AGXT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.81394060
2epoxygenase P450 pathway (GO:0019373)8.13411809
3omega-hydroxylase P450 pathway (GO:0097267)7.94257098
4L-phenylalanine catabolic process (GO:0006559)7.75478858
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.75478858
6L-phenylalanine metabolic process (GO:0006558)7.40287986
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.40287986
8aromatic amino acid family catabolic process (GO:0009074)6.93477437
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.42322681
10indole-containing compound catabolic process (GO:0042436)6.20859592
11indolalkylamine catabolic process (GO:0046218)6.20859592
12tryptophan catabolic process (GO:0006569)6.20859592
13kynurenine metabolic process (GO:0070189)6.06395461
14oxidative demethylation (GO:0070989)6.04642468
15drug metabolic process (GO:0017144)6.04029063
16bile acid biosynthetic process (GO:0006699)5.97548802
17tryptophan metabolic process (GO:0006568)5.84516159
18urea cycle (GO:0000050)5.83047105
19urea metabolic process (GO:0019627)5.83047105
20negative regulation of fibrinolysis (GO:0051918)5.73040303
21high-density lipoprotein particle remodeling (GO:0034375)5.70629957
22regulation of plasminogen activation (GO:0010755)5.65992349
23regulation of fibrinolysis (GO:0051917)5.51714426
24alpha-linolenic acid metabolic process (GO:0036109)5.51349884
25phenylpropanoid metabolic process (GO:0009698)5.47874358
26protein carboxylation (GO:0018214)5.42064075
27peptidyl-glutamic acid carboxylation (GO:0017187)5.42064075
28nitrogen cycle metabolic process (GO:0071941)5.36060818
29complement activation, alternative pathway (GO:0006957)5.34169126
30regulation of protein activation cascade (GO:2000257)5.31423261
31* glyoxylate metabolic process (GO:0046487)5.23464797
32bile acid metabolic process (GO:0008206)5.11343427
33* sulfur amino acid catabolic process (GO:0000098)5.05093901
34aromatic amino acid family metabolic process (GO:0009072)5.03473622
35regulation of cholesterol esterification (GO:0010872)4.99215789
36reverse cholesterol transport (GO:0043691)4.95782366
37homocysteine metabolic process (GO:0050667)4.95330970
38tyrosine metabolic process (GO:0006570)4.94577202
39regulation of complement activation (GO:0030449)4.94544377
40plasma lipoprotein particle remodeling (GO:0034369)4.88517079
41protein-lipid complex remodeling (GO:0034368)4.88517079
42macromolecular complex remodeling (GO:0034367)4.88517079
43ethanol metabolic process (GO:0006067)4.88238057
44regulation of triglyceride catabolic process (GO:0010896)4.87836502
45negative regulation of blood coagulation (GO:0030195)4.86243028
46negative regulation of hemostasis (GO:1900047)4.86243028
47* serine family amino acid catabolic process (GO:0009071)4.85116931
48* cysteine metabolic process (GO:0006534)4.82444773
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.82259644
50acute-phase response (GO:0006953)4.72493183
51S-adenosylmethionine metabolic process (GO:0046500)4.69160676
52acylglycerol homeostasis (GO:0055090)4.66333682
53triglyceride homeostasis (GO:0070328)4.66333682
54* alpha-amino acid catabolic process (GO:1901606)4.66111063
55alkaloid metabolic process (GO:0009820)4.64647634
56amino-acid betaine metabolic process (GO:0006577)4.64594592
57phospholipid efflux (GO:0033700)4.63319003
58negative regulation of cholesterol transport (GO:0032375)4.62613433
59negative regulation of sterol transport (GO:0032372)4.62613433
60regulation of humoral immune response (GO:0002920)4.61873028
61lysine metabolic process (GO:0006553)4.58788683
62lysine catabolic process (GO:0006554)4.58788683
