AGO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1production of molecular mediator involved in inflammatory response (GO:0002532)6.87440623
2positive regulation of gamma-delta T cell activation (GO:0046645)5.93036523
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.58007038
4negative regulation of cell killing (GO:0031342)5.58007038
5detection of molecule of bacterial origin (GO:0032490)5.22218987
6cellular extravasation (GO:0045123)4.94147295
7regulation of B cell receptor signaling pathway (GO:0050855)4.81319342
8positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.60989570
9detection of external biotic stimulus (GO:0098581)4.40398069
10regulation of gamma-delta T cell activation (GO:0046643)4.26496171
11negative regulation of interleukin-12 production (GO:0032695)4.10862966
12negative regulation of lymphocyte mediated immunity (GO:0002707)4.00763154
13leukocyte migration involved in inflammatory response (GO:0002523)4.00472638
14antigen processing and presentation of endogenous antigen (GO:0019883)3.97172413
15detection of biotic stimulus (GO:0009595)3.89696812
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.89515098
17positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.88315266
18regulation of gamma-delta T cell differentiation (GO:0045586)3.83819687
19microglial cell activation (GO:0001774)3.81295763
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.63005760
21activated T cell proliferation (GO:0050798)3.60383353
22negative regulation of T cell mediated immunity (GO:0002710)3.58513161
23leukocyte aggregation (GO:0070486)3.57256329
24respiratory burst (GO:0045730)3.55318561
25nerve growth factor signaling pathway (GO:0038180)3.53666327
26myeloid leukocyte mediated immunity (GO:0002444)3.49034754
27B cell receptor signaling pathway (GO:0050853)3.44310837
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.43824893
29response to interleukin-15 (GO:0070672)3.39819880
30negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.39209408
31negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.36795450
32positive regulation of mast cell activation (GO:0033005)3.34709368
33negative regulation of leukocyte mediated immunity (GO:0002704)3.32222967
34regulation of phospholipase A2 activity (GO:0032429)3.25162530
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24471988
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24471988
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.24471988
38modulation by symbiont of host immune response (GO:0052553)3.24471988
39positive regulation by symbiont of host defense response (GO:0052509)3.24471988
40modulation by symbiont of host defense response (GO:0052031)3.24471988
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.22691733
42positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.16640252
43G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.14992230
44negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.12477147
45ceramide catabolic process (GO:0046514)3.12142224
46regulation of tolerance induction (GO:0002643)3.07154916
47regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.06557834
48negative regulation of T-helper cell differentiation (GO:0045623)3.06257002
49negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.06257002
50response to muramyl dipeptide (GO:0032495)3.05756664
51regulation of myeloid leukocyte mediated immunity (GO:0002886)3.05347143
52negative thymic T cell selection (GO:0045060)3.03763941
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.00723377
54negative T cell selection (GO:0043383)3.00357896
55regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.00341207
56establishment of skin barrier (GO:0061436)2.99598775
57regulation of B cell differentiation (GO:0045577)2.99513107
58cellular response to interleukin-15 (GO:0071350)2.98883671
59positive T cell selection (GO:0043368)2.98828088
60dendritic cell migration (GO:0036336)2.98234297
61positive regulation of B cell differentiation (GO:0045579)2.93958798
62positive thymic T cell selection (GO:0045059)2.92744105
63positive regulation of cellular amide metabolic process (GO:0034250)2.92250002
64negative regulation of adaptive immune response (GO:0002820)2.89709351
65startle response (GO:0001964)2.89382150
66ionotropic glutamate receptor signaling pathway (GO:0035235)2.89297853
67glycosphingolipid catabolic process (GO:0046479)2.89247767
68negative regulation of erythrocyte differentiation (GO:0045647)2.88899210
69regulation of leukocyte degranulation (GO:0043300)2.88636023
70immunoglobulin mediated immune response (GO:0016064)2.88409723
71negative regulation of B cell mediated immunity (GO:0002713)2.88040136
72negative regulation of immunoglobulin mediated immune response (GO:0002890)2.88040136
73positive regulation of tolerance induction (GO:0002645)2.87346998
74postsynaptic membrane organization (GO:0001941)2.85982801
75antigen processing and presentation via MHC class Ib (GO:0002475)2.84621847
76positive regulation of mast cell activation involved in immune response (GO:0033008)2.83234017
77positive regulation of mast cell degranulation (GO:0043306)2.83234017
78phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.83052228
79regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.79210998
80eosinophil chemotaxis (GO:0048245)2.78729711
81defense response to protozoan (GO:0042832)2.76462039
82regulation of macrophage cytokine production (GO:0010935)2.76061726
83leukocyte degranulation (GO:0043299)2.75444320
84regulation of T cell tolerance induction (GO:0002664)2.75428356
85neutrophil chemotaxis (GO:0030593)2.75339085
86positive regulation of toll-like receptor signaling pathway (GO:0034123)2.73871063
87hemidesmosome assembly (GO:0031581)2.71920732
88response to peptidoglycan (GO:0032494)2.71750834
89G-protein coupled receptor internalization (GO:0002031)2.71623564
90superoxide anion generation (GO:0042554)2.69595161
91presynaptic membrane assembly (GO:0097105)2.69476782
92neutrophil migration (GO:1990266)2.68141310
93glycolipid catabolic process (GO:0019377)2.66810271
94regulation of cellular amide metabolic process (GO:0034248)2.65892751
