AGO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.80931782
2fucose catabolic process (GO:0019317)4.56117867
3L-fucose metabolic process (GO:0042354)4.56117867
4L-fucose catabolic process (GO:0042355)4.56117867
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.06596487
6L-amino acid import (GO:0043092)4.02771318
7locomotory exploration behavior (GO:0035641)3.91647591
8interkinetic nuclear migration (GO:0022027)3.90938303
9neural tube formation (GO:0001841)3.83019147
10indole-containing compound catabolic process (GO:0042436)3.67129179
11indolalkylamine catabolic process (GO:0046218)3.67129179
12tryptophan catabolic process (GO:0006569)3.67129179
13cilium or flagellum-dependent cell motility (GO:0001539)3.59740468
14regulation of hippo signaling (GO:0035330)3.47534090
15kynurenine metabolic process (GO:0070189)3.47049454
16amino acid import (GO:0043090)3.39601167
17response to pheromone (GO:0019236)3.37446798
18indolalkylamine metabolic process (GO:0006586)3.33660961
19axon ensheathment in central nervous system (GO:0032291)3.32627984
20central nervous system myelination (GO:0022010)3.32627984
21negative regulation of neurotransmitter secretion (GO:0046929)3.28543831
22detection of light stimulus involved in sensory perception (GO:0050962)3.28503306
23detection of light stimulus involved in visual perception (GO:0050908)3.28503306
24cAMP catabolic process (GO:0006198)3.28207170
25positive regulation of developmental pigmentation (GO:0048087)3.25597992
26detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21607771
27tryptophan metabolic process (GO:0006568)3.21235170
28protein K11-linked deubiquitination (GO:0035871)3.18009190
29regulation of pigment cell differentiation (GO:0050932)3.15879660
30histone H3-K4 trimethylation (GO:0080182)3.06086565
31establishment of protein localization to Golgi (GO:0072600)3.04702170
32neuronal action potential (GO:0019228)3.04277384
33epithelial cilium movement (GO:0003351)3.03470955
34neuron cell-cell adhesion (GO:0007158)2.99671743
35regulation of short-term neuronal synaptic plasticity (GO:0048172)2.99654769
36negative regulation of neurotransmitter transport (GO:0051589)2.96984669
37ionotropic glutamate receptor signaling pathway (GO:0035235)2.96349199
38axoneme assembly (GO:0035082)2.94560048
39snRNA transcription (GO:0009301)2.94020177
40cellular ketone body metabolic process (GO:0046950)2.92397077
41nephron epithelium morphogenesis (GO:0072088)2.91858688
42nephron tubule morphogenesis (GO:0072078)2.91858688
43cilium movement (GO:0003341)2.90376431
44cilium organization (GO:0044782)2.85404144
45positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.84320215
46negative regulation of cytosolic calcium ion concentration (GO:0051481)2.81375181
47cilium assembly (GO:0042384)2.78920148
48nonmotile primary cilium assembly (GO:0035058)2.78380612
49cilium morphogenesis (GO:0060271)2.74988738
50nucleus localization (GO:0051647)2.74451455
51positive regulation of CREB transcription factor activity (GO:0032793)2.74354926
52proline transport (GO:0015824)2.73968454
53transmission of nerve impulse (GO:0019226)2.73576048
54positive regulation of cellular amide metabolic process (GO:0034250)2.72594481
55indole-containing compound metabolic process (GO:0042430)2.72590631
56regulation of activation of Janus kinase activity (GO:0010533)2.72466110
57monoubiquitinated protein deubiquitination (GO:0035520)2.72252791
58cerebellar Purkinje cell differentiation (GO:0021702)2.71838852
59presynaptic membrane assembly (GO:0097105)2.71618340
60cornea development in camera-type eye (GO:0061303)2.68674817
61activated T cell proliferation (GO:0050798)2.68390049
62primary amino compound metabolic process (GO:1901160)2.68199570
63synaptic vesicle endocytosis (GO:0048488)2.67725081
64serotonin metabolic process (GO:0042428)2.67598088
65behavioral response to ethanol (GO:0048149)2.66204519
66nerve growth factor signaling pathway (GO:0038180)2.64646861
67regulation of gene silencing by RNA (GO:0060966)2.64133850
68regulation of posttranscriptional gene silencing (GO:0060147)2.64133850
69regulation of gene silencing by miRNA (GO:0060964)2.64133850
70cellular response to sterol (GO:0036315)2.63848788
71dendrite morphogenesis (GO:0048813)2.62711894
72neutrophil activation involved in immune response (GO:0002283)2.62616876
73postsynaptic membrane organization (GO:0001941)2.62465881
74kidney morphogenesis (GO:0060993)2.62204502
75photoreceptor cell maintenance (GO:0045494)2.62038812
76long-term synaptic potentiation (GO:0060291)2.61788209
77ketone body metabolic process (GO:1902224)2.61611261
78reflex (GO:0060004)2.61387186
79regulation of synaptic vesicle exocytosis (GO:2000300)2.61170126
80spinal cord motor neuron differentiation (GO:0021522)2.60882288
81glutamate receptor signaling pathway (GO:0007215)2.60333356
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.60124337
83protein K48-linked deubiquitination (GO:0071108)2.59848818
84central nervous system neuron axonogenesis (GO:0021955)2.58903304
85protein polyglutamylation (GO:0018095)2.58229422
86myelination (GO:0042552)2.57982000
87replication fork processing (GO:0031297)2.55931354
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55350874
89appendage development (GO:0048736)2.54914783
90limb development (GO:0060173)2.54914783
91adult walking behavior (GO:0007628)2.54806572
92cerebellar granule cell differentiation (GO:0021707)2.53622008
93axon ensheathment (GO:0008366)2.52652332
94ensheathment of neurons (GO:0007272)2.52652332
95* negative regulation of translation, ncRNA-mediated (GO:0040033)2.52400215
96* regulation of translation, ncRNA-mediated (GO:0045974)2.52400215
97* negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.52400215
98negative regulation of systemic arterial blood pressure (GO:0003085)2.52207054
99long-chain fatty acid biosynthetic process (GO:0042759)2.52038840
100synaptic transmission, glutamatergic (GO:0035249)2.51934891
