AGPAT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)3.94743152
2regulation of rhodopsin mediated signaling pathway (GO:0022400)3.91407834
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.89217116
4L-phenylalanine catabolic process (GO:0006559)3.89217116
5rhodopsin mediated signaling pathway (GO:0016056)3.85738889
6lysine metabolic process (GO:0006553)3.81708712
7lysine catabolic process (GO:0006554)3.81708712
8negative regulation of erythrocyte differentiation (GO:0045647)3.74987703
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.71849483
10L-phenylalanine metabolic process (GO:0006558)3.71849483
11protein localization to endosome (GO:0036010)3.70247236
12dicarboxylic acid biosynthetic process (GO:0043650)3.49919256
13retinal cone cell development (GO:0046549)3.49613021
14sodium ion export (GO:0071436)3.38901480
15synaptic vesicle maturation (GO:0016188)3.35606673
16aspartate family amino acid catabolic process (GO:0009068)3.35307677
17glutamate metabolic process (GO:0006536)3.28846766
18mannose metabolic process (GO:0006013)3.27677093
19aromatic amino acid family catabolic process (GO:0009074)3.26519580
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.26242642
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25441420
22cellular ketone body metabolic process (GO:0046950)3.24267697
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.23582908
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.22295525
25glyoxylate metabolic process (GO:0046487)3.16774890
26cellular potassium ion homeostasis (GO:0030007)3.14445645
27cysteine metabolic process (GO:0006534)3.09958322
28kynurenine metabolic process (GO:0070189)3.07271694
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05925207
30short-chain fatty acid metabolic process (GO:0046459)3.04023434
31locomotory exploration behavior (GO:0035641)3.02886234
32negative regulation of fatty acid transport (GO:2000192)3.00254129
33bile acid biosynthetic process (GO:0006699)2.99816587
34cytoskeletal anchoring at plasma membrane (GO:0007016)2.99684882
35carnitine shuttle (GO:0006853)2.99430953
362-oxoglutarate metabolic process (GO:0006103)2.97643167
37regulation of early endosome to late endosome transport (GO:2000641)2.97244886
38positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97016437
39fatty acid transmembrane transport (GO:1902001)2.96872868
40regulation of cholesterol homeostasis (GO:2000188)2.92883870
41phototransduction (GO:0007602)2.92608139
42amino-acid betaine metabolic process (GO:0006577)2.92329966
43positive regulation of fatty acid beta-oxidation (GO:0032000)2.89783528
44sulfur amino acid catabolic process (GO:0000098)2.87729217
45phototransduction, visible light (GO:0007603)2.87138016
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.85454123
47photoreceptor cell development (GO:0042461)2.84278986
48urea cycle (GO:0000050)2.84061476
49urea metabolic process (GO:0019627)2.84061476
50detection of light stimulus involved in sensory perception (GO:0050962)2.82042948
51detection of light stimulus involved in visual perception (GO:0050908)2.82042948
52ketone body metabolic process (GO:1902224)2.81350139
53dicarboxylic acid catabolic process (GO:0043649)2.81172381
54cellular modified amino acid catabolic process (GO:0042219)2.80973073
55fatty acid beta-oxidation (GO:0006635)2.79220517
56acetyl-CoA metabolic process (GO:0006084)2.78326044
57detection of light stimulus (GO:0009583)2.77349329
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77252455
59regulation of triglyceride catabolic process (GO:0010896)2.77146658
60amino-acid betaine transport (GO:0015838)2.77049980
61carnitine transport (GO:0015879)2.77049980
62regulation of ARF protein signal transduction (GO:0032012)2.73274876
63antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.73229426
64glutamate secretion (GO:0014047)2.73056111
65detection of visible light (GO:0009584)2.72536875
66cell communication by electrical coupling (GO:0010644)2.72322888
67tryptophan catabolic process (GO:0006569)2.72110074
68indole-containing compound catabolic process (GO:0042436)2.72110074
69indolalkylamine catabolic process (GO:0046218)2.72110074
70regulation of fatty acid beta-oxidation (GO:0031998)2.72028337
71potassium ion import (GO:0010107)2.69803339
72regulation of glucose import in response to insulin stimulus (GO:2001273)2.69761424
73high-density lipoprotein particle remodeling (GO:0034375)2.69739007
74gamma-aminobutyric acid transport (GO:0015812)2.65884229
75positive regulation of extracellular matrix organization (GO:1903055)2.65866225
76positive regulation of fatty acid oxidation (GO:0046321)2.65490538
77eye photoreceptor cell development (GO:0042462)2.64650805
78fatty acid oxidation (GO:0019395)2.63404666
79carnitine transmembrane transport (GO:1902603)2.63227491
80positive regulation of guanylate cyclase activity (GO:0031284)2.63163548
81alpha-amino acid catabolic process (GO:1901606)2.62549122
82NADH metabolic process (GO:0006734)2.62458373
83modulation by symbiont of host cellular process (GO:0044068)2.62227563
84lipid oxidation (GO:0034440)2.60957573
85positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.60017395
86phosphate ion transport (GO:0006817)2.59948592
87barbed-end actin filament capping (GO:0051016)2.59580193
88nitrogen cycle metabolic process (GO:0071941)2.58238802
89regulation of fatty acid oxidation (GO:0046320)2.58115690
90photoreceptor cell maintenance (GO:0045494)2.57833757
91fatty acid catabolic process (GO:0009062)2.57463443
92drug catabolic process (GO:0042737)2.57392860
93serine family amino acid catabolic process (GO:0009071)2.56993402
94cellular amino acid catabolic process (GO:0009063)2.56611688
95synaptic vesicle docking involved in exocytosis (GO:0016081)2.55964807
96adhesion of symbiont to host (GO:0044406)2.55628337
97positive regulation of lipid catabolic process (GO:0050996)2.55241050
98cell-substrate adherens junction assembly (GO:0007045)2.54798655
99focal adhesion assembly (GO:0048041)2.54798655
100regulation of clathrin-mediated endocytosis (GO:2000369)2.54417585
101monocarboxylic acid catabolic process (GO:0072329)2.54326355
102bile acid metabolic process (GO:0008206)2.53546395
103homocysteine metabolic process (GO:0050667)2.53294457
104stress fiber assembly (GO:0043149)2.52174950
105cellular sodium ion homeostasis (GO:0006883)2.51135321
106reverse cholesterol transport (GO:0043691)2.51123048
