AGPS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.29883139
2nuclear pore organization (GO:0006999)4.94257044
3mitotic sister chromatid cohesion (GO:0007064)4.53175521
4ribosome assembly (GO:0042255)4.45341126
5protein localization to kinetochore (GO:0034501)4.35008540
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.28410917
7DNA unwinding involved in DNA replication (GO:0006268)4.15307224
8pore complex assembly (GO:0046931)4.13633801
9protein localization to chromosome, centromeric region (GO:0071459)3.88176322
10formation of translation preinitiation complex (GO:0001731)3.81937048
11mitotic chromosome condensation (GO:0007076)3.79083247
12regulation of sister chromatid cohesion (GO:0007063)3.70023907
13double-strand break repair via nonhomologous end joining (GO:0006303)3.69766022
14non-recombinational repair (GO:0000726)3.69766022
15mitotic nuclear envelope disassembly (GO:0007077)3.69282766
16positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.65190568
17positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.65190568
18positive regulation of mitotic sister chromatid separation (GO:1901970)3.65190568
19membrane disassembly (GO:0030397)3.54428775
20nuclear envelope disassembly (GO:0051081)3.54428775
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.50451317
22establishment of integrated proviral latency (GO:0075713)3.48127426
23regulation of RNA export from nucleus (GO:0046831)3.48074882
24very-low-density lipoprotein particle assembly (GO:0034379)3.47215772
25positive regulation of chromosome segregation (GO:0051984)3.45849522
26sister chromatid segregation (GO:0000819)3.43732235
27protein export from nucleus (GO:0006611)3.42552112
28regulation of DNA endoreduplication (GO:0032875)3.41125164
29pre-miRNA processing (GO:0031054)3.32098797
30regulation of spindle organization (GO:0090224)3.30786659
31IMP metabolic process (GO:0046040)3.29595385
32COPI coating of Golgi vesicle (GO:0048205)3.28371832
33Golgi transport vesicle coating (GO:0048200)3.28371832
34microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.23516655
35kinetochore organization (GO:0051383)3.22889256
36COPII vesicle coating (GO:0048208)3.21317197
37spindle assembly involved in mitosis (GO:0090307)3.20426925
38DNA geometric change (GO:0032392)3.20096605
39DNA duplex unwinding (GO:0032508)3.19617713
40attachment of spindle microtubules to kinetochore (GO:0008608)3.18455001
41IMP biosynthetic process (GO:0006188)3.17857828
42pinocytosis (GO:0006907)3.14877379
43hepatocyte apoptotic process (GO:0097284)3.11109184
44positive regulation of cell size (GO:0045793)3.10014328
45regulation of mitotic spindle organization (GO:0060236)3.05973291
46mitotic metaphase plate congression (GO:0007080)3.05055344
47mitotic sister chromatid segregation (GO:0000070)3.02590009
48dosage compensation (GO:0007549)3.02019194
49regulation of histone H3-K9 methylation (GO:0051570)3.00548371
50RNA stabilization (GO:0043489)3.00345827
51mRNA stabilization (GO:0048255)3.00345827
52cell adhesion mediated by integrin (GO:0033627)2.99904833
53positive regulation of SMAD protein import into nucleus (GO:0060391)2.98926406
54nuclear envelope organization (GO:0006998)2.98485378
55meiotic chromosome segregation (GO:0045132)2.98458764
56DNA replication-dependent nucleosome organization (GO:0034723)2.97517331
57DNA replication-dependent nucleosome assembly (GO:0006335)2.97517331
58protein localization to microtubule (GO:0035372)2.94100077
59monoubiquitinated protein deubiquitination (GO:0035520)2.93964531
60metaphase plate congression (GO:0051310)2.92736419
61nucleobase-containing small molecule interconversion (GO:0015949)2.91904105
62negative regulation of fibrinolysis (GO:0051918)2.88625741
63establishment of chromosome localization (GO:0051303)2.87950996
64chromatin assembly (GO:0031497)2.87937289
65DNA topological change (GO:0006265)2.85830170
66glucocorticoid receptor signaling pathway (GO:0042921)2.84625671
67regulation of centrosome cycle (GO:0046605)2.84381872
68histone monoubiquitination (GO:0010390)2.83825158
69protein localization to chromosome (GO:0034502)2.83303925
70glutamine metabolic process (GO:0006541)2.81659525
71heterochromatin organization (GO:0070828)2.80513133
72regulation of nucleobase-containing compound transport (GO:0032239)2.79320109
73regulation of centriole replication (GO:0046599)2.78861473
74regulation of apoptotic cell clearance (GO:2000425)2.78511081
75DNA replication initiation (GO:0006270)2.78399304
76embryonic process involved in female pregnancy (GO:0060136)2.77242808
77cellular protein complex localization (GO:0034629)2.76713889
78negative regulation of histone methylation (GO:0031061)2.76692849
79NLS-bearing protein import into nucleus (GO:0006607)2.75833485
80cellular hyperosmotic response (GO:0071474)2.74865307
81regulation of centrosome duplication (GO:0010824)2.72820094
82histone H2A monoubiquitination (GO:0035518)2.71000227
83negative regulation of DNA repair (GO:0045738)2.69246754
84translesion synthesis (GO:0019985)2.68207330
85histone-serine phosphorylation (GO:0035404)2.67977678
86DNA strand elongation involved in DNA replication (GO:0006271)2.67678758
87negative regulation of phagocytosis (GO:0050765)2.67324431
88plasma lipoprotein particle assembly (GO:0034377)2.64988194
89regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.63237297
