AGTR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle contraction (GO:0003009)7.00063425
2muscle filament sliding (GO:0030049)6.81574993
3actin-myosin filament sliding (GO:0033275)6.81574993
4bone trabecula formation (GO:0060346)6.60705066
5protein heterotrimerization (GO:0070208)6.53474348
6collagen fibril organization (GO:0030199)6.30184407
7chondrocyte proliferation (GO:0035988)5.80375273
8actin-mediated cell contraction (GO:0070252)5.79045416
9response to pheromone (GO:0019236)5.78340554
10parturition (GO:0007567)5.58235435
11planar cell polarity pathway involved in neural tube closure (GO:0090179)5.53012796
12short-term memory (GO:0007614)5.49283251
13regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)5.40550569
14head development (GO:0060322)5.34439654
15regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.29193662
16chondrocyte development (GO:0002063)5.25397307
17regulation of skeletal muscle contraction (GO:0014819)5.13378875
18axon extension involved in axon guidance (GO:0048846)5.08859494
19neuron projection extension involved in neuron projection guidance (GO:1902284)5.08859494
20outer ear morphogenesis (GO:0042473)5.04966351
21sequestering of extracellular ligand from receptor (GO:0035581)5.02921232
22negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.96145546
23metanephric tubule development (GO:0072170)4.81338074
24metanephric nephron tubule development (GO:0072234)4.81338074
25cell proliferation involved in metanephros development (GO:0072203)4.75500005
26multicellular organismal movement (GO:0050879)4.74865644
27musculoskeletal movement (GO:0050881)4.74865644
28peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.72357805
29sarcoplasmic reticulum calcium ion transport (GO:0070296)4.67229212
30regulation of non-canonical Wnt signaling pathway (GO:2000050)4.63344932
31surfactant homeostasis (GO:0043129)4.60647981
32actin filament-based movement (GO:0030048)4.59537305
33negative regulation of chondrocyte differentiation (GO:0032331)4.58909458
34embryonic skeletal joint morphogenesis (GO:0060272)4.53459452
35positive regulation of muscle hypertrophy (GO:0014742)4.52161752
36positive regulation of cardiac muscle hypertrophy (GO:0010613)4.52161752
37embryonic cranial skeleton morphogenesis (GO:0048701)4.47528965
38metanephric mesenchyme development (GO:0072075)4.46279850
39metanephric nephron epithelium development (GO:0072243)4.45616415
40myofibril assembly (GO:0030239)4.45602567
41striated muscle contraction (GO:0006941)4.41541719
42cerebellar granule cell differentiation (GO:0021707)4.38872963
43negative regulation of potassium ion transmembrane transport (GO:1901380)4.37708791
44cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.35599386
45craniofacial suture morphogenesis (GO:0097094)4.34241304
46collagen catabolic process (GO:0030574)4.33965035
47collagen metabolic process (GO:0032963)4.31728806
48metanephric epithelium development (GO:0072207)4.30773480
49glomerular filtration (GO:0003094)4.25135276
50cell proliferation involved in kidney development (GO:0072111)4.20843716
51kidney mesenchyme development (GO:0072074)4.20748300
52middle ear morphogenesis (GO:0042474)4.16241407
53negative regulation of axon extension involved in axon guidance (GO:0048843)4.16182219
54sarcomere organization (GO:0045214)4.08091143
55Wnt signaling pathway, planar cell polarity pathway (GO:0060071)4.04413095
56positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.03974373
57multicellular organismal macromolecule metabolic process (GO:0044259)4.02960777
58cerebellar Purkinje cell differentiation (GO:0021702)4.01970947
59regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.98644586
60regulation of establishment of planar polarity (GO:0090175)3.96375348
61multicellular organismal catabolic process (GO:0044243)3.95924696
62regulation of cardiac muscle hypertrophy (GO:0010611)3.95378783
63regulation of muscle hypertrophy (GO:0014743)3.94085086
64endodermal cell differentiation (GO:0035987)3.93838263
65negative regulation of cartilage development (GO:0061037)3.92921980
66cell migration involved in heart development (GO:0060973)3.92918975
67cardiac myofibril assembly (GO:0055003)3.92626440
68mesenchyme morphogenesis (GO:0072132)3.91348300
69midgut development (GO:0007494)3.85475008
70regulation of skeletal muscle cell differentiation (GO:2001014)3.85422191
71regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.82819519
72mesenchymal-epithelial cell signaling (GO:0060638)3.81655180
73cellular response to antibiotic (GO:0071236)3.80826475
74chemical homeostasis within a tissue (GO:0048875)3.80307006
75multicellular organismal metabolic process (GO:0044236)3.80007644
76extracellular fibril organization (GO:0043206)3.79603187
77glomerular visceral epithelial cell development (GO:0072015)3.79564098
78convergent extension (GO:0060026)3.78931367
79muscle cell fate commitment (GO:0042693)3.76924805
80body morphogenesis (GO:0010171)3.73994781
81renal filtration (GO:0097205)3.71037639
82hippo signaling (GO:0035329)3.70879708
83mesenchymal cell proliferation (GO:0010463)3.68114751
84eyelid development in camera-type eye (GO:0061029)3.67457435
85embryonic forelimb morphogenesis (GO:0035115)3.67068570
86negative regulation of catenin import into nucleus (GO:0035414)3.65709578
87insulin-like growth factor receptor signaling pathway (GO:0048009)3.63850985
88lateral sprouting from an epithelium (GO:0060601)3.62483835
89collecting duct development (GO:0072044)3.61982133
90regulation of potassium ion transmembrane transporter activity (GO:1901016)3.61894610
91regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.57752221
92myotube cell development (GO:0014904)3.57556388
93anatomical structure regression (GO:0060033)3.57361837
94extracellular matrix disassembly (GO:0022617)3.57276332
95cochlea morphogenesis (GO:0090103)3.57265749
96positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.55106393
97positive regulation of mesenchymal cell proliferation (GO:0002053)3.54924951
98glucocorticoid metabolic process (GO:0008211)3.53910559
99actomyosin structure organization (GO:0031032)3.52440776
100neural crest cell development (GO:0014032)3.51330707
101skeletal muscle fiber development (GO:0048741)3.50913594
102negative regulation of axon guidance (GO:1902668)3.50674451
103regulation of cell communication by electrical coupling (GO:0010649)3.48562972
104positive regulation of gastrulation (GO:2000543)3.48333928
105regulation of muscle adaptation (GO:0043502)3.47260246
106regulation of mesenchymal cell proliferation (GO:0010464)3.45035927
107positive regulation of smoothened signaling pathway (GO:0045880)3.44483287
108regulation of heart morphogenesis (GO:2000826)3.43310878
109positive regulation of catenin import into nucleus (GO:0035413)3.41986830
110endocardial cushion morphogenesis (GO:0003203)3.41968447
111negative regulation of cell fate specification (GO:0009996)3.40389675
112non-canonical Wnt signaling pathway (GO:0035567)3.38198169
113glomerular epithelial cell development (GO:0072310)3.34299387
114mesenchymal cell development (GO:0014031)3.32801611
115cranial suture morphogenesis (GO:0060363)3.32726728
116keratan sulfate catabolic process (GO:0042340)3.32439095
117embryonic skeletal system development (GO:0048706)3.31606405
118skin morphogenesis (GO:0043589)3.31339504
119nephron tubule development (GO:0072080)3.31284758
120regulation of catenin import into nucleus (GO:0035412)3.30480748
121negative regulation of embryonic development (GO:0045992)3.30030212
122regulation of gastrulation (GO:0010470)3.28456472
123negative regulation of DNA repair (GO:0045738)3.28267797
124fibril organization (GO:0097435)3.28089758
125palate development (GO:0060021)3.26499315
126regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.24560125
127negative chemotaxis (GO:0050919)3.24141905
128retina layer formation (GO:0010842)3.23448845
129positive regulation of fatty acid beta-oxidation (GO:0032000)3.23045536
130regulation of cartilage development (GO:0061035)3.22576890
131regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.22081845
132forelimb morphogenesis (GO:0035136)3.21475751
133glial cell migration (GO:0008347)3.21395567
134embryonic hindlimb morphogenesis (GO:0035116)3.19838911
135positive regulation of myotube differentiation (GO:0010831)3.18017369
136paraxial mesoderm development (GO:0048339)3.16817849
137positive regulation of epithelial to mesenchymal transition (GO:0010718)3.16542532
138hindlimb morphogenesis (GO:0035137)3.14961925
139mesenchyme development (GO:0060485)3.14744065
140inositol phosphate-mediated signaling (GO:0048016)3.14593718
141positive regulation of myoblast differentiation (GO:0045663)3.12384015
142positive regulation of glycogen biosynthetic process (GO:0045725)3.11583756
143regulation of chondrocyte differentiation (GO:0032330)3.10100080
144peptidyl-proline hydroxylation (GO:0019511)3.10038410
145cell differentiation in hindbrain (GO:0021533)3.09443348
146dermatan sulfate biosynthetic process (GO:0030208)3.09268004
147regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.09026845
148embryonic skeletal system morphogenesis (GO:0048704)3.08467882
149relaxation of smooth muscle (GO:0044557)3.07270006
150embryonic digit morphogenesis (GO:0042733)3.07085674
151regulation of cell fate specification (GO:0042659)3.06755598
152regulation of potassium ion transmembrane transport (GO:1901379)3.06512969
153regulation of axon extension involved in axon guidance (GO:0048841)3.03848713
154response to inactivity (GO:0014854)3.03556674
155cardiac muscle contraction (GO:0060048)3.03257790
156embryonic limb morphogenesis (GO:0030326)3.03086494
157embryonic appendage morphogenesis (GO:0035113)3.03086494
158regulation of relaxation of muscle (GO:1901077)2.99814505
159plasma membrane repair (GO:0001778)2.98140862
160nephron epithelium development (GO:0072009)2.97184113
161bone morphogenesis (GO:0060349)2.95992892
162regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94005780
163glucocorticoid biosynthetic process (GO:0006704)2.90811124
164renal tubule development (GO:0061326)2.90420173
165protein heterotetramerization (GO:0051290)2.90009027
166regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.89973241
167cerebellar Purkinje cell layer development (GO:0021680)2.88154361
168relaxation of muscle (GO:0090075)2.88058680
169aggressive behavior (GO:0002118)2.86594845
170cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.86236855
171fructose metabolic process (GO:0006000)2.85685784
172muscle fiber development (GO:0048747)2.84850188
173gamma-aminobutyric acid signaling pathway (GO:0007214)2.84223253
174skeletal muscle tissue development (GO:0007519)2.83975182
175regulation of cardiac muscle cell differentiation (GO:2000725)2.82966633
176positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.81321932
177glomerular basement membrane development (GO:0032836)2.80854021
178muscle contraction (GO:0006936)2.80683880
179lung-associated mesenchyme development (GO:0060484)2.73988848
180relaxation of cardiac muscle (GO:0055119)2.72745115
181regulation of sarcomere organization (GO:0060297)2.72034742
182muscle organ development (GO:0007517)2.69437812
183response to caffeine (GO:0031000)2.67133898
184nucleus localization (GO:0051647)2.63737337
185prepulse inhibition (GO:0060134)2.63682548
186muscle structure development (GO:0061061)2.63667640
187negative regulation of protein localization to cell surface (GO:2000009)2.63613095
188neuromuscular junction development (GO:0007528)2.63223779
189Leydig cell differentiation (GO:0033327)2.62916529
190response to follicle-stimulating hormone (GO:0032354)2.61731591
191muscle system process (GO:0003012)2.59992559
