AGO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.31459624
2nuclear pore organization (GO:0006999)4.90350262
3* pre-miRNA processing (GO:0031054)4.54765326
4mitotic sister chromatid cohesion (GO:0007064)4.31800978
5regulation of RNA export from nucleus (GO:0046831)4.02456140
6pore complex assembly (GO:0046931)3.98934936
7NLS-bearing protein import into nucleus (GO:0006607)3.94246952
8protein localization to kinetochore (GO:0034501)3.88543889
9regulation of histone H3-K27 methylation (GO:0061085)3.83093948
10negative regulation of histone methylation (GO:0031061)3.82296480
11cytoplasmic mRNA processing body assembly (GO:0033962)3.69207026
12histone H3-K4 trimethylation (GO:0080182)3.67480662
13mitotic nuclear envelope disassembly (GO:0007077)3.57792865
14N-terminal protein amino acid acetylation (GO:0006474)3.52653841
15positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.49671752
16membrane disassembly (GO:0030397)3.45913506
17nuclear envelope disassembly (GO:0051081)3.45913506
18protein localization to chromosome, centromeric region (GO:0071459)3.43962375
19heterochromatin organization (GO:0070828)3.42597596
20chromatin silencing (GO:0006342)3.41816552
21histone lysine methylation (GO:0034968)3.40823157
22histone H2A monoubiquitination (GO:0035518)3.31251948
23regulation of translational fidelity (GO:0006450)3.31055263
24cellular protein complex localization (GO:0034629)3.27980593
25glucocorticoid receptor signaling pathway (GO:0042921)3.25372372
26regulation of histone H3-K4 methylation (GO:0051569)3.21523850
27sister chromatid segregation (GO:0000819)3.20347471
28regulation of translational termination (GO:0006449)3.18277611
29interkinetic nuclear migration (GO:0022027)3.16355970
30protein complex localization (GO:0031503)3.16330534
31sister chromatid cohesion (GO:0007062)3.16217120
32TOR signaling (GO:0031929)3.15588576
33regulation of histone H3-K9 methylation (GO:0051570)3.13808842
34RNA stabilization (GO:0043489)3.12738406
35mRNA stabilization (GO:0048255)3.12738406
36regulation of nucleobase-containing compound transport (GO:0032239)3.12655854
37DNA unwinding involved in DNA replication (GO:0006268)3.10754826
38regulation of NFAT protein import into nucleus (GO:0051532)3.10229211
39regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.09956830
40histone lysine demethylation (GO:0070076)3.07517873
41protein K48-linked deubiquitination (GO:0071108)3.05790125
42chromosome condensation (GO:0030261)3.03483430
43regulation of spindle organization (GO:0090224)3.02714795
44peptidyl-lysine trimethylation (GO:0018023)3.00001908
45dosage compensation (GO:0007549)2.96903539
46positive regulation of gene expression, epigenetic (GO:0045815)2.94909795
47positive regulation of chromosome segregation (GO:0051984)2.94361989
48histone demethylation (GO:0016577)2.93761258
49chromatin assembly (GO:0031497)2.92888616
50histone methylation (GO:0016571)2.92848851
51positive regulation of mitotic sister chromatid separation (GO:1901970)2.91337843
52positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91337843
53positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91337843
54regulation of sister chromatid cohesion (GO:0007063)2.90891172
55regulation of mitotic spindle organization (GO:0060236)2.90723826
56mitotic sister chromatid segregation (GO:0000070)2.90273218
57DNA duplex unwinding (GO:0032508)2.89605345
58DNA conformation change (GO:0071103)2.89296209
59DNA geometric change (GO:0032392)2.87363437
60corticosteroid receptor signaling pathway (GO:0031958)2.87018566
61DNA packaging (GO:0006323)2.86331066
62* negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.85417252
63* negative regulation of translation, ncRNA-mediated (GO:0040033)2.85417252
64* regulation of translation, ncRNA-mediated (GO:0045974)2.85417252
65histone H3-K9 methylation (GO:0051567)2.84850858
66mitotic chromosome condensation (GO:0007076)2.84339416
67nuclear envelope organization (GO:0006998)2.84050391
68DNA replication initiation (GO:0006270)2.82034418
69definitive hemopoiesis (GO:0060216)2.78211803
70protein export from nucleus (GO:0006611)2.74794960
71peptidyl-lysine dimethylation (GO:0018027)2.74061442
72neural tube development (GO:0021915)2.73675271
73peptidyl-lysine methylation (GO:0018022)2.73638413
74hippo signaling (GO:0035329)2.73353960
75trophectodermal cell differentiation (GO:0001829)2.72900670
76positive regulation of histone deacetylation (GO:0031065)2.72792225
77regulation of hippo signaling (GO:0035330)2.72566045
78regulation of DNA damage checkpoint (GO:2000001)2.71872096
79positive regulation of cell cycle checkpoint (GO:1901978)2.71055651
80negative regulation of DNA repair (GO:0045738)2.70671755
81snRNA transcription (GO:0009301)2.70252533
82histone mRNA catabolic process (GO:0071044)2.69715108
83negative regulation of gene expression, epigenetic (GO:0045814)2.69479838
84negative regulation of chromatin modification (GO:1903309)2.65600164
85regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.64865164
86histone H3-K9 modification (GO:0061647)2.64845378
87intracellular estrogen receptor signaling pathway (GO:0030520)2.63849004
