AGTPBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.65949425
2synaptic vesicle maturation (GO:0016188)5.21615758
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.17527701
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.00995701
5synaptic vesicle exocytosis (GO:0016079)4.93932275
6locomotory exploration behavior (GO:0035641)4.90593122
7positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.86331606
8vocalization behavior (GO:0071625)4.82745119
9positive regulation of gamma-delta T cell activation (GO:0046645)4.81362158
10glutamate secretion (GO:0014047)4.71997111
11regulation of B cell receptor signaling pathway (GO:0050855)4.55470309
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.54162255
13regulation of synaptic vesicle exocytosis (GO:2000300)4.51707854
14detection of molecule of bacterial origin (GO:0032490)4.50241688
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.47474933
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.47474933
17modulation by symbiont of host immune response (GO:0052553)4.47474933
18positive regulation by symbiont of host defense response (GO:0052509)4.47474933
19modulation by symbiont of host defense response (GO:0052031)4.47474933
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.47474933
21protein localization to synapse (GO:0035418)4.44942596
22cellular extravasation (GO:0045123)4.30088430
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.28929673
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.28439764
25neuronal action potential propagation (GO:0019227)4.26658735
26regulation of glutamate receptor signaling pathway (GO:1900449)4.26101753
27activated T cell proliferation (GO:0050798)4.25083470
28microglial cell activation (GO:0001774)4.24594314
29neuron cell-cell adhesion (GO:0007158)4.16585087
30regulation of synaptic vesicle transport (GO:1902803)4.13675276
31negative regulation of cell killing (GO:0031342)4.13043957
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.13043957
33neutrophil mediated immunity (GO:0002446)4.10656843
34exploration behavior (GO:0035640)3.98052714
35glutamate receptor signaling pathway (GO:0007215)3.96118319
36layer formation in cerebral cortex (GO:0021819)3.95143059
37neutrophil activation involved in immune response (GO:0002283)3.94790295
38neurotransmitter secretion (GO:0007269)3.92325831
39detection of other organism (GO:0098543)3.91560202
40synaptic transmission, glutamatergic (GO:0035249)3.90532202
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83270498
42regulation of synapse structural plasticity (GO:0051823)3.82901307
43macrophage activation involved in immune response (GO:0002281)3.82209258
44regulation of neuronal synaptic plasticity (GO:0048168)3.80774372
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.80638355
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.80509265
47cellular potassium ion homeostasis (GO:0030007)3.77667043
48neuron-neuron synaptic transmission (GO:0007270)3.77079797
49phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.74395412
50positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.74056076
51myeloid leukocyte mediated immunity (GO:0002444)3.68118663
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64845352
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.60700397
54respiratory burst (GO:0045730)3.60609260
55detection of external biotic stimulus (GO:0098581)3.60109947
56leukocyte migration involved in inflammatory response (GO:0002523)3.59035513
57pyrimidine nucleobase catabolic process (GO:0006208)3.58003448
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57032709
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54896173
60neural tube formation (GO:0001841)3.54524683
61membrane depolarization during action potential (GO:0086010)3.51810939
62positive regulation of mast cell activation (GO:0033005)3.50687329
63gamma-aminobutyric acid transport (GO:0015812)3.49751846
64long-term memory (GO:0007616)3.49618832
65proline transport (GO:0015824)3.46856366
66histone H3-K36 demethylation (GO:0070544)3.44075287
67regulation of postsynaptic membrane potential (GO:0060078)3.43358822
68macrophage activation (GO:0042116)3.43247178
69synaptic vesicle endocytosis (GO:0048488)3.42646621
70response to peptidoglycan (GO:0032494)3.40189872
71dendritic spine morphogenesis (GO:0060997)3.39686686
72positive regulation of synapse maturation (GO:0090129)3.38542893
73activation of protein kinase A activity (GO:0034199)3.37662122
74neurotransmitter-gated ion channel clustering (GO:0072578)3.36817839
75sodium ion export (GO:0071436)3.34370062
76positive regulation of membrane potential (GO:0045838)3.34336161
77neuron recognition (GO:0008038)3.31737901
78detection of biotic stimulus (GO:0009595)3.30709593
79cell communication by electrical coupling (GO:0010644)3.30652292
80neurotransmitter transport (GO:0006836)3.26573144
81detection of bacterium (GO:0016045)3.25888014
82B cell receptor signaling pathway (GO:0050853)3.25026593
83gamma-aminobutyric acid signaling pathway (GO:0007214)3.24814512
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23113640
85response to host immune response (GO:0052572)3.23113640
86regulation of neurotransmitter secretion (GO:0046928)3.21998702
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20478623
88negative regulation of lymphocyte mediated immunity (GO:0002707)3.19589249
89detection of calcium ion (GO:0005513)3.18993171
90positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.16815909
91regulation of dendritic spine morphogenesis (GO:0061001)3.16125878
92vesicle transport along microtubule (GO:0047496)3.15526564
93transmission of nerve impulse (GO:0019226)3.15268675
94membrane depolarization (GO:0051899)3.15032594
95regulation of gamma-delta T cell activation (GO:0046643)3.14366404
96nuclear pore complex assembly (GO:0051292)3.14160719
97presynaptic membrane assembly (GO:0097105)3.13186057
98regulation of synaptic plasticity (GO:0048167)3.12433044
99regulation of synaptic transmission, glutamatergic (GO:0051966)3.11464068
100nerve growth factor signaling pathway (GO:0038180)3.10318732
