AGPAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NADH metabolic process (GO:0006734)5.93970796
2L-phenylalanine catabolic process (GO:0006559)5.84514308
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.84514308
4L-phenylalanine metabolic process (GO:0006558)5.74902611
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.74902611
6alpha-linolenic acid metabolic process (GO:0036109)5.58790479
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.57272109
8sulfur amino acid catabolic process (GO:0000098)5.27556047
9regulation of triglyceride catabolic process (GO:0010896)5.25260365
10aromatic amino acid family catabolic process (GO:0009074)5.16146232
11diacylglycerol metabolic process (GO:0046339)5.01006839
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.95358606
13urea cycle (GO:0000050)4.77709398
14urea metabolic process (GO:0019627)4.77709398
15complement activation, alternative pathway (GO:0006957)4.76868315
16cysteine metabolic process (GO:0006534)4.72073625
17glyoxylate metabolic process (GO:0046487)4.65380272
18biotin metabolic process (GO:0006768)4.64589587
19low-density lipoprotein particle clearance (GO:0034383)4.63909568
20plasma lipoprotein particle clearance (GO:0034381)4.61598358
21amino-acid betaine metabolic process (GO:0006577)4.60654017
22bile acid biosynthetic process (GO:0006699)4.59539828
23fatty acid beta-oxidation (GO:0006635)4.59461853
24indole-containing compound catabolic process (GO:0042436)4.57186688
25indolalkylamine catabolic process (GO:0046218)4.57186688
26tryptophan catabolic process (GO:0006569)4.57186688
27regulation of sequestering of triglyceride (GO:0010889)4.55970296
28valine metabolic process (GO:0006573)4.54863549
29acylglycerol homeostasis (GO:0055090)4.53499071
30triglyceride homeostasis (GO:0070328)4.53499071
31serine family amino acid catabolic process (GO:0009071)4.52469559
32kynurenine metabolic process (GO:0070189)4.52393812
33angiotensin maturation (GO:0002003)4.46411384
34acetyl-CoA metabolic process (GO:0006084)4.45996457
35nitrogen cycle metabolic process (GO:0071941)4.44798030
36fatty acid transmembrane transport (GO:1902001)4.35043892
37regulation of protein activation cascade (GO:2000257)4.33271889
38fatty acid oxidation (GO:0019395)4.32545537
39positive regulation of fatty acid beta-oxidation (GO:0032000)4.32443032
40lysine metabolic process (GO:0006553)4.31609671
41lysine catabolic process (GO:0006554)4.31609671
42high-density lipoprotein particle remodeling (GO:0034375)4.31133757
43tryptophan metabolic process (GO:0006568)4.30384625
44fatty acid catabolic process (GO:0009062)4.25163539
45negative regulation of fibrinolysis (GO:0051918)4.24716795
46lipid oxidation (GO:0034440)4.23451734
47positive regulation of lipid catabolic process (GO:0050996)4.20709276
48triglyceride catabolic process (GO:0019433)4.18649992
49homocysteine metabolic process (GO:0050667)4.18561368
50protein carboxylation (GO:0018214)4.14482011
51peptidyl-glutamic acid carboxylation (GO:0017187)4.14482011
52regulation of complement activation (GO:0030449)4.11406496
53bile acid metabolic process (GO:0008206)4.10692409
54acylglycerol catabolic process (GO:0046464)4.02880079
55neutral lipid catabolic process (GO:0046461)4.02880079
56regulation of fibrinolysis (GO:0051917)4.00084689
57protein-lipid complex remodeling (GO:0034368)3.96535086
58macromolecular complex remodeling (GO:0034367)3.96535086
59plasma lipoprotein particle remodeling (GO:0034369)3.96535086
60regulation of cholesterol esterification (GO:0010872)3.95793076
61carnitine shuttle (GO:0006853)3.95202527
62glycine metabolic process (GO:0006544)3.92143279
63monocarboxylic acid catabolic process (GO:0072329)3.90878459
64alpha-amino acid catabolic process (GO:1901606)3.90348799
65reverse cholesterol transport (GO:0043691)3.90040237
66branched-chain amino acid catabolic process (GO:0009083)3.89101078
67fatty acid homeostasis (GO:0055089)3.87747306
68aromatic amino acid family metabolic process (GO:0009072)3.86811016
69carnitine metabolic process (GO:0009437)3.85526195
70positive regulation of fatty acid oxidation (GO:0046321)3.85266533
71ethanol oxidation (GO:0006069)3.83609612
72phospholipid efflux (GO:0033700)3.81240859
73positive regulation of triglyceride metabolic process (GO:0090208)3.79674444
74positive regulation of triglyceride lipase activity (GO:0061365)3.76192133
75positive regulation of lipoprotein lipase activity (GO:0051006)3.76192133
762-oxoglutarate metabolic process (GO:0006103)3.75603897
77tyrosine metabolic process (GO:0006570)3.74794266
78short-chain fatty acid metabolic process (GO:0046459)3.74441262
79cellular amino acid catabolic process (GO:0009063)3.73287932
80lipid storage (GO:0019915)3.70312237
81carboxylic acid catabolic process (GO:0046395)3.68498298
82organic acid catabolic process (GO:0016054)3.68498298
83serine family amino acid metabolic process (GO:0009069)3.68268867
84regulation of cholesterol storage (GO:0010885)3.68092203
85branched-chain amino acid metabolic process (GO:0009081)3.67635845
86phospholipid homeostasis (GO:0055091)3.67261173
87oxaloacetate metabolic process (GO:0006107)3.66743783
88regulation of fatty acid beta-oxidation (GO:0031998)3.62621860
89regulation of triglyceride metabolic process (GO:0090207)3.61391809
90cellular ketone body metabolic process (GO:0046950)3.58600577
91thioester biosynthetic process (GO:0035384)3.55686709
92acyl-CoA biosynthetic process (GO:0071616)3.55686709
