AGPAT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)6.95866157
2long-chain fatty acid biosynthetic process (GO:0042759)6.43382528
3ensheathment of neurons (GO:0007272)5.96734473
4axon ensheathment (GO:0008366)5.96734473
5myelination (GO:0042552)5.95880853
6pyrimidine nucleobase catabolic process (GO:0006208)5.83273038
7postsynaptic membrane organization (GO:0001941)5.31607352
8negative regulation of neurotransmitter transport (GO:0051589)5.09813518
9negative regulation of neurotransmitter secretion (GO:0046929)4.69326435
10regulation of collateral sprouting (GO:0048670)4.49724179
11nucleobase catabolic process (GO:0046113)4.40375667
12synaptic vesicle maturation (GO:0016188)4.35086032
13myelin maintenance (GO:0043217)4.28230233
14cholesterol biosynthetic process (GO:0006695)4.25763189
15establishment of mitochondrion localization (GO:0051654)4.23572261
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.10994933
17vocalization behavior (GO:0071625)4.09759528
18cell migration in hindbrain (GO:0021535)4.08825522
19oligodendrocyte differentiation (GO:0048709)4.04300615
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.99943376
21locomotory exploration behavior (GO:0035641)3.99789501
22central nervous system projection neuron axonogenesis (GO:0021952)3.97699163
23negative regulation of protein localization to cell surface (GO:2000009)3.96919945
24regulation of synaptic vesicle exocytosis (GO:2000300)3.94733168
25eye photoreceptor cell differentiation (GO:0001754)3.92790381
26photoreceptor cell differentiation (GO:0046530)3.92790381
27presynaptic membrane organization (GO:0097090)3.90742946
28neuron cell-cell adhesion (GO:0007158)3.90686985
29response to methylmercury (GO:0051597)3.88710234
30glycerophospholipid catabolic process (GO:0046475)3.85701783
31neurotransmitter-gated ion channel clustering (GO:0072578)3.83157824
32apical protein localization (GO:0045176)3.80922160
33sterol biosynthetic process (GO:0016126)3.73724731
34protein localization to synapse (GO:0035418)3.73389489
35layer formation in cerebral cortex (GO:0021819)3.73198905
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.72896364
37amyloid precursor protein metabolic process (GO:0042982)3.71814350
38dendrite morphogenesis (GO:0048813)3.66114303
39presynaptic membrane assembly (GO:0097105)3.65845673
40synaptic transmission, glutamatergic (GO:0035249)3.62139369
41establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.61131946
42mitochondrion transport along microtubule (GO:0047497)3.61131946
43L-amino acid import (GO:0043092)3.60453445
44isoprenoid biosynthetic process (GO:0008299)3.60120350
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59369133
46response to redox state (GO:0051775)3.55117742
47astrocyte development (GO:0014002)3.54392364
48substantia nigra development (GO:0021762)3.54279868
49positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.52071409
50positive regulation of oligodendrocyte differentiation (GO:0048714)3.50568257
51exploration behavior (GO:0035640)3.50120944
52peptidyl-tyrosine autophosphorylation (GO:0038083)3.49438037
53synaptic vesicle docking involved in exocytosis (GO:0016081)3.45795312
54asymmetric protein localization (GO:0008105)3.43121470
55auditory behavior (GO:0031223)3.41458505
56negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.41294803
57dopamine biosynthetic process (GO:0042416)3.38668045
58long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.37384971
59response to auditory stimulus (GO:0010996)3.31137074
60neuron remodeling (GO:0016322)3.30656979
61regulation of synaptic vesicle transport (GO:1902803)3.29803176
62axon extension (GO:0048675)3.29454028
63glutamate secretion (GO:0014047)3.29195053
64establishment of nucleus localization (GO:0040023)3.28572527
65long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.25516783
66glutamate receptor signaling pathway (GO:0007215)3.21556394
67positive regulation of synapse assembly (GO:0051965)3.20376302
68cerebral cortex radially oriented cell migration (GO:0021799)3.18489592
69synapse assembly (GO:0007416)3.18173035
70neuronal stem cell maintenance (GO:0097150)3.16861420
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16332491
72limb bud formation (GO:0060174)3.15724609
73spinal cord development (GO:0021510)3.15439819
74negative regulation of axonogenesis (GO:0050771)3.14226972
75adult walking behavior (GO:0007628)3.13719794
76regulation of synapse structural plasticity (GO:0051823)3.13097126
77dendrite development (GO:0016358)3.11113256
78myelination in peripheral nervous system (GO:0022011)3.10875697
79peripheral nervous system axon ensheathment (GO:0032292)3.10875697
80neuron-neuron synaptic transmission (GO:0007270)3.09038556
81central nervous system neuron axonogenesis (GO:0021955)3.08168100
82regulation of glutamate receptor signaling pathway (GO:1900449)3.07764397
83protein palmitoylation (GO:0018345)3.06564115
84import into cell (GO:0098657)3.05736905
85regulation of growth hormone secretion (GO:0060123)3.04283994
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03693897
87cerebellar granule cell differentiation (GO:0021707)3.03432544
88regulation of dopamine metabolic process (GO:0042053)3.02943331
89regulation of catecholamine metabolic process (GO:0042069)3.02943331
90creatine metabolic process (GO:0006600)3.02109109
91axon extension involved in axon guidance (GO:0048846)3.01358145
92neuron projection extension involved in neuron projection guidance (GO:1902284)3.01358145