107positive regulation of receptor recycling (GO:0001921)2.51084296
108antigen processing and presentation of endogenous antigen (GO:0019883)2.50671783
109alanine transport (GO:0032328)2.50607200
110quaternary ammonium group transport (GO:0015697)2.50091570
111carnitine metabolic process (GO:0009437)2.49477927
112tryptophan metabolic process (GO:0006568)2.49386446
113regulation of extracellular matrix disassembly (GO:0010715)2.48771461
114acylglycerol homeostasis (GO:0055090)2.48688112
115triglyceride homeostasis (GO:0070328)2.48688112
116neurotransmitter secretion (GO:0007269)2.48000263
117regulation of guanylate cyclase activity (GO:0031282)2.46613116
118adherens junction assembly (GO:0034333)2.46259268
119complement activation, alternative pathway (GO:0006957)2.46044264
120drug transmembrane transport (GO:0006855)2.44494551
121protein-chromophore linkage (GO:0018298)2.44454106
122retinal rod cell development (GO:0046548)2.43866043
123response to mercury ion (GO:0046689)2.43276403
124response to laminar fluid shear stress (GO:0034616)2.37207956
125positive regulation of protein dephosphorylation (GO:0035307)2.36944873
126virion attachment to host cell (GO:0019062)2.35752118
127adhesion of symbiont to host cell (GO:0044650)2.35752118
128negative regulation of cell size (GO:0045792)2.34439406
129positive regulation of gamma-delta T cell activation (GO:0046645)2.33208337
130germinal center formation (GO:0002467)2.32854676
131epithelial cell differentiation involved in prostate gland development (GO:0060742)2.32714892
132negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.32455010
133cell-substrate junction assembly (GO:0007044)2.32323638
134positive regulation of Cdc42 GTPase activity (GO:0043089)2.28877042
135positive regulation of cellular amide metabolic process (GO:0034250)2.27608741
136cellular response to thyroid hormone stimulus (GO:0097067)2.25935521
137negative regulation of lipid transport (GO:0032369)2.24432925
138activation of MAPKKK activity (GO:0000185)2.22341268
139modulation by virus of host process (GO:0019054)2.22233984
140negative regulation of cell killing (GO:0031342)2.19827754
141negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.19827754
142COPI coating of Golgi vesicle (GO:0048205)2.19167169
143Golgi transport vesicle coating (GO:0048200)2.19167169
144regulation of extracellular matrix organization (GO:1903053)2.18731746
145positive regulation by organism of defense response of other organism involved in symbiotic interact2.18494203
146modulation by symbiont of host immune response (GO:0052553)2.18494203
147positive regulation by symbiont of host defense response (GO:0052509)2.18494203
148modulation by symbiont of host defense response (GO:0052031)2.18494203
149modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.18494203
150modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.18494203
151creatine metabolic process (GO:0006600)2.18315331
152hypotonic response (GO:0006971)2.18091675
153cell volume homeostasis (GO:0006884)2.16654825
154insulin-like growth factor receptor signaling pathway (GO:0048009)2.16138662
155macrophage activation involved in immune response (GO:0002281)2.15818651
156response to thyroid hormone (GO:0097066)2.15398800
157retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.14134711
158protein-lipid complex assembly (GO:0065005)2.13285685
159positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.13284629
160modulation by virus of host morphology or physiology (GO:0019048)2.10546462
161low-density lipoprotein particle clearance (GO:0034383)2.09559562
162positive regulation of Rap GTPase activity (GO:0032854)2.09248721
163fructose metabolic process (GO:0006000)2.09235944
164regulation of type I interferon-mediated signaling pathway (GO:0060338)2.09021925
165positive regulation of triglyceride lipase activity (GO:0061365)2.08492850
166positive regulation of lipoprotein lipase activity (GO:0051006)2.08492850
167detection of bacterium (GO:0016045)2.08250338
168detection of other organism (GO:0098543)2.07215437
169signal complex assembly (GO:0007172)2.06916260
170pinocytosis (GO:0006907)2.05630724
171activation of Rac GTPase activity (GO:0032863)2.05226848
172negative regulation of viral release from host cell (GO:1902187)2.03856602
173regulation of cholesterol biosynthetic process (GO:0045540)2.03536128
174response to type I interferon (GO:0034340)2.02629195
175glycosphingolipid catabolic process (GO:0046479)2.02389497
176regulation of membrane protein ectodomain proteolysis (GO:0051043)2.02304532
177positive regulation of myotube differentiation (GO:0010831)2.02217970
178lipopolysaccharide-mediated signaling pathway (GO:0031663)2.02211625
179positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.01881281
180skeletal muscle adaptation (GO:0043501)2.01729176
181regulation of cholesterol storage (GO:0010885)2.01526114
182thymic T cell selection (GO:0045061)2.00172265
183protein carboxylation (GO:0018214)2.00007069
184peptidyl-glutamic acid carboxylation (GO:0017187)2.00007069
185positive regulation of macrophage cytokine production (GO:0060907)1.99350008
186cellular response to type I interferon (GO:0071357)1.99174585
187type I interferon signaling pathway (GO:0060337)1.99174585
188response to muramyl dipeptide (GO:0032495)1.98137299
189negative regulation of fibrinolysis (GO:0051918)1.97700780
190response to peptidoglycan (GO:0032494)1.97621831
191negative regulation of fatty acid biosynthetic process (GO:0045717)1.97523538
192cortical actin cytoskeleton organization (GO:0030866)1.96441666

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.53739395
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.38283960
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.86564734
4LXR_22158963_ChIP-Seq_LIVER_Mouse2.86246692
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.80910285
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.80486075
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52900135
8EZH2_22144423_ChIP-Seq_EOC_Human2.42855375
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.35803568
10* VDR_21846776_ChIP-Seq_THP-1_Human2.34644776
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.21326653
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12474946
13DROSHA_22980978_ChIP-Seq_HELA_Human2.11183861
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.10391608
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09443913