93negative regulation of fatty acid biosynthetic process (GO:0045717)3.54760453
94glycerolipid catabolic process (GO:0046503)3.54493628
95negative regulation of lipase activity (GO:0060192)3.52974363
96negative regulation of cholesterol transport (GO:0032375)3.52092516
97negative regulation of sterol transport (GO:0032372)3.52092516
98fatty-acyl-CoA biosynthetic process (GO:0046949)3.50400433
99coenzyme catabolic process (GO:0009109)3.49452571
100plasma lipoprotein particle assembly (GO:0034377)3.48975389
101bile acid and bile salt transport (GO:0015721)3.48649458
102transcytosis (GO:0045056)3.48616482
103cholesterol homeostasis (GO:0042632)3.48528061
104serine family amino acid biosynthetic process (GO:0009070)3.47708491
105regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.45590157
106sterol homeostasis (GO:0055092)3.42492218
107regulation of fatty acid oxidation (GO:0046320)3.41725923
108* triglyceride metabolic process (GO:0006641)3.39346108
109regulation of cholesterol metabolic process (GO:0090181)3.38844688
110ethanol metabolic process (GO:0006067)3.38672331
111regulation of cholesterol homeostasis (GO:2000188)3.37218321
112barbed-end actin filament capping (GO:0051016)3.30112175
113* triglyceride biosynthetic process (GO:0019432)3.25121181
114tricarboxylic acid metabolic process (GO:0072350)3.19054447
115fructose metabolic process (GO:0006000)3.15416504
116* neutral lipid biosynthetic process (GO:0046460)3.08517452
117* acylglycerol biosynthetic process (GO:0046463)3.08517452
118* acylglycerol metabolic process (GO:0006639)3.07168923
119positive regulation of cholesterol efflux (GO:0010875)3.05560321
120* neutral lipid metabolic process (GO:0006638)3.01117285
121intestinal absorption (GO:0050892)2.99935388
122primary alcohol metabolic process (GO:0034308)2.95960821
123negative regulation of granulocyte differentiation (GO:0030853)2.95162799
124lipoprotein transport (GO:0042953)2.94126014
125positive regulation of fatty acid biosynthetic process (GO:0045723)2.88725418
126fat-soluble vitamin biosynthetic process (GO:0042362)2.79795467
127regulation of cholesterol transport (GO:0032374)2.78179035
128regulation of sterol transport (GO:0032371)2.78179035
129positive regulation of fatty acid metabolic process (GO:0045923)2.77992453
130adhesion of symbiont to host cell (GO:0044650)2.76735982
131virion attachment to host cell (GO:0019062)2.76735982
132epoxygenase P450 pathway (GO:0019373)2.75697206
133primary alcohol catabolic process (GO:0034310)2.73076233
134cellular response to cadmium ion (GO:0071276)2.72050893
135brown fat cell differentiation (GO:0050873)2.71978297
136long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.69842585
137adhesion of symbiont to host (GO:0044406)2.68991712
138daunorubicin metabolic process (GO:0044597)2.66944141
139polyketide metabolic process (GO:0030638)2.66944141
140doxorubicin metabolic process (GO:0044598)2.66944141
141positive regulation of cholesterol transport (GO:0032376)2.64436451
142positive regulation of sterol transport (GO:0032373)2.64436451
143very long-chain fatty acid metabolic process (GO:0000038)2.63677244
144glycerol metabolic process (GO:0006071)2.61950926
145alditol metabolic process (GO:0019400)2.61948855
146positive regulation of Cdc42 GTPase activity (GO:0043089)2.61409961
147negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.61154317
148fatty-acyl-CoA metabolic process (GO:0035337)2.60540938
149response to phenylpropanoid (GO:0080184)2.52756947
150regulation of lipid catabolic process (GO:0050994)2.52575391
151positive regulation of lipid storage (GO:0010884)2.51912939
152positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.49112551
153negative regulation of erythrocyte differentiation (GO:0045647)2.48468742
154white fat cell differentiation (GO:0050872)2.47480897
155very-low-density lipoprotein particle assembly (GO:0034379)2.47122360
156retinol metabolic process (GO:0042572)2.45727197
157proline biosynthetic process (GO:0006561)2.45500821
158glycosphingolipid catabolic process (GO:0046479)2.44613210
159glomerular filtration (GO:0003094)2.41275325
160regulation of macrophage derived foam cell differentiation (GO:0010743)2.41187664
161GDP-mannose metabolic process (GO:0019673)2.41090296
162negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.39868280
163response to hydroperoxide (GO:0033194)2.38776112
164regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.37691033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.38204731
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.71036335
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.73602286
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.00868107
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.17854881
6EGR1_23403033_ChIP-Seq_LIVER_Mouse5.04111310
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.24647112
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.12449151
9* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.82621301
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.23800484
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.13825265
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58358763
13VDR_21846776_ChIP-Seq_THP-1_Human2.44191108
14CLOCK_20551151_ChIP-Seq_293T_Human2.40860483
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.07616718
16KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70192709