95regulation of interleukin-6 biosynthetic process (GO:0045408)2.64420044
96I-kappaB phosphorylation (GO:0007252)2.63952527
97cAMP catabolic process (GO:0006198)2.62548100
98response to host immune response (GO:0052572)2.60211326
99response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.60211326
100negative regulation of mast cell activation (GO:0033004)2.58914910
101macrophage activation involved in immune response (GO:0002281)2.58366179
102cilium or flagellum-dependent cell motility (GO:0001539)2.55518945
103negative regulation of dendrite development (GO:2000171)2.53132498
104detection of other organism (GO:0098543)2.50129145
105sphingolipid catabolic process (GO:0030149)2.49851483
106eosinophil migration (GO:0072677)2.49037558
107purinergic nucleotide receptor signaling pathway (GO:0035590)2.47134881
108negative regulation of dendrite morphogenesis (GO:0050774)2.46199646
109G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.45342563
110interleukin-1-mediated signaling pathway (GO:0070498)2.44436689
111neuron cell-cell adhesion (GO:0007158)2.42645649
112regulation of water loss via skin (GO:0033561)2.40564252
113regulation of mast cell activation (GO:0033003)2.40164813
114glutamate receptor signaling pathway (GO:0007215)2.40036107
115cyclic nucleotide catabolic process (GO:0009214)2.39915745
116regulation of interferon-beta biosynthetic process (GO:0045357)2.39705526
117regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.39454215
118pharyngeal system development (GO:0060037)2.37158219
119macrophage activation (GO:0042116)2.36397145
120neutrophil mediated immunity (GO:0002446)2.31978417
121positive regulation of respiratory burst (GO:0060267)2.30101444
122central nervous system projection neuron axonogenesis (GO:0021952)2.30053733
123regulation of germinal center formation (GO:0002634)2.29357949
124dendritic spine morphogenesis (GO:0060997)2.29342083
125germinal center formation (GO:0002467)2.28709846
126regulation of platelet aggregation (GO:0090330)2.28641047
127keratinocyte development (GO:0003334)2.28540830
128regulation of glutamate receptor signaling pathway (GO:1900449)2.27782633
129positive regulation of antigen processing and presentation (GO:0002579)2.26718256
130membrane lipid catabolic process (GO:0046466)2.26475384
131autophagic vacuole fusion (GO:0000046)2.23527869
132limb bud formation (GO:0060174)2.23141471
133detection of bacterium (GO:0016045)2.22871656
134neutrophil activation (GO:0042119)2.22318758
135positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.21489638
136synaptic transmission, glutamatergic (GO:0035249)2.20669475
137regulation of mast cell activation involved in immune response (GO:0033006)2.18844332
138positive regulation of CREB transcription factor activity (GO:0032793)2.18625525
139response to host (GO:0075136)2.18306299
140response to host defenses (GO:0052200)2.18306299
141response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.18306299
142purinergic receptor signaling pathway (GO:0035587)2.18153022
143mitotic cell cycle arrest (GO:0071850)2.17503963
144presynaptic membrane organization (GO:0097090)2.17254646
145regulation of short-term neuronal synaptic plasticity (GO:0048172)2.16976448
146regulation of cell proliferation involved in kidney development (GO:1901722)2.15130584
147neutrophil activation involved in immune response (GO:0002283)2.12099609
148organelle membrane fusion (GO:0090174)2.11949198
149negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.11816568
150regulation of dendritic cell antigen processing and presentation (GO:0002604)2.10505452
151neurotransmitter-gated ion channel clustering (GO:0072578)2.09717430
152regulation of timing of cell differentiation (GO:0048505)2.09258355
153regulation of vesicle fusion (GO:0031338)2.08833479
154membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.08729948
155granulocyte activation (GO:0036230)2.07822509
156histone H3-K4 trimethylation (GO:0080182)2.07791257
157Rac protein signal transduction (GO:0016601)2.07427907
158sympathetic nervous system development (GO:0048485)2.06816992
159vocalization behavior (GO:0071625)2.06514973
160regulation of mast cell degranulation (GO:0043304)2.05538413
161oligosaccharide catabolic process (GO:0009313)2.04680785
162central nervous system neuron axonogenesis (GO:0021955)2.04586650
163cerebral cortex radially oriented cell migration (GO:0021799)2.04517342
164lipoxygenase pathway (GO:0019372)2.03613810
165positive regulation of vesicle fusion (GO:0031340)2.02228714
166keratinocyte proliferation (GO:0043616)2.01373206
167pigmentation (GO:0043473)1.99043819
168myeloid cell activation involved in immune response (GO:0002275)1.98164286
169desmosome organization (GO:0002934)1.98012022
170glucosamine-containing compound catabolic process (GO:1901072)1.97691360
171energy homeostasis (GO:0097009)1.97083457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.83866914
2EZH2_22144423_ChIP-Seq_EOC_Human3.69115816
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.63686626
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97109250
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81660569
6GBX2_23144817_ChIP-Seq_PC3_Human2.80599563
7RUNX_20019798_ChIP-Seq_JUKART_Human2.80047480
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.77842633
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70194760
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39683651
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38032494
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31279288
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23084340
14SPI1_23127762_ChIP-Seq_K562_Human2.21471111
15SCL_19346495_ChIP-Seq_HPC-7_Human2.20470280
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20232826
17VDR_24787735_ChIP-Seq_THP-1_Human2.16731122
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14721139
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.06946513
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04274617
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02577229
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00807916