192heart morphogenesis (GO:0003007)2.59918864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.12218645
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.59504717
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.57670784
4WT1_19549856_ChIP-ChIP_CCG9911_Human3.47084190
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.41499830
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.38933989
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.19427944
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03099654
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.91291423
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.83556884
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.73818514
12CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.69638700
13* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.67192542
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.66608956
15TAF15_26573619_Chip-Seq_HEK293_Human2.51545666
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50780808
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50780808
18WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.40543532
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.39083383
20* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.37560729
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34520362
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.29865968
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22812900
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.18543931
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17671381
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.13086304
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12265690
28TP53_20018659_ChIP-ChIP_R1E_Mouse2.10606274
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09646931
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06456668
31JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03716882
32POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01283277
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95249825
34TP53_18474530_ChIP-ChIP_U2OS_Human1.95046603
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88364763
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.86387436
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83944799
38BRD4_25478319_ChIP-Seq_HGPS_Human1.83042737
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.82680952
40* CJUN_26792858_Chip-Seq_BT549_Human1.78587563
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.77203180
42AR_21572438_ChIP-Seq_LNCaP_Human1.76885714
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76571843
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.74656032
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73763578
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.72288816
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72130641
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.70631780
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68999607
50VDR_22108803_ChIP-Seq_LS180_Human1.67030648
51CLOCK_20551151_ChIP-Seq_293T_Human1.64773723
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64572466
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64374768
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64085487
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.62834642
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59562464
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53967725
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53967725
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53066992
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52309150
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50558209
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49798114
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.49285210
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.47787479
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44214198
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41884296
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39715381
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39642309
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39438587
70TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.36123058
71FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.35288753
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34923100
73LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34286968
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34201857
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33305114
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32151624
77TP53_16413492_ChIP-PET_HCT116_Human1.31530776
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30923724
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.30664479
80SA1_22415368_ChIP-Seq_MEFs_Mouse1.29121841
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.28711067
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26249569
83P300_19829295_ChIP-Seq_ESCs_Human1.26243722
84EZH2_22144423_ChIP-Seq_EOC_Human1.24979251
85SMAD3_21741376_ChIP-Seq_HESCs_Human1.24830586
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24136971
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23554419
88* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18744878
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17333247
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17314653
91AR_25329375_ChIP-Seq_VCAP_Human1.16684883
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16447236
93* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15688333
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.14876763
95BCAT_22108803_ChIP-Seq_LS180_Human1.14147315
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.13856989
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13695074
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12273127
