AGPAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein retention in ER lumen (GO:0006621)4.78678950
2synaptic vesicle maturation (GO:0016188)4.61716771
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.41715201
4locomotory exploration behavior (GO:0035641)3.96306504
5protein maturation by protein folding (GO:0022417)3.95633838
6proline biosynthetic process (GO:0006561)3.90817147
7planar cell polarity pathway involved in neural tube closure (GO:0090179)3.89171971
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.84087245
9vocalization behavior (GO:0071625)3.71565542
10COPI coating of Golgi vesicle (GO:0048205)3.67889796
11Golgi transport vesicle coating (GO:0048200)3.67889796
12sodium ion export (GO:0071436)3.64045198
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.60803827
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.60376496
15layer formation in cerebral cortex (GO:0021819)3.60368371
16acrosome assembly (GO:0001675)3.55800138
17regulation of early endosome to late endosome transport (GO:2000641)3.51964156
18cell communication by electrical coupling (GO:0010644)3.51045817
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.49122991
20regulation of synapse structural plasticity (GO:0051823)3.45035633
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.43124370
22heterochromatin organization (GO:0070828)3.42927371
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.41627983
24cytoskeletal anchoring at plasma membrane (GO:0007016)3.39572457
25regulation of mammary gland epithelial cell proliferation (GO:0033599)3.31789687
26protein carboxylation (GO:0018214)3.28125575
27peptidyl-glutamic acid carboxylation (GO:0017187)3.28125575
28acrosome reaction (GO:0007340)3.24809004
29basement membrane organization (GO:0071711)3.24377927
30synaptic vesicle exocytosis (GO:0016079)3.21318133
31dendritic spine morphogenesis (GO:0060997)3.19798708
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.16843130
33proline metabolic process (GO:0006560)3.10486743
34sperm motility (GO:0030317)3.10404339
35G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.09326834
36activation of protein kinase A activity (GO:0034199)3.06070396
37negative regulation of organelle assembly (GO:1902116)3.04561445
38proline transport (GO:0015824)3.04323821
39regulation of glutamate receptor signaling pathway (GO:1900449)3.02859826
40glucose 6-phosphate metabolic process (GO:0051156)3.01991203
41convergent extension (GO:0060026)3.00308369
42protein localization to synapse (GO:0035418)2.98921849
43cellular response to prostaglandin stimulus (GO:0071379)2.96718505
44exploration behavior (GO:0035640)2.95424873
45regulation of ARF protein signal transduction (GO:0032012)2.94810125
46adherens junction assembly (GO:0034333)2.93857748
47barbed-end actin filament capping (GO:0051016)2.88806524
48synaptic vesicle docking involved in exocytosis (GO:0016081)2.85849209
49blood coagulation, intrinsic pathway (GO:0007597)2.84876525
50cochlea morphogenesis (GO:0090103)2.84487471
51cerebellar Purkinje cell layer development (GO:0021680)2.84215473
52protein-DNA complex disassembly (GO:0032986)2.83948198
53nucleosome disassembly (GO:0006337)2.83948198
54regulation of synaptic vesicle exocytosis (GO:2000300)2.83357784
55cellular potassium ion homeostasis (GO:0030007)2.83252003
56negative regulation of catenin import into nucleus (GO:0035414)2.81653429
57platelet degranulation (GO:0002576)2.80637937
58neuronal action potential propagation (GO:0019227)2.78841034
59regulation of long-term neuronal synaptic plasticity (GO:0048169)2.78299483
60regulation of neuronal synaptic plasticity (GO:0048168)2.77697835
61peptidyl-proline hydroxylation (GO:0019511)2.77473942
62left/right pattern formation (GO:0060972)2.75933839
63dendritic spine organization (GO:0097061)2.74298808
64cerebellar granule cell differentiation (GO:0021707)2.73530207
65negative regulation of potassium ion transmembrane transport (GO:1901380)2.70322190
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69851287
67calcium ion-dependent exocytosis (GO:0017156)2.69803879
68regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.69646930
69platelet aggregation (GO:0070527)2.69310716
70neuromuscular process controlling balance (GO:0050885)2.69255822
71ionotropic glutamate receptor signaling pathway (GO:0035235)2.69097087
72glutamate secretion (GO:0014047)2.68650122
73neuronal ion channel clustering (GO:0045161)2.68537799
74NADH metabolic process (GO:0006734)2.68359566
75receptor recycling (GO:0001881)2.66879065
76negative regulation of cell size (GO:0045792)2.66348201
77plasma membrane repair (GO:0001778)2.65340753
78negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.65159077
79cell junction maintenance (GO:0034331)2.64506720
80fusion of sperm to egg plasma membrane (GO:0007342)2.64228565
81triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.62915555
82neuron cell-cell adhesion (GO:0007158)2.62714478
83cell-substrate adherens junction assembly (GO:0007045)2.61728774
84focal adhesion assembly (GO:0048041)2.61728774
85regulation of cholesterol esterification (GO:0010872)2.60971500
86regulation of ARF GTPase activity (GO:0032312)2.60905067
87positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.60160351
88paraxial mesoderm development (GO:0048339)2.57808841
89regulation of synaptic vesicle transport (GO:1902803)2.56186320
90extracellular fibril organization (GO:0043206)2.54584833
91adenosine receptor signaling pathway (GO:0001973)2.54471453
92negative regulation of microtubule polymerization (GO:0031115)2.53981648
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53792937
94membrane depolarization during action potential (GO:0086010)2.52863609
95positive regulation of Rho protein signal transduction (GO:0035025)2.51437760
96regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.50947897
