_LS180_Human0.58447048
139NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58247176
140CBP_21632823_ChIP-Seq_H3396_Human0.57580725
141ESET_19884257_ChIP-Seq_ESCs_Mouse0.55296860
142CDX2_22108803_ChIP-Seq_LS180_Human0.54294340
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.53710761
144ZFP57_27257070_Chip-Seq_ESCs_Mouse0.53219920
145BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.52348648
146MYC_19915707_ChIP-ChIP_AK7_Human0.51826123
147GATA2_21666600_ChIP-Seq_HMVEC_Human0.51465921
148EGR1_19032775_ChIP-ChIP_M12_Human0.51413615
149PU1_27457419_Chip-Seq_LIVER_Mouse0.49883521
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.49670837
151IRF1_19129219_ChIP-ChIP_H3396_Human0.49591906
152PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.48803546
153GATA2_19941826_ChIP-Seq_K562_Human0.48800815
154SMAD1_18555785_Chip-Seq_ESCs_Mouse0.48703322
155RARA_24833708_ChIP-Seq_LIVER_Mouse0.48628579
156CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.48352196
157FOXH1_21741376_ChIP-Seq_EPCs_Human0.47544201
158PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.47507335
159SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.47391418
160EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.47148456
161GATA1_19941826_ChIP-Seq_K562_Human0.46590903
162KDM2B_26808549_Chip-Seq_REH_Human0.46068877
163TP63_23658742_ChIP-Seq_EP156T_Human0.45775715

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.92136634
2MP0005360_urolithiasis7.34219749
3MP0005085_abnormal_gallbladder_physiolo6.18849932
4MP0005365_abnormal_bile_salt5.87608476
5MP0008875_abnormal_xenobiotic_pharmacok4.96009432
6MP0003252_abnormal_bile_duct3.84985446
7MP0003806_abnormal_nucleotide_metabolis3.76899967
8MP0010329_abnormal_lipoprotein_level3.57958809
9MP0009840_abnormal_foam_cell3.33194435
10MP0005083_abnormal_biliary_tract2.85484324
11MP0005332_abnormal_amino_acid2.72968206
12MP0001666_abnormal_nutrient_absorption2.71920184
13MP0003195_calcinosis2.65200496
14MP0003191_abnormal_cellular_cholesterol2.44546971
15MP0004019_abnormal_vitamin_homeostasis2.27745083
16MP0002118_abnormal_lipid_homeostasis2.17864523
17MP0000609_abnormal_liver_physiology2.04134142
18MP0002138_abnormal_hepatobiliary_system1.90615089
19MP0009697_abnormal_copulation1.73344353
20MP0001764_abnormal_homeostasis1.68960023
21MP0003868_abnormal_feces_composition1.67775727
22MP0005319_abnormal_enzyme/_coenzyme1.66411266
23MP0005551_abnormal_eye_electrophysiolog1.65527196
24MP0005451_abnormal_body_composition1.63771911
25MP0003011_delayed_dark_adaptation1.54132732
26MP0005584_abnormal_enzyme/coenzyme_acti1.53532085
27MP0001968_abnormal_touch/_nociception1.41902286
28MP0002254_reproductive_system_inflammat1.41179837
29MP0009780_abnormal_chondrocyte_physiolo1.40300129
30MP0003690_abnormal_glial_cell1.37984778
31MP0005670_abnormal_white_adipose1.37780993
32MP0003186_abnormal_redox_activity1.32211135
33MP0005646_abnormal_pituitary_gland1.25634187
34MP0001501_abnormal_sleep_pattern1.23259795
35MP0005647_abnormal_sex_gland1.22532439
36MP0009643_abnormal_urine_homeostasis1.21666168
37MP0009764_decreased_sensitivity_to1.17595172
38MP0003183_abnormal_peptide_metabolism1.14634623
39MP0003656_abnormal_erythrocyte_physiolo1.13957575
40MP0003879_abnormal_hair_cell1.09964389
41MP0001986_abnormal_taste_sensitivity1.08585036
42MP0003136_yellow_coat_color1.07627605
43MP0002876_abnormal_thyroid_physiology1.06699766
44MP0000604_amyloidosis1.05430416
45MP0009763_increased_sensitivity_to1.03712059
46MP0004043_abnormal_pH_regulation1.02063673
47MP0000598_abnormal_liver_morphology0.99090604