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.70105753
18ZNF263_19887448_ChIP-Seq_K562_Human1.68477433
19VDR_24763502_ChIP-Seq_THP-1_Human1.68132995
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66474237
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65866444
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.62526154
23GATA1_22025678_ChIP-Seq_K562_Human1.54475816
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54257731
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52601015
26SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50876728
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.49832714
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47884328
29* P68_20966046_ChIP-Seq_HELA_Human1.44071514
30* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42309429
31SA1_27219007_Chip-Seq_ERYTHROID_Human1.36966621
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32635916
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32508359
34KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30983978
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30938849
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.28959127
37TCF7_22412390_ChIP-Seq_EML_Mouse1.28512990
38KDM2B_26808549_Chip-Seq_DND41_Human1.27401127
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25056824
40SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24969837
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.24744279
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23320816
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23165237
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18808800
45P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17656673
46* SMC4_20622854_ChIP-Seq_HELA_Human1.16255875
47* HNF4A_19822575_ChIP-Seq_HepG2_Human1.14475557
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.13244864
49SA1_27219007_Chip-Seq_Bcells_Human1.12683546
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10941737
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10611950
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10347738
53* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09524536
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.09395402
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08746331
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.08413354
57SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07966924
58KDM2B_26808549_Chip-Seq_K562_Human1.07873889
59CTCF_26484167_Chip-Seq_Bcells_Mouse1.07423060
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.05675421
61* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05332047
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03950974
63* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03103311
64* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02920618
65MYC_22102868_ChIP-Seq_BL_Human1.02810544
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02466040
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02220472
68CTCF_27219007_Chip-Seq_Bcells_Human1.01830965
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01712303
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00852537
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00508892
72PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98708370
73* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97705997
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97654365
75GATA4_25053715_ChIP-Seq_YYC3_Human0.97416690
76NCOR1_26117541_ChIP-Seq_K562_Human0.97367253
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97310503
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97001141
79CREB1_26743006_Chip-Seq_LNCaP_Human0.96778159
80PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96600863
81ETS1_21867929_ChIP-Seq_TH2_Mouse0.96198484
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96194701
83* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95820778
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95360892
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95032920
86CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94501421
87CTCF_21964334_Chip-Seq_Bcells_Human0.94383894
88P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94100774
89SOX2_20726797_ChIP-Seq_SW620_Human0.94048117
90HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93717746
91SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92995923
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86712664
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85776958
94RARA_24833708_ChIP-Seq_LIVER_Mouse0.79087846
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77894492
96* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75786918
97MYB_21317192_ChIP-Seq_ERMYB_Mouse0.75487189
98SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75140494
99AR_21909140_ChIP-Seq_LNCAP_Human0.73856175
100* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.73348608
101LXR_22292898_ChIP-Seq_THP-1_Human0.73302981
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72471323
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71969106
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71774858
105* RARB_24833708_ChIP-Seq_LIVER_Mouse0.71582094
106BCOR_27268052_Chip-Seq_Bcells_Human0.70600450
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70266005
108ESR2_21235772_ChIP-Seq_MCF-7_Human0.69222254
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.68898467