101* cerebellar Purkinje cell differentiation (GO:0021702)3.10272423
102negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08790435
103negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.08747155
104neutrophil activation (GO:0042119)3.08735883
105innervation (GO:0060384)3.08431661
106regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.07765458
107dendrite morphogenesis (GO:0048813)3.06588362
108regulation of vesicle fusion (GO:0031338)3.05990872
109axonal fasciculation (GO:0007413)3.04890795
110leukocyte aggregation (GO:0070486)3.03929089
111regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.03737327
112positive regulation of potassium ion transmembrane transport (GO:1901381)3.03549000
113positive regulation of mast cell degranulation (GO:0043306)3.01578147
114positive regulation of mast cell activation involved in immune response (GO:0033008)3.01578147
115regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.98487017
116regulation of voltage-gated calcium channel activity (GO:1901385)2.98428154
117negative regulation of T cell mediated immunity (GO:0002710)2.98252432
118negative regulation of interleukin-12 production (GO:0032695)2.98220941
119regulation of ARF protein signal transduction (GO:0032012)2.97854783
120neuromuscular process controlling balance (GO:0050885)2.97036553
121monoubiquitinated protein deubiquitination (GO:0035520)2.96485206
122positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.96344314
123presynaptic membrane organization (GO:0097090)2.95949512
124myeloid cell activation involved in immune response (GO:0002275)2.95726178
125membrane hyperpolarization (GO:0060081)2.95676687
126calcium ion-dependent exocytosis (GO:0017156)2.95204200
127regulation of neurotransmitter transport (GO:0051588)2.94676577
128long-term synaptic potentiation (GO:0060291)2.94052426
129establishment of nucleus localization (GO:0040023)2.93949449
130positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.91620888
131behavioral defense response (GO:0002209)2.91133716
132behavioral fear response (GO:0001662)2.91133716
133pre-miRNA processing (GO:0031054)2.90561139
134organelle transport along microtubule (GO:0072384)2.90285186
135positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.88637793
136* regulation of neurotransmitter levels (GO:0001505)2.86951529
137cell migration in hindbrain (GO:0021535)2.86676734
138histone H3-K9 demethylation (GO:0033169)2.85834873
139cell wall macromolecule catabolic process (GO:0016998)2.85163550
140prepulse inhibition (GO:0060134)2.84564021
141regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83999430
142negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83910703
143regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.83125952
144positive T cell selection (GO:0043368)2.82766281
145synapse assembly (GO:0007416)2.82746848
146intraspecies interaction between organisms (GO:0051703)2.81746907
147social behavior (GO:0035176)2.81746907
148response to histamine (GO:0034776)2.81438010
149negative regulation of immunoglobulin mediated immune response (GO:0002890)2.81370018
150negative regulation of B cell mediated immunity (GO:0002713)2.81370018
151neuromuscular process controlling posture (GO:0050884)2.80481844
152synaptic transmission (GO:0007268)2.80140251
153dosage compensation (GO:0007549)2.79934761
154learning (GO:0007612)2.78879370
155cerebellar granule cell differentiation (GO:0021707)2.78738051
156regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.78628352
157cytoplasmic mRNA processing body assembly (GO:0033962)2.78561192
158chemosensory behavior (GO:0007635)2.77719185
159positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77597553
160positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.77480505
161fear response (GO:0042596)2.77420653
162nuclear pore organization (GO:0006999)2.77375882
163glycine transport (GO:0015816)2.76893077
164positive regulation of synaptic transmission, GABAergic (GO:0032230)2.76792021
165positive regulation of neurotransmitter transport (GO:0051590)2.76444754
166negative regulation of NF-kappaB import into nucleus (GO:0042347)2.74550279
167regulation of mast cell activation (GO:0033003)2.73116125
168negative regulation of translation, ncRNA-mediated (GO:0040033)2.69329569
169regulation of translation, ncRNA-mediated (GO:0045974)2.69329569
170negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.69329569
171response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67315054
172response to host (GO:0075136)2.67315054
173response to host defenses (GO:0052200)2.67315054
174histone lysine demethylation (GO:0070076)2.66558074
175regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.64816768
176regulation of gamma-delta T cell differentiation (GO:0045586)2.63491578
177histone demethylation (GO:0016577)2.62978040
178histone mRNA catabolic process (GO:0071044)2.61903810
179negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.61429828
180response to muramyl dipeptide (GO:0032495)2.61011631
181negative regulation of B cell proliferation (GO:0030889)2.60228718
182granulocyte activation (GO:0036230)2.59305241
183regulation of Rap GTPase activity (GO:0032317)2.55632784
184regulation of NFAT protein import into nucleus (GO:0051532)2.55395814
185regulation of interferon-beta biosynthetic process (GO:0045357)2.55175495
186nucleobase catabolic process (GO:0046113)2.53483982
187production of molecular mediator involved in inflammatory response (GO:0002532)2.52691647
188regulation of MHC class II biosynthetic process (GO:0045346)2.51126301
189response to interleukin-15 (GO:0070672)2.51026320
190positive regulation of granulocyte differentiation (GO:0030854)2.47282111
191neutrophil chemotaxis (GO:0030593)2.46660407
192interferon-gamma production (GO:0032609)2.46504531
193pore complex assembly (GO:0046931)2.45885197
194histone H3-K4 trimethylation (GO:0080182)2.45833455
195positive regulation of interleukin-1 beta secretion (GO:0050718)2.45688028
196peptidyl-lysine trimethylation (GO:0018023)2.44847639
