AGR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)8.65757152
2maintenance of gastrointestinal epithelium (GO:0030277)8.41904621
3UDP-N-acetylglucosamine metabolic process (GO:0006047)8.35198947
4primary alcohol catabolic process (GO:0034310)7.23880409
5axonemal dynein complex assembly (GO:0070286)7.02133562
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.33736258
7epithelial structure maintenance (GO:0010669)6.29565497
8negative regulation of transcription by competitive promoter binding (GO:0010944)6.27249393
9fucose catabolic process (GO:0019317)6.00589364
10L-fucose metabolic process (GO:0042354)6.00589364
11L-fucose catabolic process (GO:0042355)6.00589364
12O-glycan processing (GO:0016266)5.85344020
13branching involved in prostate gland morphogenesis (GO:0060442)5.85231312
14negative regulation of digestive system process (GO:0060457)5.65288687
15calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.47009672
16intestinal absorption (GO:0050892)5.31148268
17cilium or flagellum-dependent cell motility (GO:0001539)5.26580993
18sulfation (GO:0051923)5.16720508
19nucleotide-sugar biosynthetic process (GO:0009226)5.14273306
20hepatocyte apoptotic process (GO:0097284)4.99642965
21bile acid and bile salt transport (GO:0015721)4.96079509
22negative regulation of epidermal cell differentiation (GO:0045605)4.95465833
23pyrimidine-containing compound transmembrane transport (GO:0072531)4.94908993
24galactose catabolic process (GO:0019388)4.88939746
25prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.82447085
26nucleotide-sugar metabolic process (GO:0009225)4.81901105
27diterpenoid biosynthetic process (GO:0016102)4.79820033
28sulfur amino acid catabolic process (GO:0000098)4.74248144
29digestive system process (GO:0022600)4.63655691
30galactose metabolic process (GO:0006012)4.60978949
31motile cilium assembly (GO:0044458)4.60730347
32fucose metabolic process (GO:0006004)4.60519196
33polyketide metabolic process (GO:0030638)4.58896172
34doxorubicin metabolic process (GO:0044598)4.58896172
35daunorubicin metabolic process (GO:0044597)4.58896172
363-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.56496925
37purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.56496925
38cilium movement (GO:0003341)4.44683238
39regulation of keratinocyte differentiation (GO:0045616)4.41389807
40oligosaccharide biosynthetic process (GO:0009312)4.41343609
41GDP-mannose metabolic process (GO:0019673)4.26763163
42glucuronate metabolic process (GO:0019585)4.16500064
43uronic acid metabolic process (GO:0006063)4.16500064
44cellular glucuronidation (GO:0052695)4.11277428
45aminoglycoside antibiotic metabolic process (GO:0030647)4.02975091
46Golgi transport vesicle coating (GO:0048200)4.01235372
47COPI coating of Golgi vesicle (GO:0048205)4.01235372
48detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.96979458
49receptor guanylyl cyclase signaling pathway (GO:0007168)3.93517069
50primary alcohol metabolic process (GO:0034308)3.89344237
51angiotensin maturation (GO:0002003)3.83033815
52protein O-linked glycosylation (GO:0006493)3.82221908
53phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.80075213
54digestion (GO:0007586)3.73195586
55transcytosis (GO:0045056)3.71883911
56negative regulation of epidermis development (GO:0045683)3.70506137
57protein autoprocessing (GO:0016540)3.67656756
58phosphatidylserine acyl-chain remodeling (GO:0036150)3.64901851
59progesterone metabolic process (GO:0042448)3.64799452
60nucleotide transmembrane transport (GO:1901679)3.64667187
61hormone catabolic process (GO:0042447)3.63895655
62desmosome organization (GO:0002934)3.62579398
63positive regulation of translational initiation (GO:0045948)3.61988590
64actin filament depolymerization (GO:0030042)3.61760497
65regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.56928201
66flavonoid metabolic process (GO:0009812)3.55463895
67epithelial cilium movement (GO:0003351)3.55456355
68retinal metabolic process (GO:0042574)3.53967368
69phosphatidylserine metabolic process (GO:0006658)3.52723018
70multicellular organismal water homeostasis (GO:0050891)3.51692237
71sulfate transmembrane transport (GO:1902358)3.51598442
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.51500748
73N-glycan processing (GO:0006491)3.51078185
74regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.50054051
75NADH metabolic process (GO:0006734)3.49177239
76prostate gland epithelium morphogenesis (GO:0060740)3.49135063
77positive regulation of pseudopodium assembly (GO:0031274)3.45763368
78artery development (GO:0060840)3.44832674
79epoxygenase P450 pathway (GO:0019373)3.39230458
80vitamin transmembrane transport (GO:0035461)3.39093402
81positive regulation of respiratory burst (GO:0060267)3.38357238
82glycoside metabolic process (GO:0016137)3.36938726
83maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.35606769
84regulation of chemokine secretion (GO:0090196)3.32044993
85hexose catabolic process (GO:0019320)3.31827217
86glutathione derivative metabolic process (GO:1901685)3.30660813
87glutathione derivative biosynthetic process (GO:1901687)3.30660813
88epithelial cell differentiation involved in prostate gland development (GO:0060742)3.29348315