110HTT_18923047_ChIP-ChIP_STHdh_Human0.68043777
111ATF3_27146783_Chip-Seq_COLON_Human0.67947269
112RACK7_27058665_Chip-Seq_MCF-7_Human0.67295387
113KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67013677
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66838588
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66687581
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.66023839
117CEBPB_22108803_ChIP-Seq_LS180_Human0.65269520
118BCL6_27268052_Chip-Seq_Bcells_Human0.63584579
119* TET1_21451524_ChIP-Seq_MESCs_Mouse0.63210396
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62908715
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.60247820
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.59005581
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.58790237
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.58264222
125GATA6_25053715_ChIP-Seq_YYC3_Human0.58126156
126CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.57892185
127* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.57335818
128* P300_27268052_Chip-Seq_Bcells_Human0.57195908
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.57035093
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.56647401
131AUTS2_25519132_ChIP-Seq_293T-REX_Human0.56439215
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.56013081
133* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.55639256
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.55422447
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.54836218
136* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.54425537
137* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.54343934
138GATA2_22383799_ChIP-Seq_G1ME_Mouse0.54323733
139GATA1_19941826_ChIP-Seq_K562_Human0.52493515
140NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.52473727
141SRF_21415370_ChIP-Seq_HL-1_Mouse0.52322082
142GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.51847120
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.51796856
144JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.51282462
145PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.51195172
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.51145351
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.50410325
148CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.50314517
149PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.49982147
150* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.49561536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.64859456
2MP0005360_urolithiasis6.16435197
3MP0005365_abnormal_bile_salt5.29504633
4MP0005085_abnormal_gallbladder_physiolo4.93532994
5MP0010329_abnormal_lipoprotein_level3.86345098
6MP0008875_abnormal_xenobiotic_pharmacok3.75812774
7MP0005670_abnormal_white_adipose3.73654733
8MP0003806_abnormal_nucleotide_metabolis3.58403191
9MP0009840_abnormal_foam_cell3.49160953
10MP0003252_abnormal_bile_duct2.91366816
11MP0003191_abnormal_cellular_cholesterol2.88730352
12MP0005332_abnormal_amino_acid2.58864322
13MP0005666_abnormal_adipose_tissue2.42963203
14* MP0002118_abnormal_lipid_homeostasis2.40385483
15MP0001666_abnormal_nutrient_absorption2.35517201
16* MP0000609_abnormal_liver_physiology2.30815662
17MP0004130_abnormal_muscle_cell2.25816634
18MP0005083_abnormal_biliary_tract2.04743710
19MP0004019_abnormal_vitamin_homeostasis1.99076006
20MP0005319_abnormal_enzyme/_coenzyme1.91112401
21MP0003195_calcinosis1.90533517
22MP0010234_abnormal_vibrissa_follicle1.89042148
23MP0003186_abnormal_redox_activity1.86176545
24MP0004185_abnormal_adipocyte_glucose1.84640339
25MP0001764_abnormal_homeostasis1.80488104
26MP0003705_abnormal_hypodermis_morpholog1.71330259
27* MP0002971_abnormal_brown_adipose1.65029171
28MP0005584_abnormal_enzyme/coenzyme_acti1.62010129
29MP0004858_abnormal_nervous_system1.52687535
30MP0005375_adipose_tissue_phenotype1.48031486
31MP0009643_abnormal_urine_homeostasis1.43244579
32MP0000858_altered_metastatic_potential1.42669726
33MP0006036_abnormal_mitochondrial_physio1.41944913
34MP0002876_abnormal_thyroid_physiology1.40458394
35MP0003303_peritoneal_inflammation1.39964789
36MP0002837_dystrophic_cardiac_calcinosis1.39960804
37* MP0005334_abnormal_fat_pad1.35296083
38MP0009115_abnormal_fat_cell1.35068409
39MP0003828_pulmonary_edema1.31667564
40MP0010155_abnormal_intestine_physiology1.28871682
41MP0001661_extended_life_span1.27446390
42MP0003075_altered_response_to1.23921922
43MP0005451_abnormal_body_composition1.21400633
44MP0008438_abnormal_cutaneous_collagen1.20528126
45MP0002138_abnormal_hepatobiliary_system1.20515398
46MP0009379_abnormal_foot_pigmentation1.19237464
47MP0003011_delayed_dark_adaptation1.19210672
48* MP0000598_abnormal_liver_morphology1.19173154
49MP0008260_abnormal_autophagy1.17364042
50MP0003868_abnormal_feces_composition1.15932515
51MP0009697_abnormal_copulation1.14687771
52MP0003724_increased_susceptibility_to1.11249770
53MP0001533_abnormal_skeleton_physiology1.10251734
54MP0001545_abnormal_hematopoietic_system1.08905631
55MP0005397_hematopoietic_system_phenotyp1.08905631
56MP0005409_darkened_coat_color1.08540850
57* MP0002970_abnormal_white_adipose1.07486914
58MP0003453_abnormal_keratinocyte_physiol1.07224055
59MP0003183_abnormal_peptide_metabolism1.06978168
60MP0005166_decreased_susceptibility_to1.05264040
61MP0009278_abnormal_bone_marrow1.05127331
62MP0003656_abnormal_erythrocyte_physiolo1.04324532
63MP0002254_reproductive_system_inflammat1.03143981