197negative regulation of neurotransmitter secretion (GO:0046929)2.44067103
198negative regulation of leukocyte mediated immunity (GO:0002704)2.43787144
199establishment of protein localization to Golgi (GO:0072600)2.42548855

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.16086617
2GBX2_23144817_ChIP-Seq_PC3_Human3.60483760
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.10688233
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.78588236
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.77053341
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73777977
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64314071
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62790889
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.50837451
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32309920
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32309920
12* DROSHA_22980978_ChIP-Seq_HELA_Human2.27982913
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26414412
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24472862
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22944287
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.21215899
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16633144
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.16356330
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16201248
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15277242
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.13784865
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09883275
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09780438
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.09346066
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07691065
26* EZH2_27294783_Chip-Seq_ESCs_Mouse1.96936912
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.95108156
28* REST_18959480_ChIP-ChIP_MESCs_Mouse1.94990839
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93874853
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.92499330
31SCL_19346495_ChIP-Seq_HPC-7_Human1.92189138
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89615277
33RUNX_20019798_ChIP-Seq_JUKART_Human1.88120423
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87561744
35TAF15_26573619_Chip-Seq_HEK293_Human1.87471793
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84055183
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.83723905
38SMAD4_21799915_ChIP-Seq_A2780_Human1.82195285
39* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81531627
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79508865
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78501942
42AR_21572438_ChIP-Seq_LNCaP_Human1.75866440
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.65925994
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65501824
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64109515
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61584667
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61551234
48* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60719677
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58782631
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.57599599
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.56474197
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55649624
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55541788
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54715535
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54007848
56MYB_26560356_Chip-Seq_TH2_Human1.50734291
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48681948
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48203377
59ZNF274_21170338_ChIP-Seq_K562_Hela1.47777562
60P300_19829295_ChIP-Seq_ESCs_Human1.45390571
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43757346
62EWS_26573619_Chip-Seq_HEK293_Human1.42309433
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42129290
64* STAT3_23295773_ChIP-Seq_U87_Human1.42034166
65* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40242091
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.39471445
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38882316
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38527963
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36490290
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36167299
71* SPI1_23547873_ChIP-Seq_NB4_Human1.36147587
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35872848
73* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35617341
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.35599002
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34503423
76* FLI1_21867929_ChIP-Seq_TH2_Mouse1.33673334
77* SMAD3_21741376_ChIP-Seq_EPCs_Human1.31668402
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31490048
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29975528
80* AR_25329375_ChIP-Seq_VCAP_Human1.29397093
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28923741
82* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28495821
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.27742453
84IRF8_22096565_ChIP-ChIP_GC-B_Human1.27403112
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27079417
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25534518
87* TCF4_23295773_ChIP-Seq_U87_Human1.25035991
88AR_19668381_ChIP-Seq_PC3_Human1.23228153
89* VDR_24787735_ChIP-Seq_THP-1_Human1.22266598
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21017137
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19999944
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.19343590
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.19269363
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17981137
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15874780
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.15495149
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15470994
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.14943135
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14863487
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14430858