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11679231
100FUS_26573619_Chip-Seq_HEK293_Human1.10830844
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.10384473
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.09696310
103TCF4_18268006_ChIP-ChIP_LS174T_Human1.09460558
104EZH2_27294783_Chip-Seq_ESCs_Mouse1.09198313
105ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08967424
106GBX2_23144817_ChIP-Seq_PC3_Human1.08257441
107KDM2B_26808549_Chip-Seq_REH_Human1.07773665
108SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07368120
109NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07242410
110RXR_22108803_ChIP-Seq_LS180_Human1.07092382
111EWS_26573619_Chip-Seq_HEK293_Human1.07073788
112TBX20_22328084_ChIP-Seq_HEART_Mouse1.06553508
113TBX20_22080862_ChIP-Seq_HEART_Mouse1.06553508
114* SMAD4_21741376_ChIP-Seq_HESCs_Human1.06408320
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.05048866
116TCF4_23295773_ChIP-Seq_U87_Human1.04215900
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03579451
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03349493
119AR_21909140_ChIP-Seq_LNCAP_Human1.02242263
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00725057
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00243929
122CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00233814
123STAT3_23295773_ChIP-Seq_U87_Human0.99854399
124SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99684769
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99416019
126TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98939060
127TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98758151
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98284893
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97827013
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.97480453
131SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96941086
132TAL1_26923725_Chip-Seq_HPCs_Mouse0.96229734
133YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92524081
134SMAD3_21741376_ChIP-Seq_EPCs_Human0.92391351
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92343227
136SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92263112
137SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90137766
138SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89727271
139P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89331272
140FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89201055
141AR_19668381_ChIP-Seq_PC3_Human0.88629094
142UBF1/2_26484160_Chip-Seq_HMECs_Human0.87763008
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87258928

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.06931238
2MP0005503_abnormal_tendon_morphology5.43623479
3MP0003122_maternal_imprinting5.31231963
4MP0005275_abnormal_skin_tensile4.05308790
5MP0000749_muscle_degeneration3.19594298
6MP0000013_abnormal_adipose_tissue3.15018778
7MP0003385_abnormal_body_wall3.11181707
8MP0003123_paternal_imprinting2.87573525
9MP0010030_abnormal_orbit_morphology2.86991307
10MP0009250_abnormal_appendicular_skeleto2.85721681
11MP0004272_abnormal_basement_membrane2.72816932
12MP0003121_genomic_imprinting2.72359700
13MP0004084_abnormal_cardiac_muscle2.48636908
14MP0004036_abnormal_muscle_relaxation2.45813701
15MP0003705_abnormal_hypodermis_morpholog2.44207649
16MP0009053_abnormal_anal_canal2.38089965
17MP0009384_cardiac_valve_regurgitation2.27143557
18* MP0003942_abnormal_urinary_system2.21588647
19MP0005508_abnormal_skeleton_morphology2.15349001
20MP0000750_abnormal_muscle_regeneration2.14316562
21MP0006054_spinal_hemorrhage2.09730757
22MP0009046_muscle_twitch2.09618311
23MP0010386_abnormal_urinary_bladder2.09127771
24MP0000049_abnormal_middle_ear2.08402990
25MP0003950_abnormal_plasma_membrane2.06187521
26MP0004782_abnormal_surfactant_physiolog2.02526168
27MP0005623_abnormal_meninges_morphology2.01666187
28MP0004270_analgesia1.96470197
29MP0001958_emphysema1.96050601
30* MP0005620_abnormal_muscle_contractility1.95660673
31MP0002282_abnormal_trachea_morphology1.95260281
32MP0002249_abnormal_larynx_morphology1.94951519
33MP0003279_aneurysm1.90674726
34MP0002932_abnormal_joint_morphology1.90384751
35MP0003755_abnormal_palate_morphology1.88112869
36* MP0000534_abnormal_ureter_morphology1.85556368
37MP0000733_abnormal_muscle_development1.81718470
38MP0002938_white_spotting1.81114241
39* MP0004087_abnormal_muscle_fiber1.80518937
40MP0004742_abnormal_vestibular_system1.79925124
41MP0000428_abnormal_craniofacial_morphol1.78814722
42MP0003937_abnormal_limbs/digits/tail_de1.78485595
43MP0004215_abnormal_myocardial_fiber1.74091282
44MP0002106_abnormal_muscle_physiology1.73427730
45MP0002108_abnormal_muscle_morphology1.72670183
46MP0002115_abnormal_skeleton_extremities1.72246348
47MP0000762_abnormal_tongue_morphology1.69071193
48MP0002896_abnormal_bone_mineralization1.67254247
49MP0005369_muscle_phenotype1.66462498
50MP0001299_abnormal_eye_distance/1.66402009
51MP0002109_abnormal_limb_morphology1.65554678
52MP0003935_abnormal_craniofacial_develop1.60524396
53MP0000163_abnormal_cartilage_morphology1.58813049
54MP0004134_abnormal_chest_morphology1.58576345
55MP0003941_abnormal_skin_development1.54043721
56MP0002269_muscular_atrophy1.48725316
57MP0000747_muscle_weakness1.46941921
58MP0002113_abnormal_skeleton_development1.44932651
59MP0002233_abnormal_nose_morphology1.42398446
60MP0002116_abnormal_craniofacial_bone1.42081527
61MP0003115_abnormal_respiratory_system1.41441154
62MP0001879_abnormal_lymphatic_vessel1.35983905
63MP0005257_abnormal_intraocular_pressure1.35891402
64MP0000003_abnormal_adipose_tissue1.34423685
65MP0001270_distended_abdomen1.33258890
66MP0000537_abnormal_urethra_morphology1.32352441
67MP0000432_abnormal_head_morphology1.30657926
68MP0002060_abnormal_skin_morphology1.27198689
69MP0001984_abnormal_olfaction1.26978694
70MP0008004_abnormal_stomach_pH1.26925555