88DNA synthesis involved in DNA repair (GO:0000731)2.63002910
89morphogenesis of an epithelial sheet (GO:0002011)2.62515162
90negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.61605343
91mitotic metaphase plate congression (GO:0007080)2.60419536
92paraxial mesoderm development (GO:0048339)2.59373594
93nucleus organization (GO:0006997)2.58602598
94embryonic camera-type eye morphogenesis (GO:0048596)2.57466285
95protein localization to chromosome (GO:0034502)2.57410927
96regulation of gene silencing by RNA (GO:0060966)2.56903557
97regulation of posttranscriptional gene silencing (GO:0060147)2.56903557
98regulation of gene silencing by miRNA (GO:0060964)2.56903557
99protein demethylation (GO:0006482)2.55734240
100protein dealkylation (GO:0008214)2.55734240
101peptidyl-threonine dephosphorylation (GO:0035970)2.55692323
102regulation of mRNA stability (GO:0043488)2.55000421
103positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.54506081
104positive regulation of cell cycle G2/M phase transition (GO:1902751)2.54506081
105positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.54071832
106regulation of DNA endoreduplication (GO:0032875)2.54002358
107regulation of gene silencing (GO:0060968)2.53689485
108microtubule depolymerization (GO:0007019)2.53645606
109positive regulation of SMAD protein import into nucleus (GO:0060391)2.53035158
110histone H4-K16 acetylation (GO:0043984)2.52411771
111translesion synthesis (GO:0019985)2.52299217
112histone H3-K36 demethylation (GO:0070544)2.49376239
113spliceosomal tri-snRNP complex assembly (GO:0000244)2.48005415
114positive thymic T cell selection (GO:0045059)2.47755804
1153-UTR-mediated mRNA stabilization (GO:0070935)2.46808656
116* gene silencing by RNA (GO:0031047)2.46036432
117regulation of centriole replication (GO:0046599)2.45960631
118negative regulation of RNA splicing (GO:0033119)2.43676773
119regulation of chromatin binding (GO:0035561)2.42136436
120negative regulation of histone modification (GO:0031057)2.41919394
121histone H3-K9 demethylation (GO:0033169)2.41032654
122alternative mRNA splicing, via spliceosome (GO:0000380)2.40927578
123regulation of telomere maintenance via telomerase (GO:0032210)2.40834867
124DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.38810686
125monoubiquitinated protein deubiquitination (GO:0035520)2.38594831
126regulation of RNA stability (GO:0043487)2.38583307
127histone H3-K4 methylation (GO:0051568)2.37651381
128response to UV-C (GO:0010225)2.36946210
129* gene silencing (GO:0016458)2.36887113
130protein-DNA complex disassembly (GO:0032986)2.36096612
131nucleosome disassembly (GO:0006337)2.36096612
132thymic T cell selection (GO:0045061)2.35161102
133DNA replication-dependent nucleosome organization (GO:0034723)2.34751068
134DNA replication-dependent nucleosome assembly (GO:0006335)2.34751068
135mitotic G1 DNA damage checkpoint (GO:0031571)2.34300238
136negative regulation of mRNA metabolic process (GO:1903312)2.33820661
137histone H4-K5 acetylation (GO:0043981)2.31930946
138histone H4-K8 acetylation (GO:0043982)2.31930946
139mRNA transport (GO:0051028)2.31844183
140histone H2A ubiquitination (GO:0033522)2.30417575
141microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.30121727
142regulation of stem cell maintenance (GO:2000036)2.29910571
143determination of adult lifespan (GO:0008340)2.29790369
144regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.28827297
145chromatin assembly or disassembly (GO:0006333)2.28394483
146nodal signaling pathway (GO:0038092)2.27888599
147regulation of gamma-delta T cell differentiation (GO:0045586)2.27853310
148histone H4 acetylation (GO:0043967)2.27753758
149spindle assembly involved in mitosis (GO:0090307)2.27426996
150regulation of histone methylation (GO:0031060)2.27261605
151negative T cell selection (GO:0043383)2.26845027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.89712191
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.35245211
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.77901830
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.72683684
5MYC_22102868_ChIP-Seq_BL_Human3.63582016
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.15658213
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.40577791
8GATA1_22025678_ChIP-Seq_K562_Human2.37833284
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35408381
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19347435
11TCF7_22412390_ChIP-Seq_EML_Mouse2.18460033
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.06067415
13KDM2B_26808549_Chip-Seq_DND41_Human2.04862860
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.99170497
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98367695
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.97951239
17VDR_21846776_ChIP-Seq_THP-1_Human1.97115683
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94635955
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.93788888
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.93678414
21E2F1_21310950_ChIP-Seq_MCF-7_Human1.82515693
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80939933
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.80388930