89renal absorption (GO:0070293)3.29272108
90retinol metabolic process (GO:0042572)3.28279478
91ethanol metabolic process (GO:0006067)3.28274544
92glomerular filtration (GO:0003094)3.27567469
93hemidesmosome assembly (GO:0031581)3.27217197
94epithelial cell maturation (GO:0002070)3.26798569
95tight junction assembly (GO:0070830)3.25903448
96regulation of guanylate cyclase activity (GO:0031282)3.25421324
97regulation of vitamin metabolic process (GO:0030656)3.24186943
98regulation of keratinocyte proliferation (GO:0010837)3.22219205
99terpenoid biosynthetic process (GO:0016114)3.21746701
100columnar/cuboidal epithelial cell development (GO:0002066)3.18484909
101negative regulation of cell fate commitment (GO:0010454)3.14550551
102xenobiotic catabolic process (GO:0042178)3.13432562
103sulfur compound transport (GO:0072348)3.12702639
104regulation of cellular extravasation (GO:0002691)3.11442717
105renal filtration (GO:0097205)3.10203957
106positive regulation of Cdc42 GTPase activity (GO:0043089)3.09635023
107regulation of pH (GO:0006885)3.09541291
108regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.09029217
109low-density lipoprotein particle remodeling (GO:0034374)3.06713007
110antibacterial humoral response (GO:0019731)3.05894162
111ventricular cardiac muscle cell action potential (GO:0086005)3.05819965
112morphogenesis of an epithelial fold (GO:0060571)3.05474402
113regulation of pseudopodium assembly (GO:0031272)3.05056176
114regulation of viral entry into host cell (GO:0046596)3.04313152
115L-serine transport (GO:0015825)3.02695181
116negative regulation of keratinocyte proliferation (GO:0010839)3.00220246
117* lung secretory cell differentiation (GO:0061140)2.99578088
118hypotonic response (GO:0006971)2.99109217
119regulation of necrotic cell death (GO:0010939)2.98950823
120sphingomyelin metabolic process (GO:0006684)2.98663876
121* glandular epithelial cell differentiation (GO:0002067)2.97800215
122phosphatidylinositol acyl-chain remodeling (GO:0036149)2.97745211
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.96790224
124regulation of respiratory burst (GO:0060263)2.95952284
125cyclooxygenase pathway (GO:0019371)2.95850096
126positive regulation of actin filament depolymerization (GO:0030836)2.93734593
127antimicrobial humoral response (GO:0019730)2.93555818
128one-carbon compound transport (GO:0019755)2.89932997
129water homeostasis (GO:0030104)2.89877109
130branching involved in mammary gland duct morphogenesis (GO:0060444)2.89685086
131hydrogen peroxide catabolic process (GO:0042744)2.89457809
132protein retention in ER lumen (GO:0006621)2.86698614
133negative regulation of necroptotic process (GO:0060546)2.86675288
134glutathione biosynthetic process (GO:0006750)2.85775219
135alditol phosphate metabolic process (GO:0052646)2.84425827
136amino sugar metabolic process (GO:0006040)2.83865470
137monosaccharide catabolic process (GO:0046365)2.83835321
138excretion (GO:0007588)2.83288999
139retinoic acid metabolic process (GO:0042573)2.82861402
140sodium ion homeostasis (GO:0055078)2.82622904
141barbed-end actin filament capping (GO:0051016)2.82021922
142mannose metabolic process (GO:0006013)2.80792921
143epithelial cell-cell adhesion (GO:0090136)2.79108363
144sulfate transport (GO:0008272)2.78569044
145negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.77948414
146regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.77820684
147ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.77355484
148heart trabecula formation (GO:0060347)2.76773669
149regulation of necroptotic process (GO:0060544)2.76063120
150cellular response to cadmium ion (GO:0071276)2.74617065
151regulation of epidermal cell differentiation (GO:0045604)2.74349556
152thrombin receptor signaling pathway (GO:0070493)2.73904914
153positive regulation of glycoprotein metabolic process (GO:1903020)2.73902548
154fucosylation (GO:0036065)2.73274856
155cellular aldehyde metabolic process (GO:0006081)2.73091886
156amyloid precursor protein catabolic process (GO:0042987)2.71515531
157nucleoside diphosphate biosynthetic process (GO:0009133)2.71366371
158negative regulation of epithelial to mesenchymal transition (GO:0010719)2.70210680
159phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.69175063
160potassium ion homeostasis (GO:0055075)2.68355227
161cardiac conduction (GO:0061337)2.67958018
162thyroid hormone metabolic process (GO:0042403)2.65142687
163mucosal immune response (GO:0002385)2.64617466
164phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.63288317
165ethanol oxidation (GO:0006069)2.62886359
166mitochondrial calcium ion transport (GO:0006851)2.62424123
167positive regulation of steroid hormone secretion (GO:2000833)2.60522258

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.66541013
2* SOX2_27498859_Chip-Seq_STOMACH_Mouse4.44725776
3CDX2_20551321_ChIP-Seq_CACO-2_Human4.42319797
4* SOX2_20726797_ChIP-Seq_SW620_Human3.22615856
5GATA4_25053715_ChIP-Seq_YYC3_Human3.20961504
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.20312871
7CDX2_19796622_ChIP-Seq_MESCs_Mouse3.01328278
8GATA6_25053715_ChIP-Seq_YYC3_Human2.98423303
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.87009258
10FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.65021757
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63563725
12* ESR1_20079471_ChIP-ChIP_T-47D_Human2.62219143
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.61809417
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.60379198
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.58191541
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.54626713
17ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.23595262
18ZNF263_19887448_ChIP-Seq_K562_Human2.20922134
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.17404223
20RUNX1_27514584_Chip-Seq_MCF-7_Human2.10450354
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.09579135
22ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.08441239
23FOXO3_23340844_ChIP-Seq_DLD1_Human2.06155990
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.99393960
25SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.98527734
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98078117
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92869250
28* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90966571
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85377656
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.83874400
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83498469
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81295786
33KLF5_25053715_ChIP-Seq_YYC3_Human1.78251432
34* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.74769725
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74664410
36* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.74333623
37GATA3_24758297_ChIP-Seq_MCF-7_Human1.69910261
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.69672835
39ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.66287938
40FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.59617717
41RACK7_27058665_Chip-Seq_MCF-7_Human1.59409743
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55128777
43* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54814453
44* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54814453
45CLOCK_20551151_ChIP-Seq_293T_Human1.51407340
46LXR_22292898_ChIP-Seq_THP-1_Human1.50985785
47FOXM1_26456572_ChIP-Seq_MCF-7_Human1.50334936
48AR_21909140_ChIP-Seq_LNCAP_Human1.49024485
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44282273
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44282273
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44282273
52AHR_22903824_ChIP-Seq_MCF-7_Human1.43958866
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38030768
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36384507
55* FOXA1_25552417_ChIP-Seq_VCAP_Human1.35108319
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34771049
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34678975
58TCF4_18268006_ChIP-ChIP_LS174T_Human1.33761297
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30098442
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29546687
61ATF3_27146783_Chip-Seq_COLON_Human1.25812699
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20990572
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17573189
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17413043
65* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15668210
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.12801052
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12546419
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11279249
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10838120
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10113638
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09413563
72CREB1_26743006_Chip-Seq_LNCaP_Human1.08735303
73ELF5_23300383_ChIP-Seq_T47D_Human1.08501540
74TP63_22573176_ChIP-Seq_HFKS_Human1.06915225
75BCAT_22108803_ChIP-Seq_LS180_Human1.04529376
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04350849
77P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04332056
78FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03730242
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03718897
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01518118
81ARNT_22903824_ChIP-Seq_MCF-7_Human0.98397447
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98281759
83RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97427749
84GATA2_19941826_ChIP-Seq_K562_Human0.97243233
85* CDX2_22108803_ChIP-Seq_LS180_Human0.96810199
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96713797
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96198615
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94622332
89SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94113018
90STAT1_20625510_ChIP-Seq_HELA_Human0.93600840
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.92722788
92CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91753525
93CHD1_26751641_Chip-Seq_LNCaP_Human0.91482574
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90330489
95VDR_22108803_ChIP-Seq_LS180_Human0.90181461
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89635493
97ERG_21242973_ChIP-ChIP_JURKAT_Human0.89402945
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88863990
