AGT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.24278776
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.24278776
3L-phenylalanine metabolic process (GO:0006558)6.90625829
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.90625829
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.51801145
6aromatic amino acid family catabolic process (GO:0009074)6.40303808
7regulation of plasminogen activation (GO:0010755)5.87822880
8high-density lipoprotein particle remodeling (GO:0034375)5.68226995
9intestinal cholesterol absorption (GO:0030299)5.67821899
10indole-containing compound catabolic process (GO:0042436)5.65853110
11indolalkylamine catabolic process (GO:0046218)5.65853110
12tryptophan catabolic process (GO:0006569)5.65853110
13glyoxylate metabolic process (GO:0046487)5.60634198
14bile acid biosynthetic process (GO:0006699)5.57925236
15alpha-linolenic acid metabolic process (GO:0036109)5.57686434
16kynurenine metabolic process (GO:0070189)5.55876615
17negative regulation of fibrinolysis (GO:0051918)5.44086835
18regulation of apoptotic cell clearance (GO:2000425)5.41923796
19urea metabolic process (GO:0019627)5.36302534
20urea cycle (GO:0000050)5.36302534
21tryptophan metabolic process (GO:0006568)5.34239782
22sulfur amino acid catabolic process (GO:0000098)5.25982551
23regulation of fibrinolysis (GO:0051917)5.23871377
24cysteine metabolic process (GO:0006534)5.22498199
25reverse cholesterol transport (GO:0043691)5.12980320
26complement activation, alternative pathway (GO:0006957)5.12403351
27peptidyl-glutamic acid carboxylation (GO:0017187)5.10370042
28protein carboxylation (GO:0018214)5.10370042
29regulation of protein activation cascade (GO:2000257)5.06515792
30* macromolecular complex remodeling (GO:0034367)4.95726277
31* plasma lipoprotein particle remodeling (GO:0034369)4.95726277
32* protein-lipid complex remodeling (GO:0034368)4.95726277
33serine family amino acid catabolic process (GO:0009071)4.95462615
34negative regulation of protein activation cascade (GO:2000258)4.94890535
35nitrogen cycle metabolic process (GO:0071941)4.92425368
36regulation of triglyceride catabolic process (GO:0010896)4.92103409
37* regulation of cholesterol esterification (GO:0010872)4.81527807
38bile acid metabolic process (GO:0008206)4.78431895
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.72879792
40phospholipid efflux (GO:0033700)4.71272861
41regulation of complement activation (GO:0030449)4.71239209
42homocysteine metabolic process (GO:0050667)4.67186287
43amino-acid betaine metabolic process (GO:0006577)4.65808892
44aromatic amino acid family metabolic process (GO:0009072)4.64048509
45tyrosine metabolic process (GO:0006570)4.63210527
46lysine metabolic process (GO:0006553)4.56229370
47lysine catabolic process (GO:0006554)4.56229370
48alpha-amino acid catabolic process (GO:1901606)4.53143682
49acute-phase response (GO:0006953)4.52462044
50triglyceride homeostasis (GO:0070328)4.50908077
51acylglycerol homeostasis (GO:0055090)4.50908077
52plasma lipoprotein particle clearance (GO:0034381)4.49451474
53negative regulation of sterol transport (GO:0032372)4.49059398
54negative regulation of cholesterol transport (GO:0032375)4.49059398
55regulation of humoral immune response (GO:0002920)4.45154753
56negative regulation of hemostasis (GO:1900047)4.43844812
57negative regulation of blood coagulation (GO:0030195)4.43844812
58glutamate metabolic process (GO:0006536)4.39689468
59epoxygenase P450 pathway (GO:0019373)4.37001090
60dicarboxylic acid biosynthetic process (GO:0043650)4.32532473
61cellular ketone body metabolic process (GO:0046950)4.30855391
62plasma lipoprotein particle assembly (GO:0034377)4.30307758
63cholesterol efflux (GO:0033344)4.26960438
64* low-density lipoprotein particle remodeling (GO:0034374)4.22485965
65positive regulation of hemostasis (GO:1900048)4.22481564
66positive regulation of blood coagulation (GO:0030194)4.22481564
67proline metabolic process (GO:0006560)4.22204982
68positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.21120974
69cellular amino acid catabolic process (GO:0009063)4.20465733
70amine catabolic process (GO:0009310)4.09970280
71cellular biogenic amine catabolic process (GO:0042402)4.09970280
72regulation of cholesterol biosynthetic process (GO:0045540)4.08560697
73cellular modified amino acid catabolic process (GO:0042219)4.06313655
74negative regulation of coagulation (GO:0050819)4.06271397
75coenzyme catabolic process (GO:0009109)4.05366136
76very-low-density lipoprotein particle assembly (GO:0034379)4.02847644
77indolalkylamine metabolic process (GO:0006586)4.02502860
78negative regulation of complement activation (GO:0045916)4.02103417
79bile acid and bile salt transport (GO:0015721)4.00753879
80glycine metabolic process (GO:0006544)3.99766549
81imidazole-containing compound metabolic process (GO:0052803)3.99190763
