AGPAT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.56408648
2nuclear pore organization (GO:0006999)4.91294114
3cellular potassium ion homeostasis (GO:0030007)4.83705915
4establishment of integrated proviral latency (GO:0075713)4.82738625
5mitotic chromosome condensation (GO:0007076)4.66703665
6sodium ion export (GO:0071436)4.65001698
7mitotic sister chromatid cohesion (GO:0007064)4.53702914
8DNA deamination (GO:0045006)4.44758815
9DNA replication-dependent nucleosome assembly (GO:0006335)4.11220136
10DNA replication-dependent nucleosome organization (GO:0034723)4.11220136
11DNA double-strand break processing (GO:0000729)4.10650433
12neurotransmitter uptake (GO:0001504)4.09145861
13amino acid import (GO:0043090)3.97178846
14pore complex assembly (GO:0046931)3.96454532
15DNA topological change (GO:0006265)3.96183241
16sister chromatid segregation (GO:0000819)3.93846790
17DNA strand elongation involved in DNA replication (GO:0006271)3.91608938
18mitotic sister chromatid segregation (GO:0000070)3.90471183
19regulation of centriole replication (GO:0046599)3.89646139
20non-recombinational repair (GO:0000726)3.86879424
21double-strand break repair via nonhomologous end joining (GO:0006303)3.86879424
22DNA replication initiation (GO:0006270)3.84223411
23positive regulation of chromosome segregation (GO:0051984)3.83282205
24L-amino acid import (GO:0043092)3.83062976
25DNA strand elongation (GO:0022616)3.82816300
26cell communication by electrical coupling (GO:0010644)3.81764813
27IMP biosynthetic process (GO:0006188)3.79689276
28regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.72932322
29mitotic nuclear envelope disassembly (GO:0007077)3.70939802
30regulation of histone H3-K9 methylation (GO:0051570)3.69249691
31telomere maintenance via semi-conservative replication (GO:0032201)3.67571373
32DNA duplex unwinding (GO:0032508)3.61566414
33formation of translation preinitiation complex (GO:0001731)3.60257393
34DNA replication checkpoint (GO:0000076)3.58746708
35CENP-A containing nucleosome assembly (GO:0034080)3.58007186
36chromatin remodeling at centromere (GO:0031055)3.57980513
37nucleobase biosynthetic process (GO:0046112)3.56959960
38negative regulation of chromosome segregation (GO:0051985)3.56529469
39DNA geometric change (GO:0032392)3.56258722
40atrial cardiac muscle cell action potential (GO:0086014)3.56025894
41establishment of viral latency (GO:0019043)3.55264893
42folic acid-containing compound biosynthetic process (GO:0009396)3.55166172
43pre-miRNA processing (GO:0031054)3.54287403
44negative regulation of mitotic sister chromatid separation (GO:2000816)3.54219897
45negative regulation of sister chromatid segregation (GO:0033046)3.54219897
46negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.54219897
47negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.54219897
48negative regulation of mitotic sister chromatid segregation (GO:0033048)3.54219897
49spindle checkpoint (GO:0031577)3.54151846
50regulation of chromosome segregation (GO:0051983)3.53486614
51regulation of mitotic metaphase/anaphase transition (GO:0030071)3.52666582
52regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.52666582
53C4-dicarboxylate transport (GO:0015740)3.51589186
54purine nucleobase biosynthetic process (GO:0009113)3.47071022
55mitotic spindle checkpoint (GO:0071174)3.46115557
56somatic hypermutation of immunoglobulin genes (GO:0016446)3.45691563
57somatic diversification of immune receptors via somatic mutation (GO:0002566)3.45691563
58nuclear envelope disassembly (GO:0051081)3.44969278
59membrane disassembly (GO:0030397)3.44969278
60negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.42660704
61ATP-dependent chromatin remodeling (GO:0043044)3.41717990
62regulation of mitotic sister chromatid separation (GO:0010965)3.40137871
63regulation of mitotic sister chromatid segregation (GO:0033047)3.40137871
64regulation of sister chromatid segregation (GO:0033045)3.40137871
65DNA ligation (GO:0006266)3.37824943
66regulation of DNA endoreduplication (GO:0032875)3.35941989
67establishment of chromosome localization (GO:0051303)3.33989447
68regulation of sister chromatid cohesion (GO:0007063)3.33026071
69ribosomal small subunit assembly (GO:0000028)3.32878362
70transcription from mitochondrial promoter (GO:0006390)3.31654973
71translesion synthesis (GO:0019985)3.31489095
72mitotic spindle assembly checkpoint (GO:0007094)3.29994573
73IMP metabolic process (GO:0046040)3.29235012
74DNA unwinding involved in DNA replication (GO:0006268)3.28492215
75regulation of centrosome cycle (GO:0046605)3.26003579
76spindle assembly checkpoint (GO:0071173)3.24746654
77cellular sodium ion homeostasis (GO:0006883)3.24643912
78gamma-aminobutyric acid transport (GO:0015812)3.22580843
79negative regulation of mRNA processing (GO:0050686)3.20395109
80cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20270349
81ribosome assembly (GO:0042255)3.18229788
82regulation of respiratory system process (GO:0044065)3.16588172
83neuron cell-cell adhesion (GO:0007158)3.16150426
84ribosome biogenesis (GO:0042254)3.14357847
85pseudouridine synthesis (GO:0001522)3.14204214
86protein complex localization (GO:0031503)3.14151225
87locomotory exploration behavior (GO:0035641)3.13063880
88chromatin assembly or disassembly (GO:0006333)3.12963833
89negative regulation of mRNA metabolic process (GO:1903312)3.12870405
90DNA conformation change (GO:0071103)3.12142309
91retinal rod cell development (GO:0046548)3.11081619
92maturation of SSU-rRNA (GO:0030490)3.10257511
93axon ensheathment in central nervous system (GO:0032291)3.08805059
94central nervous system myelination (GO:0022010)3.08805059
95GMP metabolic process (GO:0046037)3.08346165
96protein localization to chromosome (GO:0034502)3.06984608
97regulation of translational fidelity (GO:0006450)3.06242785
98telomere maintenance via recombination (GO:0000722)3.04645927