101presynaptic membrane organization (GO:0097090)2.51868270
102renal tubule morphogenesis (GO:0061333)2.50006935
103peristalsis (GO:0030432)2.49754756
104oxidative demethylation (GO:0070989)2.49570072
105rRNA catabolic process (GO:0016075)2.48908881
106pyrimidine nucleobase catabolic process (GO:0006208)2.47773802
107embryonic epithelial tube formation (GO:0001838)2.47119064
108synaptic vesicle maturation (GO:0016188)2.46853489
109limb bud formation (GO:0060174)2.46619847
110hindbrain development (GO:0030902)2.46617516
111regulation of nuclear cell cycle DNA replication (GO:0033262)2.46607502
112response to lipoprotein particle (GO:0055094)2.46175328
113sulfation (GO:0051923)2.45966513
114negative regulation of DNA-dependent DNA replication (GO:2000104)2.44883478
115regulation of establishment of cell polarity (GO:2000114)2.44371071
116reciprocal DNA recombination (GO:0035825)2.44206530
117reciprocal meiotic recombination (GO:0007131)2.44206530
118neuronal action potential propagation (GO:0019227)2.43824658
119regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.42361715
120regulation of telomere maintenance (GO:0032204)2.42283036
121negative regulation of mast cell activation (GO:0033004)2.41835673
122inner ear receptor stereocilium organization (GO:0060122)2.41650008
123cardiovascular system development (GO:0072358)2.40728019
124Rap protein signal transduction (GO:0032486)2.39573249
125negative regulation of astrocyte differentiation (GO:0048712)2.39126960
126retinal cone cell development (GO:0046549)2.38948079
127regulation of synaptic vesicle transport (GO:1902803)2.38743314
128fucosylation (GO:0036065)2.38660323
129membrane depolarization during action potential (GO:0086010)2.38193832
130neuron-neuron synaptic transmission (GO:0007270)2.37803462
131vesicle transport along microtubule (GO:0047496)2.37605990
132positive regulation of type 2 immune response (GO:0002830)2.37494607
133antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37231672
134regulation of voltage-gated calcium channel activity (GO:1901385)2.36848419
135regulation of action potential (GO:0098900)2.36840290
136histone H3-K9 methylation (GO:0051567)2.36677462
137neuron maturation (GO:0042551)2.36590802
138exploration behavior (GO:0035640)2.36440471
139positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.35986501
140positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.35900563
141regulation of T-helper 2 cell differentiation (GO:0045628)2.35323512
142positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.34411526
143glutamate secretion (GO:0014047)2.33691335
144neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.32630017
145positive regulation of interleukin-17 production (GO:0032740)2.31468851
146synaptic vesicle exocytosis (GO:0016079)2.30315915
147negative regulation of synaptic transmission, GABAergic (GO:0032229)2.28960248
148positive regulation of T cell cytokine production (GO:0002726)2.27488488
149regulation of memory T cell differentiation (GO:0043380)2.24013660
150response to redox state (GO:0051775)2.23642615
151cytoplasmic mRNA processing body assembly (GO:0033962)2.23634286
152membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.23584748
153peripheral nervous system axon ensheathment (GO:0032292)2.23264461
154myelination in peripheral nervous system (GO:0022011)2.23264461
155gamma-aminobutyric acid transport (GO:0015812)2.21965038
156regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.21319217
157regulation of platelet aggregation (GO:0090330)2.20167867
158regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.19714571
159regulation of glutamate receptor signaling pathway (GO:1900449)2.19572129
160neuronal ion channel clustering (GO:0045161)2.19498263
161cellular response to epinephrine stimulus (GO:0071872)2.17222498
162gamma-aminobutyric acid signaling pathway (GO:0007214)2.16199235
163regulation of protein polyubiquitination (GO:1902914)2.15876543
164regulation of homotypic cell-cell adhesion (GO:0034110)2.15787220
165Golgi to endosome transport (GO:0006895)2.15515105
166cyclic nucleotide catabolic process (GO:0009214)2.14849602
167positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.14311861
168startle response (GO:0001964)2.13473862
169long-term memory (GO:0007616)2.13325929
170positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.13255690
171glycerophospholipid catabolic process (GO:0046475)2.12922196
172eye photoreceptor cell differentiation (GO:0001754)2.12602365
173photoreceptor cell differentiation (GO:0046530)2.12602365
174regulation of synaptic transmission, glutamatergic (GO:0051966)2.12570588
175regulation of excitatory postsynaptic membrane potential (GO:0060079)2.11269765
176protein targeting to Golgi (GO:0000042)2.11106319
177positive regulation of heat generation (GO:0031652)2.09333361
178import into cell (GO:0098657)2.08814152
179regulation of neuronal synaptic plasticity (GO:0048168)2.06317041
180negative regulation of synaptic transmission (GO:0050805)2.04371402
181modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.04269949
182positive regulation by organism of defense response of other organism involved in symbiotic interact2.04269949
183modulation by symbiont of host immune response (GO:0052553)2.04269949
184positive regulation by symbiont of host defense response (GO:0052509)2.04269949
185modulation by symbiont of host defense response (GO:0052031)2.04269949
186modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.04269949
187negative regulation of exocytosis (GO:0045920)2.03720070
188response to epinephrine (GO:0071871)2.03566701
189membrane hyperpolarization (GO:0060081)2.02940706
190regulation of beta-amyloid formation (GO:1902003)2.02722893
191vocalization behavior (GO:0071625)2.01845173
192regulation of postsynaptic membrane potential (GO:0060078)2.01553222
193response to auditory stimulus (GO:0010996)2.01388636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.27610840