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14293819
102* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13838360
103* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13806975
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11999867
105GATA3_27048872_Chip-Seq_THYMUS_Human1.11957395
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11060093
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11018809
108AHR_22903824_ChIP-Seq_MCF-7_Human1.11007409
109SALL4_22934838_ChIP-ChIP_CD34+_Human1.10535961
110SPI1_23127762_ChIP-Seq_K562_Human1.09635051
111* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09614604
112KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.08697426
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08447928
114CMYC_18555785_Chip-Seq_ESCs_Mouse1.08352308
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08277766
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08277766
117* PU_27001747_Chip-Seq_BMDM_Mouse1.07462667
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07278958
119* RING1B_27294783_Chip-Seq_ESCs_Mouse1.07073410
120* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06662715
121* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06413533
122VDR_22108803_ChIP-Seq_LS180_Human1.06071897
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05702347
124FUS_26573619_Chip-Seq_HEK293_Human1.05578706
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.05200463
126P53_22387025_ChIP-Seq_ESCs_Mouse1.04583841
127P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04508462
128PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03765914
129RNF2_27304074_Chip-Seq_NSC_Mouse1.03149238
130MYB_26560356_Chip-Seq_TH1_Human1.02947876
131HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02582543
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02429444
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02373498
134GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02345289
135NANOG_18555785_Chip-Seq_ESCs_Mouse1.02209613
136E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01791649
137EP300_21415370_ChIP-Seq_HL-1_Mouse1.01648640
138* RUNX2_22187159_ChIP-Seq_PCA_Human1.01136284
139ERG_21242973_ChIP-ChIP_JURKAT_Human1.01071080
140SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00333020
141TP53_16413492_ChIP-PET_HCT116_Human1.00150574
142PRDM14_20953172_ChIP-Seq_ESCs_Human1.00082325
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99849946
144* IGF1R_20145208_ChIP-Seq_DFB_Human0.99567237
145NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99336997
146BCAT_22108803_ChIP-Seq_LS180_Human0.99265142
147* SMAD3_21741376_ChIP-Seq_ESCs_Human0.98853837
148* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98778992
149EGR1_19374776_ChIP-ChIP_THP-1_Human0.98723287
150* ER_23166858_ChIP-Seq_MCF-7_Human0.97784229
151OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96917257
152SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96869469
153* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96595332
154* CBP_20019798_ChIP-Seq_JUKART_Human0.96595332
155MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95923313
156CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94829874
157SMAD4_21741376_ChIP-Seq_HESCs_Human0.94312647
158EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93971625
159SMAD3_21741376_ChIP-Seq_HESCs_Human0.93429903
160KDM2B_26808549_Chip-Seq_REH_Human0.92670202
161RING1B_27294783_Chip-Seq_NPCs_Mouse0.89621301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.97287679
2MP0003880_abnormal_central_pattern4.24818092
3MP0008057_abnormal_DNA_replication3.99116790
4MP0003635_abnormal_synaptic_transmissio3.89262780
5MP0004270_analgesia3.84907076
6MP0003724_increased_susceptibility_to3.65532272
7MP0009046_muscle_twitch3.17488179
8MP0009745_abnormal_behavioral_response3.14430276
9MP0002063_abnormal_learning/memory/cond3.10725445
10MP0002009_preneoplasia3.08959543
11MP0001968_abnormal_touch/_nociception3.01314518
12MP0002064_seizures2.88394905
13MP0002734_abnormal_mechanical_nocicepti2.78502226
14MP0002735_abnormal_chemical_nociception2.67747595
15MP0002572_abnormal_emotion/affect_behav2.63364795
16MP0002272_abnormal_nervous_system2.56900182
17MP0005423_abnormal_somatic_nervous2.55567080
18MP0001835_abnormal_antigen_presentation2.49429031
19MP0003303_peritoneal_inflammation2.44399760
20MP0008260_abnormal_autophagy2.43061751
21MP0001486_abnormal_startle_reflex2.39658460
22MP0003690_abnormal_glial_cell2.35996656
23MP0002736_abnormal_nociception_after2.27450639
24MP0002822_catalepsy2.18990545
25MP0003221_abnormal_cardiomyocyte_apopto2.13633673
26MP0001501_abnormal_sleep_pattern2.12866888
27MP0001440_abnormal_grooming_behavior2.09241162
28MP0003121_genomic_imprinting2.05414515
29MP0002733_abnormal_thermal_nociception2.03860483
30MP0002067_abnormal_sensory_capabilities2.02961881
31MP0001970_abnormal_pain_threshold1.99439733
32MP0008569_lethality_at_weaning1.87829525
33MP0002184_abnormal_innervation1.83683581
34MP0006276_abnormal_autonomic_nervous1.82272134
35MP0004924_abnormal_behavior1.81645120
36MP0005386_behavior/neurological_phenoty1.81645120
37MP0002419_abnormal_innate_immunity1.80948045
38MP0000778_abnormal_nervous_system1.79904374
39MP0001984_abnormal_olfaction1.78956776
40MP0001800_abnormal_humoral_immune1.76535769
41MP0009780_abnormal_chondrocyte_physiolo1.76341502
42MP0003828_pulmonary_edema1.76177516
43MP0004811_abnormal_neuron_physiology1.73314202
44MP0002909_abnormal_adrenal_gland1.69365830
45MP0002837_dystrophic_cardiac_calcinosis1.68816988
46MP0000569_abnormal_digit_pigmentation1.67298236
47MP0003329_amyloid_beta_deposits1.66221795
48MP0004858_abnormal_nervous_system1.63506200
49MP0002557_abnormal_social/conspecific_i1.62995024
50MP0003646_muscle_fatigue1.60843514
51MP0000751_myopathy1.56667134
52MP0005551_abnormal_eye_electrophysiolog1.55942755
53MP0004145_abnormal_muscle_electrophysio1.54744372
54MP0003787_abnormal_imprinting1.53551096
55MP0000955_abnormal_spinal_cord1.51769046
56MP0002420_abnormal_adaptive_immunity1.51360861