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99644859
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97310116
25SPI1_23547873_ChIP-Seq_NB4_Human1.95231167
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93347784
27VDR_24763502_ChIP-Seq_THP-1_Human1.93104127
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.92101448
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89917701
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.89140468
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.85130798
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84734074
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82491341
34TAF15_26573619_Chip-Seq_HEK293_Human1.80248492
35MYB_26560356_Chip-Seq_TH2_Human1.74426870
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74254638
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74254638
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71492970
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.71284648
40DROSHA_22980978_ChIP-Seq_HELA_Human1.70460349
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.69368784
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.68123973
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67519944
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66423549
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65554003
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63264037
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.62558073
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62458586
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62085257
50AR_21572438_ChIP-Seq_LNCaP_Human1.59123862
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51818345
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48637670
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48429569
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47060810
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44697129
56GATA3_27048872_Chip-Seq_THYMUS_Human1.43885595
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42992693
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42292334
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42292334
60SMAD4_21799915_ChIP-Seq_A2780_Human1.42010718
61P300_19829295_ChIP-Seq_ESCs_Human1.40714763
62GATA1_22025678_ChIP-Seq_K562_Human1.39582138
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38345785
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37656617
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36770451
66MYB_26560356_Chip-Seq_TH1_Human1.36670774
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.36436380
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35118574
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35011382
70AHR_22903824_ChIP-Seq_MCF-7_Human1.34121601
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33066505
72MAF_26560356_Chip-Seq_TH1_Human1.32543784
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32515788
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32012257
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31521764
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.30652968
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.30578676
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30211736
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30208173
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.30054337
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.29929099
82AR_25329375_ChIP-Seq_VCAP_Human1.29927622
83PU_27001747_Chip-Seq_BMDM_Mouse1.29692279
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.28699641
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28692767
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28423787
87GATA3_26560356_Chip-Seq_TH2_Human1.27459516
88TP53_18474530_ChIP-ChIP_U2OS_Human1.27058297
89TCF7_22412390_ChIP-Seq_EML_Mouse1.26945410
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26725284
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25077556
92ESR1_20079471_ChIP-ChIP_T-47D_Human1.24839514
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.24303661
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.23617530
95VDR_21846776_ChIP-Seq_THP-1_Human1.23557443
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22956474
97RNF2_27304074_Chip-Seq_NSC_Mouse1.22718108
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.22650601
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22265764
100KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21869817
101UTX_26944678_Chip-Seq_JUKART_Human1.20922170
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20300270
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20238786
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19906967
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19399852
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19137233
107REST_21632747_ChIP-Seq_MESCs_Mouse1.18482604
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.17528863
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16220974
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16020420
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13757852
112TP53_16413492_ChIP-PET_HCT116_Human1.13540193
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11966994
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10457793
115P53_22387025_ChIP-Seq_ESCs_Mouse1.10348915
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.09920317
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.09849965
118SALL1_21062744_ChIP-ChIP_HESCs_Human1.09799267
119VDR_22108803_ChIP-Seq_LS180_Human1.09611934
120KDM2B_26808549_Chip-Seq_DND41_Human1.08467998
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08199914
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06039374
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.05861224
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05225554
125LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04819532
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04644789
127IRF8_27001747_Chip-Seq_BMDM_Mouse1.04107475