93response to lipoprotein particle (GO:0055094)3.00659166
94spinal cord association neuron differentiation (GO:0021527)3.00337784
95positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.97781287
96adhesion of symbiont to host cell (GO:0044650)2.97351271
97virion attachment to host cell (GO:0019062)2.97351271
98neuromuscular process controlling balance (GO:0050885)2.94193577
99retinal ganglion cell axon guidance (GO:0031290)2.90753349
100synaptic vesicle endocytosis (GO:0048488)2.89289811
101glycosylceramide metabolic process (GO:0006677)2.86954741
102regulation of neuronal synaptic plasticity (GO:0048168)2.86883664
103magnesium ion transport (GO:0015693)2.85065596
104olfactory bulb development (GO:0021772)2.84480456
105cerebellar Purkinje cell differentiation (GO:0021702)2.84262752
106neuron projection extension (GO:1990138)2.82814078
107camera-type eye morphogenesis (GO:0048593)2.81731644
108cerebral cortex neuron differentiation (GO:0021895)2.81254778
109negative regulation of axon extension (GO:0030517)2.80734239
110startle response (GO:0001964)2.79996618
111neurotransmitter uptake (GO:0001504)2.79959733
112neuron recognition (GO:0008038)2.78105380
113axonogenesis (GO:0007409)2.77909928
114mechanosensory behavior (GO:0007638)2.77149307
115protein neddylation (GO:0045116)2.76959799
116positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75778467
117regulation of neurotransmitter secretion (GO:0046928)2.75524001
118cellular response to epinephrine stimulus (GO:0071872)2.74924275
119transmission of nerve impulse (GO:0019226)2.74564801
120amino acid import (GO:0043090)2.74276216
121limb development (GO:0060173)2.74137378
122appendage development (GO:0048736)2.74137378
123forebrain neuron differentiation (GO:0021879)2.73806334
124positive regulation of dendritic spine morphogenesis (GO:0061003)2.72374519
125membrane assembly (GO:0071709)2.71419478
126neuromuscular synaptic transmission (GO:0007274)2.71333449
127neuron projection morphogenesis (GO:0048812)2.70750587
128regulation of excitatory postsynaptic membrane potential (GO:0060079)2.69871813
129positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69551218
130GPI anchor biosynthetic process (GO:0006506)2.69479329
131positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.69055722
132enteric nervous system development (GO:0048484)2.68851359
133synapse organization (GO:0050808)2.68648222
134peptidyl-cysteine modification (GO:0018198)2.68579525
135peripheral nervous system development (GO:0007422)2.67499900
136regulation of synaptic transmission, glutamatergic (GO:0051966)2.66505729
137positive regulation of growth hormone secretion (GO:0060124)2.66501302
138detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.66399477
139detection of temperature stimulus involved in sensory perception (GO:0050961)2.66399477
140axon development (GO:0061564)2.66084661
141fatty-acyl-CoA metabolic process (GO:0035337)2.64770430
142regulation of axon guidance (GO:1902667)2.64520755
143fatty-acyl-CoA biosynthetic process (GO:0046949)2.64127230
144suckling behavior (GO:0001967)2.64028030
145positive regulation of action potential (GO:0045760)2.63889556
146membrane tubulation (GO:0097320)2.63800817
147GPI anchor metabolic process (GO:0006505)2.63149026
148ganglion development (GO:0061548)2.63036207
149cellular potassium ion homeostasis (GO:0030007)2.62886394
150negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.59296213
151neural nucleus development (GO:0048857)2.54310080
152glial cell development (GO:0021782)2.53938148
153negative regulation of execution phase of apoptosis (GO:1900118)2.53343018
154response to epinephrine (GO:0071871)2.53164499
155neuronal action potential propagation (GO:0019227)2.50096397
156axonal fasciculation (GO:0007413)2.49930127
157negative regulation of synaptic transmission (GO:0050805)2.49681052
158positive regulation of actin filament depolymerization (GO:0030836)2.48927577
159neuronal ion channel clustering (GO:0045161)2.45959896
160substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.45171303
161substrate-independent telencephalic tangential migration (GO:0021826)2.45171303
162ceramide biosynthetic process (GO:0046513)2.42302819
163cellular response to monoamine stimulus (GO:0071868)2.40759453
164cellular response to catecholamine stimulus (GO:0071870)2.40759453
165negative regulation of acute inflammatory response (GO:0002674)2.40387237
166regulation of lipoprotein metabolic process (GO:0050746)2.39674187
167nucleotide transmembrane transport (GO:1901679)2.38117249
168negative regulation of synaptic transmission, GABAergic (GO:0032229)2.37843989
169mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.37413270
170microtubule polymerization or depolymerization (GO:0031109)2.37236088
171glial cell differentiation (GO:0010001)2.36615497
172positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.35765308
173amyloid precursor protein catabolic process (GO:0042987)2.34762143
174dendritic spine morphogenesis (GO:0060997)2.34650852
175gamma-aminobutyric acid signaling pathway (GO:0007214)2.33722184
176synaptic vesicle exocytosis (GO:0016079)2.33422605
177central nervous system myelination (GO:0022010)10.1506298
178axon ensheathment in central nervous system (GO:0032291)10.1506298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.48786135
2EZH2_22144423_ChIP-Seq_EOC_Human3.15195059
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.68867511