2GBX2_23144817_ChIP-Seq_PC3_Human3.25187117
3VDR_22108803_ChIP-Seq_LS180_Human2.61749811
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.43392289
5EZH2_22144423_ChIP-Seq_EOC_Human2.35998366
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21019405
7EWS_26573619_Chip-Seq_HEK293_Human2.16171274
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14701483
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.03662035
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98605509
11POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96783131
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91489965
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88286071
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87316032
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86288342
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86163102
17AR_21572438_ChIP-Seq_LNCaP_Human1.82777875
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82087998
19SMAD4_21799915_ChIP-Seq_A2780_Human1.79431251
20SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78644871
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77057851
22DROSHA_22980978_ChIP-Seq_HELA_Human1.75970300
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75030559
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70012908
25P300_19829295_ChIP-Seq_ESCs_Human1.69977047
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66561955
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64165041
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63338914
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61199164
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.59538506
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58007322
32TAF15_26573619_Chip-Seq_HEK293_Human1.57650594
33STAT3_23295773_ChIP-Seq_U87_Human1.57489895
34BCAT_22108803_ChIP-Seq_LS180_Human1.56101976
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53906571
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53882959
37TP53_16413492_ChIP-PET_HCT116_Human1.49650240
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49348400
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49348400
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48366134
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46968979
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.45312980
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45292521
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45292521
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.44659084
46IRF1_19129219_ChIP-ChIP_H3396_Human1.43574434
47CBP_20019798_ChIP-Seq_JUKART_Human1.42470629
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42470629
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42380811
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41106643
51ER_23166858_ChIP-Seq_MCF-7_Human1.40455458
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40274361
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.39824161
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.38783516
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38617419
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36103570
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.34754041
58TCF4_23295773_ChIP-Seq_U87_Human1.34732841
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34718610
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33257369
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31203245
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31068736
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29982713
64IGF1R_20145208_ChIP-Seq_DFB_Human1.28958247
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.28835833
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28259743
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.26832861
68AR_25329375_ChIP-Seq_VCAP_Human1.26747308
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26577555
70REST_21632747_ChIP-Seq_MESCs_Mouse1.26291906
71AHR_22903824_ChIP-Seq_MCF-7_Human1.25864505
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.25567353
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.23735466
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23563474
75TCF4_22108803_ChIP-Seq_LS180_Human1.23403288
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23402613
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.23350645
78RNF2_27304074_Chip-Seq_NSC_Mouse1.23331376
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.23050310
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.23046059
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22912857
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.21879460
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21582646
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21582646
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.21532765
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21247259
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17632289
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15989262
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15347540
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15292405
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15158398
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.14961524
93P53_22387025_ChIP-Seq_ESCs_Mouse1.14754373
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.14708737
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.13458235
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.13389323
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.13209825
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.13051261
99SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12813836
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12768959
101RUNX2_22187159_ChIP-Seq_PCA_Human1.11659623