97neuron recognition (GO:0008038)2.50578344
98regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.48453503
99positive regulation of membrane potential (GO:0045838)2.47765806
100potassium ion import (GO:0010107)2.47533075
101stress fiber assembly (GO:0043149)2.47029262
102clathrin coat assembly (GO:0048268)2.46889575
103modulation by virus of host morphology or physiology (GO:0019048)2.46727020
104positive regulation of synapse maturation (GO:0090129)2.45743410
105signal complex assembly (GO:0007172)2.44615316
106protein insertion into membrane (GO:0051205)2.44125158
107pentose-phosphate shunt (GO:0006098)2.43789887
108response to parathyroid hormone (GO:0071107)2.43622652
109negative regulation of inclusion body assembly (GO:0090084)2.42930208
110negative regulation of erythrocyte differentiation (GO:0045647)2.42111091
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.41684342
1124-hydroxyproline metabolic process (GO:0019471)2.41482054
113protein localization to endosome (GO:0036010)2.40875784
114semaphorin-plexin signaling pathway (GO:0071526)2.40582168
115regulation of calcium ion transmembrane transport (GO:1903169)2.40430215
116regulation of calcium ion transmembrane transporter activity (GO:1901019)2.40430215
117positive regulation of synaptic transmission, GABAergic (GO:0032230)2.40257013
118protein-lipid complex assembly (GO:0065005)2.40164366
119peripheral nervous system axon ensheathment (GO:0032292)2.39804666
120myelination in peripheral nervous system (GO:0022011)2.39804666
121positive regulation of dendritic spine development (GO:0060999)2.39699850
122regulation of NFAT protein import into nucleus (GO:0051532)2.39057158
123epithelial cell-cell adhesion (GO:0090136)2.38665672
124Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.38332297
125alpha-linolenic acid metabolic process (GO:0036109)2.38268140
126regulation of excitatory postsynaptic membrane potential (GO:0060079)2.37662559
127postsynaptic membrane organization (GO:0001941)2.37418860
128cell-cell junction maintenance (GO:0045217)2.37100920
129cell communication involved in cardiac conduction (GO:0086065)2.36438511
130establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.35960760
131regulation of dendritic spine morphogenesis (GO:0061001)2.35754628
132plasma lipoprotein particle assembly (GO:0034377)2.34594695
133neurotransmitter secretion (GO:0007269)2.33786316
134regulation of extracellular matrix disassembly (GO:0010715)2.33493602
135nerve growth factor signaling pathway (GO:0038180)2.32966789
136negative regulation of homotypic cell-cell adhesion (GO:0034111)2.32755498
137camera-type eye morphogenesis (GO:0048593)2.32336384
138positive regulation of receptor recycling (GO:0001921)2.32197138
139glycine transport (GO:0015816)2.32103290
140regulation of autophagic vacuole assembly (GO:2000785)2.31413046
141gluconeogenesis (GO:0006094)2.31373054
142dopamine receptor signaling pathway (GO:0007212)2.30817769
143skin morphogenesis (GO:0043589)2.29629821
144cell migration in hindbrain (GO:0021535)2.29068651
145NADPH regeneration (GO:0006740)2.29024043
146activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.28911200
147monosaccharide biosynthetic process (GO:0046364)2.27739615
148cell-substrate junction assembly (GO:0007044)2.27707209
149cortical actin cytoskeleton organization (GO:0030866)2.26449092
150actin filament depolymerization (GO:0030042)2.26102048
151regulation of chromatin binding (GO:0035561)2.25683988
152cell wall macromolecule catabolic process (GO:0016998)2.25682826
153cell wall macromolecule metabolic process (GO:0044036)2.25682826
154potassium ion homeostasis (GO:0055075)2.24701220
155cellular response to nerve growth factor stimulus (GO:1990090)2.24070219
156response to nerve growth factor (GO:1990089)2.24070219
157plasma membrane fusion (GO:0045026)2.23946453
158protein targeting to plasma membrane (GO:0072661)2.23643468
159dendrite morphogenesis (GO:0048813)2.23249859
160positive regulation of fibroblast migration (GO:0010763)2.22373139
161long-term memory (GO:0007616)2.21902401
162maternal placenta development (GO:0001893)2.21790582
163positive regulation of nuclease activity (GO:0032075)2.20241574
164hexose biosynthetic process (GO:0019319)2.20120198
165microtubule severing (GO:0051013)2.19849879
166positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.19704412
167regulation of postsynaptic membrane potential (GO:0060078)2.19645310
168axonal fasciculation (GO:0007413)2.19385283
169glucose catabolic process (GO:0006007)2.18812935
170synaptic transmission, glutamatergic (GO:0035249)2.18666018
171vesicle coating (GO:0006901)2.18070642
172modulation by virus of host process (GO:0019054)2.17790380
173regulation of plasminogen activation (GO:0010755)2.16989543
174positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.16635791
175regulation of glucose import in response to insulin stimulus (GO:2001273)2.16592268
176negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.16491851
177glycolytic process (GO:0006096)2.16413161
178cellular response to epidermal growth factor stimulus (GO:0071364)2.16360573
179membrane depolarization (GO:0051899)2.16298099
180synaptic vesicle endocytosis (GO:0048488)2.16172834
181G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.16097224
182response to acidic pH (GO:0010447)2.15347976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.65254979
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.98015089
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.78274235
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.74456989
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.68915730
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.37071724
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.34633336
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34433710
9* ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.20583473