82negative regulation of wound healing (GO:0061045)3.93874506
83serine family amino acid metabolic process (GO:0009069)3.91561875
84positive regulation of coagulation (GO:0050820)3.86468559
85cellular glucuronidation (GO:0052695)3.86377240
86fibrinolysis (GO:0042730)3.86094690
87arginine metabolic process (GO:0006525)3.85830008
88* plasma lipoprotein particle organization (GO:0071827)3.85523968
89protein-lipid complex assembly (GO:0065005)3.84174202
90benzene-containing compound metabolic process (GO:0042537)3.80847497
91cholesterol transport (GO:0030301)3.80232284
92sterol transport (GO:0015918)3.80232284
93ethanol oxidation (GO:0006069)3.78149986
94negative regulation of lipase activity (GO:0060192)3.75791627
95positive regulation of lipid catabolic process (GO:0050996)3.75424550
96short-chain fatty acid metabolic process (GO:0046459)3.75102246
97serine family amino acid biosynthetic process (GO:0009070)3.74611790
98phospholipid homeostasis (GO:0055091)3.74520612
99ketone body metabolic process (GO:1902224)3.72773350
100carboxylic acid catabolic process (GO:0046395)3.68396441
101organic acid catabolic process (GO:0016054)3.68396441
102drug catabolic process (GO:0042737)3.68296449
103blood coagulation, intrinsic pathway (GO:0007597)3.67653047
104positive regulation of triglyceride lipase activity (GO:0061365)3.66566989
105positive regulation of lipoprotein lipase activity (GO:0051006)3.66566989
106exogenous drug catabolic process (GO:0042738)3.64786343
107cholesterol homeostasis (GO:0042632)3.64373069
108* protein-lipid complex subunit organization (GO:0071825)3.60829420
109aldehyde catabolic process (GO:0046185)3.60419286
110sterol homeostasis (GO:0055092)3.58923737
111protein activation cascade (GO:0072376)3.58198724
112complement activation (GO:0006956)3.56178770
113intestinal absorption (GO:0050892)3.56115432
114aspartate family amino acid catabolic process (GO:0009068)3.55647180
115carnitine metabolic process (GO:0009437)3.55429709
116complement activation, classical pathway (GO:0006958)3.55366136
117lipoprotein metabolic process (GO:0042157)3.52884603
118positive regulation of fatty acid beta-oxidation (GO:0032000)3.52452489
119regulation of cholesterol homeostasis (GO:2000188)3.52264747
120omega-hydroxylase P450 pathway (GO:0097267)3.52143265
121cofactor catabolic process (GO:0051187)3.50887372
122acetyl-CoA metabolic process (GO:0006084)3.47864343
123regulation of bile acid biosynthetic process (GO:0070857)3.44883801
124regulation of cholesterol metabolic process (GO:0090181)3.40273356
125cytolysis (GO:0019835)3.40232568
126acute inflammatory response (GO:0002526)3.36424340
127diacylglycerol metabolic process (GO:0046339)3.35971835
128glucuronate metabolic process (GO:0019585)3.34664940
129uronic acid metabolic process (GO:0006063)3.34664940
130lipid homeostasis (GO:0055088)3.27587935
131ethanol metabolic process (GO:0006067)3.26807720
132response to mercury ion (GO:0046689)3.23508533
133negative regulation of lipid transport (GO:0032369)3.22634952
134embryonic retina morphogenesis in camera-type eye (GO:0060059)3.21034239
135peptidyl-glutamic acid modification (GO:0018200)3.18570576
136glutamine family amino acid biosynthetic process (GO:0009084)3.11613701
137neutral lipid catabolic process (GO:0046461)3.09171566
138acylglycerol catabolic process (GO:0046464)3.09171566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.83641620
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.68021294
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.34828821
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.19838663
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.07837576
6* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.01355465
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.64408100
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.77082626
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.67305185
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3925456
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99225989
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96542123
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.94865084
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71537257
15CLOCK_20551151_ChIP-Seq_293T_Human1.69512365
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.67020092
17HTT_18923047_ChIP-ChIP_STHdh_Human1.61944887
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47394347
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46775110
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34103905
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27964627
22GATA1_22025678_ChIP-Seq_K562_Human1.24233712
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18402649
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17867355
25RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08610360
26BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05695746
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04641786
28GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.04538733
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03825548
30POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02184347
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01852989
32NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98246902
33CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97110772
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95469117
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94578550
36RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94154826
37CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92773730
38* TCF4_18268006_ChIP-ChIP_LS174T_Human0.91725008
39TP63_17297297_ChIP-ChIP_HaCaT_Human0.90824294
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90493417
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90480404
42SMC4_20622854_ChIP-Seq_HELA_Human0.90076463
43STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.89484682
44ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86637391
45ESR2_21235772_ChIP-Seq_MCF-7_Human0.86295562
46GATA6_25053715_ChIP-Seq_YYC3_Human0.86071724
47HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85758589
48DROSHA_22980978_ChIP-Seq_HELA_Human0.85120863
49AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84973624
50SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84828766
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84450097
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84295428
53ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84283166
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84017516
55* ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83608594
56AR_21572438_ChIP-Seq_LNCaP_Human0.83175935
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83135018
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77931488
59NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77931488
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.77338059
61* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.76043628
62SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73848772
63SOX2_20726797_ChIP-Seq_SW620_Human0.73520279
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.72347297
65RARB_27405468_Chip-Seq_BRAIN_Mouse0.71735939
66SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71689614
67RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71405547
68GATA4_25053715_ChIP-Seq_YYC3_Human0.70058736
69KDM2B_26808549_Chip-Seq_K562_Human0.67647088
70BCAT_22108803_ChIP-Seq_LS180_Human0.67527244
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.67452153
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.66930105
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.66183574
74* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65454015
75KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65440396
76RARA_24833708_ChIP-Seq_LIVER_Mouse0.65399678
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.62296855
78ERG_21242973_ChIP-ChIP_JURKAT_Human0.62091556
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.61976433
80SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.61688954
81* CTCF_27219007_Chip-Seq_Bcells_Human0.61100618
82P68_20966046_ChIP-Seq_HELA_Human0.60724040
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60624781
84MTF2_20144788_ChIP-Seq_MESCs_Mouse0.60602246
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.59882332
86EZH2_18974828_ChIP-Seq_MESCs_Mouse0.59707043
87RNF2_18974828_ChIP-Seq_MESCs_Mouse0.59707043
88* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.59420205
89* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.59210594
90SOX2_21211035_ChIP-Seq_LN229_Human0.59000108
91* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.58965570
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.58903451
93SALL4_18804426_ChIP-ChIP_XEN_Mouse0.58162144
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.57962717
95SMAD1_18555785_Chip-Seq_ESCs_Mouse0.57888715
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57268315
97* LXR_22292898_ChIP-Seq_THP-1_Human0.57118510
98CBP_21632823_ChIP-Seq_H3396_Human0.57044902
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.56445021
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.56181003
101* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56045596
102MYC_19915707_ChIP-ChIP_AK7_Human0.55209238
103FOXA1_25552417_ChIP-Seq_VCAP_Human0.54816225
104MYC_27129775_Chip-Seq_CORNEA_Mouse0.53413498
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53168835
106RARB_24833708_ChIP-Seq_LIVER_Mouse0.52527087
107* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52489692
108ZNF263_19887448_ChIP-Seq_K562_Human0.52241155
109PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.51882186