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.68177211
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67103017
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60977000
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54288599
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.36142324
9* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.30731767
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27891623
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.25907985
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25546080
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25546080
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21761387
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21700633
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20487130
17TAF15_26573619_Chip-Seq_HEK293_Human2.19256694
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11136184
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11126708
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09759511
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07643134
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04308928
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03545709
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.02024790
25AR_21572438_ChIP-Seq_LNCaP_Human1.93856016
26VDR_22108803_ChIP-Seq_LS180_Human1.92497724
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88365188
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.84450642
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83717203
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.80894732
31* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.78730664
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.72854337
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71552822
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70249958
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69484060
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64867166
37DROSHA_22980978_ChIP-Seq_HELA_Human1.63326509
38ER_23166858_ChIP-Seq_MCF-7_Human1.60823587
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59138429
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59138429
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58533499
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57144716
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56468793
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54947457
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52827047
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.51235256
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50116779
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49597501
49OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.48432747
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47894875
51P300_19829295_ChIP-Seq_ESCs_Human1.41262912
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39206777
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.38083936
54REST_21632747_ChIP-Seq_MESCs_Mouse1.36066858
55* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.33833184
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32819065
57* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31943966
58RNF2_27304074_Chip-Seq_NSC_Mouse1.31421083
59FUS_26573619_Chip-Seq_HEK293_Human1.30417190
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29768775
61* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29132148
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26583662
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.24119727
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23471907
65* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22156130
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20046304
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.19609885
68* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19562738
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19542614
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.17097097
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16882747
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16742301
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.15240173
74SMAD4_21799915_ChIP-Seq_A2780_Human1.15167569
75IGF1R_20145208_ChIP-Seq_DFB_Human1.14156425
76AR_19668381_ChIP-Seq_PC3_Human1.13467948
77SOX9_26525672_Chip-Seq_HEART_Mouse1.13097504
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12923021
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.11084317
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.10592499
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09633434
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08900667
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08628295
84* KDM2B_26808549_Chip-Seq_K562_Human1.07697215
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07165959
86SMAD3_21741376_ChIP-Seq_ESCs_Human1.06933129
87STAT3_23295773_ChIP-Seq_U87_Human1.05622418
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05477731
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03437324
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03437324
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03373054
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.02665704
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.02489643
94* TP53_20018659_ChIP-ChIP_R1E_Mouse1.01993010
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01729597