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13325659
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.12393352
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.03641034
13SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03256215
14* SRY_22984422_ChIP-ChIP_TESTIS_Rat2.02557773
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01096826
16DROSHA_22980978_ChIP-Seq_HELA_Human1.97412754
17LXR_22292898_ChIP-Seq_THP-1_Human1.96926091
18KDM2B_26808549_Chip-Seq_K562_Human1.95513084
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93753423
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92948491
21* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92948491
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92307944
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.91251038
24KDM2B_26808549_Chip-Seq_DND41_Human1.91019546
25REST_21632747_ChIP-Seq_MESCs_Mouse1.90910340
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90369444
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89723803
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81218991
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81031981
30CLOCK_20551151_ChIP-Seq_293T_Human1.76959766
31EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.74848058
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.73456175
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.72374770
34* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72291270
35* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71387346
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69836462
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68480326
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.63406314
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.62806654
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.61238591
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59903914
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57662810
43GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54259918
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52447822
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49590835
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49277632
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49249430
48* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48068059
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48015423
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46552692
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45801097
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45619250
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44346318
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.43891058
55TCF7_22412390_ChIP-Seq_EML_Mouse1.37681408
56CTCF_27219007_Chip-Seq_Bcells_Human1.37205044
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36903621
58* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36786237
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35995949
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.35039665
61ZNF274_21170338_ChIP-Seq_K562_Hela1.34545022
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34220034
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33481405
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30981648
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30786270
66* NCOR1_26117541_ChIP-Seq_K562_Human1.30433701
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30193118
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28763757
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.28388245
70SMC4_20622854_ChIP-Seq_HELA_Human1.27728196
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27102448
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26210721
73VDR_21846776_ChIP-Seq_THP-1_Human1.25541886
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23433421
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22981710
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20465136
77* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18686666
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18445999
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17180979
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15736794
81RARA_24833708_ChIP-Seq_LIVER_Mouse1.14331413
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14284305
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14207635
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14141598
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.13925687
86* CREB1_26743006_Chip-Seq_LNCaP_Human1.13497168
87OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13215239
88* ELK3_25401928_ChIP-Seq_HUVEC_Human1.13117524
89P68_20966046_ChIP-Seq_HELA_Human1.13096460
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12750545
91TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12665278
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12240760
93TET1_21490601_ChIP-Seq_MESCs_Mouse1.10962642
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.10428931
95GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.10140359
96* TET1_21451524_ChIP-Seq_MESCs_Mouse1.09831409
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09092525
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08649840
99RXR_22158963_ChIP-Seq_LIVER_Mouse1.08339541
100RACK7_27058665_Chip-Seq_MCF-7_Human1.08222898
101* NANOG_21062744_ChIP-ChIP_HESCs_Human1.08059255
102GATA1_26923725_Chip-Seq_HPCs_Mouse1.07651035
103MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07033128
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07006489
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06658472
106* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06382667
107TP53_22127205_ChIP-Seq_IMR90_Human1.05831242
108ZNF263_19887448_ChIP-Seq_K562_Human1.05339991
109STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.05193622
110OCT4_19829295_ChIP-Seq_ESCs_Human1.05131581
111SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05084226
112* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04954160
113OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04850781
114CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04765746
115MYC_22102868_ChIP-Seq_BL_Human1.03144630
116P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03077722
117* SA1_27219007_Chip-Seq_ERYTHROID_Human1.02930386
118MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02747605
119GATA1_19941827_ChIP-Seq_MEL_Mouse1.01718588
120EED_16625203_ChIP-ChIP_MESCs_Mouse1.01605832
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01257140
122* XRN2_22483619_ChIP-Seq_HELA_Human1.00221514
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00047064
124ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00028448
125TP53_23651856_ChIP-Seq_MEFs_Mouse0.97792509
126ATF3_27146783_Chip-Seq_COLON_Human0.97665177
127NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97172678
128TP63_22573176_ChIP-Seq_HFKS_Human0.96107201
129ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96092716
130SA1_27219007_Chip-Seq_Bcells_Human0.96083482
131JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95838552
132BCOR_27268052_Chip-Seq_Bcells_Human0.95745964
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95726251
134* SPI1_23127762_ChIP-Seq_K562_Human0.95649558
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95542597
136TP53_20018659_ChIP-ChIP_R1E_Mouse0.95213405
137GATA1_19941826_ChIP-Seq_K562_Human0.94776668
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94067522
139KLF4_19829295_ChIP-Seq_ESCs_Human0.93483053
140SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92262625
141* YY1_22570637_ChIP-Seq_MALME-3M_Human0.90704054
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88086495
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87942378
144BCL6_27268052_Chip-Seq_Bcells_Human0.87610040
145RUNX1_27514584_Chip-Seq_MCF-7_Human0.87149597
146ESR2_21235772_ChIP-Seq_MCF-7_Human0.87116921
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87057717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.81523130
2MP0003705_abnormal_hypodermis_morpholog3.96839214
3MP0005410_abnormal_fertilization3.61168676
4MP0008438_abnormal_cutaneous_collagen3.11633232
5MP0003635_abnormal_synaptic_transmissio2.80604898
6MP0010030_abnormal_orbit_morphology2.80172677
7MP0004270_analgesia2.72561776
8MP0003123_paternal_imprinting2.68116442
9MP0000751_myopathy2.65651969
10MP0003566_abnormal_cell_adhesion2.62765714
11MP0005464_abnormal_platelet_physiology2.56084921
12MP0004858_abnormal_nervous_system2.52977589
13MP0003880_abnormal_central_pattern2.51464858
14MP0005409_darkened_coat_color2.51062167
15MP0005257_abnormal_intraocular_pressure2.34225341
16MP0003646_muscle_fatigue2.26865335
17MP0004272_abnormal_basement_membrane2.22189004
18MP0003283_abnormal_digestive_organ2.19865807
19MP0001348_abnormal_lacrimal_gland2.15521497
20MP0002063_abnormal_learning/memory/cond2.08343365
21MP0005623_abnormal_meninges_morphology2.02781412
22MP0002249_abnormal_larynx_morphology2.02680526
23MP0009046_muscle_twitch2.01059411
24MP0002064_seizures2.00062280
25MP0002909_abnormal_adrenal_gland1.94706672
26MP0009745_abnormal_behavioral_response1.92985577
27MP0003329_amyloid_beta_deposits1.89216759
28MP0004145_abnormal_muscle_electrophysio1.89165143
29MP0000678_abnormal_parathyroid_gland1.87322256
30MP0009379_abnormal_foot_pigmentation1.85111634
31MP0002822_catalepsy1.77625497
32MP0002837_dystrophic_cardiac_calcinosis1.74421412
33MP0008569_lethality_at_weaning1.69301717
34MP0004233_abnormal_muscle_weight1.68669560
35MP0002572_abnormal_emotion/affect_behav1.66385175
36MP0003942_abnormal_urinary_system1.65148504
37MP0003879_abnormal_hair_cell1.62176110
38MP0004510_myositis1.61013018
39MP0008004_abnormal_stomach_pH1.60112298
40MP0004811_abnormal_neuron_physiology1.60076929
41MP0000778_abnormal_nervous_system1.59322873
42MP0001486_abnormal_startle_reflex1.55865945
43MP0000749_muscle_degeneration1.52737294
44MP0002734_abnormal_mechanical_nocicepti1.49566894
45MP0009780_abnormal_chondrocyte_physiolo1.49455904
46MP0005451_abnormal_body_composition1.49290411
47MP0002653_abnormal_ependyma_morphology1.49263379
48MP0002733_abnormal_thermal_nociception1.49154415
49MP0002272_abnormal_nervous_system1.48184225
50MP0000566_synostosis1.46343083
51MP0000955_abnormal_spinal_cord1.45934930
52MP0008260_abnormal_autophagy1.44985777
53MP0003303_peritoneal_inflammation1.44232079
54MP0008961_abnormal_basal_metabolism1.43992748
55MP0005423_abnormal_somatic_nervous1.42652541
56MP0009053_abnormal_anal_canal1.41707318
57MP0001968_abnormal_touch/_nociception1.40281799
58MP0003385_abnormal_body_wall1.38795872
59MP0009672_abnormal_birth_weight1.35068053
60MP0004130_abnormal_muscle_cell1.34933028
61MP0003698_abnormal_male_reproductive1.33494847
62MP0001970_abnormal_pain_threshold1.33466514
63MP0000747_muscle_weakness1.29085667
64MP0003878_abnormal_ear_physiology1.29014936
65MP0005377_hearing/vestibular/ear_phenot1.29014936
66MP0004087_abnormal_muscle_fiber1.27919051
67MP0009840_abnormal_foam_cell1.27195623
68MP0003172_abnormal_lysosome_physiology1.26553533
69MP0000759_abnormal_skeletal_muscle1.22868120
70MP0004885_abnormal_endolymph1.21048072
71MP0005360_urolithiasis1.20592628
72MP0001440_abnormal_grooming_behavior1.18716711
73MP0002106_abnormal_muscle_physiology1.17529057
74MP0002184_abnormal_innervation1.15100849
75MP0005083_abnormal_biliary_tract1.14143165
76MP0001730_embryonic_growth_arrest1.13244739
77MP0001299_abnormal_eye_distance/1.12399377
78MP0003137_abnormal_impulse_conducting1.10721471
79MP0002882_abnormal_neuron_morphology1.10210527
80MP0000750_abnormal_muscle_regeneration1.10107999
81MP0002067_abnormal_sensory_capabilities1.08093333