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11548086
103RARB_27405468_Chip-Seq_BRAIN_Mouse1.11300299
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11197023
105FUS_26573619_Chip-Seq_HEK293_Human1.11193034
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.10111145
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.10048788
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09289948
109TP53_22573176_ChIP-Seq_HFKS_Human1.08936787
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08908853
111TP53_18474530_ChIP-ChIP_U2OS_Human1.08629447
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08358788
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07939033
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07819444
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07632172
116VDR_24787735_ChIP-Seq_THP-1_Human1.07134948
117IRF8_27001747_Chip-Seq_BMDM_Mouse1.06956525
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06716779
119KDM2B_26808549_Chip-Seq_REH_Human1.06245737
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.06181670
121STAT3_18555785_Chip-Seq_ESCs_Mouse1.06014523
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05553421
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05395536
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05240000
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05046672
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04399790
127P300_18555785_Chip-Seq_ESCs_Mouse1.04325770
128AR_19668381_ChIP-Seq_PC3_Human1.03748339
129SOX2_19829295_ChIP-Seq_ESCs_Human1.03473721
130NANOG_19829295_ChIP-Seq_ESCs_Human1.03473721
131RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03243347
132SOX2_18555785_Chip-Seq_ESCs_Mouse1.02771591
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01216973
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01092909
135FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00736562
136CRX_20693478_ChIP-Seq_RETINA_Mouse1.00474154
137RXR_22108803_ChIP-Seq_LS180_Human1.00444465
138HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98544055
139FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95444401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.31146208
2MP0004859_abnormal_synaptic_plasticity3.82468373
3MP0003880_abnormal_central_pattern3.29109367
4MP0009046_muscle_twitch3.04449201
5MP0000920_abnormal_myelination2.83535482
6MP0003195_calcinosis2.77342679
7MP0003690_abnormal_glial_cell2.57579112
8MP0002064_seizures2.53849041
9MP0005171_absent_coat_pigmentation2.53633048
10MP0003635_abnormal_synaptic_transmissio2.52442308
11MP0003172_abnormal_lysosome_physiology2.40695085
12MP0001486_abnormal_startle_reflex2.38021092
13MP0008877_abnormal_DNA_methylation2.37738650
14MP0000427_abnormal_hair_cycle2.36622509
15MP0009745_abnormal_behavioral_response2.34859979
16MP0004270_analgesia2.26519504
17MP0003646_muscle_fatigue2.20006177
18MP0002272_abnormal_nervous_system2.19956467
19MP0008057_abnormal_DNA_replication2.15873458
20MP0002102_abnormal_ear_morphology2.08433567
21MP0004043_abnormal_pH_regulation2.08292883
22MP0002063_abnormal_learning/memory/cond2.04013766
23MP0000383_abnormal_hair_follicle2.00625025
24MP0002572_abnormal_emotion/affect_behav1.97749170
25MP0002734_abnormal_mechanical_nocicepti1.97339286
26MP0004510_myositis1.94488811
27MP0003787_abnormal_imprinting1.92077520
28MP0005646_abnormal_pituitary_gland1.83955919
29MP0005310_abnormal_salivary_gland1.82499881
30MP0000778_abnormal_nervous_system1.82239018
31MP0000631_abnormal_neuroendocrine_gland1.74587241
32MP0004742_abnormal_vestibular_system1.74000957
33MP0001440_abnormal_grooming_behavior1.73319251
34MP0003045_fibrosis1.71889913
35MP0001501_abnormal_sleep_pattern1.70347823
36MP0002928_abnormal_bile_duct1.70032555
37MP0002067_abnormal_sensory_capabilities1.68790552
38MP0005423_abnormal_somatic_nervous1.65168987
39MP0001968_abnormal_touch/_nociception1.63083273
40MP0001299_abnormal_eye_distance/1.60426805
41MP0002638_abnormal_pupillary_reflex1.56777499
42MP0002837_dystrophic_cardiac_calcinosis1.56502478
43MP0005551_abnormal_eye_electrophysiolog1.56140339
44MP0003890_abnormal_embryonic-extraembry1.55378938
45MP0004145_abnormal_muscle_electrophysio1.54589532
46MP0002163_abnormal_gland_morphology1.54129564
47MP0005409_darkened_coat_color1.52826776
48MP0005645_abnormal_hypothalamus_physiol1.50697700
49MP0003632_abnormal_nervous_system1.48679276
50MP0003634_abnormal_glial_cell1.48300061
51MP0008569_lethality_at_weaning1.47736148
52MP0001502_abnormal_circadian_rhythm1.47476453
53MP0003183_abnormal_peptide_metabolism1.46165692
54MP0005386_behavior/neurological_phenoty1.45953183
55MP0004924_abnormal_behavior1.45953183
56MP0001984_abnormal_olfaction1.44274679
57MP0001835_abnormal_antigen_presentation1.43134620
58MP0006072_abnormal_retinal_apoptosis1.42403925
59MP0004142_abnormal_muscle_tone1.42172179
60MP0006082_CNS_inflammation1.39633323
61MP0005379_endocrine/exocrine_gland_phen1.39473431
62MP0000015_abnormal_ear_pigmentation1.38360408
63MP0004130_abnormal_muscle_cell1.36902637
64MP0001970_abnormal_pain_threshold1.36082386
65MP0006276_abnormal_autonomic_nervous1.35204432
66MP0002148_abnormal_hypersensitivity_rea1.34647653
67MP0003633_abnormal_nervous_system1.32657145
68MP0005187_abnormal_penis_morphology1.32214388
69MP0002009_preneoplasia1.31886286
70MP0002229_neurodegeneration1.31661842
71MP0004885_abnormal_endolymph1.30262194
72MP0003631_nervous_system_phenotype1.29447856
73MP0003950_abnormal_plasma_membrane1.29364940
74MP0002735_abnormal_chemical_nociception1.28444199
75MP0001905_abnormal_dopamine_level1.27806799
76MP0008872_abnormal_physiological_respon1.25942358
77MP0009780_abnormal_chondrocyte_physiolo1.25327367
78MP0002090_abnormal_vision1.23487330
79MP0002736_abnormal_nociception_after1.23301958
80MP0004133_heterotaxia1.23014402
81MP0001790_abnormal_immune_system1.22041168
82MP0005387_immune_system_phenotype1.22041168