128RUNX2_22187159_ChIP-Seq_PCA_Human1.04097570
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03275416
130SMAD3_21741376_ChIP-Seq_HESCs_Human1.02888145
131STAT3_18555785_Chip-Seq_ESCs_Mouse1.02611896
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02596850
133PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02435387
134GATA1_19941826_ChIP-Seq_K562_Human1.02179849
135NMYC_18555785_Chip-Seq_ESCs_Mouse1.01736366
136P300_18555785_Chip-Seq_ESCs_Mouse1.01349844
137VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01102405
138CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00659726
139GATA2_19941826_ChIP-Seq_K562_Human1.00543689
140SMRT_27268052_Chip-Seq_Bcells_Human1.00541652
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00139285
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.99573273
143STAT3_23295773_ChIP-Seq_U87_Human0.98982584
144STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98959031
145BCAT_22108803_ChIP-Seq_LS180_Human0.98916676
146ER_23166858_ChIP-Seq_MCF-7_Human0.98785587
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98410260
148PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97388889
149ESR1_21235772_ChIP-Seq_MCF-7_Human0.96956879
150IRF8_22096565_ChIP-ChIP_GC-B_Human0.96892457
151PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96162877
152TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95921538
153RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95917578
154PU1_27457419_Chip-Seq_LIVER_Mouse0.95535925
155TP63_17297297_ChIP-ChIP_HaCaT_Human0.94132582
156STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93807052
157SOX2_18555785_Chip-Seq_ESCs_Mouse0.93524788
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93463728
159KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92740456
160GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91406890
161GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88641632
162KDM2B_26808549_Chip-Seq_JURKAT_Human0.87775989
163MYC_22102868_ChIP-Seq_BL_Human0.86973494
164CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86092763
165RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85887410
166GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85167912
167CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83356388
168MAF_26560356_Chip-Seq_TH2_Human0.82950689
169KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81273079
170NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79231566
171CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77807804
172PRDM14_20953172_ChIP-Seq_ESCs_Human0.75954510
173CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.75787446
174FLI1_21867929_ChIP-Seq_TH2_Mouse0.72890012
175FOXO3_23340844_ChIP-Seq_DLD1_Human0.72726152
176ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.70556534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.46133201
2MP0000569_abnormal_digit_pigmentation4.20173113
3MP0003303_peritoneal_inflammation3.65592900
4MP0004381_abnormal_hair_follicle2.77884593
5MP0003880_abnormal_central_pattern2.68942273
6MP0004883_abnormal_blood_vessel2.61284533
7MP0001800_abnormal_humoral_immune2.58670575
8MP0001188_hyperpigmentation2.58492861
9MP0000685_abnormal_immune_system2.48746983
10MP0003172_abnormal_lysosome_physiology2.47135032
11MP0005409_darkened_coat_color2.42774579
12MP0002277_abnormal_respiratory_mucosa2.34425155
13MP0009785_altered_susceptibility_to2.32681274
14MP0001835_abnormal_antigen_presentation2.29817567
15MP0002420_abnormal_adaptive_immunity2.24866793
16MP0001819_abnormal_immune_cell2.22962781
17MP0000383_abnormal_hair_follicle2.22181746
18MP0005174_abnormal_tail_pigmentation2.09053522
19MP0002254_reproductive_system_inflammat2.07273141
20MP0002405_respiratory_system_inflammati2.03551963
21MP0005646_abnormal_pituitary_gland2.00206395
22MP0003300_gastrointestinal_ulcer1.94944238
23MP0005423_abnormal_somatic_nervous1.93033249
24MP0001533_abnormal_skeleton_physiology1.84327318
25MP0002396_abnormal_hematopoietic_system1.80806861
26MP0002102_abnormal_ear_morphology1.80394293
27MP0003763_abnormal_thymus_physiology1.77063198
28MP0001984_abnormal_olfaction1.74031089
29MP0001501_abnormal_sleep_pattern1.73359245
30MP0003183_abnormal_peptide_metabolism1.70672002
31MP0005164_abnormal_response_to1.70021918
32MP0008260_abnormal_autophagy1.67853532
33MP0000716_abnormal_immune_system1.67837894
34MP0002398_abnormal_bone_marrow1.67110099
35MP0009046_muscle_twitch1.64839406
36MP0006292_abnormal_olfactory_placode1.63342750
37MP0004782_abnormal_surfactant_physiolog1.62489661
38MP0003941_abnormal_skin_development1.62310856
39MP0001486_abnormal_startle_reflex1.61416587
40MP0003635_abnormal_synaptic_transmissio1.57368120
41MP0009745_abnormal_behavioral_response1.56748679
42MP0000015_abnormal_ear_pigmentation1.55169688
43MP0005310_abnormal_salivary_gland1.54746024
44MP0005551_abnormal_eye_electrophysiolog1.54029300
45MP0004147_increased_porphyrin_level1.51859488
46MP0010678_abnormal_skin_adnexa1.51690137
47MP0004859_abnormal_synaptic_plasticity1.51336608
48MP0002090_abnormal_vision1.51207491
49MP0003221_abnormal_cardiomyocyte_apopto1.46881882
50MP0001845_abnormal_inflammatory_respons1.42323758
51MP0002166_altered_tumor_susceptibility1.39386916
52MP0003136_yellow_coat_color1.39167262
53MP0002009_preneoplasia1.39023007
54MP0010386_abnormal_urinary_bladder1.38408493
55MP0000465_gastrointestinal_hemorrhage1.37640177
56MP0005397_hematopoietic_system_phenotyp1.37306462
57MP0001545_abnormal_hematopoietic_system1.37306462
58MP0002722_abnormal_immune_system1.37264279
59MP0005645_abnormal_hypothalamus_physiol1.36623105
60MP0002572_abnormal_emotion/affect_behav1.36496176
61MP0002148_abnormal_hypersensitivity_rea1.36388371
62MP0000647_abnormal_sebaceous_gland1.36219358
63MP0003690_abnormal_glial_cell1.35941228
64MP0009379_abnormal_foot_pigmentation1.35198645
65MP0002132_abnormal_respiratory_system1.35034427
66MP0005379_endocrine/exocrine_gland_phen1.34880883
67MP0000689_abnormal_spleen_morphology1.33958463
68MP0003787_abnormal_imprinting1.33427377
69MP0005075_abnormal_melanosome_morpholog1.31812522
70MP0003866_abnormal_defecation1.31060771