16RACK7_27058665_Chip-Seq_MCF-7_Human2.06147532
17TCF7_22412390_ChIP-Seq_EML_Mouse2.03506298
18MYC_22102868_ChIP-Seq_BL_Human2.03202080
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81312129
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78174323
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74879858
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.74072351
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68570758
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.67106345
25VDR_24763502_ChIP-Seq_THP-1_Human1.66698354
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63265727
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62971320
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61659537
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61038089
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61038089
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58407080
32GATA1_19941827_ChIP-Seq_MEL_Mouse1.53749279
33REST_21632747_ChIP-Seq_MESCs_Mouse1.52768990
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.52405108
35* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52244667
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51266576
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50990500
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49125431
39* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48866465
40GATA1_19941826_ChIP-Seq_K562_Human1.47840853
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46679880
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44711572
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.43246479
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43003530
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41041174
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.40088979
47* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39970241
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.39363039
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39278180
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37888088
51* FOXA2_19822575_ChIP-Seq_HepG2_Human1.35811854
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35401492
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34696467
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34645937
55MAF_26560356_Chip-Seq_TH1_Human1.34317393
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34191031
57GBX2_23144817_ChIP-Seq_PC3_Human1.33034233
58* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32424239
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32145136
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31870614
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31796119
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31165535
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31073809
64KDM2B_26808549_Chip-Seq_K562_Human1.30501085
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30495678
66SPI1_23127762_ChIP-Seq_K562_Human1.30100251
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28990626
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27998200
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27417091
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27259339
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26353587
72P68_20966046_ChIP-Seq_HELA_Human1.26343608
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.26198960
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25064394
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24904940
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.23570250
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23421836
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.23328444
79EGR1_19374776_ChIP-ChIP_THP-1_Human1.20554002
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.20053904
81* LXR_22292898_ChIP-Seq_THP-1_Human1.19936056
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16674567
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.16647245
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.15867712
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.15790548
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15403977
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.14971492
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14728830
89AR_21572438_ChIP-Seq_LNCaP_Human1.14206549
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.14173578
91STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12762850
92TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11752809
93GATA1_22025678_ChIP-Seq_K562_Human1.11478299
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10960628
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10481394
96IRF8_27001747_Chip-Seq_BMDM_Mouse1.09578055
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.08985348
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08202931
99* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08097106
100SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08074436
101CTCF_27219007_Chip-Seq_Bcells_Human1.08007794
102ZNF263_19887448_ChIP-Seq_K562_Human1.07833839
103* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06741533
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06119268
105SCL_19346495_ChIP-Seq_HPC-7_Human1.05944446
106EZH2_27304074_Chip-Seq_ESCs_Mouse1.05119631
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04940207
108MAF_26560356_Chip-Seq_TH2_Human1.04131987
109SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04118563
110P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03742093
111GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02697887
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02358183
113SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02192131
114* BCOR_27268052_Chip-Seq_Bcells_Human1.01093268
115TBX20_22328084_ChIP-Seq_HEART_Mouse1.00060111
116TBX20_22080862_ChIP-Seq_HEART_Mouse1.00060111
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99682457
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.99446337
119TP53_22127205_ChIP-Seq_IMR90_Human0.99050266
120EED_16625203_ChIP-ChIP_MESCs_Mouse0.97683041
121IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97502199
122SMC4_20622854_ChIP-Seq_HELA_Human0.97218566
123* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97168828
124* AR_19668381_ChIP-Seq_PC3_Human0.97112022
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94176139
126* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93981961
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93971103
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92705596
129CLOCK_20551151_ChIP-Seq_293T_Human0.92447627
130* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91651660
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89654102
132RING1B_27294783_Chip-Seq_ESCs_Mouse0.89619670
133* SMAD3_21741376_ChIP-Seq_HESCs_Human0.89538615
134RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88337672
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87903359
136SOX2_21211035_ChIP-Seq_LN229_Gbm0.87732572
137SMAD4_21799915_ChIP-Seq_A2780_Human0.86968718
138AHR_22903824_ChIP-Seq_MCF-7_Human0.86910001
139BCAT_22108803_ChIP-Seq_LS180_Human0.86562962
140KLF4_19829295_ChIP-Seq_ESCs_Human0.86547112
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85398077
142ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84585585
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83613469
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83200969
145ARNT_22903824_ChIP-Seq_MCF-7_Human0.82776715
146* CREB1_26743006_Chip-Seq_LNCaP_Human0.81813798
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81146627
148TET1_21490601_ChIP-Seq_MESCs_Mouse0.80994864
149* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79452614
150CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.78726028
151* HNF4A_19822575_ChIP-Seq_HepG2_Human0.77376327
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76963759
153PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76493180
154* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76462943
155KDM2B_26808549_Chip-Seq_DND41_Human0.75599011
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74457802
157PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.74433918
158* KDM2B_26808549_Chip-Seq_JURKAT_Human0.74265143
159* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.73281668
160RARG_19884340_ChIP-ChIP_MEFs_Mouse0.71774285
161MYC_27129775_Chip-Seq_CORNEA_Mouse0.71622107
162TP63_22573176_ChIP-Seq_HFKS_Human0.71375715
163ZNF274_21170338_ChIP-Seq_K562_Hela0.71183536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.39035183
2MP0002139_abnormal_hepatobiliary_system4.36412431
3MP0005360_urolithiasis4.30093035
4MP0005551_abnormal_eye_electrophysiolog3.91111550
5MP0005451_abnormal_body_composition3.67271005
6MP0005365_abnormal_bile_salt3.20864484
7MP0005085_abnormal_gallbladder_physiolo3.13547772
8MP0004859_abnormal_synaptic_plasticity2.97528368
9MP0003303_peritoneal_inflammation2.73921993
10MP0005058_abnormal_lysosome_morphology2.72008660
11MP0008875_abnormal_xenobiotic_pharmacok2.63052940
12MP0003252_abnormal_bile_duct2.44469719
13MP0003300_gastrointestinal_ulcer2.37725418
14MP0005253_abnormal_eye_physiology2.35136398
15MP0010329_abnormal_lipoprotein_level2.22122797
16MP0003436_decreased_susceptibility_to2.11812066
17MP0005409_darkened_coat_color2.10617699
18MP0006072_abnormal_retinal_apoptosis2.09781601
19MP0003172_abnormal_lysosome_physiology2.03389198
20MP0005332_abnormal_amino_acid1.96605865
21MP0004510_myositis1.96422104
22MP0004019_abnormal_vitamin_homeostasis1.90972423
23MP0004270_analgesia1.89676425
24MP0004130_abnormal_muscle_cell1.87681566
25MP0003329_amyloid_beta_deposits1.85657835
26MP0002837_dystrophic_cardiac_calcinosis1.82210403
27MP0003635_abnormal_synaptic_transmissio1.81850232
28MP0004043_abnormal_pH_regulation1.81771992
29MP0002877_abnormal_melanocyte_morpholog1.81071047
30MP0002090_abnormal_vision1.78379670
31MP0004947_skin_inflammation1.74922045
32MP0002822_catalepsy1.74701017
33MP0003195_calcinosis1.72976505
34MP0003091_abnormal_cell_migration1.72714464
35MP0009780_abnormal_chondrocyte_physiolo1.67834659
36MP0003566_abnormal_cell_adhesion1.64570976
37MP0005423_abnormal_somatic_nervous1.63258112
38MP0010234_abnormal_vibrissa_follicle1.62951721
39MP0000685_abnormal_immune_system1.62720994
40MP0003879_abnormal_hair_cell1.61077169
41MP0003183_abnormal_peptide_metabolism1.60515219
42MP0005076_abnormal_cell_differentiation1.58470632
43MP0008438_abnormal_cutaneous_collagen1.58251346
44MP0009840_abnormal_foam_cell1.57771864
45MP0002118_abnormal_lipid_homeostasis1.55849426
46MP0004885_abnormal_endolymph1.54999240
47MP0003453_abnormal_keratinocyte_physiol1.52726348
48MP0002229_neurodegeneration1.50760284
49MP0008260_abnormal_autophagy1.50323213
50MP0001958_emphysema1.48732157
51MP0002909_abnormal_adrenal_gland1.48708631
52MP0005670_abnormal_white_adipose1.47871695
53MP0000751_myopathy1.45707046
54MP0003045_fibrosis1.44126205
55MP0002064_seizures1.41774119
56MP0005195_abnormal_posterior_eye1.40721932
57MP0009046_muscle_twitch1.38959262
58MP0005083_abnormal_biliary_tract1.37978955
59MP0008961_abnormal_basal_metabolism1.37142320
60MP0009745_abnormal_behavioral_response1.36909652
61MP0003279_aneurysm1.36261193
62MP0002063_abnormal_learning/memory/cond1.35852453
63MP0003646_muscle_fatigue1.35028112
64MP0001790_abnormal_immune_system1.34462292
65MP0005387_immune_system_phenotype1.34462292
66MP0010155_abnormal_intestine_physiology1.31804549
67MP0001348_abnormal_lacrimal_gland1.29315644
68MP0001486_abnormal_startle_reflex1.29096646
69MP0005584_abnormal_enzyme/coenzyme_acti1.28603594
70MP0001849_ear_inflammation1.27129960
71MP0003690_abnormal_glial_cell1.26413947
72MP0005025_abnormal_response_to1.26131065
73MP0001666_abnormal_nutrient_absorption1.24785524
74MP0005535_abnormal_body_temperature1.24400481
75MP0005666_abnormal_adipose_tissue1.24286505
76MP0003191_abnormal_cellular_cholesterol1.23935645
77MP0000604_amyloidosis1.23609370
78MP0002998_abnormal_bone_remodeling1.23219785
79MP0001835_abnormal_antigen_presentation1.23202453
80MP0005166_decreased_susceptibility_to1.23030994
81MP0001324_abnormal_eye_pigmentation1.22704037
82MP0002419_abnormal_innate_immunity1.20294292
83MP0001764_abnormal_homeostasis1.17540971
84MP0004233_abnormal_muscle_weight1.16302016
85MP0002272_abnormal_nervous_system1.15327933
86MP0003950_abnormal_plasma_membrane1.15287004
87MP0000920_abnormal_myelination1.14230357
88MP0001533_abnormal_skeleton_physiology1.14013431
89MP0005000_abnormal_immune_tolerance1.13783046
90MP0003880_abnormal_central_pattern1.12722204
91MP0005464_abnormal_platelet_physiology1.10563564
92MP0000858_altered_metastatic_potential1.09084048
93MP0009278_abnormal_bone_marrow1.08862582
94MP0003633_abnormal_nervous_system1.08288598
95MP0000609_abnormal_liver_physiology1.07739723