64MP0009763_increased_sensitivity_to1.02220483
65MP0005448_abnormal_energy_balance1.01924703
66* MP0002078_abnormal_glucose_homeostasis1.01627316
67* MP0005535_abnormal_body_temperature1.01146395
68MP0005501_abnormal_skin_physiology1.00149649
69MP0003566_abnormal_cell_adhesion0.98461294
70MP0005165_increased_susceptibility_to0.96781968
71MP0005025_abnormal_response_to0.95628843
72MP0004272_abnormal_basement_membrane0.95014164
73MP0002419_abnormal_innate_immunity0.94816089
74MP0008469_abnormal_protein_level0.94127535
75MP0001756_abnormal_urination0.93469123
76MP0002998_abnormal_bone_remodeling0.87821288
77MP0005647_abnormal_sex_gland0.87595903
78* MP0009642_abnormal_blood_homeostasis0.86297168
79MP0000678_abnormal_parathyroid_gland0.86224360
80MP0003279_aneurysm0.85932125
81MP0005376_homeostasis/metabolism_phenot0.85378512
82MP0009764_decreased_sensitivity_to0.84928854
83MP0002877_abnormal_melanocyte_morpholog0.84671872
84MP0003300_gastrointestinal_ulcer0.82080234
85MP0003329_amyloid_beta_deposits0.81560308
86MP0004947_skin_inflammation0.80701088
87MP0003866_abnormal_defecation0.79774615
88MP0000490_abnormal_crypts_of0.79505379
89MP0000604_amyloidosis0.78926855
90MP0009333_abnormal_splenocyte_physiolog0.78092115
91MP0002796_impaired_skin_barrier0.77906596
92MP0002148_abnormal_hypersensitivity_rea0.77661573
93MP0005266_abnormal_metabolism0.76870217
94MP0005636_abnormal_mineral_homeostasis0.75857074
95MP0000751_myopathy0.75787571
96MP0005076_abnormal_cell_differentiation0.75314215
97MP0003448_altered_tumor_morphology0.74894147
98MP0001849_ear_inflammation0.74867889
99MP0005275_abnormal_skin_tensile0.72977788
100MP0001853_heart_inflammation0.72349210
101MP0001727_abnormal_embryo_implantation0.70995359
102MP0001881_abnormal_mammary_gland0.70901815
103MP0006035_abnormal_mitochondrial_morpho0.68568981
104MP0005058_abnormal_lysosome_morphology0.68078761
105MP0010368_abnormal_lymphatic_system0.67125314
106MP0005084_abnormal_gallbladder_morpholo0.66740524
107MP0000003_abnormal_adipose_tissue0.66708752
108MP0003436_decreased_susceptibility_to0.63025583
109MP0003959_abnormal_lean_body0.62914816
110MP0002060_abnormal_skin_morphology0.62755805
111MP0003690_abnormal_glial_cell0.62571451
112MP0003646_muscle_fatigue0.62475201
113MP0004782_abnormal_surfactant_physiolog0.62349967
114MP0009765_abnormal_xenobiotic_induced0.61932343
115MP0000013_abnormal_adipose_tissue0.60321846
116MP0002136_abnormal_kidney_physiology0.60190732
117* MP0003953_abnormal_hormone_level0.55392933
118* MP0005452_abnormal_adipose_tissue0.55286516
119MP0005395_other_phenotype0.54910171
120MP0005464_abnormal_platelet_physiology0.54635255
121MP0003718_maternal_effect0.52008368
122MP0003221_abnormal_cardiomyocyte_apopto0.50325288
123MP0005330_cardiomyopathy0.50044389
124MP0000249_abnormal_blood_vessel0.49517387
125MP0006138_congestive_heart_failure0.47162481
126MP0009672_abnormal_birth_weight0.47113944
127MP0005164_abnormal_response_to0.44963205
128MP0004264_abnormal_extraembryonic_tissu0.43149969
129MP0000343_altered_response_to0.42961629
130MP0005220_abnormal_exocrine_pancreas0.41664426
131MP0005023_abnormal_wound_healing0.41231358
132MP0002168_other_aberrant_phenotype0.41069601
133MP0004147_increased_porphyrin_level0.40940436
134MP0000230_abnormal_systemic_arterial0.39985817
135MP0005385_cardiovascular_system_phenoty0.39502715
136MP0001544_abnormal_cardiovascular_syste0.39502715
137MP0008873_increased_physiological_sensi0.38965710
138MP0001845_abnormal_inflammatory_respons0.38536913
139MP0009785_altered_susceptibility_to0.38272169

Predicted human phenotypes

RankGene SetZ-score
1Xanthomatosis (HP:0000991)5.79352200
2Hyperglycinuria (HP:0003108)5.69873506
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.64200898
4Deep venous thrombosis (HP:0002625)5.51724993
5Intrahepatic cholestasis (HP:0001406)5.50103084
6Hyperlipoproteinemia (HP:0010980)5.25814267
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.16249444
8Abnormality of glycine metabolism (HP:0010895)5.11814160
9Abnormality of serine family amino acid metabolism (HP:0010894)5.11814160
10Hypobetalipoproteinemia (HP:0003563)5.02948901
11Hyperammonemia (HP:0001987)4.95037752
12Complement deficiency (HP:0004431)4.89317495
13Hyperglycinemia (HP:0002154)4.85080811
14Prolonged partial thromboplastin time (HP:0003645)4.71583551
15Hypoglycemic coma (HP:0001325)4.66832007
16Abnormality of fatty-acid metabolism (HP:0004359)4.50655444
17Hypolipoproteinemia (HP:0010981)4.46694163
18Hypoalphalipoproteinemia (HP:0003233)4.43666020
19Ketosis (HP:0001946)4.37536699
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26623144
21Epidermoid cyst (HP:0200040)4.14388051
22Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.13519056
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09614481
24Abnormality of dicarboxylic acid metabolism (HP:0010995)3.76430822
25Dicarboxylic aciduria (HP:0003215)3.76430822
26Abnormality of complement system (HP:0005339)3.61617684
27Abnormality of the common coagulation pathway (HP:0010990)3.46268925
28Joint hemorrhage (HP:0005261)3.45686872
29Ketoacidosis (HP:0001993)3.42094259
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.39804119
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.36066843
32Abnormality of serum amino acid levels (HP:0003112)3.33614318
33Vertebral compression fractures (HP:0002953)3.33271218
34Hypercholesterolemia (HP:0003124)3.32882947
35Fat malabsorption (HP:0002630)3.15132766