63negative regulation of protein activation cascade (GO:2000258)4.48591571
64cellular ketone body metabolic process (GO:0046950)4.47897330
65plasma lipoprotein particle clearance (GO:0034381)4.47484526
66imidazole-containing compound metabolic process (GO:0052803)4.46077419
67negative regulation of coagulation (GO:0050819)4.42022961
68coenzyme catabolic process (GO:0009109)4.41151193
69bile acid and bile salt transport (GO:0015721)4.40921194
70indolalkylamine metabolic process (GO:0006586)4.40094341
71negative regulation of wound healing (GO:0061045)4.38017719
72cellular biogenic amine catabolic process (GO:0042402)4.31603200
73amine catabolic process (GO:0009310)4.31603200
74glutamate metabolic process (GO:0006536)4.30992129
75positive regulation of blood coagulation (GO:0030194)4.29295445
76positive regulation of hemostasis (GO:1900048)4.29295445
77cholesterol efflux (GO:0033344)4.29116286
78* cellular amino acid catabolic process (GO:0009063)4.28798749
79opsonization (GO:0008228)4.27877220
80cellular glucuronidation (GO:0052695)4.24209097
81benzene-containing compound metabolic process (GO:0042537)4.15220498
82arginine metabolic process (GO:0006525)4.13335251
83low-density lipoprotein particle remodeling (GO:0034374)4.13057031
84* glycine metabolic process (GO:0006544)4.12299063
85cellular modified amino acid catabolic process (GO:0042219)4.11952497
86dicarboxylic acid biosynthetic process (GO:0043650)4.08843897
87plasma lipoprotein particle assembly (GO:0034377)4.07483173
88fibrinolysis (GO:0042730)4.07076816
89* serine family amino acid metabolic process (GO:0009069)4.03900094
90ethanol oxidation (GO:0006069)4.02712068
91positive regulation of coagulation (GO:0050820)3.93552601
92blood coagulation, intrinsic pathway (GO:0007597)3.92539105
93drug catabolic process (GO:0042737)3.89399185
94ketone body metabolic process (GO:1902224)3.87754033
95intestinal cholesterol absorption (GO:0030299)3.87474966
96flavonoid metabolic process (GO:0009812)3.87146810
97cofactor catabolic process (GO:0051187)3.83436776
98negative regulation of lipase activity (GO:0060192)3.81978669
99very-low-density lipoprotein particle assembly (GO:0034379)3.80399290
100positive regulation of lipoprotein lipase activity (GO:0051006)3.80260871
101positive regulation of triglyceride lipase activity (GO:0061365)3.80260871
102negative regulation of complement activation (GO:0045916)3.79171442
103cholesterol homeostasis (GO:0042632)3.76549518
104regulation of lipoprotein particle clearance (GO:0010984)3.76541398
105uronic acid metabolic process (GO:0006063)3.76185918
106glucuronate metabolic process (GO:0019585)3.76185918
107positive regulation of lipid catabolic process (GO:0050996)3.75477099
108complement activation, classical pathway (GO:0006958)3.75168986
109* organic acid catabolic process (GO:0016054)3.74472743
110* carboxylic acid catabolic process (GO:0046395)3.74472743
111protein activation cascade (GO:0072376)3.74011590
112regulation of bile acid biosynthetic process (GO:0070857)3.73034933
113phospholipid homeostasis (GO:0055091)3.72896595
114complement activation (GO:0006956)3.72625690
115disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.70204054
116killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.70204054
117sterol homeostasis (GO:0055092)3.70139792
118plasma lipoprotein particle organization (GO:0071827)3.70085185
119hormone catabolic process (GO:0042447)3.69458406
120heme transport (GO:0015886)3.67603257
121acute inflammatory response (GO:0002526)3.66660845
122positive regulation of fatty acid biosynthetic process (GO:0045723)3.66485235
123protein-lipid complex assembly (GO:0065005)3.64984988
124acetyl-CoA metabolic process (GO:0006084)3.64871126