99HNF4A_19822575_ChIP-Seq_HepG2_Human0.88859317
100IRF8_22096565_ChIP-ChIP_GC-B_Human0.88742858
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87888998
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87888998
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86439335
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86353766
105GATA2_21666600_ChIP-Seq_HMVEC_Human0.86313605
106SMC4_20622854_ChIP-Seq_HELA_Human0.84525924
107CJUN_26792858_Chip-Seq_BT549_Human0.84260142
108RXR_22108803_ChIP-Seq_LS180_Human0.84111009
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83636934
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83400563
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83298810
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82395682
113DROSHA_22980978_ChIP-Seq_HELA_Human0.81968874
114TBX20_22080862_ChIP-Seq_HEART_Mouse0.81827152
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.81827152
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81825283
117GATA1_19941826_ChIP-Seq_K562_Human0.81303195
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80976472
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80963896
120ELK3_25401928_ChIP-Seq_HUVEC_Human0.78974894
121* CEBPB_22108803_ChIP-Seq_LS180_Human0.78774736
122TP63_23658742_ChIP-Seq_EP156T_Human0.78521853
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77948288
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77046949
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75813331
126EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.75769475
127TP53_16413492_ChIP-PET_HCT116_Human0.75024280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.73851719
2MP0001873_stomach_inflammation4.78664618
3MP0008004_abnormal_stomach_pH4.51834892
4MP0004264_abnormal_extraembryonic_tissu4.29700040
5MP0003866_abnormal_defecation3.63459228
6MP0001666_abnormal_nutrient_absorption3.44366188
7MP0008875_abnormal_xenobiotic_pharmacok3.35165804
8MP0001663_abnormal_digestive_system3.20358272
9MP0001664_abnormal_digestion2.98697322
10MP0003300_gastrointestinal_ulcer2.89795572
11MP0005381_digestive/alimentary_phenotyp2.86371933
12MP0005083_abnormal_biliary_tract2.84838055
13MP0000462_abnormal_digestive_system2.78368060
14MP0005310_abnormal_salivary_gland2.76939719
15MP0000537_abnormal_urethra_morphology2.75768600
16* MP0010155_abnormal_intestine_physiology2.75097912
17MP0004043_abnormal_pH_regulation2.49151812
18MP0005360_urolithiasis2.29132095
19MP0003868_abnormal_feces_composition2.24985223
20* MP0000477_abnormal_intestine_morphology2.12153540
21MP0010352_gastrointestinal_tract_polyps2.11624609
22MP0005085_abnormal_gallbladder_physiolo2.11290645
23MP0002166_altered_tumor_susceptibility2.03322293
24MP0005365_abnormal_bile_salt1.97880559
25MP0000613_abnormal_salivary_gland1.92708796
26MP0002277_abnormal_respiratory_mucosa1.91069031
27MP0000470_abnormal_stomach_morphology1.90718588
28MP0006054_spinal_hemorrhage1.87815784
29MP0002139_abnormal_hepatobiliary_system1.77824918
30MP0005409_darkened_coat_color1.77047695
31MP0003878_abnormal_ear_physiology1.72381577
32MP0005377_hearing/vestibular/ear_phenot1.72381577
33* MP0000490_abnormal_crypts_of1.70573175
34MP0001765_abnormal_ion_homeostasis1.68688796
35MP0000566_synostosis1.67374087
36MP0010678_abnormal_skin_adnexa1.57315159
37MP0003705_abnormal_hypodermis_morpholog1.55752450
38MP0002006_tumorigenesis1.54097115
39MP0003806_abnormal_nucleotide_metabolis1.48555707
40MP0002132_abnormal_respiratory_system1.47906781
41MP0010386_abnormal_urinary_bladder1.46535110
42MP0005394_taste/olfaction_phenotype1.44251666
43MP0005499_abnormal_olfactory_system1.44251666
44MP0003252_abnormal_bile_duct1.43417843
45MP0009780_abnormal_chondrocyte_physiolo1.37985677
46MP0000678_abnormal_parathyroid_gland1.36839214
47MP0003938_abnormal_ear_development1.36527696
48MP0005636_abnormal_mineral_homeostasis1.33879524
49MP0000538_abnormal_urinary_bladder1.33660779
50MP0004858_abnormal_nervous_system1.33553077
51MP0000465_gastrointestinal_hemorrhage1.32781950
52MP0002009_preneoplasia1.32270000
53MP0004147_increased_porphyrin_level1.30918595
54MP0005166_decreased_susceptibility_to1.28071554
55MP0005647_abnormal_sex_gland1.27423962
56MP0002876_abnormal_thyroid_physiology1.23386836
57MP0003183_abnormal_peptide_metabolism1.23343858
58MP0002796_impaired_skin_barrier1.20405026
59MP0009643_abnormal_urine_homeostasis1.18282910
60MP0005165_increased_susceptibility_to1.17989766
61MP0000627_abnormal_mammary_gland1.16441838
62MP0002822_catalepsy1.12101153
63MP0001881_abnormal_mammary_gland1.11867085
64MP0000681_abnormal_thyroid_gland1.08978880
65MP0002896_abnormal_bone_mineralization1.08476632
66MP0002089_abnormal_postnatal_growth/wei1.06191590
67MP0008789_abnormal_olfactory_epithelium1.04835888
68MP0001849_ear_inflammation1.02789789
69MP0002098_abnormal_vibrissa_morphology1.00300367
70MP0001756_abnormal_urination1.00128644
71MP0000467_abnormal_esophagus_morphology0.99782267
72MP0009764_decreased_sensitivity_to0.99310687
73MP0010329_abnormal_lipoprotein_level0.98993229
74MP0000383_abnormal_hair_follicle0.95041798
75MP0009384_cardiac_valve_regurgitation0.93318900
76MP0005367_renal/urinary_system_phenotyp0.89477003