48MP0009053_abnormal_anal_canal0.98270243
49MP0005084_abnormal_gallbladder_morpholo0.94788795
50MP0005645_abnormal_hypothalamus_physiol0.93303092
51MP0008469_abnormal_protein_level0.91117276
52MP0003724_increased_susceptibility_to0.90908014
53MP0002272_abnormal_nervous_system0.89185651
54MP0002971_abnormal_brown_adipose0.88418241
55MP0003880_abnormal_central_pattern0.86518198
56MP0009745_abnormal_behavioral_response0.84956603
57MP0009642_abnormal_blood_homeostasis0.84208754
58MP0005334_abnormal_fat_pad0.83954143
59MP0004142_abnormal_muscle_tone0.83783152
60MP0009765_abnormal_xenobiotic_induced0.82424047
61MP0010386_abnormal_urinary_bladder0.82209438
62MP0005636_abnormal_mineral_homeostasis0.81729975
63MP0010368_abnormal_lymphatic_system0.80931183
64MP0004130_abnormal_muscle_cell0.80478181
65MP0004381_abnormal_hair_follicle0.80096668
66MP0001664_abnormal_digestion0.78337833
67MP0005376_homeostasis/metabolism_phenot0.77578561
68MP0005408_hypopigmentation0.77165665
69MP0005187_abnormal_penis_morphology0.76479477
70MP0005535_abnormal_body_temperature0.75941313
71MP0002078_abnormal_glucose_homeostasis0.72166318
72MP0001485_abnormal_pinna_reflex0.70352441
73MP0001661_extended_life_span0.68687062
74MP0004147_increased_porphyrin_level0.68363443
75MP0002638_abnormal_pupillary_reflex0.67575567
76MP0008775_abnormal_heart_ventricle0.66177962
77MP0006082_CNS_inflammation0.66031740
78MP0005448_abnormal_energy_balance0.65288830
79MP0002168_other_aberrant_phenotype0.64482190
80MP0004782_abnormal_surfactant_physiolog0.64009023
81MP0003646_muscle_fatigue0.63966115
82MP0000427_abnormal_hair_cycle0.63633596
83MP0003959_abnormal_lean_body0.63346233
84MP0005666_abnormal_adipose_tissue0.63227625
85MP0002249_abnormal_larynx_morphology0.62204325
86MP0001984_abnormal_olfaction0.61227610
87MP0003705_abnormal_hypodermis_morpholog0.61010061
88MP0006036_abnormal_mitochondrial_physio0.60772516
89MP0005503_abnormal_tendon_morphology0.60770259
90MP0005464_abnormal_platelet_physiology0.60436620
91MP0003075_altered_response_to0.60423961
92MP0001324_abnormal_eye_pigmentation0.60165802
93MP0000678_abnormal_parathyroid_gland0.59669845
94MP0003329_amyloid_beta_deposits0.59489850
95MP0005195_abnormal_posterior_eye0.59382252
96MP0001486_abnormal_startle_reflex0.58922326
97MP0002733_abnormal_thermal_nociception0.58656525
98MP0006292_abnormal_olfactory_placode0.57692440
99MP0002132_abnormal_respiratory_system0.57321179
100MP0000566_synostosis0.53135473
101MP0005266_abnormal_metabolism0.51789413
102MP0000639_abnormal_adrenal_gland0.51597070
103MP0005220_abnormal_exocrine_pancreas0.51427135
104MP0008877_abnormal_DNA_methylation0.51048429
105MP0000538_abnormal_urinary_bladder0.50909107
106MP0001756_abnormal_urination0.50887646
107MP0008789_abnormal_olfactory_epithelium0.50799388
108MP0009115_abnormal_fat_cell0.50570906
109MP0003941_abnormal_skin_development0.50429528
110MP0006035_abnormal_mitochondrial_morpho0.49583571
111MP0005058_abnormal_lysosome_morphology0.49425052
112MP0002136_abnormal_kidney_physiology0.48020683
113MP0006072_abnormal_retinal_apoptosis0.47292492
114MP0003638_abnormal_response/metabolism_0.47216880
115MP0009046_muscle_twitch0.46582666
116MP0003718_maternal_effect0.46573951
117MP0003567_abnormal_fetal_cardiomyocyte0.46343818
118MP0002557_abnormal_social/conspecific_i0.46086843
119MP0005395_other_phenotype0.45803191
120MP0009384_cardiac_valve_regurgitation0.44667378
121MP0002837_dystrophic_cardiac_calcinosis0.44632654
122MP0001853_heart_inflammation0.44548362
123MP0008872_abnormal_physiological_respon0.43909359