125short-chain fatty acid metabolic process (GO:0046459)3.63591554
126regulation of cholesterol homeostasis (GO:2000188)3.61815820
127cytolysis (GO:0019835)3.60275434
128* serine family amino acid biosynthetic process (GO:0009070)3.60225482
129NAD biosynthetic process (GO:0009435)3.58964180
130positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.54622595
131pyridine nucleotide biosynthetic process (GO:0019363)3.53622776
132nicotinamide nucleotide biosynthetic process (GO:0019359)3.53622776
133xenobiotic metabolic process (GO:0006805)3.43361812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.41629716
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.18791211
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.04861004
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.50177961
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.23177918
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.18171868
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.82105922
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03083363
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.02693028
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09591660
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0771869
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98710638
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94007651
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.60442227
15HTT_18923047_ChIP-ChIP_STHdh_Human1.58045641
16CLOCK_20551151_ChIP-Seq_293T_Human1.52460462
17GATA1_22025678_ChIP-Seq_K562_Human1.42927041
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39147573
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32086381
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30005639
21RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20286949
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17384855
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16347045
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10466309
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04617962
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01350829
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00891585
28IRF1_19129219_ChIP-ChIP_H3396_Human0.99746147
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93803665
30CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89969697
31SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89645784
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89463438
33ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88074378
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85965755
35TRIM28_21343339_ChIP-Seq_HEK293_Human0.85920982
36HNFA_21074721_ChIP-Seq_CACO-2_Human0.85250329
37* NFE2_27457419_Chip-Seq_LIVER_Mouse0.84482468
38AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83237694
39IRF8_22096565_ChIP-ChIP_GC-B_Human0.82326857
40RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82290473
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81839492
42PHF8_20622853_ChIP-Seq_HELA_Human0.81756049
43RAC3_21632823_ChIP-Seq_H3396_Human0.80147986
44ER_23166858_ChIP-Seq_MCF-7_Human0.79998625
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79111724
46GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78985881
47GATA4_25053715_ChIP-Seq_YYC3_Human0.78915257
48KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77273564
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76695748
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76381283
51SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75884059
52* SOX2_21211035_ChIP-Seq_LN229_Human0.75227657
53SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75226183
54GATA6_21074721_ChIP-Seq_CACO-2_Human0.74864208
55ZNF263_19887448_ChIP-Seq_K562_Human0.74422203
56EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.74224348
57RARA_24833708_ChIP-Seq_LIVER_Mouse0.74136307
58NFYA_21822215_ChIP-Seq_K562_Human0.72118453
59* EZH2_27294783_Chip-Seq_NPCs_Mouse0.70702151
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70603762
61SUZ12_27294783_Chip-Seq_NPCs_Mouse0.70408512
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69827533
63PIAS1_25552417_ChIP-Seq_VCAP_Human0.68398918
64CBX2_22325352_ChIP-Seq_293T-Rex_Human0.66096790
65SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65686876
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.65363238
67AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65254913
68IGF1R_20145208_ChIP-Seq_DFB_Human0.65064373
69* MYC_19829295_ChIP-Seq_ESCs_Human0.64953275
70ESR2_21235772_ChIP-Seq_MCF-7_Human0.64609752
71POU3F2_20337985_ChIP-ChIP_501MEL_Human0.64288299
72RARB_24833708_ChIP-Seq_LIVER_Mouse0.64093562
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63973939
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63903462
75NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63903462
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62554234
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62475946
78ETV1_20927104_ChIP-Seq_GIST48_Human0.62380325
79RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61921237
80TP53_18474530_ChIP-ChIP_U2OS_Human0.61762459
81BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61069462
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60368979
83* CRX_20693478_ChIP-Seq_RETINA_Mouse0.58728932
84* ERA_21632823_ChIP-Seq_H3396_Human0.57812923
85OCT4_20526341_ChIP-Seq_ESCs_Human0.57789848
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.57334717
87NANOG_19829295_ChIP-Seq_ESCs_Human0.57044552
88SOX2_19829295_ChIP-Seq_ESCs_Human0.57044552
89CEBPB_22108803_ChIP-Seq_LS180_Human0.56426877
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.56354620
91FOXA1_25329375_ChIP-Seq_VCAP_Human0.56354620
92SPI1_20517297_ChIP-Seq_HL60_Human0.55923965
93EGR1_19032775_ChIP-ChIP_M12_Human0.55352365
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.54403459
95PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.54332373
96LXR_22292898_ChIP-Seq_THP-1_Human0.53971292
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.53360684
98CDX2_22108803_ChIP-Seq_LS180_Human0.53171983
99FOXA1_25552417_ChIP-Seq_VCAP_Human0.52529699
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52503427
101* E2F1_20622854_ChIP-Seq_HELA_Human0.52091987
102AR_20517297_ChIP-Seq_VCAP_Human0.52076390
103ELF1_20517297_ChIP-Seq_JURKAT_Human0.51961097
104MYC_19915707_ChIP-ChIP_AK7_Human0.51787584
105GATA3_21878914_ChIP-Seq_MCF-7_Human0.51351039
106RBPJ_21746931_ChIP-Seq_IB4_Human0.51078821
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50999150
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.50978328
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.50240175
110* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50102778
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49205252
112ESET_19884257_ChIP-Seq_ESCs_Mouse0.48323623
113CBP_21632823_ChIP-Seq_H3396_Human0.47498712
114P53_21459846_ChIP-Seq_SAOS-2_Human0.47011606
115STAT1_17558387_ChIP-Seq_HELA_Human0.46461703
116TAF15_26573619_Chip-Seq_HEK293_Human0.45943655
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43632273
118* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43412503
119GATA1_19941826_ChIP-Seq_K562_Human0.43273693