77MP0000516_abnormal_urinary_system0.89477003
78MP0002653_abnormal_ependyma_morphology0.89083070
79MP0000858_altered_metastatic_potential0.89008407
80MP0003453_abnormal_keratinocyte_physiol0.88676501
81MP0003315_abnormal_perineum_morphology0.84194672
82MP0003191_abnormal_cellular_cholesterol0.78889300
83MP0005058_abnormal_lysosome_morphology0.78276403
84MP0002136_abnormal_kidney_physiology0.77260081
85MP0001216_abnormal_epidermal_layer0.76614817
86MP0010030_abnormal_orbit_morphology0.76296867
87MP0005319_abnormal_enzyme/_coenzyme0.75441261
88MP0005666_abnormal_adipose_tissue0.75331412
89MP0003186_abnormal_redox_activity0.74355942
90MP0004019_abnormal_vitamin_homeostasis0.72404352
91MP0005187_abnormal_penis_morphology0.71947811
92MP0003075_altered_response_to0.71264433
93MP0009053_abnormal_anal_canal0.71208470
94MP0004947_skin_inflammation0.70053341
95MP0002060_abnormal_skin_morphology0.69400213
96MP0005164_abnormal_response_to0.69348225
97MP0003329_amyloid_beta_deposits0.69134101
98MP0009379_abnormal_foot_pigmentation0.69043447
99MP0003566_abnormal_cell_adhesion0.68883725
100MP0005332_abnormal_amino_acid0.68542156
101MP0003941_abnormal_skin_development0.67926521
102MP0004782_abnormal_surfactant_physiolog0.66043216
103MP0008872_abnormal_physiological_respon0.65930927
104MP0000762_abnormal_tongue_morphology0.64937948
105MP0003656_abnormal_erythrocyte_physiolo0.62982800
106MP0005167_abnormal_blood-brain_barrier0.62699902
107MP0005220_abnormal_exocrine_pancreas0.62589849
108MP0002909_abnormal_adrenal_gland0.62511133
109MP0003638_abnormal_response/metabolism_0.61589513
110MP0003283_abnormal_digestive_organ0.61354051
111MP0004484_altered_response_of0.60410316
112MP0005248_abnormal_Harderian_gland0.60065477
113MP0000609_abnormal_liver_physiology0.60001538
114MP0005501_abnormal_skin_physiology0.59806590
115MP0005408_hypopigmentation0.59405815
116MP0000377_abnormal_hair_follicle0.59357709
117MP0002118_abnormal_lipid_homeostasis0.58207385
118MP0003724_increased_susceptibility_to0.58142717
119MP0005451_abnormal_body_composition0.58121857
120MP0003119_abnormal_digestive_system0.57867880
121* MP0001845_abnormal_inflammatory_respons0.57462561
122MP0001346_abnormal_lacrimal_gland0.57374009
123MP0009840_abnormal_foam_cell0.57114926
124MP0009765_abnormal_xenobiotic_induced0.56745911
125MP0002254_reproductive_system_inflammat0.54421751
126MP0004185_abnormal_adipocyte_glucose0.54377768
127MP0005023_abnormal_wound_healing0.53349977
128MP0000427_abnormal_hair_cycle0.51342389

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.37268239
2Right ventricular cardiomyopathy (HP:0011663)7.30588424
3Abnormal respiratory motile cilium physiology (HP:0012261)6.19467853
4Abnormal respiratory motile cilium morphology (HP:0005938)6.16242037
5Abnormal respiratory epithelium morphology (HP:0012253)6.16242037
6Rhinitis (HP:0012384)6.03922603
7Chronic bronchitis (HP:0004469)5.95079988
8Absent/shortened dynein arms (HP:0200106)5.84006146
9Dynein arm defect of respiratory motile cilia (HP:0012255)5.84006146
10Abnormal ciliary motility (HP:0012262)5.82581872
11Ileus (HP:0002595)5.56060654
12Bronchiectasis (HP:0002110)4.81744267
13Nasal polyposis (HP:0100582)4.68395391
14Micronodular cirrhosis (HP:0001413)4.45531346
15Abdominal distention (HP:0003270)4.43124858
16Azoospermia (HP:0000027)4.33132601
17Abnormality of the nasal mucosa (HP:0000433)4.24033511
18Hyperactive renin-angiotensin system (HP:0000841)4.09926389
19Rectal prolapse (HP:0002035)4.04823361
20Short nail (HP:0001799)3.99746731
21Abnormal tarsal ossification (HP:0008369)3.77922819
22Abnormal foot bone ossification (HP:0010675)3.69505817
23Broad metatarsal (HP:0001783)3.64695608
24Malnutrition (HP:0004395)3.64152705
25Flat acetabular roof (HP:0003180)3.51281185
26Abnormality of cochlea (HP:0000375)3.46889780
27Abnormality of chloride homeostasis (HP:0011422)3.43448067
28Bronchitis (HP:0012387)3.42237990
29Palpitations (HP:0001962)3.39663266
30Conjugated hyperbilirubinemia (HP:0002908)3.36017771
31Woolly hair (HP:0002224)3.28538985
32Syncope (HP:0001279)3.24531256
33Biliary tract neoplasm (HP:0100574)3.13483747
34Abnormality of the 1st metacarpal (HP:0010009)3.13390676
35Abnormality of the 2nd finger (HP:0004100)3.08097208
36Abnormal biliary tract morphology (HP:0012440)3.05427130
37Pili torti (HP:0003777)3.02630451
38Renal salt wasting (HP:0000127)3.01573913
39Onycholysis (HP:0001806)2.99564297
40Vacuolated lymphocytes (HP:0001922)2.98927853
41Abnormal spermatogenesis (HP:0008669)2.98637543
42Infertility (HP:0000789)2.93101517
43Chronic diarrhea (HP:0002028)2.90809370
44Mildly elevated creatine phosphokinase (HP:0008180)2.89029875
45Facial shape deformation (HP:0011334)2.87854777
46Potter facies (HP:0002009)2.87854777
47Fat malabsorption (HP:0002630)2.82952765
48Villous atrophy (HP:0011473)2.81900215
49Abnormality of small intestinal villus morphology (HP:0011472)2.81900215
50Recurrent sinusitis (HP:0011108)2.78506582
51Chronic sinusitis (HP:0011109)2.75890979
52Hyperaldosteronism (HP:0000859)2.74991462
53Metabolic alkalosis (HP:0200114)2.74021589
54Symphalangism affecting the phalanges of the hand (HP:0009773)2.69861041
55Vertebral arch anomaly (HP:0008438)2.68654025