36Axonal loss (HP:0003447)3.12869480
37Abnormality of methionine metabolism (HP:0010901)3.12016610
38Myocardial infarction (HP:0001658)3.05693232
39Abnormality of the intrinsic pathway (HP:0010989)3.04389055
40Lethargy (HP:0001254)3.04052410
41Abnormality of pyrimidine metabolism (HP:0004353)3.01235013
42* Hypertriglyceridemia (HP:0002155)2.93980333
43Abnormality of proline metabolism (HP:0010907)2.89600907
44Hydroxyprolinuria (HP:0003080)2.89600907
45Generalized aminoaciduria (HP:0002909)2.85752032
46Metabolic acidosis (HP:0001942)2.82304355
47Abnormality of nucleobase metabolism (HP:0010932)2.81322439
48Protrusio acetabuli (HP:0003179)2.79784290
49Nausea (HP:0002018)2.79587062
50Abnormality of liposaccharide metabolism (HP:0010968)2.74390482
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.74390482
52Abnormality of glycolipid metabolism (HP:0010969)2.74390482
53Dysostosis multiplex (HP:0000943)2.73107609
54Abnormality of purine metabolism (HP:0004352)2.71366153
55Skin nodule (HP:0200036)2.70265803
56Myoglobinuria (HP:0002913)2.66500920
57Hyperbilirubinemia (HP:0002904)2.63558977
58Systemic lupus erythematosus (HP:0002725)2.62313185
59Delayed CNS myelination (HP:0002188)2.60516538
60Cerebral edema (HP:0002181)2.59244718
61Eczematoid dermatitis (HP:0000976)2.57666900
62Abnormal cartilage morphology (HP:0002763)2.52613415
63Oligomenorrhea (HP:0000876)2.52587835
64Rhabdomyolysis (HP:0003201)2.51840152
65Conjugated hyperbilirubinemia (HP:0002908)2.46453627
66Vomiting (HP:0002013)2.39238117
67Increased muscle lipid content (HP:0009058)2.38900833
68* Pancreatitis (HP:0001733)2.35211220
69Brushfield spots (HP:0001088)2.34536713
70Increased variability in muscle fiber diameter (HP:0003557)2.30432074
71Steatorrhea (HP:0002570)2.29486062
72Hepatocellular carcinoma (HP:0001402)2.28908230
73Abnormality of polysaccharide metabolism (HP:0011012)2.28810470
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28810470
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28810470
76Hemorrhage of the eye (HP:0011885)2.27708479
77Urinary glycosaminoglycan excretion (HP:0003541)2.26481050
78Mucopolysacchariduria (HP:0008155)2.26481050
79Hyperparathyroidism (HP:0000843)2.26388837
80Hypoglycemic seizures (HP:0002173)2.25864429
81Spastic diplegia (HP:0001264)2.24300932
82Proximal tubulopathy (HP:0000114)2.22380380
83Renal cortical cysts (HP:0000803)2.22310147
84Colitis (HP:0002583)2.22015129
85Hepatosplenomegaly (HP:0001433)2.20478467
86Hepatic necrosis (HP:0002605)2.19566702
87Cervical subluxation (HP:0003308)2.19158005
88Distal lower limb muscle weakness (HP:0009053)2.18938582
89Premature rupture of membranes (HP:0001788)2.18240648
90Increased connective tissue (HP:0009025)2.18132578
91Subcapsular cataract (HP:0000523)2.17994220
92Hyperglycemia (HP:0003074)2.16219518
93Polygenic inheritance (HP:0010982)2.15953999
94Irritability (HP:0000737)2.15235175
95Spontaneous abortion (HP:0005268)2.15176079
96Gout (HP:0001997)2.14862503
97Thin bony cortex (HP:0002753)2.14075070
98Esophageal varix (HP:0002040)2.12322110
99Abnormality of skeletal muscle fiber size (HP:0012084)2.07174675
100Multiple enchondromatosis (HP:0005701)2.07065345
101Recurrent gram-negative bacterial infections (HP:0005420)2.06249334
102Malnutrition (HP:0004395)2.05563408
103Purpura (HP:0000979)2.05561223
104Nephritis (HP:0000123)2.04431406
105Gastrointestinal dysmotility (HP:0002579)2.01012766
106Stridor (HP:0010307)2.00961815
107Acanthocytosis (HP:0001927)2.00617665
108Elevated hepatic transaminases (HP:0002910)2.00161883
109* Insulin resistance (HP:0000855)1.99951058
110Late onset (HP:0003584)1.99428445
111Amyloidosis (HP:0011034)1.98289276
112Gingivitis (HP:0000230)1.95292514
113* Acanthosis nigricans (HP:0000956)1.95059508
114Distal lower limb amyotrophy (HP:0008944)1.94540531
115Asymmetric septal hypertrophy (HP:0001670)1.93931520
116Cholelithiasis (HP:0001081)1.93729852
117Abnormal gallbladder morphology (HP:0012437)1.93228721
118Vacuolated lymphocytes (HP:0001922)1.92819424
119Multiple lipomas (HP:0001012)1.92664859
120Abnormality of the nasal mucosa (HP:0000433)1.92155093
121Wide cranial sutures (HP:0010537)1.91499794
122Abnormality of macrophages (HP:0004311)1.91182508
123Cerebral palsy (HP:0100021)1.90764309
124Neonatal onset (HP:0003623)1.90763312
125Widely patent fontanelles and sutures (HP:0004492)1.90546837
126Hypercortisolism (HP:0001578)1.90390067
127Glomerulonephritis (HP:0000099)1.89854836
128Petechiae (HP:0000967)1.89809430
129Bulbar palsy (HP:0001283)1.89191671
130Hypophosphatemia (HP:0002148)1.89125058
131Sensorimotor neuropathy (HP:0007141)1.88267222
132Polycythemia (HP:0001901)1.88097826
133Ragged-red muscle fibers (HP:0003200)1.87661933
134Abnormality of iron homeostasis (HP:0011031)1.87586413
135Hyperuricemia (HP:0002149)1.87322024
136Increased purine levels (HP:0004368)1.87322024
137Ileus (HP:0002595)1.86067637
138Hyperinsulinemic hypoglycemia (HP:0000825)1.85317431
139Abnormality of transition element cation homeostasis (HP:0011030)1.85186079
140Glycosuria (HP:0003076)1.84260380
141Abnormality of urine glucose concentration (HP:0011016)1.84260380
142Reduced subcutaneous adipose tissue (HP:0003758)1.82528291
143Loss of speech (HP:0002371)1.82397606
144Increased serum ferritin (HP:0003281)1.81447606
145Vascular calcification (HP:0004934)1.80660453
146Pigmentary retinal degeneration (HP:0001146)1.80170145
147Back pain (HP:0003418)1.79921718