120TAF2_19829295_ChIP-Seq_ESCs_Human0.42558247
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.42450007
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.42375250
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.41725243
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.41416543
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.41223407
126* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40810909
127* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40549934
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40056731
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.39817341
130GATA2_19941826_ChIP-Seq_K562_Human0.39602598
131MYC_27129775_Chip-Seq_CORNEA_Mouse0.38844535
132BCAT_22108803_ChIP-Seq_LS180_Human0.38801893
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.37464595
134STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37230793
135* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37230588
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.37078304
137GATA6_25053715_ChIP-Seq_YYC3_Human0.36947335
138LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36771681
139SPI1_26923725_Chip-Seq_HPCs_Mouse0.35394813
140NCOR_22424771_ChIP-Seq_293T_Human0.33879236
141FOXH1_21741376_ChIP-Seq_EPCs_Human0.33855267
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33788330
143SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.33181610
144* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.32795510
145ERG_20517297_ChIP-Seq_VCAP_Human0.32794720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.45545248
2* MP0005360_urolithiasis6.87812408
3MP0005085_abnormal_gallbladder_physiolo6.60166019
4MP0005365_abnormal_bile_salt6.31338201
5MP0008875_abnormal_xenobiotic_pharmacok5.25530058
6MP0003806_abnormal_nucleotide_metabolis4.35106196
7MP0003252_abnormal_bile_duct3.99157844
8MP0010329_abnormal_lipoprotein_level3.68706164
9MP0009840_abnormal_foam_cell3.40426312
10MP0005083_abnormal_biliary_tract3.11823324
11MP0005332_abnormal_amino_acid2.85882213
12MP0001666_abnormal_nutrient_absorption2.63683714
13MP0003191_abnormal_cellular_cholesterol2.41620911
14MP0000609_abnormal_liver_physiology2.21334584
15MP0004019_abnormal_vitamin_homeostasis2.17583949
16MP0002118_abnormal_lipid_homeostasis2.14760522
17MP0002138_abnormal_hepatobiliary_system2.03181114
18MP0003868_abnormal_feces_composition1.95914691
19MP0005319_abnormal_enzyme/_coenzyme1.87207869
20MP0001764_abnormal_homeostasis1.74892142
21MP0009697_abnormal_copulation1.65046472
22MP0005584_abnormal_enzyme/coenzyme_acti1.61610091
23MP0005451_abnormal_body_composition1.53600681
24* MP0003195_calcinosis1.48124531
25MP0003011_delayed_dark_adaptation1.43243433
26MP0003656_abnormal_erythrocyte_physiolo1.32807234
27MP0003186_abnormal_redox_activity1.31597810
28MP0000598_abnormal_liver_morphology1.21433503
29MP0003705_abnormal_hypodermis_morpholog1.21427423
30* MP0009643_abnormal_urine_homeostasis1.20174681
31MP0005647_abnormal_sex_gland1.14475374
32MP0000604_amyloidosis1.13409452
33MP0009764_decreased_sensitivity_to1.08056648
34MP0009763_increased_sensitivity_to1.04981065
35MP0002254_reproductive_system_inflammat1.03613012
36MP0010368_abnormal_lymphatic_system1.00218143
37MP0005636_abnormal_mineral_homeostasis0.94356720
38MP0005187_abnormal_penis_morphology0.91968072
39MP0008469_abnormal_protein_level0.91317245
40MP0009642_abnormal_blood_homeostasis0.89838476
41MP0005408_hypopigmentation0.87736013
42MP0002282_abnormal_trachea_morphology0.84026123
43MP0006036_abnormal_mitochondrial_physio0.83495885
44MP0005376_homeostasis/metabolism_phenot0.83431627
45MP0001915_intracranial_hemorrhage0.81936650
46MP0005670_abnormal_white_adipose0.80346250