124MP0005166_decreased_susceptibility_to0.43695066
125MP0008874_decreased_physiological_sensi0.43507251
126MP0004883_abnormal_blood_vessel0.43231968
127MP0005164_abnormal_response_to0.43064343
128MP0002928_abnormal_bile_duct0.42336964
129MP0003953_abnormal_hormone_level0.40924358
130MP0000230_abnormal_systemic_arterial0.40786336
131MP0000249_abnormal_blood_vessel0.40187033
132MP0000579_abnormal_nail_morphology0.38616025
133MP0005167_abnormal_blood-brain_barrier0.37232798
134MP0003436_decreased_susceptibility_to0.36775146
135MP0002090_abnormal_vision0.36529240
136MP0008873_increased_physiological_sensi0.36487057
137MP0001881_abnormal_mammary_gland0.36132763
138MP0005595_abnormal_vascular_smooth0.35460836
139MP0002796_impaired_skin_barrier0.35172998
140MP0000920_abnormal_myelination0.32241248
141MP0002822_catalepsy0.31529442
142MP0002419_abnormal_innate_immunity0.30061664
143MP0001845_abnormal_inflammatory_respons0.29826025
144MP0002295_abnormal_pulmonary_circulatio0.29642426
145MP0003633_abnormal_nervous_system0.29285873
146MP0002060_abnormal_skin_morphology0.29052481

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.10380329
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.88551805
3Deep venous thrombosis (HP:0002625)6.74964355
4Prolonged partial thromboplastin time (HP:0003645)6.34369510
5Xanthomatosis (HP:0000991)6.13635165
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.12457670
7Hypobetalipoproteinemia (HP:0003563)6.08714470
8Complement deficiency (HP:0004431)5.50912090
9Hyperlipoproteinemia (HP:0010980)5.44455480
10Thyroid-stimulating hormone excess (HP:0002925)4.83376629
11Joint hemorrhage (HP:0005261)4.79938439
12Hypolipoproteinemia (HP:0010981)4.68449900
13Epidermoid cyst (HP:0200040)4.43639796
14Hyperammonemia (HP:0001987)4.41366709
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.36193339
16Hyperglycinemia (HP:0002154)4.32538391
17Hyperglycinuria (HP:0003108)4.20209686
18Abnormality of methionine metabolism (HP:0010901)4.18336792
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.17513475
20Abnormality of serine family amino acid metabolism (HP:0010894)4.15020036
21Abnormality of glycine metabolism (HP:0010895)4.15020036
22Hypoalphalipoproteinemia (HP:0003233)4.14595677
23Fat malabsorption (HP:0002630)4.14482975
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.09191074
25Abnormality of the common coagulation pathway (HP:0010990)4.04627696
26Abnormality of sulfur amino acid metabolism (HP:0004339)4.03100640
27Ketosis (HP:0001946)4.00869688
28Abnormality of complement system (HP:0005339)3.99017367
29Conjugated hyperbilirubinemia (HP:0002908)3.91742998
30Hypoglycemic coma (HP:0001325)3.75407516
31Hypercholesterolemia (HP:0003124)3.63712606
32Abnormality of pyrimidine metabolism (HP:0004353)3.57758033
33Abnormality of the intrinsic pathway (HP:0010989)3.45178958
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35335131
35Abnormality of fatty-acid metabolism (HP:0004359)3.34091194
36Systemic lupus erythematosus (HP:0002725)3.33534140
37Hyperbilirubinemia (HP:0002904)3.12190749
38Steatorrhea (HP:0002570)3.11407281
39Large for gestational age (HP:0001520)3.08832625
40Osteomalacia (HP:0002749)3.04642143
41Glomerulonephritis (HP:0000099)3.03732138
42Abnormality of serum amino acid levels (HP:0003112)2.99220596
43Myocardial infarction (HP:0001658)2.97742556
44Delayed CNS myelination (HP:0002188)2.93808675
45Fair hair (HP:0002286)2.92614333
46Ketoacidosis (HP:0001993)2.87147161
47Abnormality of nucleobase metabolism (HP:0010932)2.86755688