83MP0002095_abnormal_skin_pigmentation1.21815718
84MP0002653_abnormal_ependyma_morphology1.20030360
85MP0002938_white_spotting1.18431183
86MP0002882_abnormal_neuron_morphology1.16785975
87MP0002733_abnormal_thermal_nociception1.16206588
88MP0001177_atelectasis1.13397705
89MP0010678_abnormal_skin_adnexa1.11828965
90MP0010386_abnormal_urinary_bladder1.11167745
91MP0004858_abnormal_nervous_system1.10680866
92MP0006292_abnormal_olfactory_placode1.08995244
93MP0000955_abnormal_spinal_cord1.08254270
94MP0004215_abnormal_myocardial_fiber1.07469342
95MP0005058_abnormal_lysosome_morphology1.05790092
96MP0008961_abnormal_basal_metabolism1.05686607
97MP0002557_abnormal_social/conspecific_i1.02595141
98MP0002419_abnormal_innate_immunity1.01555408
99MP0005167_abnormal_blood-brain_barrier1.00219685
100MP0002066_abnormal_motor_capabilities/c0.99830772
101MP0003937_abnormal_limbs/digits/tail_de0.99094883
102MP0005000_abnormal_immune_tolerance0.98843195
103MP0005389_reproductive_system_phenotype0.97178713
104MP0000647_abnormal_sebaceous_gland0.95524913
105MP0001324_abnormal_eye_pigmentation0.95271613
106MP0003121_genomic_imprinting0.95058486
107MP0002160_abnormal_reproductive_system0.94680635
108MP0001986_abnormal_taste_sensitivity0.93440339
109MP0002752_abnormal_somatic_nervous0.93233684
110MP0004134_abnormal_chest_morphology0.92933567
111MP0002332_abnormal_exercise_endurance0.92931592
112MP0002184_abnormal_innervation0.92590472
113MP0002277_abnormal_respiratory_mucosa0.92447588
114MP0001188_hyperpigmentation0.90928754
115MP0001529_abnormal_vocalization0.90841436
116MP0009697_abnormal_copulation0.88281171
117MP0003091_abnormal_cell_migration0.88134072
118MP0009785_altered_susceptibility_to0.87982292
119MP0002234_abnormal_pharynx_morphology0.87781251
120MP0002822_catalepsy0.87094263
121MP0002876_abnormal_thyroid_physiology0.86843139
122MP0000538_abnormal_urinary_bladder0.86820344
123MP0003136_yellow_coat_color0.86238913
124MP0003252_abnormal_bile_duct0.86049788
125MP0000230_abnormal_systemic_arterial0.84553674
126MP0002751_abnormal_autonomic_nervous0.84172260
127MP0004484_altered_response_of0.84147851
128MP0005535_abnormal_body_temperature0.83728580
129MP0004811_abnormal_neuron_physiology0.83575111
130MP0005391_vision/eye_phenotype0.83097389
131MP0000026_abnormal_inner_ear0.82228110
132MP0008875_abnormal_xenobiotic_pharmacok0.82123210
133MP0002998_abnormal_bone_remodeling0.81685399
134MP0001346_abnormal_lacrimal_gland0.81017460
135MP0001963_abnormal_hearing_physiology0.80301267
136MP0000372_irregular_coat_pigmentation0.79554520
137MP0004147_increased_porphyrin_level0.79016947
138MP0005671_abnormal_response_to0.77159742
139MP0005174_abnormal_tail_pigmentation0.76058938
140MP0001919_abnormal_reproductive_system0.75670459
141MP0005195_abnormal_posterior_eye0.75009471
142MP0002168_other_aberrant_phenotype0.74482531
143MP0001348_abnormal_lacrimal_gland0.74426507
144MP0003698_abnormal_male_reproductive0.74267806
145MP0005253_abnormal_eye_physiology0.73931302
146MP0008775_abnormal_heart_ventricle0.73825839
147MP0003119_abnormal_digestive_system0.73757196
148MP0005623_abnormal_meninges_morphology0.73545152
149MP0003943_abnormal_hepatobiliary_system0.72920907
150MP0001851_eye_inflammation0.72501221
151MP0000604_amyloidosis0.71462633
152MP0003075_altered_response_to0.71069424
153MP0001485_abnormal_pinna_reflex0.70447151

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.54298693
2Focal motor seizures (HP:0011153)4.21263857
3Molar tooth sign on MRI (HP:0002419)4.13481939
4Abnormality of midbrain morphology (HP:0002418)4.13481939
5Pancreatic fibrosis (HP:0100732)4.02600880
6Nephronophthisis (HP:0000090)3.99206631
7Febrile seizures (HP:0002373)3.96526580
8True hermaphroditism (HP:0010459)3.92827490
9Abnormality of the renal medulla (HP:0100957)3.62345136
10Epileptic encephalopathy (HP:0200134)3.55145990
11Abnormality of the renal cortex (HP:0011035)3.45603878
12Progressive cerebellar ataxia (HP:0002073)3.39270014
13Chronic hepatic failure (HP:0100626)3.34091244
14Tubular atrophy (HP:0000092)3.17553519
15Atonic seizures (HP:0010819)3.08156359
16Action tremor (HP:0002345)3.06542425
17Supranuclear gaze palsy (HP:0000605)3.04123869
18Focal seizures (HP:0007359)3.03384663
19Degeneration of the lateral corticospinal tracts (HP:0002314)3.03147396
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.03147396
21Gaze-evoked nystagmus (HP:0000640)3.02813777
22Slow saccadic eye movements (HP:0000514)3.00283444
23Type II lissencephaly (HP:0007260)2.89598473
24Scanning speech (HP:0002168)2.88105403
25Abnormality of the corticospinal tract (HP:0002492)2.87906100
26Thick nail (HP:0001805)2.85789149
27Sensory axonal neuropathy (HP:0003390)2.83032153
28Cystic liver disease (HP:0006706)2.81435539
29Attenuation of retinal blood vessels (HP:0007843)2.79795702
30Dysmetria (HP:0001310)2.79239840
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.75792823
32Absent/shortened dynein arms (HP:0200106)2.75792823
33Stomach cancer (HP:0012126)2.73140776
34Intention tremor (HP:0002080)2.69262712
35Inability to walk (HP:0002540)2.68584046
36Absent speech (HP:0001344)2.61352457
37Stomatitis (HP:0010280)2.58977652
38Widely spaced teeth (HP:0000687)2.57423150
39Neurofibrillary tangles (HP:0002185)2.55349364
40Broad-based gait (HP:0002136)2.54253083
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.52595772
42Abnormal hair whorl (HP:0010721)2.52369832
43Myokymia (HP:0002411)2.51406360
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46945126
45Abnormality of alanine metabolism (HP:0010916)2.46945126
46Hyperalaninemia (HP:0003348)2.46945126
47Onion bulb formation (HP:0003383)2.46035526
48Cerebellar dysplasia (HP:0007033)2.45879361
49Autoimmune thrombocytopenia (HP:0001973)2.44598378
50Dysdiadochokinesis (HP:0002075)2.43804115
51Drooling (HP:0002307)2.43162639
52Excessive salivation (HP:0003781)2.43162639
53Furrowed tongue (HP:0000221)2.38360550
54Abnormal drinking behavior (HP:0030082)2.37282606