71MP0005464_abnormal_platelet_physiology1.29793252
72MP0009764_decreased_sensitivity_to1.29019672
73MP0000703_abnormal_thymus_morphology1.28645854
74MP0004510_myositis1.28299103
75MP0002557_abnormal_social/conspecific_i1.26845497
76MP0002064_seizures1.25430449
77MP0004130_abnormal_muscle_cell1.23864500
78MP0002419_abnormal_innate_immunity1.23842936
79MP0002063_abnormal_learning/memory/cond1.22982796
80MP0010155_abnormal_intestine_physiology1.22094906
81MP0002095_abnormal_skin_pigmentation1.21108350
82MP0002429_abnormal_blood_cell1.19712798
83MP0001968_abnormal_touch/_nociception1.18966090
84MP0001502_abnormal_circadian_rhythm1.18622800
85MP0002067_abnormal_sensory_capabilities1.18370466
86MP0005387_immune_system_phenotype1.17453092
87MP0001790_abnormal_immune_system1.17453092
88MP0000538_abnormal_urinary_bladder1.16052722
89MP0002876_abnormal_thyroid_physiology1.15819680
90MP0002998_abnormal_bone_remodeling1.14160950
91MP0004947_skin_inflammation1.12814409
92MP0002796_impaired_skin_barrier1.12674023
93MP0002638_abnormal_pupillary_reflex1.12116393
94MP0001346_abnormal_lacrimal_gland1.11716827
95MP0008469_abnormal_protein_level1.10594735
96MP0004484_altered_response_of1.10383119
97MP0000858_altered_metastatic_potential1.08984079
98MP0000778_abnormal_nervous_system1.08806121
99MP0006276_abnormal_autonomic_nervous1.06382531
100MP0003656_abnormal_erythrocyte_physiolo1.05504666
101MP0004742_abnormal_vestibular_system1.05068791
102MP0003828_pulmonary_edema1.03741899
103MP0005671_abnormal_response_to1.02474271
104MP0002272_abnormal_nervous_system1.01847753
105MP0002735_abnormal_chemical_nociception1.01120017
106MP0001440_abnormal_grooming_behavior1.00634455
107MP0001986_abnormal_taste_sensitivity1.00300168
108MP0002909_abnormal_adrenal_gland0.98963866
109MP0002133_abnormal_respiratory_system0.98021729
110MP0005388_respiratory_system_phenotype0.98021729
111MP0002184_abnormal_innervation0.97728989
112MP0001324_abnormal_eye_pigmentation0.93976177
113MP0008995_early_reproductive_senescence0.92850863
114MP0005410_abnormal_fertilization0.92425633
115MP0003191_abnormal_cellular_cholesterol0.91925574
116MP0002452_abnormal_antigen_presenting0.91125991
117MP0002734_abnormal_mechanical_nocicepti0.90579557
118MP0002098_abnormal_vibrissa_morphology0.90557165
119MP0005000_abnormal_immune_tolerance0.90281704
120MP0003075_altered_response_to0.89688919
121MP0006082_CNS_inflammation0.88117179
122MP0002736_abnormal_nociception_after0.87988633
123MP0005451_abnormal_body_composition0.86446870
124MP0004084_abnormal_cardiac_muscle0.86154884
125MP0002332_abnormal_exercise_endurance0.85420500
126MP0000427_abnormal_hair_cycle0.85226244
127MP0001905_abnormal_dopamine_level0.84314952
128MP0009278_abnormal_bone_marrow0.84225548
129MP0002006_tumorigenesis0.83830252
130MP0003436_decreased_susceptibility_to0.82643818
131MP0002177_abnormal_outer_ear0.81829711
132MP0001853_heart_inflammation0.81377933
133MP0004808_abnormal_hematopoietic_stem0.80296349
134MP0005253_abnormal_eye_physiology0.79873745
135MP0000249_abnormal_blood_vessel0.78886927
136MP0000681_abnormal_thyroid_gland0.78831804
137MP0003045_fibrosis0.78364977
138MP0008004_abnormal_stomach_pH0.78088044
139MP0006072_abnormal_retinal_apoptosis0.77203237
140MP0001177_atelectasis0.76536458
141MP0005025_abnormal_response_to0.76379871
142MP0000604_amyloidosis0.75731401
143MP0002163_abnormal_gland_morphology0.75659757
144MP0001958_emphysema0.75576927
145MP0005166_decreased_susceptibility_to0.75328387
146MP0002723_abnormal_immune_serum0.73815458
147MP0001970_abnormal_pain_threshold0.72886594
148MP0003091_abnormal_cell_migration0.72760528
149MP0004019_abnormal_vitamin_homeostasis0.71766485
150MP0001851_eye_inflammation0.71745876
151MP0005647_abnormal_sex_gland0.71714244
152MP0010630_abnormal_cardiac_muscle0.69802602
153MP0005376_homeostasis/metabolism_phenot0.67489888
154MP0006054_spinal_hemorrhage0.66389775
155MP0009763_increased_sensitivity_to0.65281081
156MP0001663_abnormal_digestive_system0.65045618
157MP0003448_altered_tumor_morphology0.63160587
158MP0005390_skeleton_phenotype0.58746093
159MP0002928_abnormal_bile_duct0.57745582
160MP0001849_ear_inflammation0.53180569
161MP0009765_abnormal_xenobiotic_induced0.52899867
162MP0002933_joint_inflammation0.52439089
163MP0005076_abnormal_cell_differentiation0.51195594
164MP0000749_muscle_degeneration0.50352840
165MP0000371_diluted_coat_color0.49590469

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)4.33870977
2Stomatitis (HP:0010280)4.20642595
3Abnormality of secondary sexual hair (HP:0009888)4.07717299
4Abnormality of the axillary hair (HP:0100134)4.07717299
5Absent/shortened dynein arms (HP:0200106)3.91229633
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.91229633
7Gastrointestinal infarctions (HP:0005244)3.91190596
8Recurrent fungal infections (HP:0002841)3.88278137
9Spontaneous hematomas (HP:0007420)3.86876064
10Elevated erythrocyte sedimentation rate (HP:0003565)3.69810140
11Recurrent skin infections (HP:0001581)3.69163673
12Thick nail (HP:0001805)3.64569313
13Keratoconjunctivitis sicca (HP:0001097)3.63971519
14Recurrent abscess formation (HP:0002722)3.61661070
15Recurrent cutaneous fungal infections (HP:0011370)3.40532112
16Chronic mucocutaneous candidiasis (HP:0002728)3.40532112
17T lymphocytopenia (HP:0005403)3.34211721
18Keratoconjunctivitis (HP:0001096)3.31162292
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.30053062
20Encephalitis (HP:0002383)3.27452289
21Abnormality of T cell number (HP:0011839)3.13924508
22Hypochromic microcytic anemia (HP:0004840)3.11554571
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.11440753
24Focal motor seizures (HP:0011153)3.09464674
25Gingival bleeding (HP:0000225)3.08361124
26Chest pain (HP:0100749)3.02011516
27Peritonitis (HP:0002586)3.01073807
28Fair hair (HP:0002286)3.00789257
29Febrile seizures (HP:0002373)2.99366915
30Pulmonary embolism (HP:0002204)2.99363788
31Submucous cleft hard palate (HP:0000176)2.98051436
32Prolonged bleeding time (HP:0003010)2.96509656
33Papilledema (HP:0001085)2.94743533
34Optic neuritis (HP:0100653)2.91702841
35Retrobulbar optic neuritis (HP:0100654)2.91702841