110CEBPB_22108803_ChIP-Seq_LS180_Human0.51088383
111GATA1_19941826_ChIP-Seq_K562_Human0.50748573
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.50086851
113* AR_20517297_ChIP-Seq_VCAP_Human0.49678031
114P53_21459846_ChIP-Seq_SAOS-2_Human0.49434831
115* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.48883430
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48698493
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.48594827
118TAF2_19829295_ChIP-Seq_ESCs_Human0.48521996
119* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48301602
120ESET_19884257_ChIP-Seq_ESCs_Mouse0.46922651
121PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46281563
122TAF15_26573619_Chip-Seq_HEK293_Human0.43913473
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.43847452
124GATA2_19941826_ChIP-Seq_K562_Human0.43472309
125IRF8_22096565_ChIP-ChIP_GC-B_Human0.43272129
126STAT1_17558387_ChIP-Seq_HELA_Human0.42951495
127FOXH1_21741376_ChIP-Seq_EPCs_Human0.42087333
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.42065298
129EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.41782731
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.41600217
131EGR1_19032775_ChIP-ChIP_M12_Human0.41451661
132EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.41386921
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.40648446
134FOXO3_23340844_ChIP-Seq_DLD1_Human0.40600898
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.40579104
136PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.40436038
137CDX2_20551321_ChIP-Seq_CACO-2_Human0.39662747
138TRIM28_21343339_ChIP-Seq_HEK293_Human0.38880665
139CSB_26484114_Chip-Seq_FIBROBLAST_Human0.36898933
140LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36809814
141P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.36801347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.02569137
2MP0005360_urolithiasis7.49724263
3MP0005085_abnormal_gallbladder_physiolo6.15336075
4MP0005365_abnormal_bile_salt5.99695441
5MP0008875_abnormal_xenobiotic_pharmacok4.92024378
6MP0003806_abnormal_nucleotide_metabolis3.89625416
7MP0010329_abnormal_lipoprotein_level3.75965084
8MP0003252_abnormal_bile_duct3.65217255
9MP0003122_maternal_imprinting3.53783941
10MP0009840_abnormal_foam_cell3.52649214
11MP0005083_abnormal_biliary_tract2.92753003
12* MP0005332_abnormal_amino_acid2.90686206
13MP0003195_calcinosis2.84376486
14MP0003191_abnormal_cellular_cholesterol2.51622259
15MP0001666_abnormal_nutrient_absorption2.47091143
16MP0000566_synostosis2.33747487
17MP0004019_abnormal_vitamin_homeostasis2.19844230
18MP0002118_abnormal_lipid_homeostasis2.18463746
19MP0000609_abnormal_liver_physiology2.11626839
20MP0003123_paternal_imprinting1.86505320
21MP0002138_abnormal_hepatobiliary_system1.74830719
22MP0003868_abnormal_feces_composition1.74664652
23* MP0005319_abnormal_enzyme/_coenzyme1.71550531
24MP0003172_abnormal_lysosome_physiology1.69826943
25MP0001915_intracranial_hemorrhage1.68595765
26MP0005584_abnormal_enzyme/coenzyme_acti1.65844538
27MP0001764_abnormal_homeostasis1.63135140
28MP0003011_delayed_dark_adaptation1.56827921
29MP0009697_abnormal_copulation1.52198274
30MP0005670_abnormal_white_adipose1.43834033
31MP0003879_abnormal_hair_cell1.42555417
32MP0005451_abnormal_body_composition1.33630436
33MP0000604_amyloidosis1.32721321
34MP0003690_abnormal_glial_cell1.31813548
35MP0002254_reproductive_system_inflammat1.29490440
36MP0009643_abnormal_urine_homeostasis1.29261471
37MP0003186_abnormal_redox_activity1.23461348
38MP0000920_abnormal_myelination1.20712043
39MP0003656_abnormal_erythrocyte_physiolo1.19167643
40MP0002132_abnormal_respiratory_system1.16024105
41MP0005647_abnormal_sex_gland1.14426178
42MP0003705_abnormal_hypodermis_morpholog1.13109292
43MP0009764_decreased_sensitivity_to1.08689918
44MP0005409_darkened_coat_color1.06305774
45MP0004270_analgesia1.04778744
46* MP0000598_abnormal_liver_morphology1.03820873
47MP0003329_amyloid_beta_deposits1.01611629
48MP0005636_abnormal_mineral_homeostasis0.98376060
49MP0009763_increased_sensitivity_to0.97955052
50MP0004130_abnormal_muscle_cell0.95512714
51MP0003632_abnormal_nervous_system0.91982586
52MP0002876_abnormal_thyroid_physiology0.88317759
53MP0001661_extended_life_span0.86742457
54MP0002078_abnormal_glucose_homeostasis0.86573175
55MP0003183_abnormal_peptide_metabolism0.86542543
56MP0009384_cardiac_valve_regurgitation0.86341325
57* MP0009642_abnormal_blood_homeostasis0.85524819
58MP0002971_abnormal_brown_adipose0.81420333
59MP0008469_abnormal_protein_level0.79860895
60MP0005376_homeostasis/metabolism_phenot0.79622481
61MP0005535_abnormal_body_temperature0.78977175
62MP0002909_abnormal_adrenal_gland0.77904718
63* MP0002089_abnormal_postnatal_growth/wei0.76224592
64MP0003075_altered_response_to0.75970802
65MP0003121_genomic_imprinting0.75762466
66MP0010368_abnormal_lymphatic_system0.75674076