57MP0001819_abnormal_immune_cell1.47899318
58MP0003436_decreased_susceptibility_to1.46862523
59MP0005646_abnormal_pituitary_gland1.46760463
60MP0003172_abnormal_lysosome_physiology1.45157395
61MP0003656_abnormal_erythrocyte_physiolo1.44749762
62* MP0002882_abnormal_neuron_morphology1.44675677
63MP0000465_gastrointestinal_hemorrhage1.43596012
64MP0002398_abnormal_bone_marrow1.41344184
65MP0004215_abnormal_myocardial_fiber1.39948033
66MP0002723_abnormal_immune_serum1.38350164
67* MP0002066_abnormal_motor_capabilities/c1.35426791
68MP0002452_abnormal_antigen_presenting1.34854690
69MP0002166_altered_tumor_susceptibility1.34601665
70MP0003879_abnormal_hair_cell1.32738014
71MP0003633_abnormal_nervous_system1.32721826
72MP0003763_abnormal_thymus_physiology1.32625078
73MP0005671_abnormal_response_to1.32580181
74MP0001502_abnormal_circadian_rhythm1.30218038
75MP0005025_abnormal_response_to1.26885266
76MP0006082_CNS_inflammation1.25174988
77MP0000703_abnormal_thymus_morphology1.24419035
78MP0002396_abnormal_hematopoietic_system1.23693485
79MP0005000_abnormal_immune_tolerance1.23155097
80MP0005410_abnormal_fertilization1.21849283
81MP0000716_abnormal_immune_system1.21733332
82MP0009278_abnormal_bone_marrow1.20047176
83MP0005645_abnormal_hypothalamus_physiol1.18176065
84MP0005397_hematopoietic_system_phenotyp1.16869372
85MP0001545_abnormal_hematopoietic_system1.16869372
86MP0000689_abnormal_spleen_morphology1.16867752
87MP0010386_abnormal_urinary_bladder1.16840713
88MP0003631_nervous_system_phenotype1.14975042
89MP0001529_abnormal_vocalization1.14886517
90* MP0002229_neurodegeneration1.14431220
91MP0004885_abnormal_endolymph1.14390974
92MP0002722_abnormal_immune_system1.13654815
93MP0001905_abnormal_dopamine_level1.12368649
94MP0003183_abnormal_peptide_metabolism1.11524841
95MP0003890_abnormal_embryonic-extraembry1.11290102
96MP0004085_abnormal_heartbeat1.09683432
97MP0004484_altered_response_of1.06817235
98MP0003300_gastrointestinal_ulcer1.06787361
99* MP0002152_abnormal_brain_morphology1.05146375
100MP0004142_abnormal_muscle_tone1.04603350
101MP0005464_abnormal_platelet_physiology1.03797728
102MP0004233_abnormal_muscle_weight1.03460592
103MP0001851_eye_inflammation1.02761387
104MP0005075_abnormal_melanosome_morpholog1.00732922
105MP0005248_abnormal_Harderian_gland1.00354318
106MP0009785_altered_susceptibility_to0.96839601
107MP0002638_abnormal_pupillary_reflex0.96257794
108MP0001188_hyperpigmentation0.96133922
109MP0002332_abnormal_exercise_endurance0.92548585
110MP0004510_myositis0.92217884
111MP0006072_abnormal_retinal_apoptosis0.90286764
112MP0002429_abnormal_blood_cell0.89526076
113MP0002405_respiratory_system_inflammati0.89022233
114MP0004742_abnormal_vestibular_system0.86433094
115MP0004036_abnormal_muscle_relaxation0.86406211
116* MP0002752_abnormal_somatic_nervous0.85774930
117MP0004381_abnormal_hair_follicle0.85470916
118MP0005535_abnormal_body_temperature0.85103219
119MP0003137_abnormal_impulse_conducting0.83883506
120MP0003634_abnormal_glial_cell0.83261356
121MP0003632_abnormal_nervous_system0.83018848
122MP0002006_tumorigenesis0.82351609
123MP0004883_abnormal_blood_vessel0.82347842
124MP0008874_decreased_physiological_sensi0.81235475
125MP0004130_abnormal_muscle_cell0.81224727
126MP0000015_abnormal_ear_pigmentation0.79929242
127MP0004808_abnormal_hematopoietic_stem0.79002340
128MP0002069_abnormal_eating/drinking_beha0.78902718
129MP0005253_abnormal_eye_physiology0.78320678
130MP0005620_abnormal_muscle_contractility0.77098163
131MP0001790_abnormal_immune_system0.76852919
132MP0005387_immune_system_phenotype0.76852919
133MP0005310_abnormal_salivary_gland0.76781916
134MP0005174_abnormal_tail_pigmentation0.76680879
135MP0002133_abnormal_respiratory_system0.75393077
136MP0005388_respiratory_system_phenotype0.75393077
137MP0001299_abnormal_eye_distance/0.74869589
138MP0008058_abnormal_DNA_repair0.74844798
139MP0008961_abnormal_basal_metabolism0.74574062
140MP0003122_maternal_imprinting0.74369809
141MP0002090_abnormal_vision0.74239969
142MP0000920_abnormal_myelination0.73975334
143MP0008872_abnormal_physiological_respon0.73578410
144MP0003866_abnormal_defecation0.73271769
145MP0003567_abnormal_fetal_cardiomyocyte0.72985534
146MP0005394_taste/olfaction_phenotype0.71887225
147MP0005499_abnormal_olfactory_system0.71887225
148MP0000013_abnormal_adipose_tissue0.69790132
149MP0001177_atelectasis0.69076426
150MP0005187_abnormal_penis_morphology0.68896292
151MP0000631_abnormal_neuroendocrine_gland0.68269992
152MP0008877_abnormal_DNA_methylation0.67555800
153* MP0001963_abnormal_hearing_physiology0.66576517
154MP0002972_abnormal_cardiac_muscle0.64798844
155MP0000749_muscle_degeneration0.64334715
156* MP0003698_abnormal_male_reproductive0.63827380
157MP0000604_amyloidosis0.63338951
158MP0000747_muscle_weakness0.59978336
159MP0003045_fibrosis0.58656307
160MP0005409_darkened_coat_color0.58449488

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.10786556
2Myokymia (HP:0002411)5.92450652
3Focal seizures (HP:0007359)5.30244151
4Febrile seizures (HP:0002373)4.68927210
5Visual hallucinations (HP:0002367)4.64448734
6Epileptic encephalopathy (HP:0200134)4.58697135
7Recurrent bacterial skin infections (HP:0005406)4.49991898
8Progressive cerebellar ataxia (HP:0002073)4.47986768
9Atonic seizures (HP:0010819)4.39666289
10Action tremor (HP:0002345)4.06032839
11Recurrent abscess formation (HP:0002722)4.00333943
12Absence seizures (HP:0002121)3.92596510
13Papillary thyroid carcinoma (HP:0002895)3.85152645
14Gaze-evoked nystagmus (HP:0000640)3.60715742
15Generalized tonic-clonic seizures (HP:0002069)3.57695650
16Dialeptic seizures (HP:0011146)3.51871238
17Broad-based gait (HP:0002136)3.48167304
18Eczematoid dermatitis (HP:0000976)3.37512768
19Supranuclear gaze palsy (HP:0000605)3.30269499
20Truncal ataxia (HP:0002078)3.17080512
21Dysdiadochokinesis (HP:0002075)3.11579035
22Poor eye contact (HP:0000817)3.11523460
23Urinary bladder sphincter dysfunction (HP:0002839)3.06756670
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.05535186
25Retrobulbar optic neuritis (HP:0100654)3.03253195