90mitotic recombination (GO:0006312)2.62645508
91regulation of SMAD protein import into nucleus (GO:0060390)2.62346293
923-UTR-mediated mRNA stabilization (GO:0070935)2.61570869
93regulation of chromosome segregation (GO:0051983)2.59242855
94cytoplasmic mRNA processing body assembly (GO:0033962)2.58709792
95chromatin assembly or disassembly (GO:0006333)2.58205516
96histone H2B ubiquitination (GO:0033523)2.57986385
97corticosteroid receptor signaling pathway (GO:0031958)2.57531194
98proline biosynthetic process (GO:0006561)2.57515848
99DNA ligation (GO:0006266)2.57196382
100DNA conformation change (GO:0071103)2.57129640
101chromosome segregation (GO:0007059)2.56621090
102telomere maintenance via semi-conservative replication (GO:0032201)2.56377573
103neutrophil mediated immunity (GO:0002446)2.55901059
104V(D)J recombination (GO:0033151)2.55251183
105DNA strand elongation (GO:0022616)2.54554613
106DNA replication checkpoint (GO:0000076)2.54362348
107mRNA transport (GO:0051028)2.53696007
108purine nucleobase biosynthetic process (GO:0009113)2.53634770
109nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.53221463
110nucleotide-sugar biosynthetic process (GO:0009226)2.52334367
111regulation of translational termination (GO:0006449)2.51838968
112spindle checkpoint (GO:0031577)2.51259172
113folic acid-containing compound biosynthetic process (GO:0009396)2.50850519
114regulation of mitotic metaphase/anaphase transition (GO:0030071)2.50613053
115nucleobase biosynthetic process (GO:0046112)2.49420093
116vesicle coating (GO:0006901)2.49326126
117protein complex localization (GO:0031503)2.48335218
118protein-lipid complex assembly (GO:0065005)2.48090478
119positive regulation of cell cycle checkpoint (GO:1901978)2.46563570
120mitotic DNA integrity checkpoint (GO:0044774)2.44399650
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.44334526
122chromatin remodeling at centromere (GO:0031055)2.43558458
123DNA replication-independent nucleosome organization (GO:0034724)2.42879265
124DNA replication-independent nucleosome assembly (GO:0006336)2.42879265
125positive regulation of immune response to tumor cell (GO:0002839)2.42778981
126regulation of immune response to tumor cell (GO:0002837)2.42778981
127regulation of response to tumor cell (GO:0002834)2.42778981
128positive regulation of response to tumor cell (GO:0002836)2.42778981
129chromosome condensation (GO:0030261)2.41530069
130regulation of mRNA stability (GO:0043488)2.41442642
131DNA synthesis involved in DNA repair (GO:0000731)2.41437766
132negative regulation of B cell proliferation (GO:0030889)2.41117227
133positive regulation of histone H3-K4 methylation (GO:0051571)2.40877536
134definitive hemopoiesis (GO:0060216)2.40532587
135CENP-A containing nucleosome assembly (GO:0034080)2.40401015
136mitotic cytokinesis (GO:0000281)2.38933554
137mitotic spindle organization (GO:0007052)2.38633283
138spindle assembly (GO:0051225)2.38489801
139establishment of viral latency (GO:0019043)2.38043177
140protein localization to endosome (GO:0036010)2.37941198
141negative regulation of fibroblast apoptotic process (GO:2000270)2.37455827
142hippo signaling (GO:0035329)2.37315085
143regulation of protein export from nucleus (GO:0046825)2.37198575
144tetrahydrofolate metabolic process (GO:0046653)2.36903011
145regulation of translational fidelity (GO:0006450)2.35560638
146telomere maintenance via recombination (GO:0000722)2.34697370
147leukocyte aggregation (GO:0070486)2.34296039
148hepatocyte differentiation (GO:0070365)2.33336388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.24658304
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.41195619
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.86711346
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.53024957
5AR_21909140_ChIP-Seq_LNCAP_Human2.86051181
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.85192712
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83714132
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.64012655
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.54453504
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.41656790
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14460267
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.12321586
13* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05959914
14E2F7_22180533_ChIP-Seq_HELA_Human10.1846512
15ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93524077
16WT1_19549856_ChIP-ChIP_CCG9911_Human1.87031767
17MYC_22102868_ChIP-Seq_BL_Human1.86445288
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76349031
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74891077
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74411802
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65867314
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62397351
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60866006
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59145157
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53793642
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53228262
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52621567
28* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47533273
29* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47139754