71MP0008569_lethality_at_weaning1.26653048
72MP0003137_abnormal_impulse_conducting1.25025539
73MP0005367_renal/urinary_system_phenotyp1.24516587
74MP0000516_abnormal_urinary_system1.24516587
75MP0002272_abnormal_nervous_system1.23005454
76MP0005388_respiratory_system_phenotype1.21676721
77MP0002133_abnormal_respiratory_system1.21676721
78MP0002114_abnormal_axial_skeleton1.21352438
79* MP0004484_altered_response_of1.20171949
80MP0003879_abnormal_hair_cell1.15079832
81MP0001440_abnormal_grooming_behavior1.14912004
82MP0002972_abnormal_cardiac_muscle1.13775190
83MP0010234_abnormal_vibrissa_follicle1.13647860
84MP0004197_abnormal_fetal_growth/weight/1.12630035
85MP0001243_abnormal_dermal_layer1.12334975
86MP0002638_abnormal_pupillary_reflex1.11712044
87MP0002111_abnormal_tail_morphology1.10976021
88MP0003045_fibrosis1.06615013
89MP0001661_extended_life_span1.05929604
90MP0001340_abnormal_eyelid_morphology1.02834908
91MP0005330_cardiomyopathy1.01934687
92MP0005248_abnormal_Harderian_gland0.99701966
93MP0004145_abnormal_muscle_electrophysio0.99406636
94MP0009703_decreased_birth_body0.99217266
95MP0005390_skeleton_phenotype0.97156210
96MP0001293_anophthalmia0.96200815
97MP0005076_abnormal_cell_differentiation0.94612456
98MP0000613_abnormal_salivary_gland0.94496940
99MP0002933_joint_inflammation0.94305139
100MP0002177_abnormal_outer_ear0.93462138
101MP0000566_synostosis0.93325925
102MP0004233_abnormal_muscle_weight0.92823200
103* MP0010630_abnormal_cardiac_muscle0.92215913
104MP0002163_abnormal_gland_morphology0.91106511
105MP0002332_abnormal_exercise_endurance0.87116810
106MP0003283_abnormal_digestive_organ0.86933333
107MP0009780_abnormal_chondrocyte_physiolo0.86214301
108MP0005023_abnormal_wound_healing0.86064094
109MP0002089_abnormal_postnatal_growth/wei0.85319259
110MP0000751_myopathy0.84689732
111MP0003567_abnormal_fetal_cardiomyocyte0.84530941
112* MP0000767_abnormal_smooth_muscle0.83918923
113MP0002184_abnormal_innervation0.83053069
114MP0005171_absent_coat_pigmentation0.83043519
115MP0001175_abnormal_lung_morphology0.83005038
116MP0003566_abnormal_cell_adhesion0.82813097
117MP0001286_abnormal_eye_development0.82685289
118MP0002295_abnormal_pulmonary_circulatio0.81650614
119MP0000462_abnormal_digestive_system0.80514213
120MP0010368_abnormal_lymphatic_system0.80310554
121MP0003938_abnormal_ear_development0.80044906
122MP0001542_abnormal_bone_strength0.78099123
123MP0009672_abnormal_birth_weight0.77989101
124* MP0005595_abnormal_vascular_smooth0.76784668
125MP0003091_abnormal_cell_migration0.76251779
126MP0002067_abnormal_sensory_capabilities0.76122334
127MP0008995_early_reproductive_senescence0.76065354
128MP0001544_abnormal_cardiovascular_syste0.75565561
129MP0005385_cardiovascular_system_phenoty0.75565561
130MP0006035_abnormal_mitochondrial_morpho0.75539819
131MP0004043_abnormal_pH_regulation0.73119180
132MP0003635_abnormal_synaptic_transmissio0.72730351
133* MP0004085_abnormal_heartbeat0.71412359
134MP0002092_abnormal_eye_morphology0.70795177
135MP0003119_abnormal_digestive_system0.70455810
136MP0000759_abnormal_skeletal_muscle0.69981626
137MP0006138_congestive_heart_failure0.69835076
138MP0005083_abnormal_biliary_tract0.67973355
139MP0002168_other_aberrant_phenotype0.67500577
140MP0001346_abnormal_lacrimal_gland0.67259184
141MP0001943_abnormal_respiration0.67154016
142* MP0003795_abnormal_bone_structure0.66850620
143MP0002837_dystrophic_cardiac_calcinosis0.66427127
144MP0005187_abnormal_penis_morphology0.65761301
145* MP0002925_abnormal_cardiovascular_devel0.64907651
146MP0002081_perinatal_lethality0.63597936
147MP0000639_abnormal_adrenal_gland0.63597103
148MP0008775_abnormal_heart_ventricle0.62061069
149MP0000678_abnormal_parathyroid_gland0.62051513
150MP0005167_abnormal_blood-brain_barrier0.61945473
151* MP0002128_abnormal_blood_circulation0.61169361
152MP0004883_abnormal_blood_vessel0.61089005
153MP0005197_abnormal_uvea_morphology0.60956378
154* MP0001614_abnormal_blood_vessel0.60455496
155MP0001177_atelectasis0.59314210
156MP0002697_abnormal_eye_size0.58129970
157MP0002138_abnormal_hepatobiliary_system0.56515511
158MP0010678_abnormal_skin_adnexa0.54834507
159* MP0003948_abnormal_gas_homeostasis0.53226532
160MP0002127_abnormal_cardiovascular_syste0.53059503

Predicted human phenotypes

RankGene SetZ-score
1Round ear (HP:0100830)7.61989500
2Calcaneovalgus deformity (HP:0001848)6.90207293
3Ulnar deviation of the wrist (HP:0003049)6.80536799
4Protrusio acetabuli (HP:0003179)6.11885293
5Deformed tarsal bones (HP:0008119)6.08615334
6Trismus (HP:0000211)5.67025933
7Premature rupture of membranes (HP:0001788)5.22237219
8Neoplasm of the heart (HP:0100544)5.15405594
9Absent phalangeal crease (HP:0006109)4.74135704
10Ankle contracture (HP:0006466)4.50821948
11Shallow orbits (HP:0000586)4.47046903
12Metatarsus adductus (HP:0001840)4.41646105
13Fetal akinesia sequence (HP:0001989)4.36228037
14Type 1 muscle fiber predominance (HP:0003803)4.30288919
15Abnormality of the calcaneus (HP:0008364)4.29891146
16Follicular hyperkeratosis (HP:0007502)4.13454774
17Abnormal finger flexion creases (HP:0006143)4.04132788
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.00926098
19Short 4th metacarpal (HP:0010044)4.00926098
20Scanning speech (HP:0002168)3.90548221
21Nemaline bodies (HP:0003798)3.88996532
22Slender build (HP:0001533)3.81030627
23Popliteal pterygium (HP:0009756)3.79876844
24Symphalangism affecting the phalanges of the hand (HP:0009773)3.79573372
25Dysmetric saccades (HP:0000641)3.79058217
26Action tremor (HP:0002345)3.76934795
27Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.65475870
28Soft skin (HP:0000977)3.65147256
29Hepatoblastoma (HP:0002884)3.63565373
30Malignant hyperthermia (HP:0002047)3.63067673
31Aortic dissection (HP:0002647)3.61534312
32Bladder diverticulum (HP:0000015)3.59663490
33Broad metatarsal (HP:0001783)3.55451735