36Generalized hypopigmentation of hair (HP:0011358)2.91060694
37Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.90266541
38Recurrent bacterial skin infections (HP:0005406)2.86345250
39Testicular atrophy (HP:0000029)2.84537860
40Cellulitis (HP:0100658)2.84277307
41Vasculitis (HP:0002633)2.83029904
42Prostate neoplasm (HP:0100787)2.82620697
43Arterial thrombosis (HP:0004420)2.82573645
44Eczematoid dermatitis (HP:0000976)2.82445531
45Obstructive lung disease (HP:0006536)2.82354017
46Chronic obstructive pulmonary disease (HP:0006510)2.82354017
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.78438066
48Leukocytosis (HP:0001974)2.73848874
49Urticaria (HP:0001025)2.71286835
50Hemiplegia (HP:0002301)2.69623490
51Subacute progressive viral hepatitis (HP:0006572)2.67113486
52Increased IgE level (HP:0003212)2.62776371
53Neonatal hypoglycemia (HP:0001998)2.62442885
54Fragile nails (HP:0001808)2.59769107
55Anhidrosis (HP:0000970)2.56748734
56Increased cerebral lipofuscin (HP:0011813)2.54984249
57Pulmonary infiltrates (HP:0002113)2.54400362
58Nephritis (HP:0000123)2.50557746
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47973456
60Amyloidosis (HP:0011034)2.47686041
61Episodic fever (HP:0001954)2.47376968
62Lip pit (HP:0100267)2.45588515
63Plantar hyperkeratosis (HP:0007556)2.45544839
64Epistaxis (HP:0000421)2.42311885
65Chronic otitis media (HP:0000389)2.42084864
66Orchitis (HP:0100796)2.40826077
67Microcytic anemia (HP:0001935)2.40185122
68Congenital, generalized hypertrichosis (HP:0004540)2.39983063
69Hypochromic anemia (HP:0001931)2.39706124
70Asymmetric septal hypertrophy (HP:0001670)2.39480953
71Abnormal ciliary motility (HP:0012262)2.35061588
72Abnormal respiratory motile cilium morphology (HP:0005938)2.33530031
73Abnormal respiratory epithelium morphology (HP:0012253)2.33530031
74Difficulty running (HP:0009046)2.30962219
75Milia (HP:0001056)2.30284689
76Progressive visual loss (HP:0000529)2.30129794
77Gingivitis (HP:0000230)2.30059058
78Stomach cancer (HP:0012126)2.29888534
79Recurrent viral infections (HP:0004429)2.28785514
80Abnormal respiratory motile cilium physiology (HP:0012261)2.27535891
81Cerebral palsy (HP:0100021)2.24980666
82Retinal atrophy (HP:0001105)2.23217165
83Periodontitis (HP:0000704)2.23068581
84Agitation (HP:0000713)2.21970757
85Abnormality of T cells (HP:0002843)2.20327040
86Absent eyebrow (HP:0002223)2.19943455
87Viral hepatitis (HP:0006562)2.19859239
88Broad-based gait (HP:0002136)2.17625804
89Exotropia (HP:0000577)2.15155434
90Abnormality of the endocardium (HP:0004306)2.15084166
91Protruding tongue (HP:0010808)2.14407135
92Premature loss of primary teeth (HP:0006323)2.14015372
93Anorexia (HP:0002039)2.13033508
94Gastrointestinal inflammation (HP:0004386)2.12939942
95Macular degeneration (HP:0000608)2.11770981
96Distal lower limb muscle weakness (HP:0009053)2.11609326
97Hypoplastic nipples (HP:0002557)2.11250466
98Congenital stationary night blindness (HP:0007642)2.10461683
99Decreased central vision (HP:0007663)2.07721867
100Osteomyelitis (HP:0002754)2.06129392
101Recurrent sinusitis (HP:0011108)2.06081239
102Inflammation of the large intestine (HP:0002037)2.05931305
103Gangrene (HP:0100758)2.05372740
104Epileptic encephalopathy (HP:0200134)2.04694378
105Abnormality of the pleura (HP:0002103)2.04204222
106Spondylolisthesis (HP:0003302)2.03089369
107Abolished electroretinogram (ERG) (HP:0000550)2.02484316
108Ectropion (HP:0000656)2.02243410
109Granulocytopenia (HP:0001913)2.02133920
110Inappropriate behavior (HP:0000719)2.00474184
111Abnormality of the peritoneum (HP:0002585)2.00252867
112Meningitis (HP:0001287)1.98977338
113Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96092691
114Focal seizures (HP:0007359)1.94784561
115Disinhibition (HP:0000734)1.94638661
116Abnormality of glycolipid metabolism (HP:0010969)1.94190627
117Abnormality of liposaccharide metabolism (HP:0010968)1.94190627
118Abnormality of glycosphingolipid metabolism (HP:0004343)1.94190627
119Alopecia of scalp (HP:0002293)1.93504815
120Vertigo (HP:0002321)1.93399157
121Thrombophlebitis (HP:0004418)1.93080705
122Glomerulonephritis (HP:0000099)1.92297100
123Chronic hepatic failure (HP:0100626)1.92204616
124Sepsis (HP:0100806)1.91794529
125Recurrent gram-negative bacterial infections (HP:0005420)1.88791656
126Amyotrophic lateral sclerosis (HP:0007354)1.88730072
127Muscle fiber splitting (HP:0003555)1.88283817
128Aplasia cutis congenita (HP:0001057)1.88196078
129Neoplasm of the tracheobronchial system (HP:0100552)1.87342292
130Eosinophilia (HP:0001880)1.87069692
131Abnormal glucose tolerance (HP:0001952)1.86710630
132Vitreoretinal degeneration (HP:0000655)1.86024767
133Hypohidrosis (HP:0000966)1.85607376
134Panhypogammaglobulinemia (HP:0003139)1.85280825
135Xerostomia (HP:0000217)1.85271705
136Cheilitis (HP:0100825)1.85126400
137Inability to walk (HP:0002540)1.84479295
138Hemoptysis (HP:0002105)1.83331411
139Aplasia involving bones of the upper limbs (HP:0009823)1.83085703
140Aplasia of the phalanges of the hand (HP:0009802)1.83085703
141Aplasia involving bones of the extremities (HP:0009825)1.83085703
142Increased IgM level (HP:0003496)1.82399436
143Mediastinal lymphadenopathy (HP:0100721)1.81582433
144Palpebral edema (HP:0100540)1.80535344
145Abnormal rod and cone electroretinograms (HP:0008323)1.80405152
146Abnormality of macular pigmentation (HP:0008002)1.79829489
147Dyschromatopsia (HP:0007641)1.79735988
148Corneal erosion (HP:0200020)1.79687468
149Palmoplantar hyperkeratosis (HP:0000972)1.77405431
150Palmar hyperkeratosis (HP:0010765)1.77321279
151Abnormality of the fingertips (HP:0001211)1.77305909
152Hip dysplasia (HP:0001385)1.76889542
153Hematochezia (HP:0002573)1.76472997
154Azoospermia (HP:0000027)1.75646908
155Systemic lupus erythematosus (HP:0002725)1.75530204
156Pustule (HP:0200039)1.74769059
157Slow saccadic eye movements (HP:0000514)1.74720209
158Papillary thyroid carcinoma (HP:0002895)1.74207259
159Absent hand (HP:0004050)1.73084160
160Abnormality of salivation (HP:0100755)1.71834497
161Onycholysis (HP:0001806)1.70837400
162Progressive cerebellar ataxia (HP:0002073)1.70019102