96MP0008569_lethality_at_weaning1.07111480
97MP0002971_abnormal_brown_adipose1.06883363
98MP0004215_abnormal_myocardial_fiber1.06631784
99MP0003763_abnormal_thymus_physiology1.05707564
100MP0003705_abnormal_hypodermis_morpholog1.05433245
101MP0005023_abnormal_wound_healing1.04352377
102MP0003806_abnormal_nucleotide_metabolis1.03680364
103MP0009785_altered_susceptibility_to1.02927883
104MP0004858_abnormal_nervous_system1.02890341
105MP0006082_CNS_inflammation1.02782203
106MP0002572_abnormal_emotion/affect_behav1.01576116
107MP0002734_abnormal_mechanical_nocicepti1.00580140
108MP0005319_abnormal_enzyme/_coenzyme1.00135927
109MP0000678_abnormal_parathyroid_gland0.99501364
110MP0001984_abnormal_olfaction0.97992770
111MP0003656_abnormal_erythrocyte_physiolo0.97426242
112MP0000013_abnormal_adipose_tissue0.95219887
113MP0001873_stomach_inflammation0.94917081
114MP0005310_abnormal_salivary_gland0.94546787
115MP0004381_abnormal_hair_follicle0.93977259
116MP0000747_muscle_weakness0.93760249
117MP0005330_cardiomyopathy0.93451062
118MP0002078_abnormal_glucose_homeostasis0.93426770
119MP0005410_abnormal_fertilization0.92951173
120MP0000733_abnormal_muscle_development0.92565816
121MP0005391_vision/eye_phenotype0.92405920
122MP0004036_abnormal_muscle_relaxation0.92010439
123MP0000759_abnormal_skeletal_muscle0.91171841
124MP0002882_abnormal_neuron_morphology0.90318750
125MP0001765_abnormal_ion_homeostasis0.90124428
126MP0001800_abnormal_humoral_immune0.89930925
127MP0001502_abnormal_circadian_rhythm0.89515876
128MP0009643_abnormal_urine_homeostasis0.89079739
129MP0005375_adipose_tissue_phenotype0.89005286
130MP0003075_altered_response_to0.88717445
131MP0002166_altered_tumor_susceptibility0.88214312
132MP0001968_abnormal_touch/_nociception0.88094377
133MP0000003_abnormal_adipose_tissue0.88026696
134MP0005623_abnormal_meninges_morphology0.87089160
135MP0002896_abnormal_bone_mineralization0.85967942
136MP0002148_abnormal_hypersensitivity_rea0.83804758
137MP0002332_abnormal_exercise_endurance0.83494187
138MP0002067_abnormal_sensory_capabilities0.83336992
139MP0009333_abnormal_splenocyte_physiolog0.82953137
140MP0002723_abnormal_immune_serum0.82898738
141MP0002796_impaired_skin_barrier0.82876666
142MP0003634_abnormal_glial_cell0.82699914
143MP0003828_pulmonary_edema0.82545869
144MP0001501_abnormal_sleep_pattern0.81496044
145MP0002452_abnormal_antigen_presenting0.81321225
146MP0001440_abnormal_grooming_behavior0.81081599
147MP0004087_abnormal_muscle_fiber0.79690596
148MP0009115_abnormal_fat_cell0.79452720
149MP0002269_muscular_atrophy0.79269233
150MP0003631_nervous_system_phenotype0.79223867
151MP0005620_abnormal_muscle_contractility0.79043649
152MP0002089_abnormal_postnatal_growth/wei0.78440232
153MP0003868_abnormal_feces_composition0.78130283
154MP0005386_behavior/neurological_phenoty0.77490783
155MP0004924_abnormal_behavior0.77490783
156MP0003866_abnormal_defecation0.77244031
157MP0001845_abnormal_inflammatory_respons0.76618000
158MP0004145_abnormal_muscle_electrophysio0.76548115
159MP0005165_increased_susceptibility_to0.76537403
160MP0000343_altered_response_to0.76377821
161MP0004185_abnormal_adipocyte_glucose0.76084001
162MP0002138_abnormal_hepatobiliary_system0.75307294
163MP0004085_abnormal_heartbeat0.74766270
164MP0006138_congestive_heart_failure0.74335958
165MP0003724_increased_susceptibility_to0.73934598
166MP0005167_abnormal_blood-brain_barrier0.73925238
167MP0008469_abnormal_protein_level0.73496794
168MP0002752_abnormal_somatic_nervous0.73340093
169MP0008874_decreased_physiological_sensi0.73238448
170MP0001756_abnormal_urination0.72914224
171MP0004084_abnormal_cardiac_muscle0.72764256

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.91414827
2Bony spicule pigmentary retinopathy (HP:0007737)5.15250311
3Central scotoma (HP:0000603)5.13824555
4Pigmentary retinal degeneration (HP:0001146)4.89155580
5Chorioretinal atrophy (HP:0000533)4.43606230
6Scotoma (HP:0000575)4.14883840
7Abnormal rod and cone electroretinograms (HP:0008323)4.09232066
8Abnormality of macular pigmentation (HP:0008002)4.04670768
9Absent rod-and cone-mediated responses on ERG (HP:0007688)4.00632756
10Dyschromatopsia (HP:0007641)3.99959686
11Deep venous thrombosis (HP:0002625)3.51645125
12Abolished electroretinogram (ERG) (HP:0000550)3.37683038
13Ketosis (HP:0001946)3.33413998
14Xanthomatosis (HP:0000991)3.28883983
15Ketoacidosis (HP:0001993)3.17719991
16Abnormality of aromatic amino acid family metabolism (HP:0004338)3.17219051
17Obstructive sleep apnea (HP:0002870)3.11075160
18Hyperglycinuria (HP:0003108)3.03363317
19Intrahepatic cholestasis (HP:0001406)3.01305586
20Decreased central vision (HP:0007663)2.96011653
21Hyperammonemia (HP:0001987)2.89506256
22Gout (HP:0001997)2.85658320
23Hyperlipoproteinemia (HP:0010980)2.84657763
24Abnormality of serine family amino acid metabolism (HP:0010894)2.84134752
25Abnormality of glycine metabolism (HP:0010895)2.84134752
26Attenuation of retinal blood vessels (HP:0007843)2.77137721
27Macular degeneration (HP:0000608)2.74818088
28Myokymia (HP:0002411)2.74088393
29Pendular nystagmus (HP:0012043)2.71749245
30Posterior subcapsular cataract (HP:0007787)2.71640896
31Type II diabetes mellitus (HP:0005978)2.68899278
32Protrusio acetabuli (HP:0003179)2.67755083
33Hypoglycemic coma (HP:0001325)2.65924063
34Distal lower limb muscle weakness (HP:0009053)2.63651091
35Dysostosis multiplex (HP:0000943)2.61434066
36Systemic lupus erythematosus (HP:0002725)2.60893357
37Asymmetric septal hypertrophy (HP:0001670)2.60885839
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.56591815
39Hyperglycinemia (HP:0002154)2.53999498
40Myoglobinuria (HP:0002913)2.53556915
41Retinal atrophy (HP:0001105)2.50923062
42Eczematoid dermatitis (HP:0000976)2.50812330
43Complement deficiency (HP:0004431)2.50298707
44Abnormality of monocarboxylic acid metabolism (HP:0010996)2.50195293
45Cone-rod dystrophy (HP:0000548)2.49846513
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.48305323
47Hypoalphalipoproteinemia (HP:0003233)2.47873721
48Centrally nucleated skeletal muscle fibers (HP:0003687)2.46688031
49Cerebral aneurysm (HP:0004944)2.46566277
50Hyperacusis (HP:0010780)2.46391450
51Exercise-induced myalgia (HP:0003738)2.44263692
52Increased connective tissue (HP:0009025)2.43746986
53Abnormality of complement system (HP:0005339)2.41204292
54Epidermoid cyst (HP:0200040)2.40024164
55Urinary glycosaminoglycan excretion (HP:0003541)2.35726424