48Metabolic acidosis (HP:0001942)2.73652400
49Acanthocytosis (HP:0001927)2.72266566
50Dicarboxylic aciduria (HP:0003215)2.71603885
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.71603885
52Vascular calcification (HP:0004934)2.71258758
53Skin nodule (HP:0200036)2.71150642
54Amyloidosis (HP:0011034)2.68378487
55Intestinal atresia (HP:0011100)2.66161579
56Hepatocellular carcinoma (HP:0001402)2.65018056
57Hypochromic microcytic anemia (HP:0004840)2.61525297
58Spontaneous abortion (HP:0005268)2.58523148
59Hyperventilation (HP:0002883)2.58501634
60Lethargy (HP:0001254)2.54300577
61Pancreatic islet-cell hyperplasia (HP:0004510)2.53007509
62Abnormality of purine metabolism (HP:0004352)2.51254515
63Hypoglycemic seizures (HP:0002173)2.46934592
64Type II lissencephaly (HP:0007260)2.46641523
65Hyperphosphaturia (HP:0003109)2.40682505
66Cardiovascular calcification (HP:0011915)2.39305133
67Recurrent gram-negative bacterial infections (HP:0005420)2.29072415
68Volvulus (HP:0002580)2.28578452
69Cerebral edema (HP:0002181)2.27278755
70Abnormal gallbladder morphology (HP:0012437)2.24604550
71Hypophosphatemic rickets (HP:0004912)2.24371482
72Irritability (HP:0000737)2.24215266
73Pancreatitis (HP:0001733)2.24007130
74Proximal tubulopathy (HP:0000114)2.23866636
75Gaze-evoked nystagmus (HP:0000640)2.22872547
76Chronic hepatic failure (HP:0100626)2.20732999
77Abnormality of the renal cortex (HP:0011035)2.19783296
78Abnormality of proline metabolism (HP:0010907)2.19411832
79Hydroxyprolinuria (HP:0003080)2.19411832
80Renal cortical cysts (HP:0000803)2.19154073
81Esophageal varix (HP:0002040)2.18746009
82Tubular atrophy (HP:0000092)2.16709099
83Gingival bleeding (HP:0000225)2.16469215
84Generalized hypopigmentation of hair (HP:0011358)2.15512412
85Generalized aminoaciduria (HP:0002909)2.15190432
86Malnutrition (HP:0004395)2.14264860
87Pancreatic cysts (HP:0001737)2.12884388
88Mitral stenosis (HP:0001718)2.12438404
89Enlarged kidneys (HP:0000105)2.11625702
90Potter facies (HP:0002009)2.09505971
91Facial shape deformation (HP:0011334)2.09505971
92Menorrhagia (HP:0000132)2.08720883
93Cholelithiasis (HP:0001081)2.08467687
94Opisthotonus (HP:0002179)2.08352775
95Brushfield spots (HP:0001088)2.07884758
96Abnormal urine phosphate concentration (HP:0012599)2.06695345
97Nephritis (HP:0000123)2.05620621
98Rickets (HP:0002748)2.05329897
99Hypothermia (HP:0002045)2.05299562
100Sensorimotor neuropathy (HP:0007141)2.03171189
101Vomiting (HP:0002013)2.02151261
102Abnormality of vitamin metabolism (HP:0100508)1.97645211
103Hemorrhage of the eye (HP:0011885)1.97118000
104Cholecystitis (HP:0001082)1.96541930
105Abnormal gallbladder physiology (HP:0012438)1.96541930
106Hyperinsulinemic hypoglycemia (HP:0000825)1.95856558
107Agitation (HP:0000713)1.93971628
108Spastic diplegia (HP:0001264)1.89524732
109Hypertriglyceridemia (HP:0002155)1.88754501
110Poikilocytosis (HP:0004447)1.88097603
111Neonatal onset (HP:0003623)1.87491445
112Thrombophlebitis (HP:0004418)1.87464620
113Attenuation of retinal blood vessels (HP:0007843)1.87432713
114Pancreatic fibrosis (HP:0100732)1.87383233
115Elevated hepatic transaminases (HP:0002910)1.87249053
116Congenital stationary night blindness (HP:0007642)1.87155945
117Glycosuria (HP:0003076)1.86662021
118Abnormality of urine glucose concentration (HP:0011016)1.86662021
119Gout (HP:0001997)1.86317097
120Abnormal biliary tract physiology (HP:0012439)1.85038967
121Bile duct proliferation (HP:0001408)1.85038967
122Abnormal enzyme/coenzyme activity (HP:0012379)1.84528130
123Mesangial abnormality (HP:0001966)1.82230957