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.80123809
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.80123809
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.80123809
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.76911064
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76749345
29CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.74859499
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72721494
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.68707534
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64364320
33CIITA_25753668_ChIP-Seq_RAJI_Human1.58601833
34AR_21909140_ChIP-Seq_LNCAP_Human1.58016849
35MAF_26560356_Chip-Seq_TH1_Human1.57882337
36UTX_26944678_Chip-Seq_JUKART_Human1.56422126
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54840691
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54831739
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.53867470
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52437525
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51829619
42CTNNB1_20460455_ChIP-Seq_HCT116_Human1.51517574
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47338630
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46003477
45AR_21572438_ChIP-Seq_LNCaP_Human1.45576868
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.43719075
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43610371
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.43413520
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41705117
50PKCTHETA_26484144_Chip-Seq_BREAST_Human1.39914698
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39760933
52AHR_22903824_ChIP-Seq_MCF-7_Human1.39063460
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38498305
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37794465
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36078102
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33520036
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33255716
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32494407
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30917314
60NCOR1_26117541_ChIP-Seq_K562_Human1.30849857
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30282931
62MYB_26560356_Chip-Seq_TH1_Human1.28794629
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28505222
64MYB_26560356_Chip-Seq_TH2_Human1.28130562
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28082870
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27899550
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27549603
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.27357605
69KDM5A_27292631_Chip-Seq_BREAST_Human1.26808426
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.26502658
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25199208
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.24552071
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23602500
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23224801
75EZH2_22144423_ChIP-Seq_EOC_Human1.22309100
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22160798
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20553058
78ZNF263_19887448_ChIP-Seq_K562_Human1.20292393
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20219470
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18955387
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18900069
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18900069
83MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18677447
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18520815
85FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17291333
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.17078843
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16468495
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15950094
89TFEB_21752829_ChIP-Seq_HELA_Human1.13425709
90SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12854457
91ATF3_27146783_Chip-Seq_COLON_Human1.12757841
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12389060
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11921796
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11323996
95NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.10408045
96CHD1_26751641_Chip-Seq_LNCaP_Human1.10375629
97KDM2B_26808549_Chip-Seq_K562_Human1.09792085
98NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07847072
99TP63_17297297_ChIP-ChIP_HaCaT_Human1.07782909
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07181904
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04710658
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04237172
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.03862925
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03801033
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03378059
106MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03068228
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02457538
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02107918
109VDR_24763502_ChIP-Seq_THP-1_Human1.02068660
110XRN2_22483619_ChIP-Seq_HELA_Human1.01315533
111MAF_26560356_Chip-Seq_TH2_Human1.01237958