55Polydipsia (HP:0001959)2.37282606
56Macroorchidism (HP:0000053)2.34647432
57Large for gestational age (HP:0001520)2.33357725
58Genetic anticipation (HP:0003743)2.29593708
59Clumsiness (HP:0002312)2.28717410
60Patellar aplasia (HP:0006443)2.27457583
61Lissencephaly (HP:0001339)2.24509862
62Blue irides (HP:0000635)2.23286969
63Decreased circulating renin level (HP:0003351)2.21789610
64Urinary bladder sphincter dysfunction (HP:0002839)2.21288878
65Birth length less than 3rd percentile (HP:0003561)2.20788519
66Postural instability (HP:0002172)2.20346517
67Renal cortical cysts (HP:0000803)2.19616447
68Progressive inability to walk (HP:0002505)2.17473808
69Congenital hepatic fibrosis (HP:0002612)2.17307785
70Abnormality of the nasal septum (HP:0000419)2.15399234
71Hypoplastic iliac wings (HP:0002866)2.15229768
72Bony spicule pigmentary retinopathy (HP:0007737)2.15101609
73Abnormality of incisor morphology (HP:0011063)2.14554371
74Spastic gait (HP:0002064)2.12228751
75Dialeptic seizures (HP:0011146)2.11984501
76Neoplasm of the adrenal cortex (HP:0100641)2.11005388
77Increased IgM level (HP:0003496)2.09294291
78Hyperventilation (HP:0002883)2.07920771
79Abnormality of the pons (HP:0007361)2.07827357
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07101916
81Partial agenesis of the corpus callosum (HP:0001338)2.07071979
82Absence seizures (HP:0002121)2.06961305
83Aplasia/Hypoplasia of the patella (HP:0006498)2.06247120
84Chorioretinal atrophy (HP:0000533)2.06172504
85Abolished electroretinogram (ERG) (HP:0000550)2.06036166
86Generalized tonic-clonic seizures (HP:0002069)2.05214776
87Aplasia/Hypoplasia of the tongue (HP:0010295)2.02466676
88Recurrent bacterial skin infections (HP:0005406)2.01776023
89Decreased central vision (HP:0007663)2.01455044
90Abnormal ciliary motility (HP:0012262)2.00795952
91Hypoplasia of the pons (HP:0012110)2.00672897
92Sclerocornea (HP:0000647)2.00180643
93Abnormal biliary tract physiology (HP:0012439)1.99775800
94Bile duct proliferation (HP:0001408)1.99775800
95Abnormal respiratory epithelium morphology (HP:0012253)1.99542018
96Abnormal respiratory motile cilium morphology (HP:0005938)1.99542018
97Abnormal rod and cone electroretinograms (HP:0008323)1.97416766
98Truncal ataxia (HP:0002078)1.96691373
99Hip dysplasia (HP:0001385)1.96319258
100Anencephaly (HP:0002323)1.95367228
101Vaginal atresia (HP:0000148)1.95121457
102Dyschromatopsia (HP:0007641)1.95020108
103Generalized hypopigmentation of hair (HP:0011358)1.94393563
104Tubulointerstitial nephritis (HP:0001970)1.93820059
105Lower limb muscle weakness (HP:0007340)1.92533302
106Recurrent abscess formation (HP:0002722)1.92164800
107Hemiparesis (HP:0001269)1.91066402
108Increased corneal curvature (HP:0100692)1.90483364
109Keratoconus (HP:0000563)1.90483364
110Mediastinal lymphadenopathy (HP:0100721)1.90256875
111Abnormality of salivation (HP:0100755)1.90199709
112Aqueductal stenosis (HP:0002410)1.89758559
113Postaxial foot polydactyly (HP:0001830)1.87695429
114Lower limb amyotrophy (HP:0007210)1.87108232
115Fair hair (HP:0002286)1.85233743
116Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83777029
117Congenital stationary night blindness (HP:0007642)1.82351890
118Arterial tortuosity (HP:0005116)1.81102923
119Submucous cleft hard palate (HP:0000176)1.80568007
120Progressive visual loss (HP:0000529)1.80277819
121Small hand (HP:0200055)1.79407272
122Highly arched eyebrow (HP:0002553)1.79128002
123Abnormality of the fingertips (HP:0001211)1.79117041
124Tubulointerstitial abnormality (HP:0001969)1.79067702
125Abnormality of the periventricular white matter (HP:0002518)1.78349968
126Depressed nasal tip (HP:0000437)1.78228618
127Parakeratosis (HP:0001036)1.78029618
128Male pseudohermaphroditism (HP:0000037)1.77533987
129Tented upper lip vermilion (HP:0010804)1.77107087
130Prostate neoplasm (HP:0100787)1.76931789
131Choroideremia (HP:0001139)1.76877648
132Polyuria (HP:0000103)1.75111271
133Abnormality of saccadic eye movements (HP:0000570)1.74967912
134Retrobulbar optic neuritis (HP:0100654)1.73899552
135Optic neuritis (HP:0100653)1.73899552
136Bulbous nose (HP:0000414)1.72931825
137Thyroiditis (HP:0100646)1.72696679
138Papillary thyroid carcinoma (HP:0002895)1.72320258
139Colon cancer (HP:0003003)1.72069062
140Relative macrocephaly (HP:0004482)1.72010275
141Concave nail (HP:0001598)1.70455563
142Gait imbalance (HP:0002141)1.70234140
143Protruding tongue (HP:0010808)1.69873049
144Pulmonary artery stenosis (HP:0004415)1.69335348
145Congenital sensorineural hearing impairment (HP:0008527)1.69302779
146Short foot (HP:0001773)1.68661613
147Dandy-Walker malformation (HP:0001305)1.67347197
148Hypoplastic labia majora (HP:0000059)1.66541952
149Hypoplastic ischia (HP:0003175)1.66196072
150Intestinal atresia (HP:0011100)1.64927051
151Absent frontal sinuses (HP:0002688)1.64640113
152Pachygyria (HP:0001302)1.64123668
153Peripheral hypomyelination (HP:0007182)1.63959341
154Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.63662833
155Increased neuronal autofluorescent lipopigment (HP:0002074)1.62945103
156Open mouth (HP:0000194)1.61916866
157Abnormality of the ischium (HP:0003174)1.60785462
158Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.60650229
159Congenital primary aphakia (HP:0007707)1.59309383
160Cerebral inclusion bodies (HP:0100314)1.57901838
161Deeply set eye (HP:0000490)1.57404621
162Cupped ear (HP:0000378)1.55902599
163Mask-like facies (HP:0000298)1.54156313
164Vascular tortuosity (HP:0004948)1.53340520
165Abnormal auditory evoked potentials (HP:0006958)1.53225840
166Poor coordination (HP:0002370)1.52970858
167Epileptiform EEG discharges (HP:0011182)1.52532163
168Decreased motor nerve conduction velocity (HP:0003431)1.52450862
169Medial flaring of the eyebrow (HP:0010747)1.52399947
170Genital tract atresia (HP:0001827)1.49870509
171Mutism (HP:0002300)1.49837698
172Nephrogenic diabetes insipidus (HP:0009806)1.49680291