56Mucopolysacchariduria (HP:0008155)2.35726424
57Distal lower limb amyotrophy (HP:0008944)2.34332724
58Action tremor (HP:0002345)2.34318582
59Thin bony cortex (HP:0002753)2.31679400
60Broad face (HP:0000283)2.31197432
61Hemorrhage of the eye (HP:0011885)2.30941686
62Abnormality of fatty-acid metabolism (HP:0004359)2.30468117
63Choroideremia (HP:0001139)2.28456768
64Dysmetric saccades (HP:0000641)2.28446512
65Subcapsular cataract (HP:0000523)2.26011441
66Dysdiadochokinesis (HP:0002075)2.25742376
67Flat acetabular roof (HP:0003180)2.25094646
68Photophobia (HP:0000613)2.25020000
69Increased variability in muscle fiber diameter (HP:0003557)2.24335086
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24303546
71Abnormality of polysaccharide metabolism (HP:0011012)2.24303546
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24303546
73Abnormality of the lower motor neuron (HP:0002366)2.22220924
74Type 1 muscle fiber predominance (HP:0003803)2.21415086
75Visual hallucinations (HP:0002367)2.19729072
76Vitreoretinal degeneration (HP:0000655)2.18517931
77Vertebral compression fractures (HP:0002953)2.18355177
78Abnormality of glycolipid metabolism (HP:0010969)2.18306385
79Abnormality of liposaccharide metabolism (HP:0010968)2.18306385
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.18306385
81Hypobetalipoproteinemia (HP:0003563)2.17732203
82Hypolipoproteinemia (HP:0010981)2.17283502
83Achilles tendon contracture (HP:0001771)2.14252614
84Status epilepticus (HP:0002133)2.13262276
85Intention tremor (HP:0002080)2.11509644
86Abnormality of skeletal muscle fiber size (HP:0012084)2.08653597
87Polycythemia (HP:0001901)2.05760684
88Neurofibrillary tangles (HP:0002185)2.04688717
89Increased cerebral lipofuscin (HP:0011813)2.04060932
90Postural instability (HP:0002172)2.03262830
91Emphysema (HP:0002097)2.02294943
92Aneurysm (HP:0002617)2.01925934
93Supranuclear gaze palsy (HP:0000605)2.01791738
94Ventricular fibrillation (HP:0001663)2.01741693
95Increased circulating renin level (HP:0000848)2.01133884
96Distal upper limb amyotrophy (HP:0007149)2.01072935
97Upper limb amyotrophy (HP:0009129)2.01072935
98Malnutrition (HP:0004395)2.00474534
99Bundle branch block (HP:0011710)2.00071126
100Increased IgE level (HP:0003212)1.98127055
101Gastrointestinal stroma tumor (HP:0100723)1.96960152
102Prolonged partial thromboplastin time (HP:0003645)1.96652356
103Retinitis pigmentosa (HP:0000510)1.96215815
104Hyperparathyroidism (HP:0000843)1.96191002
105Sensorimotor neuropathy (HP:0007141)1.96180702
106Abnormality of purine metabolism (HP:0004352)1.96065219
107Mildly elevated creatine phosphokinase (HP:0008180)1.95373283
108Cerebral inclusion bodies (HP:0100314)1.95077181
109Delayed CNS myelination (HP:0002188)1.94399522
110Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93352077
111Glomerulonephritis (HP:0000099)1.92139637
112Abnormality of the common coagulation pathway (HP:0010990)1.91193360
113Abnormal gallbladder physiology (HP:0012438)1.90913193
114Cholecystitis (HP:0001082)1.90913193
115Increased purine levels (HP:0004368)1.88608320
116Hyperuricemia (HP:0002149)1.88608320
117Neonatal onset (HP:0003623)1.88400960
118Hypercortisolism (HP:0001578)1.88338904
119Focal motor seizures (HP:0011153)1.88147555
120Cellulitis (HP:0100658)1.87346964
121Hypokalemic alkalosis (HP:0001949)1.86004134
122Interstitial pulmonary disease (HP:0006530)1.84303167
123Impaired social interactions (HP:0000735)1.83842533
124Abnormal social behavior (HP:0012433)1.83842533
125Pheochromocytoma (HP:0002666)1.83774623
126Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83683249
127Loss of speech (HP:0002371)1.83595223
128Focal seizures (HP:0007359)1.83529557
129Premature rupture of membranes (HP:0001788)1.82395449
130Colitis (HP:0002583)1.81986079
131Neuronal loss in central nervous system (HP:0002529)1.81756987
132Progressive visual loss (HP:0000529)1.81560386
133Abnormality of macrophages (HP:0004311)1.81130542
134Stridor (HP:0010307)1.81114143
135Constricted visual fields (HP:0001133)1.80770679
136Hyporeflexia of lower limbs (HP:0002600)1.80689470
137Sudden death (HP:0001699)1.79756355
138Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77363154
139Abnormality of sulfur amino acid metabolism (HP:0004339)1.76725486
140Myopathic facies (HP:0002058)1.75754613
141Amyloidosis (HP:0011034)1.75619146
142Progressive cerebellar ataxia (HP:0002073)1.75196795
143Myocardial infarction (HP:0001658)1.74959761
144Arterial tortuosity (HP:0005116)1.74847861
145Difficulty running (HP:0009046)1.74633956
146Gingivitis (HP:0000230)1.74439006
147Osteolytic defects of the hand bones (HP:0009699)1.74200404
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.74200404
149Abnormality of the fingertips (HP:0001211)1.74046083
150Depression (HP:0000716)1.73646906
151Torticollis (HP:0000473)1.73643744
152Metabolic alkalosis (HP:0200114)1.73114970
153Purpura (HP:0000979)1.72962327
154Axonal loss (HP:0003447)1.72692499
155Hyperinsulinemic hypoglycemia (HP:0000825)1.72495778
156Abnormality of the nasal mucosa (HP:0000433)1.72469714
157Vascular tortuosity (HP:0004948)1.72279580
158Syncope (HP:0001279)1.71966123
159Prolonged QT interval (HP:0001657)1.71505048
160Mitral regurgitation (HP:0001653)1.71467235
161J-shaped sella turcica (HP:0002680)1.71452056
162Hemiplegia (HP:0002301)1.71109689
163Exercise-induced muscle cramps (HP:0003710)1.71018451
164Hyperventilation (HP:0002883)1.70401903
165Abnormality of the Achilles tendon (HP:0005109)1.70083542
166Foot dorsiflexor weakness (HP:0009027)1.70079299
167Polygenic inheritance (HP:0010982)1.68813718
168Cervical subluxation (HP:0003308)1.68706771
169Lower limb amyotrophy (HP:0007210)1.67813997
170Ankle clonus (HP:0011448)1.66323681
171Increased neuronal autofluorescent lipopigment (HP:0002074)1.66190222
172Segmental peripheral demyelination/remyelination (HP:0003481)1.65239849
173Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.63298638
174Onion bulb formation (HP:0003383)1.62731082
175Recurrent gram-negative bacterial infections (HP:0005420)1.61586997
176Ulnar bowing (HP:0003031)1.61586938
177Insomnia (HP:0100785)1.61160986
178Spinal rigidity (HP:0003306)1.60711108
179Aortic aneurysm (HP:0004942)1.60586963
180Mitral stenosis (HP:0001718)1.60145434
181Bone pain (HP:0002653)1.59789499
182Abnormality of the thoracic spine (HP:0100711)1.58608487
183Fragile skin (HP:0001030)1.57357418