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01173529
113WT1_19549856_ChIP-ChIP_CCG9911_Human1.00171162
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97952486
115RUNX1_22412390_ChIP-Seq_EML_Mouse0.97787263
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96453677
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96453677
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.96302928
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.95763817
120NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95560081
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95194327
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94737894
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93946417
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93658337
125GATA1_26923725_Chip-Seq_HPCs_Mouse0.93517106
126MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93395869
127GATA6_25053715_ChIP-Seq_YYC3_Human0.93344577
128YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93280237
129NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93151936
130PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92808458
131SCL_19346495_ChIP-Seq_HPC-7_Human0.92798866
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92704437
133PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91747132
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91638157
135STAT3_23295773_ChIP-Seq_U87_Human0.90417176
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.89590645
137TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89377635
138FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89202181
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84990082
140GF1B_26923725_Chip-Seq_HPCs_Mouse0.80869629
141RXR_22108803_ChIP-Seq_LS180_Human0.80535360
142NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78293522
143GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78106528
144TP53_16413492_ChIP-PET_HCT116_Human0.75755936
145PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.75372918
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75299923
147BRD4_25478319_ChIP-Seq_HGPS_Human0.74950100
148STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.74714238
149E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74020546

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.41904830
2MP0005076_abnormal_cell_differentiation3.28001687
3MP0003705_abnormal_hypodermis_morpholog2.78117544
4MP0002009_preneoplasia2.76497494
5MP0003111_abnormal_nucleus_morphology2.71871117
6MP0008057_abnormal_DNA_replication2.61147811
7MP0010094_abnormal_chromosome_stability2.50621802
8MP0010307_abnormal_tumor_latency2.35242633
9MP0003077_abnormal_cell_cycle2.27007163
10MP0004808_abnormal_hematopoietic_stem2.16909266
11MP0004957_abnormal_blastocyst_morpholog2.11585952
12MP0009697_abnormal_copulation1.98126512
13MP0003693_abnormal_embryo_hatching1.97218061
14MP0000569_abnormal_digit_pigmentation1.96766810
15MP0004197_abnormal_fetal_growth/weight/1.91281683
16MP0003123_paternal_imprinting1.91202001
17MP0000350_abnormal_cell_proliferation1.89481829
18MP0001672_abnormal_embryogenesis/_devel1.87609365
19MP0005380_embryogenesis_phenotype1.87609365
20MP0003984_embryonic_growth_retardation1.87572735
21MP0002088_abnormal_embryonic_growth/wei1.86951909
22MP0000733_abnormal_muscle_development1.86066774
23MP0001730_embryonic_growth_arrest1.85844645
24MP0003300_gastrointestinal_ulcer1.82092568
25MP0002086_abnormal_extraembryonic_tissu1.79929589
26MP0002396_abnormal_hematopoietic_system1.74960865
27MP0002084_abnormal_developmental_patter1.74623441
28MP0001697_abnormal_embryo_size1.67924474
29MP0003121_genomic_imprinting1.67401257
30MP0003566_abnormal_cell_adhesion1.60522525
31MP0003567_abnormal_fetal_cardiomyocyte1.59548985
32MP0003303_peritoneal_inflammation1.58148897
33MP0008961_abnormal_basal_metabolism1.56927016
34MP0005409_darkened_coat_color1.52588314
35MP0002085_abnormal_embryonic_tissue1.52407405
36MP0002877_abnormal_melanocyte_morpholog1.49785985
37MP0009278_abnormal_bone_marrow1.48055959
38MP0004233_abnormal_muscle_weight1.46734935
39MP0001873_stomach_inflammation1.46723066
40MP0000703_abnormal_thymus_morphology1.42800937
41MP0003122_maternal_imprinting1.41084104
42MP0003890_abnormal_embryonic-extraembry1.38042464
43MP0003656_abnormal_erythrocyte_physiolo1.37256668
44MP0002080_prenatal_lethality1.37216305
45MP0000428_abnormal_craniofacial_morphol1.28791764
46MP0009703_decreased_birth_body1.27163107
47MP0001849_ear_inflammation1.24899244
48MP0005623_abnormal_meninges_morphology1.24361911
49MP0008007_abnormal_cellular_replicative1.23576414
50MP0003763_abnormal_thymus_physiology1.23390435
51MP0003718_maternal_effect1.20103891
52MP0002925_abnormal_cardiovascular_devel1.18748825
53MP0003937_abnormal_limbs/digits/tail_de1.18008947
54MP0003943_abnormal_hepatobiliary_system1.16987930
55MP0001188_hyperpigmentation1.16047205
56MP0000490_abnormal_crypts_of1.15962437
57MP0005023_abnormal_wound_healing1.15012609
58MP0002398_abnormal_bone_marrow1.14886421
59MP0005397_hematopoietic_system_phenotyp1.14404487
60MP0001545_abnormal_hematopoietic_system1.14404487
