AGR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.79767189
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.63529276
3response to nitrosative stress (GO:0051409)9.41633714
4auditory receptor cell differentiation (GO:0042491)8.95264742
5epithelial cilium movement (GO:0003351)8.76152834
6xenobiotic catabolic process (GO:0042178)7.94184227
7primary alcohol catabolic process (GO:0034310)7.28806841
8vitamin transmembrane transport (GO:0035461)6.86114432
9pentose metabolic process (GO:0019321)6.80844327
10axoneme assembly (GO:0035082)6.68152426
11ethanol metabolic process (GO:0006067)6.41002192
12inner ear receptor cell differentiation (GO:0060113)6.18836880
13left/right pattern formation (GO:0060972)5.68348963
14myoblast migration (GO:0051451)5.47792484
15ethanol oxidation (GO:0006069)5.26215781
16negative regulation of keratinocyte proliferation (GO:0010839)5.24411920
17hair cell differentiation (GO:0035315)5.23343898
18pyrimidine-containing compound transmembrane transport (GO:0072531)5.22291636
19diterpenoid biosynthetic process (GO:0016102)5.00310466
20regulation of cilium movement (GO:0003352)4.94873148
21regulation of female gonad development (GO:2000194)4.94706609
22uronic acid metabolic process (GO:0006063)4.88435884
23glucuronate metabolic process (GO:0019585)4.88435884
24cellular glucuronidation (GO:0052695)4.82950040
25Notch signaling involved in heart development (GO:0061314)4.72294001
26mechanoreceptor differentiation (GO:0042490)4.69996947
27regulation of somitogenesis (GO:0014807)4.69012599
28left/right axis specification (GO:0070986)4.62964455
29regulation of secondary heart field cardioblast proliferation (GO:0003266)4.56534428
30regulation of cardioblast proliferation (GO:0003264)4.56534428
31exogenous drug catabolic process (GO:0042738)4.48336506
32negative regulation of JUN kinase activity (GO:0043508)4.47521509
33calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.43522840
34aorta morphogenesis (GO:0035909)4.42903103
35regulation of keratinocyte proliferation (GO:0010837)4.36139319
36O-glycan processing (GO:0016266)4.35741385
37angiotensin maturation (GO:0002003)4.33197555
38negative regulation of humoral immune response (GO:0002921)4.30665912
39generation of neurons (GO:0048699)4.28379415
40endocardial cushion morphogenesis (GO:0003203)4.28350104
41glutathione derivative metabolic process (GO:1901685)4.21699980
42glutathione derivative biosynthetic process (GO:1901687)4.21699980
43epoxygenase P450 pathway (GO:0019373)4.17811746
44regulation of skeletal muscle contraction (GO:0014819)4.11636201
45sperm capacitation (GO:0048240)4.05780609
46positive regulation of neurological system process (GO:0031646)4.04365263
47microtubule bundle formation (GO:0001578)4.03861344
48ventricular system development (GO:0021591)3.99115427
49tight junction assembly (GO:0070830)3.97465143
50intestinal epithelial cell development (GO:0060576)3.96461196
51DNA damage induced protein phosphorylation (GO:0006975)3.94291688
52drug catabolic process (GO:0042737)3.91725047
53interleukin-6-mediated signaling pathway (GO:0070102)3.87905635
54positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.87389228
55phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.82985917
56primary alcohol metabolic process (GO:0034308)3.75796834
57notochord development (GO:0030903)3.73070726
58regulation of keratinocyte differentiation (GO:0045616)3.71227733
59oligosaccharide biosynthetic process (GO:0009312)3.71089421
60response to xenobiotic stimulus (GO:0009410)3.70090351
61regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.68793572
62response to caffeine (GO:0031000)3.65098034
63energy homeostasis (GO:0097009)3.63395461
64sulfate transmembrane transport (GO:1902358)3.60739570
65female gonad development (GO:0008585)3.60425197
66one-carbon compound transport (GO:0019755)3.56856780
67artery smooth muscle contraction (GO:0014824)3.54969658
68multicellular organismal water homeostasis (GO:0050891)3.54008377
69intraciliary transport (GO:0042073)3.53750514
70regulation of chemokine secretion (GO:0090196)3.52751696
71negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.52714396
72regulation of RIG-I signaling pathway (GO:0039535)3.51697544
73regulation of interleukin-5 production (GO:0032674)3.49722183
74piRNA metabolic process (GO:0034587)3.43212549
75negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.42614024
76sphingomyelin metabolic process (GO:0006684)3.41854469
77positive regulation of Notch signaling pathway (GO:0045747)3.38986163
78cilium organization (GO:0044782)3.38916561
79lung epithelium development (GO:0060428)3.38160288
80positive regulation of Cdc42 GTPase activity (GO:0043089)3.37719186
81mesenchyme morphogenesis (GO:0072132)3.36009612
82negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.34393364
83regulation of guanylate cyclase activity (GO:0031282)3.34008094
84establishment of apical/basal cell polarity (GO:0035089)3.32006653
85sodium ion homeostasis (GO:0055078)3.30524061
86retinol metabolic process (GO:0042572)3.29995072
87muscle cell migration (GO:0014812)3.29499653
88excretion (GO:0007588)3.29490307
89regulation of interleukin-13 production (GO:0032656)3.28959499
90regulation of transforming growth factor beta2 production (GO:0032909)3.28657037
91drug metabolic process (GO:0017144)3.28301357
92regulation of sister chromatid cohesion (GO:0007063)3.28028191
93cilium assembly (GO:0042384)3.26817968
94intestinal absorption (GO:0050892)3.26689627
95lipoprotein transport (GO:0042953)3.25016612
96retinoic acid metabolic process (GO:0042573)3.23119994
97positive regulation of epidermal cell differentiation (GO:0045606)3.22751448
98terpenoid biosynthetic process (GO:0016114)3.22536296
99glomerular epithelial cell development (GO:0072310)3.20956376
100sulfate transport (GO:0008272)3.19537852
101tolerance induction (GO:0002507)3.19450274
102regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.19427355
103surfactant homeostasis (GO:0043129)3.19350854
104maintenance of gastrointestinal epithelium (GO:0030277)3.18645669
105negative regulation of T cell differentiation in thymus (GO:0033085)3.17680215
106pharyngeal system development (GO:0060037)3.17665268