148Achilles tendon contracture (HP:0001771)1.79338863
149Methylmalonic aciduria (HP:0012120)1.79249052
150Opisthotonus (HP:0002179)1.78784925
151Abdominal distention (HP:0003270)1.78012416
152Abnormality of the Achilles tendon (HP:0005109)1.78010800
153Bone pain (HP:0002653)1.77371388
154Easy fatigability (HP:0003388)1.75741939
155Cerebral aneurysm (HP:0004944)1.75505006
156Prolonged neonatal jaundice (HP:0006579)1.73649755
157Increased cerebral lipofuscin (HP:0011813)1.73229197
158Abnormality of carpal bone ossification (HP:0006257)1.72929321
159Spinal rigidity (HP:0003306)1.69539306
160Pathologic fracture (HP:0002756)1.69301139
161Osteolytic defects of the hand bones (HP:0009699)1.69251956
162Osteolytic defects of the phalanges of the hand (HP:0009771)1.69251956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.84104620
2TRIB34.07283382
3SIK14.00394669
4ERN13.86454152
5CAMK1D3.72904859
6FGFR42.82881978
7TESK12.82007026
8PDK32.70526617
9PDK42.70526617
10EPHB22.22894800
11MST1R2.22059424
12PKN22.09916187
13CAMK1G2.06850197
14PRPF4B2.06505994
15FLT31.97192657
16SMG11.94994757
17PDK21.73406591
18INSRR1.73261646
19EPHA21.69980861
20DDR21.62206524
21IRAK31.58936493
22PRKAA21.54436550
23RIPK41.48324592
24ARAF1.47209395
25KDR1.44808433
26MAPK111.43933579
27NEK91.43779643
28MAP2K31.37300883
29FRK1.35261495
30PIM21.30611754
31RIPK11.30575104
32PAK41.25581475
33MAP3K31.23826186
34TIE11.20694827
35TYK21.19338799
36MAP3K11.16265126
37TAOK31.15705374
38ABL21.13826235
39PINK11.11663214
40LATS11.09288793
41CDK61.06604579
42NME21.02660858
43MAP3K111.00336322
44ERBB40.99102210
45EEF2K0.97806172
46PIK3CG0.96621123
47CDK40.94223699
48TAOK10.92693921
49PTK20.87564917
50PRKAA10.86037310
51PTK60.84641470
52JAK20.82724508
53TGFBR20.82663028
54EIF2AK10.82470863
55TBK10.82111979
56ILK0.80969673
57WEE10.80657680
58PRKD20.78064808
59CDC42BPA0.77778044
60MET0.75916321
61BMX0.74421291
62JAK10.74371262
63BLK0.73864061
64SCYL20.73431917
65GRK60.72680581
66MAP3K130.70705411
67PDPK10.70651581
68MAP2K10.68547815
69NEK10.68545189
70MAPK40.65374581
71LMTK20.64135584
72IRAK40.61714841
73RPS6KA20.61592258
74PRKG20.59415136
75CSF1R0.59331621
76MTOR0.58554745
77PRKACG0.58518067
78MYLK0.57758461
79FGFR30.57533882
80MAP2K20.56934680
81STK38L0.56829418
82MAP4K10.56283520
83KSR20.55972519
84FGFR20.54597986
85ZAP700.54303473
86DAPK30.53308202
87EPHB10.53217829
88GSK3A0.52927246
89CSK0.51969528
90BUB10.51554910
91RPS6KC10.51352762
92RPS6KL10.51352762
93LATS20.50564505
94MAP3K100.50523407
95MATK0.48490370
96PDK10.48056848
97BRSK20.46360434
98ACVR1B0.45583265
99MAP3K20.45513562
100BRAF0.45174614
101MAP3K60.42874870
102LRRK20.42073846
103MOS0.41454737
104STK30.41331988
105JAK30.41257053
106FES0.40939889
107MAP3K140.40935639
108MAP2K40.40037742
109MAP3K80.39290055
110CDK90.38967536
111PDGFRA0.38696646
112TAOK20.38355821
113IKBKB0.37351740
114MAPK120.37299470
115MAPKAPK20.36690264
116MAP3K70.35784369
117HIPK20.35493463
118PRKD10.34835316
119IRAK20.34741688
120GRK50.34522779
121AKT30.33875194
122MAP2K60.33740724
123TNK20.33718332
124IGF1R0.33341666
125EIF2AK30.33046761
126STK160.32643325
127KIT0.31852157
128MAP3K50.31367609
129ICK0.31249524
130PRKCZ0.30449137
131EIF2AK20.29419891
132TTK0.28351723
133EPHA30.28231890
134MAPKAPK30.27520515
135NLK0.25875765
136TTN0.25666762
137IRAK10.25236963
138DYRK1B0.25099139
139TESK20.24553496
140NEK20.24501713

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.57265430
2Fatty acid degradation_Homo sapiens_hsa000713.05949394
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.00352917
4Propanoate metabolism_Homo sapiens_hsa006402.95477681
5Nitrogen metabolism_Homo sapiens_hsa009102.88667612
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.83900610
7PPAR signaling pathway_Homo sapiens_hsa033202.69997713
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.67028206
9Fatty acid metabolism_Homo sapiens_hsa012122.59773821
10Arginine biosynthesis_Homo sapiens_hsa002202.46346229
11Other glycan degradation_Homo sapiens_hsa005112.40436340
12Tryptophan metabolism_Homo sapiens_hsa003802.38562590
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34682036
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33272212
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.30201107
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.26964035
17Peroxisome_Homo sapiens_hsa041462.13879440
18Complement and coagulation cascades_Homo sapiens_hsa046102.13804943
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02854172
20Butanoate metabolism_Homo sapiens_hsa006502.01665606
21beta-Alanine metabolism_Homo sapiens_hsa004101.97323400
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.91655198
23Pyruvate metabolism_Homo sapiens_hsa006201.86167622
24Caffeine metabolism_Homo sapiens_hsa002321.84212440
25Fatty acid biosynthesis_Homo sapiens_hsa000611.80104792
26Carbon metabolism_Homo sapiens_hsa012001.73363819
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73320757
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72788026
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.62357211
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61826082
31Histidine metabolism_Homo sapiens_hsa003401.56025752
32Fatty acid elongation_Homo sapiens_hsa000621.55181773
33Chemical carcinogenesis_Homo sapiens_hsa052041.55107406
34Staphylococcus aureus infection_Homo sapiens_hsa051501.52477855
35* Fat digestion and absorption_Homo sapiens_hsa049751.49760470