47MP0009765_abnormal_xenobiotic_induced0.80288906
48MP0002078_abnormal_glucose_homeostasis0.79525809
49MP0003879_abnormal_hair_cell0.76888137
50MP0002876_abnormal_thyroid_physiology0.76573245
51MP0005084_abnormal_gallbladder_morpholo0.75977933
52MP0002971_abnormal_brown_adipose0.73536506
53MP0005220_abnormal_exocrine_pancreas0.72865345
54MP0003690_abnormal_glial_cell0.69762458
55MP0004130_abnormal_muscle_cell0.69713397
56MP0001661_extended_life_span0.69520560
57MP0005334_abnormal_fat_pad0.69445892
58MP0005535_abnormal_body_temperature0.68629492
59MP0009053_abnormal_anal_canal0.68329084
60MP0005266_abnormal_metabolism0.66834256
61MP0000639_abnormal_adrenal_gland0.64571396
62MP0003329_amyloid_beta_deposits0.64436085
63MP0002249_abnormal_larynx_morphology0.63593472
64MP0001756_abnormal_urination0.60169793
65MP0000566_synostosis0.57439932
66MP0005448_abnormal_energy_balance0.57318873
67MP0006035_abnormal_mitochondrial_morpho0.57059109
68MP0005464_abnormal_platelet_physiology0.56755022
69MP0002822_catalepsy0.52256090
70MP0009785_altered_susceptibility_to0.51904791
71MP0003638_abnormal_response/metabolism_0.48279537
72MP0008874_decreased_physiological_sensi0.48212910
73MP0003718_maternal_effect0.47271889
74MP0008873_increased_physiological_sensi0.46815169
75MP0003436_decreased_susceptibility_to0.45222568
76MP0002928_abnormal_bile_duct0.44805193
77MP0002837_dystrophic_cardiac_calcinosis0.44667182
78MP0003724_increased_susceptibility_to0.44078238
79MP0004782_abnormal_surfactant_physiolog0.43913280
80MP0003075_altered_response_to0.42999461
81MP0001986_abnormal_taste_sensitivity0.42597995
82MP0003953_abnormal_hormone_level0.41632706
83MP0005248_abnormal_Harderian_gland0.41360131
84* MP0002136_abnormal_kidney_physiology0.40990286
85MP0008872_abnormal_physiological_respon0.39727476
86MP0004381_abnormal_hair_follicle0.39056637
87MP0005166_decreased_susceptibility_to0.38828804
88MP0009672_abnormal_birth_weight0.38335635
89MP0005666_abnormal_adipose_tissue0.36708666
90* MP0005395_other_phenotype0.36063851
91MP0004883_abnormal_blood_vessel0.35511512
92MP0000249_abnormal_blood_vessel0.35209761
93MP0000579_abnormal_nail_morphology0.34413412
94MP0000230_abnormal_systemic_arterial0.33750085
95MP0001243_abnormal_dermal_layer0.33280920
96MP0009115_abnormal_fat_cell0.32916797
97MP0006082_CNS_inflammation0.32848374
98MP0002796_impaired_skin_barrier0.32438807
99MP0009384_cardiac_valve_regurgitation0.31572860
100MP0002970_abnormal_white_adipose0.30723267
101MP0010386_abnormal_urinary_bladder0.29731302
102MP0001853_heart_inflammation0.29679495
103MP0005646_abnormal_pituitary_gland0.29663177
104MP0001845_abnormal_inflammatory_respons0.29353849
105MP0005023_abnormal_wound_healing0.29104188
106MP0001881_abnormal_mammary_gland0.27926283
107MP0006292_abnormal_olfactory_placode0.27652209
108MP0005164_abnormal_response_to0.27429859
109MP0005551_abnormal_eye_electrophysiolog0.26439418
110MP0000467_abnormal_esophagus_morphology0.25970381
111MP0002132_abnormal_respiratory_system0.25187119
112MP0002089_abnormal_postnatal_growth/wei0.25102086
113MP0001944_abnormal_pancreas_morphology0.24638525
114MP0002090_abnormal_vision0.24526699
115MP0005167_abnormal_blood-brain_barrier0.23896479
116MP0005058_abnormal_lysosome_morphology0.23694179
117MP0003959_abnormal_lean_body0.23539577
118MP0002909_abnormal_adrenal_gland0.23441719
119MP0004142_abnormal_muscle_tone0.23279100
120MP0005377_hearing/vestibular/ear_phenot0.21195623

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.56769486
2Deep venous thrombosis (HP:0002625)7.49291769
3Intrahepatic cholestasis (HP:0001406)7.35806843
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.79309109