34Atonic seizures (HP:0010819)3.48824698
35Neonatal short-limb short stature (HP:0008921)3.46089899
36Atrophic scars (HP:0001075)3.36710239
37Muscle fiber inclusion bodies (HP:0100299)3.34719703
38Mesomelia (HP:0003027)3.29571195
39Abnormality of dentin (HP:0010299)3.28876570
40Abnormality of the 4th metacarpal (HP:0010012)3.27172453
41Febrile seizures (HP:0002373)3.25756339
42Interstitial pulmonary disease (HP:0006530)3.23028370
43Mitral valve prolapse (HP:0001634)3.20494541
44Renal duplication (HP:0000075)3.05510607
45Dilatation of the ascending aorta (HP:0005111)2.99790294
46Fragile skin (HP:0001030)2.94045842
47Wide anterior fontanel (HP:0000260)2.91097303
48Cervical subluxation (HP:0003308)2.87577300
49Calf muscle hypertrophy (HP:0008981)2.82103825
50Coronal craniosynostosis (HP:0004440)2.81917885
51Peritonitis (HP:0002586)2.80891226
52Exercise-induced myalgia (HP:0003738)2.78846099
53Mildly elevated creatine phosphokinase (HP:0008180)2.76714389
54Chin dimple (HP:0010751)2.76266881
55Spinal rigidity (HP:0003306)2.76133963
56Abnormality of the calf musculature (HP:0001430)2.71916560
57Blue sclerae (HP:0000592)2.69688478
58Aplasia of the musculature (HP:0100854)2.67131250
59Broad toe (HP:0001837)2.65212011
60Asymmetry of the thorax (HP:0001555)2.65150084
61Osteolytic defects of the hand bones (HP:0009699)2.64628804
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.64628804
63Genu recurvatum (HP:0002816)2.64622685
64Wormian bones (HP:0002645)2.62472523
65Deviation of the hallux (HP:0010051)2.61564525
66Aortic aneurysm (HP:0004942)2.59517089
67Microglossia (HP:0000171)2.57643911
68Hypoplastic ischia (HP:0003175)2.54640508
69Cerebral aneurysm (HP:0004944)2.52008085
70Broad long bones (HP:0005622)2.48478830
71Joint laxity (HP:0001388)2.46676748
72Distal arthrogryposis (HP:0005684)2.45353718
73Hallux valgus (HP:0001822)2.44261985
74Ulnar deviation of finger (HP:0009465)2.43699694
75Muscle hypertrophy of the lower extremities (HP:0008968)2.43314717
76Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.43015035
77Muscle fiber splitting (HP:0003555)2.42801082
78Biconcave vertebral bodies (HP:0004586)2.42475308
79Abnormality of the phalanges of the 2nd finger (HP:0009541)2.42019710
80Turricephaly (HP:0000262)2.40251451
81Tubulointerstitial fibrosis (HP:0005576)2.39643948
82Abnormality of the 2nd finger (HP:0004100)2.37802121
83Diastasis recti (HP:0001540)2.34574106
84Limited hip movement (HP:0008800)2.33681091
85Buphthalmos (HP:0000557)2.33525904
86Hip contracture (HP:0003273)2.32376946
87Short middle phalanx of the 5th finger (HP:0004220)2.31773496
88Syringomyelia (HP:0003396)2.31574118
89Spinal cord lesions (HP:0100561)2.31574118
90Dysdiadochokinesis (HP:0002075)2.30786789
91Morphological abnormality of the middle ear (HP:0008609)2.30507303
92Sudden death (HP:0001699)2.30331993
93Bell-shaped thorax (HP:0001591)2.28435911
94Breech presentation (HP:0001623)2.28116823
95Ectopia lentis (HP:0001083)2.23657242
96Abnormal auditory evoked potentials (HP:0006958)2.22815173
97Midline defect of the nose (HP:0004122)2.22250597
98Abnormality of the parietal bone (HP:0002696)2.22113122
99Postural tremor (HP:0002174)2.21476630
100Hyperextensible skin (HP:0000974)2.19091968
101Abnormality of the ischium (HP:0003174)2.18684774
102Broad phalanx (HP:0006009)2.18457689
103Abnormality of the phalanges of the hallux (HP:0010057)2.17978440
104Bowel diverticulosis (HP:0005222)2.17811568
105Broad thumb (HP:0011304)2.15592544
106Short 5th finger (HP:0009237)2.15227226
107Elbow flexion contracture (HP:0002987)2.14432004
108Epiphyseal dysplasia (HP:0002656)2.13734313
109Cutaneous syndactyly (HP:0012725)2.13265883
110Tarsal synostosis (HP:0008368)2.11200348
111Wrist flexion contracture (HP:0001239)2.09389590
112Mitral regurgitation (HP:0001653)2.09258681
113Increased variability in muscle fiber diameter (HP:0003557)2.08997540
114Thoracolumbar scoliosis (HP:0002944)2.08058566
115Osteoarthritis (HP:0002758)2.07762557
116Vertebral compression fractures (HP:0002953)2.06521712
117Lymphangioma (HP:0100764)2.06430721
118Disproportionate tall stature (HP:0001519)2.03651773
119Cutaneous finger syndactyly (HP:0010554)2.02554749
120Synostosis involving bones of the feet (HP:0009140)2.02550113
121Synostosis involving bones of the lower limbs (HP:0009138)2.02550113
122Increased connective tissue (HP:0009025)2.01704396
123Vitreoretinal degeneration (HP:0000655)2.01227512
124Myotonia (HP:0002486)1.98773388
125Broad finger (HP:0001500)1.98594280
126Deep philtrum (HP:0002002)1.98493858
127Abnormal delivery (HP:0001787)1.98148326
128Vascular tortuosity (HP:0004948)1.97877635
129Narrow nasal bridge (HP:0000446)1.96631502
130Abnormal ossification of hand bones (HP:0005921)1.95944682
131Absence seizures (HP:0002121)1.95059623
132Infantile muscular hypotonia (HP:0008947)1.94929784
133Dislocated radial head (HP:0003083)1.94749869
134Horizontal nystagmus (HP:0000666)1.94690670
135Broad phalanges of the hand (HP:0009768)1.94382803
136Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.93950581
137Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.93140926
138Akinesia (HP:0002304)1.93139728
139Hyporeflexia of lower limbs (HP:0002600)1.92560002
140Facial shape deformation (HP:0011334)1.92497053
141Potter facies (HP:0002009)1.92497053
142Abnormality of placental membranes (HP:0011409)1.92133002
143Amniotic constriction ring (HP:0009775)1.92133002
144Abnormality of skeletal muscle fiber size (HP:0012084)1.92024912
145Abnormality of carpal bone ossification (HP:0006257)1.91790235
146Renal salt wasting (HP:0000127)1.91367864
147Hammertoe (HP:0001765)1.90775552
148Broad ribs (HP:0000885)1.90703024
149Striae distensae (HP:0001065)1.90219532
150Protruding ear (HP:0000411)1.88615256
151Mild short stature (HP:0003502)1.88611639
152Knee flexion contracture (HP:0006380)1.88180624
153Inguinal hernia (HP:0000023)1.87182898