36Vitamin B6 metabolism_Homo sapiens_hsa007501.46613615
37Phenylalanine metabolism_Homo sapiens_hsa003601.44620044
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40172253
39Retinol metabolism_Homo sapiens_hsa008301.38303288
40Folate biosynthesis_Homo sapiens_hsa007901.37228143
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.36996067
42Biosynthesis of amino acids_Homo sapiens_hsa012301.34717523
43Selenocompound metabolism_Homo sapiens_hsa004501.34615594
44Tyrosine metabolism_Homo sapiens_hsa003501.30598084
45Starch and sucrose metabolism_Homo sapiens_hsa005001.25179438
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24117965
47* Glycerolipid metabolism_Homo sapiens_hsa005611.21868437
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.19651943
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17101980
50Mineral absorption_Homo sapiens_hsa049781.16821804
51Pentose phosphate pathway_Homo sapiens_hsa000301.14375045
52Sulfur metabolism_Homo sapiens_hsa009201.14093194
53Sulfur relay system_Homo sapiens_hsa041221.10240170
54Bile secretion_Homo sapiens_hsa049761.06986586
55ABC transporters_Homo sapiens_hsa020101.02105895
56Vitamin digestion and absorption_Homo sapiens_hsa049770.96033004
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92134041
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90568156
59Glutathione metabolism_Homo sapiens_hsa004800.85783844
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84762871
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80283392
62Arginine and proline metabolism_Homo sapiens_hsa003300.79049907
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.76856613
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72538758
65Pertussis_Homo sapiens_hsa051330.71285084
66Lysine degradation_Homo sapiens_hsa003100.70949056
67Fructose and mannose metabolism_Homo sapiens_hsa000510.68434644
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.67690569
69Leishmaniasis_Homo sapiens_hsa051400.64895879
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62816055
71Steroid biosynthesis_Homo sapiens_hsa001000.61742529
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.61537382
73One carbon pool by folate_Homo sapiens_hsa006700.59746193
74Galactose metabolism_Homo sapiens_hsa000520.56711154
75* Metabolic pathways_Homo sapiens_hsa011000.55573838
76AMPK signaling pathway_Homo sapiens_hsa041520.50581231
77Osteoclast differentiation_Homo sapiens_hsa043800.49826340
78Insulin resistance_Homo sapiens_hsa049310.48894818
79Asthma_Homo sapiens_hsa053100.48879198
80* Glycerophospholipid metabolism_Homo sapiens_hsa005640.41394365
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41233123
82Sphingolipid metabolism_Homo sapiens_hsa006000.40207654
83Toxoplasmosis_Homo sapiens_hsa051450.39637327
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38821623
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.38412326
86Amoebiasis_Homo sapiens_hsa051460.36463013
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36292840
88Malaria_Homo sapiens_hsa051440.33207502
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31686830
90Allograft rejection_Homo sapiens_hsa053300.31092035
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30440141
92Salmonella infection_Homo sapiens_hsa051320.28132429
93Linoleic acid metabolism_Homo sapiens_hsa005910.26906628
94Tuberculosis_Homo sapiens_hsa051520.26833718
95Glucagon signaling pathway_Homo sapiens_hsa049220.25220751
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.24952361
97Autoimmune thyroid disease_Homo sapiens_hsa053200.24759308
98Insulin signaling pathway_Homo sapiens_hsa049100.23972667
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23753165
100Phagosome_Homo sapiens_hsa041450.22363052
101TNF signaling pathway_Homo sapiens_hsa046680.21859943
102Bladder cancer_Homo sapiens_hsa052190.21272442
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.20869060
104Notch signaling pathway_Homo sapiens_hsa043300.20749096
105Renin-angiotensin system_Homo sapiens_hsa046140.19713768
106Ovarian steroidogenesis_Homo sapiens_hsa049130.18634835
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17522036
108Graft-versus-host disease_Homo sapiens_hsa053320.17162287
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16971846
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16891021
111Prion diseases_Homo sapiens_hsa050200.10230808
112Arachidonic acid metabolism_Homo sapiens_hsa005900.09401670
113Regulation of autophagy_Homo sapiens_hsa041400.05815822
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.03405949
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02217279
116Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1986645
117Acute myeloid leukemia_Homo sapiens_hsa05221-0.1884379
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1862520
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1558629
120Legionellosis_Homo sapiens_hsa05134-0.1427564
121Hepatitis C_Homo sapiens_hsa05160-0.1393845
122Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1194963
123Lysosome_Homo sapiens_hsa04142-0.1189264
124Protein digestion and absorption_Homo sapiens_hsa04974-0.0989485
125Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0676530
126Proteasome_Homo sapiens_hsa03050-0.0388372
127Pyrimidine metabolism_Homo sapiens_hsa00240-0.0188354
128Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0173378

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