67MP0006036_abnormal_mitochondrial_physio0.75578737
68MP0005334_abnormal_fat_pad0.74612609
69MP0000639_abnormal_adrenal_gland0.72577528
70MP0005084_abnormal_gallbladder_morpholo0.69076856
71MP0009765_abnormal_xenobiotic_induced0.69030523
72MP0004272_abnormal_basement_membrane0.68628419
73MP0005408_hypopigmentation0.67426720
74MP0005666_abnormal_adipose_tissue0.65589942
75MP0004043_abnormal_pH_regulation0.64610739
76* MP0003631_nervous_system_phenotype0.62982402
77MP0005448_abnormal_energy_balance0.62171277
78MP0005266_abnormal_metabolism0.57281911
79MP0005220_abnormal_exocrine_pancreas0.57277842
80* MP0001756_abnormal_urination0.57127195
81MP0002837_dystrophic_cardiac_calcinosis0.55261915
82MP0002064_seizures0.55174870
83MP0000003_abnormal_adipose_tissue0.54910344
84MP0001270_distended_abdomen0.52760197
85MP0002249_abnormal_larynx_morphology0.51853634
86MP0002822_catalepsy0.51840558
87MP0005551_abnormal_eye_electrophysiolog0.51776238
88MP0004885_abnormal_endolymph0.51602259
89MP0003638_abnormal_response/metabolism_0.51355695
90MP0009053_abnormal_anal_canal0.50656146
91MP0003115_abnormal_respiratory_system0.50422965
92MP0005395_other_phenotype0.50012271
93MP0003953_abnormal_hormone_level0.49836814
94MP0003950_abnormal_plasma_membrane0.49272579
95MP0005257_abnormal_intraocular_pressure0.49167677
96MP0003878_abnormal_ear_physiology0.49116969
97MP0005377_hearing/vestibular/ear_phenot0.49116969
98MP0008874_decreased_physiological_sensi0.48815915
99MP0002282_abnormal_trachea_morphology0.46993698
100MP0008872_abnormal_physiological_respon0.46948791
101MP0005166_decreased_susceptibility_to0.46939057
102MP0008569_lethality_at_weaning0.46795550
103MP0002136_abnormal_kidney_physiology0.46677627
104MP0002933_joint_inflammation0.45805985
105MP0000230_abnormal_systemic_arterial0.44676012
106MP0003634_abnormal_glial_cell0.44049853
107MP0003567_abnormal_fetal_cardiomyocyte0.43269274
108MP0006054_spinal_hemorrhage0.41196054
109MP0004883_abnormal_blood_vessel0.40960854
110MP0002168_other_aberrant_phenotype0.40819932
111MP0006035_abnormal_mitochondrial_morpho0.40460556
112MP0001853_heart_inflammation0.39664357
113MP0005464_abnormal_platelet_physiology0.39438291
114MP0000579_abnormal_nail_morphology0.37877088
115MP0005058_abnormal_lysosome_morphology0.37009416
116MP0003724_increased_susceptibility_to0.36901358
117MP0001881_abnormal_mammary_gland0.36564124
118MP0001984_abnormal_olfaction0.36295139
119MP0005164_abnormal_response_to0.36252824
120MP0001486_abnormal_startle_reflex0.36094296
121MP0005410_abnormal_fertilization0.35950740
122MP0005023_abnormal_wound_healing0.35614868
123MP0005595_abnormal_vascular_smooth0.35493075
124* MP0003633_abnormal_nervous_system0.35006658
125MP0003566_abnormal_cell_adhesion0.34920891
126MP0001324_abnormal_eye_pigmentation0.34735673
127MP0002090_abnormal_vision0.33918312
128* MP0009115_abnormal_fat_cell0.33660280
129MP0002557_abnormal_social/conspecific_i0.33529544
130MP0009672_abnormal_birth_weight0.33436922
131MP0003718_maternal_effect0.33170795
132MP0002796_impaired_skin_barrier0.33163991
133MP0008873_increased_physiological_sensi0.33056090
134MP0005248_abnormal_Harderian_gland0.32835481
135* MP0000249_abnormal_blood_vessel0.32240524
136MP0005646_abnormal_pituitary_gland0.32199191
137MP0002970_abnormal_white_adipose0.31293424
138MP0009780_abnormal_chondrocyte_physiolo0.29848630
139MP0002928_abnormal_bile_duct0.26622690
140MP0004782_abnormal_surfactant_physiolog0.26590818

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.16470541
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.10357694
3Intrahepatic cholestasis (HP:0001406)6.89702632
4Xanthomatosis (HP:0000991)6.37030193
5Prolonged partial thromboplastin time (HP:0003645)6.36075893
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.23350697
7Hypobetalipoproteinemia (HP:0003563)6.01838180
8Hyperlipoproteinemia (HP:0010980)5.80771827
9Complement deficiency (HP:0004431)5.22822567
10Hypolipoproteinemia (HP:0010981)4.93010050
11Joint hemorrhage (HP:0005261)4.78648151
12Hypoalphalipoproteinemia (HP:0003233)4.68105796
13Hyperammonemia (HP:0001987)4.63381577
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.48312091
15Hyperglycinemia (HP:0002154)4.38856336
16Ketosis (HP:0001946)4.38478074
17Abnormality of the common coagulation pathway (HP:0010990)4.35336702
18Epidermoid cyst (HP:0200040)4.34033447
19Abnormality of methionine metabolism (HP:0010901)4.30804834
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.26674988
21Hyperglycinuria (HP:0003108)4.20183539
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.14546227
23Abnormality of glycine metabolism (HP:0010895)4.09747224
24Abnormality of serine family amino acid metabolism (HP:0010894)4.09747224
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08672912
26Hypoglycemic coma (HP:0001325)4.00004833
27Fat malabsorption (HP:0002630)3.81231570