5Prolonged partial thromboplastin time (HP:0003645)6.63678697
6Hypobetalipoproteinemia (HP:0003563)6.49870657
7Xanthomatosis (HP:0000991)6.32671228
8Hyperlipoproteinemia (HP:0010980)5.69563632
9Complement deficiency (HP:0004431)5.30641659
10Joint hemorrhage (HP:0005261)4.88021776
11Hypolipoproteinemia (HP:0010981)4.87592043
12Hyperammonemia (HP:0001987)4.65687026
13Epidermoid cyst (HP:0200040)4.55201675
14Abnormality of the common coagulation pathway (HP:0010990)4.50323573
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.46052882
16Abnormality of methionine metabolism (HP:0010901)4.43585178
17Hyperglycinemia (HP:0002154)4.40003426
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.36644010
19Hypoalphalipoproteinemia (HP:0003233)4.28207633
20Ketosis (HP:0001946)4.25316856
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22399745
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.20261463
23Fat malabsorption (HP:0002630)4.10948220
24Abnormality of pyrimidine metabolism (HP:0004353)3.93628442
25Hyperglycinuria (HP:0003108)3.90836549
26Abnormality of serine family amino acid metabolism (HP:0010894)3.88783650
27Abnormality of glycine metabolism (HP:0010895)3.88783650
28Abnormality of complement system (HP:0005339)3.87351043
29Hypoglycemic coma (HP:0001325)3.79781224
30Abnormality of the intrinsic pathway (HP:0010989)3.78441764
31Conjugated hyperbilirubinemia (HP:0002908)3.70538637
32Hypercholesterolemia (HP:0003124)3.65404803
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36324185
34Hyperbilirubinemia (HP:0002904)3.35953728
35Abnormality of fatty-acid metabolism (HP:0004359)3.32470140
36Delayed CNS myelination (HP:0002188)3.11696474
37Abnormality of serum amino acid levels (HP:0003112)3.09230254
38Spontaneous abortion (HP:0005268)3.08722454
39Steatorrhea (HP:0002570)3.08295069
40Abnormality of nucleobase metabolism (HP:0010932)3.07587244
41Hepatocellular carcinoma (HP:0001402)3.02168317
42Hypochromic microcytic anemia (HP:0004840)2.98348437
43Ketoacidosis (HP:0001993)2.96176854
44Myocardial infarction (HP:0001658)2.95849229
45Skin nodule (HP:0200036)2.81754021
46Systemic lupus erythematosus (HP:0002725)2.69921781
47Abnormality of purine metabolism (HP:0004352)2.64566645
48Lethargy (HP:0001254)2.62617043
49Reduced antithrombin III activity (HP:0001976)2.62033717
50* Metabolic acidosis (HP:0001942)2.60604925
51Vascular calcification (HP:0004934)2.60283712
52Acanthocytosis (HP:0001927)2.58572549
53Purpura (HP:0000979)2.58297041
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56966758
55Dicarboxylic aciduria (HP:0003215)2.56966758
56Fair hair (HP:0002286)2.56195712
57Osteomalacia (HP:0002749)2.52666811
58Spastic diplegia (HP:0001264)2.48348695
59Glomerulonephritis (HP:0000099)2.48164905
60Cerebral edema (HP:0002181)2.48110282
61Abnormal gallbladder morphology (HP:0012437)2.46987549
62Mitral stenosis (HP:0001718)2.45437964
63Gout (HP:0001997)2.42757212
64Cholelithiasis (HP:0001081)2.39981138
65Hypoglycemic seizures (HP:0002173)2.39841777
66Neonatal onset (HP:0003623)2.38947898
67Irritability (HP:0000737)2.38024819
68Amyloidosis (HP:0011034)2.37475982
69Cardiovascular calcification (HP:0011915)2.30948514
70Recurrent gram-negative bacterial infections (HP:0005420)2.30024677
71Gingival bleeding (HP:0000225)2.26300937
72Abnormal gallbladder physiology (HP:0012438)2.24990050
73Cholecystitis (HP:0001082)2.24990050
74Malnutrition (HP:0004395)2.22767682
75Esophageal varix (HP:0002040)2.19890498
76Menorrhagia (HP:0000132)2.19625961
77Arthropathy (HP:0003040)2.18781590
78Neonatal hypoglycemia (HP:0001998)2.17053169
79Pancreatitis (HP:0001733)2.14500447