107protein-chromophore linkage (GO:0018298)3.17344860
108regulation of epidermal cell differentiation (GO:0045604)3.16891775
109branching involved in salivary gland morphogenesis (GO:0060445)3.16399152
110negative regulation of immunoglobulin mediated immune response (GO:0002890)3.15551860
111negative regulation of B cell mediated immunity (GO:0002713)3.15551860
112neuronal stem cell maintenance (GO:0097150)3.14396128
113regulation of water loss via skin (GO:0033561)3.14020349
114L-ascorbic acid metabolic process (GO:0019852)3.12673466
115sensory perception of sound (GO:0007605)3.12151236
116transcytosis (GO:0045056)3.09549468
117positive regulation of megakaryocyte differentiation (GO:0045654)3.09507130
118bone remodeling (GO:0046849)3.09453513
119male meiosis (GO:0007140)3.09433142
120regulation of germinal center formation (GO:0002634)3.09107307
121citrulline biosynthetic process (GO:0019240)3.08827356
122digestion (GO:0007586)3.08158691
123regulation of transmission of nerve impulse (GO:0051969)3.07493717
124negative regulation of glial cell proliferation (GO:0060253)3.07395187
125protein polyglutamylation (GO:0018095)3.04013901
126sensory perception of mechanical stimulus (GO:0050954)3.04005234
127tonic smooth muscle contraction (GO:0014820)3.03825198
128cardiac right ventricle morphogenesis (GO:0003215)3.02781151
129DNA damage response, detection of DNA damage (GO:0042769)3.01913823
130epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.01537960
131negative regulation of smooth muscle cell differentiation (GO:0051151)3.01423107
132renal absorption (GO:0070293)2.98808126
133CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.98150607
134negative regulation of epidermal cell differentiation (GO:0045605)2.96834906
135negative regulation of transcription regulatory region DNA binding (GO:2000678)2.95846023
136regulation of steroid hormone biosynthetic process (GO:0090030)2.95515756
137water homeostasis (GO:0030104)2.93914130
138mitotic metaphase plate congression (GO:0007080)2.93468491
139glutathione biosynthetic process (GO:0006750)2.93434230
140positive regulation of chemokine secretion (GO:0090197)2.91718078
141centriole assembly (GO:0098534)2.91703390
142NADH metabolic process (GO:0006734)2.91585875
143cilium movement (GO:0003341)2.89463109
144relaxation of cardiac muscle (GO:0055119)2.88583812
145positive regulation of tolerance induction (GO:0002645)2.87740074
146glutathione metabolic process (GO:0006749)2.87334109
147heart valve formation (GO:0003188)2.85401882
148columnar/cuboidal epithelial cell development (GO:0002066)2.84651083
149regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.84554847
150protein O-linked glycosylation (GO:0006493)2.84320464
151nonribosomal peptide biosynthetic process (GO:0019184)2.84163319
152bundle of His cell to Purkinje myocyte communication (GO:0086069)2.84119471
153establishment of skin barrier (GO:0061436)2.83477320
154inner ear morphogenesis (GO:0042472)2.82159160
155progesterone metabolic process (GO:0042448)2.82010670
156male genitalia development (GO:0030539)2.81563155
157parturition (GO:0007567)2.80703648
158vitamin transport (GO:0051180)2.79312127
159cell projection assembly (GO:0030031)2.78955593
160heart valve morphogenesis (GO:0003179)2.78910124
161hydrogen peroxide biosynthetic process (GO:0050665)2.77838135
162thyroid hormone metabolic process (GO:0042403)2.76790945
163regulation of microtubule-based movement (GO:0060632)2.74360935
164benzene-containing compound metabolic process (GO:0042537)2.73819716
165amino-acid betaine transport (GO:0015838)2.73168963
166carnitine transport (GO:0015879)2.73168963
167iron ion import (GO:0097286)2.72122037
168microtubule-based movement (GO:0007018)2.70153703
169regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.69676904
170female gamete generation (GO:0007292)2.69003266
171establishment or maintenance of monopolar cell polarity (GO:0061339)2.67821406
172establishment of monopolar cell polarity (GO:0061162)2.67821406
173desmosome organization (GO:0002934)2.67415065
174cellular response to gamma radiation (GO:0071480)2.66780696
175carnitine metabolic process (GO:0009437)2.66264809
176T cell lineage commitment (GO:0002360)2.66140198
177sequestering of actin monomers (GO:0042989)2.64851548
178peptide catabolic process (GO:0043171)2.64112408
179positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.63693324
180regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.63182729
181endocrine process (GO:0050886)2.63182729
182regulation of systemic arterial blood pressure by hormone (GO:0001990)2.63182729
183sulfur compound transport (GO:0072348)2.62637976
184carnitine transmembrane transport (GO:1902603)2.61704803
185phenol-containing compound catabolic process (GO:0019336)2.61307552
186flavonoid metabolic process (GO:0009812)2.59696949
187antibacterial humoral response (GO:0019731)2.59465149
188axonemal dynein complex assembly (GO:0070286)14.8822098
189cilium or flagellum-dependent cell motility (GO:0001539)12.1673337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.58133097
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.82984696
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.66720048
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.37425724
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.70258680
6* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.58059669
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55932929
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22304476
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.12034215
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.11733306
11TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.09633731
12DROSHA_22980978_ChIP-Seq_HELA_Human2.09167381
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00807261
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97032963
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.95695160
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95041811
17RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90265553
18AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.86393505
19AR_21909140_ChIP-Seq_LNCAP_Human1.81965527