99postreplication repair (GO:0006301)3.04582415
100regulation of centrosome duplication (GO:0010824)3.04132846
101negative regulation of RNA splicing (GO:0033119)3.03335103
102regulation of mitotic spindle organization (GO:0060236)3.03311294
103telomere maintenance (GO:0000723)3.01134708
104regulation of spindle organization (GO:0090224)3.00821562
105heterochromatin organization (GO:0070828)3.00186150
106replication fork processing (GO:0031297)2.99469188
107mitotic recombination (GO:0006312)2.99230946
108telomere organization (GO:0032200)2.98421633
109mitochondrial RNA metabolic process (GO:0000959)2.97817895
110DNA replication-independent nucleosome organization (GO:0034724)2.97337423
111DNA replication-independent nucleosome assembly (GO:0006336)2.97337423
112positive regulation of mitotic sister chromatid separation (GO:1901970)2.95915179
113positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.95915179
114mitotic metaphase plate congression (GO:0007080)2.93259129
115rRNA metabolic process (GO:0016072)2.92627475
116transcription elongation from RNA polymerase III promoter (GO:0006385)2.92545579
117termination of RNA polymerase III transcription (GO:0006386)2.92545579
118rRNA processing (GO:0006364)2.91235815
119ribosomal large subunit biogenesis (GO:0042273)2.90914797
120kinetochore organization (GO:0051383)2.88943546
121kinetochore assembly (GO:0051382)2.88755882
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88469346
123ribonucleoprotein complex biogenesis (GO:0022613)2.87763799
124potassium ion homeostasis (GO:0055075)2.86228673
125negative regulation of astrocyte differentiation (GO:0048712)2.85603849
126histone exchange (GO:0043486)2.85455454
127G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85205729
128membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.84946395
129regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81603137
130telomere maintenance via telomere lengthening (GO:0010833)2.78420258
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.78239846
132attachment of spindle microtubules to kinetochore (GO:0008608)2.76716254
133establishment of protein localization to mitochondrial membrane (GO:0090151)2.76560418
134daunorubicin metabolic process (GO:0044597)2.74944851
135polyketide metabolic process (GO:0030638)2.74944851
136doxorubicin metabolic process (GO:0044598)2.74944851
137tRNA methylation (GO:0030488)2.74881232
138potassium ion import (GO:0010107)2.70100074
139regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.69940666
140nucleotide-excision repair, DNA gap filling (GO:0006297)2.68081975
141protein localization to kinetochore (GO:0034501)2.67605552
142transcription elongation from RNA polymerase I promoter (GO:0006362)2.66934766
143neuronal action potential propagation (GO:0019227)2.64409088
144regulation of respiratory gaseous exchange (GO:0043576)2.57537678
145protein localization to chromosome, centromeric region (GO:0071459)2.55679043
146fucose catabolic process (GO:0019317)2.52579107
147L-fucose metabolic process (GO:0042354)2.52579107
148L-fucose catabolic process (GO:0042355)2.52579107
149transcription-coupled nucleotide-excision repair (GO:0006283)2.51428434
150retinal cone cell development (GO:0046549)2.50187395
151cellular component biogenesis (GO:0044085)2.48085812
152regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.47839576
153metaphase plate congression (GO:0051310)2.47129228
154deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.46707373
155L-serine transport (GO:0015825)2.46087494
156exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45674232
157positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.45633613
158postsynaptic membrane organization (GO:0001941)2.45464638
159presynaptic membrane assembly (GO:0097105)2.44568377
160spliceosomal snRNP assembly (GO:0000387)2.42455953
161skeletal muscle tissue regeneration (GO:0043403)2.41596739
1627-methylguanosine mRNA capping (GO:0006370)2.41239421
163termination of RNA polymerase I transcription (GO:0006363)2.40888925
164maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.38682695
165L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.37582742
166proteasome assembly (GO:0043248)2.37161612
167rhodopsin mediated signaling pathway (GO:0016056)2.37156997
168translational termination (GO:0006415)2.36809201
169respiratory chain complex IV assembly (GO:0008535)2.36649166
170protein heterotetramerization (GO:0051290)2.36055402
171ribosomal small subunit biogenesis (GO:0042274)2.35192976
1727-methylguanosine RNA capping (GO:0009452)2.35154858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.44222241
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.78851775
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.22262814
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.58498305
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.47256763
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.01356229
7* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.97400295
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90904090
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87607937
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81507905
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71428787
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.70267655
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.69542055
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.60241970
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.59845030
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58387343
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.46046691
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43439725
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.31336651
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29881498
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23630043
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22696441