154Broad hallux (HP:0010055)1.86132531
155Abnormality of the radial head (HP:0003995)1.86085937
156Enlarged penis (HP:0000040)1.85278933
157Long clavicles (HP:0000890)1.82891355
158Focal motor seizures (HP:0011153)1.82625994
159Thin ribs (HP:0000883)1.81021941
160Gowers sign (HP:0003391)1.80357600
161Difficulty running (HP:0009046)1.79451486
162Neck muscle weakness (HP:0000467)1.78793538
163Adducted thumb (HP:0001181)1.75880833
164Joint contractures involving the joints of the feet (HP:0100492)1.73666060
165Flexion contracture of toe (HP:0005830)1.73666060
166Gaze-evoked nystagmus (HP:0000640)1.72986331
167Thin bony cortex (HP:0002753)1.71853492
168EMG: myopathic abnormalities (HP:0003458)1.68626019
169Exercise-induced muscle cramps (HP:0003710)1.66858477
170Rocker bottom foot (HP:0001838)1.65378546
171Truncal ataxia (HP:0002078)1.61954356
172Bicornuate uterus (HP:0000813)1.60561620
173Aplasia of the phalanges of the hand (HP:0009802)1.59655269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.06884478
2LATS14.41398264
3PDGFRA4.05133259
4MAP3K123.86867976
5EPHA33.81514101
6TIE13.33233046
7SIK13.15374430
8TRIB33.02072590
9MYLK2.72141373
10GRK52.66014937
11LATS22.62542035
12EPHB22.40757551
13TTN2.27035603
14STK32.08876330
15PKN21.92692845
16DMPK1.73369081
17FGFR11.71796689
18ERBB31.67274226
19PAK21.62423601
20CCNB11.53140054
21PTK21.53137310
22MUSK1.49568914
23FER1.49247389
24PTK61.46601460
25NEK91.45167878
26WNK31.44195022
27PDGFRB1.39017512
28PIK3CA1.38111150
29PLK21.37696141
30MOS1.36280189
31RPS6KA41.34849422
32WNK11.32880847
33MAP3K101.31509070
34RIPK11.31160043
35FGFR21.30416469
36NTRK31.25852423
37MET1.24929318
38CDK81.21470076
39MKNK11.21100050
40CAMK1D1.13781068
41TGFBR21.13559680
42PAK41.12975548
43STK38L1.11415559
44PRKG11.10662272
45CAMK1G1.09307479
46MAPK121.08927779
47OBSCN1.05492891
48TGFBR11.02852785
49CSNK1A1L1.02731153
50FRK0.98873541
51PTK2B0.98870779
52MTOR0.98864088
53PAK30.98749051
54NLK0.98524892
55OXSR10.98107397
56BMX0.96345136
57EEF2K0.95925321
58NUAK10.95924541
59NTRK10.93402121
60LRRK20.92979259
61ERN10.92808034
62ROCK10.91665986
63SGK20.91613427
64MARK20.91359307
65MAP3K90.91036294
66CDK120.82237570
67MKNK20.79603614
68MAP3K70.78470791
69PRKG20.76758150
70SCYL20.76158306
71CAMK2A0.76040686
72ERBB20.74951651
73KDR0.73406000
74CDK70.70668613
75TAOK20.68904168
76ILK0.68727286
77FLT30.68415417
78ROCK20.68234787
79PLK30.67424597
80MAPKAPK30.66137938
81EIF2AK20.65688642
82CDK60.64328284
83TTK0.63481069
84PRKCH0.62617794
85LIMK10.61842733
86SGK4940.60056354
87SGK2230.60056354
88PIK3CG0.58341859
89CDK30.57878810
90CAMKK20.57325872
91FGFR40.57190837
92PDK10.56650816
93FGFR30.56252827
94AKT30.54471901
95AKT20.53753421
96SGK30.53163081
97MAPK10.52546851
98ADRBK10.52361905
99RPS6KB20.50557842
100MAPK150.49670649
101CSNK1G10.48897423
102FYN0.48543358
103KSR20.48385657
104RPS6KA30.47346945
105SRC0.46700490
106PRKACA0.45987597
107MAPK70.43673731
108ICK0.43528117
109MAP3K40.43041221
110INSR0.42945348
111MAP3K10.42674029
112DYRK1B0.42579788
113PRKCA0.42550735
114MAPK80.42494349
115STK390.42209545
116JAK10.41714960
117PRKD20.40158370
118PRKDC0.38793468
119RPS6KB10.38474259
120PRKCG0.37909482
121MAP4K20.36123139
122PRKCE0.35663382
123IGF1R0.34610610
124RET0.34064547
125GSK3A0.34041852
126KIT0.33589693
127CDC42BPA0.33326912
128MAP2K10.32787169
129TRPM70.31037784
130SGK10.30917164
131CHUK0.30607584
132CDK140.29908197
133CASK0.29806279
134EPHB10.29156251
135MAPK140.28295396
136AKT10.27639222
137MAP3K30.27492509
138PRKD30.27463878
139PRKD10.26004515
140BRD40.25228767
141CSNK1G30.25052976
142MAPK30.24808599
143KSR10.24672079
144CSNK1G20.23612022
145TYRO30.22980519
146CSNK1D0.22880432
147CSF1R0.21458747
148MAPK100.21148014

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.22570910
2Protein digestion and absorption_Homo sapiens_hsa049743.80102087
3Nitrogen metabolism_Homo sapiens_hsa009103.60973511
4Basal cell carcinoma_Homo sapiens_hsa052173.32543574
5Long-term depression_Homo sapiens_hsa047303.22066969
6Hedgehog signaling pathway_Homo sapiens_hsa043403.14571882
7Focal adhesion_Homo sapiens_hsa045102.85702519
8Proteoglycans in cancer_Homo sapiens_hsa052052.46503690
9Hippo signaling pathway_Homo sapiens_hsa043902.37751846
10Circadian entrainment_Homo sapiens_hsa047132.27402306
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.24589261
12TGF-beta signaling pathway_Homo sapiens_hsa043502.16241914
13Adherens junction_Homo sapiens_hsa045202.10728827
14Gastric acid secretion_Homo sapiens_hsa049712.05674616
15Salivary secretion_Homo sapiens_hsa049702.03983243
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97924666
17MicroRNAs in cancer_Homo sapiens_hsa052061.97673681
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.92938077
19Long-term potentiation_Homo sapiens_hsa047201.92716109
20Wnt signaling pathway_Homo sapiens_hsa043101.90802851
21Axon guidance_Homo sapiens_hsa043601.90346903
22Dilated cardiomyopathy_Homo sapiens_hsa054141.83024334
23GABAergic synapse_Homo sapiens_hsa047271.81041448
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.79682071
25Glutamatergic synapse_Homo sapiens_hsa047241.76615123
26Morphine addiction_Homo sapiens_hsa050321.76149094
27Amoebiasis_Homo sapiens_hsa051461.74050764
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68117631
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.68024880
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68009599
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.62716961
32Cardiac muscle contraction_Homo sapiens_hsa042601.56821205
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55928925
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.50920227
35Taste transduction_Homo sapiens_hsa047421.50638193
36Small cell lung cancer_Homo sapiens_hsa052221.46237513
37Prostate cancer_Homo sapiens_hsa052151.46173087
38Calcium signaling pathway_Homo sapiens_hsa040201.46128028