61MP0001293_anophthalmia1.13443836
62MP0010030_abnormal_orbit_morphology1.12296155
63MP0003091_abnormal_cell_migration1.11732328
64MP0009053_abnormal_anal_canal1.10093771
65MP0002796_impaired_skin_barrier1.09075641
66MP0010630_abnormal_cardiac_muscle1.07708874
67MP0002166_altered_tumor_susceptibility1.07058633
68MP0004185_abnormal_adipocyte_glucose1.07037524
69MP0009672_abnormal_birth_weight1.06958859
70MP0010678_abnormal_skin_adnexa1.05999092
71MP0008770_decreased_survivor_rate1.05565139
72MP0010234_abnormal_vibrissa_follicle1.05557409
73MP0002653_abnormal_ependyma_morphology1.03989508
74MP0000383_abnormal_hair_follicle1.03480406
75MP0003941_abnormal_skin_development1.03224141
76MP0003453_abnormal_keratinocyte_physiol1.02959664
77MP0008877_abnormal_DNA_methylation1.01693247
78MP0003115_abnormal_respiratory_system1.00511456
79MP0003935_abnormal_craniofacial_develop1.00088361
80MP0004510_myositis0.97503444
81MP0002722_abnormal_immune_system0.97238070
82MP0004264_abnormal_extraembryonic_tissu0.97181974
83MP0000313_abnormal_cell_death0.96793293
84MP0005451_abnormal_body_composition0.96685161
85MP0000371_diluted_coat_color0.94862789
86MP0001286_abnormal_eye_development0.94401695
87MP0000266_abnormal_heart_morphology0.93310368
88MP0008058_abnormal_DNA_repair0.92011494
89MP0000432_abnormal_head_morphology0.90267002
90MP0009333_abnormal_splenocyte_physiolog0.89905335
91MP0008932_abnormal_embryonic_tissue0.89739735
92MP0005174_abnormal_tail_pigmentation0.87720863
93MP0002019_abnormal_tumor_incidence0.87328957
94MP0001915_intracranial_hemorrhage0.87232255
95MP0003119_abnormal_digestive_system0.86472341
96MP0002249_abnormal_larynx_morphology0.84380922
97MP0003786_premature_aging0.84132198
98MP0002405_respiratory_system_inflammati0.83861897
99MP0003448_altered_tumor_morphology0.83794243
100MP0002092_abnormal_eye_morphology0.82455855
101MP0005621_abnormal_cell_physiology0.82062958
102MP0002006_tumorigenesis0.81707770
103MP0001661_extended_life_span0.81521908
104MP0001784_abnormal_fluid_regulation0.81293620
105MP0005248_abnormal_Harderian_gland0.80847685
106MP0003828_pulmonary_edema0.80591199
107MP0005647_abnormal_sex_gland0.80489402
108MP0000537_abnormal_urethra_morphology0.80445507
109MP0001929_abnormal_gametogenesis0.79697587
110MP0004084_abnormal_cardiac_muscle0.78798957
111MP0000689_abnormal_spleen_morphology0.78512762
112MP0003699_abnormal_female_reproductive0.78206051
113MP0008995_early_reproductive_senescence0.78066372
114MP0002075_abnormal_coat/hair_pigmentati0.77813537
115MP0001348_abnormal_lacrimal_gland0.77789036
116MP0004381_abnormal_hair_follicle0.75350743
117MP0004947_skin_inflammation0.75122019
118MP0005384_cellular_phenotype0.72943087
119MP0003942_abnormal_urinary_system0.72727898
120MP0001879_abnormal_lymphatic_vessel0.72081373
121MP0002697_abnormal_eye_size0.72027848
122MP0005257_abnormal_intraocular_pressure0.72017948
123MP0006138_congestive_heart_failure0.71968838
124MP0002081_perinatal_lethality0.71799794
125MP0003045_fibrosis0.71655171
126MP0003385_abnormal_body_wall0.71592809
127MP0003646_muscle_fatigue0.71319102
128MP0002111_abnormal_tail_morphology0.71215981
129MP0002254_reproductive_system_inflammat0.70593768
130MP0004087_abnormal_muscle_fiber0.69450331
131MP0003755_abnormal_palate_morphology0.69084556
132MP0005310_abnormal_salivary_gland0.68961360
133MP0003861_abnormal_nervous_system0.67929777
134MP0005666_abnormal_adipose_tissue0.66897376

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99188362
2Chromsome breakage (HP:0040012)3.72605621
3Hyperacusis (HP:0010780)3.62557478
4Lip pit (HP:0100267)3.19782216
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.08806742
6Short 4th metacarpal (HP:0010044)3.08806742
7Abnormality of the fingertips (HP:0001211)3.07878636
8Renal duplication (HP:0000075)3.06328897
9Abnormality of the columella (HP:0009929)3.03536825
10Increased nuchal translucency (HP:0010880)2.93723591
11Depressed nasal tip (HP:0000437)2.92502263
12Elfin facies (HP:0004428)2.71872140
13Renovascular hypertension (HP:0100817)2.60810493
14Increased density of long bones (HP:0006392)2.59412552
15Acute myeloid leukemia (HP:0004808)2.59090743
16Long eyelashes (HP:0000527)2.55170256
17Macroorchidism (HP:0000053)2.54430501
18Heterotopia (HP:0002282)2.52382463
19Volvulus (HP:0002580)2.49820272
20Overriding aorta (HP:0002623)2.44569143
21Insomnia (HP:0100785)2.43328754
22Cerebral aneurysm (HP:0004944)2.42563908
23Prominent nose (HP:0000448)2.40179579
24Nephroblastoma (Wilms tumor) (HP:0002667)2.36041749
25Ependymoma (HP:0002888)2.34922432
26Neonatal hypoglycemia (HP:0001998)2.25991741
27Protruding tongue (HP:0010808)2.24135156
28Deviation of the thumb (HP:0009603)2.24116770
29Abnormality of the nasal septum (HP:0000419)2.22590276
30Bowel diverticulosis (HP:0005222)2.21737779
31Acute lymphatic leukemia (HP:0006721)2.20710059
32Broad face (HP:0000283)2.20648949
33Abnormality of chromosome stability (HP:0003220)2.19637316
34Shallow orbits (HP:0000586)2.19624493
35Embryonal renal neoplasm (HP:0011794)2.19465927
36Proximal placement of thumb (HP:0009623)2.19076979
37Abnormality of the 4th metacarpal (HP:0010012)2.17516617
38High anterior hairline (HP:0009890)2.16858559