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46790963
31VDR_21846776_ChIP-Seq_THP-1_Human1.45104167
32ELK1_19687146_ChIP-ChIP_HELA_Human1.44712782
33GATA1_22025678_ChIP-Seq_K562_Human1.44687591
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42738109
35ZNF263_19887448_ChIP-Seq_K562_Human1.42579811
36* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41793671
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40552210
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39357699
39* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36783368
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36745567
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.35867258
42DCP1A_22483619_ChIP-Seq_HELA_Human1.35289197
43TFEB_21752829_ChIP-Seq_HELA_Human1.34292739
44* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33999709
45* SPI1_23547873_ChIP-Seq_NB4_Human1.33582699
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33035088
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31529443
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31457833
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31079531
50* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27648143
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25623767
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25475436
53* IRF8_27001747_Chip-Seq_BMDM_Mouse1.25372973
54SOX17_20123909_ChIP-Seq_XEN_Mouse1.24390874
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24372776
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24336057
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22744084
58MYB_26560356_Chip-Seq_TH2_Human1.21865616
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21640967
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19472429
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19197144
62MYB_26560356_Chip-Seq_TH1_Human1.17560320
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14469634
64* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14352505
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12434553
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12380014
67* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11693818
68* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11177472
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10224400
70* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08732238
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08566779
72VDR_24763502_ChIP-Seq_THP-1_Human1.08440092
73* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08431469
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08422135
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07947415
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.07324070
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06912223
78CLOCK_20551151_ChIP-Seq_293T_Human1.06715606
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06469182
80* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06408287
81* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06408287
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06355038
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05587269
84KDM5A_27292631_Chip-Seq_BREAST_Human1.05461637
85TCF7_22412390_ChIP-Seq_EML_Mouse1.05452945
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05049296
87MAF_26560356_Chip-Seq_TH1_Human1.04761654
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04540640
89CHD1_26751641_Chip-Seq_LNCaP_Human1.04539260
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04253136
91EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04124110
92TTF2_22483619_ChIP-Seq_HELA_Human1.03436642
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02042400
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01905494
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01872585
96ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01388001
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01009393
98* RUNX1_22412390_ChIP-Seq_EML_Mouse1.00952823
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99439454
100GABP_17652178_ChIP-ChIP_JURKAT_Human0.99391094
101IRF8_22096565_ChIP-ChIP_GC-B_Human0.98172424
102NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98121678
103CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98084685
104BRD4_25478319_ChIP-Seq_HGPS_Human0.97478393
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95986030
106FOXP3_21729870_ChIP-Seq_TREG_Human0.95588653
107UTX_26944678_Chip-Seq_JUKART_Human0.95095765
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94832263
109SCL_19346495_ChIP-Seq_HPC-7_Human0.94680076
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93962066
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93898637
112PU_27001747_Chip-Seq_BMDM_Mouse0.93164532
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91944934
114PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91390394
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91025704
116VDR_23849224_ChIP-Seq_CD4+_Human0.90639252
117* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90370770
118NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89881523
119XRN2_22483619_ChIP-Seq_HELA_Human0.89570579
120* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87805336
121* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87138988