56Milia (HP:0001056)2.68606682
57Microretrognathia (HP:0000308)2.66888369
58Hyperkalemia (HP:0002153)2.64680501
59Tubulointerstitial nephritis (HP:0001970)2.61698124
60Recurrent otitis media (HP:0000403)2.60590251
61Hypotension (HP:0002615)2.58299999
62Short 1st metacarpal (HP:0010034)2.56341999
63Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.56341999
64Hypoplasia of the uterus (HP:0000013)2.55680112
65Aortic aneurysm (HP:0004942)2.53439622
66Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51172309
67Short hallux (HP:0010109)2.50955294
68Congenital sensorineural hearing impairment (HP:0008527)2.49121725
69Ventricular fibrillation (HP:0001663)2.48690903
70Exocrine pancreatic insufficiency (HP:0001738)2.46641048
71Hyponatremia (HP:0002902)2.46319082
72Abnormality of the gastric mucosa (HP:0004295)2.45224879
73Progressive sensorineural hearing impairment (HP:0000408)2.44528732
74Abnormality of the proximal phalanges of the hand (HP:0009834)2.44355686
75Curly hair (HP:0002212)2.43931726
76Abnormality of the middle phalanges of the toes (HP:0010183)2.43666430
77Gastrointestinal dysmotility (HP:0002579)2.43594360
78Esophageal varix (HP:0002040)2.42266897
79Gout (HP:0001997)2.41313036
80Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.40025973
81Beaking of vertebral bodies (HP:0004568)2.38967373
82Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.38691994
83Bundle branch block (HP:0011710)2.37452508
84Atrophic scars (HP:0001075)2.33892207
85Abnormality of proline metabolism (HP:0010907)2.33862051
86Hydroxyprolinuria (HP:0003080)2.33862051
87Vascular calcification (HP:0004934)2.30850872
88Alkalosis (HP:0001948)2.29841349
89Hemorrhage of the eye (HP:0011885)2.29523688
90Dehydration (HP:0001944)2.27803324
91Pustule (HP:0200039)2.27380356
92Abnormality of carpal bone ossification (HP:0006257)2.26482265
93Hyperglycinuria (HP:0003108)2.26231102
94Aplasia/Hypoplasia of the hallux (HP:0008362)2.25312687
95Goiter (HP:0000853)2.24689941
96Intrahepatic cholestasis (HP:0001406)2.24567372
97Widely patent fontanelles and sutures (HP:0004492)2.23965283
98Chronic otitis media (HP:0000389)2.23756783
99Cone-rod dystrophy (HP:0000548)2.23018257
100Abnormality of the vitamin B12 metabolism (HP:0004341)2.22859681
101Ureteral stenosis (HP:0000071)2.21283274
102Abnormality of the lumbar spine (HP:0100712)2.20546977
103Progressive hearing impairment (HP:0001730)2.19701794
104Reduced antithrombin III activity (HP:0001976)2.16325721
105Morphological abnormality of the inner ear (HP:0011390)2.12694604
106Abnormality of renin-angiotensin system (HP:0000847)2.11922305
107Fragile nails (HP:0001808)2.11198359
108Neoplasm of the small intestine (HP:0100833)2.10419035
109Spinal cord compression (HP:0002176)2.10384380
110Long toe (HP:0010511)2.10164558
111Thoracic kyphosis (HP:0002942)2.09783802
112Hyperparathyroidism (HP:0000843)2.09652621
113Hyperphosphatemia (HP:0002905)2.09209277
114Hypoalbuminemia (HP:0003073)2.08538720
115Abnormal albumin level (HP:0012116)2.08538720
116Abnormal hair laboratory examination (HP:0003328)2.07185567
117Neoplasm of the rectum (HP:0100743)2.07156255
118Male infertility (HP:0003251)2.06206399
119Plantar hyperkeratosis (HP:0007556)2.05926423
120Systemic lupus erythematosus (HP:0002725)2.05056617
121Ureteral obstruction (HP:0006000)2.03487047
122Abnormality of vitamin B metabolism (HP:0004340)2.02476677
123Cardiovascular calcification (HP:0011915)2.01598508
124Ventricular tachycardia (HP:0004756)2.00992072
125Abnormal hand bone ossification (HP:0010660)1.99711934
126Ventricular arrhythmia (HP:0004308)1.96671339
127Glomerulosclerosis (HP:0000096)1.96384671
128Short phalanx of the thumb (HP:0009660)1.96218105
129Flattened epiphyses (HP:0003071)1.95558366
130Abnormality of vitamin metabolism (HP:0100508)1.94481637
131Cupped ribs (HP:0000887)1.93183890
132Abnormality of the distal phalanges of the toes (HP:0010182)1.91893886
133Proximal tubulopathy (HP:0000114)1.91330703
134Hyperammonemia (HP:0001987)1.91148105
135Congenital, generalized hypertrichosis (HP:0004540)1.90965739
136Decreased circulating renin level (HP:0003351)1.90902574
137Mucopolysacchariduria (HP:0008155)1.90469324
138Urinary glycosaminoglycan excretion (HP:0003541)1.90469324
139Myopathic facies (HP:0002058)1.90447597
140Abnormality of monocarboxylic acid metabolism (HP:0010996)1.89273519
141Atelectasis (HP:0100750)1.89261226
142Abnormal cartilage morphology (HP:0002763)1.87000034
143Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86112048
144Thin bony cortex (HP:0002753)1.85674598
145Amyloidosis (HP:0011034)1.85433088
146Prolonged QT interval (HP:0001657)1.85384627
147Steatorrhea (HP:0002570)1.84755382
148Abnormality of sodium homeostasis (HP:0010931)1.84529115
149Abnormality of the distal phalanx of the thumb (HP:0009617)1.83398619
150Aortic dissection (HP:0002647)1.82657574
151Abnormal ossification of hand bones (HP:0005921)1.81305419
152Hyperuricemia (HP:0002149)1.79465010
153Increased purine levels (HP:0004368)1.79465010
154Severe short stature (HP:0003510)1.78499343
155Growth hormone excess (HP:0000845)1.75080125
156Distal upper limb amyotrophy (HP:0007149)1.73006053
157Upper limb amyotrophy (HP:0009129)1.73006053