28Abnormality of complement system (HP:0005339)3.75977386
29Hypercholesterolemia (HP:0003124)3.62071881
30Abnormality of the intrinsic pathway (HP:0010989)3.58408124
31Abnormality of pyrimidine metabolism (HP:0004353)3.43740536
32Conjugated hyperbilirubinemia (HP:0002908)3.41041835
33Ketoacidosis (HP:0001993)3.36275152
34Abnormality of fatty-acid metabolism (HP:0004359)3.30365058
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22314535
36Hyperbilirubinemia (HP:0002904)3.20836581
37Delayed CNS myelination (HP:0002188)3.13178392
38Purpura (HP:0000979)3.12462077
39Nephritis (HP:0000123)3.02331721
40Spontaneous abortion (HP:0005268)2.96641082
41Abnormality of nucleobase metabolism (HP:0010932)2.93698599
42Abnormality of serum amino acid levels (HP:0003112)2.86744700
43Myocardial infarction (HP:0001658)2.85418262
44Steatorrhea (HP:0002570)2.82524463
45Hepatocellular carcinoma (HP:0001402)2.80615680
46Vascular calcification (HP:0004934)2.79941496
47Skin nodule (HP:0200036)2.76749104
48Amyloidosis (HP:0011034)2.73053438
49Metabolic acidosis (HP:0001942)2.72398161
50Abnormality of carpal bone ossification (HP:0006257)2.71567760
51Hypoglycemic seizures (HP:0002173)2.69492543
52Abnormality of purine metabolism (HP:0004352)2.68677630
53Lethargy (HP:0001254)2.62909681
54Systemic lupus erythematosus (HP:0002725)2.60033904
55Gout (HP:0001997)2.58925935
56Hypochromic microcytic anemia (HP:0004840)2.58767436
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53899436
58Dicarboxylic aciduria (HP:0003215)2.53899436
59Cardiovascular calcification (HP:0011915)2.48437428
60Abnormal tarsal ossification (HP:0008369)2.47085792
61Glomerulonephritis (HP:0000099)2.45528563
62Mitral stenosis (HP:0001718)2.40515571
63Small epiphyses (HP:0010585)2.38944855
64Acanthocytosis (HP:0001927)2.38723959
65Irritability (HP:0000737)2.35749762
66Arthropathy (HP:0003040)2.31686551
67Cerebral edema (HP:0002181)2.31683074
68Abnormal gallbladder morphology (HP:0012437)2.31499298
69Confusion (HP:0001289)2.31144297
70Neonatal onset (HP:0003623)2.29420097
71Spastic diplegia (HP:0001264)2.27112615
72Osteomalacia (HP:0002749)2.25597009
73Gingival bleeding (HP:0000225)2.25202971
74Cholelithiasis (HP:0001081)2.24895220
75Broad alveolar ridges (HP:0000187)2.23561497
76Sensorimotor neuropathy (HP:0007141)2.21486580
77Hyperinsulinemic hypoglycemia (HP:0000825)2.20664338
78Increased serum pyruvate (HP:0003542)2.19483853
79Late onset (HP:0003584)2.19231045
80Cholecystitis (HP:0001082)2.18969607
81Abnormal gallbladder physiology (HP:0012438)2.18969607
82Enlarged kidneys (HP:0000105)2.18481045
83Pulmonary embolism (HP:0002204)2.13007841
84Pancreatitis (HP:0001733)2.10699433
85Vomiting (HP:0002013)2.06670320
86Esophageal varix (HP:0002040)2.06609248
87Alacrima (HP:0000522)2.06136958
88Brushfield spots (HP:0001088)2.05692136
89Abnormality of glycolysis (HP:0004366)2.05636293
90Pancreatic islet-cell hyperplasia (HP:0004510)2.04988503
91Abnormality of the Achilles tendon (HP:0005109)2.04619127
92Flat acetabular roof (HP:0003180)2.04446202
93Recurrent gram-negative bacterial infections (HP:0005420)2.04279526
94Generalized aminoaciduria (HP:0002909)2.04014963
95Malnutrition (HP:0004395)2.02292861
96Alkalosis (HP:0001948)2.00228751
97Menorrhagia (HP:0000132)1.99918316
98Abnormal hand bone ossification (HP:0010660)1.99555659
99Status epilepticus (HP:0002133)1.99288176
100Abnormal ossification of hand bones (HP:0005921)1.99072519
101Thrombophlebitis (HP:0004418)1.98979888
102Vaginal fistula (HP:0004320)1.95734422
103Asymmetry of the thorax (HP:0001555)1.94558695
104Hemorrhage of the eye (HP:0011885)1.93159594
105Abnormality of the lumbar spine (HP:0100712)1.91341686
106Opisthotonus (HP:0002179)1.91032310
107Abnormality of the gallbladder (HP:0005264)1.90585042
108Abnormality of proline metabolism (HP:0010907)1.90341491
109Hydroxyprolinuria (HP:0003080)1.90341491
110Rickets (HP:0002748)1.89377559
111Tetraplegia (HP:0002445)1.89234875
112Hypertriglyceridemia (HP:0002155)1.87352010
113Hypophosphatemic rickets (HP:0004912)1.86084405
114Bifid scrotum (HP:0000048)1.86037397
115Poikilocytosis (HP:0004447)1.85100781
116Hepatoblastoma (HP:0002884)1.84911248
117Back pain (HP:0003418)1.80838771
118Hyperglycemia (HP:0003074)1.79365765
119Hyperuricemia (HP:0002149)1.78640550
120Increased purine levels (HP:0004368)1.78640550
121Broad palm (HP:0001169)1.77405076
122Impaired pain sensation (HP:0007328)1.76498912
123Abnormality of pain sensation (HP:0010832)1.76498912
124Epiphyseal dysplasia (HP:0002656)1.75981968
125Symptomatic seizures (HP:0011145)1.75834535
126Abnormality of transition element cation homeostasis (HP:0011030)1.75558318
127Scanning speech (HP:0002168)1.69616110
128Retinal atrophy (HP:0001105)1.69483891
129Abnormality of the nasal septum (HP:0000419)1.69430370
130Neurofibrillary tangles (HP:0002185)1.61177989
131Abnormal delivery (HP:0001787)1.60291884