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87031134
123FOXO3_23340844_ChIP-Seq_DLD1_Human0.86681379
124SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86207373
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86058660
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84324267
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84256287
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.83386824
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83129403
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82610746
131CIITA_25753668_ChIP-Seq_RAJI_Human0.82579461
132GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82218750
133TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81766134
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81207756
135EWS_26573619_Chip-Seq_HEK293_Human0.80295126
136* TCF4_18268006_ChIP-ChIP_LS174T_Human0.79154247
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76498573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.15590399
2MP0010094_abnormal_chromosome_stability2.76433374
3MP0009697_abnormal_copulation2.72569689
4MP0003693_abnormal_embryo_hatching2.48374835
5MP0003111_abnormal_nucleus_morphology2.47629109
6MP0004957_abnormal_blastocyst_morpholog2.45369427
7MP0003077_abnormal_cell_cycle2.43753616
8MP0000569_abnormal_digit_pigmentation2.41089588
9MP0010307_abnormal_tumor_latency2.40940827
10MP0002396_abnormal_hematopoietic_system2.29670932
11MP0008057_abnormal_DNA_replication2.27114562
12MP0001661_extended_life_span2.20976741
13MP0005076_abnormal_cell_differentiation2.16825575
14MP0003300_gastrointestinal_ulcer2.14198500
15MP0006054_spinal_hemorrhage2.13182538
16MP0003705_abnormal_hypodermis_morpholog2.10374511
17MP0010234_abnormal_vibrissa_follicle2.03200105
18MP0004264_abnormal_extraembryonic_tissu2.00578134
19MP0002009_preneoplasia1.97022756
20MP0003566_abnormal_cell_adhesion1.89444367
21MP0008007_abnormal_cellular_replicative1.82907409
22MP0000350_abnormal_cell_proliferation1.79114859
23MP0001730_embryonic_growth_arrest1.79067583
24MP0002166_altered_tumor_susceptibility1.78910003
25MP0002877_abnormal_melanocyte_morpholog1.76138406
26MP0008438_abnormal_cutaneous_collagen1.74690420
27MP0003123_paternal_imprinting1.71191980
28MP0000013_abnormal_adipose_tissue1.68022699
29MP0003941_abnormal_skin_development1.65593864
30MP0003303_peritoneal_inflammation1.63911214
31MP0002139_abnormal_hepatobiliary_system1.63270967
32MP0004808_abnormal_hematopoietic_stem1.58333891
33MP0002006_tumorigenesis1.57194888
34MP0003121_genomic_imprinting1.55971338
35MP0001958_emphysema1.53383740
36MP0003984_embryonic_growth_retardation1.52933185
37MP0000733_abnormal_muscle_development1.52270905
38MP0003567_abnormal_fetal_cardiomyocyte1.50825390
39MP0001915_intracranial_hemorrhage1.50625515
40MP0002086_abnormal_extraembryonic_tissu1.50367442
41MP0002088_abnormal_embryonic_growth/wei1.50012202
42MP0001672_abnormal_embryogenesis/_devel1.49390561
43MP0005380_embryogenesis_phenotype1.49390561
44MP0001697_abnormal_embryo_size1.46940477
45MP0004197_abnormal_fetal_growth/weight/1.46809302
46MP0009053_abnormal_anal_canal1.45943212
47MP0008932_abnormal_embryonic_tissue1.41841395
48MP0002084_abnormal_developmental_patter1.41327071
49MP0000490_abnormal_crypts_of1.40151392
50MP0000537_abnormal_urethra_morphology1.37619407
51MP0001881_abnormal_mammary_gland1.34651053
52MP0003656_abnormal_erythrocyte_physiolo1.27593170
53MP0002085_abnormal_embryonic_tissue1.27401196
54MP0003448_altered_tumor_morphology1.23468207
55MP0003868_abnormal_feces_composition1.22985333
56MP0000858_altered_metastatic_potential1.21815918
57MP0005023_abnormal_wound_healing1.19479619
58MP0010678_abnormal_skin_adnexa1.19041894
59MP0002080_prenatal_lethality1.14735159
60MP0003436_decreased_susceptibility_to1.13440059
61MP0003950_abnormal_plasma_membrane1.13306338
62MP0003091_abnormal_cell_migration1.12561015
63MP0003252_abnormal_bile_duct1.11703342
64MP0003718_maternal_effect1.09209549
65MP0002138_abnormal_hepatobiliary_system1.08726358
66MP0005058_abnormal_lysosome_morphology1.07749300
67MP0005451_abnormal_body_composition1.05506914
68MP0002019_abnormal_tumor_incidence1.05429963
69MP0001666_abnormal_nutrient_absorption1.04266700
70MP0003806_abnormal_nucleotide_metabolis1.02496049
71MP0008877_abnormal_DNA_methylation1.00614548
72MP0003937_abnormal_limbs/digits/tail_de1.00269231
73MP0004233_abnormal_muscle_weight0.99565557
74MP0002925_abnormal_cardiovascular_devel0.98687177
75MP0000358_abnormal_cell_content/0.97553884
76MP0005220_abnormal_exocrine_pancreas0.97293304
77MP0003172_abnormal_lysosome_physiology0.97258766
78MP0000313_abnormal_cell_death0.97206332
79MP0002419_abnormal_innate_immunity0.96318655
80MP0009703_decreased_birth_body0.95204852
81MP0004185_abnormal_adipocyte_glucose0.94688103
82MP0009278_abnormal_bone_marrow0.91815653
83MP0000371_diluted_coat_color0.91730017
84MP0008058_abnormal_DNA_repair0.91623829
85MP0005397_hematopoietic_system_phenotyp0.91528899
86MP0001545_abnormal_hematopoietic_system0.91528899
87MP0003786_premature_aging0.90300634
88MP0003890_abnormal_embryonic-extraembry0.89789380
89MP0005623_abnormal_meninges_morphology0.89788644
90MP0002398_abnormal_bone_marrow0.88100205
91MP0005257_abnormal_intraocular_pressure0.87493214
92MP0004272_abnormal_basement_membrane0.87489587