184Dilatation of the ascending aorta (HP:0005111)1.57191691
185Nephritis (HP:0000123)1.55340682
186Slow saccadic eye movements (HP:0000514)1.55273376
187Disproportionate tall stature (HP:0001519)1.55038536
188Muscle fiber splitting (HP:0003555)1.52833835

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.69427542
2TRIB32.82156655
3PRKD32.51709656
4EEF2K2.42484126
5RIPK42.35172308
6PDK42.32106313
7PDK32.32106313
8EPHA42.24823616
9IRAK32.23018224
10SMG12.18853120
11PINK12.17518193
12MAP3K132.02785109
13PAK62.00455322
14MAP3K91.98895023
15GRK11.96913843
16BCKDK1.94938110
17STK381.92010740
18WNK41.90758500
19LMTK21.89855337
20RIPK11.86653884
21NTRK31.85493015
22PHKG11.80766728
23PHKG21.80766728
24SIK11.78017778
25DAPK21.72880795
26CAMKK11.72126448
27MAP3K41.68551126
28CAMK1G1.62039307
29MAP2K41.60935496
30MARK11.60652474
31MAP2K31.55323659
32CDK121.53665983
33PKN21.51525982
34ICK1.48298226
35KSR21.46987324
36TYK21.40897183
37MINK11.38981457
38PDK21.38941370
39MAP3K31.38882254
40PRKCH1.32971881
41NTRK21.24832974
42MAP3K71.24632405
43MAP4K11.24187152
44NTRK11.24165166
45TAOK21.23363815
46MAP3K141.22280357
47SGK2231.21465166
48SGK4941.21465166
49FGFR41.20809821
50SGK31.17641413
51ERN11.17186079
52FGFR31.17132653
53CAMK1D1.15140121
54NEK11.14863335
55WNK11.14303122
56STK391.14008111
57OXSR11.13354413
58DDR21.10870831
59TBK11.10260028
60MAP3K21.09204283
61MAPKAPK31.08529155
62TYRO31.07715883
63INSRR1.06650596
64SIK21.05711917
65PRKD21.02890314
66PDPK11.01513313
67MAPK111.01363482
68RET1.01337815
69PDK11.00211981
70PAK30.97144135
71WNK30.96884234
72ARAF0.95802277
73FGFR20.94618015
74MAP3K110.93865196
75CDK50.93580279
76BLK0.92523104
77MAPK120.91765935
78NEK90.90040491
79SGK20.87771036
80MTOR0.87241404
81STK110.85983817
82PTK60.85350329
83TAOK10.85318182
84ZAP700.85236015
85EPHA20.84245282
86RPS6KA20.82771516
87TRPM70.78673769
88PRKAA10.77956315
89PDGFRA0.77366021
90PRKCZ0.76284813
91IRAK20.75814422
92PRKCG0.74083472
93JAK30.73987373
94TTN0.73570132
95TNK20.71906652
96MST1R0.71562519
97MARK20.68477093
98DMPK0.68313671
99HIPK20.67067670
100CAMK10.66138005
101CSK0.65268020
102PRKD10.65019348
103PRKACG0.61472864
104IRAK40.61045871
105MAP3K100.60491116
106LRRK20.60274836
107PRKAA20.60118126
108LATS20.60105152
109SCYL20.59237234
110SGK10.57386262
111NME20.56184268
112JAK10.55694631
113ERBB20.55650312
114RPS6KA30.55127616
115RPS6KC10.54824038
116RPS6KL10.54824038
117KSR10.53895587
118MAP3K10.53572479
119CDC42BPA0.53445954
120PTK2B0.53405704
121EPHB10.53047890
122CAMK2A0.52090237
123ALK0.51139445
124DYRK1B0.51079879
125CAMK40.50811445
126TESK10.50105870
127GRK50.49484899
128MAP2K70.49315224
129CAMK2G0.48963602
130LATS10.47396557
131CAMK2D0.47291608
132PDGFRB0.46221635
133JAK20.46192212
134MAPK40.46091027
135PTK20.45908004
136PKN10.45790901
137ROCK10.43853083
138PIM20.43820344
139PRKG20.42559263
140FER0.41929209
141CAMKK20.41558712
142MELK0.41555339
143MAP3K60.41460084
144IKBKE0.40527804
145PNCK0.40178823
146BMX0.40122867
147HCK0.39903352
148MAPK70.39870685
149CSF1R0.38683618
150GRK60.38580795
151RPS6KA60.37475445
152SYK0.37395711
153MAP2K10.36953871

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.38408000
2Nitrogen metabolism_Homo sapiens_hsa009104.09519485
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.74266856
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.35019954
5Arginine biosynthesis_Homo sapiens_hsa002202.26609784
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.26132189
7Fatty acid degradation_Homo sapiens_hsa000712.23732284
8Other glycan degradation_Homo sapiens_hsa005112.12240822
9Propanoate metabolism_Homo sapiens_hsa006402.04665401
10Butanoate metabolism_Homo sapiens_hsa006502.01428881
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.97019344
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93435728
13Fatty acid metabolism_Homo sapiens_hsa012121.91867390
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.88488915
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85500915
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74898980
17PPAR signaling pathway_Homo sapiens_hsa033201.72053919
18Bile secretion_Homo sapiens_hsa049761.66862503
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65753149
20Tryptophan metabolism_Homo sapiens_hsa003801.56555313
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56241406
22B cell receptor signaling pathway_Homo sapiens_hsa046621.47358279
23Acute myeloid leukemia_Homo sapiens_hsa052211.44365111
24Prion diseases_Homo sapiens_hsa050201.41722068
25Pyruvate metabolism_Homo sapiens_hsa006201.41073859
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41035932
27VEGF signaling pathway_Homo sapiens_hsa043701.39641542
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.36042000
29Osteoclast differentiation_Homo sapiens_hsa043801.35176191
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32163280
31Synaptic vesicle cycle_Homo sapiens_hsa047211.30711561
32Chronic myeloid leukemia_Homo sapiens_hsa052201.30105019
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29675453
34Non-small cell lung cancer_Homo sapiens_hsa052231.23393650
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21646938
36Fatty acid biosynthesis_Homo sapiens_hsa000611.21504002
37GnRH signaling pathway_Homo sapiens_hsa049121.20554555
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19346616
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.19003037
40Peroxisome_Homo sapiens_hsa041461.18622117
41GABAergic synapse_Homo sapiens_hsa047271.16774116
42Carbon metabolism_Homo sapiens_hsa012001.14592597
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11719103
44Olfactory transduction_Homo sapiens_hsa047401.11607852
45Hepatitis C_Homo sapiens_hsa051601.11223920
46Leishmaniasis_Homo sapiens_hsa051401.10880070
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09778330
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09185161
49beta-Alanine metabolism_Homo sapiens_hsa004101.06737163
50Complement and coagulation cascades_Homo sapiens_hsa046101.05063846
51Glioma_Homo sapiens_hsa052141.04662889
52mTOR signaling pathway_Homo sapiens_hsa041501.03283678
53Pancreatic cancer_Homo sapiens_hsa052121.02565125
54Lysosome_Homo sapiens_hsa041421.00386305
55Renal cell carcinoma_Homo sapiens_hsa052110.99827613
56Toxoplasmosis_Homo sapiens_hsa051450.99439952
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98052177
58TNF signaling pathway_Homo sapiens_hsa046680.95881656