39Sandal gap (HP:0001852)2.14632147
40Flat cornea (HP:0007720)2.14181586
41Astrocytoma (HP:0009592)2.12767252
42Abnormality of the astrocytes (HP:0100707)2.12767252
43Trigonocephaly (HP:0000243)2.09374532
44Obsessive-compulsive behavior (HP:0000722)2.08600650
45Narrow palate (HP:0000189)2.07808025
46Cystic hygroma (HP:0000476)2.06641321
47Absent radius (HP:0003974)2.06308998
48Underdeveloped nasal alae (HP:0000430)2.06120179
49Progressive cerebellar ataxia (HP:0002073)2.06002206
50Pointed chin (HP:0000307)2.05978769
51Spinal cord lesions (HP:0100561)2.05204686
52Syringomyelia (HP:0003396)2.05204686
53Gaze-evoked nystagmus (HP:0000640)2.04928708
54Urethral obstruction (HP:0000796)2.03820984
55Birth length less than 3rd percentile (HP:0003561)2.03722139
56Broad thumb (HP:0011304)2.03485742
57Genu recurvatum (HP:0002816)2.01992256
58Aplasia/Hypoplasia of the uvula (HP:0010293)1.99825966
59Supernumerary ribs (HP:0005815)1.99596202
60Basal cell carcinoma (HP:0002671)1.99519689
61Deep philtrum (HP:0002002)1.99277944
62Skin tags (HP:0010609)1.98927837
63Abnormality of chromosome segregation (HP:0002916)1.98923286
64Abnormality of the preputium (HP:0100587)1.97277560
65Subacute progressive viral hepatitis (HP:0006572)1.96781462
66Duplicated collecting system (HP:0000081)1.95808179
67Broad palm (HP:0001169)1.95317972
68Abnormality of the ischium (HP:0003174)1.93974992
69Asymmetry of the thorax (HP:0001555)1.90053681
70Abnormality of homocysteine metabolism (HP:0010919)1.89118309
71Homocystinuria (HP:0002156)1.89118309
72Bicuspid aortic valve (HP:0001647)1.88459382
73Meckel diverticulum (HP:0002245)1.87723154
74Absent forearm bone (HP:0003953)1.87563920
75Aplasia involving forearm bones (HP:0009822)1.87563920
76Rectal prolapse (HP:0002035)1.86988083
77Hypoplastic ischia (HP:0003175)1.85301345
78Intestinal fistula (HP:0100819)1.83799730
79Abnormality of the distal phalanx of the thumb (HP:0009617)1.82279218
80Selective tooth agenesis (HP:0001592)1.82260766
81Abnormality of the ileum (HP:0001549)1.82201162
82Curly hair (HP:0002212)1.81054085
83Obstructive sleep apnea (HP:0002870)1.80951874
84Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79908867
85Sacral dimple (HP:0000960)1.79137750
86Cutis marmorata (HP:0000965)1.79060193
87Malignant gastrointestinal tract tumors (HP:0006749)1.78703378
88Gastrointestinal carcinoma (HP:0002672)1.78703378
89Overlapping toe (HP:0001845)1.78592113
90Impaired smooth pursuit (HP:0007772)1.78256275
91Mitral valve prolapse (HP:0001634)1.78236416
92Bladder diverticulum (HP:0000015)1.78093678
93Abnormal number of incisors (HP:0011064)1.77940256
94Glioma (HP:0009733)1.76615755
95Autoimmune thrombocytopenia (HP:0001973)1.76116651
96Hallux valgus (HP:0001822)1.76012686
97Facial hemangioma (HP:0000329)1.75909638
98Rhabdomyosarcoma (HP:0002859)1.75789503
99Abnormality of oral frenula (HP:0000190)1.75503990
100Deviation of the hallux (HP:0010051)1.75368825
101Abnormality of the diencephalon (HP:0010662)1.75254560
102Clubbing of toes (HP:0100760)1.74664266
103Clumsiness (HP:0002312)1.74059198
104Dilatation of the ascending aorta (HP:0005111)1.73864260
105Hyporeflexia of lower limbs (HP:0002600)1.73450892
106Dislocated radial head (HP:0003083)1.73409194
107Aortic aneurysm (HP:0004942)1.72504806
108Supernumerary bones of the axial skeleton (HP:0009144)1.72359998
109Ectopic kidney (HP:0000086)1.72043166
110Ankyloglossia (HP:0010296)1.71969313
111Skull defect (HP:0001362)1.71372028
112Chin dimple (HP:0010751)1.71294338
113Protrusio acetabuli (HP:0003179)1.70729534
114Neoplasm of striated muscle (HP:0009728)1.70483593
115Cubitus valgus (HP:0002967)1.70040431
116Subaortic stenosis (HP:0001682)1.69736221
117Abnormality of the left ventricular outflow tract (HP:0011103)1.69736221
118Myelodysplasia (HP:0002863)1.69389373
119Dysmetric saccades (HP:0000641)1.69312539
120Truncal obesity (HP:0001956)1.68081424
121Papillary thyroid carcinoma (HP:0002895)1.67603830
122Deep palmar crease (HP:0006191)1.67381631
123Broad phalanges of the hand (HP:0009768)1.67045330
124Urinary bladder sphincter dysfunction (HP:0002839)1.66956641
125Aqueductal stenosis (HP:0002410)1.66601603
126Abnormality of the pubic bones (HP:0003172)1.66153777
127Enlarged penis (HP:0000040)1.66020846
128Anal stenosis (HP:0002025)1.65563564
129Midline defect of the nose (HP:0004122)1.65504940
130Aplasia/Hypoplasia of the sternum (HP:0006714)1.65480753
131Pelvic girdle muscle weakness (HP:0003749)1.65443260
132Preauricular skin tag (HP:0000384)1.65010483
133Abnormality of the renal collecting system (HP:0004742)1.64834673
134Sparse lateral eyebrow (HP:0005338)1.64832441
135Neoplasm of the oral cavity (HP:0100649)1.64257665
136Medulloblastoma (HP:0002885)1.64148105
137Persistence of primary teeth (HP:0006335)1.63246898
138Neoplasm of the adrenal cortex (HP:0100641)1.63152611
139Abnormality of the radial head (HP:0003995)1.61901062
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.61532185
141Rib fusion (HP:0000902)1.60852994
142Megalocornea (HP:0000485)1.59944777
143High pitched voice (HP:0001620)1.59898669
144Neoplasm of the heart (HP:0100544)1.59147387