93MP0000609_abnormal_liver_physiology0.85839323
94MP0001835_abnormal_antigen_presentation0.85388795
95MP0001293_anophthalmia0.84267756
96MP0009672_abnormal_birth_weight0.83969230
97MP0002452_abnormal_antigen_presenting0.83841886
98MP0000598_abnormal_liver_morphology0.83580021
99MP0000465_gastrointestinal_hemorrhage0.83451353
100MP0002697_abnormal_eye_size0.82615135
101MP0005365_abnormal_bile_salt0.82535187
102MP0005621_abnormal_cell_physiology0.82431152
103MP0000383_abnormal_hair_follicle0.82287296
104MP0003115_abnormal_respiratory_system0.81071792
105MP0000432_abnormal_head_morphology0.80971156
106MP0000428_abnormal_craniofacial_morphol0.80904668
107MP0002060_abnormal_skin_morphology0.80248276
108MP0005408_hypopigmentation0.80141340
109MP0000703_abnormal_thymus_morphology0.78117286
110MP0002092_abnormal_eye_morphology0.77282879
111MP0002722_abnormal_immune_system0.77237393
112MP0001819_abnormal_immune_cell0.77024521
113MP0003385_abnormal_body_wall0.76702420
114MP0002420_abnormal_adaptive_immunity0.76524420
115MP0004782_abnormal_surfactant_physiolog0.76039156
116MP0005085_abnormal_gallbladder_physiolo0.75889641
117MP0000627_abnormal_mammary_gland0.75704033
118MP0000477_abnormal_intestine_morphology0.75360867
119MP0005384_cellular_phenotype0.75299132
120MP0003943_abnormal_hepatobiliary_system0.73863498
121MP0000747_muscle_weakness0.73564267
122MP0004134_abnormal_chest_morphology0.73226005
123MP0000377_abnormal_hair_follicle0.72722025
124MP0000689_abnormal_spleen_morphology0.72578788
125MP0003283_abnormal_digestive_organ0.71260537
126MP0003221_abnormal_cardiomyocyte_apopto0.71233927
127MP0001849_ear_inflammation0.70760795
128MP0010630_abnormal_cardiac_muscle0.70527478
129MP0005409_darkened_coat_color0.70505483
130MP0000003_abnormal_adipose_tissue0.70272496
131MP0004147_increased_porphyrin_level0.69885749
132MP0003315_abnormal_perineum_morphology0.69815892
133MP0002429_abnormal_blood_cell0.68926286
134MP0000716_abnormal_immune_system0.68906883
135MP0000516_abnormal_urinary_system0.68811128
136MP0005367_renal/urinary_system_phenotyp0.68811128
137MP0002269_muscular_atrophy0.68732673
138MP0003453_abnormal_keratinocyte_physiol0.68409968
139MP0001216_abnormal_epidermal_layer0.67720959
140MP0005330_cardiomyopathy0.66474851
141MP0002896_abnormal_bone_mineralization0.65644235

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of oral frenula (HP:0000190)3.31899537
2Premature rupture of membranes (HP:0001788)3.27549742
3Submucous cleft hard palate (HP:0000176)3.27062013
4Multiple enchondromatosis (HP:0005701)3.25774511
5Termporal pattern (HP:0011008)3.23609628
6Insidious onset (HP:0003587)3.23609628
7Fatigue (HP:0012378)3.21142262
8Overlapping toe (HP:0001845)3.06828689
9Short 4th metacarpal (HP:0010044)2.88685488
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.88685488
11Hypobetalipoproteinemia (HP:0003563)2.85275014
12Volvulus (HP:0002580)2.84871544
13Myocardial infarction (HP:0001658)2.80917327
14Syringomyelia (HP:0003396)2.80581285
15Spinal cord lesions (HP:0100561)2.80581285
16Flat acetabular roof (HP:0003180)2.76964562
17Abnormality of the common coagulation pathway (HP:0010990)2.70731560
18Agnosia (HP:0010524)2.65106470
19Deep venous thrombosis (HP:0002625)2.60768839
20Missing ribs (HP:0000921)2.59625147
21Papilledema (HP:0001085)2.58884531
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.57228383
23Osteolytic defects of the hand bones (HP:0009699)2.57228383
2411 pairs of ribs (HP:0000878)2.54192827
25Shallow orbits (HP:0000586)2.52943638
26Back pain (HP:0003418)2.52628369
27Thrombocytosis (HP:0001894)2.49564518
28Short nail (HP:0001799)2.43282898
29Abnormal foot bone ossification (HP:0010675)2.41055995
30Increased density of long bones (HP:0006392)2.40541087
31Abnormality of the fingertips (HP:0001211)2.40386654
32Orthostatic hypotension (HP:0001278)2.39924343
33Recurrent abscess formation (HP:0002722)2.39823735
34Cervical subluxation (HP:0003308)2.39807173
35Deviation of the thumb (HP:0009603)2.38454717
36Disinhibition (HP:0000734)2.37212382
37Broad palm (HP:0001169)2.37097893
38Subacute progressive viral hepatitis (HP:0006572)2.34736923
39Chromsome breakage (HP:0040012)2.33167471
40Cutaneous melanoma (HP:0012056)2.33097950
41Nephroblastoma (Wilms tumor) (HP:0002667)2.32943845
42Relative macrocephaly (HP:0004482)2.30485203
43Persistence of primary teeth (HP:0006335)2.28874163
44Uterine leiomyosarcoma (HP:0002891)2.25867783
45Leiomyosarcoma (HP:0100243)2.25867783
46Arterial tortuosity (HP:0005116)2.24111010
47Colon cancer (HP:0003003)2.23907723
48Embryonal renal neoplasm (HP:0011794)2.23577290
49Hematochezia (HP:0002573)2.22298798
50High pitched voice (HP:0001620)2.22081216
51Scanning speech (HP:0002168)2.21760290
52Thyroid carcinoma (HP:0002890)2.20530599
53Eczematoid dermatitis (HP:0000976)2.19334605
54Abnormality of chromosome stability (HP:0003220)2.18710989
55Proximal placement of thumb (HP:0009623)2.17666970
56Acute myeloid leukemia (HP:0004808)2.17508271
57Biliary tract neoplasm (HP:0100574)2.17309277
58Recurrent bacterial skin infections (HP:0005406)2.15538724
59Increased nuchal translucency (HP:0010880)2.14025228
60Abnormal cartilage morphology (HP:0002763)2.13622602
61Ectopic kidney (HP:0000086)2.13593809
62Absent frontal sinuses (HP:0002688)2.12827260
63Neoplasm of the rectum (HP:0100743)2.10616396