82MP0002066_abnormal_motor_capabilities/c1.08088496
83MP0003634_abnormal_glial_cell1.08084611
84MP0002269_muscular_atrophy1.06953530
85MP0002557_abnormal_social/conspecific_i1.06908104
86MP0008932_abnormal_embryonic_tissue1.06021076
87MP0003279_aneurysm1.03507035
88MP0002152_abnormal_brain_morphology1.03364419
89MP0000013_abnormal_adipose_tissue1.01628074
90MP0002877_abnormal_melanocyte_morpholog1.00087902
91MP0004036_abnormal_muscle_relaxation0.99479285
92MP0010368_abnormal_lymphatic_system0.98040168
93MP0002736_abnormal_nociception_after0.97423639
94MP0003045_fibrosis0.97328315
95MP0000920_abnormal_myelination0.97042498
96MP0005386_behavior/neurological_phenoty0.95805946
97MP0004924_abnormal_behavior0.95805946
98MP0004084_abnormal_cardiac_muscle0.95326538
99MP0000534_abnormal_ureter_morphology0.94186533
100MP0002089_abnormal_postnatal_growth/wei0.93776656
101MP0005171_absent_coat_pigmentation0.92824146
102MP0003122_maternal_imprinting0.92373553
103MP0002735_abnormal_chemical_nociception0.92072196
104MP0004215_abnormal_myocardial_fiber0.91968245
105MP0001765_abnormal_ion_homeostasis0.91534326
106MP0001958_emphysema0.89898048
107MP0005369_muscle_phenotype0.89880745
108MP0001915_intracranial_hemorrhage0.89691352
109MP0003633_abnormal_nervous_system0.89636885
110MP0002234_abnormal_pharynx_morphology0.89208279
111MP0009384_cardiac_valve_regurgitation0.89120236
112MP0003115_abnormal_respiratory_system0.87769549
113MP0005076_abnormal_cell_differentiation0.87191006
114MP0005330_cardiomyopathy0.86933317
115MP0005620_abnormal_muscle_contractility0.86011087
116MP0004085_abnormal_heartbeat0.84196500
117MP0004043_abnormal_pH_regulation0.83027447
118MP0001849_ear_inflammation0.82857150
119MP0005375_adipose_tissue_phenotype0.82280990
120MP0004185_abnormal_adipocyte_glucose0.82175818
121MP0002085_abnormal_embryonic_tissue0.80758003
122MP0005670_abnormal_white_adipose0.80392598
123MP0003136_yellow_coat_color0.80300698
124MP0002697_abnormal_eye_size0.78423595
125MP0002132_abnormal_respiratory_system0.78336327
126MP0006138_congestive_heart_failure0.78259346
127MP0003075_altered_response_to0.78256149
128MP0001929_abnormal_gametogenesis0.77270408
129MP0001501_abnormal_sleep_pattern0.77225279
130MP0000428_abnormal_craniofacial_morphol0.76084516
131MP0010630_abnormal_cardiac_muscle0.75969263
132MP0004484_altered_response_of0.75301963
133MP0010329_abnormal_lipoprotein_level0.74502806
134MP0002080_prenatal_lethality0.74260789
135MP0003938_abnormal_ear_development0.73412520
136MP0002972_abnormal_cardiac_muscle0.72860848
137MP0003861_abnormal_nervous_system0.72824326
138MP0005666_abnormal_adipose_tissue0.72195532
139MP0000049_abnormal_middle_ear0.72087578
140MP0003631_nervous_system_phenotype0.71620711
141MP0001664_abnormal_digestion0.71361528
142MP0000858_altered_metastatic_potential0.69889711
143MP0002116_abnormal_craniofacial_bone0.69716801
144MP0005499_abnormal_olfactory_system0.69345516
145MP0005394_taste/olfaction_phenotype0.69345516
146MP0005310_abnormal_salivary_gland0.69016513
147MP0002229_neurodegeneration0.68853275
148MP0000003_abnormal_adipose_tissue0.68479831
149MP0009278_abnormal_bone_marrow0.68368428
150MP0004142_abnormal_muscle_tone0.68141205
151MP0005508_abnormal_skeleton_morphology0.67773404
152MP0005058_abnormal_lysosome_morphology0.65012746
153MP0002161_abnormal_fertility/fecundity0.64968545
154MP0000537_abnormal_urethra_morphology0.64723905
155MP0005023_abnormal_wound_healing0.64536745
156MP0000681_abnormal_thyroid_gland0.63902896
157MP0003091_abnormal_cell_migration0.63758095
158MP0000767_abnormal_smooth_muscle0.63606213
159MP0005408_hypopigmentation0.63303146
160MP0003315_abnormal_perineum_morphology0.62691660
161MP0001614_abnormal_blood_vessel0.61198421
162MP0002295_abnormal_pulmonary_circulatio0.61165954
163MP0003453_abnormal_keratinocyte_physiol0.60126268

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)4.18557200
2Protrusio acetabuli (HP:0003179)4.16418494
3Myokymia (HP:0002411)3.92935754
4Premature rupture of membranes (HP:0001788)3.88888620
5Absent/shortened dynein arms (HP:0200106)3.54230838
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.54230838
7Purpura (HP:0000979)3.48792428
8Increased mean platelet volume (HP:0011877)3.33755101
9Abnormal gallbladder physiology (HP:0012438)3.31700586
10Cholecystitis (HP:0001082)3.31700586
11Visual hallucinations (HP:0002367)3.22374934
12Deep venous thrombosis (HP:0002625)3.17386763
13Abnormal platelet volume (HP:0011876)3.11666547
14Focal motor seizures (HP:0011153)3.11190565
15Supranuclear gaze palsy (HP:0000605)3.10078441
16Hypercortisolism (HP:0001578)3.04372124
17Disproportionate tall stature (HP:0001519)2.94354155
18Shallow orbits (HP:0000586)2.92019133
19Ankle clonus (HP:0011448)2.85792657
20Abnormality of the Achilles tendon (HP:0005109)2.84714350
21Prolonged bleeding time (HP:0003010)2.84080957
22Hyperthyroidism (HP:0000836)2.79011698
23Exercise-induced myalgia (HP:0003738)2.77740316
24Vertebral compression fractures (HP:0002953)2.77017757
25Focal seizures (HP:0007359)2.72866032
26Difficulty running (HP:0009046)2.72083010
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.64803682
28Sudden death (HP:0001699)2.62089887
29Bundle branch block (HP:0011710)2.60381890
30Upper limb amyotrophy (HP:0009129)2.57091325
31Distal upper limb amyotrophy (HP:0007149)2.57091325
32Exercise-induced muscle cramps (HP:0003710)2.50220834
33Distal lower limb amyotrophy (HP:0008944)2.49017147
34Cerebral inclusion bodies (HP:0100314)2.46101465
35Rapidly progressive (HP:0003678)2.38707346
36Turricephaly (HP:0000262)2.37702508
37Petechiae (HP:0000967)2.34388409
38Abnormality of the lower motor neuron (HP:0002366)2.33889047
39Renal duplication (HP:0000075)2.33046788
40Difficulty climbing stairs (HP:0003551)2.32295316
41Spinal rigidity (HP:0003306)2.29732358
42Truncus arteriosus (HP:0001660)2.28864091