132Neonatal death (HP:0003811)1.59217680
133Pigmentary retinal degeneration (HP:0001146)1.58701103
134Bronchomalacia (HP:0002780)1.58316062
135Epistaxis (HP:0000421)1.56874215
136Hypoplasia of the capital femoral epiphysis (HP:0003090)1.56503586
137Prenatal maternal abnormality (HP:0002686)1.49978976
138Mucopolysacchariduria (HP:0008155)1.49625384
139Urinary glycosaminoglycan excretion (HP:0003541)1.49625384
140Flared iliac wings (HP:0002869)1.49152350

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.69982786
2SIK14.74815025
3FGFR44.16893770
4ERN14.12109266
5INSRR3.17056808
6TYRO32.88717548
7NTRK32.75628807
8WNK42.56192032
9ERBB42.55837909
10TAOK32.46230290
11MAP2K42.27125647
12MST1R1.97550214
13CDK121.96502248
14TRIB31.95402913
15MAPK111.91246984
16PKN21.84512212
17FGFR11.78260073
18FLT31.66626376
19PIK3CG1.62586569
20CAMK1D1.53819578
21DAPK21.45199578
22LATS11.41150115
23PINK11.41115972
24WNK11.40421757
25PTK61.39802959
26SIK21.39764398
27MAPK121.38882898
28FGFR21.31771151
29PRKAA21.27866090
30MAP3K21.25484601
31TYK21.19348992
32JAK21.19108710
33AKT31.18886738
34ABL21.18292527
35FRK1.07988353
36DDR21.06097930
37KSR21.04046918
38SGK11.03222988
39MAPK41.01982333
40MAP3K71.01928466
41SGK31.00970503
42EEF2K1.00566586
43SGK20.97666222
44CAMK1G0.96947488
45NEK90.96257546
46STK38L0.96064519
47CAMK2G0.95488282
48PRKCZ0.92604919
49PRKACG0.91744580
50JAK10.91411784
51MAPK150.91026125
52MET0.90625760
53KDR0.86057897
54GRK60.85629839
55PRKAA10.84676525
56SGK2230.83826516
57SGK4940.83826516
58RIPK10.83067723
59ERBB20.82110947
60MARK10.80974110
61MAPK70.78808493
62PRKCG0.77365676
63UHMK10.73331234
64FGR0.72782389
65RPS6KB10.72608011
66IRAK30.72400516
67EPHB10.70139813
68FGFR30.69110328
69BRSK10.68971374
70EPHA40.68317979
71EPHA30.67565054
72CSNK1E0.66511070
73LMTK20.64139255
74TIE10.63837965
75GSK3A0.63795839
76PDPK10.63274988
77IGF1R0.63222603
78TBK10.61675476
79DYRK1B0.61485563
80MARK20.59278148
81PHKG10.58817774
82PHKG20.58817774
83EIF2AK10.58360998
84PDK40.57821626
85PDK30.57821626
86MAPKAPK30.57709775
87MAP2K30.57561261
88CDK60.57040027
89MAP3K30.56449430
90LATS20.55990130
91PTK20.53783245
92RPS6KA30.53327299
93CDC42BPA0.52469434
94CSK0.52076021
95TNK20.52057912
96MAPK100.50968849
97CSNK1D0.50252951
98PRKCQ0.49781143
99PDGFRA0.49360949
100SRC0.49231352
101EPHA20.48882619
102PRKG10.48800082
103RET0.48453656
104MTOR0.47970012
105MAP2K10.47687168
106STK380.46855986
107PRKD30.45754302
108MAP2K60.45532832
109NTRK20.44808887
110PKN10.44794643
111NEK60.44198266
112PIK3CA0.44186504
113PRKCA0.43441269
114BMX0.43200693
115NTRK10.43132133
116MAP3K130.42465436
117CDK50.42226933
118MINK10.42128346
119MAP3K90.40479409
120PAK30.39851650
121PDK10.39770304
122WNK30.38781987
123SMG10.37619192
124TGFBR20.34437941
125MAP3K140.34157694
126PDGFRB0.34156788
127CSNK1G10.33807479
128MAP3K10.33788342
129CAMK40.33718963
130CSF1R0.33450135
131MAP3K110.33294434
132IRAK20.32669079
133ALK0.32200792
134CAMK2D0.32057131
135CAMK2B0.31430531
136STK390.31347404
137PRKCH0.31296629
138CDK150.30716797
139CAMKK10.30290936
140EGFR0.30110904
141PRKACA0.30063944
142ICK0.30031000
143CDK70.29905728

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.30687337
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.24343687
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17530306
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10322095
5Arginine biosynthesis_Homo sapiens_hsa002203.07642470
6Complement and coagulation cascades_Homo sapiens_hsa046102.68786273
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65195392
8Fatty acid degradation_Homo sapiens_hsa000712.61108146
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60414457
10Tryptophan metabolism_Homo sapiens_hsa003802.56379714
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49135201
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43915767
13Butanoate metabolism_Homo sapiens_hsa006502.17240662
14Peroxisome_Homo sapiens_hsa041462.07634280
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05363926
16PPAR signaling pathway_Homo sapiens_hsa033202.05217139
17Propanoate metabolism_Homo sapiens_hsa006402.03073137
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00317174
19Fatty acid metabolism_Homo sapiens_hsa012122.00250685
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.81930144
21Chemical carcinogenesis_Homo sapiens_hsa052041.81584459
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78243155
23Histidine metabolism_Homo sapiens_hsa003401.78222706
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.74706624
25beta-Alanine metabolism_Homo sapiens_hsa004101.72220922
26Bile secretion_Homo sapiens_hsa049761.70260855
27Staphylococcus aureus infection_Homo sapiens_hsa051501.67858554
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58484437
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57856212
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56010799