64Cerebral aneurysm (HP:0004944)2.09601766
65Facial hemangioma (HP:0000329)2.05490335
66Dysmetric saccades (HP:0000641)2.05028184
67Malignant gastrointestinal tract tumors (HP:0006749)2.03155435
68Gastrointestinal carcinoma (HP:0002672)2.03155435
69Tetraparesis (HP:0002273)2.01514360
70Deep philtrum (HP:0002002)2.00336625
71Ependymoma (HP:0002888)2.00239713
72Amaurosis fugax (HP:0100576)2.00099848
73Heterotopia (HP:0002282)1.99465572
74Abnormality of pain sensation (HP:0010832)1.97990142
75Impaired pain sensation (HP:0007328)1.97990142
76Ureteral obstruction (HP:0006000)1.97206947
77Rhabdomyosarcoma (HP:0002859)1.93813369
78Metaphyseal cupping (HP:0003021)1.93672533
79Abnormality of carpal bone ossification (HP:0006257)1.93526896
80Conjugated hyperbilirubinemia (HP:0002908)1.93525805
81Acute lymphatic leukemia (HP:0006721)1.93490174
82Hepatocellular carcinoma (HP:0001402)1.91568509
83Ureteral stenosis (HP:0000071)1.90918288
84Menstrual irregularities (HP:0000858)1.90777476
85Pancreatic islet-cell hyperplasia (HP:0004510)1.89265684
86Astrocytoma (HP:0009592)1.89082304
87Abnormality of the astrocytes (HP:0100707)1.89082304
88Spondylolisthesis (HP:0003302)1.88865570
89Selective tooth agenesis (HP:0001592)1.88354176
90Spinal muscular atrophy (HP:0007269)1.88150564
91Acanthocytosis (HP:0001927)1.85638749
92Abnormality of the intrinsic pathway (HP:0010989)1.85276461
93Entropion (HP:0000621)1.83196153
94Abnormality of the peritoneum (HP:0002585)1.82243335
95Abnormality of the calcaneus (HP:0008364)1.81207575
96Stillbirth (HP:0003826)1.80402112
97Narrow palate (HP:0000189)1.80054323
98Pseudobulbar signs (HP:0002200)1.79822716
99Abnormality of the lumbar spine (HP:0100712)1.79711567
100Dilatation of the ascending aorta (HP:0005111)1.79356503
101Glucose intolerance (HP:0000833)1.78877499
102Birth length less than 3rd percentile (HP:0003561)1.78742181
103Vascular tortuosity (HP:0004948)1.78562264
104Hypolipoproteinemia (HP:0010981)1.78489101
105Coarse hair (HP:0002208)1.78298763
106Abnormality of the 4th metacarpal (HP:0010012)1.78018678
107Sandal gap (HP:0001852)1.77846640
108Ascites (HP:0001541)1.76982216
109Uterine neoplasm (HP:0010784)1.76672878
110Abnormal delivery (HP:0001787)1.76388692
111Dislocated radial head (HP:0003083)1.76141944
112Cutis marmorata (HP:0000965)1.75824931
113Asymmetry of the thorax (HP:0001555)1.75765827
114Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75487686
115Hypercholesterolemia (HP:0003124)1.75298190
116Trismus (HP:0000211)1.74830982
117Cystic hygroma (HP:0000476)1.74541446
118Abnormality of glycolysis (HP:0004366)1.74191897
119Combined immunodeficiency (HP:0005387)1.73687205
120Neoplasm of the oral cavity (HP:0100649)1.73271479
121Increased serum pyruvate (HP:0003542)1.73172390
122Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73114125
123Medulloblastoma (HP:0002885)1.72308935
124Chronic obstructive pulmonary disease (HP:0006510)1.72153044
125Obstructive lung disease (HP:0006536)1.72153044
126Abnormality of the umbilical cord (HP:0010881)1.71656899
127Thin bony cortex (HP:0002753)1.71618585
128Abnormality of chloride homeostasis (HP:0011422)1.71605240
129Osteomyelitis (HP:0002754)1.71518026
130Myelodysplasia (HP:0002863)1.71033082
131Cupped ribs (HP:0000887)1.70696530
132Progressive external ophthalmoplegia (HP:0000590)1.70221843
133Transitional cell carcinoma of the bladder (HP:0006740)1.69699149
134Abnormalities of placenta or umbilical cord (HP:0001194)1.68921339
135Interstitial pulmonary disease (HP:0006530)1.68921025
136Cortical dysplasia (HP:0002539)1.67285736
137Long eyelashes (HP:0000527)1.67137551
138Trigonocephaly (HP:0000243)1.67029598
139Prominent nose (HP:0000448)1.66622379
140Ankle contracture (HP:0006466)1.66525462
141Intrahepatic cholestasis (HP:0001406)1.66474795
142Cellulitis (HP:0100658)1.66364227
143Rectal prolapse (HP:0002035)1.66101575
144Protrusio acetabuli (HP:0003179)1.65301693
145Prolonged partial thromboplastin time (HP:0003645)1.64927349
146Blepharitis (HP:0000498)1.64517883
147Ovarian neoplasm (HP:0100615)1.62820158
148Abnormality of the labia minora (HP:0012880)1.62439631
149Abnormality of macrophages (HP:0004311)1.61267412
150Metaphyseal dysplasia (HP:0100255)1.61098513
151IgM deficiency (HP:0002850)1.59752430
152Ulnar bowing (HP:0003031)1.59205307
153Bladder carcinoma (HP:0002862)1.57762250
154Bladder neoplasm (HP:0009725)1.57762250
155Abnormality of the anterior horn cell (HP:0006802)1.57168280
156Degeneration of anterior horn cells (HP:0002398)1.57168280
157Recurrent viral infections (HP:0004429)1.56973130
158Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.56626726
159Low anterior hairline (HP:0000294)1.56340150
160Neoplasm of the small intestine (HP:0100833)1.56221187
161Skull defect (HP:0001362)1.55216484
162Autoimmune thrombocytopenia (HP:0001973)1.54276530
163Broad thumb (HP:0011304)1.53968127
164Basal cell carcinoma (HP:0002671)1.53840572
165Papillary thyroid carcinoma (HP:0002895)1.53249927
166Flared metaphyses (HP:0003015)1.52395672
167Delayed closure of the anterior fontanelle (HP:0001476)1.52012898
168Eosinophilia (HP:0001880)1.52001323
169Ankyloglossia (HP:0010296)1.51444195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.59895547
2PBK3.16273805
3EIF2AK33.00262695
4CDK122.84490229
5STK102.40392230