124Alkalosis (HP:0001948)1.81823650
125Pigmentary retinal degeneration (HP:0001146)1.81304076
126Abnormality of the gallbladder (HP:0005264)1.80984086
127Confusion (HP:0001289)1.80401112
128Molar tooth sign on MRI (HP:0002419)1.77912030
129Abnormality of midbrain morphology (HP:0002418)1.77912030
130Methylmalonic aciduria (HP:0012120)1.77132652
131Medial flaring of the eyebrow (HP:0010747)1.76249857
132Arthropathy (HP:0003040)1.75592493
133Abnormality of the vitreous humor (HP:0004327)1.75162801
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75018518
135Abnormality of alanine metabolism (HP:0010916)1.75018518
136Hyperalaninemia (HP:0003348)1.75018518
137Poor head control (HP:0002421)1.70621953
138Abnormality of the aortic arch (HP:0012303)1.69754267
139Abnormality of vitamin B metabolism (HP:0004340)1.68873326
140Congenital sensorineural hearing impairment (HP:0008527)1.67042005
141Abnormality of the vitamin B12 metabolism (HP:0004341)1.66671766
142Oligodontia (HP:0000677)1.65399283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.94657441
2SIK14.00209759
3FGFR43.77355751
4INSRR3.60390344
5ERN13.38763191
6ACVR1B3.20678094
7TAOK32.55326269
8MST1R2.36609634
9ERBB42.22382604
10IRAK32.19389010
11WNK32.09426411
12MAP4K22.02268240
13TGFBR22.00531211
14PNCK1.96385706
15MAPK151.93095832
16PRKCG1.92348966
17ADRBK11.88310301
18FRK1.84584176
19ZAK1.84426132
20PIK3CG1.79182078
21TIE11.78195501
22EPHB11.77394901
23CAMK1D1.70132779
24TYK21.64918614
25FGFR21.62302875
26MAP3K141.61780247
27TNIK1.58589709
28WNK41.50131019
29MAPK111.49176919
30GRK11.44621981
31PRKAA21.41848326
32KDR1.34088747
33MAP2K41.34040595
34TGFBR11.30006790
35MAP3K41.26238194
36EPHA31.18612117
37MAPK121.17975365
38LATS11.16527551
39CAMK1G1.15632044
40PKN11.14587260
41NTRK31.12951023
42JAK11.12538634
43NEK91.10922403
44PLK21.07266497
45PBK1.05261525
46ABL21.05051270
47MET1.03572846
48DAPK20.99408646
49JAK20.97380761
50MAPK70.97019214
51MAPK40.96208948
52PTK60.94658165
53PINK10.92350182
54PRKCI0.90653615
55GSK3A0.87491092
56ERBB20.87488045
57EIF2AK30.86936398
58BRSK20.86725697
59IRAK10.86615054
60SGK2230.86535052
61SGK4940.86535052
62MAP3K70.86225992
63MAP2K20.84291449
64GRK70.83925029
65TLK10.82935707
66PRKCZ0.81073207
67CAMKK20.79481191
68MAPK130.78828443
69GRK60.78640169
70CAMK2A0.77106584
71CSK0.76861349
72FLT30.76525545
73CSF1R0.75701737
74PRKACG0.75427781
75IKBKE0.75047007
76TBK10.74214752
77CAMK2G0.73827445
78PRKCQ0.73361814
79NTRK20.72048716
80NLK0.71435541
81IRAK20.69661607
82IRAK40.66326261
83EPHA40.65740999
84IGF1R0.65059529
85MKNK20.64293949
86SGK10.63401952
87FGFR30.63133384
88PAK30.61825998
89PIK3CA0.61796803
90TEC0.60647104
91ADRBK20.58469339
92PRKAA10.58284201
93NUAK10.58026734
94STK160.57851566
95SGK20.57827362
96LMTK20.56206927
97MAP2K60.56088578
98BLK0.54856456
99BMPR20.54047974
100MAP3K90.53504340
101CSNK1A10.53110278
102SGK30.52385985
103PDPK10.51728170
104CAMK10.51124851
105STK30.51095022
106MUSK0.50595003
107PDK20.50161327
108BMPR1B0.50090369
109STK38L0.49704657
110DYRK1A0.49644852
111STK390.48314377
112VRK10.47927878
113NEK20.47744258
114CSNK1E0.46233994
115TNK20.45553252
116MAP3K30.45516644
117PRKG20.45307585
118CDK60.45252937
119PRKCB0.45014016
120EIF2AK20.44895636
121CDK30.43042355
122DYRK30.42324503
123MARK10.41209699
124CSNK1G10.40638643
125CSNK1D0.40337221
126BCR0.40022307
127PRKCA0.39457714
128GRK50.39222200
129PRKD10.39210402
130AKT30.38911271
131MAP2K30.38274320
132ABL10.38255611
133DYRK20.38054705
134IKBKB0.37975690
135PHKG10.37957026
136PHKG20.37957026
137ERBB30.37871351
138PRKACB0.37206237
139MAP2K70.36945261