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95792664
60ABC transporters_Homo sapiens_hsa020100.93792044
61Insulin secretion_Homo sapiens_hsa049110.92675850
62Circadian entrainment_Homo sapiens_hsa047130.92295127
63Prolactin signaling pathway_Homo sapiens_hsa049170.92006714
64Estrogen signaling pathway_Homo sapiens_hsa049150.91219370
65Gastric acid secretion_Homo sapiens_hsa049710.90427140
66Endometrial cancer_Homo sapiens_hsa052130.90323148
67Tuberculosis_Homo sapiens_hsa051520.90263858
68Glutamatergic synapse_Homo sapiens_hsa047240.90112971
69Fatty acid elongation_Homo sapiens_hsa000620.90027166
70Influenza A_Homo sapiens_hsa051640.89825824
71Biosynthesis of amino acids_Homo sapiens_hsa012300.88679151
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87980048
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87883620
74Amoebiasis_Homo sapiens_hsa051460.87574487
75Bladder cancer_Homo sapiens_hsa052190.87331900
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86431467
77ErbB signaling pathway_Homo sapiens_hsa040120.86055651
78* Phospholipase D signaling pathway_Homo sapiens_hsa040720.84724695
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84286163
80Salivary secretion_Homo sapiens_hsa049700.82133491
81Retinol metabolism_Homo sapiens_hsa008300.80981117
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.79855445
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79509866
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78465667
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78112755
86Glucagon signaling pathway_Homo sapiens_hsa049220.77574873
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77299201
88Fat digestion and absorption_Homo sapiens_hsa049750.77210423
89Choline metabolism in cancer_Homo sapiens_hsa052310.77136049
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.77090991
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76250740
92Starch and sucrose metabolism_Homo sapiens_hsa005000.76089025
93Morphine addiction_Homo sapiens_hsa050320.75485470
94* Glycerolipid metabolism_Homo sapiens_hsa005610.75438102
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.75252233
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75077750
97Focal adhesion_Homo sapiens_hsa045100.74494300
98Lysine degradation_Homo sapiens_hsa003100.73581603
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73568624
100Caffeine metabolism_Homo sapiens_hsa002320.73307981
101Phenylalanine metabolism_Homo sapiens_hsa003600.73271371
102Pertussis_Homo sapiens_hsa051330.72049973
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71080907
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70924846
105Notch signaling pathway_Homo sapiens_hsa043300.70916596
106Nicotine addiction_Homo sapiens_hsa050330.70708683
107Galactose metabolism_Homo sapiens_hsa000520.70417858
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.69740381
109Inositol phosphate metabolism_Homo sapiens_hsa005620.69492739
110Cholinergic synapse_Homo sapiens_hsa047250.69368000
111Sulfur metabolism_Homo sapiens_hsa009200.69265854
112Long-term potentiation_Homo sapiens_hsa047200.69191687
113Hepatitis B_Homo sapiens_hsa051610.67908253
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.67567015
115T cell receptor signaling pathway_Homo sapiens_hsa046600.66931673
116Dopaminergic synapse_Homo sapiens_hsa047280.66455203
117Pentose phosphate pathway_Homo sapiens_hsa000300.66360898
118Renin secretion_Homo sapiens_hsa049240.66348507
119Chemical carcinogenesis_Homo sapiens_hsa052040.65941163
120Chemokine signaling pathway_Homo sapiens_hsa040620.65820643
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64629581
122Type II diabetes mellitus_Homo sapiens_hsa049300.63464216
123Platelet activation_Homo sapiens_hsa046110.62259789
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.62150996
125Amphetamine addiction_Homo sapiens_hsa050310.61277107
126Endocytosis_Homo sapiens_hsa041440.60115464
127Insulin resistance_Homo sapiens_hsa049310.59347042
128Proteoglycans in cancer_Homo sapiens_hsa052050.59214418
129Histidine metabolism_Homo sapiens_hsa003400.58591757
130Cardiac muscle contraction_Homo sapiens_hsa042600.56636827
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56614695
132Measles_Homo sapiens_hsa051620.56433269
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56193133
134HIF-1 signaling pathway_Homo sapiens_hsa040660.55955510
135Viral myocarditis_Homo sapiens_hsa054160.55847804
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55240183
137Allograft rejection_Homo sapiens_hsa053300.55025242
138Prostate cancer_Homo sapiens_hsa052150.53913750
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.53164910
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.53114405
141Tyrosine metabolism_Homo sapiens_hsa003500.53007877
142Apoptosis_Homo sapiens_hsa042100.52586972
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51659213
144cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51273182
145cAMP signaling pathway_Homo sapiens_hsa040240.50777349
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.50625808
147Oxytocin signaling pathway_Homo sapiens_hsa049210.50153373
148AMPK signaling pathway_Homo sapiens_hsa041520.49355826
149Thyroid hormone synthesis_Homo sapiens_hsa049180.49250631
150Cocaine addiction_Homo sapiens_hsa050300.48901027
151Dilated cardiomyopathy_Homo sapiens_hsa054140.48053983
152Renin-angiotensin system_Homo sapiens_hsa046140.47577133
153Malaria_Homo sapiens_hsa051440.47275752
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41484313
155Insulin signaling pathway_Homo sapiens_hsa049100.40943115
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40135293
157Calcium signaling pathway_Homo sapiens_hsa040200.40079927
158Selenocompound metabolism_Homo sapiens_hsa004500.38594643
159Drug metabolism - other enzymes_Homo sapiens_hsa009830.37139687
160Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35792631
161Arginine and proline metabolism_Homo sapiens_hsa003300.35703469
162Maturity onset diabetes of the young_Homo sapiens_hsa049500.35195727
163Staphylococcus aureus infection_Homo sapiens_hsa051500.35032040
164Pancreatic secretion_Homo sapiens_hsa049720.34546423
165Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34213053
166Fructose and mannose metabolism_Homo sapiens_hsa000510.33827694
167* Glycerophospholipid metabolism_Homo sapiens_hsa005640.33547600

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