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18188730
24AR_21909140_ChIP-Seq_LNCAP_Human2.15604913
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05002796
26VDR_23849224_ChIP-Seq_CD4+_Human1.94354512
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93948521
28XRN2_22483619_ChIP-Seq_HELA_Human1.82967012
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82790724
30* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82295692
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78046404
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.77758853
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76437256
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69420840
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67817881
36* TTF2_22483619_ChIP-Seq_HELA_Human1.67767159
37DCP1A_22483619_ChIP-Seq_HELA_Human1.65483957
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65311487
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57462957
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56450806
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.55913347
42FUS_26573619_Chip-Seq_HEK293_Human1.54837471
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54741936
44FOXP3_21729870_ChIP-Seq_TREG_Human1.54246793
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52048599
46* GABP_19822575_ChIP-Seq_HepG2_Human1.49382603
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46789211
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45678654
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41829637
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40271586
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36045760
52CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.35970671
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33446107
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31350744
55MYC_18940864_ChIP-ChIP_HL60_Human1.30137986
56NANOG_16153702_ChIP-ChIP_HESCs_Human1.30036809
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28226088
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25309461
59IGF1R_20145208_ChIP-Seq_DFB_Human1.24266691
60MYC_22102868_ChIP-Seq_BL_Human1.23294692
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.23235901
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23071320
63AR_21572438_ChIP-Seq_LNCaP_Human1.21922827
64ELK1_19687146_ChIP-ChIP_HELA_Human1.20449056
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19201393
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.17743582
67EWS_26573619_Chip-Seq_HEK293_Human1.17296684
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14534514
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.14288329
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12286125
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10529137
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.07179273
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07088134
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02190921
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01604510
76* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99911626
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99077906
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97787244
79GBX2_23144817_ChIP-Seq_PC3_Human0.97191504
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97163573
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96812719
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96653389
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96317621
84SOX17_20123909_ChIP-Seq_XEN_Mouse0.95473615
85KDM5A_27292631_Chip-Seq_BREAST_Human0.93736566
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93000506
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91889357
88* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90870420
89* REST_21632747_ChIP-Seq_MESCs_Mouse0.90823125
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.88767946
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87910729
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.86681094
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84606135
94* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84533921
95* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84384781
96NANOG_21062744_ChIP-ChIP_HESCs_Human0.83408295
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82786737
98* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82529998
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81791609
100EZH2_22144423_ChIP-Seq_EOC_Human0.80694664
101TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80553159
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78212234
103CHD1_26751641_Chip-Seq_LNCaP_Human0.77734110
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77225096
105IRF1_19129219_ChIP-ChIP_H3396_Human0.77206333
106FLI1_27457419_Chip-Seq_LIVER_Mouse0.75829945
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.74636851
108TCF3_18692474_ChIP-Seq_MESCs_Mouse0.73218821
109CTBP2_25329375_ChIP-Seq_LNCAP_Human0.73111556
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73094407
111* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72967083
112TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.72537288
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70773625
114* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.70672830
115* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.70668271
116CIITA_25753668_ChIP-Seq_RAJI_Human0.68962278
117* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.68329244
118* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.67382320
119CTCF_18555785_ChIP-Seq_MESCs_Mouse0.66468680
120* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.65167886
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.63950740
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63345488
123REST_18959480_ChIP-ChIP_MESCs_Mouse0.62201080
124* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.60556862
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.59893041
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.58896724
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.58660095

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous4.28593782
2MP0003136_yellow_coat_color2.94318359
3MP0004885_abnormal_endolymph2.91937588
4MP0003693_abnormal_embryo_hatching2.68192707
5MP0002638_abnormal_pupillary_reflex2.47816094
6MP0003011_delayed_dark_adaptation2.47114313
7MP0005551_abnormal_eye_electrophysiolog2.45259256
8MP0003880_abnormal_central_pattern2.41672843
9MP0001485_abnormal_pinna_reflex2.39705842
10MP0010094_abnormal_chromosome_stability2.30987856
11MP0003890_abnormal_embryonic-extraembry2.25655471
12MP0009697_abnormal_copulation2.22018960
13MP0004270_analgesia2.19828446
14MP0005171_absent_coat_pigmentation2.18645237
15MP0003111_abnormal_nucleus_morphology2.08825132
16MP0009046_muscle_twitch2.05333974
17MP0003950_abnormal_plasma_membrane2.03655704
18MP0006072_abnormal_retinal_apoptosis2.03465081
19MP0001486_abnormal_startle_reflex2.01138119
20MP0010352_gastrointestinal_tract_polyps1.97061339
21MP0003878_abnormal_ear_physiology1.96947163
22MP0005377_hearing/vestibular/ear_phenot1.96947163
23MP0008057_abnormal_DNA_replication1.95835112
24MP0004858_abnormal_nervous_system1.95307095
25MP0009672_abnormal_birth_weight1.90394213
26MP0004957_abnormal_blastocyst_morpholog1.89477975
27MP0005253_abnormal_eye_physiology1.86829589
28MP0001188_hyperpigmentation1.84680401
29MP0010307_abnormal_tumor_latency1.80812105
30MP0009379_abnormal_foot_pigmentation1.78296693
31MP0001697_abnormal_embryo_size1.73841168
32MP0001986_abnormal_taste_sensitivity1.73553209
33MP0001672_abnormal_embryogenesis/_devel1.68349072
34MP0005380_embryogenesis_phenotype1.68349072
35MP0003635_abnormal_synaptic_transmissio1.63700966
36MP0003329_amyloid_beta_deposits1.63483693
37MP0002084_abnormal_developmental_patter1.63411956
38MP0006292_abnormal_olfactory_placode1.60612755
39MP0010234_abnormal_vibrissa_follicle1.59328104
40MP0002085_abnormal_embryonic_tissue1.57813679
41MP0003077_abnormal_cell_cycle1.57501726
42MP0004197_abnormal_fetal_growth/weight/1.56955596
43MP0003183_abnormal_peptide_metabolism1.56025096
44MP0003937_abnormal_limbs/digits/tail_de1.54689679
45MP0002396_abnormal_hematopoietic_system1.53936378
46MP0004859_abnormal_synaptic_plasticity1.51994203
47MP0002080_prenatal_lethality1.51494292
48MP0008058_abnormal_DNA_repair1.49033596
49MP0001529_abnormal_vocalization1.49009195
50MP0003984_embryonic_growth_retardation1.48199188
51MP0001502_abnormal_circadian_rhythm1.46464950
52MP0002272_abnormal_nervous_system1.43285894
53MP0002088_abnormal_embryonic_growth/wei1.42842345
54MP0002734_abnormal_mechanical_nocicepti1.42282974
55MP0003123_paternal_imprinting1.39525206
56MP0002064_seizures1.37766147
57MP0004142_abnormal_muscle_tone1.36292313
58MP0002697_abnormal_eye_size1.36110797
59MP0008932_abnormal_embryonic_tissue1.35578499
60MP0003718_maternal_effect1.32873906
61MP0009745_abnormal_behavioral_response1.32184335
62MP0002572_abnormal_emotion/affect_behav1.31344205
63MP0001968_abnormal_touch/_nociception1.30559510
64MP0000372_irregular_coat_pigmentation1.30005469
65MP0003941_abnormal_skin_development1.28003914
66MP0009703_decreased_birth_body1.27351671
67MP0002009_preneoplasia1.26491849
68MP0003172_abnormal_lysosome_physiology1.26143503
69MP0002163_abnormal_gland_morphology1.25172465
70MP0003690_abnormal_glial_cell1.25119403
71MP0005394_taste/olfaction_phenotype1.24069534
72MP0005499_abnormal_olfactory_system1.24069534
73MP0003567_abnormal_fetal_cardiomyocyte1.22936998
74MP0001440_abnormal_grooming_behavior1.22276362
75MP0002086_abnormal_extraembryonic_tissu1.21421311
76MP0000313_abnormal_cell_death1.20866386
77MP0004147_increased_porphyrin_level1.20551244
78MP0002229_neurodegeneration1.20472831
79MP0002067_abnormal_sensory_capabilities1.20360786
80MP0004742_abnormal_vestibular_system1.20184905
81MP0008789_abnormal_olfactory_epithelium1.20152743
82MP0008877_abnormal_DNA_methylation1.19968317
83MP0009780_abnormal_chondrocyte_physiolo1.19315597
84MP0000566_synostosis1.18765935
85MP0002063_abnormal_learning/memory/cond1.18639967
86MP0001905_abnormal_dopamine_level1.17513121
87MP0006035_abnormal_mitochondrial_morpho1.15763680
88MP0002233_abnormal_nose_morphology1.14878742
89MP0001853_heart_inflammation1.14443452
90MP0003634_abnormal_glial_cell1.12911132
91MP0001286_abnormal_eye_development1.12374786
92MP0000428_abnormal_craniofacial_morphol1.11295597
93MP0005409_darkened_coat_color1.10465609
94MP0001963_abnormal_hearing_physiology1.10028028
95MP0005623_abnormal_meninges_morphology1.09098647
96MP0004215_abnormal_myocardial_fiber1.08481539
97MP0003786_premature_aging1.06562851
98MP0001984_abnormal_olfaction1.05547504
99MP0003861_abnormal_nervous_system1.05233487
100MP0005379_endocrine/exocrine_gland_phen1.03181769
101MP0000015_abnormal_ear_pigmentation1.01352448
102MP0008569_lethality_at_weaning1.00545300
103MP0005174_abnormal_tail_pigmentation0.99375369
104MP0005646_abnormal_pituitary_gland0.98573548
105MP0002877_abnormal_melanocyte_morpholog0.98346028
106MP0002111_abnormal_tail_morphology0.97350593
107MP0005391_vision/eye_phenotype0.97125941
108MP0000579_abnormal_nail_morphology0.96981725
109MP0004924_abnormal_behavior0.96528801
110MP0005386_behavior/neurological_phenoty0.96528801
111MP0000537_abnormal_urethra_morphology0.95383093
112MP0003121_genomic_imprinting0.95182712
113MP0002882_abnormal_neuron_morphology0.95050173
114MP0004808_abnormal_hematopoietic_stem0.95027879
115MP0002089_abnormal_postnatal_growth/wei0.93857131
116MP0000358_abnormal_cell_content/0.92956835
117MP0005195_abnormal_posterior_eye0.92789781
118MP0002736_abnormal_nociception_after0.92681532
119MP0002210_abnormal_sex_determination0.91785544
120MP0003632_abnormal_nervous_system0.91617900