43Nasal polyposis (HP:0100582)2.28560131
44Depression (HP:0000716)2.27863832
45Reticulocytosis (HP:0001923)2.27336192
46Biconcave vertebral bodies (HP:0004586)2.26040735
47Amyotrophic lateral sclerosis (HP:0007354)2.25479030
48Hand muscle atrophy (HP:0009130)2.24667534
49Mutism (HP:0002300)2.23027522
50Abnormal eating behavior (HP:0100738)2.21828721
51Atelectasis (HP:0100750)2.21206618
52Xanthomatosis (HP:0000991)2.20390656
53Neurofibrillary tangles (HP:0002185)2.19003171
54Asymmetric septal hypertrophy (HP:0001670)2.18834534
55Neoplasm of the heart (HP:0100544)2.18238208
56Annular pancreas (HP:0001734)2.15327677
57Dysmetric saccades (HP:0000641)2.15052508
58Abnormality of dentin (HP:0010299)2.14005494
59Infertility (HP:0000789)2.14001620
60Hyperparathyroidism (HP:0000843)2.11635533
61Bladder diverticulum (HP:0000015)2.10883102
62Ulnar bowing (HP:0003031)2.08544786
63Hypercholesterolemia (HP:0003124)2.08442018
64Myopathic facies (HP:0002058)2.08109026
65Increased variability in muscle fiber diameter (HP:0003557)2.06225771
66Insomnia (HP:0100785)2.05640584
67Amblyopia (HP:0000646)2.04984475
68Hyperacusis (HP:0010780)2.04948176
69Abnormality of the nasal mucosa (HP:0000433)2.04122976
70Arnold-Chiari malformation (HP:0002308)2.03438756
71Abnormality of the common coagulation pathway (HP:0010990)2.03046416
72Apathy (HP:0000741)2.02880568
73Cerebral aneurysm (HP:0004944)2.02685886
74Polycythemia (HP:0001901)2.01969378
75Joint hemorrhage (HP:0005261)2.00887188
76Abnormal respiratory epithelium morphology (HP:0012253)2.00189402
77Abnormal respiratory motile cilium morphology (HP:0005938)2.00189402
78Back pain (HP:0003418)1.99764409
79Abnormal platelet function (HP:0011869)1.99720247
80Impaired platelet aggregation (HP:0003540)1.99720247
81Primary atrial arrhythmia (HP:0001692)1.99593216
82Neuronal loss in central nervous system (HP:0002529)1.99304359
83Peripheral hypomyelination (HP:0007182)1.98752639
84Blue sclerae (HP:0000592)1.98654604
85Abnormal respiratory motile cilium physiology (HP:0012261)1.97273615
86Papilledema (HP:0001085)1.96512789
87Atrial fibrillation (HP:0005110)1.95368716
88Epileptic encephalopathy (HP:0200134)1.94642291
89Megalencephaly (HP:0001355)1.94604750
90Action tremor (HP:0002345)1.93892803
91Muscle hypertrophy of the lower extremities (HP:0008968)1.93718522
92Thin ribs (HP:0000883)1.92909711
93Epistaxis (HP:0000421)1.92209119
94Male infertility (HP:0003251)1.92096299
95Congenital glaucoma (HP:0001087)1.92055304
96Poor eye contact (HP:0000817)1.91599748
97Upper limb muscle weakness (HP:0003484)1.91201722
98Mitral regurgitation (HP:0001653)1.91200038
99Urinary bladder sphincter dysfunction (HP:0002839)1.91142878
100Hemiparesis (HP:0001269)1.91103244
101Calf muscle hypertrophy (HP:0008981)1.90020918
102Hyporeflexia of lower limbs (HP:0002600)1.89959555
103Postural instability (HP:0002172)1.89551002
104Impaired social interactions (HP:0000735)1.87960253
105Abnormal social behavior (HP:0012433)1.87960253
106Atonic seizures (HP:0010819)1.87841500
107Fragile skin (HP:0001030)1.87147135
108Failure to thrive in infancy (HP:0001531)1.87035871
109Hemorrhage of the eye (HP:0011885)1.86903005
110Lower limb amyotrophy (HP:0007210)1.86839676
111Supraventricular tachycardia (HP:0004755)1.86543269
112Long palpebral fissure (HP:0000637)1.86520661
113Overriding aorta (HP:0002623)1.86502597
114Bowel incontinence (HP:0002607)1.85303816
115Hyperextensible skin (HP:0000974)1.85287259
116Abnormal large intestine physiology (HP:0012700)1.85013553
117Supraventricular arrhythmia (HP:0005115)1.84444104
118Ventricular fibrillation (HP:0001663)1.83798883
119Diminished motivation (HP:0000745)1.83554531
120Abnormality of reticulocytes (HP:0004312)1.83270558
121Broad metatarsal (HP:0001783)1.82786395
122Gingival bleeding (HP:0000225)1.82442321
123Adrenal overactivity (HP:0002717)1.82262375
124Ankle contracture (HP:0006466)1.81521377
125Cervical subluxation (HP:0003308)1.81511571
126Truncal ataxia (HP:0002078)1.80942763
127Urinary urgency (HP:0000012)1.78439656
128Polyphagia (HP:0002591)1.78252727
129Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78183220
130Increased connective tissue (HP:0009025)1.77735448
131Vascular tortuosity (HP:0004948)1.76265216
132Insidious onset (HP:0003587)1.75750423
133Termporal pattern (HP:0011008)1.75750423
134Generalized hypotonia (HP:0001290)1.73610351
135Large eyes (HP:0001090)1.73267105
136Centrally nucleated skeletal muscle fibers (HP:0003687)1.73153781
137Distal lower limb muscle weakness (HP:0009053)1.72706505
138Prolonged QT interval (HP:0001657)1.72578874
139Abnormality of skeletal muscle fiber size (HP:0012084)1.72492069
140Myotonia (HP:0002486)1.72453632
141Abnormality of the calf musculature (HP:0001430)1.71940405
142Absent epiphyses (HP:0010577)1.71846749
143Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71846749
144Cholelithiasis (HP:0001081)1.71208328
145Neonatal short-limb short stature (HP:0008921)1.70970948
146Impaired pain sensation (HP:0007328)1.70775038
147Abnormality of pain sensation (HP:0010832)1.70775038
148Buphthalmos (HP:0000557)1.70735497
149Arterial tortuosity (HP:0005116)1.70158095
150Myoglobinuria (HP:0002913)1.69902510
151Rhinitis (HP:0012384)1.69850581
152Abnormal delivery (HP:0001787)1.69359748
153Peritonitis (HP:0002586)1.69181574
154Gaze-evoked nystagmus (HP:0000640)1.68816636
155Pointed chin (HP:0000307)1.67865511
156Abnormality of the tricuspid valve (HP:0001702)1.67807046
157Muscle fiber splitting (HP:0003555)1.67470288
158Abnormality of the aortic arch (HP:0012303)1.67133894
159Lower limb muscle weakness (HP:0007340)1.66865909
160Impaired vibration sensation in the lower limbs (HP:0002166)1.65623868
161Abnormality of binocular vision (HP:0011514)1.65463059
162Diplopia (HP:0000651)1.65463059
163Obstructive sleep apnea (HP:0002870)1.64752209
164Mildly elevated creatine phosphokinase (HP:0008180)1.64657713