26Optic neuritis (HP:0100653)3.03253195
27Hepatoblastoma (HP:0002884)2.99625807
28Hyperventilation (HP:0002883)2.97644021
29Ankle clonus (HP:0011448)2.93198218
30Genetic anticipation (HP:0003743)2.92735635
31Impaired vibration sensation in the lower limbs (HP:0002166)2.92338801
32Degeneration of the lateral corticospinal tracts (HP:0002314)2.91063986
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.91063986
34Hypochromic microcytic anemia (HP:0004840)2.90805166
35Dysmetria (HP:0001310)2.89207274
36T lymphocytopenia (HP:0005403)2.85383897
37Impaired social interactions (HP:0000735)2.84604338
38Abnormal social behavior (HP:0012433)2.84604338
39Stomatitis (HP:0010280)2.84055000
40Depression (HP:0000716)2.82498773
41Termporal pattern (HP:0011008)2.81192593
42Insidious onset (HP:0003587)2.81192593
43Drooling (HP:0002307)2.78864690
44Excessive salivation (HP:0003781)2.78864690
45Postural instability (HP:0002172)2.76731961
46Recurrent gram-negative bacterial infections (HP:0005420)2.75419726
47Thyroid carcinoma (HP:0002890)2.70396510
48Papilledema (HP:0001085)2.68030971
49Progressive inability to walk (HP:0002505)2.67364916
50Myositis (HP:0100614)2.66992770
51Dysmetric saccades (HP:0000641)2.66857106
52Subacute progressive viral hepatitis (HP:0006572)2.66746539
53Impaired smooth pursuit (HP:0007772)2.64856116
54Mutism (HP:0002300)2.62900869
55Amblyopia (HP:0000646)2.59632052
56Orchitis (HP:0100796)2.58083376
57Scanning speech (HP:0002168)2.57275216
58Pheochromocytoma (HP:0002666)2.55936570
59Central scotoma (HP:0000603)2.55898053
60Abnormality of the lower motor neuron (HP:0002366)2.54399942
61Abnormality of T cell number (HP:0011839)2.53579892
62Difficulty running (HP:0009046)2.53156942
63Recurrent skin infections (HP:0001581)2.52890570
64Agnosia (HP:0010524)2.52057642
65Volvulus (HP:0002580)2.50984738
66Urinary urgency (HP:0000012)2.50761762
67Chest pain (HP:0100749)2.50535670
68Anxiety (HP:0000739)2.49723606
69Medulloblastoma (HP:0002885)2.48150784
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.46122275
71Absent/shortened dynein arms (HP:0200106)2.46122275
72Abnormality of the corticospinal tract (HP:0002492)2.45910689
73Abnormal eating behavior (HP:0100738)2.42535296
74Bundle branch block (HP:0011710)2.42490598
75Abnormality of ocular smooth pursuit (HP:0000617)2.41845304
76Hemiparesis (HP:0001269)2.41683970
77Absent speech (HP:0001344)2.40867316
78Spastic gait (HP:0002064)2.39176825
79Ventricular fibrillation (HP:0001663)2.38995350
80Epileptiform EEG discharges (HP:0011182)2.38024270
81Abnormality of macrophages (HP:0004311)2.37491729
82Recurrent fungal infections (HP:0002841)2.37471939
83Keratoconjunctivitis sicca (HP:0001097)2.35276336
84Chronic mucocutaneous candidiasis (HP:0002728)2.31337558
85Recurrent cutaneous fungal infections (HP:0011370)2.31337558
86EEG with generalized epileptiform discharges (HP:0011198)2.29879147
87Intention tremor (HP:0002080)2.27991017
88Disinhibition (HP:0000734)2.25804385
89Encephalitis (HP:0002383)2.24014888
90Gastrointestinal infarctions (HP:0005244)2.23872717
91Keratoconjunctivitis (HP:0001096)2.22559749
92Syncope (HP:0001279)2.20712815
93Sudden death (HP:0001699)2.20514808
94Inability to walk (HP:0002540)2.19626921
95Viral hepatitis (HP:0006562)2.19160159
96Gingivitis (HP:0000230)2.17651975
97Abnormal hair whorl (HP:0010721)2.16732622
98Mediastinal lymphadenopathy (HP:0100721)2.16400208
99Neuroendocrine neoplasm (HP:0100634)2.15056742
100Hypsarrhythmia (HP:0002521)2.14520967
101Fetal akinesia sequence (HP:0001989)2.14135164
102Prolonged QT interval (HP:0001657)2.13697776
103Lower limb muscle weakness (HP:0007340)2.13138231
104Spontaneous hematomas (HP:0007420)2.11647038
105Amaurosis fugax (HP:0100576)2.11395615
106Stomach cancer (HP:0012126)2.10736167
107Bradykinesia (HP:0002067)2.10599378
108IgM deficiency (HP:0002850)2.10045926
109Stereotypic behavior (HP:0000733)2.10034930
110Abnormality of binocular vision (HP:0011514)2.08209346
111Diplopia (HP:0000651)2.08209346
112Abnormal EKG (HP:0003115)2.07948277
113Obstructive lung disease (HP:0006536)2.07810281
114Chronic obstructive pulmonary disease (HP:0006510)2.07810281
115Limb dystonia (HP:0002451)2.06391940
116Impaired vibratory sensation (HP:0002495)2.06216499
117Leukocytosis (HP:0001974)2.06152998
118Pelvic girdle muscle weakness (HP:0003749)2.05879520
119Transitional cell carcinoma of the bladder (HP:0006740)2.05505806
120Cerebral inclusion bodies (HP:0100314)2.05424378
121Neurofibrillary tangles (HP:0002185)2.04440653
122Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03478014
123Abnormality of macular pigmentation (HP:0008002)2.00655128
124Meningitis (HP:0001287)2.00638912
125Torticollis (HP:0000473)1.98901615
126Arterial thrombosis (HP:0004420)1.97773060
127Inappropriate behavior (HP:0000719)1.96928770
128Amyotrophic lateral sclerosis (HP:0007354)1.96033591
129Hemiplegia (HP:0002301)1.94310714
130Bladder neoplasm (HP:0009725)1.94304068
131Bladder carcinoma (HP:0002862)1.94304068
132Neoplasm of the tracheobronchial system (HP:0100552)1.93450553
133Megalencephaly (HP:0001355)1.93386709
134Gait ataxia (HP:0002066)1.92874649
135Agitation (HP:0000713)1.92573660
136Gingival bleeding (HP:0000225)1.92268808
137Abnormality of the left ventricular outflow tract (HP:0011103)1.90924199
138Subaortic stenosis (HP:0001682)1.90924199
139Hypoplasia of the brainstem (HP:0002365)1.88291181
140Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88291181
141Status epilepticus (HP:0002133)1.87362572
142Abnormal delayed hypersensitivity skin test (HP:0002963)1.87151458
143Abnormality of the hip-girdle musculature (HP:0001445)1.87114944
144Abnormality of the musculature of the pelvis (HP:0001469)1.87114944
145Abnormality of saccadic eye movements (HP:0000570)1.86491890
146Gait imbalance (HP:0002141)1.86403412
147Protruding tongue (HP:0010808)1.85815424
148Slow saccadic eye movements (HP:0000514)1.85210618
149Atrial fibrillation (HP:0005110)1.85202840
150Primary atrial arrhythmia (HP:0001692)1.84676715
151Abnormality of salivation (HP:0100755)1.83912855
152Truncal obesity (HP:0001956)1.82879561