145Ankle contracture (HP:0006466)1.57749672
146Vertebral arch anomaly (HP:0008438)1.57725503
147Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.57533133
148Transitional cell carcinoma of the bladder (HP:0006740)1.57268798
149Absent frontal sinuses (HP:0002688)1.56530960
150Abnormality of the labia minora (HP:0012880)1.56180869
151Cafe-au-lait spot (HP:0000957)1.53606338
152Bladder carcinoma (HP:0002862)1.53053037
153Bladder neoplasm (HP:0009725)1.53053037
154Hypoplasia of the maxilla (HP:0000327)1.52240409
155Broad finger (HP:0001500)1.51244338
156Spina bifida occulta (HP:0003298)1.50992611
157Limited elbow extension (HP:0001377)1.50773797
158Genetic anticipation (HP:0003743)1.50644595
159Low anterior hairline (HP:0000294)1.50151398
160Abnormality of the carotid arteries (HP:0005344)1.49881602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.42250534
2EEF2K2.93819071
3TRIB32.87915700
4MAP3K102.77711864
5FRK2.38819698
6CDC72.38138049
7NEK22.25767697
8PKN22.22705914
9BRD42.15909318
10INSRR2.09678320
11SMG11.92015297
12ALK1.87622599
13AKT31.80904839
14STK101.80359700
15MAP4K11.79305491
16MTOR1.74294892
17LATS11.68978075
18CDK61.65791491
19CAMK1D1.51619738
20WNK11.51303818
21TTN1.46751247
22SCYL21.46660613
23STK31.45837215
24RIPK11.45473615
25ICK1.42058836
26CDK41.40477303
27TAOK11.36680837
28CAMK1G1.36468568
29PDGFRA1.35110239
30EIF2AK11.30369242
31DMPK1.28446939
32STK241.27536197
33FGFR31.26768547
34PDGFRB1.24023216
35SGK21.23838717
36WEE11.22698205
37BMX1.16298325
38TTK1.16130063
39NEK11.15813934
40CHEK11.15250097
41MAP3K91.14938992
42PRPF4B1.13848290
43SRPK11.11637223
44PIM11.10166537
45TSSK61.06702437
46MAP3K81.05360812
47ZAK1.04706025
48TAF11.03472440
49RPS6KA41.02947362
50FGFR11.02860893
51STK41.01543976
52NLK1.00770352
53IRAK30.99991093
54CHEK20.99959503
55CDK70.99301650
56MST1R0.97235675
57TNIK0.96709810
58PTK60.95471196
59MAP3K130.93643255
60RPS6KB20.93114111
61TYRO30.91572130
62GRK60.91482583
63ATR0.91392466
64SIK20.89362390
65LRRK20.87497331
66MAP2K30.87160291
67STK38L0.87075403
68LATS20.86561400
69CDK20.86376298
70PAK20.86102459
71PLK40.85320015
72ZAP700.84568654
73CDK90.83870326
74JAK30.83367620
75ATM0.80627638
76MARK30.79457280
77ITK0.78535999
78EIF2AK30.78442746
79CHUK0.77398554
80AURKB0.77201570
81BUB10.77187516
82TRPM70.76855791
83MELK0.76324030
84FGFR20.74810895
85SIK10.74808685
86PBK0.74104673
87HCK0.73910191
88SGK30.73435288
89MET0.72425358
90DDR20.71174835
91PLK10.70976191
92SGK4940.70565388
93SGK2230.70565388
94YES10.66358287
95PLK30.66038992
96PNCK0.64795816
97CDK80.62469862
98BRSK20.62309036
99IRAK20.61549439
100BMPR1B0.61509428
101MAP3K70.61197870
102CDK10.58168879
103ACVR1B0.57551249
104CSNK1D0.56205651
105TXK0.55607779
106MAPK100.54207519
107NUAK10.53679209
108PTK20.53470476
109PAK40.51860943
110MAPK110.51787426
111PRKD30.51771982
112MKNK10.51722014
113PRKAA20.50393116
114MAP3K30.50175333
115AKT20.49540358
116MKNK20.49527531
117CDC42BPA0.49404823
118PRKAA10.49221160
119RPS6KB10.49127820
120CAMK40.48718605
121EIF2AK20.48574214
122MAPK140.47656640
123CLK10.45231021
124MARK20.44929241
125SIK30.44838246
126PRKDC0.44729538
127RPS6KA10.44570158
128FGFR40.44369585
129MAPK10.43174292
130MAPK80.43067212
131CSNK1E0.42942054
132STK390.42467173
133JAK10.41605308
134MAP3K50.41433330
135DYRK1B0.40969178
136PRKD20.40220660
137GSK3B0.39365182
138AKT10.39353730
139IRAK10.38747207
140STK110.37248479
141PASK0.37122997
142PRKCH0.36089443
143RET0.35202980

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052201.88947090
2RNA transport_Homo sapiens_hsa030131.87928880
3Non-homologous end-joining_Homo sapiens_hsa034501.87364520
4Cell cycle_Homo sapiens_hsa041101.79483350
5mTOR signaling pathway_Homo sapiens_hsa041501.68125667
6mRNA surveillance pathway_Homo sapiens_hsa030151.64992572
7MicroRNAs in cancer_Homo sapiens_hsa052061.61664675
8Adherens junction_Homo sapiens_hsa045201.41127081
9T cell receptor signaling pathway_Homo sapiens_hsa046601.39837140
10Small cell lung cancer_Homo sapiens_hsa052221.37952276
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37380784
12Viral myocarditis_Homo sapiens_hsa054161.35469451
13Viral carcinogenesis_Homo sapiens_hsa052031.34883784
14p53 signaling pathway_Homo sapiens_hsa041151.31691325
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31333995
16HTLV-I infection_Homo sapiens_hsa051661.28765109
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27050139
18Spliceosome_Homo sapiens_hsa030401.25890960
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25648066
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.25385944
21Proteoglycans in cancer_Homo sapiens_hsa052051.24546710
22Acute myeloid leukemia_Homo sapiens_hsa052211.24421041
23Colorectal cancer_Homo sapiens_hsa052101.20720454
24Dorso-ventral axis formation_Homo sapiens_hsa043201.20590328
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18340651
26Non-small cell lung cancer_Homo sapiens_hsa052231.17881086
27Endometrial cancer_Homo sapiens_hsa052131.17450509
28Basal transcription factors_Homo sapiens_hsa030221.15480231
29B cell receptor signaling pathway_Homo sapiens_hsa046621.14597858
30Hippo signaling pathway_Homo sapiens_hsa043901.10633013