165EMG: myopathic abnormalities (HP:0003458)1.63155902
166Renovascular hypertension (HP:0100817)1.62792613
167Abnormal EKG (HP:0003115)1.62276630
168Venous abnormality (HP:0002624)1.62209867
169Abnormality of the acetabulum (HP:0003170)1.62113971
170Partial duplication of thumb phalanx (HP:0009944)1.61845936
171Coronal craniosynostosis (HP:0004440)1.61269156
172Hypoventilation (HP:0002791)1.59391384
173Patellar dislocation (HP:0002999)1.59311446
174Ankyloglossia (HP:0010296)1.59306878
175Hammertoe (HP:0001765)1.58856475
176Achilles tendon contracture (HP:0001771)1.58256463
177Resting tremor (HP:0002322)1.57944677
178Abnormality of carpal bone ossification (HP:0006257)1.57645815
179Pheochromocytoma (HP:0002666)1.57517331
180Trigonocephaly (HP:0000243)1.57267371
181Hypercalcemia (HP:0003072)1.56956305
182Neonatal death (HP:0003811)1.56285045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.17048630
2PRKD33.98917225
3TESK12.95473915
4MAP3K92.94253163
5TRIB32.69809568
6SMG12.43440410
7SIK12.25883177
8PDK32.23337435
9PDK42.23337435
10MARK11.99722480
11PAK61.95530182
12NTRK31.95355835
13UHMK11.95097691
14KSR21.94591138
15FGFR41.85343177
16EPHA41.84597567
17STK381.81939342
18MINK11.79874412
19WNK41.67825657
20CDK121.62331794
21NTRK11.61420161
22PHKG21.58508759
23PHKG11.58508759
24TYRO31.56015694
25TTN1.48868644
26MAP3K111.47580807
27TAOK11.43770703
28CAMKK11.42420027
29PTK2B1.41138581
30PRPF4B1.40757239
31EEF2K1.40291577
32DMPK1.34808108
33NTRK21.32913658
34TAOK21.27160419
35PKN21.24760544
36BMX1.18988626
37PRKD21.17381306
38LMTK21.16711058
39IRAK31.16437161
40BRAF1.13856765
41ARAF1.11763360
42SIK21.11457555
43RIPK11.10964131
44PDK21.10893979
45EPHA21.09320932
46MAP2K31.07167590
47CDK51.06397329
48EIF2AK11.05716151
49DYRK1B1.05253045
50LATS21.05017312
51STK391.00319543
52RIPK40.99383323
53MUSK0.99293661
54DDR20.95506371
55CAMK1G0.93432530
56MARK20.93416511
57STK110.93041520
58WNK10.92893573
59KSR10.90570465
60PINK10.90461679
61ALK0.90339441
62MTOR0.84483446
63PDGFRA0.84255468
64VRK20.83916100
65NME20.82104186
66SCYL20.81513540
67FES0.80682291
68PDK10.79666603
69CDK70.78564309
70MYLK0.78542716
71BRSK10.77790792
72RET0.77216569
73MAP3K80.76748699
74CDK140.76514356
75MAP3K40.76193030
76CDK150.75279991
77PDPK10.74897779
78PRKCH0.74315151
79EPHB10.73096945
80CDK180.72187982
81MAP3K100.72173644
82DAPK20.71343501
83TNIK0.70691109
84FGR0.69802766
85LRRK20.68637443
86CDC42BPA0.68312929
87DYRK20.66489368
88CDK11A0.66240810
89MAP3K30.65251584
90ERN10.63453144
91PTK20.63356879
92PAK30.62805015
93GRK50.62538860
94TESK20.61915813
95CAMK10.61753270
96CAMK1D0.61541417
97RPS6KA20.60296226
98GRK60.60060495
99DAPK10.59129300
100PNCK0.57708685
101LIMK10.55406165
102MAP3K10.55094521
103DAPK30.53731872
104SIK30.52681823
105RAF10.52607405
106PRKG20.51983342
107PRKAA10.51877155
108PAK40.51769329
109ROCK20.50872621
110PAK20.50531123
111PTK60.49345078
112CDK190.49073736
113SGK30.48214248
114MAP3K20.46755955
115HIPK20.45877267
116ILK0.45691045
117NEK10.44558527
118MOS0.44555220
119PAK10.44176529
120ROCK10.42338297
121EPHB20.41665419
122CAMK2A0.41632260
123MATK0.40671027
124SGK10.39949424
125PRKD10.39947056
126AKT20.39335094
127PRKCG0.37951186
128AURKA0.37029099
129MAPK120.34880243
130MAP3K60.34878457

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.69640723
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29988045
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.28314703
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.24353783
5Biosynthesis of amino acids_Homo sapiens_hsa012302.11510749
6Synaptic vesicle cycle_Homo sapiens_hsa047212.09131147
7Sulfur relay system_Homo sapiens_hsa041221.83998605
8Long-term potentiation_Homo sapiens_hsa047201.80393679
9Galactose metabolism_Homo sapiens_hsa000521.79400475
10Gastric acid secretion_Homo sapiens_hsa049711.67297335
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66902724
12Pentose phosphate pathway_Homo sapiens_hsa000301.65760389
13Olfactory transduction_Homo sapiens_hsa047401.61957873
14Circadian entrainment_Homo sapiens_hsa047131.59892849
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58670464
16Prion diseases_Homo sapiens_hsa050201.54091612
17ECM-receptor interaction_Homo sapiens_hsa045121.51447970
18Cardiac muscle contraction_Homo sapiens_hsa042601.49307794
19Salivary secretion_Homo sapiens_hsa049701.48754249
20Amphetamine addiction_Homo sapiens_hsa050311.48699349
21Glutamatergic synapse_Homo sapiens_hsa047241.47561624
22Insulin secretion_Homo sapiens_hsa049111.44791683
23Nicotine addiction_Homo sapiens_hsa050331.42678412
24Notch signaling pathway_Homo sapiens_hsa043301.42570806
25Cholinergic synapse_Homo sapiens_hsa047251.42071742
26Dopaminergic synapse_Homo sapiens_hsa047281.40206886
27Carbon metabolism_Homo sapiens_hsa012001.36677658
28Fructose and mannose metabolism_Homo sapiens_hsa000511.36328492
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35640876
30GABAergic synapse_Homo sapiens_hsa047271.34622673
31Morphine addiction_Homo sapiens_hsa050321.33378060
32Thyroid cancer_Homo sapiens_hsa052161.32552852
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.30338846
34Oxytocin signaling pathway_Homo sapiens_hsa049211.29560873
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27594998
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26887876
37Dilated cardiomyopathy_Homo sapiens_hsa054141.25939587
38Renin secretion_Homo sapiens_hsa049241.25649514
39Dorso-ventral axis formation_Homo sapiens_hsa043201.25211427
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24595333
41Adherens junction_Homo sapiens_hsa045201.23493578
42VEGF signaling pathway_Homo sapiens_hsa043701.23058670
43Estrogen signaling pathway_Homo sapiens_hsa049151.22243794
44Gap junction_Homo sapiens_hsa045401.21327454
45Arginine and proline metabolism_Homo sapiens_hsa003301.21300072
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21246302