153Aqueductal stenosis (HP:0002410)1.82050527
154Exercise-induced myalgia (HP:0003738)1.81686902
155Thyroiditis (HP:0100646)1.80661775
156Blue irides (HP:0000635)1.80457891
157Large earlobe (HP:0009748)1.79488451
158Generalized myoclonic seizures (HP:0002123)1.79158763
159Focal dystonia (HP:0004373)1.77771980
160Congenital stationary night blindness (HP:0007642)1.77581506
161Spastic paraplegia (HP:0001258)1.77516947
162Polyphagia (HP:0002591)1.77381402
163Rhabdomyosarcoma (HP:0002859)1.77232996
164Abnormal respiratory motile cilium physiology (HP:0012261)1.74916419
165Dyschromatopsia (HP:0007641)1.74718200
166Pulmonary embolism (HP:0002204)1.72186684
167Prolonged bleeding time (HP:0003010)1.72073894
168Resting tremor (HP:0002322)1.69304888
169Elevated erythrocyte sedimentation rate (HP:0003565)1.67793314
170Colitis (HP:0002583)1.67395284
171Urticaria (HP:0001025)1.67018757
172Inflammation of the large intestine (HP:0002037)1.64981709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.32002348
2MAP3K93.66568186
3EPHA43.48573477
4MAP3K43.27771848
5MARK13.18387048
6MAP2K72.68833094
7MINK12.56882702
8PAK62.22588443
9BLK2.21633133
10KSR22.12884802
11PRKD32.09118228
12MAP2K42.08724680
13NTRK21.95315025
14DAPK21.94355996
15FGR1.92882406
16RIPK41.89500704
17NTRK11.79231752
18YES11.70692041
19CAMKK11.69848237
20PNCK1.65713924
21CSK1.62925953
22MAP3K121.61730667
23TEC1.57877288
24MAP2K31.55894520
25BCR1.54808901
26KSR11.53046824
27PHKG21.52705176
28PHKG11.52705176
29STK381.51041333
30ERBB31.50292640
31CASK1.47343726
32CDK51.43809632
33BTK1.43708512
34MAPK131.40935208
35IRAK41.37007381
36CAMKK21.35234508
37BRD41.33619371
38SYK1.31151586
39PLK21.30892729
40TNIK1.23925332
41GRK51.22776870
42JAK21.22270736
43PDK41.20562551
44PDK31.20562551
45GRK61.19139456
46MAP3K21.19084533
47IRAK21.17484466
48HCK1.17030806
49SIK21.16595490
50EPHA31.15954582
51PINK11.12443157
52TYK21.11813224
53DYRK31.10706100
54DAPK11.09874565
55DYRK1B1.07648928
56PRKCG1.07488674
57MAP3K101.07276799
58ACVR1B1.06651034
59SIK31.05875024
60CAMK2A1.05869024
61RET1.05252852
62FRK1.05199251
63RPS6KA41.05132627
64LMTK21.04987705
65SGK2231.04092248
66SGK4941.04092248
67LATS21.03415257
68ARAF1.03233130
69MAP3K131.01248261
70SGK20.99319335
71MARK30.99014477
72WNK10.97301902
73CAMK1G0.96417962
74PRPF4B0.96238028
75SRPK10.93637791
76MAP3K60.91516824
77FES0.91109308
78TAOK10.90627837
79LYN0.90050518
80ZAP700.90016379
81ITK0.89658544
82IRAK10.87406752
83PAK30.86930469
84PTK2B0.86795287
85CAMK10.86670660
86STK110.86563123
87UHMK10.86107801
88MAP4K10.85208003
89SGK30.84281010
90MAP3K50.83603622
91PRKCH0.82973216
92TXK0.82446801
93TRIM280.81485712
94RIPK10.81357541
95CDK190.80921408
96TYRO30.79848548
97CDK60.79205367
98RAF10.79072828
99SGK10.78251900
100PDK10.76531570
101IKBKE0.74612029
102CAMK1D0.74546988
103LCK0.74440105
104DMPK0.73780129
105CDK180.72240306
106BMPR20.70982712
107CDK150.70454606
108CAMK2B0.70037500
109PIM10.69633908
110MARK20.69461127
111PIK3CG0.69144790
112CSNK1G20.68867941
113CDK140.68180298
114JAK10.68121255
115PDPK10.67021568
116CSF1R0.64782141
117MAP3K10.64499229
118CAMK2D0.64441051
119DYRK1A0.64130352
120OBSCN0.63923490
121MUSK0.62389167
122MKNK10.61516455
123TAOK30.61501147
124STK390.60909550
125OXSR10.60562450
126EGFR0.60271125
127ERBB20.58505195
128CDK11A0.57623185
129STK40.56905717
130MKNK20.56815707
131TNK20.56374744
132JAK30.56206700
133PRKCE0.55702928
134WNK40.55427597
135STK38L0.55143863
136MAP3K140.54500885
137PDK20.51742719
138RPS6KA30.50962648
139CDC42BPA0.48638610
140PRKCZ0.46851258
141CCNB10.46252284
142MAPK100.44580353
143ICK0.42664034
144CAMK40.41060521
145CAMK2G0.40976324
146MAPK120.39925183
147ALK0.39092672
148PKN10.38657169
149FYN0.38457605
150FER0.37879122
151WNK30.36699377
152FGFR20.36016211
153PRKAA10.34840095
154RPS6KA20.34443489

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.34603144
2Synaptic vesicle cycle_Homo sapiens_hsa047212.93191701
3Olfactory transduction_Homo sapiens_hsa047402.60164449
4Circadian entrainment_Homo sapiens_hsa047132.59169885
5Long-term potentiation_Homo sapiens_hsa047202.59117691
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53771651
7Glutamatergic synapse_Homo sapiens_hsa047242.48678972
8GABAergic synapse_Homo sapiens_hsa047272.44132502
9Morphine addiction_Homo sapiens_hsa050322.33904825
10Amphetamine addiction_Homo sapiens_hsa050312.25176532
11Dopaminergic synapse_Homo sapiens_hsa047282.12573753
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11212382
13Salivary secretion_Homo sapiens_hsa049702.05002070
14Insulin secretion_Homo sapiens_hsa049112.03440842
15Osteoclast differentiation_Homo sapiens_hsa043801.96568831
16Leishmaniasis_Homo sapiens_hsa051401.95055658
17Cholinergic synapse_Homo sapiens_hsa047251.92987755
18B cell receptor signaling pathway_Homo sapiens_hsa046621.88290485
19Taste transduction_Homo sapiens_hsa047421.82309555
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.81769243
21Gastric acid secretion_Homo sapiens_hsa049711.77978488
22Phototransduction_Homo sapiens_hsa047441.76375048
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75686541
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74812492
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74517594
26Renin secretion_Homo sapiens_hsa049241.73372061
27Serotonergic synapse_Homo sapiens_hsa047261.67021099
28Oxytocin signaling pathway_Homo sapiens_hsa049211.63974833
29Long-term depression_Homo sapiens_hsa047301.63671961
30Calcium signaling pathway_Homo sapiens_hsa040201.59550248
31Tuberculosis_Homo sapiens_hsa051521.58678230
32T cell receptor signaling pathway_Homo sapiens_hsa046601.55960699
33Cocaine addiction_Homo sapiens_hsa050301.45634429
34GnRH signaling pathway_Homo sapiens_hsa049121.45306761
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44295995
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41680977
37Legionellosis_Homo sapiens_hsa051341.39796437
38Type II diabetes mellitus_Homo sapiens_hsa049301.37340505
39Non-homologous end-joining_Homo sapiens_hsa034501.33458432
40cAMP signaling pathway_Homo sapiens_hsa040241.31086775