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.45634798
40Melanogenesis_Homo sapiens_hsa049161.37472192
41Pancreatic secretion_Homo sapiens_hsa049721.35950138
42Melanoma_Homo sapiens_hsa052181.35378939
43Pathways in cancer_Homo sapiens_hsa052001.34202738
44Viral myocarditis_Homo sapiens_hsa054161.30807927
45Chronic myeloid leukemia_Homo sapiens_hsa052201.30340610
46Serotonergic synapse_Homo sapiens_hsa047261.23253095
47Circadian rhythm_Homo sapiens_hsa047101.23141763
48p53 signaling pathway_Homo sapiens_hsa041151.21545849
49Nicotine addiction_Homo sapiens_hsa050331.21405067
50Dopaminergic synapse_Homo sapiens_hsa047281.20094750
51Cholinergic synapse_Homo sapiens_hsa047251.19647763
52Cell cycle_Homo sapiens_hsa041101.19510118
53Glioma_Homo sapiens_hsa052141.19146918
54Colorectal cancer_Homo sapiens_hsa052101.16261175
55Bladder cancer_Homo sapiens_hsa052191.11826572
56HTLV-I infection_Homo sapiens_hsa051661.09626150
57Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09428519
58Malaria_Homo sapiens_hsa051441.09130474
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04570276
60Pancreatic cancer_Homo sapiens_hsa052121.04126733
61Dorso-ventral axis formation_Homo sapiens_hsa043201.01499092
62Ovarian steroidogenesis_Homo sapiens_hsa049131.01377807
63Mineral absorption_Homo sapiens_hsa049781.00910476
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97551377
65Platelet activation_Homo sapiens_hsa046110.95509472
66Gap junction_Homo sapiens_hsa045400.95058757
67Thyroid hormone synthesis_Homo sapiens_hsa049180.93873545
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93498298
69Rap1 signaling pathway_Homo sapiens_hsa040150.90084990
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88904823
71Prion diseases_Homo sapiens_hsa050200.88424774
72Notch signaling pathway_Homo sapiens_hsa043300.86639088
73Tight junction_Homo sapiens_hsa045300.84716342
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82742731
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82328098
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80377202
77Bile secretion_Homo sapiens_hsa049760.79929057
78Endometrial cancer_Homo sapiens_hsa052130.79748614
79Pentose phosphate pathway_Homo sapiens_hsa000300.78499393
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77505528
81Alcoholism_Homo sapiens_hsa050340.77267812
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77048366
83Estrogen signaling pathway_Homo sapiens_hsa049150.76757758
84Cocaine addiction_Homo sapiens_hsa050300.75583076
85Insulin secretion_Homo sapiens_hsa049110.74665107
86Renal cell carcinoma_Homo sapiens_hsa052110.74461733
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73797372
88Lysine degradation_Homo sapiens_hsa003100.73203567
89N-Glycan biosynthesis_Homo sapiens_hsa005100.72756220
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.69353556
91Olfactory transduction_Homo sapiens_hsa047400.68564204
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68322701
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.67576031
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67147705
95Thyroid cancer_Homo sapiens_hsa052160.65448139
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64379616
97Glucagon signaling pathway_Homo sapiens_hsa049220.62818239
98Hepatitis B_Homo sapiens_hsa051610.60618372
99Choline metabolism in cancer_Homo sapiens_hsa052310.60597406
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58275332
101Viral carcinogenesis_Homo sapiens_hsa052030.57251950
102mTOR signaling pathway_Homo sapiens_hsa041500.57149282
103Systemic lupus erythematosus_Homo sapiens_hsa053220.55353232
104* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55224176
105Renin secretion_Homo sapiens_hsa049240.55151203
106cAMP signaling pathway_Homo sapiens_hsa040240.53978752
107GnRH signaling pathway_Homo sapiens_hsa049120.53862978
108Toxoplasmosis_Homo sapiens_hsa051450.52387074
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.52047698
110Non-small cell lung cancer_Homo sapiens_hsa052230.50493824
111TNF signaling pathway_Homo sapiens_hsa046680.49875579
112* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49572842
113Alzheimers disease_Homo sapiens_hsa050100.49157344
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48810654
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.46328358
116Insulin resistance_Homo sapiens_hsa049310.45924898
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45485918
118African trypanosomiasis_Homo sapiens_hsa051430.45079379
119Pertussis_Homo sapiens_hsa051330.44830323
120FoxO signaling pathway_Homo sapiens_hsa040680.44008679
121Shigellosis_Homo sapiens_hsa051310.43717096
122Ras signaling pathway_Homo sapiens_hsa040140.43612539
123Phagosome_Homo sapiens_hsa041450.43563049
124MAPK signaling pathway_Homo sapiens_hsa040100.42535547
125Vibrio cholerae infection_Homo sapiens_hsa051100.42312203
126* Renin-angiotensin system_Homo sapiens_hsa046140.41940930
127Amphetamine addiction_Homo sapiens_hsa050310.41428954
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.41335108
129Oocyte meiosis_Homo sapiens_hsa041140.41146493
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40952592
131ErbB signaling pathway_Homo sapiens_hsa040120.40865140
132AMPK signaling pathway_Homo sapiens_hsa041520.39431352
133Endocytosis_Homo sapiens_hsa041440.37650261
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37485899
135Oxytocin signaling pathway_Homo sapiens_hsa049210.37058713
136Type II diabetes mellitus_Homo sapiens_hsa049300.33544634
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33434371
138Phototransduction_Homo sapiens_hsa047440.29086462
139VEGF signaling pathway_Homo sapiens_hsa043700.28986719
140Fructose and mannose metabolism_Homo sapiens_hsa000510.25525026
141Inositol phosphate metabolism_Homo sapiens_hsa005620.22187720

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