31Oocyte meiosis_Homo sapiens_hsa041141.10430171
32DNA replication_Homo sapiens_hsa030301.09559263
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09129277
34Glioma_Homo sapiens_hsa052141.06919854
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.06538204
36Renal cell carcinoma_Homo sapiens_hsa052111.05801275
37Hepatitis B_Homo sapiens_hsa051611.05059240
38Pancreatic cancer_Homo sapiens_hsa052121.04621963
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03631715
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02761866
41Circadian rhythm_Homo sapiens_hsa047101.01300614
42Prostate cancer_Homo sapiens_hsa052150.99922843
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99472192
44Basal cell carcinoma_Homo sapiens_hsa052170.99053299
45Lysine degradation_Homo sapiens_hsa003100.98943419
46Primary immunodeficiency_Homo sapiens_hsa053400.98867663
47Mismatch repair_Homo sapiens_hsa034300.96529479
48Antigen processing and presentation_Homo sapiens_hsa046120.96350318
49Notch signaling pathway_Homo sapiens_hsa043300.95547782
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95311537
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94362619
52Focal adhesion_Homo sapiens_hsa045100.93367085
53Melanoma_Homo sapiens_hsa052180.92879452
54Epstein-Barr virus infection_Homo sapiens_hsa051690.91491355
55Osteoclast differentiation_Homo sapiens_hsa043800.90800003
56Thyroid cancer_Homo sapiens_hsa052160.90352305
57Herpes simplex infection_Homo sapiens_hsa051680.89686015
58VEGF signaling pathway_Homo sapiens_hsa043700.89347600
59HIF-1 signaling pathway_Homo sapiens_hsa040660.89132406
60Systemic lupus erythematosus_Homo sapiens_hsa053220.89059843
61Selenocompound metabolism_Homo sapiens_hsa004500.88856463
62Measles_Homo sapiens_hsa051620.88510472
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88467968
64FoxO signaling pathway_Homo sapiens_hsa040680.87548193
65Prolactin signaling pathway_Homo sapiens_hsa049170.86871524
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85479808
67Toxoplasmosis_Homo sapiens_hsa051450.84998901
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84906890
69Pathways in cancer_Homo sapiens_hsa052000.84594390
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.83351495
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.83316144
72Base excision repair_Homo sapiens_hsa034100.83296071
73Estrogen signaling pathway_Homo sapiens_hsa049150.81538931
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80734080
75TGF-beta signaling pathway_Homo sapiens_hsa043500.80643391
76Wnt signaling pathway_Homo sapiens_hsa043100.79953618
77One carbon pool by folate_Homo sapiens_hsa006700.79768639
78Nucleotide excision repair_Homo sapiens_hsa034200.79656405
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79302550
80ErbB signaling pathway_Homo sapiens_hsa040120.78931077
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.78789631
82Insulin signaling pathway_Homo sapiens_hsa049100.78409387
83Fanconi anemia pathway_Homo sapiens_hsa034600.77337685
84Tight junction_Homo sapiens_hsa045300.77126001
85Apoptosis_Homo sapiens_hsa042100.76780013
86Type II diabetes mellitus_Homo sapiens_hsa049300.75114428
87Bladder cancer_Homo sapiens_hsa052190.73523733
88MAPK signaling pathway_Homo sapiens_hsa040100.73215521
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.73168842
90Platelet activation_Homo sapiens_hsa046110.72826195
91Insulin resistance_Homo sapiens_hsa049310.69908566
92Hedgehog signaling pathway_Homo sapiens_hsa043400.69303211
93RNA degradation_Homo sapiens_hsa030180.69145766
94Inositol phosphate metabolism_Homo sapiens_hsa005620.68646696
95AMPK signaling pathway_Homo sapiens_hsa041520.68044998
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67697773
97Homologous recombination_Homo sapiens_hsa034400.66306765
98Dilated cardiomyopathy_Homo sapiens_hsa054140.65936486
99Taste transduction_Homo sapiens_hsa047420.65346571
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64850854
101Alcoholism_Homo sapiens_hsa050340.64043334
102Hematopoietic cell lineage_Homo sapiens_hsa046400.63739507
103Fatty acid biosynthesis_Homo sapiens_hsa000610.62575846
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61862498
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61651385
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61566150
107Shigellosis_Homo sapiens_hsa051310.60610672
108Choline metabolism in cancer_Homo sapiens_hsa052310.60425156
109TNF signaling pathway_Homo sapiens_hsa046680.60231596
110Rap1 signaling pathway_Homo sapiens_hsa040150.59494048
111Endocytosis_Homo sapiens_hsa041440.59364560
112Leishmaniasis_Homo sapiens_hsa051400.59113648
113Influenza A_Homo sapiens_hsa051640.55571946
114Long-term potentiation_Homo sapiens_hsa047200.55239177
115Hepatitis C_Homo sapiens_hsa051600.54568482
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.51161399
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50933805
118RNA polymerase_Homo sapiens_hsa030200.48359578
119Cholinergic synapse_Homo sapiens_hsa047250.47753731
120Vitamin B6 metabolism_Homo sapiens_hsa007500.47622768

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