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.80686313
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72129148
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71496777
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70343377
24* AHR_22903824_ChIP-Seq_MCF-7_Human1.69772626
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.68354363
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.68064132
27* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.67966865
28KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.64497520
29GATA1_26923725_Chip-Seq_HPCs_Mouse1.64049953
30FOXA1_25552417_ChIP-Seq_VCAP_Human1.61988773
31ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.61697928
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.61219540
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.57525190
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55931709
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55931709
36RACK7_27058665_Chip-Seq_MCF-7_Human1.55729492
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.53778618
38P63_26484246_Chip-Seq_KERATINOCYTES_Human1.51993619
39TP53_18474530_ChIP-ChIP_U2OS_Human1.51712536
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.51422858
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48909535
42* KLF5_25053715_ChIP-Seq_YYC3_Human1.46385894
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43374668
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42133078
45CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41731931
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.41292434
47STAT1_20625510_ChIP-Seq_HELA_Human1.39693844
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39521580
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.38859185
50* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37617866
51* RUNX1_27514584_Chip-Seq_MCF-7_Human1.37551687
52* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35643144
53CLOCK_20551151_ChIP-Seq_293T_Human1.35446420
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35397935
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34327733
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33362062
57CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.32928037
58RNF2_27304074_Chip-Seq_NSC_Mouse1.32430423
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31487149
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30611548
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.30466464
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.30385936
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30244878
64SOX2_20726797_ChIP-Seq_SW620_Human1.28049973
65LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28041498
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27856238
67KAP1_22055183_ChIP-Seq_ESCs_Mouse1.26884521
68* ARNT_22903824_ChIP-Seq_MCF-7_Human1.26371522
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.24181821
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20727706
71GATA4_25053715_ChIP-Seq_YYC3_Human1.20227817
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19883726
73* GATA3_24758297_ChIP-Seq_MCF-7_Human1.19214615
74EZH2_22144423_ChIP-Seq_EOC_Human1.19211330
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18370246
76GATA1_19941826_ChIP-Seq_K562_Human1.17647850
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.15469535
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.14941396
79RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14799830
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.13028418
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12778509
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12258292
83TP63_22573176_ChIP-Seq_HFKS_Human1.10202905
84SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09485014
85* CJUN_26792858_Chip-Seq_BT549_Human1.09417024
86GATA2_19941826_ChIP-Seq_K562_Human1.09061519
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08801887
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08365301
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.07352373
90SMC4_20622854_ChIP-Seq_HELA_Human1.07030982
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06900154
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06900154
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05354074
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.05100738
95GATA6_25053715_ChIP-Seq_YYC3_Human1.04835827
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03737862
97RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03459288
98EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03459288
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02813012
100PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02523661
101SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01984727
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01490596
103PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00482738
104ISL1_27105846_Chip-Seq_CPCs_Mouse0.98788764
105* TAL1_26923725_Chip-Seq_HPCs_Mouse0.98740232
106HNFA_21074721_ChIP-Seq_CACO-2_Human0.98390938
107CREB1_26743006_Chip-Seq_LNCaP_Human0.98052572
108RXR_22108803_ChIP-Seq_LS180_Human0.96709987
109RING1B_27294783_Chip-Seq_ESCs_Mouse0.96351860
110TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96306424
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96142911
112BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94765862
113* STAT1_17558387_ChIP-Seq_HELA_Human0.93987715
114TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93913715
115CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93308148
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92836828
117FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92760406
118AR_21572438_ChIP-Seq_LNCaP_Human0.92650865
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92386289
120* CEBPB_22108803_ChIP-Seq_LS180_Human0.91554259
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91140833
122CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90951924
123EZH2_27294783_Chip-Seq_ESCs_Mouse0.90575065
124ZNF263_19887448_ChIP-Seq_K562_Human0.90025056
125CTCF_27219007_Chip-Seq_Bcells_Human0.89901602
126CDX2_22108803_ChIP-Seq_LS180_Human0.89460218
127ZFX_18555785_Chip-Seq_ESCs_Mouse0.89322662
128KLF4_18555785_Chip-Seq_ESCs_Mouse0.89318172
129FLI1_27457419_Chip-Seq_LIVER_Mouse0.88557025
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.88070160
131LXR_22292898_ChIP-Seq_THP-1_Human0.87513589
132SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87131891
133ETV1_20927104_ChIP-Seq_GIST48_Human0.87085257
134EWS_26573619_Chip-Seq_HEK293_Human0.87056198
135TP63_23658742_ChIP-Seq_EP156T_Human0.86703406
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86697386
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86638482
138PHF8_20622853_ChIP-Seq_HELA_Human0.86380490
139PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.86296551
140CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86188075
141STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85391214
142GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85292012
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84434751
144KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83162198
145KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83162198
146KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83162198
147SOX2_18555785_Chip-Seq_ESCs_Mouse0.83007227
148IGF1R_20145208_ChIP-Seq_DFB_Human0.82999798
149TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82359328
150OCT4_18555785_Chip-Seq_ESCs_Mouse0.82246430
151VDR_22108803_ChIP-Seq_LS180_Human0.82182687
152HNF4A_19822575_ChIP-Seq_HepG2_Human0.78860745
153RBPJ_21746931_ChIP-Seq_IB4_Human0.77683962
154P300_27268052_Chip-Seq_Bcells_Human0.77127756
155ELF5_23300383_ChIP-Seq_T47D_Human0.76995542
156GATA2_21666600_ChIP-Seq_HMVEC_Human0.76760195
157SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76380910
158SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76380910
159GATA6_21074721_ChIP-Seq_CACO-2_Human0.76138112
160MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.74777772
161NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73989861
162ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.73724205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot6.87510562
2MP0003878_abnormal_ear_physiology6.87510562
3MP0001485_abnormal_pinna_reflex4.97950832
4MP0003879_abnormal_hair_cell4.31314428
5MP0005360_urolithiasis3.68138435
6MP0008789_abnormal_olfactory_epithelium3.58541049
7MP0009780_abnormal_chondrocyte_physiolo3.32283511
8MP0001666_abnormal_nutrient_absorption3.23549911
9MP0004019_abnormal_vitamin_homeostasis3.19047504
10MP0010030_abnormal_orbit_morphology3.05350106
11MP0002653_abnormal_ependyma_morphology3.03656897
12MP0002139_abnormal_hepatobiliary_system3.02667773
13MP0005365_abnormal_bile_salt3.01620116
14MP0000026_abnormal_inner_ear2.79431971
15MP0010155_abnormal_intestine_physiology2.74248459
16MP0005499_abnormal_olfactory_system2.63230771
17MP0005394_taste/olfaction_phenotype2.63230771
18MP0000566_synostosis2.54711923
19MP0003183_abnormal_peptide_metabolism2.46372427
20MP0001963_abnormal_hearing_physiology2.41617155
21MP0008875_abnormal_xenobiotic_pharmacok2.35218396
22MP0001765_abnormal_ion_homeostasis2.26350489
23MP0005187_abnormal_penis_morphology2.09058223
24MP0002249_abnormal_larynx_morphology2.08051815
25MP0001346_abnormal_lacrimal_gland2.05218011
26MP0003866_abnormal_defecation2.02248718
27MP0010234_abnormal_vibrissa_follicle2.00729586
28MP0001664_abnormal_digestion1.96257532
29MP0002102_abnormal_ear_morphology1.91040299
30MP0000678_abnormal_parathyroid_gland1.88872839
31MP0002132_abnormal_respiratory_system1.87448533
32MP0000613_abnormal_salivary_gland1.87394914
33MP0005408_hypopigmentation1.86768130
34MP0000762_abnormal_tongue_morphology1.77991336
35MP0010352_gastrointestinal_tract_polyps1.77094950
36MP0003787_abnormal_imprinting1.74664086
37MP0003941_abnormal_skin_development1.72979106
38MP0009643_abnormal_urine_homeostasis1.72908029
39MP0005636_abnormal_mineral_homeostasis1.72043397
40MP0003718_maternal_effect1.70068814
41MP0001905_abnormal_dopamine_level1.68167382
42MP0005083_abnormal_biliary_tract1.66736250
43MP0003186_abnormal_redox_activity1.65153009
44MP0005451_abnormal_body_composition1.64282606
45MP0009379_abnormal_foot_pigmentation1.62400420
46MP0005165_increased_susceptibility_to1.58885964
47MP0002233_abnormal_nose_morphology1.55834367
48MP0004147_increased_porphyrin_level1.55579457
49MP0002877_abnormal_melanocyte_morpholog1.54126803
50MP0004264_abnormal_extraembryonic_tissu1.52772847
51MP0000049_abnormal_middle_ear1.51543899
52MP0002277_abnormal_respiratory_mucosa1.46432268
53MP0009840_abnormal_foam_cell1.44608560
54MP0000477_abnormal_intestine_morphology1.42530354
55MP0005248_abnormal_Harderian_gland1.39470893
56MP0003938_abnormal_ear_development1.36614346
57MP0005166_decreased_susceptibility_to1.36496318
58MP0003646_muscle_fatigue1.35138969
59MP0002136_abnormal_kidney_physiology1.33238682
60MP0000534_abnormal_ureter_morphology1.28729767
61MP0000465_gastrointestinal_hemorrhage1.27251286
62MP0009250_abnormal_appendicular_skeleto1.25493313
63MP0002876_abnormal_thyroid_physiology1.24778559
64MP0001663_abnormal_digestive_system1.21418872
65MP0001984_abnormal_olfaction1.20643137
66MP0006292_abnormal_olfactory_placode1.17947671
67MP0001873_stomach_inflammation1.17513113
68MP0001486_abnormal_startle_reflex1.17337508
69MP0002909_abnormal_adrenal_gland1.15941888
70MP0008004_abnormal_stomach_pH1.13390529
71MP0003191_abnormal_cellular_cholesterol1.12536067
72MP0006082_CNS_inflammation1.12258559
73MP0003693_abnormal_embryo_hatching1.11919186
74MP0000462_abnormal_digestive_system1.11770944
75MP0002282_abnormal_trachea_morphology1.11425855
76MP0008877_abnormal_DNA_methylation1.09352530
77MP0005409_darkened_coat_color1.07526335
78MP0002168_other_aberrant_phenotype1.07099596
79MP0010329_abnormal_lipoprotein_level1.06619248
80MP0008872_abnormal_physiological_respon1.03935592
81MP0002822_catalepsy1.02453138
82MP0010678_abnormal_skin_adnexa1.01787457
83MP0003453_abnormal_keratinocyte_physiol1.01222888
84MP0001849_ear_inflammation0.97824173
85MP0005381_digestive/alimentary_phenotyp0.96940222
86MP0001881_abnormal_mammary_gland0.96905522
87MP0002160_abnormal_reproductive_system0.96470121
88MP0003937_abnormal_limbs/digits/tail_de0.96439139
89MP0004134_abnormal_chest_morphology0.95539049
90MP0003699_abnormal_female_reproductive0.94281685
91MP0004883_abnormal_blood_vessel0.92979467
92MP0010368_abnormal_lymphatic_system0.89040539
93MP0000579_abnormal_nail_morphology0.88867015
94MP0002896_abnormal_bone_mineralization0.88293076
95MP0004133_heterotaxia0.88258209
96MP0004043_abnormal_pH_regulation0.88129218
97MP0003868_abnormal_feces_composition0.87763061
98MP0003755_abnormal_palate_morphology0.87581451
99MP0004782_abnormal_surfactant_physiolog0.87214185
100MP0001119_abnormal_female_reproductive0.86763237
101MP0000681_abnormal_thyroid_gland0.86309960
102MP0002295_abnormal_pulmonary_circulatio0.86050268
103MP0005164_abnormal_response_to0.85867090
104MP0003136_yellow_coat_color0.85333511
105MP0003942_abnormal_urinary_system0.83763721
106MP0005332_abnormal_amino_acid0.82736125
107MP0000383_abnormal_hair_follicle0.81615041
108MP0000653_abnormal_sex_gland0.81280821
109MP0005646_abnormal_pituitary_gland0.80428030
110MP0001756_abnormal_urination0.79703868
111MP0002116_abnormal_craniofacial_bone0.79533843
112MP0001286_abnormal_eye_development0.79131913
113MP0003806_abnormal_nucleotide_metabolis0.78342738
114MP0002118_abnormal_lipid_homeostasis0.78259961
115MP0002177_abnormal_outer_ear0.77719925
116MP0005623_abnormal_meninges_morphology0.77471260
117MP0004742_abnormal_vestibular_system0.77393300
118MP0002166_altered_tumor_susceptibility0.77185992
119MP0001845_abnormal_inflammatory_respons0.76841595
120MP0003303_peritoneal_inflammation0.76403195
121MP0004947_skin_inflammation0.75634830
122MP0003638_abnormal_response/metabolism_0.75504476
123MP0005508_abnormal_skeleton_morphology0.75450511
124MP0003656_abnormal_erythrocyte_physiolo0.75060145
125MP0004270_analgesia0.74895585
126MP0000427_abnormal_hair_cycle0.74534320
127MP0001851_eye_inflammation0.73782209
128MP0002210_abnormal_sex_determination0.73551680
129MP0009384_cardiac_valve_regurgitation0.72806297
130MP0005085_abnormal_gallbladder_physiolo0.72792799
131MP0002098_abnormal_vibrissa_morphology0.71681849
132MP0000467_abnormal_esophagus_morphology0.71295891
133MP0000609_abnormal_liver_physiology0.70985110
134MP0001501_abnormal_sleep_pattern0.68170992
135MP0003115_abnormal_respiratory_system0.67867792
136MP0001502_abnormal_circadian_rhythm0.66590067
137MP0005197_abnormal_uvea_morphology0.65736306
138MP0005388_respiratory_system_phenotype0.65303692
139MP0002133_abnormal_respiratory_system0.65303692
140MP0002060_abnormal_skin_morphology0.65110287
141MP0000490_abnormal_crypts_of0.64963776
142MP0003123_paternal_imprinting0.64856524
143MP0002932_abnormal_joint_morphology0.64607877
144MP0002009_preneoplasia0.64597755
145MP0009053_abnormal_anal_canal0.64523036
146MP0003075_altered_response_to0.63794554
147MP0004484_altered_response_of0.63499421
148MP0005387_immune_system_phenotype0.63480082
149MP0001790_abnormal_immune_system0.63480082
150MP0000647_abnormal_sebaceous_gland0.63086560
151MP0005319_abnormal_enzyme/_coenzyme0.62305474
152MP0002752_abnormal_somatic_nervous0.61842141
153MP0005395_other_phenotype0.61704665
154MP0005310_abnormal_salivary_gland0.61611212
155MP0004381_abnormal_hair_follicle0.61096245
156MP0000627_abnormal_mammary_gland0.60624426
157MP0001340_abnormal_eyelid_morphology0.60620794
158MP0005023_abnormal_wound_healing0.59900649
159MP0002638_abnormal_pupillary_reflex0.59552803
160MP0001216_abnormal_epidermal_layer0.59157667
161MP0000163_abnormal_cartilage_morphology0.59135061
162MP0000538_abnormal_urinary_bladder0.58872418
163MP0000249_abnormal_blood_vessel0.58190995
164MP0001929_abnormal_gametogenesis0.57947568
165MP0005257_abnormal_intraocular_pressure0.57944470
166MP0008995_early_reproductive_senescence0.54851818
167MP0002796_impaired_skin_barrier0.52181705
168MP0003252_abnormal_bile_duct0.50152592

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.49037203
2Absent/shortened dynein arms (HP:0200106)9.49037203
3Nasal polyposis (HP:0100582)6.39748932
4Abnormality of the nasal mucosa (HP:0000433)5.55565752
5Lip pit (HP:0100267)5.48046112
6Abnormal hemoglobin (HP:0011902)4.95840306
7Hyperactive renin-angiotensin system (HP:0000841)4.89103285
8Bronchitis (HP:0012387)4.66106962
9Congenital sensorineural hearing impairment (HP:0008527)4.61958255
10Chronic sinusitis (HP:0011109)4.41100537
11Recurrent sinusitis (HP:0011108)4.09207083
12Infertility (HP:0000789)3.97327202
13Aplasia/Hypoplasia of the fovea (HP:0008060)3.89680816
14Hypoplasia of the fovea (HP:0007750)3.89680816
15Recurrent otitis media (HP:0000403)3.73312102
16Abnormal ciliary motility (HP:0012262)3.59655212
17Abnormal respiratory motile cilium physiology (HP:0012261)3.58748099
18Abnormality of the fovea (HP:0000493)3.50269030
19Chorioretinal atrophy (HP:0000533)3.44936001
20Aplasia involving bones of the extremities (HP:0009825)3.39322087
21Aplasia involving bones of the upper limbs (HP:0009823)3.39322087
22Aplasia of the phalanges of the hand (HP:0009802)3.39322087
23Stomach cancer (HP:0012126)3.35146506
24Decreased circulating renin level (HP:0003351)3.34989891
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.32151302
26Humeroradial synostosis (HP:0003041)3.31575584
27Synostosis involving the elbow (HP:0003938)3.31575584
28Urethral obstruction (HP:0000796)3.21154458
29Chronic otitis media (HP:0000389)3.21105224
30Papillary thyroid carcinoma (HP:0002895)3.12180076
31Mixed hearing impairment (HP:0000410)3.09036790
32Pili torti (HP:0003777)3.05207002
33Periauricular skin pits (HP:0100277)2.98000758
34Preauricular pit (HP:0004467)2.98000758
35Abnormality of cochlea (HP:0000375)2.97623554
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.94098776
37Occipital encephalocele (HP:0002085)2.93391881
38Anomalous pulmonary venous return (HP:0010772)2.85217425
39Male infertility (HP:0003251)2.81646674
40Hepatoblastoma (HP:0002884)2.81161614
41Epiphyseal dysplasia (HP:0002656)2.79147418
42Ventricular fibrillation (HP:0001663)2.76554720
43Malnutrition (HP:0004395)2.70989006
44Popliteal pterygium (HP:0009756)2.70782301
45Stenosis of the external auditory canal (HP:0000402)2.70647127
46Morphological abnormality of the inner ear (HP:0011390)2.68498321
47Atelectasis (HP:0100750)2.67282023
48Abnormality of renin-angiotensin system (HP:0000847)2.67120363
49Abnormal pancreas size (HP:0012094)2.65555427
50Recurrent bronchitis (HP:0002837)2.65362218
51Breast aplasia (HP:0100783)2.65302208
52Arterial tortuosity (HP:0005116)2.63967997
53Down-sloping shoulders (HP:0200021)2.59869477
54Abnormal auditory evoked potentials (HP:0006958)2.58930455
55Renal dysplasia (HP:0000110)2.57255118
56True hermaphroditism (HP:0010459)2.56986397
57Cupped ear (HP:0000378)2.56915058
58Abnormality of the pulmonary veins (HP:0011718)2.55063479
59Abnormality of chloride homeostasis (HP:0011422)2.53648265
60Hypoplastic labia majora (HP:0000059)2.53152542
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.52927278
62Abnormality of the intervertebral disk (HP:0005108)2.52693589
63Aplasia/Hypoplasia of the breasts (HP:0010311)2.50662743
64Abnormality of the labia majora (HP:0012881)2.49744447
65Enlarged epiphyses (HP:0010580)2.49563657
66Hyperkalemia (HP:0002153)2.46870686
67Pancreatic fibrosis (HP:0100732)2.46403332
68Thyroid carcinoma (HP:0002890)2.45240524
69Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.44399937
70Hyperaldosteronism (HP:0000859)2.41822201
71Abnormality of the lacrimal duct (HP:0011481)2.38228472
72Aplasia/Hypoplasia of the macula (HP:0008059)2.37803817
73Neoplasm of the adrenal cortex (HP:0100641)2.37070387
74Acute myeloid leukemia (HP:0004808)2.35833942
75Severe Myopia (HP:0011003)2.35029562
76Flat acetabular roof (HP:0003180)2.32409261
77Prostate neoplasm (HP:0100787)2.32194571
78Increased hepatocellular lipid droplets (HP:0006565)2.32191436
79Nasolacrimal duct obstruction (HP:0000579)2.29092612
80Skin pits (HP:0100276)2.26440430
81Abnormality of monocarboxylic acid metabolism (HP:0010996)2.25795051
82Hypoplastic toenails (HP:0001800)2.25443089
83Cystic liver disease (HP:0006706)2.24656680
84Morphological abnormality of the middle ear (HP:0008609)2.24485680
85Anterior segment dysgenesis (HP:0007700)2.24189342
86Rhinitis (HP:0012384)2.22236279
87Renal salt wasting (HP:0000127)2.22189143
88Vascular tortuosity (HP:0004948)2.21949836
89Absent eyelashes (HP:0000561)2.21875078
90Adrenal hypoplasia (HP:0000835)2.21538551
91Right ventricular cardiomyopathy (HP:0011663)2.21505881
92Distal lower limb muscle weakness (HP:0009053)2.20690294
93Exertional dyspnea (HP:0002875)2.20250806
94Germ cell neoplasia (HP:0100728)2.16616702
95Pulmonary artery stenosis (HP:0004415)2.16413915
96Abnormality of placental membranes (HP:0011409)2.16045862
97Amniotic constriction ring (HP:0009775)2.16045862
98Aplasia/Hypoplasia affecting the retina (HP:0008061)2.15058347
99Abnormality of the distal phalanges of the toes (HP:0010182)2.14364873
100Bifid scrotum (HP:0000048)2.11145993
101Hypoplastic scapulae (HP:0000882)2.10314422
102Aplasia/Hypoplasia of the scapulae (HP:0006713)2.10314422
103Absent eyebrow (HP:0002223)2.09194895
104Genu varum (HP:0002970)2.08903351
105Bronchiectasis (HP:0002110)2.08694639
106Tubulointerstitial nephritis (HP:0001970)2.05203592
107Fat malabsorption (HP:0002630)2.04790565
108Diastasis recti (HP:0001540)2.02876717
109Renal Fanconi syndrome (HP:0001994)2.02674265
110Vitreoretinal degeneration (HP:0000655)2.01703896
111Oligodactyly (HP:0012165)1.97338204
112Abnormality of proline metabolism (HP:0010907)1.96677336
113Hydroxyprolinuria (HP:0003080)1.96677336
114Abnormality of the renal medulla (HP:0100957)1.96107278
115Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.95422941
116Pancreatic cysts (HP:0001737)1.93612778
117Chronic bronchitis (HP:0004469)1.93050392
118Abnormal vertebral ossification (HP:0100569)1.92231117
119Chromsome breakage (HP:0040012)1.91283529
120Renal tubular acidosis (HP:0001947)1.89817315
121Hyponatremia (HP:0002902)1.89161622
122Median cleft lip (HP:0000161)1.89052398
123Bell-shaped thorax (HP:0001591)1.85658660
124Abnormality of the labia (HP:0000058)1.85625228
125Abnormal respiratory epithelium morphology (HP:0012253)1.85000387
126Abnormal respiratory motile cilium morphology (HP:0005938)1.85000387
127Interstitial pulmonary disease (HP:0006530)1.84844297
128Abnormality of the pubic bones (HP:0003172)1.84482566
129Lipid accumulation in hepatocytes (HP:0006561)1.83592563
130Abnormality of the nasolacrimal system (HP:0000614)1.83393407
131Upper limb muscle weakness (HP:0003484)1.83378318
132Hypoplastic ischia (HP:0003175)1.83095079
133Aplasia/Hypoplasia of the sternum (HP:0006714)1.82498298
134Oral leukoplakia (HP:0002745)1.82311828
135Chronic hepatic failure (HP:0100626)1.82076583
136Alkalosis (HP:0001948)1.74448401
137Abnormality of midbrain morphology (HP:0002418)1.72252754
138Molar tooth sign on MRI (HP:0002419)1.72252754
139Nephronophthisis (HP:0000090)1.68567606
140Postaxial foot polydactyly (HP:0001830)1.65784122
141Abnormal glucose tolerance (HP:0001952)1.64685592
142Systemic lupus erythematosus (HP:0002725)1.62768316
143Cone-rod dystrophy (HP:0000548)1.62323179
144Hypotension (HP:0002615)1.60138599
145Chronic diarrhea (HP:0002028)1.55581063
146Male pseudohermaphroditism (HP:0000037)1.52846230
147Steatorrhea (HP:0002570)1.48062717
148Tubular atrophy (HP:0000092)1.47859150
149Glucose intolerance (HP:0000833)1.47132782
150Abnormality of sodium homeostasis (HP:0010931)1.47114449
151Nephropathy (HP:0000112)1.47050891
152Congenital hepatic fibrosis (HP:0002612)1.46868223
153Abnormality of vitamin metabolism (HP:0100508)1.45066049
154Absent frontal sinuses (HP:0002688)1.44844832
155Vascular calcification (HP:0004934)1.44657989
156Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.41031944
157Furrowed tongue (HP:0000221)1.39985068
158Asplenia (HP:0001746)1.39750386
159Hand muscle atrophy (HP:0009130)1.37909424
160Adrenal overactivity (HP:0002717)1.36649563
161Aplasia/Hypoplasia of the tongue (HP:0010295)1.35439360
162Glomerulonephritis (HP:0000099)1.35097069
163Aplasia/Hypoplasia of the spleen (HP:0010451)1.34967551
164Ileus (HP:0002595)1.34843555
165Pigmentary retinal degeneration (HP:0001146)1.33905608
166Abnormality of permanent molar morphology (HP:0011071)1.33072389
167Abnormality of the dental root (HP:0006486)1.33072389
168Taurodontia (HP:0000679)1.33072389
169Short nail (HP:0001799)1.32901839
170Alveolar cell carcinoma (HP:0006519)1.31952304
171Spinal cord compression (HP:0002176)1.29389048
172Growth hormone excess (HP:0000845)1.28416451
173Tubulointerstitial fibrosis (HP:0005576)1.26621200
174Aplasia of the musculature (HP:0100854)1.26164662
175Abnormality of potassium homeostasis (HP:0011042)1.25667469
176Metabolic alkalosis (HP:0200114)1.25202035
177Cardiovascular calcification (HP:0011915)1.25138955
178Anencephaly (HP:0002323)1.24401753
179Abnormality of the dental pulp (HP:0006479)1.22742660
180Absent rod-and cone-mediated responses on ERG (HP:0007688)1.22565109
181Dehydration (HP:0001944)1.22067107
182Abnormality of molar (HP:0011077)1.21284540
183Abnormality of molar morphology (HP:0011070)1.21284540
184Hypokalemic alkalosis (HP:0001949)1.20610997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR24.63429661
2PBK4.03031575
3ERBB33.64412770
4DDR23.59326584
5LATS13.14473940
6ERBB43.03659992
7STK38L2.97577848
8FER2.64105862
9ACVR1B2.57676300
10TTK2.57262085
11RPS6KB22.17398168
12EPHA22.09516459
13PLK42.05827456
14FRK2.04577904
15RIPK12.03883130
16MAP3K92.02794084
17TRPM71.95726089
18STK241.89322039
19MAP3K61.81368414
20HIPK21.78411249
21LATS21.76156749
22ERN11.73661432
23NUAK11.73212472
24MAP3K31.67470172
25MST41.64825448
26MAPK151.57776780
27MKNK21.57382520
28MUSK1.57242610
29MAPKAPK31.56320036
30MAPKAPK51.52430957
31NEK91.51003101
32MAP3K21.49399325
33LRRK21.49244752
34LMTK21.44498113
35CSNK1A1L1.42379796
36BRAF1.36548456
37ZAK1.35171070
38PRKG21.32929983
39BRSK21.29567578
40EEF2K1.29333608
41SMG11.28779754
42STK391.26023121
43KSR21.24643288
44MET1.24437086
45PIK3CA1.23095014
46TAOK11.19268783
47NME11.17697340
48MAP2K21.12638972
49FGFR41.12342809
50EPHA31.11477212
51NLK1.11009183
52OXSR11.10088660
53GRK61.06607858
54PRKD31.03530305
55MYLK1.00216313
56CSNK1G10.99697830
57MAP3K120.96997921
58STK100.96828252
59CSK0.96492540
60TBK10.95416924
61EPHB10.93160664
62PTK20.92503731
63MAP3K130.91429122
64PTK60.91106093
65TRIB30.90946567
66CHEK20.90570631
67CSNK1G30.88957983
68AURKB0.85968313
69MOS0.85492067
70BMPR1B0.84723467
71ERBB20.83660443
72STK30.83289194
73TYK20.82853622
74FGFR30.82528189
75EPHB20.80155700
76PLK10.79118432
77IRAK10.77856953
78TAOK30.77360578
79RIPK40.75118284
80CDK80.74885345
81PRKCI0.74419737
82MAP2K60.72303071
83MELK0.70184756
84STK380.68274099
85MKNK10.68002051
86BCR0.66207073
87TESK10.65131369
88CSNK1G20.64765711
89PAK40.62750000
90PAK30.62166873
91CDK60.61398472
92AKT30.60853830
93TLK10.60488020
94MAP2K10.60273136
95IKBKE0.59980296
96PDPK10.59691640
97RPS6KA20.58658311
98AURKA0.58320915
99CAMK2B0.55420350
100DYRK20.54930649
101NEK20.54799236
102CAMK2G0.51114523
103PLK30.50752059
104PRKAA20.49531311
105WNK40.49173239
106LIMK10.47779012
107MAP3K70.47056265
108NTRK20.45531061
109NEK60.45351601
110ZAP700.44489272
111GRK10.43558179
112STK40.42888786
113CAMK2D0.42215737
114PRKCD0.42035977
115MATK0.40372777
116CDC42BPA0.40134267
117ARAF0.39676431
118CAMK2A0.39515862
119PTK2B0.37885369
120YES10.37816547
121VRK10.37308968
122RET0.34215516
123ICK0.34132232
124DAPK20.33378133
125PRKCQ0.33156647
126SRC0.32959960
127RPS6KA10.32564950
128PRKCA0.32438601
129MAP3K10.32152541
130PAK10.31955243
131DYRK1B0.31832329
132CDK90.31417221
133MAPK130.31392557
134MST1R0.31307795
135ABL10.30078555
136AKT20.29916666
137MAP3K80.28228871
138RPS6KA40.27790701
139ABL20.26837013
140MARK20.26715550
141PRKD10.26425786
142CDK120.25736161
143KSR10.25544820
144MAPKAPK20.24652662
145PRKCZ0.24188999
146IGF1R0.23969638
147JAK10.23570066
148INSRR0.23324460
149CHUK0.23000878
150RAF10.22716354
151ATM0.22147302
152PDK10.19802641
153MAP3K100.15953070
154ROCK10.15651786

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.65841914
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.61216882
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.50754808
4Chemical carcinogenesis_Homo sapiens_hsa052043.90733188
5Pentose and glucuronate interconversions_Homo sapiens_hsa000403.87104671
6Cyanoamino acid metabolism_Homo sapiens_hsa004603.39508571
7Phenylalanine metabolism_Homo sapiens_hsa003603.20302047
8Glutathione metabolism_Homo sapiens_hsa004803.05266819
9Vitamin digestion and absorption_Homo sapiens_hsa049772.52762631
10Tyrosine metabolism_Homo sapiens_hsa003502.37194293
11Retinol metabolism_Homo sapiens_hsa008302.36265034
12Fat digestion and absorption_Homo sapiens_hsa049752.22403556
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.06394444
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.85093237
15Sulfur metabolism_Homo sapiens_hsa009201.78744957
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74006746
17Renin-angiotensin system_Homo sapiens_hsa046141.72013913
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71303241
19Notch signaling pathway_Homo sapiens_hsa043301.64649710
20RNA degradation_Homo sapiens_hsa030181.59332598
21Circadian rhythm_Homo sapiens_hsa047101.54115150
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.51843446
23Sphingolipid metabolism_Homo sapiens_hsa006001.50800202
24Fatty acid degradation_Homo sapiens_hsa000711.48194967
25Tight junction_Homo sapiens_hsa045301.47146522
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43149758
27Fructose and mannose metabolism_Homo sapiens_hsa000511.40981287
28Linoleic acid metabolism_Homo sapiens_hsa005911.40892598
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.39942738
30Histidine metabolism_Homo sapiens_hsa003401.38268510
31Ovarian steroidogenesis_Homo sapiens_hsa049131.35388716
32TGF-beta signaling pathway_Homo sapiens_hsa043501.31791881
33Arginine biosynthesis_Homo sapiens_hsa002201.29728790
34Hippo signaling pathway_Homo sapiens_hsa043901.26933600
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25912704
36PPAR signaling pathway_Homo sapiens_hsa033201.23255620
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23072930
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20114036
39Arachidonic acid metabolism_Homo sapiens_hsa005901.19237085
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19032463
41Bile secretion_Homo sapiens_hsa049761.18507328
42Prolactin signaling pathway_Homo sapiens_hsa049171.11440316
43Cell cycle_Homo sapiens_hsa041101.08320898
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.08160182
45African trypanosomiasis_Homo sapiens_hsa051431.06359454
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05035724
47beta-Alanine metabolism_Homo sapiens_hsa004101.02417752
48GnRH signaling pathway_Homo sapiens_hsa049121.01350434
49Bladder cancer_Homo sapiens_hsa052191.00326382
50Pancreatic secretion_Homo sapiens_hsa049720.99709522
51Adherens junction_Homo sapiens_hsa045200.95176594
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90586593
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88328927
54Arginine and proline metabolism_Homo sapiens_hsa003300.88112864
55Pancreatic cancer_Homo sapiens_hsa052120.87404517
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87398954
57Basal cell carcinoma_Homo sapiens_hsa052170.87064136
58ABC transporters_Homo sapiens_hsa020100.86314719
59Starch and sucrose metabolism_Homo sapiens_hsa005000.85901334
60Vitamin B6 metabolism_Homo sapiens_hsa007500.85724959
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84925591
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.82845106
63Asthma_Homo sapiens_hsa053100.82190966
64Mineral absorption_Homo sapiens_hsa049780.80557456
65Galactose metabolism_Homo sapiens_hsa000520.80398419
66Hepatitis C_Homo sapiens_hsa051600.79461225
67Graft-versus-host disease_Homo sapiens_hsa053320.79130081
68Thyroid hormone synthesis_Homo sapiens_hsa049180.79013122
69Nitrogen metabolism_Homo sapiens_hsa009100.78647147
70TNF signaling pathway_Homo sapiens_hsa046680.77106510
71Sulfur relay system_Homo sapiens_hsa041220.76679400
72Ether lipid metabolism_Homo sapiens_hsa005650.73880721
73Tryptophan metabolism_Homo sapiens_hsa003800.73590566
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71731546
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71502292
76MicroRNAs in cancer_Homo sapiens_hsa052060.70556023
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67713996
78Huntingtons disease_Homo sapiens_hsa050160.66176654
79Thyroid cancer_Homo sapiens_hsa052160.65935361
80Colorectal cancer_Homo sapiens_hsa052100.65891980
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65005391
82Gastric acid secretion_Homo sapiens_hsa049710.64872051
83Inositol phosphate metabolism_Homo sapiens_hsa005620.64609516
84Protein digestion and absorption_Homo sapiens_hsa049740.64291294
85Glycerolipid metabolism_Homo sapiens_hsa005610.63953440
86FoxO signaling pathway_Homo sapiens_hsa040680.63109027
87Caffeine metabolism_Homo sapiens_hsa002320.61364878
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61354686
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.60723484
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.60545034
91ECM-receptor interaction_Homo sapiens_hsa045120.57781010
92Fanconi anemia pathway_Homo sapiens_hsa034600.57644184
93Staphylococcus aureus infection_Homo sapiens_hsa051500.57396048
94Allograft rejection_Homo sapiens_hsa053300.57081845
95Malaria_Homo sapiens_hsa051440.56744752
96Endometrial cancer_Homo sapiens_hsa052130.55668998
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54317415
98Autoimmune thyroid disease_Homo sapiens_hsa053200.53351908
99Prion diseases_Homo sapiens_hsa050200.50950403
100Wnt signaling pathway_Homo sapiens_hsa043100.50920671
101Lysine degradation_Homo sapiens_hsa003100.50710214
102Melanoma_Homo sapiens_hsa052180.50252760
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.49957528
104Homologous recombination_Homo sapiens_hsa034400.49033605
105Ribosome_Homo sapiens_hsa030100.48649435
106Basal transcription factors_Homo sapiens_hsa030220.47190192
107Melanogenesis_Homo sapiens_hsa049160.47101413
108Hepatitis B_Homo sapiens_hsa051610.45962201
109Mismatch repair_Homo sapiens_hsa034300.44903363
110Other glycan degradation_Homo sapiens_hsa005110.44430481
111Complement and coagulation cascades_Homo sapiens_hsa046100.43796198
112Type I diabetes mellitus_Homo sapiens_hsa049400.42528899
113Prostate cancer_Homo sapiens_hsa052150.41985753
114Amoebiasis_Homo sapiens_hsa051460.41623163
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.41500012
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40051017
117p53 signaling pathway_Homo sapiens_hsa041150.39614738
118Folate biosynthesis_Homo sapiens_hsa007900.37472695
119Choline metabolism in cancer_Homo sapiens_hsa052310.37439634
120Influenza A_Homo sapiens_hsa051640.36182404
121Pathways in cancer_Homo sapiens_hsa052000.35898076
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.35566587
123Peroxisome_Homo sapiens_hsa041460.35406141
124Pertussis_Homo sapiens_hsa051330.35112324
125Insulin resistance_Homo sapiens_hsa049310.35057900
126mRNA surveillance pathway_Homo sapiens_hsa030150.35025751
127Lysosome_Homo sapiens_hsa041420.34846041
128HTLV-I infection_Homo sapiens_hsa051660.34428548
129Salivary secretion_Homo sapiens_hsa049700.34009436
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33100799
131Chronic myeloid leukemia_Homo sapiens_hsa052200.32244997
132Dorso-ventral axis formation_Homo sapiens_hsa043200.32143925
133Estrogen signaling pathway_Homo sapiens_hsa049150.31477607
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31308707
135Antigen processing and presentation_Homo sapiens_hsa046120.30762980
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30525642
137Small cell lung cancer_Homo sapiens_hsa052220.30180968
138Long-term depression_Homo sapiens_hsa047300.28833831
139Axon guidance_Homo sapiens_hsa043600.27850152
140Metabolic pathways_Homo sapiens_hsa011000.25131935
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25103970
142Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24120204
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23145731
144Hematopoietic cell lineage_Homo sapiens_hsa046400.22943235
145Fatty acid biosynthesis_Homo sapiens_hsa000610.22101915
146Fatty acid metabolism_Homo sapiens_hsa012120.20298766
147Vibrio cholerae infection_Homo sapiens_hsa051100.18512626
148N-Glycan biosynthesis_Homo sapiens_hsa005100.12801460
149Fatty acid elongation_Homo sapiens_hsa000620.12699060
150Renin secretion_Homo sapiens_hsa049240.12066515
151Phagosome_Homo sapiens_hsa041450.10089414
152Endocytosis_Homo sapiens_hsa041440.06430544
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.05077312

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