158Abnormality of the thoracic spine (HP:0100711)1.71240359
159Abnormality of permanent molar morphology (HP:0011071)1.70632173
160Abnormality of the dental root (HP:0006486)1.70632173
161Taurodontia (HP:0000679)1.70632173
162Glomerulonephritis (HP:0000099)1.70598788
163Ankle clonus (HP:0011448)1.70568364
164Recurrent bronchitis (HP:0002837)1.68409116
165Abnormal glucose tolerance (HP:0001952)1.65166184
166Redundant skin (HP:0001582)1.64853045
167Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.64140558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.45399771
2MST45.70737767
3LMTK24.27954190
4MST1R3.80138775
5AKT32.87039753
6MAP2K22.75361417
7MAPK152.73621810
8NME12.69975623
9ERN12.64218787
10MAP3K22.57589478
11MYLK2.46609104
12PIK3CA2.43979090
13LATS12.35215163
14TESK12.33157466
15RPS6KB22.24040670
16PBK2.13246594
17NUAK12.10374288
18TAOK31.99326769
19PTK61.88424748
20ACVR1B1.87555886
21EEF2K1.84662090
22PRKG21.81147523
23ERBB41.75753754
24EPHA21.66000437
25FER1.47866360
26STK391.44555671
27MAP2K11.41135449
28RIPK11.40525124
29MET1.39762618
30SMG11.39373127
31FGFR41.31758198
32ZAP701.21312545
33MAPKAPK31.17895809
34EPHB21.14254896
35PRKCI1.09689945
36BCKDK1.07711822
37EPHA31.07623298
38STK101.06961258
39LRRK21.03487237
40KSR20.99641038
41TAOK10.99044980
42MAP3K30.98803657
43MAP3K70.96672654
44LIMK10.94184456
45TRIB30.90058535
46SCYL20.88441696
47CAMK2D0.87134473
48DMPK0.86104742
49PDK20.80836552
50PIK3CG0.78246221
51PTK20.75996952
52NEK60.71909134
53NME20.68619309
54CDC42BPA0.68186474
55IRAK30.67513064
56BMPR20.67168305
57ERBB20.66955545
58MAP2K60.66197053
59TTN0.65546550
60PAK30.65311605
61TBK10.63369499
62CAMK2B0.62408759
63PAK40.62374519
64FGFR30.61877831
65TRPM70.59086971
66CAMK2G0.57848980
67MAP3K80.57677332
68RIPK40.57521323
69PKN20.55551202
70GRK60.54382532
71OXSR10.54250397
72STK30.52235954
73PDK30.50796841
74PDK40.50796841
75PRPF4B0.49504108
76MAP3K100.49470245
77ROCK10.48825122
78MAP3K110.48408250
79DDR20.47380723
80SIK10.46889564
81MAP3K10.45193783
82IRAK10.43226875
83EIF2AK10.41773907
84MATK0.41126454
85TYK20.41064684
86EPHB10.39413405
87RET0.39126156
88STK38L0.38461058
89ICK0.38387169
90GRK10.36347665
91MAP3K120.35289054
92STK240.35202864
93ROCK20.34766598
94PDPK10.34735157
95PRKAA20.34692735
96TTK0.34657108
97WNK40.34513108
98MUSK0.33594617
99PAK20.33052850
100YES10.32185825
101ABL20.31525909
102NEK10.31396824
103PDGFRA0.31333241
104ERBB30.30967309
105PAK10.30341367
106PRKCD0.29883017
107PIM20.28335467
108MAPKAPK20.27157153
109RPS6KA20.26385057
110BMX0.26338518
111TEC0.26159619
112AURKB0.25100034
113FYN0.24676914
114SRC0.23299993
115PRKAA10.22436638
116HIPK20.22301838
117CAMKK10.22274607
118PRKCA0.20545459
119CSNK1A10.20510077
120MARK20.20102267
121CDK60.19349297
122DYRK1B0.19202726
123BCR0.19127547
124PRKCQ0.19066975
125PDGFRB0.18761311
126CHUK0.18522582
127ILK0.18264162
128JAK20.17841555
129PDK10.17807618
130INSRR0.17185547
131MAP2K30.17033576
132TESK20.16715445
133CSK0.16440360
134JAK10.16336426
135CDK80.15981306
136MELK0.14640764
137EIF2AK30.14427125
138PRKCE0.13208318
139MAPK110.13098888

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.89276166
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.61957580
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.58301667
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.26795525
5Pentose and glucuronate interconversions_Homo sapiens_hsa000403.14486871
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.89471572
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.82444395
8Mineral absorption_Homo sapiens_hsa049782.79209936
9Fat digestion and absorption_Homo sapiens_hsa049752.67695468
10Phenylalanine metabolism_Homo sapiens_hsa003602.44380726
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.21906037
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.13139519
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.12416339
14Tyrosine metabolism_Homo sapiens_hsa003501.85083970
15Renin-angiotensin system_Homo sapiens_hsa046141.75569476
16Fructose and mannose metabolism_Homo sapiens_hsa000511.71486780
17Chemical carcinogenesis_Homo sapiens_hsa052041.71226928
18Glutathione metabolism_Homo sapiens_hsa004801.69753239
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.61300371
20Starch and sucrose metabolism_Homo sapiens_hsa005001.59713637
21Vibrio cholerae infection_Homo sapiens_hsa051101.52386679
22Bile secretion_Homo sapiens_hsa049761.52370835
23Linoleic acid metabolism_Homo sapiens_hsa005911.42353832
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41837078
25Galactose metabolism_Homo sapiens_hsa000521.41658209
26Tight junction_Homo sapiens_hsa045301.41325183
27Pancreatic secretion_Homo sapiens_hsa049721.38225272
28Histidine metabolism_Homo sapiens_hsa003401.36941157
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31608575
30N-Glycan biosynthesis_Homo sapiens_hsa005101.26944994
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.23716184
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12972367
33Gastric acid secretion_Homo sapiens_hsa049711.10332961
34Thyroid hormone synthesis_Homo sapiens_hsa049181.09000652
35Fatty acid degradation_Homo sapiens_hsa000711.04097120
36Protein digestion and absorption_Homo sapiens_hsa049741.01018810