163Abnormality of the neuromuscular junction (HP:0003398)1.69923996
164Fatigable weakness (HP:0003473)1.69923996
165Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69520947
166Metaphyseal cupping (HP:0003021)1.69229904
167Myositis (HP:0100614)1.68962053
168White forelock (HP:0002211)1.68156097
169Abnormality of eosinophils (HP:0001879)1.68130241
170Attenuation of retinal blood vessels (HP:0007843)1.67717265
171Conical tooth (HP:0000698)1.67375227
172Bony spicule pigmentary retinopathy (HP:0007737)1.67048814
173Keratitis (HP:0000491)1.66037109
174Abnormal platelet volume (HP:0011876)1.65119101
175Frequent falls (HP:0002359)1.63731285
176Lymphopenia (HP:0001888)1.61707905
177Alveolar cell carcinoma (HP:0006519)1.60813270
178Acne (HP:0001061)1.60217517
179Glomerulopathy (HP:0100820)1.58662960
180Colitis (HP:0002583)1.55688789
181Dysostosis multiplex (HP:0000943)1.55124793
182Recurrent bronchitis (HP:0002837)1.54598530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.01264308
2AKT32.90780418
3RIPK42.73992139
4MAP2K32.72144688
5INSRR2.66680112
6MAP4K12.57878570
7PDK22.54202798
8CSK2.50177408
9TNIK2.09277721
10EPHA42.06089930
11NTRK32.03904071
12ZAK2.03627834
13SIK22.00073650
14IRAK41.98674525
15GRK11.96528080
16MARK11.87862007
17NEK61.82462731
18ZAP701.81532794
19STK161.68321177
20IRAK31.66856539
21GRK61.64076695
22SIK31.63067792
23MAPK131.63057588
24CDK31.61960893
25TNK21.59786709
26YES11.56749926
27MAP3K61.52562738
28TAOK31.51443833
29MAP3K141.51318914
30PINK11.50515831
31GRK71.48686774
32FGFR31.47920609
33TAOK11.47784041
34MAPK151.46249962
35EPHB11.45731932
36JAK21.41944237
37JAK31.40124474
38BMPR21.38748842
39MAP3K121.33672668
40MAPK71.28645189
41MAP2K61.27681696
42KSR21.27115610
43FES1.26474479
44MAP3K71.20198587
45MAPK121.19869167
46TEC1.17967485
47MAP3K131.17467340
48ERBB31.16021119
49PKN11.13734504
50SGK21.09094403
51IRAK21.08919588
52NEK11.08276187
53PTK2B1.06110902
54CSF1R1.05128820
55FRK1.04646118
56NTRK21.04396364
57ADRBK21.03894613
58NUAK11.03860324
59ITK1.03381040
60TGFBR21.03234255
61MAP2K71.03141693
62MAP3K20.98323781
63LCK0.96662753
64MAPKAPK50.94755463
65MUSK0.94077300
66KSR10.92967649
67IKBKB0.91468573
68MAP3K10.90810009
69BLK0.90018514
70STK110.89237402
71IRAK10.89061243
72TYK20.88997841
73TXK0.87170296
74WNK10.85333330
75HCK0.85056139
76MARK30.84222778
77NLK0.84026994
78PRKCE0.81545808
79MATK0.80484441
80SYK0.80338420
81HIPK20.79277972
82RET0.77283790
83ERN10.77137323
84MAP3K50.76252311
85PTK60.75517371
86DYRK1B0.74571929
87TBK10.71682725
88EPHB20.71030642
89RAF10.70247437
90PRPF4B0.69741291
91FGR0.66631965
92EIF2AK20.66591741
93PIK3CG0.65445034
94ERBB20.63732004
95DAPK20.61801481
96CLK10.61278031
97CAMK2A0.61082125
98BRD40.60639011
99BMPR1B0.60207383
100IKBKE0.59537484
101KIT0.59330603
102SGK4940.59240977
103SGK2230.59240977
104FYN0.58941702
105PHKG10.58901873
106PHKG20.58901873
107FGFR20.58603434
108CAMK1D0.58109047
109PDPK10.58057258
110MAP3K110.57867112
111CAMK40.56630004
112CCNB10.56447574
113LYN0.55875896
114MARK20.55361873
115SGK10.54797841
116PRKD10.53997709
117BTK0.52366103
118PDK10.52175226
119SGK30.51608492
120RPS6KA20.51330264
121TRPM70.50648357
122CAMK1G0.50450511
123EPHA30.50180004
124CAMK10.48765981
125PRKCQ0.47763154
126LRRK20.47657302
127CAMKK20.47394586
128ACVR1B0.47173586
129DYRK1A0.46165809
130NEK90.45841978
131PRKD20.44778285
132STK240.44678621
133FER0.44466181
134DYRK30.44311597
135PKN20.44212855
136MKNK20.43935308
137MAP2K40.42994324
138MST1R0.42879539
139CDK50.42306193
140STK380.40486826
141MAP3K30.40007194
142CDK60.39876695
143STK100.38901483
144PRKG10.38528475
145PRKAA20.38125455
146JAK10.38032354
147GRK50.37939509

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.41139793
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.20322785
3Phototransduction_Homo sapiens_hsa047442.07160825
4Morphine addiction_Homo sapiens_hsa050321.84240273
5Olfactory transduction_Homo sapiens_hsa047401.77726904
6T cell receptor signaling pathway_Homo sapiens_hsa046601.70642664
7Glutamatergic synapse_Homo sapiens_hsa047241.69799392
8Taste transduction_Homo sapiens_hsa047421.63922430
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57474561
10Acute myeloid leukemia_Homo sapiens_hsa052211.56221529
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54103271
12Serotonergic synapse_Homo sapiens_hsa047261.53715642
13Malaria_Homo sapiens_hsa051441.46658650
14Non-small cell lung cancer_Homo sapiens_hsa052231.46194539
15Sphingolipid metabolism_Homo sapiens_hsa006001.45687808
16ABC transporters_Homo sapiens_hsa020101.45225027
17Circadian entrainment_Homo sapiens_hsa047131.42236071
18Legionellosis_Homo sapiens_hsa051341.40497118
19Graft-versus-host disease_Homo sapiens_hsa053321.38752240
20Staphylococcus aureus infection_Homo sapiens_hsa051501.38144325
21GABAergic synapse_Homo sapiens_hsa047271.34435013
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32958232
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.32670872
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32054045
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31134170
26Allograft rejection_Homo sapiens_hsa053301.30595664
27Calcium signaling pathway_Homo sapiens_hsa040201.28542676
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27943428
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27492924
30Renin secretion_Homo sapiens_hsa049241.27119312
31VEGF signaling pathway_Homo sapiens_hsa043701.25152331
32Salivary secretion_Homo sapiens_hsa049701.24887824
33Osteoclast differentiation_Homo sapiens_hsa043801.24439914
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23687305
35Influenza A_Homo sapiens_hsa051641.23344761
36Cocaine addiction_Homo sapiens_hsa050301.23002345
37Amphetamine addiction_Homo sapiens_hsa050311.22145205
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21319515
39Renal cell carcinoma_Homo sapiens_hsa052111.20025202
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.19047315
41Autoimmune thyroid disease_Homo sapiens_hsa053201.19004372
42Pancreatic cancer_Homo sapiens_hsa052121.18220071
43Rheumatoid arthritis_Homo sapiens_hsa053231.17602695
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15700549
45Cholinergic synapse_Homo sapiens_hsa047251.15673931
46Other glycan degradation_Homo sapiens_hsa005111.15054557
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.14405034
48FoxO signaling pathway_Homo sapiens_hsa040681.11803361
49Chronic myeloid leukemia_Homo sapiens_hsa052201.11746739
50Primary immunodeficiency_Homo sapiens_hsa053401.08775192
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08535869
52Chemokine signaling pathway_Homo sapiens_hsa040621.07125978
53B cell receptor signaling pathway_Homo sapiens_hsa046621.07047211
54Prolactin signaling pathway_Homo sapiens_hsa049171.04483297
55Lysosome_Homo sapiens_hsa041421.03949804
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03895319
57Hepatitis B_Homo sapiens_hsa051611.03319638
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02079831
59Insulin secretion_Homo sapiens_hsa049111.00471719
60Synaptic vesicle cycle_Homo sapiens_hsa047211.00408707
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00322913
62Axon guidance_Homo sapiens_hsa043601.00261370
63Endometrial cancer_Homo sapiens_hsa052130.99592971
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98531209
65Collecting duct acid secretion_Homo sapiens_hsa049660.98276436
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98028838
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98028225
68cAMP signaling pathway_Homo sapiens_hsa040240.97638026
69Long-term potentiation_Homo sapiens_hsa047200.97048993
70Circadian rhythm_Homo sapiens_hsa047100.94119735
71Type II diabetes mellitus_Homo sapiens_hsa049300.93554723
72Viral myocarditis_Homo sapiens_hsa054160.93440225
73Dopaminergic synapse_Homo sapiens_hsa047280.93236833
74Inositol phosphate metabolism_Homo sapiens_hsa005620.92689017
75Regulation of autophagy_Homo sapiens_hsa041400.91541208
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91050022
77mTOR signaling pathway_Homo sapiens_hsa041500.90569233
78Gastric acid secretion_Homo sapiens_hsa049710.90320045
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88561731
80Oxytocin signaling pathway_Homo sapiens_hsa049210.88463854
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87367156
82GnRH signaling pathway_Homo sapiens_hsa049120.86321221
83Ether lipid metabolism_Homo sapiens_hsa005650.86166790
84Colorectal cancer_Homo sapiens_hsa052100.85943267
85Type I diabetes mellitus_Homo sapiens_hsa049400.85656895
86Long-term depression_Homo sapiens_hsa047300.85468220
87Pancreatic secretion_Homo sapiens_hsa049720.84637521
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.84524517
89Phagosome_Homo sapiens_hsa041450.84372746
90Leishmaniasis_Homo sapiens_hsa051400.82449474
91Antigen processing and presentation_Homo sapiens_hsa046120.81216073
92Herpes simplex infection_Homo sapiens_hsa051680.80343493
93African trypanosomiasis_Homo sapiens_hsa051430.79524432
94Choline metabolism in cancer_Homo sapiens_hsa052310.79422904
95Pertussis_Homo sapiens_hsa051330.78938064
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.78365412
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77179894
98Insulin resistance_Homo sapiens_hsa049310.75407614
99Tuberculosis_Homo sapiens_hsa051520.75213752
100ErbB signaling pathway_Homo sapiens_hsa040120.74185596
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72758981
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.71881805
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.70465150
104Dorso-ventral axis formation_Homo sapiens_hsa043200.70267103
105Salmonella infection_Homo sapiens_hsa051320.68934265
106Arachidonic acid metabolism_Homo sapiens_hsa005900.68839549
107Notch signaling pathway_Homo sapiens_hsa043300.67689379
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.67561350
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.67302732
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67264924
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67099919
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66603762
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66603376
114HIF-1 signaling pathway_Homo sapiens_hsa040660.66000408
115Prostate cancer_Homo sapiens_hsa052150.65273456
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.64599800
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.64370899
118MAPK signaling pathway_Homo sapiens_hsa040100.61516226
119Platelet activation_Homo sapiens_hsa046110.59820203
120Hematopoietic cell lineage_Homo sapiens_hsa046400.59514501
121Apoptosis_Homo sapiens_hsa042100.58944871
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58721308
123TNF signaling pathway_Homo sapiens_hsa046680.58714563
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58243476
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58076653
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58042710
127Estrogen signaling pathway_Homo sapiens_hsa049150.57928939
128Glioma_Homo sapiens_hsa052140.57899162
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57726686
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56000322
131Asthma_Homo sapiens_hsa053100.55889344
132Rap1 signaling pathway_Homo sapiens_hsa040150.55615671
133Vitamin B6 metabolism_Homo sapiens_hsa007500.55042709
134Toxoplasmosis_Homo sapiens_hsa051450.53479082
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53390862
136Ras signaling pathway_Homo sapiens_hsa040140.53292216
137Ovarian steroidogenesis_Homo sapiens_hsa049130.53175385
138Endocytosis_Homo sapiens_hsa041440.52634987
139Linoleic acid metabolism_Homo sapiens_hsa005910.51661604
140Amoebiasis_Homo sapiens_hsa051460.51297947
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49289754
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49227536
143Vitamin digestion and absorption_Homo sapiens_hsa049770.48257214
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48131632
145Dilated cardiomyopathy_Homo sapiens_hsa054140.48102232
146Insulin signaling pathway_Homo sapiens_hsa049100.46962804
147Measles_Homo sapiens_hsa051620.46884957
148Hepatitis C_Homo sapiens_hsa051600.46705254

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