121MP0002095_abnormal_skin_pigmentation0.91402473
122MP0000049_abnormal_middle_ear0.90340976
123MP0002092_abnormal_eye_morphology0.89163602
124MP0000490_abnormal_crypts_of0.88465061
125MP0001293_anophthalmia0.87780572
126MP0002090_abnormal_vision0.87365913
127MP0001177_atelectasis0.86761305
128MP0003119_abnormal_digestive_system0.86018247
129MP0002557_abnormal_social/conspecific_i0.85775612
130MP0002752_abnormal_somatic_nervous0.85689358
131MP0000465_gastrointestinal_hemorrhage0.83625118
132MP0004185_abnormal_adipocyte_glucose0.82640704
133MP0000350_abnormal_cell_proliferation0.81810894
134MP0005076_abnormal_cell_differentiation0.80478843
135MP0000026_abnormal_inner_ear0.80404490
136MP0001929_abnormal_gametogenesis0.80281074
137MP0002177_abnormal_outer_ear0.79420990
138MP0005384_cellular_phenotype0.79207684
139MP0001145_abnormal_male_reproductive0.79179194
140MP0003935_abnormal_craniofacial_develop0.78365911
141MP0005645_abnormal_hypothalamus_physiol0.77812030
142MP0000778_abnormal_nervous_system0.76805910
143MP0001970_abnormal_pain_threshold0.76672597
144MP0010678_abnormal_skin_adnexa0.75712023
145MP0002938_white_spotting0.74735665
146MP0002066_abnormal_motor_capabilities/c0.74364546
147MP0005451_abnormal_body_composition0.74360938
148MP0003221_abnormal_cardiomyocyte_apopto0.74223261
149MP0009384_cardiac_valve_regurgitation0.74124083
150MP0002733_abnormal_thermal_nociception0.73974534
151MP0000762_abnormal_tongue_morphology0.73940666
152MP0001730_embryonic_growth_arrest0.73802296
153MP0002081_perinatal_lethality0.73800081
154MP0003315_abnormal_perineum_morphology0.73663471
155MP0002184_abnormal_innervation0.73570783
156MP0002152_abnormal_brain_morphology0.72602817
157MP0003385_abnormal_body_wall0.72579715
158MP0002234_abnormal_pharynx_morphology0.72047075
159MP0000631_abnormal_neuroendocrine_gland0.71937684
160MP0002019_abnormal_tumor_incidence0.70994424
161MP0001346_abnormal_lacrimal_gland0.70622583
162MP0005621_abnormal_cell_physiology0.69567158
163MP0005220_abnormal_exocrine_pancreas0.69473310
164MP0008007_abnormal_cellular_replicative0.69278619
165MP0001299_abnormal_eye_distance/0.67422552
166MP0000432_abnormal_head_morphology0.66699600
167MP0000653_abnormal_sex_gland0.66265368
168MP0002751_abnormal_autonomic_nervous0.63943128
169MP0003755_abnormal_palate_morphology0.63623785
170MP0001727_abnormal_embryo_implantation0.62739340
171MP0005501_abnormal_skin_physiology0.56012763
172MP0005187_abnormal_penis_morphology0.55805092
173MP0003943_abnormal_hepatobiliary_system0.55024592

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.31245244
2Abnormality of binocular vision (HP:0011514)4.20477151
3Diplopia (HP:0000651)4.20477151
4Chromsome breakage (HP:0040012)4.18805624
5Broad alveolar ridges (HP:0000187)3.64811305
6Abnormality of chromosome stability (HP:0003220)3.50251262
7Birth length less than 3rd percentile (HP:0003561)3.41396165
8Nephroblastoma (Wilms tumor) (HP:0002667)3.37346135
9Megalencephaly (HP:0001355)3.29679146
10Abnormality of secondary sexual hair (HP:0009888)3.28409187
11Abnormality of the axillary hair (HP:0100134)3.28409187
12Meckel diverticulum (HP:0002245)3.24396251
13Embryonal renal neoplasm (HP:0011794)3.23733785
14Cerebral hypomyelination (HP:0006808)3.15827542
15Hemiparesis (HP:0001269)3.11043945
16Abnormality of the ileum (HP:0001549)3.05299500
17Increased nuchal translucency (HP:0010880)3.03877663
18Medulloblastoma (HP:0002885)3.02567434
19Volvulus (HP:0002580)2.99795166
20Abnormality of the preputium (HP:0100587)2.99691775
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.92815540
22Aplasia involving bones of the extremities (HP:0009825)2.90555113
23Aplasia involving bones of the upper limbs (HP:0009823)2.90555113
24Aplasia of the phalanges of the hand (HP:0009802)2.90555113
25Abnormal lung lobation (HP:0002101)2.89386606
26Short middle phalanx of the 5th finger (HP:0004220)2.87280952
27Congenital stationary night blindness (HP:0007642)2.85073004
28Cortical dysplasia (HP:0002539)2.81693519
29Morphological abnormality of the inner ear (HP:0011390)2.76753888
30Hypoglycemic seizures (HP:0002173)2.74790839
31Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.70494660
32J-shaped sella turcica (HP:0002680)2.64578487
33Selective tooth agenesis (HP:0001592)2.60628131
34Hypoplastic left heart (HP:0004383)2.59552219
35Small intestinal stenosis (HP:0012848)2.54970316
36Duodenal stenosis (HP:0100867)2.54970316
37Aplasia/Hypoplasia of the sternum (HP:0006714)2.51161905
38Rhabdomyosarcoma (HP:0002859)2.48613183
39Carpal bone hypoplasia (HP:0001498)2.48348414
40Abnormality of the carotid arteries (HP:0005344)2.48240455
41Overlapping toe (HP:0001845)2.45937503
42Abnormal number of erythroid precursors (HP:0012131)2.45175060
43Hemiplegia (HP:0002301)2.43222735
44Focal motor seizures (HP:0011153)2.42128687
45Myelodysplasia (HP:0002863)2.41947345
46Abnormality of cells of the erythroid lineage (HP:0012130)2.41632410
47Abnormality of the duodenum (HP:0002246)2.38284659
48Multiple enchondromatosis (HP:0005701)2.31252257
49Abnormality of nail color (HP:0100643)2.27272561
50Long nose (HP:0003189)2.27065657
51Increased hepatocellular lipid droplets (HP:0006565)2.26166760
52Pancreatic islet-cell hyperplasia (HP:0004510)2.25618443
53Progressive external ophthalmoplegia (HP:0000590)2.24412667
54Split foot (HP:0001839)2.20920826
55Missing ribs (HP:0000921)2.20894697
56Epileptic encephalopathy (HP:0200134)2.18923245
57CNS hypomyelination (HP:0003429)2.18649826
58Embryonal neoplasm (HP:0002898)2.18336586
59Ectopic kidney (HP:0000086)2.16754059
60Cafe-au-lait spot (HP:0000957)2.15146429
61Supernumerary spleens (HP:0009799)2.12874533
62Hyperinsulinemic hypoglycemia (HP:0000825)2.11076362
63Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.10691726
64Blepharitis (HP:0000498)2.08886637
65Spastic diplegia (HP:0001264)2.08127127
66Neoplasm of the adrenal cortex (HP:0100641)2.06384644