37Nitrogen metabolism_Homo sapiens_hsa009100.99053765
38Arachidonic acid metabolism_Homo sapiens_hsa005900.98823632
39Leukocyte transendothelial migration_Homo sapiens_hsa046700.98306156
40Sulfur relay system_Homo sapiens_hsa041220.86906442
41Hepatitis C_Homo sapiens_hsa051600.86887707
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85652112
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85511601
44Retinol metabolism_Homo sapiens_hsa008300.85244993
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84135402
46Glycerolipid metabolism_Homo sapiens_hsa005610.80802343
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.80274527
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79525401
49Tryptophan metabolism_Homo sapiens_hsa003800.77840547
50Protein export_Homo sapiens_hsa030600.76474774
51Butanoate metabolism_Homo sapiens_hsa006500.74934225
52Caffeine metabolism_Homo sapiens_hsa002320.73354595
53Adherens junction_Homo sapiens_hsa045200.72073088
54PPAR signaling pathway_Homo sapiens_hsa033200.71571742
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71215340
56Other glycan degradation_Homo sapiens_hsa005110.70710685
57ABC transporters_Homo sapiens_hsa020100.70217211
58Propanoate metabolism_Homo sapiens_hsa006400.67725638
59Fatty acid biosynthesis_Homo sapiens_hsa000610.67303690
60Pyruvate metabolism_Homo sapiens_hsa006200.65171529
61Vitamin digestion and absorption_Homo sapiens_hsa049770.63768161
62Peroxisome_Homo sapiens_hsa041460.62624728
63Arginine and proline metabolism_Homo sapiens_hsa003300.62440454
64beta-Alanine metabolism_Homo sapiens_hsa004100.61124502
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61005034
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59628106
67Thyroid cancer_Homo sapiens_hsa052160.58073784
68Lysosome_Homo sapiens_hsa041420.56576691
69Bladder cancer_Homo sapiens_hsa052190.55599727
70Ether lipid metabolism_Homo sapiens_hsa005650.55356031
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.54372137
72Fatty acid metabolism_Homo sapiens_hsa012120.54323818
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.54129349
74Salivary secretion_Homo sapiens_hsa049700.52694959
75Asthma_Homo sapiens_hsa053100.52173761
76Amoebiasis_Homo sapiens_hsa051460.50506348
77Collecting duct acid secretion_Homo sapiens_hsa049660.48196431
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45783185
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44670469
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43571629
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.43073999
82Endometrial cancer_Homo sapiens_hsa052130.42752073
83Pentose phosphate pathway_Homo sapiens_hsa000300.41157031
84Carbon metabolism_Homo sapiens_hsa012000.39390932
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.38771838
86Folate biosynthesis_Homo sapiens_hsa007900.36662211
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36054960
88Salmonella infection_Homo sapiens_hsa051320.34503087
89Renin secretion_Homo sapiens_hsa049240.34413068
90Oxidative phosphorylation_Homo sapiens_hsa001900.33932797
91Arginine biosynthesis_Homo sapiens_hsa002200.32771627
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.32021676
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31828472
94Metabolic pathways_Homo sapiens_hsa011000.28290209
95Sphingolipid metabolism_Homo sapiens_hsa006000.27881430
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26921441
97Prostate cancer_Homo sapiens_hsa052150.26873904
98Influenza A_Homo sapiens_hsa051640.25963455
99Staphylococcus aureus infection_Homo sapiens_hsa051500.25058226
100Selenocompound metabolism_Homo sapiens_hsa004500.24910655
101Choline metabolism in cancer_Homo sapiens_hsa052310.24632245
102Antigen processing and presentation_Homo sapiens_hsa046120.23516885
103Allograft rejection_Homo sapiens_hsa053300.22859162
104Endocytosis_Homo sapiens_hsa041440.22850056
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22646255
106African trypanosomiasis_Homo sapiens_hsa051430.21344558
107Autoimmune thyroid disease_Homo sapiens_hsa053200.20997375
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.20377872
109Alzheimers disease_Homo sapiens_hsa050100.20103707
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.19423846
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18864616
112Small cell lung cancer_Homo sapiens_hsa052220.17842018
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17320230
114Inositol phosphate metabolism_Homo sapiens_hsa005620.16831487
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16550670
116Insulin resistance_Homo sapiens_hsa049310.16306232
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15426468
118Focal adhesion_Homo sapiens_hsa045100.14666286
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14209080
120Graft-versus-host disease_Homo sapiens_hsa053320.14132228
121ECM-receptor interaction_Homo sapiens_hsa045120.12723138
122Toxoplasmosis_Homo sapiens_hsa051450.12223118
123Viral myocarditis_Homo sapiens_hsa054160.11511790
124Pertussis_Homo sapiens_hsa051330.10795037
125Ovarian steroidogenesis_Homo sapiens_hsa049130.07970599

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