47Arginine biosynthesis_Homo sapiens_hsa002201.20083907
48Glioma_Homo sapiens_hsa052141.18161875
49Vitamin B6 metabolism_Homo sapiens_hsa007501.16590764
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16083703
51Cocaine addiction_Homo sapiens_hsa050301.15541674
52Axon guidance_Homo sapiens_hsa043601.12860717
53Fatty acid biosynthesis_Homo sapiens_hsa000611.12081962
54Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08402230
55GnRH signaling pathway_Homo sapiens_hsa049121.07835036
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.07238340
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05857669
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03948613
59Fatty acid elongation_Homo sapiens_hsa000621.03707783
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02824888
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02436125
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02001172
63Long-term depression_Homo sapiens_hsa047300.99682887
64Type II diabetes mellitus_Homo sapiens_hsa049300.99403922
65Calcium signaling pathway_Homo sapiens_hsa040200.99254114
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98957400
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98854483
68Bladder cancer_Homo sapiens_hsa052190.98206271
69ErbB signaling pathway_Homo sapiens_hsa040120.97577419
70Endometrial cancer_Homo sapiens_hsa052130.95195346
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94970329
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94635894
73Melanogenesis_Homo sapiens_hsa049160.93964065
74Endocytosis_Homo sapiens_hsa041440.93282239
75cAMP signaling pathway_Homo sapiens_hsa040240.93175251
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91991170
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91794653
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91089384
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90960286
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90951504
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90721037
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90597109
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.87657303
84* Phospholipase D signaling pathway_Homo sapiens_hsa040720.87506523
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86740567
86Pancreatic cancer_Homo sapiens_hsa052120.86263739
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86147928
88Collecting duct acid secretion_Homo sapiens_hsa049660.85380239
89mTOR signaling pathway_Homo sapiens_hsa041500.84397427
90Pyruvate metabolism_Homo sapiens_hsa006200.83815661
91Glucagon signaling pathway_Homo sapiens_hsa049220.83641798
92Serotonergic synapse_Homo sapiens_hsa047260.83058275
93Vibrio cholerae infection_Homo sapiens_hsa051100.82680457
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82621023
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.81786726
96Steroid biosynthesis_Homo sapiens_hsa001000.80944528
97Renal cell carcinoma_Homo sapiens_hsa052110.80165237
98Pancreatic secretion_Homo sapiens_hsa049720.78147542
99Bile secretion_Homo sapiens_hsa049760.77543946
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76278517
101Other glycan degradation_Homo sapiens_hsa005110.75553698
102Salmonella infection_Homo sapiens_hsa051320.75061103
103Insulin signaling pathway_Homo sapiens_hsa049100.74904719
104Oocyte meiosis_Homo sapiens_hsa041140.74307422
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74248109
106Non-small cell lung cancer_Homo sapiens_hsa052230.74047359
107Thyroid hormone synthesis_Homo sapiens_hsa049180.73920640
108Chronic myeloid leukemia_Homo sapiens_hsa052200.73469185
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.73209056
110Complement and coagulation cascades_Homo sapiens_hsa046100.72315189
111MAPK signaling pathway_Homo sapiens_hsa040100.71654309
112Choline metabolism in cancer_Homo sapiens_hsa052310.71642462
113Hippo signaling pathway_Homo sapiens_hsa043900.70503816
114Focal adhesion_Homo sapiens_hsa045100.69821701
115Wnt signaling pathway_Homo sapiens_hsa043100.68587121
116Taste transduction_Homo sapiens_hsa047420.68499196
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68257519
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.67347061
119N-Glycan biosynthesis_Homo sapiens_hsa005100.67313115
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66493968
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66399750
122Basal cell carcinoma_Homo sapiens_hsa052170.66352047
123Tight junction_Homo sapiens_hsa045300.65840469
124HIF-1 signaling pathway_Homo sapiens_hsa040660.65596346
125AMPK signaling pathway_Homo sapiens_hsa041520.64539446
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64509503
127Colorectal cancer_Homo sapiens_hsa052100.64182936
128PPAR signaling pathway_Homo sapiens_hsa033200.63453267
129Rap1 signaling pathway_Homo sapiens_hsa040150.62555085
130Fatty acid metabolism_Homo sapiens_hsa012120.62547023
131Inositol phosphate metabolism_Homo sapiens_hsa005620.61400983
132Hedgehog signaling pathway_Homo sapiens_hsa043400.60997017
133Mineral absorption_Homo sapiens_hsa049780.60245461
134Acute myeloid leukemia_Homo sapiens_hsa052210.59635447
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59303778
136Proteoglycans in cancer_Homo sapiens_hsa052050.58541089
137Amoebiasis_Homo sapiens_hsa051460.58520798
138* Fat digestion and absorption_Homo sapiens_hsa049750.58292392
139Glutathione metabolism_Homo sapiens_hsa004800.56205665
140Viral myocarditis_Homo sapiens_hsa054160.54201654
141Platelet activation_Homo sapiens_hsa046110.53560466
142Chemokine signaling pathway_Homo sapiens_hsa040620.53247192
143Protein digestion and absorption_Homo sapiens_hsa049740.49279249
144MicroRNAs in cancer_Homo sapiens_hsa052060.48027565
145Prostate cancer_Homo sapiens_hsa052150.47360459

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