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04752907
68Oligodactyly (hands) (HP:0001180)2.04604847
69Hypoplastic heart (HP:0001961)2.04585669
70Sloping forehead (HP:0000340)2.03179640
71Abnormality of methionine metabolism (HP:0010901)2.02965567
72Papillary thyroid carcinoma (HP:0002895)2.01102326
73Severe global developmental delay (HP:0011344)2.00302004
74Neoplasm of the colon (HP:0100273)1.97944212
75Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.97417535
76Onycholysis (HP:0001806)1.97251989
77Skull defect (HP:0001362)1.95100682
78Abnormality of endocrine pancreas physiology (HP:0012093)1.95027166
79Abnormality of the pancreatic islet cells (HP:0006476)1.95027166
80Reticulocytopenia (HP:0001896)1.94606503
81Abnormality of the columella (HP:0009929)1.94176349
82Type I transferrin isoform profile (HP:0003642)1.93366589
83Mitochondrial inheritance (HP:0001427)1.93171272
84Hepatocellular necrosis (HP:0001404)1.92617950
85Confusion (HP:0001289)1.92557372
86Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92138214
87Clumsiness (HP:0002312)1.91254419
88Flared iliac wings (HP:0002869)1.90991853
89Brittle hair (HP:0002299)1.90943153
90Dry hair (HP:0011359)1.89999180
91Microvesicular hepatic steatosis (HP:0001414)1.89579952
92Hepatoblastoma (HP:0002884)1.88860923
93Fibular aplasia (HP:0002990)1.88687294
94Hypoplastic pelvis (HP:0008839)1.88652642
95Urethral obstruction (HP:0000796)1.87672364
96Bony spicule pigmentary retinopathy (HP:0007737)1.87501788
97Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.87179857
98Neoplasm of the small intestine (HP:0100833)1.87157824
99Rough bone trabeculation (HP:0100670)1.85147971
100Aplasia/hypoplasia of the uterus (HP:0008684)1.84256646
101Breast hypoplasia (HP:0003187)1.83537224
102Neoplasm of the adrenal gland (HP:0100631)1.83475460
103Horseshoe kidney (HP:0000085)1.82904518
104Absent septum pellucidum (HP:0001331)1.82804397
105Neoplasm of the peripheral nervous system (HP:0100007)1.82710268
106Abnormality of the umbilical cord (HP:0010881)1.82477004
107Ependymoma (HP:0002888)1.81955511
108Colon cancer (HP:0003003)1.81845072
109Abnormality of glycolysis (HP:0004366)1.81394013
110Progressive muscle weakness (HP:0003323)1.81197895
111Increased CSF lactate (HP:0002490)1.80986216
112Biliary tract neoplasm (HP:0100574)1.80526819
113Mutism (HP:0002300)1.80478344
114Glioma (HP:0009733)1.80457334
115Oligodactyly (HP:0012165)1.80355673
116Abnormal rod and cone electroretinograms (HP:0008323)1.80328441
117Premature graying of hair (HP:0002216)1.79953261
118Abnormality of the septum pellucidum (HP:0007375)1.79611257
119Abnormality of cochlea (HP:0000375)1.78629842
120IgA deficiency (HP:0002720)1.78396717
121Dyschromatopsia (HP:0007641)1.78357805
122Abnormality of the phalanges of the 5th finger (HP:0004213)1.78212661
123Squamous cell carcinoma (HP:0002860)1.78158386
124Ovarian neoplasm (HP:0100615)1.77718591
125Abnormality of chromosome segregation (HP:0002916)1.77639821
126Insomnia (HP:0100785)1.76553506
127Papilledema (HP:0001085)1.75147645
128Absent hair (HP:0002298)1.74581438
129Acute necrotizing encephalopathy (HP:0006965)1.73809016
130Aplasia involving forearm bones (HP:0009822)1.73439659
131Absent forearm bone (HP:0003953)1.73439659
132Sparse eyelashes (HP:0000653)1.73235980
133Shoulder girdle muscle weakness (HP:0003547)1.72867743
134Emotional lability (HP:0000712)1.72678902
135Facial hemangioma (HP:0000329)1.71776802
136Uterine neoplasm (HP:0010784)1.70191834
137Prominent metopic ridge (HP:0005487)1.70151801
138Gastrointestinal carcinoma (HP:0002672)1.69855461
139Malignant gastrointestinal tract tumors (HP:0006749)1.69855461
140Neuroendocrine neoplasm (HP:0100634)1.69630705
141Choanal atresia (HP:0000453)1.69616053
142Pheochromocytoma (HP:0002666)1.69611714
143Macrocytic anemia (HP:0001972)1.68597650
144Symptomatic seizures (HP:0011145)1.68126339
145Deep philtrum (HP:0002002)1.67890094
146Patellar aplasia (HP:0006443)1.67873479
147Hypoglycemic coma (HP:0001325)1.67575299
148Postnatal microcephaly (HP:0005484)1.67422066
149Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.67399332
150Triphalangeal thumb (HP:0001199)1.67349043
151Thyroid carcinoma (HP:0002890)1.66916660
152Tetraplegia (HP:0002445)1.66297465
153Microglossia (HP:0000171)1.66140494
154Absent radius (HP:0003974)1.65893903
155Maternal diabetes (HP:0009800)1.65578583
156Elfin facies (HP:0004428)1.65143016
157Asplenia (HP:0001746)1.64756270
158Generalized tonic-clonic seizures (HP:0002069)1.64546262
159Abnormality of the alveolar ridges (HP:0006477)1.64446698
160Unsteady gait (HP:0002317)1.63930473
161Clubbing of toes (HP:0100760)1.63860347
162IgM deficiency (HP:0002850)1.63527370
163Exercise-induced muscle cramps (HP:0003710)1.63390921
164Basal cell carcinoma (HP:0002671)1.62863452
165Abnormality of the labia minora (HP:0012880)1.62692543
166Capillary hemangiomas (HP:0005306)1.62224503
167Neoplasm of the oral cavity (HP:0100649)1.62090364
168Neurofibrillary tangles (HP:0002185)1.62018117
169Arteriovenous malformation (HP:0100026)1.61955703
170Ventricular fibrillation (HP:0001663)1.61744807
171Renal Fanconi syndrome (HP:0001994)1.61292315
172Septo-optic dysplasia (HP:0100842)1.60409552
173Leiomyosarcoma (HP:0100243)1.60311106
174Uterine leiomyosarcoma (HP:0002891)1.60311106
175High anterior hairline (HP:0009890)1.60143431
176Insidious onset (HP:0003587)1.59907513
177Termporal pattern (HP:0011008)1.59907513
178Lipid accumulation in hepatocytes (HP:0006561)1.59660647
179Esophageal atresia (HP:0002032)1.58630947
180Abnormality of hair growth rate (HP:0011363)1.58324784
181Slow-growing hair (HP:0002217)1.58324784
182Aplasia/Hypoplasia of the sacrum (HP:0008517)1.58278423
183Facial cleft (HP:0002006)1.56915128
184Transitional cell carcinoma of the bladder (HP:0006740)1.56337180
185Hyperglycinemia (HP:0002154)1.56072362
186Increased serum pyruvate (HP:0003542)1.54413227
187Acute myeloid leukemia (HP:0004808)1.54168974

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.16473453
2CDC73.07763400
3WEE13.07347910
4SRPK13.02022886
5TAF12.99876231
6MKNK22.98166217
7BUB12.93970262
8STK162.89766090
9MUSK2.63912039
10CASK2.48378932
11MKNK12.36534486
12PBK2.31066204
13MARK12.13843640
14EIF2AK12.10029349
15MAP3K102.08105598
16MST41.98157996
17ACVR1B1.79560570
18VRK21.70204036
19NME21.68525863
20BRD41.66218923
21PASK1.63316556
22EIF2AK31.59806844
23TSSK61.59055515
24SMG11.57270058
25VRK11.55768831
26TLK11.50721722
27NEK61.49365647
28CCNB11.47604085
29NEK11.44019168
30NTRK21.40125006
31MAPK131.39408982
32PLK31.39050053
33PLK11.38511354
34EEF2K1.36088581
35EPHA41.35411918
36PHKG11.35276402
37PHKG21.35276402
38SCYL21.30240054
39NEK21.28539291
40MINK11.25466750
41TTK1.24591041
42CHEK21.23345693
43CDK191.22347718
44STK241.21467780
45STK38L1.19805071
46STK31.12721768
47NME11.12538649
48CDK121.11506898
49NUAK11.06795968
50CLK11.04708987
51MAP3K90.97927604
52MAP2K70.97085210
53AURKB0.96871207
54BRSK10.96792809
55AURKA0.93953335
56DYRK1A0.92149370
57TRIM280.91308190
58RPS6KB20.89194755
59MAPKAPK30.87609170
60TEC0.87185801
61IRAK30.86307284
62ALK0.85894957
63LMTK20.85719222
64MAP3K80.85638283
65MAPKAPK50.85244841
66LATS20.84691396
67LATS10.84456371
68ATR0.84404031
69PRKCG0.84096709
70PINK10.83003889
71CDK140.82497344
72CDK150.78580296
73DYRK30.78375970
74YES10.77735455
75DYRK20.76804835
76BRSK20.76496972
77CDK70.76400768
78PLK40.76010169
79NTRK30.75079722
80CDK180.72905884
81CDK11A0.72277563
82CDK40.69340496
83CDK80.68953733
84FGFR10.67311733
85EIF2AK20.66161358
86MAPK120.65959139
87RPS6KA40.65872338
88CSNK1G20.65366175
89BCR0.64946185
90CDK60.64200300
91OXSR10.62985303
92CSNK1G10.62424728
93ERBB30.60873368
94PNCK0.60617300
95PRKD30.58999359
96CSNK2A20.58922759
97STK40.58454567
98CDK20.58156314
99ERBB40.57305558
100ZAK0.56425095
101BMPR1B0.55629318
102CHEK10.55122006
103PIK3CA0.55049012
104STK390.55042180
105CDK10.53956520
106MELK0.53306684
107CSNK1G30.52743389
108ADRBK10.52577848
109PIM20.52287028
110DAPK10.52062115
111MAP3K60.51104562
112CSNK2A10.50231614
113FES0.50208565
114RPS6KB10.49044886
115CSNK1D0.48171156
116CDK50.46811161
117NTRK10.46016688
118CAMK2D0.45063865
119INSRR0.43870558
120RPS6KA50.43665772
121PLK20.43635370
122TESK20.43557062
123ATM0.43433080
124GRK10.42955692
125MAP3K40.41809407
126NEK90.41332092
127PIM10.40900608
128CDK90.39614514
129PRKDC0.38964409
130RAF10.38403673
131BRAF0.38274872
132CSNK1E0.34946549
133AKT20.34039393
134CAMKK20.34025175
135TGFBR10.32711473
136CDK30.32199726
137MET0.32043002
138MARK30.31260512
139MAP2K60.31258478
140FGFR20.29952729
141STK100.29468323
142CSNK1A1L0.28577941

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.89280461
2Mismatch repair_Homo sapiens_hsa034303.36434237
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03788352
4RNA polymerase_Homo sapiens_hsa030203.02402358
5Ribosome_Homo sapiens_hsa030102.71437403
6Phototransduction_Homo sapiens_hsa047442.54583767
7Homologous recombination_Homo sapiens_hsa034402.34472944
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21993520
9Nucleotide excision repair_Homo sapiens_hsa034202.13369351
10Nicotine addiction_Homo sapiens_hsa050332.04302929
11Spliceosome_Homo sapiens_hsa030402.04121680
12RNA transport_Homo sapiens_hsa030131.92596661
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.82958559
14Cell cycle_Homo sapiens_hsa041101.79941102
15Proteasome_Homo sapiens_hsa030501.76267287
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.71040034
17Base excision repair_Homo sapiens_hsa034101.66227845
18Pyrimidine metabolism_Homo sapiens_hsa002401.65986073
19Fanconi anemia pathway_Homo sapiens_hsa034601.65742367
20Parkinsons disease_Homo sapiens_hsa050121.62783033
21Nitrogen metabolism_Homo sapiens_hsa009101.58541394
22Cardiac muscle contraction_Homo sapiens_hsa042601.50990860
23Oxidative phosphorylation_Homo sapiens_hsa001901.46754842
24RNA degradation_Homo sapiens_hsa030181.42774424
25Basal transcription factors_Homo sapiens_hsa030221.42300598
26Selenocompound metabolism_Homo sapiens_hsa004501.41901673
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38434354
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38303895
29Purine metabolism_Homo sapiens_hsa002301.38096959
30Non-homologous end-joining_Homo sapiens_hsa034501.35287044
31Fatty acid biosynthesis_Homo sapiens_hsa000611.30983652
32Oocyte meiosis_Homo sapiens_hsa041141.30530852
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28956199
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27002324
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25939633
36Sphingolipid metabolism_Homo sapiens_hsa006001.24479495
37Propanoate metabolism_Homo sapiens_hsa006401.21091709
38Pentose phosphate pathway_Homo sapiens_hsa000301.17660607
39Huntingtons disease_Homo sapiens_hsa050161.13707986
40Pyruvate metabolism_Homo sapiens_hsa006201.12908550
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12851616
42GABAergic synapse_Homo sapiens_hsa047271.09977114
43Glutamatergic synapse_Homo sapiens_hsa047241.09674944
44mRNA surveillance pathway_Homo sapiens_hsa030151.06791359
45One carbon pool by folate_Homo sapiens_hsa006701.04830086
46Carbon metabolism_Homo sapiens_hsa012001.04657490
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01308764
48Alzheimers disease_Homo sapiens_hsa050101.01291554
49Ether lipid metabolism_Homo sapiens_hsa005650.96236649
50Protein export_Homo sapiens_hsa030600.94825931
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93358011
52Mineral absorption_Homo sapiens_hsa049780.93057988
53Viral carcinogenesis_Homo sapiens_hsa052030.89688723
54MicroRNAs in cancer_Homo sapiens_hsa052060.89624672
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88502237
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87953252
57Long-term potentiation_Homo sapiens_hsa047200.87777231
58Circadian rhythm_Homo sapiens_hsa047100.87513120
59Alcoholism_Homo sapiens_hsa050340.86885211
60Synaptic vesicle cycle_Homo sapiens_hsa047210.86206407
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86105348
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85360538
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79095211
64N-Glycan biosynthesis_Homo sapiens_hsa005100.77658360
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76965371
66Thyroid cancer_Homo sapiens_hsa052160.76899640
67Steroid biosynthesis_Homo sapiens_hsa001000.76861116
68p53 signaling pathway_Homo sapiens_hsa041150.76737120
69Salivary secretion_Homo sapiens_hsa049700.75463846
70Vitamin B6 metabolism_Homo sapiens_hsa007500.74231508
71Circadian entrainment_Homo sapiens_hsa047130.73301344
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72185683
73Long-term depression_Homo sapiens_hsa047300.72170694
74Morphine addiction_Homo sapiens_hsa050320.71171023
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71045304
76Serotonergic synapse_Homo sapiens_hsa047260.70962833
77Hippo signaling pathway_Homo sapiens_hsa043900.69921157
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69553531
79Pancreatic secretion_Homo sapiens_hsa049720.69396809
80Gastric acid secretion_Homo sapiens_hsa049710.68966615
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68699435
82Fructose and mannose metabolism_Homo sapiens_hsa000510.67350118
83Colorectal cancer_Homo sapiens_hsa052100.66521511
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.66138702
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66129763
86Lysine degradation_Homo sapiens_hsa003100.65241097
87Dopaminergic synapse_Homo sapiens_hsa047280.64260706
88Adherens junction_Homo sapiens_hsa045200.64239639
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.63923590
90Basal cell carcinoma_Homo sapiens_hsa052170.61757497
91Amphetamine addiction_Homo sapiens_hsa050310.59486594
92Wnt signaling pathway_Homo sapiens_hsa043100.58357887
93Olfactory transduction_Homo sapiens_hsa047400.58173270
94Gap junction_Homo sapiens_hsa045400.57826654
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57804607
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51501710
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51375246
98Caffeine metabolism_Homo sapiens_hsa002320.49714886
99Folate biosynthesis_Homo sapiens_hsa007900.49616880
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49139674
101Insulin secretion_Homo sapiens_hsa049110.49128380
102Calcium signaling pathway_Homo sapiens_hsa040200.48707398
103Fatty acid metabolism_Homo sapiens_hsa012120.47669096
104Biosynthesis of amino acids_Homo sapiens_hsa012300.47570232
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47369236
106Hedgehog signaling pathway_Homo sapiens_hsa043400.47367127
107* Glycerophospholipid metabolism_Homo sapiens_hsa005640.44422217
108Prostate cancer_Homo sapiens_hsa052150.44272465
109Cholinergic synapse_Homo sapiens_hsa047250.42838732
110TGF-beta signaling pathway_Homo sapiens_hsa043500.42551786
111Cocaine addiction_Homo sapiens_hsa050300.42305868
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40353549
113Systemic lupus erythematosus_Homo sapiens_hsa053220.38208483
114Epstein-Barr virus infection_Homo sapiens_hsa051690.38081149
115Arachidonic acid metabolism_Homo sapiens_hsa005900.37836740
116Taste transduction_Homo sapiens_hsa047420.37751719
117Regulation of autophagy_Homo sapiens_hsa041400.36307839
118Chronic myeloid leukemia_Homo sapiens_hsa052200.35966119
119HTLV-I infection_Homo sapiens_hsa051660.35029203
120Fatty acid elongation_Homo sapiens_hsa000620.34912741
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34289842
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34144441
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33283767
124Small cell lung cancer_Homo sapiens_hsa052220.31378004
125Melanoma_Homo sapiens_hsa052180.30811774
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29882454
127Vitamin digestion and absorption_Homo sapiens_hsa049770.29795708
128* Metabolic pathways_Homo sapiens_hsa011000.29125185
129Endometrial cancer_Homo sapiens_hsa052130.28786210
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28691745
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28268707
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.28096073
133Arginine and proline metabolism_Homo sapiens_hsa003300.26914654
134Renin-angiotensin system_Homo sapiens_hsa046140.26619938
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26386728
136Thyroid hormone synthesis_Homo sapiens_hsa049180.25800352
137Linoleic acid metabolism_Homo sapiens_hsa005910.25778519
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24974986
139Sulfur relay system_Homo sapiens_hsa041220.24771948
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24178066
141cAMP signaling pathway_Homo sapiens_hsa040240.23369880
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23061227
143Lysosome_Homo sapiens_hsa041420.22517029
144Herpes simplex infection_Homo sapiens_hsa051680.22343701
145Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20910698
146Tight junction_Homo sapiens_hsa045300.20790438
147Pancreatic cancer_Homo sapiens_hsa052120.19026249
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17593760
149Glioma_Homo sapiens_hsa052140.14773621
150Bladder cancer_Homo sapiens_hsa052190.13206168
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10772585
152Pathways in cancer_Homo sapiens_hsa052000.07138894
153Inositol phosphate metabolism_Homo sapiens_hsa005620.07058115
154Butanoate metabolism_Homo sapiens_hsa006500.06110445
155ErbB signaling pathway_Homo sapiens_hsa040120.05862059
156Glutathione metabolism_Homo sapiens_hsa004800.04993653
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.04341603
158Proteoglycans in cancer_Homo sapiens_hsa052050.03905692

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