6SCYL22.39880456
7PKN22.29731011
8LATS12.11445335
9MST1R2.08181969
10NEK22.06614160
11CDK62.02264811
12PAK41.99804579
13WEE11.94968526
14TTN1.83560552
15TTK1.75115028
16STK31.74637751
17EPHA21.70390938
18EEF2K1.68691974
19CAMK1D1.68580038
20MKNK11.60454861
21RPS6KA41.58172135
22LRRK21.56615250
23MAP3K81.55060367
24BRSK21.52688783
25NEK11.51885159
26ERBB41.48487505
27PLK31.48264224
28TRPM71.45334296
29MAP3K141.45289427
30EPHB11.44448736
31RPS6KB21.42168922
32NEK91.39648507
33CHEK21.38020185
34ERBB31.37315500
35TESK11.36244830
36PASK1.34698517
37SRPK11.33300291
38ATR1.28232103
39STK41.25326095
40CDK41.25154325
41WNK31.20255376
42LIMK11.19071550
43AURKB1.18849222
44IRAK31.14823691
45STK241.13072620
46PTK61.11108136
47CHEK11.10842164
48ALK1.09982524
49CAMK1G1.09830540
50ACVR1B1.09198330
51FRK1.08729485
52MAP3K21.08511497
53CDK71.03790307
54BCR1.02398932
55FLT31.01957956
56EIF2AK11.00465502
57TGFBR10.99072505
58BUB10.98963129
59PIM10.98104373
60FGFR20.98103694
61PLK10.97934673
62FGFR40.97731432
63MELK0.97209247
64MAP2K30.94451625
65ATM0.93999218
66ZAK0.93210850
67MAP3K100.92548751
68BMX0.91473825
69FGFR10.90582516
70TGFBR20.89285154
71ICK0.84999594
72TESK20.84719829
73MAP3K60.81896318
74MTOR0.80855985
75TSSK60.80756236
76IRAK40.80385513
77CLK10.80174228
78PLK20.79698851
79DMPK0.77780760
80KSR20.77525129
81MAPK110.77102242
82OXSR10.76964459
83BRD40.75935994
84PDGFRB0.75610236
85FGFR30.73748053
86CSF1R0.72674303
87PDK20.72140569
88PLK40.70869411
89CDK90.70327195
90PDGFRA0.69297859
91NME20.69234477
92CDK20.68626992
93MET0.68485442
94PAK20.68032982
95MST40.65776483
96TEC0.65351028
97WNK40.64808060
98STK38L0.64316231
99CCNB10.61954176
100YES10.60546589
101KSR10.59619038
102TRIB30.56258233
103BMPR20.56191809
104BTK0.56035369
105WNK10.55952149
106SGK30.53591250
107ITK0.51631738
108PTK20.51607528
109CSNK1D0.51032463
110MAP3K120.51011237
111EIF2AK20.50408498
112CDK10.50108037
113JAK30.47931034
114RPS6KB10.47083995
115TLK10.46724128
116STK390.46184958
117MKNK20.45003089
118RPS6KA50.44968860
119GSK3A0.44283901
120MAP4K10.44122341
121SGK20.43367436
122EGFR0.43116324
123CSK0.42175376
124DYRK30.41701749
125ZAP700.41439516
126LATS20.39548634
127RAF10.39089939
128TRIM280.36665913
129CSNK2A20.36557778
130CSNK1E0.32424712
131MAP2K10.29793287
132AURKA0.29548511
133PRKCH0.28970999
134PRPF4B0.28461061

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.72328567
2Cell cycle_Homo sapiens_hsa041102.58099902
3Mismatch repair_Homo sapiens_hsa034302.30844018
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.23219341
5RNA transport_Homo sapiens_hsa030131.98673042
6MicroRNAs in cancer_Homo sapiens_hsa052061.85861107
7Biosynthesis of amino acids_Homo sapiens_hsa012301.85372514
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.79245513
9Small cell lung cancer_Homo sapiens_hsa052221.73739102
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.69910054
11One carbon pool by folate_Homo sapiens_hsa006701.69892399
12Cysteine and methionine metabolism_Homo sapiens_hsa002701.64133457
13Leishmaniasis_Homo sapiens_hsa051401.62626357
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62260235
15Non-homologous end-joining_Homo sapiens_hsa034501.61558163
16Chronic myeloid leukemia_Homo sapiens_hsa052201.61375386
17Fatty acid biosynthesis_Homo sapiens_hsa000611.59610237
18Viral carcinogenesis_Homo sapiens_hsa052031.58860251
19Systemic lupus erythematosus_Homo sapiens_hsa053221.57052946
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.56818461
21Adherens junction_Homo sapiens_hsa045201.53699208
22p53 signaling pathway_Homo sapiens_hsa041151.52173528
23Pancreatic cancer_Homo sapiens_hsa052121.49244609
24Caffeine metabolism_Homo sapiens_hsa002321.49060389
25Base excision repair_Homo sapiens_hsa034101.48201463
26Spliceosome_Homo sapiens_hsa030401.47932342
27Homologous recombination_Homo sapiens_hsa034401.47406253
28Carbon metabolism_Homo sapiens_hsa012001.46664964
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46388783
30Nucleotide excision repair_Homo sapiens_hsa034201.42813242
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38624787
32Antigen processing and presentation_Homo sapiens_hsa046121.37305838
33Steroid biosynthesis_Homo sapiens_hsa001001.35310717
34mRNA surveillance pathway_Homo sapiens_hsa030151.34218763
35Viral myocarditis_Homo sapiens_hsa054161.34156481
36Proteasome_Homo sapiens_hsa030501.33374224
37Selenocompound metabolism_Homo sapiens_hsa004501.32420701
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32118513
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31339028
40Shigellosis_Homo sapiens_hsa051311.30343240
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26991420
42Proteoglycans in cancer_Homo sapiens_hsa052051.24115984
43Fanconi anemia pathway_Homo sapiens_hsa034601.22512287
44RNA degradation_Homo sapiens_hsa030181.22279808
45Pyruvate metabolism_Homo sapiens_hsa006201.17928828
46Colorectal cancer_Homo sapiens_hsa052101.17189148
47HTLV-I infection_Homo sapiens_hsa051661.16301219
48Pentose phosphate pathway_Homo sapiens_hsa000301.13738965
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13115056
50Complement and coagulation cascades_Homo sapiens_hsa046101.12625336
51Focal adhesion_Homo sapiens_hsa045101.11226767
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10279271
53Toxoplasmosis_Homo sapiens_hsa051451.09628503