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.01685025
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.00734882
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00550049
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.00144894
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99988015
101TP53_18474530_ChIP-ChIP_U2OS_Human0.99135738
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98974999
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98153117
104TRIM28_21343339_ChIP-Seq_HEK293_Human0.97712678
105RING1B_27294783_Chip-Seq_NPCs_Mouse0.97363038
106TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96993966
107POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96408571
108* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95938328
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.95786068
110EP300_21415370_ChIP-Seq_HL-1_Mouse0.95594312
111TCF4_23295773_ChIP-Seq_U87_Human0.95293761
112* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94734218
113SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94463997
114* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94402510
115GATA1_26923725_Chip-Seq_HPCs_Mouse0.94216232
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93980128
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93665740
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93403856
119IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93263290
120SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93202566
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.92771307
122NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92056702
123ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91989917
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91446001
125* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91309403
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91242355
127RUNX2_22187159_ChIP-Seq_PCA_Human0.90366864
128LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90228734
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.90174212
130AHR_22903824_ChIP-Seq_MCF-7_Human0.88112320
131P300_18555785_Chip-Seq_ESCs_Mouse0.87138980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.42095229
2MP0003880_abnormal_central_pattern4.23752535
3MP0004270_analgesia3.23419920
4MP0001529_abnormal_vocalization3.18576043
5MP0003950_abnormal_plasma_membrane2.95128883
6MP0001905_abnormal_dopamine_level2.84890580
7MP0005171_absent_coat_pigmentation2.62523023
8MP0004859_abnormal_synaptic_plasticity2.61894816
9MP0004742_abnormal_vestibular_system2.58034241
10MP0002272_abnormal_nervous_system2.57149001
11MP0003787_abnormal_imprinting2.41066337
12MP0002064_seizures2.39637217
13MP0001486_abnormal_startle_reflex2.32276961
14MP0003690_abnormal_glial_cell2.30957152
15MP0000778_abnormal_nervous_system2.28070476
16MP0003329_amyloid_beta_deposits2.27924059
17MP0005423_abnormal_somatic_nervous2.23213946
18MP0004885_abnormal_endolymph2.14429155
19MP0003635_abnormal_synaptic_transmissio2.10566306
20MP0002653_abnormal_ependyma_morphology2.10108442
21MP0009046_muscle_twitch2.08085195
22MP0003634_abnormal_glial_cell2.06974330
23MP0002734_abnormal_mechanical_nocicepti2.06678954
24MP0009745_abnormal_behavioral_response2.04228789
25MP0003136_yellow_coat_color2.03957205
26MP0004142_abnormal_muscle_tone2.02024137
27MP0006292_abnormal_olfactory_placode1.96063800
28MP0005409_darkened_coat_color1.92376840
29MP0003121_genomic_imprinting1.86188962
30MP0002822_catalepsy1.77002332
31MP0002572_abnormal_emotion/affect_behav1.76373191
32MP0001970_abnormal_pain_threshold1.74636926
33MP0001485_abnormal_pinna_reflex1.72804805
34MP0001440_abnormal_grooming_behavior1.70847062
35MP0005499_abnormal_olfactory_system1.70287633
36MP0005394_taste/olfaction_phenotype1.70287633
37MP0002063_abnormal_learning/memory/cond1.67522471
38MP0002733_abnormal_thermal_nociception1.66023213
39MP0001968_abnormal_touch/_nociception1.65707901
40MP0000569_abnormal_digit_pigmentation1.63414736
41MP0002735_abnormal_chemical_nociception1.61454971
42MP0003632_abnormal_nervous_system1.55725748
43MP0002229_neurodegeneration1.53822080
44MP0002736_abnormal_nociception_after1.52258568
45MP0010678_abnormal_skin_adnexa1.47757921
46MP0005410_abnormal_fertilization1.45361438
47MP0000955_abnormal_spinal_cord1.44601237
48MP0003123_paternal_imprinting1.44136119
49MP0003861_abnormal_nervous_system1.42848686
50MP0006276_abnormal_autonomic_nervous1.40670221
51MP0002882_abnormal_neuron_morphology1.39937594
52MP0002067_abnormal_sensory_capabilities1.37293752
53MP0004381_abnormal_hair_follicle1.36648772
54MP0000462_abnormal_digestive_system1.36103297
55MP0000383_abnormal_hair_follicle1.35411713
56MP0004134_abnormal_chest_morphology1.35122429
57MP0005386_behavior/neurological_phenoty1.31546084
58MP0004924_abnormal_behavior1.31546084
59MP0005623_abnormal_meninges_morphology1.30142142
60MP0008789_abnormal_olfactory_epithelium1.29237847
61MP0003631_nervous_system_phenotype1.29068780
62MP0002066_abnormal_motor_capabilities/c1.23793013
63MP0001963_abnormal_hearing_physiology1.23064421
64MP0005645_abnormal_hypothalamus_physiol1.22327514
65MP0005551_abnormal_eye_electrophysiolog1.22091599
66MP0001293_anophthalmia1.22045523
67MP0001501_abnormal_sleep_pattern1.21518697
68MP0002184_abnormal_innervation1.18968492
69MP0000049_abnormal_middle_ear1.18541892
70MP0001346_abnormal_lacrimal_gland1.17044745
71MP0000566_synostosis1.16317407
72MP0002752_abnormal_somatic_nervous1.16017040
73MP0008569_lethality_at_weaning1.14687131
74MP0008260_abnormal_autophagy1.13614774
75MP0000604_amyloidosis1.13505736
76MP0003890_abnormal_embryonic-extraembry1.10669734
77MP0002233_abnormal_nose_morphology1.10486881
78MP0003633_abnormal_nervous_system1.08955088
79MP0004043_abnormal_pH_regulation1.07340535
80MP0002557_abnormal_social/conspecific_i1.05099258
81MP0005187_abnormal_penis_morphology1.04926103
82MP0005248_abnormal_Harderian_gland1.04719474
83MP0002638_abnormal_pupillary_reflex1.03906923
84MP0005646_abnormal_pituitary_gland1.02908918
85MP0003938_abnormal_ear_development1.01840802
86MP0003119_abnormal_digestive_system1.01606859
87MP0005451_abnormal_body_composition1.01493221
88MP0000762_abnormal_tongue_morphology1.01278355
89MP0003283_abnormal_digestive_organ0.99332789
90MP0000537_abnormal_urethra_morphology0.97091384
91MP0010030_abnormal_orbit_morphology0.96992253
92MP0001177_atelectasis0.94438104
93MP0000428_abnormal_craniofacial_morphol0.93726341
94MP0001299_abnormal_eye_distance/0.92202767
95MP0000026_abnormal_inner_ear0.88932134
96MP0000647_abnormal_sebaceous_gland0.87304124
97MP0002152_abnormal_brain_morphology0.86243340
98MP0005195_abnormal_posterior_eye0.84438312
99MP0009379_abnormal_foot_pigmentation0.83813450
100MP0002081_perinatal_lethality0.83782334
101MP0002697_abnormal_eye_size0.82795366
102MP0005377_hearing/vestibular/ear_phenot0.81301430
103MP0003878_abnormal_ear_physiology0.81301430
104MP0002295_abnormal_pulmonary_circulatio0.80573486
105MP0003937_abnormal_limbs/digits/tail_de0.80539058
106MP0001188_hyperpigmentation0.80341960
107MP0004811_abnormal_neuron_physiology0.79533885
108MP0001664_abnormal_digestion0.78005548
109MP0002116_abnormal_craniofacial_bone0.77665123
110MP0004858_abnormal_nervous_system0.77054723
111MP0000579_abnormal_nail_morphology0.76861241
112MP0010386_abnormal_urinary_bladder0.75555459
113MP0009250_abnormal_appendicular_skeleto0.75463731
114MP0002069_abnormal_eating/drinking_beha0.74829476
115MP0003755_abnormal_palate_morphology0.74684165
116MP0003942_abnormal_urinary_system0.74148538
117MP0000747_muscle_weakness0.72680599
118MP0003122_maternal_imprinting0.71325750
119MP0000372_irregular_coat_pigmentation0.71131039
120MP0000631_abnormal_neuroendocrine_gland0.70367476
121MP0004147_increased_porphyrin_level0.70157638
122MP0001851_eye_inflammation0.66782236
123MP0004133_heterotaxia0.65882461
124MP0002938_white_spotting0.65813756
125MP0002796_impaired_skin_barrier0.65341297
126MP0002751_abnormal_autonomic_nervous0.64822012
127MP0001340_abnormal_eyelid_morphology0.63838822
128MP0001984_abnormal_olfaction0.62739961
129MP0001502_abnormal_circadian_rhythm0.61991386
130MP0000467_abnormal_esophagus_morphology0.61861790
131MP0001348_abnormal_lacrimal_gland0.61567522

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.81146717
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.81146717
3Parakeratosis (HP:0001036)5.77947595
4Neurofibrillary tangles (HP:0002185)5.53972088
5Abnormality of the corticospinal tract (HP:0002492)4.32922168
6Sensory axonal neuropathy (HP:0003390)4.13905163
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.11242922
8Cerebral inclusion bodies (HP:0100314)4.10758571
9Peripheral hypomyelination (HP:0007182)4.01870626
10Cerebral hypomyelination (HP:0006808)3.89251718
11Hepatoblastoma (HP:0002884)3.81567652
12Supranuclear gaze palsy (HP:0000605)3.57392863
13Drooling (HP:0002307)3.45697909
14Onion bulb formation (HP:0003383)3.36290580
15Myokymia (HP:0002411)3.32820600
16Congenital ichthyosiform erythroderma (HP:0007431)3.31145659
17Limb dystonia (HP:0002451)3.26360509
18Excessive salivation (HP:0003781)3.21947165
19Cortical dysplasia (HP:0002539)3.19216984
20Alacrima (HP:0000522)3.19070172
21Spastic gait (HP:0002064)3.08857113
22Ankle clonus (HP:0011448)3.00954407
23Insidious onset (HP:0003587)2.90214046
24Termporal pattern (HP:0011008)2.90214046
25Abnormal auditory evoked potentials (HP:0006958)2.90159474
26Leukodystrophy (HP:0002415)2.90122276
27Dysmetria (HP:0001310)2.89457483
28Retinal dysplasia (HP:0007973)2.80124054
29Vitreoretinal degeneration (HP:0000655)2.78279394
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.77540925
31Akinesia (HP:0002304)2.77509613
32Polyphagia (HP:0002591)2.75677075
33Febrile seizures (HP:0002373)2.74160892
34Short 4th metacarpal (HP:0010044)2.66575726
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66575726
36Intention tremor (HP:0002080)2.62042987
37Segmental peripheral demyelination/remyelination (HP:0003481)2.61552082
38Abnormality of glycolysis (HP:0004366)2.61175055
39Increased serum pyruvate (HP:0003542)2.61175055
40Absent septum pellucidum (HP:0001331)2.53851700
41Abnormality of the 4th metacarpal (HP:0010012)2.52409787
42Decreased lacrimation (HP:0000633)2.51702332
43Hypoplastic pelvis (HP:0008839)2.47187200
44Inappropriate behavior (HP:0000719)2.45442969
45Scanning speech (HP:0002168)2.44962511
46Pheochromocytoma (HP:0002666)2.41652878
47Slow saccadic eye movements (HP:0000514)2.40991376
48Autoamputation (HP:0001218)2.38707389
49Cutaneous finger syndactyly (HP:0010554)2.37852413
50Patchy hypopigmentation of hair (HP:0011365)2.36452128
51Abnormal eating behavior (HP:0100738)2.36350613
52Hyperventilation (HP:0002883)2.35642158
53Urinary bladder sphincter dysfunction (HP:0002839)2.32863153
54Progressive cerebellar ataxia (HP:0002073)2.32333967
55Oligodactyly (hands) (HP:0001180)2.31817105
56Abnormality of the septum pellucidum (HP:0007375)2.29478255
57Focal motor seizures (HP:0011153)2.29411277
58White forelock (HP:0002211)2.25848150
59Anteriorly placed anus (HP:0001545)2.25224177
60Clumsiness (HP:0002312)2.24656763
61Cutaneous syndactyly (HP:0012725)2.24500147
62Morphological abnormality of the inner ear (HP:0011390)2.21113663
63Anomalous pulmonary venous return (HP:0010772)2.18034439
64Abnormality of the lower motor neuron (HP:0002366)2.16986979
65Stridor (HP:0010307)2.14211393
66Generalized tonic-clonic seizures (HP:0002069)2.13067041
67Abnormality of the labia minora (HP:0012880)2.10880336
68Absent/shortened dynein arms (HP:0200106)2.10668218
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.10668218
70Partial agenesis of the corpus callosum (HP:0001338)2.10362689
71Neuroendocrine neoplasm (HP:0100634)2.09797091
72Septo-optic dysplasia (HP:0100842)2.08842004
73Optic nerve hypoplasia (HP:0000609)2.08405953
74Adrenal hypoplasia (HP:0000835)2.08392345
75Hypoplasia of the iris (HP:0007676)2.08343090
76CNS hypomyelination (HP:0003429)2.07643569
77Thickened helices (HP:0000391)2.06973044
78Oligodactyly (HP:0012165)2.05737806
79Absent speech (HP:0001344)2.04221602
80Vaginal atresia (HP:0000148)2.03692057
81Spastic paraparesis (HP:0002313)2.03557600
82Turricephaly (HP:0000262)2.03520929
83Aplasia involving bones of the extremities (HP:0009825)2.01893627
84Aplasia involving bones of the upper limbs (HP:0009823)2.01893627
85Aplasia of the phalanges of the hand (HP:0009802)2.01893627
86Lower limb muscle weakness (HP:0007340)2.00614040
87Foot dorsiflexor weakness (HP:0009027)1.98683904
88Impaired vibration sensation in the lower limbs (HP:0002166)1.96910997
89Split foot (HP:0001839)1.96654855
90Genital tract atresia (HP:0001827)1.95818394
91Acute necrotizing encephalopathy (HP:0006965)1.95399559
92Myelomeningocele (HP:0002475)1.95371799
93Metabolic alkalosis (HP:0200114)1.94958931
94Disinhibition (HP:0000734)1.94450007
95Coronal craniosynostosis (HP:0004440)1.94110669
96Abnormality of the ischium (HP:0003174)1.93874872
97High anterior hairline (HP:0009890)1.93078442
98Agitation (HP:0000713)1.92778604
99Abnormality of salivation (HP:0100755)1.92373423
100Sleep apnea (HP:0010535)1.92175527
101Growth hormone deficiency (HP:0000824)1.91586258
102Increased circulating renin level (HP:0000848)1.91495820
103Aqueductal stenosis (HP:0002410)1.90829559
104Hypoplasia of the corpus callosum (HP:0002079)1.90502248
105Agnosia (HP:0010524)1.89819658
106Amyotrophic lateral sclerosis (HP:0007354)1.88929569
107Dialeptic seizures (HP:0011146)1.88686809
108Cerebral hemorrhage (HP:0001342)1.88643855
109Abnormality of the diencephalon (HP:0010662)1.87972863
110Methylmalonic acidemia (HP:0002912)1.86630892
111Abnormality of the pulmonary veins (HP:0011718)1.86582198
112Cupped ear (HP:0000378)1.86398485
113Apathy (HP:0000741)1.85972945
114Genetic anticipation (HP:0003743)1.83459356
115Mutism (HP:0002300)1.82581622
116Erythroderma (HP:0001019)1.82090280
117Decreased motor nerve conduction velocity (HP:0003431)1.81374540
118Anophthalmia (HP:0000528)1.81373200
119Premature skin wrinkling (HP:0100678)1.81182177
120Nephronophthisis (HP:0000090)1.80667972
121Colon cancer (HP:0003003)1.80417034
122Poor speech (HP:0002465)1.79725444
123Megalencephaly (HP:0001355)1.79484779
124Gait imbalance (HP:0002141)1.79456932
125Epileptic encephalopathy (HP:0200134)1.79218593
126Abnormal ciliary motility (HP:0012262)1.77992445
127Esophageal atresia (HP:0002032)1.77301213
128Renal Fanconi syndrome (HP:0001994)1.76905961
129Atonic seizures (HP:0010819)1.76764596
1303-Methylglutaconic aciduria (HP:0003535)1.75803684
131Hemiplegia (HP:0002301)1.75115154
132Focal seizures (HP:0007359)1.74511902
133Abnormality of the foot musculature (HP:0001436)1.74215851
134Action tremor (HP:0002345)1.73782206
135Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73385197
136Abnormality of binocular vision (HP:0011514)1.72843692
137Diplopia (HP:0000651)1.72843692
138Intellectual disability, moderate (HP:0002342)1.72613724
139Hemiparesis (HP:0001269)1.72435750
140Diminished motivation (HP:0000745)1.72363986
141Intestinal atresia (HP:0011100)1.72196550
142Protruding tongue (HP:0010808)1.71701742
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70684715
144Diminished movement (HP:0002374)1.70531023
145Steppage gait (HP:0003376)1.70360616
146Spastic tetraplegia (HP:0002510)1.69537524
147Stereotypic behavior (HP:0000733)1.68118213
148Conical tooth (HP:0000698)1.67973872
149Abnormality of the middle phalanges of the toes (HP:0010183)1.67507361
150Omphalocele (HP:0001539)1.66000894
151Aplasia/Hypoplasia of the sternum (HP:0006714)1.65732542
152Specific learning disability (HP:0001328)1.65415695
153Broad long bones (HP:0005622)1.64669492
154Morphological abnormality of the pyramidal tract (HP:0002062)1.64537299
155Bowel incontinence (HP:0002607)1.64459811
156Neonatal short-limb short stature (HP:0008921)1.64074449
157Broad thumb (HP:0011304)1.63880181
158Broad phalanges of the hand (HP:0009768)1.62775479
159Trigonocephaly (HP:0000243)1.62660623
160Amblyopia (HP:0000646)1.62535415
161Epileptiform EEG discharges (HP:0011182)1.61995288
162Abnormality of the phalanges of the 2nd finger (HP:0009541)1.61770620
163Distal sensory impairment (HP:0002936)1.61419154
164Urinary urgency (HP:0000012)1.61047605
165Absence seizures (HP:0002121)1.60635220
166Broad finger (HP:0001500)1.60603963
167Broad-based gait (HP:0002136)1.60348405
168Aplasia/Hypoplasia of the brainstem (HP:0007362)1.60342484
169Hypoplasia of the brainstem (HP:0002365)1.60342484
170Exotropia (HP:0000577)1.59874558
171Abnormality of the antihelix (HP:0009738)1.59787363
172Tracheomalacia (HP:0002779)1.59654033
173Hypomagnesemia (HP:0002917)1.59568206
174Paraparesis (HP:0002385)1.58490679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.37352551
2OXSR13.77646817
3MAPKAPK52.95853965
4EPHB12.80145790
5PBK2.68869007
6PKN12.54087522
7BCR2.49811663
8MET2.48800602
9CASK2.29224894
10CDK192.26471010
11EPHB22.25896982
12WNK42.18757958
13LIMK12.10439898
14UHMK11.88454225
15SIK21.88390691
16CSNK1G31.81931210
17WNK11.75409329
18PNCK1.72559796
19TNIK1.69870373
20FGR1.69401449
21PRPF4B1.66650601
22CAMK2B1.64872605
23NEK61.61385352
24NTRK11.56718002
25MARK11.53788870
26CSNK1A1L1.47859605
27MST41.47225261
28ROCK21.46183114
29FGFR21.45497844
30CAMK2D1.43086060
31CSNK1G21.35659064
32EPHA41.33891661
33SGK2231.33662063
34SGK4941.33662063
35CSNK1G11.32214088
36CAMK1D1.30385893
37SGK21.24121465
38CAMKK11.23176529
39KSR11.23156972
40DYRK21.18936904
41MAP2K41.17275447
42BMPR1B1.12839530
43PAK61.10939708
44PIK3CA1.10253509
45CLK11.06429038
46TYRO31.05183019
47DAPK21.04915480
48TESK21.04697363
49WNK31.04416327
50CAMK2A1.01754723
51MAPK131.00937044
52LATS20.98527106
53MARK20.97384599
54KSR20.97024596
55CAMK2G0.95566139
56STK110.94973758
57CDK140.93747974
58ADRBK20.93365032
59DDR20.92303039
60CAMK10.92113223
61CDK50.92098503
62MST1R0.89777321
63BRD40.89739942
64MAP3K20.88649386
65NME10.88557474
66MAP2K20.87914436
67ICK0.87381535
68SGK30.86373198
69MKNK20.84931104
70NTRK20.84236814
71CDK150.82991473
72MAPK150.82114963
73CDK180.80432020
74PRKCE0.80383045
75DYRK1B0.78986418
76NTRK30.78115149
77ARAF0.76479099
78CAMK40.76030797
79MOS0.75479455
80CDK11A0.75468769
81MAP3K100.75362767
82GRK50.74106856
83RIPK10.73389061
84CAMKK20.70018660
85PRKCZ0.69460768
86PHKG20.69333340
87PHKG10.69333340
88PAK30.68241583
89MKNK10.68057656
90SGK10.66156514
91GRK70.65882977
92LATS10.64907908
93PLK20.64380208
94PRKCQ0.64061490
95PINK10.61615562
96MAP3K90.56719874
97DYRK30.56332169
98RPS6KA50.56089458
99PRKCH0.55572837
100MAPK100.53827672
101MUSK0.53444310
102ERBB20.52226799
103PTK2B0.51707991
104FYN0.51486615
105MAP3K40.51079461
106MAP2K70.50926886
107PRKG10.47374056
108ERBB40.46206317
109PRKD10.45732719
110MINK10.45276867
111FES0.45227355
112PDGFRB0.44866974
113RPS6KA30.44212826
114PRKD30.44107054
115IRAK20.44070148
116CSNK1D0.43054238
117NEK20.42656464
118DAPK30.42289899
119CSNK1E0.41998267
120RPS6KA20.41515986
121EPHA30.41417983
122DYRK1A0.40573678
123PDGFRA0.39453824
124CSNK1A10.39340427
125PDPK10.35421836
126ALK0.35054503
127BMPR20.34994439
128GSK3B0.34623683
129STK160.33320783
130PRKACB0.33085405
131YES10.32808423
132MAP3K130.32520278
133MAP3K120.31766595
134PRKACA0.31090414
135PLK40.30323401
136MAPK80.30289902
137CDK30.30283412
138TRPM70.29871130
139GSK3A0.28730612
140PRKCG0.28598291
141ADRBK10.28525446
142CAMK1G0.28486889
143RET0.27801055
144GRK10.27718653
145ROCK10.27441103

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.98252112
2Steroid biosynthesis_Homo sapiens_hsa001003.99922048
3Fatty acid elongation_Homo sapiens_hsa000623.66771406
4Ether lipid metabolism_Homo sapiens_hsa005652.89405269
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.85536416
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.44992158
7Oxidative phosphorylation_Homo sapiens_hsa001902.44360670
8Sphingolipid metabolism_Homo sapiens_hsa006002.02667070
9Axon guidance_Homo sapiens_hsa043601.97627827
10Collecting duct acid secretion_Homo sapiens_hsa049661.90884833
11Serotonergic synapse_Homo sapiens_hsa047261.89564593
12Parkinsons disease_Homo sapiens_hsa050121.77162786
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72964116
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65674020
15Alzheimers disease_Homo sapiens_hsa050101.63317275
16Synaptic vesicle cycle_Homo sapiens_hsa047211.62437805
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59410586
18Basal cell carcinoma_Homo sapiens_hsa052171.58922770
19GABAergic synapse_Homo sapiens_hsa047271.58586313
20Glutamatergic synapse_Homo sapiens_hsa047241.56042454
21Nicotine addiction_Homo sapiens_hsa050331.55007971
22Linoleic acid metabolism_Homo sapiens_hsa005911.52686308
23Notch signaling pathway_Homo sapiens_hsa043301.49561710
24Vibrio cholerae infection_Homo sapiens_hsa051101.48968042
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43585396
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.41791197
27Sulfur metabolism_Homo sapiens_hsa009201.41772218
28Long-term depression_Homo sapiens_hsa047301.41116538
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35954415
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34920129
31Morphine addiction_Homo sapiens_hsa050321.34493936
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34436933
33Protein export_Homo sapiens_hsa030601.32198544
34Cocaine addiction_Homo sapiens_hsa050301.27503645
35Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.26625301
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22997092
37Circadian entrainment_Homo sapiens_hsa047131.19546116
38Hippo signaling pathway_Homo sapiens_hsa043901.18935844
39Rheumatoid arthritis_Homo sapiens_hsa053231.18810486
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18073842
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.13925881
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13639940
43Type II diabetes mellitus_Homo sapiens_hsa049301.11209168
44Histidine metabolism_Homo sapiens_hsa003401.10936716
45Dopaminergic synapse_Homo sapiens_hsa047281.07204293
46Colorectal cancer_Homo sapiens_hsa052101.04487477
47Estrogen signaling pathway_Homo sapiens_hsa049151.03869068
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03202661
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02962807
50Renal cell carcinoma_Homo sapiens_hsa052111.02163662
51Cholinergic synapse_Homo sapiens_hsa047251.01210293
52Salivary secretion_Homo sapiens_hsa049701.00732018
53Huntingtons disease_Homo sapiens_hsa050161.00271197
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.97507563
55Vitamin B6 metabolism_Homo sapiens_hsa007500.97387585
56Mineral absorption_Homo sapiens_hsa049780.95783143
57Phototransduction_Homo sapiens_hsa047440.94601653
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90740632
59Taste transduction_Homo sapiens_hsa047420.89619201
60Tight junction_Homo sapiens_hsa045300.89394961
61VEGF signaling pathway_Homo sapiens_hsa043700.88628234
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88419760
63Phagosome_Homo sapiens_hsa041450.88365096
64Cardiac muscle contraction_Homo sapiens_hsa042600.86297427
65Endometrial cancer_Homo sapiens_hsa052130.86134326
66Arachidonic acid metabolism_Homo sapiens_hsa005900.84123882
67Ras signaling pathway_Homo sapiens_hsa040140.81943408
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.81413827
69Amphetamine addiction_Homo sapiens_hsa050310.81117739
70Glioma_Homo sapiens_hsa052140.80239208
71Gastric acid secretion_Homo sapiens_hsa049710.79174018
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78767294
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77605160
74Prolactin signaling pathway_Homo sapiens_hsa049170.73320213
75Butanoate metabolism_Homo sapiens_hsa006500.73226914
76Gap junction_Homo sapiens_hsa045400.72539059
77Adherens junction_Homo sapiens_hsa045200.72292711
78Dilated cardiomyopathy_Homo sapiens_hsa054140.72083100
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71980445
80Ovarian steroidogenesis_Homo sapiens_hsa049130.71599376
81Autoimmune thyroid disease_Homo sapiens_hsa053200.70928320
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70829562
83Renin secretion_Homo sapiens_hsa049240.69930965
84Olfactory transduction_Homo sapiens_hsa047400.68226292
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66991537
86Endocytosis_Homo sapiens_hsa041440.64869401
87ErbB signaling pathway_Homo sapiens_hsa040120.64850037
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64173538
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64073734
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63154219
91Hedgehog signaling pathway_Homo sapiens_hsa043400.60657728
92Inositol phosphate metabolism_Homo sapiens_hsa005620.59975549
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59760188
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59331882
95MicroRNAs in cancer_Homo sapiens_hsa052060.58950738
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57678993
97Lysosome_Homo sapiens_hsa041420.56446524
98Long-term potentiation_Homo sapiens_hsa047200.56334263
99Dorso-ventral axis formation_Homo sapiens_hsa043200.55538551
100Alcoholism_Homo sapiens_hsa050340.54643540
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53766747
102Pancreatic secretion_Homo sapiens_hsa049720.52896620
103Arginine and proline metabolism_Homo sapiens_hsa003300.52059909
104Calcium signaling pathway_Homo sapiens_hsa040200.51827757
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51192737
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50309654
107Oocyte meiosis_Homo sapiens_hsa041140.49421792
108Pathways in cancer_Homo sapiens_hsa052000.49407235
109* Phospholipase D signaling pathway_Homo sapiens_hsa040720.48445968
110Chemokine signaling pathway_Homo sapiens_hsa040620.46558604
111ECM-receptor interaction_Homo sapiens_hsa045120.46336441
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45838549
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45694291
114Oxytocin signaling pathway_Homo sapiens_hsa049210.45429567
115Insulin secretion_Homo sapiens_hsa049110.45306590
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44673461
117Melanogenesis_Homo sapiens_hsa049160.43383516
118FoxO signaling pathway_Homo sapiens_hsa040680.43197985
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42952434
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42882043
121Thyroid hormone synthesis_Homo sapiens_hsa049180.42677511
122GnRH signaling pathway_Homo sapiens_hsa049120.42343104
123mTOR signaling pathway_Homo sapiens_hsa041500.42329452
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42009862
125cAMP signaling pathway_Homo sapiens_hsa040240.41484938
126Choline metabolism in cancer_Homo sapiens_hsa052310.38742811
127MAPK signaling pathway_Homo sapiens_hsa040100.37125373
128Prion diseases_Homo sapiens_hsa050200.36639799
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35976150
130African trypanosomiasis_Homo sapiens_hsa051430.35757793
131Salmonella infection_Homo sapiens_hsa051320.35338282
132Glutathione metabolism_Homo sapiens_hsa004800.34205596
133Malaria_Homo sapiens_hsa051440.33606888
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33318409
135Wnt signaling pathway_Homo sapiens_hsa043100.32108265
136* Glycerophospholipid metabolism_Homo sapiens_hsa005640.27116607
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26969775
138Rap1 signaling pathway_Homo sapiens_hsa040150.26579869

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