140CASK0.36553986
141EPHB20.35211288
142CSNK1G20.35120208
143CSNK1G30.34401237
144PRKACA0.33623042
145TYRO30.33443732
146MAPKAPK50.33337668
147RPS6KA30.33075549
148CHUK0.32619790
149OXSR10.32448564
150PRKCE0.32338912
151CAMK40.31920844
152CAMK2D0.31752122
153PRKG10.31536551

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.20110756
2Nitrogen metabolism_Homo sapiens_hsa009103.56795372
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10337389
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.89142919
5Arginine biosynthesis_Homo sapiens_hsa002202.74447047
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.65292611
7Complement and coagulation cascades_Homo sapiens_hsa046102.63942113
8Tryptophan metabolism_Homo sapiens_hsa003802.59870433
9Fatty acid degradation_Homo sapiens_hsa000712.52214680
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43505324
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.35953469
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35075439
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.28526415
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20289180
15Peroxisome_Homo sapiens_hsa041462.13429306
16Butanoate metabolism_Homo sapiens_hsa006502.12832729
17Histidine metabolism_Homo sapiens_hsa003402.11544095
18Propanoate metabolism_Homo sapiens_hsa006402.04123464
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.03479549
20PPAR signaling pathway_Homo sapiens_hsa033202.01293229
21Chemical carcinogenesis_Homo sapiens_hsa052042.00518140
22Fatty acid metabolism_Homo sapiens_hsa012121.99784781
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.98330051
24Staphylococcus aureus infection_Homo sapiens_hsa051501.88785025
25beta-Alanine metabolism_Homo sapiens_hsa004101.84512517
26Caffeine metabolism_Homo sapiens_hsa002321.82553467
27Fatty acid elongation_Homo sapiens_hsa000621.81543207
28Retinol metabolism_Homo sapiens_hsa008301.81445845
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.75443561
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72508265
31Steroid biosynthesis_Homo sapiens_hsa001001.67005388
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.58809312
33Sulfur metabolism_Homo sapiens_hsa009201.55141655
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50241991
35Phenylalanine metabolism_Homo sapiens_hsa003601.47208818
36Bile secretion_Homo sapiens_hsa049761.45000199
37Fat digestion and absorption_Homo sapiens_hsa049751.39238309
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39055930
39Tyrosine metabolism_Homo sapiens_hsa003501.36480485
40ABC transporters_Homo sapiens_hsa020101.35687535
41Starch and sucrose metabolism_Homo sapiens_hsa005001.33167269
42Selenocompound metabolism_Homo sapiens_hsa004501.30470104
43Pyruvate metabolism_Homo sapiens_hsa006201.25260736
44Folate biosynthesis_Homo sapiens_hsa007901.24956698
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22037037
46Vitamin digestion and absorption_Homo sapiens_hsa049771.20754540
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16971419
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.02708975
49Arginine and proline metabolism_Homo sapiens_hsa003301.02093899
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.00400630
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99533923
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98126191
53Fatty acid biosynthesis_Homo sapiens_hsa000610.96753621
54Vitamin B6 metabolism_Homo sapiens_hsa007500.96655011
55Carbon metabolism_Homo sapiens_hsa012000.92187416
56Biosynthesis of amino acids_Homo sapiens_hsa012300.89282317
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.84645481
58Sulfur relay system_Homo sapiens_hsa041220.83267992
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80831138
60Glycerolipid metabolism_Homo sapiens_hsa005610.77579229
61Glutathione metabolism_Homo sapiens_hsa004800.74363446
62Lysine degradation_Homo sapiens_hsa003100.70136729
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55120358
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54232257
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51357029
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49822901
67Metabolic pathways_Homo sapiens_hsa011000.49467251
68Phototransduction_Homo sapiens_hsa047440.48512435
69One carbon pool by folate_Homo sapiens_hsa006700.48486724
70Pentose phosphate pathway_Homo sapiens_hsa000300.47185408
71Linoleic acid metabolism_Homo sapiens_hsa005910.45289917
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43590769
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37451130
74Prion diseases_Homo sapiens_hsa050200.32301191
75Serotonergic synapse_Homo sapiens_hsa047260.31020415
76Dorso-ventral axis formation_Homo sapiens_hsa043200.28395457
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.28088260
78Galactose metabolism_Homo sapiens_hsa000520.26548560
79Olfactory transduction_Homo sapiens_hsa047400.26218286
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.21655041
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21080679
82Fructose and mannose metabolism_Homo sapiens_hsa000510.17876753
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17728363
84Taste transduction_Homo sapiens_hsa047420.15542604
85Ether lipid metabolism_Homo sapiens_hsa005650.15383709
86Insulin resistance_Homo sapiens_hsa049310.14480382
87Arachidonic acid metabolism_Homo sapiens_hsa005900.12607114
88Protein export_Homo sapiens_hsa030600.11488442
89Nicotine addiction_Homo sapiens_hsa050330.10902447
90Morphine addiction_Homo sapiens_hsa050320.08878240
91Oxidative phosphorylation_Homo sapiens_hsa001900.08733480
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.05497842
93Insulin secretion_Homo sapiens_hsa049110.05450014
94Basal transcription factors_Homo sapiens_hsa030220.05411761
95Fanconi anemia pathway_Homo sapiens_hsa034600.04722537
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04012899
97Ovarian steroidogenesis_Homo sapiens_hsa049130.02621422
98Mineral absorption_Homo sapiens_hsa049780.02526398
99Renin-angiotensin system_Homo sapiens_hsa046140.02451464
100African trypanosomiasis_Homo sapiens_hsa051430.02350944
101Sphingolipid metabolism_Homo sapiens_hsa00600-0.1585064
102Other glycan degradation_Homo sapiens_hsa00511-0.1452948
103Lysosome_Homo sapiens_hsa04142-0.1440153
104Malaria_Homo sapiens_hsa05144-0.1368221
105Pertussis_Homo sapiens_hsa05133-0.1361319
106Hepatitis C_Homo sapiens_hsa05160-0.1350428
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1336616
108Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1329068
109Regulation of autophagy_Homo sapiens_hsa04140-0.1319100
110Protein digestion and absorption_Homo sapiens_hsa04974-0.1197827
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0999953
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0558560
113Glucagon signaling pathway_Homo sapiens_hsa04922-0.0328712
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0292087
115AMPK signaling pathway_Homo sapiens_hsa04152-0.0224906
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0009872

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