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09012955
55Non-small cell lung cancer_Homo sapiens_hsa052231.08544789
56TGF-beta signaling pathway_Homo sapiens_hsa043501.08451532
57Herpes simplex infection_Homo sapiens_hsa051681.07660600
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07365712
59Thyroid cancer_Homo sapiens_hsa052161.07173108
60Legionellosis_Homo sapiens_hsa051341.06609068
61Vitamin B6 metabolism_Homo sapiens_hsa007501.05505055
62Hepatitis B_Homo sapiens_hsa051611.04201452
63Arginine biosynthesis_Homo sapiens_hsa002201.02950277
64Prostate cancer_Homo sapiens_hsa052151.02226276
65Galactose metabolism_Homo sapiens_hsa000521.01946134
66Renal cell carcinoma_Homo sapiens_hsa052111.01412657
67Hippo signaling pathway_Homo sapiens_hsa043901.01249120
68Osteoclast differentiation_Homo sapiens_hsa043801.00033610
69Apoptosis_Homo sapiens_hsa042100.98683112
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.98286738
71Lysine degradation_Homo sapiens_hsa003100.98141306
72Salmonella infection_Homo sapiens_hsa051320.98090924
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98036932
74Propanoate metabolism_Homo sapiens_hsa006400.97488664
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96871976
76Bladder cancer_Homo sapiens_hsa052190.95681091
77N-Glycan biosynthesis_Homo sapiens_hsa005100.95077468
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93722214
79B cell receptor signaling pathway_Homo sapiens_hsa046620.91824691
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91219401
81mTOR signaling pathway_Homo sapiens_hsa041500.89989137
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.88919893
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88894603
84Renin-angiotensin system_Homo sapiens_hsa046140.88343309
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87919160
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87695460
87Endometrial cancer_Homo sapiens_hsa052130.87162799
88Epstein-Barr virus infection_Homo sapiens_hsa051690.86846376
89ECM-receptor interaction_Homo sapiens_hsa045120.84190515
90Tuberculosis_Homo sapiens_hsa051520.82966132
91Platelet activation_Homo sapiens_hsa046110.82892165
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.81855009
93Pathways in cancer_Homo sapiens_hsa052000.81656314
94Lysosome_Homo sapiens_hsa041420.81215875
95Other glycan degradation_Homo sapiens_hsa005110.80782560
96Fatty acid metabolism_Homo sapiens_hsa012120.79379963
97Sulfur metabolism_Homo sapiens_hsa009200.77621095
98Measles_Homo sapiens_hsa051620.77061083
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76069464
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.75320856
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74957410
102Tight junction_Homo sapiens_hsa045300.72583492
103Influenza A_Homo sapiens_hsa051640.71953964
104Oocyte meiosis_Homo sapiens_hsa041140.71554717
105Phagosome_Homo sapiens_hsa041450.71311137
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71205388
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70926761
108Glioma_Homo sapiens_hsa052140.70896615
109Melanoma_Homo sapiens_hsa052180.70381735
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70032622
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69691435
112Pertussis_Homo sapiens_hsa051330.69626937
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68684437
114Amoebiasis_Homo sapiens_hsa051460.68045766
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.67283078
116Basal transcription factors_Homo sapiens_hsa030220.65718979
117TNF signaling pathway_Homo sapiens_hsa046680.65588420
118Starch and sucrose metabolism_Homo sapiens_hsa005000.65346723
119HIF-1 signaling pathway_Homo sapiens_hsa040660.65167655
120Prolactin signaling pathway_Homo sapiens_hsa049170.65067579
121Chemokine signaling pathway_Homo sapiens_hsa040620.64558977
122FoxO signaling pathway_Homo sapiens_hsa040680.63702185
123Protein export_Homo sapiens_hsa030600.60250161
124Hematopoietic cell lineage_Homo sapiens_hsa046400.59664369
125Fatty acid degradation_Homo sapiens_hsa000710.59659050
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58906633
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58545594
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58485972
129Acute myeloid leukemia_Homo sapiens_hsa052210.58426016
130VEGF signaling pathway_Homo sapiens_hsa043700.57028909
131Malaria_Homo sapiens_hsa051440.55463033
132Endocytosis_Homo sapiens_hsa041440.53111491
133Alcoholism_Homo sapiens_hsa050340.52998679
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52933552
135Notch signaling pathway_Homo sapiens_hsa043300.52727259
136Fructose and mannose metabolism_Homo sapiens_hsa000510.50527022
137Pyrimidine metabolism_Homo sapiens_hsa002400.48362486
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46998787
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.43817160
140Fat digestion and absorption_Homo sapiens_hsa049750.40647639
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38619491
142PPAR signaling pathway_Homo sapiens_hsa033200.37073948
143ErbB signaling pathway_Homo sapiens_hsa040120.35687377
144Insulin signaling pathway_Homo sapiens_hsa049100.34850029
145Arginine and proline metabolism_Homo sapiens_hsa003300.32704835

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »