AGRP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1labyrinthine layer development (GO:0060711)9.92055028
2regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033398.64434230
3melanin biosynthetic process (GO:0042438)7.47024023
4negative regulation of metanephros development (GO:0072217)7.32845465
5neuromuscular process controlling posture (GO:0050884)6.93635341
6neuronal action potential propagation (GO:0019227)6.80288360
7melanin metabolic process (GO:0006582)6.52791982
8cellular response to follicle-stimulating hormone stimulus (GO:0071372)6.45739702
9respiratory system process (GO:0003016)6.15659692
10secondary metabolite biosynthetic process (GO:0044550)6.00404091
11C21-steroid hormone biosynthetic process (GO:0006700)5.84736642
12response to pheromone (GO:0019236)5.79906217
13glycosphingolipid catabolic process (GO:0046479)5.63345894
14locomotory exploration behavior (GO:0035641)5.13035395
15detection of molecule of bacterial origin (GO:0032490)5.11590355
16cellular extravasation (GO:0045123)5.07659191
17glycolipid catabolic process (GO:0019377)5.04001924
18progesterone metabolic process (GO:0042448)5.02723571
19SMAD protein signal transduction (GO:0060395)4.96295334
20oligosaccharide catabolic process (GO:0009313)4.92878979
21cellular response to antibiotic (GO:0071236)4.91024927
22axonal fasciculation (GO:0007413)4.90551493
23mesenchymal to epithelial transition (GO:0060231)4.85265311
24glucocorticoid biosynthetic process (GO:0006704)4.76523228
25amino sugar catabolic process (GO:0046348)4.74471800
26synaptic vesicle maturation (GO:0016188)4.73038387
27neutrophil activation involved in immune response (GO:0002283)4.62547907
28response to follicle-stimulating hormone (GO:0032354)4.56736541
29estrogen biosynthetic process (GO:0006703)4.52122186
30myotube differentiation (GO:0014902)4.43483290
31ceramide catabolic process (GO:0046514)4.41073531
32glucocorticoid metabolic process (GO:0008211)4.40057750
33motile cilium assembly (GO:0044458)4.36788128
34regulation of cholesterol storage (GO:0010885)4.31424482
35detection of external biotic stimulus (GO:0098581)4.29482878
36regulation of glutamate secretion (GO:0014048)4.23217372
37androgen biosynthetic process (GO:0006702)4.22714467
38negative regulation of kidney development (GO:0090185)4.18669060
39positive regulation of gamma-delta T cell activation (GO:0046645)4.14680071
40synaptic vesicle exocytosis (GO:0016079)4.13329099
41positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.09349581
42detection of other organism (GO:0098543)3.98027344
43C21-steroid hormone metabolic process (GO:0008207)3.93540436
44ribosomal large subunit biogenesis (GO:0042273)3.88499536
45response to interleukin-6 (GO:0070741)3.85091042
46detection of biotic stimulus (GO:0009595)3.81537274
47* adult feeding behavior (GO:0008343)3.80939537
48negative regulation of interleukin-12 production (GO:0032695)3.77940971
49response to peptidoglycan (GO:0032494)3.77150459
50positive regulation of mast cell activation (GO:0033005)3.71719819
51drinking behavior (GO:0042756)3.70959091
52low-density lipoprotein particle clearance (GO:0034383)3.70097276
53positive regulation of mast cell degranulation (GO:0043306)3.68941364
54positive regulation of mast cell activation involved in immune response (GO:0033008)3.68941364
55activation of protein kinase A activity (GO:0034199)3.64659079
56transmission of nerve impulse (GO:0019226)3.60377503
57positive regulation of vesicle fusion (GO:0031340)3.59866325
58regulation of collateral sprouting (GO:0048670)3.59324924
59detection of bacterium (GO:0016045)3.59224496
60regulation of synaptic vesicle exocytosis (GO:2000300)3.54892433
61regulation of vesicle fusion (GO:0031338)3.52506259
62regulation of mononuclear cell migration (GO:0071675)3.51366536
63cellular response to gonadotropin stimulus (GO:0071371)3.50470748
64cellular protein complex localization (GO:0034629)3.49906815
65respiratory burst (GO:0045730)3.48728325
66macrophage activation involved in immune response (GO:0002281)3.47361637
67neurotransmitter secretion (GO:0007269)3.46503548
68negative regulation of T cell receptor signaling pathway (GO:0050860)3.45738044
69response to insecticide (GO:0017085)3.43604605
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.42505869
71cellular response to cadmium ion (GO:0071276)3.41750674
72positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.39790870
73positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.36288225
74regulation of mast cell degranulation (GO:0043304)3.35917684
75negative regulation of neurotransmitter secretion (GO:0046929)3.34793578
76neuron cell-cell adhesion (GO:0007158)3.33788921
77cellular response to epinephrine stimulus (GO:0071872)3.33770211
78N-acetylneuraminate metabolic process (GO:0006054)3.32969014
79response to dietary excess (GO:0002021)3.32835945
80cellular response to thyroid hormone stimulus (GO:0097067)3.31036728
81positive regulation of leukocyte degranulation (GO:0043302)3.30117728
82modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.28635600
83positive regulation by organism of defense response of other organism involved in symbiotic interact3.28635600
84modulation by symbiont of host immune response (GO:0052553)3.28635600
85positive regulation by symbiont of host defense response (GO:0052509)3.28635600
86modulation by symbiont of host defense response (GO:0052031)3.28635600
87modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.28635600
88vitamin D metabolic process (GO:0042359)3.28096034
89cellular response to toxic substance (GO:0097237)3.27246617
90gamma-aminobutyric acid transport (GO:0015812)3.25610347
91immunoglobulin mediated immune response (GO:0016064)3.25247328
92positive regulation of cellular amide metabolic process (GO:0034250)3.24953324
93Rap protein signal transduction (GO:0032486)3.24097499
94positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.19788573
95viral transcription (GO:0019083)3.19452576
96negative regulation of protein autophosphorylation (GO:0031953)3.17263402
97negative regulation of amino acid transport (GO:0051956)3.17158590
98lipopolysaccharide-mediated signaling pathway (GO:0031663)3.16032882
99protein-cofactor linkage (GO:0018065)3.14922493
100regulation of myeloid leukocyte mediated immunity (GO:0002886)3.13224681
101detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.12456780
102translational termination (GO:0006415)3.10746374
103regulation of leukocyte degranulation (GO:0043300)3.10262842
104regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.10068944
105positive regulation of bone resorption (GO:0045780)3.09670038
106positive regulation of bone remodeling (GO:0046852)3.09670038
107regulation of mast cell activation (GO:0033003)3.08882810
108neutrophil chemotaxis (GO:0030593)3.07654678
109neuron recognition (GO:0008038)3.06989916
110negative regulation of catecholamine secretion (GO:0033604)3.05915057
111regulation of mast cell activation involved in immune response (GO:0033006)3.04930303
112granulocyte activation (GO:0036230)3.04139058
113regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.03259235
114negative regulation of macrophage differentiation (GO:0045650)3.02116362
115glucosamine-containing compound catabolic process (GO:1901072)3.01429376
116neutrophil migration (GO:1990266)3.00644739
117negative regulation of cell killing (GO:0031342)2.98792716
118negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.98792716
119regulation of macrophage chemotaxis (GO:0010758)2.98326043
120neurotransmitter catabolic process (GO:0042135)2.98319071
121cytokine metabolic process (GO:0042107)2.97744355
122negative regulation of amine transport (GO:0051953)2.97691127
123regulation of B cell receptor signaling pathway (GO:0050855)2.96886148
124positive regulation of action potential (GO:0045760)2.96852175
125melanocyte differentiation (GO:0030318)2.95513122
126regulation of metanephros development (GO:0072215)2.95159222
127cholesterol efflux (GO:0033344)2.94172658
128phagosome maturation (GO:0090382)2.93423962
129L-amino acid import (GO:0043092)2.92959691
130positive regulation of monocyte chemotaxis (GO:0090026)2.91772457
131macrophage activation (GO:0042116)2.91276058
132sphingolipid catabolic process (GO:0030149)2.90386803
133plasma lipoprotein particle clearance (GO:0034381)2.89922604
134production of molecular mediator involved in inflammatory response (GO:0002532)2.89186968
135myeloid dendritic cell differentiation (GO:0043011)2.88129796
136very-low-density lipoprotein particle assembly (GO:0034379)2.87104694
137positive regulation of B cell differentiation (GO:0045579)2.87074285
138glutamate secretion (GO:0014047)2.85208225
139regulation of monocyte differentiation (GO:0045655)2.84946473
140neutrophil activation (GO:0042119)2.84856750
141granulocyte chemotaxis (GO:0071621)2.84446534
142response to thyroid hormone (GO:0097066)2.84225656
143phenol-containing compound biosynthetic process (GO:0046189)2.84042059
144gamma-aminobutyric acid signaling pathway (GO:0007214)2.82538526
145pigment cell differentiation (GO:0050931)2.82359771
146Leydig cell differentiation (GO:0033327)2.81781931
147regulation of short-term neuronal synaptic plasticity (GO:0048172)2.81033152
148regulation of cholesterol homeostasis (GO:2000188)2.80961426
149regulation of interferon-beta biosynthetic process (GO:0045357)2.80382206
150myeloid dendritic cell activation (GO:0001773)2.80052388
151calcium-mediated signaling using intracellular calcium source (GO:0035584)2.79388400
152positive regulation of hormone biosynthetic process (GO:0046886)2.78444405
153membrane lipid catabolic process (GO:0046466)2.78408962
154peptide catabolic process (GO:0043171)2.77786223
155cerebellar Purkinje cell layer development (GO:0021680)2.77288084
156regulation of hypersensitivity (GO:0002883)2.76919691
157glial cell migration (GO:0008347)2.76690591
158granulocyte migration (GO:0097530)2.76333766
159microglial cell activation (GO:0001774)2.76070819
160regulation of synaptic vesicle transport (GO:1902803)2.72555252
161regulation of beta-amyloid formation (GO:1902003)2.72409644
162regulation of transmission of nerve impulse (GO:0051969)2.71693616
163exploration behavior (GO:0035640)2.71352452
164neuronal ion channel clustering (GO:0045161)2.70362568
165regulation of amyloid precursor protein catabolic process (GO:1902991)2.69142830
166ribosomal small subunit biogenesis (GO:0042274)2.67674097
167detection of chemical stimulus involved in sensory perception (GO:0050907)2.64221148
168ribosomal small subunit assembly (GO:0000028)2.63293429
169organelle transport along microtubule (GO:0072384)2.62742706
170mitochondrion transport along microtubule (GO:0047497)2.62671184
171establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62671184
172establishment of melanosome localization (GO:0032401)2.62310517
173viral life cycle (GO:0019058)2.60423947
174melanosome transport (GO:0032402)2.60103109
175layer formation in cerebral cortex (GO:0021819)2.55616595
176* regulation of feeding behavior (GO:0060259)2.55239753
177establishment of mitochondrion localization (GO:0051654)2.54663940
178cerebellar granule cell differentiation (GO:0021707)2.54180302
179neurotransmitter transport (GO:0006836)2.53630831
180maturation of SSU-rRNA (GO:0030490)2.53606474
181cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.53530525
182auditory receptor cell stereocilium organization (GO:0060088)2.53196844
183protein palmitoylation (GO:0018345)2.52946383
184Golgi to plasma membrane protein transport (GO:0043001)2.52487304
185cellular protein complex disassembly (GO:0043624)2.52277953
186C4-dicarboxylate transport (GO:0015740)2.50725072
187negative regulation of cell morphogenesis involved in differentiation (GO:0010771)2.47562758
188sulfur amino acid catabolic process (GO:0000098)2.46736536
189nerve growth factor signaling pathway (GO:0038180)2.46630008
190pigmentation (GO:0043473)2.45377088
191anatomical structure maturation (GO:0071695)2.44143875
192response to interleukin-4 (GO:0070670)2.43821158
193negative regulation of neurotransmitter transport (GO:0051589)2.42827963
194establishment of pigment granule localization (GO:0051905)2.42125856
195melanosome localization (GO:0032400)2.41650299
196regulation of norepinephrine secretion (GO:0014061)2.41440895
197adult walking behavior (GO:0007628)2.41155045
198response to parathyroid hormone (GO:0071107)13.2957717

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse5.91202016
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.24246372
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.05290711
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.55100742
5EZH2_22144423_ChIP-Seq_EOC_Human4.50163536
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human4.09702333
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.03757882
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.77240525
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.62557837
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.55652525
11ZNF263_19887448_ChIP-Seq_K562_Human3.48678831
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.45278159
13SCL_19346495_ChIP-Seq_HPC-7_Human3.25162612
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10533919
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98267226
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.95345965
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.85913672
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.68903859
19VDR_21846776_ChIP-Seq_THP-1_Human2.61505555
20VDR_24763502_ChIP-Seq_THP-1_Human2.60102287
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59522011
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.49012959
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.44031797
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42159466
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.40753037
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.40473552
27SPI1_23547873_ChIP-Seq_NB4_Human2.38632572
28TRIM28_21343339_ChIP-Seq_HEK293_Human2.37690578
29BRD4_27068464_Chip-Seq_AML-cells_Mouse2.29728933
30REST_21632747_ChIP-Seq_MESCs_Mouse2.28715603
31VDR_24787735_ChIP-Seq_THP-1_Human2.23955246
32SPI1_23127762_ChIP-Seq_K562_Human2.23784221
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19856305
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.15216551
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14567604
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06658381
37MYC_22102868_ChIP-Seq_BL_Human2.05914895
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03112887
39RUNX1_22412390_ChIP-Seq_EML_Mouse2.03036129
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00856185
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00051935
42* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98049350
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.96808332
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95756874
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95756874
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92853989
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89624323
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89463706
49EGR1_19032775_ChIP-ChIP_M12_Human1.84248014
50DROSHA_22980978_ChIP-Seq_HELA_Human1.84199615
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83994186
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81730387
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.81673035
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77908212
55* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77295704
56* EZH2_27294783_Chip-Seq_ESCs_Mouse1.77198649
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.75489161
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75442780
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75424009
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.74299987
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74064992
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73687484
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.72023466
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71006513
65ZNF274_21170338_ChIP-Seq_K562_Hela1.70713326
66UTX_26944678_Chip-Seq_JUKART_Human1.66784531
67DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.66722542
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.65028268
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64582360
70MAF_26560356_Chip-Seq_TH1_Human1.64412009
71RUNX_20019798_ChIP-Seq_JUKART_Human1.63465129
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62080385
73CTCF_27219007_Chip-Seq_Bcells_Human1.59394057
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59222561
75SA1_27219007_Chip-Seq_Bcells_Human1.58412486
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58217159
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.57716083
78SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55151736
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.54800994
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54515893
81TP53_20018659_ChIP-ChIP_R1E_Mouse1.52684512
82RARB_27405468_Chip-Seq_BRAIN_Mouse1.52417579
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51200654
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49309077
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49251339
86KDM2B_26808549_Chip-Seq_DND41_Human1.47360837
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46649528
88TFEB_21752829_ChIP-Seq_HELA_Human1.45916091
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44320454
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43350636
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42483047
92GATA1_19941826_ChIP-Seq_K562_Human1.41380538
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.41199795
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40548726
95PU_27001747_Chip-Seq_BMDM_Mouse1.38161608
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.38148301
97GATA1_22025678_ChIP-Seq_K562_Human1.36283260
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35523916
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35303824
100TCF7_22412390_ChIP-Seq_EML_Mouse1.35055391
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34386347
102MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.33840709
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32647359
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32386847
105CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32055525
106LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31131747
107EGR1_19374776_ChIP-ChIP_THP-1_Human1.30917612
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30412813
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29822826
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28334146
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28132171
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27794570
113RNF2_27304074_Chip-Seq_ESCs_Mouse1.27768960
114MYB_26560356_Chip-Seq_TH2_Human1.27768777
115DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26446739
116FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24779678
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23906700
118PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22940704
119ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22906824
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18436197
121NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16148789
122CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15715805
123KDM2B_26808549_Chip-Seq_K562_Human1.14407420
124CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14082123
125GATA3_27048872_Chip-Seq_THYMUS_Human1.12813078
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11619802
127TET1_21490601_ChIP-Seq_MESCs_Mouse1.11504190
128CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11403582
129AR_21572438_ChIP-Seq_LNCaP_Human1.10269239
130GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09701164
131MYB_26560356_Chip-Seq_TH1_Human1.08582710
132NCOR1_26117541_ChIP-Seq_K562_Human1.08456036
133BCOR_27268052_Chip-Seq_Bcells_Human1.07619022
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07570464
135KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07079751
136* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06883658
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06723314
138CLOCK_20551151_ChIP-Seq_293T_Human1.06197831
139RING1B_27294783_Chip-Seq_ESCs_Mouse1.05532256
140ELK3_25401928_ChIP-Seq_HUVEC_Human1.04858901
141MAF_26560356_Chip-Seq_TH2_Human1.01836841
142EOMES_21245162_ChIP-Seq_HESCs_Human1.01171734
143CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01140939
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00737302
145SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00260569
146TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99755555
147* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99682566
148GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99545319
149ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99311505
150SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99050003
151CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98615608
152TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98353537
153RING1B_27294783_Chip-Seq_NPCs_Mouse0.97825999
154CREB1_26743006_Chip-Seq_LNCaP_Human0.96324855
155CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96315017
156PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95685635
157ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93428503
158BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93201500
159ESR2_21235772_ChIP-Seq_MCF-7_Human0.93184642
160* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92769328
161GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91685262
162BCL6_27268052_Chip-Seq_Bcells_Human0.91576361
163ELF1_20517297_ChIP-Seq_JURKAT_Human0.90941589
164GATA2_19941826_ChIP-Seq_K562_Human0.90913440
165* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88916153
166LXR_22292898_ChIP-Seq_THP-1_Human0.87772569
167TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87702944
168CTCF_20526341_ChIP-Seq_ESCs_Human0.87693965
169PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87361098
170HTT_18923047_ChIP-ChIP_STHdh_Human0.86962281
171CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86451899
172KDM2B_26808549_Chip-Seq_JURKAT_Human0.86434512
173OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84204798
174TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83694348
175POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83694348
176CREB1_15753290_ChIP-ChIP_HEK293T_Human0.83339502
177EP300_21415370_ChIP-Seq_HL-1_Mouse0.82922144
178ESR1_20079471_ChIP-ChIP_T-47D_Human0.82456199
179CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81466327
180THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80564499
181RACK7_27058665_Chip-Seq_MCF-7_Human0.79909588
182SMAD3_21741376_ChIP-Seq_EPCs_Human0.78115796
183SMC4_20622854_ChIP-Seq_HELA_Human0.76180445
184P300_19829295_ChIP-Seq_ESCs_Human0.74630968
185SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74533586
186PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.74499608
187EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.73410145
188MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73241077
189TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72483361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting9.26975861
2MP0003122_maternal_imprinting6.07459805
3MP0005423_abnormal_somatic_nervous5.30942305
4MP0003121_genomic_imprinting5.01977010
5MP0001986_abnormal_taste_sensitivity4.45947305
6MP0003191_abnormal_cellular_cholesterol3.86605340
7MP0006276_abnormal_autonomic_nervous3.61648701
8MP0000604_amyloidosis3.59064373
9MP0003172_abnormal_lysosome_physiology3.30712035
10MP0005645_abnormal_hypothalamus_physiol3.11106015
11MP0003724_increased_susceptibility_to2.86523135
12MP0006082_CNS_inflammation2.85813085
13MP0002419_abnormal_innate_immunity2.79256700
14MP0003303_peritoneal_inflammation2.71761614
15MP0001440_abnormal_grooming_behavior2.70812154
16MP0003436_decreased_susceptibility_to2.54766565
17MP0000569_abnormal_digit_pigmentation2.52832043
18MP0001835_abnormal_antigen_presentation2.41516103
19MP0005623_abnormal_meninges_morphology2.34082862
20MP0002148_abnormal_hypersensitivity_rea2.28314636
21MP0005025_abnormal_response_to2.21271061
22MP0008995_early_reproductive_senescence2.19523682
23MP0002064_seizures2.14926595
24MP0000427_abnormal_hair_cycle2.14517619
25MP0005387_immune_system_phenotype2.10500259
26MP0001790_abnormal_immune_system2.10500259
27MP0005671_abnormal_response_to2.09906354
28* MP0003635_abnormal_synaptic_transmissio2.07337620
29MP0004859_abnormal_synaptic_plasticity2.02749183
30MP0005000_abnormal_immune_tolerance2.01634629
31MP0009379_abnormal_foot_pigmentation2.00692864
32MP0005360_urolithiasis1.92813695
33MP0009785_altered_susceptibility_to1.91207249
34MP0002452_abnormal_antigen_presenting1.89389896
35MP0004142_abnormal_muscle_tone1.87639894
36MP0009745_abnormal_behavioral_response1.81587093
37MP0001853_heart_inflammation1.81143947
38MP0002277_abnormal_respiratory_mucosa1.78976703
39MP0008004_abnormal_stomach_pH1.77624889
40MP0002723_abnormal_immune_serum1.77594525
41MP0002272_abnormal_nervous_system1.75284072
42MP0005310_abnormal_salivary_gland1.74200349
43MP0001800_abnormal_humoral_immune1.73744652
44MP0003183_abnormal_peptide_metabolism1.72553111
45MP0003011_delayed_dark_adaptation1.69469829
46MP0002420_abnormal_adaptive_immunity1.67139890
47MP0000343_altered_response_to1.63950328
48MP0004510_myositis1.63542722
49MP0001819_abnormal_immune_cell1.62198752
50MP0004883_abnormal_blood_vessel1.61774607
51MP0001968_abnormal_touch/_nociception1.61313045
52MP0001501_abnormal_sleep_pattern1.61106790
53MP0004270_analgesia1.58925257
54MP0010234_abnormal_vibrissa_follicle1.57981327
55MP0002063_abnormal_learning/memory/cond1.57367678
56MP0002736_abnormal_nociception_after1.55459718
57MP0009046_muscle_twitch1.55008328
58MP0008961_abnormal_basal_metabolism1.52695163
59MP0002734_abnormal_mechanical_nocicepti1.46364342
60MP0001845_abnormal_inflammatory_respons1.44367712
61MP0005167_abnormal_blood-brain_barrier1.43675626
62MP0002405_respiratory_system_inflammati1.43295397
63MP0002733_abnormal_thermal_nociception1.43215635
64MP0008260_abnormal_autophagy1.41799576
65MP0002751_abnormal_autonomic_nervous1.40410790
66MP0003075_altered_response_to1.40252677
67MP0003828_pulmonary_edema1.40152250
68MP0005464_abnormal_platelet_physiology1.39053252
69MP0002998_abnormal_bone_remodeling1.39020267
70MP0000685_abnormal_immune_system1.37782223
71MP0001533_abnormal_skeleton_physiology1.36273509
72MP0009333_abnormal_splenocyte_physiolog1.35372118
73MP0002572_abnormal_emotion/affect_behav1.33629150
74MP0005083_abnormal_biliary_tract1.33280282
75MP0004947_skin_inflammation1.33167538
76MP0000751_myopathy1.31759606
77MP0008469_abnormal_protein_level1.31417906
78MP0006035_abnormal_mitochondrial_morpho1.29511757
79MP0003880_abnormal_central_pattern1.28185681
80MP0002090_abnormal_vision1.27616179
81MP0000462_abnormal_digestive_system1.26386644
82MP0001970_abnormal_pain_threshold1.22979866
83MP0003300_gastrointestinal_ulcer1.19893707
84MP0009672_abnormal_birth_weight1.19072441
85MP0002822_catalepsy1.19065919
86MP0002067_abnormal_sensory_capabilities1.17659701
87MP0000465_gastrointestinal_hemorrhage1.13628826
88MP0000716_abnormal_immune_system1.13207542
89MP0005164_abnormal_response_to1.08308874
90MP0003690_abnormal_glial_cell1.06271708
91MP0002132_abnormal_respiratory_system1.05831384
92MP0000747_muscle_weakness1.04847789
93MP0002184_abnormal_innervation1.04706890
94MP0003329_amyloid_beta_deposits1.02393649
95MP0008875_abnormal_xenobiotic_pharmacok1.02238789
96MP0000689_abnormal_spleen_morphology1.01618170
97MP0009840_abnormal_foam_cell1.01189766
98MP0009278_abnormal_bone_marrow0.99951539
99MP0002722_abnormal_immune_system0.98038437
100MP0002876_abnormal_thyroid_physiology0.96920449
101MP0000647_abnormal_sebaceous_gland0.96919296
102MP0009764_decreased_sensitivity_to0.96619669
103MP0005365_abnormal_bile_salt0.95680015
104MP0003632_abnormal_nervous_system0.94997211
105MP0005670_abnormal_white_adipose0.92015362
106MP0010386_abnormal_urinary_bladder0.91883985
107MP0002429_abnormal_blood_cell0.91384080
108MP0002398_abnormal_bone_marrow0.90867422
109* MP0002066_abnormal_motor_capabilities/c0.90548347
110MP0002882_abnormal_neuron_morphology0.88057681
111MP0001486_abnormal_startle_reflex0.87905412
112MP0003091_abnormal_cell_migration0.87007664
113MP0005397_hematopoietic_system_phenotyp0.86685294
114MP0001545_abnormal_hematopoietic_system0.86685294
115MP0003656_abnormal_erythrocyte_physiolo0.84547082
116MP0005386_behavior/neurological_phenoty0.82842852
117MP0004924_abnormal_behavior0.82842852
118* MP0005448_abnormal_energy_balance0.82272621
119MP0004272_abnormal_basement_membrane0.82088894
120MP0002095_abnormal_skin_pigmentation0.81806254
121MP0004130_abnormal_muscle_cell0.81613026
122MP0002229_neurodegeneration0.81026991
123MP0005085_abnormal_gallbladder_physiolo0.80517573
124MP0003279_aneurysm0.80024935
125MP0001984_abnormal_olfaction0.77353568
126MP0005166_decreased_susceptibility_to0.75221901
127MP0004019_abnormal_vitamin_homeostasis0.74588380
128MP0002152_abnormal_brain_morphology0.74449021
129MP0000249_abnormal_blood_vessel0.74327698
130MP0006054_spinal_hemorrhage0.73340265
131* MP0002069_abnormal_eating/drinking_beha0.73166990
132MP0000015_abnormal_ear_pigmentation0.72802283
133MP0000778_abnormal_nervous_system0.72633756
134MP0004742_abnormal_vestibular_system0.72422063
135MP0005058_abnormal_lysosome_morphology0.71924732
136MP0003938_abnormal_ear_development0.71402578
137MP0000609_abnormal_liver_physiology0.70621625
138MP0004808_abnormal_hematopoietic_stem0.69385037
139MP0002332_abnormal_exercise_endurance0.69159030
140MP0005451_abnormal_body_composition0.67659777
141MP0005319_abnormal_enzyme/_coenzyme0.66737606
142MP0004133_heterotaxia0.64759261
143MP0006292_abnormal_olfactory_placode0.63326195
144MP0003763_abnormal_thymus_physiology0.62996510
145MP0002933_joint_inflammation0.62285911
146MP0009763_increased_sensitivity_to0.62275309
147MP0003879_abnormal_hair_cell0.61241913
148MP0001324_abnormal_eye_pigmentation0.60114907
149MP0002557_abnormal_social/conspecific_i0.59548884
150MP0000371_diluted_coat_color0.59358786
151MP0000920_abnormal_myelination0.58291676
152MP0000358_abnormal_cell_content/0.58112039
153MP0001756_abnormal_urination0.57324085
154MP0005551_abnormal_eye_electrophysiolog0.56259844
155MP0003631_nervous_system_phenotype0.55558628
156MP0005076_abnormal_cell_differentiation0.54594510
157MP0002877_abnormal_melanocyte_morpholog0.53648234
158MP0010329_abnormal_lipoprotein_level0.53295743
159MP0008874_decreased_physiological_sensi0.53045714
160MP0004885_abnormal_endolymph0.52919971
161MP0004197_abnormal_fetal_growth/weight/0.52444150
162MP0002752_abnormal_somatic_nervous0.51322467
163MP0005408_hypopigmentation0.50917917
164* MP0005535_abnormal_body_temperature0.50776564
165MP0002098_abnormal_vibrissa_morphology0.50722153
166MP0002971_abnormal_brown_adipose0.50717375
167* MP0002118_abnormal_lipid_homeostasis0.49999526
168MP0002078_abnormal_glucose_homeostasis0.49859623
169MP0001664_abnormal_digestion0.49638297
170MP0005409_darkened_coat_color0.49609966
171MP0004381_abnormal_hair_follicle0.49305603
172MP0003866_abnormal_defecation0.48624342
173MP0000639_abnormal_adrenal_gland0.48399474
174MP0002139_abnormal_hepatobiliary_system0.47172350
175MP0003634_abnormal_glial_cell0.46689150
176MP0010678_abnormal_skin_adnexa0.45629050
177MP0004233_abnormal_muscle_weight0.45308129
178MP0008872_abnormal_physiological_respon0.44679025
179MP0004811_abnormal_neuron_physiology0.44201158
180MP0009643_abnormal_urine_homeostasis0.43575928
181MP0001727_abnormal_embryo_implantation0.43470711
182MP0002909_abnormal_adrenal_gland0.42473261
183MP0009703_decreased_birth_body0.42158793
184MP0001502_abnormal_circadian_rhythm0.42055406

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)7.86713901
2Abnormality of glycosphingolipid metabolism (HP:0004343)7.86713901
3Abnormality of glycolipid metabolism (HP:0010969)7.86713901
4Abnormal hair whorl (HP:0010721)6.82938604
5Polyphagia (HP:0002591)6.48418921
6Abnormality of the labia minora (HP:0012880)6.45005314
7Dry hair (HP:0011359)6.02115478
8Focal motor seizures (HP:0011153)5.71803653
9Oligomenorrhea (HP:0000876)5.52237977
10Increased cerebral lipofuscin (HP:0011813)5.43607573
11Eczematoid dermatitis (HP:0000976)5.24429057
12Abnormality of macrophages (HP:0004311)5.12824035
13Failure to thrive in infancy (HP:0001531)4.98019182
14Recurrent abscess formation (HP:0002722)4.65527189
15Progressive external ophthalmoplegia (HP:0000590)4.54636439
16Recurrent bacterial skin infections (HP:0005406)4.49214640
17Recurrent gram-negative bacterial infections (HP:0005420)4.47655838
18Cortical visual impairment (HP:0100704)4.39989265
19Loss of speech (HP:0002371)4.38681058
20Atonic seizures (HP:0010819)4.36458558
21Progressive muscle weakness (HP:0003323)4.35502469
22Vacuolated lymphocytes (HP:0001922)4.29956943
23Hyperlipoproteinemia (HP:0010980)4.28915705
24Abnormal eating behavior (HP:0100738)4.22364229
25Upper motor neuron abnormality (HP:0002127)4.12004273
26Increased neuronal autofluorescent lipopigment (HP:0002074)4.11725627
27Renal salt wasting (HP:0000127)4.10703043
28Poor suck (HP:0002033)4.08465648
29Disinhibition (HP:0000734)4.08357035
30Myokymia (HP:0002411)3.96022129
31Double outlet right ventricle (HP:0001719)3.90224653
32Congenital malformation of the right heart (HP:0011723)3.90224653
33Cerebral inclusion bodies (HP:0100314)3.86336208
34Autoimmune thrombocytopenia (HP:0001973)3.79837644
35Hypotrichosis (HP:0001006)3.77986610
36Hip dysplasia (HP:0001385)3.75262036
37Dynein arm defect of respiratory motile cilia (HP:0012255)3.58859325
38Absent/shortened dynein arms (HP:0200106)3.58859325
39Absence seizures (HP:0002121)3.56383953
40Hemiparesis (HP:0001269)3.52620709
41Systemic lupus erythematosus (HP:0002725)3.51409356
42Mediastinal lymphadenopathy (HP:0100721)3.45419329
43Dysostosis multiplex (HP:0000943)3.44804849
44Hypoventilation (HP:0002791)3.41270596
45Dialeptic seizures (HP:0011146)3.40550505
46Generalized hypotonia (HP:0001290)3.38280051
47Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.36909054
48Glucose intolerance (HP:0000833)3.25623105
49Apathy (HP:0000741)3.23419359
50Focal seizures (HP:0007359)3.20959786
51Woolly hair (HP:0002224)3.19278398
52Hemiplegia (HP:0002301)3.18930116
53Diminished motivation (HP:0000745)3.18488251
54Anomalous pulmonary venous return (HP:0010772)3.17783623
55Supernumerary spleens (HP:0009799)3.17589189
56Anteriorly placed anus (HP:0001545)3.09427973
57Narrow nasal bridge (HP:0000446)3.03978279
58Abnormality of polysaccharide metabolism (HP:0011012)3.02273341
59Abnormality of glycosaminoglycan metabolism (HP:0004371)3.02273341
60Abnormality of mucopolysaccharide metabolism (HP:0011020)3.02273341
61Sleep apnea (HP:0010535)3.01673706
62Mutism (HP:0002300)2.98479231
63Mucopolysacchariduria (HP:0008155)2.98427825
64Urinary glycosaminoglycan excretion (HP:0003541)2.98427825
65Neuronal loss in central nervous system (HP:0002529)2.94793195
66Recurrent fungal infections (HP:0002841)2.91837834
67Status epilepticus (HP:0002133)2.87622996
68Abnormal ciliary motility (HP:0012262)2.82156382
69Personality changes (HP:0000751)2.75713446
70Labial hypoplasia (HP:0000066)2.75617751
71Febrile seizures (HP:0002373)2.74391001
72Cellulitis (HP:0100658)2.73404889
73Abnormality of the pulmonary veins (HP:0011718)2.72780058
74T lymphocytopenia (HP:0005403)2.70950543
75Gingivitis (HP:0000230)2.69960119
76External ophthalmoplegia (HP:0000544)2.69029411
77Abnormality of pain sensation (HP:0010832)2.68471275
78Impaired pain sensation (HP:0007328)2.68471275
79Recurrent skin infections (HP:0001581)2.68079577
80Inappropriate behavior (HP:0000719)2.67828939
81Insidious onset (HP:0003587)2.66681618
82Termporal pattern (HP:0011008)2.66681618
83Chronic obstructive pulmonary disease (HP:0006510)2.63330322
84Obstructive lung disease (HP:0006536)2.63330322
85Keratoconjunctivitis sicca (HP:0001097)2.62075134
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.61776166
87Generalized hypopigmentation (HP:0007513)2.61743484
88Axonal loss (HP:0003447)2.60912129
89Abnormality of the clitoris (HP:0000056)2.60173498
90Interstitial pulmonary disease (HP:0006530)2.58252312
91Abnormal sex determination (HP:0012244)2.57353394
92Sex reversal (HP:0012245)2.57353394
93Generalized tonic-clonic seizures (HP:0002069)2.57293614
94Colitis (HP:0002583)2.56890008
95Recurrent viral infections (HP:0004429)2.54764279
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.54270862
97Degeneration of the lateral corticospinal tracts (HP:0002314)2.54270862
98Myocardial infarction (HP:0001658)2.52969725
99Action tremor (HP:0002345)2.51934026
100Abnormal respiratory motile cilium physiology (HP:0012261)2.50225697
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49626440
102Hypoplastic female external genitalia (HP:0012815)2.46355937
103Abnormality of the lower motor neuron (HP:0002366)2.44065127
104Esotropia (HP:0000565)2.43251487
105Visual hallucinations (HP:0002367)2.42178525
106Hepatosplenomegaly (HP:0001433)2.41706708
107Abnormality of the motor neurons (HP:0002450)2.40230767
108Abnormal neuron morphology (HP:0012757)2.40230767
109Purpura (HP:0000979)2.38764835
110Myositis (HP:0100614)2.31103173
111Iris hypopigmentation (HP:0007730)2.30794070
112Abnormality of T cell number (HP:0011839)2.29092798
113Abnormality of the labia (HP:0000058)2.27586259
114Keratoconjunctivitis (HP:0001096)2.27452703
115Abnormality of the periventricular white matter (HP:0002518)2.27440350
116Xanthomatosis (HP:0000991)2.26777705
117Abnormality of the corticospinal tract (HP:0002492)2.24483455
118Abnormality of the lumbar spine (HP:0100712)2.24343895
119Hypoplastic nipples (HP:0002557)2.24120463
120Epileptic encephalopathy (HP:0200134)2.22714097
121Multiple enchondromatosis (HP:0005701)2.21922900
122Chronic mucocutaneous candidiasis (HP:0002728)2.19438552
123Recurrent cutaneous fungal infections (HP:0011370)2.19438552
124Abnormal respiratory epithelium morphology (HP:0012253)2.17852393
125Abnormal respiratory motile cilium morphology (HP:0005938)2.17852393
126Prolonged neonatal jaundice (HP:0006579)2.17400102
127Breast hypoplasia (HP:0003187)2.16837709
128Truncus arteriosus (HP:0001660)2.16114005
129Abnormality of the vasculature of the conjunctiva (HP:0008054)2.15534045
130Facial hemangioma (HP:0000329)2.13253002
131Progressive neurologic deterioration (HP:0002344)2.13108734
132Hyperaldosteronism (HP:0000859)2.10630472
133Abnormal pupillary function (HP:0007686)2.10345407
134Abnormality of hair growth rate (HP:0011363)2.10097672
135Slow-growing hair (HP:0002217)2.10097672
136Meningitis (HP:0001287)2.09602412
137Dementia (HP:0000726)2.07678241
138Unsteady gait (HP:0002317)2.06968886
139Scanning speech (HP:0002168)2.06570042
140Decreased muscle mass (HP:0003199)2.06161731
141Glomerulonephritis (HP:0000099)2.05042348
142Optic neuritis (HP:0100653)2.04688966
143Retrobulbar optic neuritis (HP:0100654)2.04688966
144Hyperventilation (HP:0002883)2.03989162
145Pathologic fracture (HP:0002756)2.03868134
146Hypercortisolism (HP:0001578)2.03115867
147Generalized myoclonic seizures (HP:0002123)2.03042468
148Neurofibrillary tangles (HP:0002185)2.00527831
149Urticaria (HP:0001025)2.00224959
150Septate vagina (HP:0001153)1.99548285
151Epidermoid cyst (HP:0200040)1.98928148
152Abnormality of aromatic amino acid family metabolism (HP:0004338)1.98908892
153Stomatitis (HP:0010280)1.98410209
154Retinal atrophy (HP:0001105)1.97627058
155Neoplasm of the heart (HP:0100544)1.97099938
156Asplenia (HP:0001746)1.96759683
157Orchitis (HP:0100796)1.95098165
158Global brain atrophy (HP:0002283)1.94850041
159Recurrent sinusitis (HP:0011108)1.90999706
160Osteomyelitis (HP:0002754)1.90782085
161Abnormality of the pupil (HP:0000615)1.90636951
162Asymmetric septal hypertrophy (HP:0001670)1.90410150
163Agnosia (HP:0010524)1.90396634
164Abnormal glucose tolerance (HP:0001952)1.90295255
165Peripheral demyelination (HP:0011096)1.89242174
166Increased serum ferritin (HP:0003281)1.88440598
167Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88139761
168Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87307536
169Bone pain (HP:0002653)1.86689818
170Chronic bronchitis (HP:0004469)1.85492237
171Impaired vibration sensation in the lower limbs (HP:0002166)1.84455690
172Cerebral aneurysm (HP:0004944)1.84035626
173Inflammation of the large intestine (HP:0002037)1.83928702
174Pseudobulbar signs (HP:0002200)1.82729838
175Redundant skin (HP:0001582)1.79208918
176Dysdiadochokinesis (HP:0002075)1.76879796
177Thoracolumbar scoliosis (HP:0002944)1.75373632
178Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74857715
179Gastrointestinal inflammation (HP:0004386)1.74314647
180Skin nodule (HP:0200036)1.71924268
181Growth hormone deficiency (HP:0000824)1.71648982
182Fetal akinesia sequence (HP:0001989)1.71207868
183Aplasia/Hypoplasia of the spleen (HP:0010451)1.70852463
184Increased CSF protein (HP:0002922)1.70498437
185Hypokalemic alkalosis (HP:0001949)1.70401398
186Complement deficiency (HP:0004431)1.69726698
187Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.69218667
188Restrictive lung disease (HP:0002091)1.69198826
189Increased IgM level (HP:0003496)1.67948988
190Rhinitis (HP:0012384)1.67231882
191Aplastic anemia (HP:0001915)1.66995037
192Supranuclear gaze palsy (HP:0000605)1.66875451
193Psychosis (HP:0000709)1.66856722
194Nasal polyposis (HP:0100582)1.66313871
195Hypoalphalipoproteinemia (HP:0003233)1.66008630
196Nuclear cataract (HP:0100018)1.65038193
197Pulmonary infiltrates (HP:0002113)1.64632761
198Metaphyseal irregularity (HP:0003025)1.64124558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF5.04363615
2RIPK44.10644511
3TNIK3.99595924
4PRKD33.97837604
5BLK3.71004828
6EPHA23.21519592
7MAP3K93.13488854
8NTRK33.05539728
9MST1R3.02787662
10TAOK12.85824310
11STK162.58256160
12BCKDK2.53061743
13TESK22.48840937
14PIK3CG2.37617469
15NME22.37057888
16KSR22.25776145
17TRPM72.25511502
18IRAK22.17702767
19PDK22.12003153
20NEK62.05608975
21BMPR22.02007441
22PRPF4B2.00334687
23MAP3K131.99427598
24EPHB11.96120666
25MAP4K11.90588221
26ACVR1B1.89155466
27NTRK21.88555132
28MAP3K111.87632297
29ZAP701.86680744
30MAP3K141.79300655
31CSK1.76966844
32MAPK131.75993679
33TYK21.70691405
34EEF2K1.69810195
35PAK61.64967452
36GRK71.60325106
37AKT31.58440501
38FGR1.58172275
39BRAF1.51877001
40BTK1.49560870
41MAP2K31.49210003
42LYN1.43076207
43EPHA31.42105484
44TBK11.41430014
45CSNK1G11.38751476
46JAK11.38544541
47HCK1.28594863
48PRKCI1.25550689
49IRAK31.24533795
50BUB11.22009710
51TGFBR21.21518123
52TAOK31.20607463
53JAK21.19515599
54TLK11.18680277
55ERN11.17374783
56PDGFRA1.16895545
57LRRK21.15936019
58IRAK41.14312758
59MARK21.12378739
60MAP3K11.11955386
61CSF1R1.11347225
62TAOK21.06871944
63KIT1.06755538
64BRD41.06162304
65CSNK1G31.03369789
66CAMK1D1.01523584
67UHMK11.00015754
68BMPR1B0.99605288
69EPHA40.98383499
70MARK10.97752392
71IKBKB0.96718105
72YES10.96271581
73IKBKE0.96108130
74MAP3K30.91848458
75PDPK10.91825011
76MINK10.91271310
77CASK0.90050718
78PNCK0.88220177
79FGFR40.87726578
80ITK0.87248817
81STK110.85036747
82ICK0.84040176
83MAP3K20.82546579
84TSSK60.81942915
85ABL20.81545112
86FES0.81121188
87JAK30.81033518
88LCK0.79754562
89MAPK110.79617365
90NLK0.78444185
91MARK30.77843613
92CDK50.74951480
93GRK60.74822009
94PAK30.73589363
95CSNK1A1L0.72344946
96NME10.71750676
97MATK0.71443233
98MAP3K50.70538118
99PIM10.68271898
100PDK10.68022578
101PHKG10.67902662
102PHKG20.67902662
103MAP4K20.67571161
104CDK60.67467176
105CHUK0.66148577
106MAP2K40.65882828
107MAP3K40.64757553
108CSNK1G20.64721238
109MET0.64628709
110LIMK10.64498707
111PRKCE0.63718089
112PKN10.63707707
113MAPK150.63652975
114CDC42BPA0.63556019
115FYN0.63540138
116LMTK20.63455143
117DAPK20.63384032
118CDK140.60486765
119CDK150.60342211
120MAP3K120.58910043
121SGK10.58540970
122SIK10.58250868
123PRKCG0.58058188
124CAMKK20.57802190
125MAPK70.55885509
126MAP2K20.55701245
127PIM20.55252758
128DYRK1B0.55048989
129PRKCH0.54653855
130CDK180.53552628
131MOS0.53464871
132NTRK10.52704822
133ABL10.52260074
134RAF10.50154899
135ADRBK10.49285549
136CDK11A0.49274173
137TXK0.49180914
138DDR20.48045851
139RPS6KL10.48024001
140RPS6KC10.48024001
141TRIB30.47881671
142ALK0.47363964
143CAMK1G0.46797204
144DAPK30.46708200
145WNK40.46161728
146NEK90.45839021
147KSR10.45701674
148PDGFRB0.44156039
149SYK0.43413297
150DYRK20.43231752
151RIPK10.42230474
152AKT20.40434618
153PRKD20.40266807
154TNK20.39373875
155CSNK1E0.36855486
156HIPK20.34910450
157PLK20.34283026
158RET0.33653669
159ERBB20.33383678
160ROCK20.32259357
161SGK4940.32103724
162SGK2230.32103724
163MAPK90.31735639
164BCR0.29433618
165CSNK1A10.29120374
166TESK10.28165666
167RPS6KA20.26176832
168FER0.25829191
169MAP2K10.25520314
170PKN20.25183076
171MAPK120.25162989

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.25444261
2Staphylococcus aureus infection_Homo sapiens_hsa051503.25884218
3Nicotine addiction_Homo sapiens_hsa050333.16895029
4Synaptic vesicle cycle_Homo sapiens_hsa047212.92327267
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.89648501
6Ribosome_Homo sapiens_hsa030102.87757817
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.76353665
8Osteoclast differentiation_Homo sapiens_hsa043802.53960672
9Leishmaniasis_Homo sapiens_hsa051402.48735005
10GABAergic synapse_Homo sapiens_hsa047272.48704703
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.46945036
12Taste transduction_Homo sapiens_hsa047422.46536743
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33562247
14Collecting duct acid secretion_Homo sapiens_hsa049662.29447556
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.24746638
16Prion diseases_Homo sapiens_hsa050202.18370678
17Tuberculosis_Homo sapiens_hsa051522.18153994
18Asthma_Homo sapiens_hsa053102.05091919
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04640267
20Vibrio cholerae infection_Homo sapiens_hsa051102.02188844
21Morphine addiction_Homo sapiens_hsa050321.96848031
22Vitamin B6 metabolism_Homo sapiens_hsa007501.96416177
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91054578
24Dopaminergic synapse_Homo sapiens_hsa047281.76651380
25Steroid biosynthesis_Homo sapiens_hsa001001.73077451
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69173593
27B cell receptor signaling pathway_Homo sapiens_hsa046621.68809811
28Antigen processing and presentation_Homo sapiens_hsa046121.68667502
29Salivary secretion_Homo sapiens_hsa049701.68614122
30Allograft rejection_Homo sapiens_hsa053301.65432521
31Long-term potentiation_Homo sapiens_hsa047201.65172645
32Legionellosis_Homo sapiens_hsa051341.58917631
33Graft-versus-host disease_Homo sapiens_hsa053321.56663109
34Hematopoietic cell lineage_Homo sapiens_hsa046401.52218653
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48844513
36Circadian entrainment_Homo sapiens_hsa047131.47100227
37Systemic lupus erythematosus_Homo sapiens_hsa053221.45759409
38Cocaine addiction_Homo sapiens_hsa050301.45476982
39Amphetamine addiction_Homo sapiens_hsa050311.44956724
40Autoimmune thyroid disease_Homo sapiens_hsa053201.44509176
41Toxoplasmosis_Homo sapiens_hsa051451.44417042
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43546865
43Malaria_Homo sapiens_hsa051441.42815455
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.40409340
45Pertussis_Homo sapiens_hsa051331.40403315
46Gastric acid secretion_Homo sapiens_hsa049711.39682452
47Insulin secretion_Homo sapiens_hsa049111.38022998
48Glutamatergic synapse_Homo sapiens_hsa047241.36420645
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.35904877
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.35608917
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34365565
52Carbohydrate digestion and absorption_Homo sapiens_hsa049731.33597213
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30135723
54Long-term depression_Homo sapiens_hsa047301.29166912
55Bile secretion_Homo sapiens_hsa049761.27224965
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23224196
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22197920
58Oxidative phosphorylation_Homo sapiens_hsa001901.17231423
59Salmonella infection_Homo sapiens_hsa051321.15228416
60Fatty acid elongation_Homo sapiens_hsa000621.15194266
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15104595
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12890037
63Primary bile acid biosynthesis_Homo sapiens_hsa001201.12467360
64Sphingolipid metabolism_Homo sapiens_hsa006001.08808922
65Viral myocarditis_Homo sapiens_hsa054161.08253161
66Cholinergic synapse_Homo sapiens_hsa047251.06767090
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04198339
68Galactose metabolism_Homo sapiens_hsa000521.04126195
69Type II diabetes mellitus_Homo sapiens_hsa049301.01238741
70Butanoate metabolism_Homo sapiens_hsa006501.00746072
71Dilated cardiomyopathy_Homo sapiens_hsa054140.99761599
72Parkinsons disease_Homo sapiens_hsa050120.99200459
73Type I diabetes mellitus_Homo sapiens_hsa049400.98937417
74Complement and coagulation cascades_Homo sapiens_hsa046100.98466360
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96566499
76Nitrogen metabolism_Homo sapiens_hsa009100.96352839
77Gap junction_Homo sapiens_hsa045400.94498817
78Lysosome_Homo sapiens_hsa041420.94348470
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93143921
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89681970
81Oxytocin signaling pathway_Homo sapiens_hsa049210.88996090
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88844794
83GnRH signaling pathway_Homo sapiens_hsa049120.88127187
84Influenza A_Homo sapiens_hsa051640.87621973
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87484687
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87133569
87TNF signaling pathway_Homo sapiens_hsa046680.86460330
88Cardiac muscle contraction_Homo sapiens_hsa042600.85708078
89Olfactory transduction_Homo sapiens_hsa047400.85502614
90Starch and sucrose metabolism_Homo sapiens_hsa005000.85336231
91Renin secretion_Homo sapiens_hsa049240.85148939
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84435762
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84408356
94Serotonergic synapse_Homo sapiens_hsa047260.84301717
95Primary immunodeficiency_Homo sapiens_hsa053400.84276971
96Rheumatoid arthritis_Homo sapiens_hsa053230.84026187
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83501993
98Estrogen signaling pathway_Homo sapiens_hsa049150.83343398
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82386030
100Chemokine signaling pathway_Homo sapiens_hsa040620.80995761
101Alzheimers disease_Homo sapiens_hsa050100.80887419
102Glucagon signaling pathway_Homo sapiens_hsa049220.79968235
103Non-small cell lung cancer_Homo sapiens_hsa052230.79203139
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77924151
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.77006629
106Melanogenesis_Homo sapiens_hsa049160.76499168
107Renin-angiotensin system_Homo sapiens_hsa046140.75478323
108Acute myeloid leukemia_Homo sapiens_hsa052210.75349392
109Apoptosis_Homo sapiens_hsa042100.72995021
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71952617
111Axon guidance_Homo sapiens_hsa043600.71862474
112AMPK signaling pathway_Homo sapiens_hsa041520.71506918
113Measles_Homo sapiens_hsa051620.70612899
114Hepatitis B_Homo sapiens_hsa051610.70052827
115Proteasome_Homo sapiens_hsa030500.69744983
116Pentose phosphate pathway_Homo sapiens_hsa000300.69298921
117* Adipocytokine signaling pathway_Homo sapiens_hsa049200.68875098
118Insulin signaling pathway_Homo sapiens_hsa049100.68489664
119Dorso-ventral axis formation_Homo sapiens_hsa043200.68371636
120Mineral absorption_Homo sapiens_hsa049780.67760670
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.65623571
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.64990408
123Thyroid hormone synthesis_Homo sapiens_hsa049180.63590084
124Pancreatic cancer_Homo sapiens_hsa052120.63267978
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61708389
126Glycerolipid metabolism_Homo sapiens_hsa005610.61360331
127Propanoate metabolism_Homo sapiens_hsa006400.58569310
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58187986
129Shigellosis_Homo sapiens_hsa051310.56798554
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56341337
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.56041009
132Calcium signaling pathway_Homo sapiens_hsa040200.55607407
133Fatty acid metabolism_Homo sapiens_hsa012120.55237575
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54756465
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54047980
136Notch signaling pathway_Homo sapiens_hsa043300.53759419
137Sulfur metabolism_Homo sapiens_hsa009200.53408029
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53132275
139Prolactin signaling pathway_Homo sapiens_hsa049170.53022278
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.52597806
141Oocyte meiosis_Homo sapiens_hsa041140.51863474
142Ovarian steroidogenesis_Homo sapiens_hsa049130.51304581
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51209016
144T cell receptor signaling pathway_Homo sapiens_hsa046600.50855760
145Fructose and mannose metabolism_Homo sapiens_hsa000510.50561181
146VEGF signaling pathway_Homo sapiens_hsa043700.49840940
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.49111859
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.48675598
149Renal cell carcinoma_Homo sapiens_hsa052110.48658851
150Herpes simplex infection_Homo sapiens_hsa051680.48466333
151Huntingtons disease_Homo sapiens_hsa050160.46719275
152Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46694115
153Hepatitis C_Homo sapiens_hsa051600.46237735
154Phagosome_Homo sapiens_hsa041450.45638758
155Inositol phosphate metabolism_Homo sapiens_hsa005620.45377795
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.44898480
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44057828
158Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43477200
159cAMP signaling pathway_Homo sapiens_hsa040240.43460815
160PPAR signaling pathway_Homo sapiens_hsa033200.43185524
161ABC transporters_Homo sapiens_hsa020100.42103161
162Phenylalanine metabolism_Homo sapiens_hsa003600.37787703
163Viral carcinogenesis_Homo sapiens_hsa052030.37354098
164Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37194742
165Ether lipid metabolism_Homo sapiens_hsa005650.37190258
166Pancreatic secretion_Homo sapiens_hsa049720.36997590
167Arginine and proline metabolism_Homo sapiens_hsa003300.36359997
168Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35692128
169Arginine biosynthesis_Homo sapiens_hsa002200.35216890
170Endocytosis_Homo sapiens_hsa041440.34979855
171African trypanosomiasis_Homo sapiens_hsa051430.34209187
172Platelet activation_Homo sapiens_hsa046110.31277454
173HIF-1 signaling pathway_Homo sapiens_hsa040660.30735940
174Chronic myeloid leukemia_Homo sapiens_hsa052200.30387256
175Fatty acid biosynthesis_Homo sapiens_hsa000610.29726196
176Alcoholism_Homo sapiens_hsa050340.28817405
177mTOR signaling pathway_Homo sapiens_hsa041500.25549906
178Bladder cancer_Homo sapiens_hsa052190.24678781
179Amoebiasis_Homo sapiens_hsa051460.24327608

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