173Increased cerebral lipofuscin (HP:0011813)1.49417073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B3.01183630
2TNIK2.71931778
3RIPK42.42168173
4MAP3K142.38948611
5NTRK32.36341860
6MAP3K132.15453585
7ZAK2.13285674
8PBK2.11305345
9EPHA42.03259479
10BMPR22.00191875
11WNK41.99230896
12PNCK1.94766139
13STK391.87692284
14WNK31.84434083
15GRK11.74475713
16PKN11.73778095
17FES1.72863293
18WNK11.72381122
19MKNK21.66835034
20BCR1.62856527
21PRPF4B1.62283085
22CASK1.61281677
23MAP3K41.55918480
24MAP2K71.54287457
25SGK21.52711039
26SGK4941.48015573
27SGK2231.48015573
28NEK61.44041464
29MAP4K21.43154038
30IRAK41.38304413
31EPHB11.37589512
32TLK11.36634432
33MAPK131.33009463
34OXSR11.32457397
35TYRO31.31303322
36MAP3K91.30423050
37CAMK1G1.29093129
38INSRR1.29084161
39NUAK11.27445049
40TGFBR11.22806765
41PLK21.22207819
42AKT31.21195020
43SGK31.18014029
44YES11.16548322
45JAK31.13533457
46MAPK151.12995847
47JAK11.11269720
48FRK1.10660272
49ADRBK11.10439791
50NLK1.09338449
51PRKCH1.08906881
52NTRK11.06839794
53CDK121.05119335
54CAMK1D1.04746369
55IRAK21.02044018
56DAPK21.00927997
57BRD41.00347768
58ERBB31.00204296
59PIK3CA0.99318554
60IKBKE0.98486844
61IKBKB0.97153170
62PRKD30.95545650
63SGK10.91236956
64GRK70.90880589
65MAPKAPK50.90822443
66LATS10.90097438
67SIK30.89931231
68SIK20.89164526
69PAK60.87507614
70FGFR20.86899584
71PDGFRB0.86316312
72NTRK20.84851349
73PRKCQ0.83258659
74STK38L0.79961027
75PTK2B0.77273811
76FGR0.76339135
77MARK10.75744074
78PRKCE0.74544700
79TEC0.73875964
80MARK20.73661699
81CHUK0.72719888
82CDK50.72017466
83TXK0.71106774
84CDK30.70674163
85FGFR30.69699859
86TAOK30.69520607
87STK110.68789218
88IRAK30.68254032
89DMPK0.68042712
90IRAK10.67555159
91CAMK2A0.67146198
92CSK0.61924381
93MKNK10.61336667
94MAP2K40.60911600
95BRSK20.60753663
96TYK20.60675986
97KSR20.60499856
98MAPK70.60181847
99GRK50.59699729
100PRKCG0.59636624
101MINK10.59513743
102STK30.59451160
103ERBB40.59303339
104PRKAA20.59065620
105HCK0.57460180
106ADRBK20.54652781
107WEE10.54647601
108MAP3K20.54524087
109PINK10.54125111
110ERBB20.53752967
111CAMK10.53416342
112PLK40.53411129
113CAMK2D0.53097919
114PAK30.52500895
115CAMK40.52481478
116CSNK1A1L0.52376013
117MAPK100.51765152
118PRKG10.50797604
119FYN0.49673828
120MAP3K70.49530348
121PDK10.49180496
122CAMK2B0.48472539
123OBSCN0.48388454
124TBK10.47851985
125EPHA30.45980554
126CSNK1G10.45555327
127PRKAA10.45370345
128BMPR1B0.45021926
129PDPK10.44434330
130CLK10.43929920
131NEK20.43423722
132PRKD20.43253268
133MELK0.43202013
134PIK3CG0.42992678
135CSNK1G20.42818443
136CAMKK20.42351346
137STK380.42032736
138KIT0.41902146
139TRPM70.41805448
140DYRK1A0.40859880
141DYRK20.39545160
142RPS6KA50.39169521
143MAP2K60.37852296
144RPS6KA60.36350876
145CSNK1D0.34060862
146PRKCZ0.33421565
147TNK20.32557055
148CAMKK10.32533512
149ATM0.30878794
150ATR0.29742765

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.55181998
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40273873
3Linoleic acid metabolism_Homo sapiens_hsa005912.36236827
4Butanoate metabolism_Homo sapiens_hsa006502.33963246
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00029128
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94428771
7Nicotine addiction_Homo sapiens_hsa050331.92508719
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.85005691
9Glutamatergic synapse_Homo sapiens_hsa047241.84611080
10Synaptic vesicle cycle_Homo sapiens_hsa047211.73224566
11ABC transporters_Homo sapiens_hsa020101.71892102
12Morphine addiction_Homo sapiens_hsa050321.70270215
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65920702
14GABAergic synapse_Homo sapiens_hsa047271.65615963
15Graft-versus-host disease_Homo sapiens_hsa053321.63694683
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.62705661
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60693177
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.58530968
19Allograft rejection_Homo sapiens_hsa053301.58355882
20Fanconi anemia pathway_Homo sapiens_hsa034601.55923642
21Homologous recombination_Homo sapiens_hsa034401.55222648
22Rheumatoid arthritis_Homo sapiens_hsa053231.54836040
23Type I diabetes mellitus_Homo sapiens_hsa049401.53766101
24Circadian entrainment_Homo sapiens_hsa047131.53109988
25Tryptophan metabolism_Homo sapiens_hsa003801.50884470
26Selenocompound metabolism_Homo sapiens_hsa004501.49598698
27Serotonergic synapse_Homo sapiens_hsa047261.46833136
28Cholinergic synapse_Homo sapiens_hsa047251.40365857
29Type II diabetes mellitus_Homo sapiens_hsa049301.39223752
30Olfactory transduction_Homo sapiens_hsa047401.37552566
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36248904
32Phototransduction_Homo sapiens_hsa047441.36030973
33Collecting duct acid secretion_Homo sapiens_hsa049661.35543579
34Long-term potentiation_Homo sapiens_hsa047201.34185467
35Long-term depression_Homo sapiens_hsa047301.32307819
36Ether lipid metabolism_Homo sapiens_hsa005651.30824322
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.29871328
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27812659
39Dorso-ventral axis formation_Homo sapiens_hsa043201.25779510
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24426379
41Salivary secretion_Homo sapiens_hsa049701.24338008
42African trypanosomiasis_Homo sapiens_hsa051431.22173863
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17867098
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17155484
45Dopaminergic synapse_Homo sapiens_hsa047281.15908407
46Basal transcription factors_Homo sapiens_hsa030221.15552633
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15533233
48Insulin secretion_Homo sapiens_hsa049111.13944057
49Chemokine signaling pathway_Homo sapiens_hsa040621.12490069
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10710509
51Amphetamine addiction_Homo sapiens_hsa050311.07764624
52Autoimmune thyroid disease_Homo sapiens_hsa053201.07715545
53Circadian rhythm_Homo sapiens_hsa047101.06800149