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.54506318
32Retinol metabolism_Homo sapiens_hsa008301.53911933
33Caffeine metabolism_Homo sapiens_hsa002321.52027547
34Phenylalanine metabolism_Homo sapiens_hsa003601.51455125
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48697668
36Selenocompound metabolism_Homo sapiens_hsa004501.41422423
37Tyrosine metabolism_Homo sapiens_hsa003501.38809248
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38367793
39Sulfur metabolism_Homo sapiens_hsa009201.35785940
40Pyruvate metabolism_Homo sapiens_hsa006201.35728659
41Fatty acid elongation_Homo sapiens_hsa000621.30949432
42Steroid biosynthesis_Homo sapiens_hsa001001.28507762
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.27034229
44Starch and sucrose metabolism_Homo sapiens_hsa005001.21995562
45Fat digestion and absorption_Homo sapiens_hsa049751.19597259
46Biosynthesis of amino acids_Homo sapiens_hsa012301.19441819
47ABC transporters_Homo sapiens_hsa020101.15236402
48Carbon metabolism_Homo sapiens_hsa012001.12959770
49Other glycan degradation_Homo sapiens_hsa005111.06692192
50Folate biosynthesis_Homo sapiens_hsa007901.04120083
51Fatty acid biosynthesis_Homo sapiens_hsa000611.02314655
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00357034
53Arginine and proline metabolism_Homo sapiens_hsa003301.00052715
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.96574480
55Vitamin digestion and absorption_Homo sapiens_hsa049770.96509828
56Vitamin B6 metabolism_Homo sapiens_hsa007500.92999179
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85850895
58Sulfur relay system_Homo sapiens_hsa041220.85667358
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.84237959
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83223100
61Glycerolipid metabolism_Homo sapiens_hsa005610.81683056
62Lysine degradation_Homo sapiens_hsa003100.78693888
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71213646
64Glutathione metabolism_Homo sapiens_hsa004800.58876857
65Pentose phosphate pathway_Homo sapiens_hsa000300.57227678
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55827981
67One carbon pool by folate_Homo sapiens_hsa006700.50305399
68Pertussis_Homo sapiens_hsa051330.46658573
69Metabolic pathways_Homo sapiens_hsa011000.45738979
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37790064
71N-Glycan biosynthesis_Homo sapiens_hsa005100.34409321
72Prion diseases_Homo sapiens_hsa050200.33877640
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.30940063
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.30776104
75Linoleic acid metabolism_Homo sapiens_hsa005910.30237140
76Fructose and mannose metabolism_Homo sapiens_hsa000510.29294166
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26866216
78Insulin resistance_Homo sapiens_hsa049310.25612670
79Galactose metabolism_Homo sapiens_hsa000520.25530605
80Sphingolipid metabolism_Homo sapiens_hsa006000.20996733
81Glucagon signaling pathway_Homo sapiens_hsa049220.15520010
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14076305
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.11354392
84ECM-receptor interaction_Homo sapiens_hsa045120.06800783
85AMPK signaling pathway_Homo sapiens_hsa041520.03428812
86Type II diabetes mellitus_Homo sapiens_hsa04930-0.2105014
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.2015533
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1991406
89Regulation of autophagy_Homo sapiens_hsa04140-0.1903689
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1810045
91Lysosome_Homo sapiens_hsa04142-0.1787436
92Protein digestion and absorption_Homo sapiens_hsa04974-0.1667142
93Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1521086
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1398221
95GABAergic synapse_Homo sapiens_hsa04727-0.1282056
96African trypanosomiasis_Homo sapiens_hsa05143-0.1252249
97Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1087504
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1032657
99Mineral absorption_Homo sapiens_hsa04978-0.0981264
100Ether lipid metabolism_Homo sapiens_hsa00565-0.0949042
101Insulin signaling pathway_Homo sapiens_hsa04910-0.0700826
102Amoebiasis_Homo sapiens_hsa05146-0.0673326
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0658167
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0391347
105Insulin secretion_Homo sapiens_hsa04911-0.0317071
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0295245
107Glutamatergic synapse_Homo sapiens_hsa04724-0.0289203
108Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0285658
109Long-term potentiation_Homo sapiens_hsa04720-0.0270276
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0250470
111Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0145673
112Circadian rhythm_Homo sapiens_hsa04710-0.0075070

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