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30907268
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30565654
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29010737
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26923695
45Gap junction_Homo sapiens_hsa045401.25832832
46Cardiac muscle contraction_Homo sapiens_hsa042601.23717978
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19682778
48Estrogen signaling pathway_Homo sapiens_hsa049151.19237829
49Collecting duct acid secretion_Homo sapiens_hsa049661.16194579
50Acute myeloid leukemia_Homo sapiens_hsa052211.14508669
51Dorso-ventral axis formation_Homo sapiens_hsa043201.11911003
52FoxO signaling pathway_Homo sapiens_hsa040681.11158966
53Glioma_Homo sapiens_hsa052141.09866609
54Pancreatic cancer_Homo sapiens_hsa052121.07507020
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07403214
56Pancreatic secretion_Homo sapiens_hsa049721.06605349
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04485177
58Measles_Homo sapiens_hsa051621.03703378
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03123084
60Dilated cardiomyopathy_Homo sapiens_hsa054141.02891541
61Hepatitis B_Homo sapiens_hsa051611.01990340
62Staphylococcus aureus infection_Homo sapiens_hsa051501.00646900
63Axon guidance_Homo sapiens_hsa043601.00608386
64ErbB signaling pathway_Homo sapiens_hsa040121.00551208
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00515231
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.99367948
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94530421
68Oocyte meiosis_Homo sapiens_hsa041140.93379086
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92077037
70Influenza A_Homo sapiens_hsa051640.91495695
71Chronic myeloid leukemia_Homo sapiens_hsa052200.91214840
72Phagosome_Homo sapiens_hsa041450.91205689
73Systemic lupus erythematosus_Homo sapiens_hsa053220.91111426
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.90711533
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89089065
76Melanogenesis_Homo sapiens_hsa049160.88738119
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.87320092
78Salmonella infection_Homo sapiens_hsa051320.86187884
79Viral myocarditis_Homo sapiens_hsa054160.84478717
80Graft-versus-host disease_Homo sapiens_hsa053320.83833123
81Toxoplasmosis_Homo sapiens_hsa051450.82808021
82Viral carcinogenesis_Homo sapiens_hsa052030.81207302
83Choline metabolism in cancer_Homo sapiens_hsa052310.81191470
84Regulation of autophagy_Homo sapiens_hsa041400.79451252
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.79258540
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78562929
87Glucagon signaling pathway_Homo sapiens_hsa049220.78325260
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76097513
89VEGF signaling pathway_Homo sapiens_hsa043700.76021312
90MAPK signaling pathway_Homo sapiens_hsa040100.75669867
91HIF-1 signaling pathway_Homo sapiens_hsa040660.74521770
92Thyroid hormone synthesis_Homo sapiens_hsa049180.73712302
93Shigellosis_Homo sapiens_hsa051310.71914700
94Circadian rhythm_Homo sapiens_hsa047100.70244525
95Malaria_Homo sapiens_hsa051440.70083959
96Hematopoietic cell lineage_Homo sapiens_hsa046400.69799906
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68350024
98Inositol phosphate metabolism_Homo sapiens_hsa005620.68336532
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.66961394
100Herpes simplex infection_Homo sapiens_hsa051680.66492317
101mTOR signaling pathway_Homo sapiens_hsa041500.66324813
102Vibrio cholerae infection_Homo sapiens_hsa051100.65874271
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65709345
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65641118
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64236178
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63294056
107Allograft rejection_Homo sapiens_hsa053300.62653239
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61754834
109Ras signaling pathway_Homo sapiens_hsa040140.61727559
110Prostate cancer_Homo sapiens_hsa052150.61693820
111Apoptosis_Homo sapiens_hsa042100.61057420
112Primary immunodeficiency_Homo sapiens_hsa053400.60115046
113Autoimmune thyroid disease_Homo sapiens_hsa053200.59282283
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.58161549
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57673239
116Endometrial cancer_Homo sapiens_hsa052130.56838792
117Insulin signaling pathway_Homo sapiens_hsa049100.55411793
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54788692
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54223239
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52225548
121Rap1 signaling pathway_Homo sapiens_hsa040150.51336729
122Renal cell carcinoma_Homo sapiens_hsa052110.50214466
123Ovarian steroidogenesis_Homo sapiens_hsa049130.49352796
124Alcoholism_Homo sapiens_hsa050340.48058311
125Endocytosis_Homo sapiens_hsa041440.47488158
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44706006
127Non-small cell lung cancer_Homo sapiens_hsa052230.44300875
128Type I diabetes mellitus_Homo sapiens_hsa049400.42102566
129Alzheimers disease_Homo sapiens_hsa050100.40526843
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39242712
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39115313
132Wnt signaling pathway_Homo sapiens_hsa043100.36752609
133Prolactin signaling pathway_Homo sapiens_hsa049170.35691697
134Chemokine signaling pathway_Homo sapiens_hsa040620.34875568
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32903231
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.30328850
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.30133064
138Colorectal cancer_Homo sapiens_hsa052100.29705060
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28177859
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27288587
141Bile secretion_Homo sapiens_hsa049760.27151541
142Platelet activation_Homo sapiens_hsa046110.25530545
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25202525
144AMPK signaling pathway_Homo sapiens_hsa041520.25031395

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