54Taste transduction_Homo sapiens_hsa047421.05605829
55Steroid biosynthesis_Homo sapiens_hsa001001.05515042
56Caffeine metabolism_Homo sapiens_hsa002321.04943328
57Malaria_Homo sapiens_hsa051441.03419665
58Osteoclast differentiation_Homo sapiens_hsa043801.03230668
59Lysine degradation_Homo sapiens_hsa003100.99240522
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.98381258
61Renin secretion_Homo sapiens_hsa049240.97563586
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.97439493
63Axon guidance_Homo sapiens_hsa043600.97211860
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97107994
65TNF signaling pathway_Homo sapiens_hsa046680.95266394
66Cocaine addiction_Homo sapiens_hsa050300.94898865
67cAMP signaling pathway_Homo sapiens_hsa040240.93421597
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91337710
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90520358
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90243688
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.89985450
72Calcium signaling pathway_Homo sapiens_hsa040200.89613878
73Oxytocin signaling pathway_Homo sapiens_hsa049210.89403877
74GnRH signaling pathway_Homo sapiens_hsa049120.88993665
75ErbB signaling pathway_Homo sapiens_hsa040120.88748571
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.88601966
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87522428
78Phagosome_Homo sapiens_hsa041450.86429545
79Tuberculosis_Homo sapiens_hsa051520.85759871
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.85510162
81Inositol phosphate metabolism_Homo sapiens_hsa005620.85105954
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85091292
83Ovarian steroidogenesis_Homo sapiens_hsa049130.84299831
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.84134481
85Gastric acid secretion_Homo sapiens_hsa049710.83700293
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83402471
87Regulation of autophagy_Homo sapiens_hsa041400.83323974
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82966917
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81183042
90Staphylococcus aureus infection_Homo sapiens_hsa051500.80685045
91B cell receptor signaling pathway_Homo sapiens_hsa046620.80477022
92Vibrio cholerae infection_Homo sapiens_hsa051100.80283377
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79133477
94MAPK signaling pathway_Homo sapiens_hsa040100.77599548
95Propanoate metabolism_Homo sapiens_hsa006400.77512334
96Choline metabolism in cancer_Homo sapiens_hsa052310.77001850
97Sphingolipid metabolism_Homo sapiens_hsa006000.76215800
98RNA degradation_Homo sapiens_hsa030180.76161136
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75574667
100Measles_Homo sapiens_hsa051620.75109616
101Peroxisome_Homo sapiens_hsa041460.75015093
102Glycerolipid metabolism_Homo sapiens_hsa005610.74795393
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74437838
104Ras signaling pathway_Homo sapiens_hsa040140.74152770
105Leishmaniasis_Homo sapiens_hsa051400.72247713
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71940600
107Influenza A_Homo sapiens_hsa051640.70311838
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70054620
109Retinol metabolism_Homo sapiens_hsa008300.68579021
110Salmonella infection_Homo sapiens_hsa051320.68534686
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68155178
112Hedgehog signaling pathway_Homo sapiens_hsa043400.67615499
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66378446
114Glioma_Homo sapiens_hsa052140.65362464
115Basal cell carcinoma_Homo sapiens_hsa052170.65320282
116Prion diseases_Homo sapiens_hsa050200.65054714
117Arachidonic acid metabolism_Homo sapiens_hsa005900.65052632
118Pertussis_Homo sapiens_hsa051330.64939541
119T cell receptor signaling pathway_Homo sapiens_hsa046600.64855652
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64128767
121Renal cell carcinoma_Homo sapiens_hsa052110.63885405
122Chemical carcinogenesis_Homo sapiens_hsa052040.63829558
123Lysosome_Homo sapiens_hsa041420.63816834
124Fatty acid biosynthesis_Homo sapiens_hsa000610.63664060
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.62903431
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62747330
127RNA polymerase_Homo sapiens_hsa030200.62732566
128FoxO signaling pathway_Homo sapiens_hsa040680.62256496
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61520744
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61252314
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61130070
132Histidine metabolism_Homo sapiens_hsa003400.58902293
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58444316
134TGF-beta signaling pathway_Homo sapiens_hsa043500.57897034
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.56104298
136Dilated cardiomyopathy_Homo sapiens_hsa054140.56034405
137Asthma_Homo sapiens_hsa053100.55594888
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54753884
139Pancreatic secretion_Homo sapiens_hsa049720.52457833
140Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51908477
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51890904
142Prolactin signaling pathway_Homo sapiens_hsa049170.51795501
143Platelet activation_Homo sapiens_hsa046110.51006113
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46287436
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.44406259
146Melanoma_Homo sapiens_hsa052180.42751949
147beta-Alanine metabolism_Homo sapiens_hsa004100.41715344
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.41612154
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39960802
150Hippo signaling pathway_Homo sapiens_hsa043900.38224431
151Mineral absorption_Homo sapiens_hsa049780.36895187
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32597082
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32025246
154Vitamin digestion and absorption_Homo sapiens_hsa049770.28503983

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