80Thrombophlebitis (HP:0004418)2.12575105
81Enlarged kidneys (HP:0000105)2.11642589
82Sensorimotor neuropathy (HP:0007141)2.11541166
83Brushfield spots (HP:0001088)2.11056373
84Hyperphosphaturia (HP:0003109)2.08212675
85Vomiting (HP:0002013)2.07305796
86Late onset (HP:0003584)2.05267371
87Poikilocytosis (HP:0004447)2.04018811
88Opisthotonus (HP:0002179)2.01349606
89Generalized aminoaciduria (HP:0002909)2.01012838
90Glycosuria (HP:0003076)2.00958998
91Abnormality of urine glucose concentration (HP:0011016)2.00958998
92Abnormality of the gallbladder (HP:0005264)1.99899572
93Hemorrhage of the eye (HP:0011885)1.99891176
94Hyperinsulinemic hypoglycemia (HP:0000825)1.93731130
95Abnormality of iron homeostasis (HP:0011031)1.93199837
96Rickets (HP:0002748)1.91419088
97Bile duct proliferation (HP:0001408)1.90340457
98Abnormal biliary tract physiology (HP:0012439)1.90340457
99Abnormality of transition element cation homeostasis (HP:0011030)1.88778432
100Abnormal cartilage morphology (HP:0002763)1.87388677
101Hypophosphatemic rickets (HP:0004912)1.86512067
102Alkalosis (HP:0001948)1.86460930
103Increased serum ferritin (HP:0003281)1.86148555
104Elevated alkaline phosphatase (HP:0003155)1.84565053
105Abnormality of the Achilles tendon (HP:0005109)1.83335098
106Hydroxyprolinuria (HP:0003080)1.83218546
107Abnormality of proline metabolism (HP:0010907)1.83218546
108Renal cortical cysts (HP:0000803)1.83086290
109Elevated hepatic transaminases (HP:0002910)1.81701797
110Abnormal enzyme/coenzyme activity (HP:0012379)1.79852512
111Bifid scrotum (HP:0000048)1.78830552
112Status epilepticus (HP:0002133)1.78586181
113Generalized hypopigmentation of hair (HP:0011358)1.77420412
114Nephritis (HP:0000123)1.75785684
115Abnormality of vitamin metabolism (HP:0100508)1.72217584
116Pulmonary embolism (HP:0002204)1.71998309
117Abnormality of alkaline phosphatase activity (HP:0004379)1.70678740
118Cerebral palsy (HP:0100021)1.67803928
119Joint swelling (HP:0001386)1.66007903
120Abnormal urine phosphate concentration (HP:0012599)1.64353439
121Epistaxis (HP:0000421)1.59897481
122Increased serum pyruvate (HP:0003542)1.54183518
123Blue irides (HP:0000635)1.51452698
124Increased mean platelet volume (HP:0011877)1.50457792
125Retinal atrophy (HP:0001105)1.48917846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.30155130
2FGFR44.69528355
3SIK14.56512019
4ERN14.30532413
5TAOK33.02466455
6INSRR2.95812126
7ERBB42.87664453
8PIK3CA2.50976428
9MAP2K42.35973809
10PKN22.27601630
11NTRK32.12472409
12MST1R2.08670979
13FLT31.93972213
14MAPK111.88715853
15PIK3CG1.81414305
16TRIB31.80922530
17WNK31.79255032
18TYK21.73782647
19LATS11.60954364
20DAPK21.58813602
21ABL21.49704957
22PTK61.49529411
23WNK41.48934347
24FGFR21.40029660
25CAMKK21.39812545
26NEK91.34313084
27KDR1.32869849
28FRK1.32100332
29JAK21.23021300
30MAP3K71.18741723
31PINK11.16049865
32TNK21.14354015
33MAP4K21.13888947
34PRKACA1.12415386
35PRKG11.12052823
36ADRBK21.09498150
37PRKAA21.09081322
38GRK61.08548048
39TBK11.07223804
40MAP2K31.04692215
41ERBB21.03788810
42MAP3K101.02594124
43JAK11.02120735
44MAPK40.99418897
45CSNK1D0.95030256
46MAP3K140.94285130
47ACVR1B0.93203063
48PRKCZ0.92865789
49EPHB10.88661097
50MAPK150.87594423
51NLK0.86906193
52MET0.84796979
53PDK20.82654864
54MAPK120.82549235
55STK38L0.81290283
56CDK60.80912859
57TIE10.79453777
58MAP3K30.79422145
59EPHA30.78190083
60MAP3K110.78059615
61MUSK0.77937238
62PRKACG0.76545711
63MAPKAPK30.76078786
64AKT30.75314208
65FER0.73786021
66CAMK2G0.72257123
67CSK0.70408246
68DYRK1B0.70024624
69SGK10.68722568
70STK160.68692030
71MAP2K60.67685743
72BMPR1B0.66270186
73GSK3A0.66228253
74PRKCB0.64765081
75PRKAA10.64112923
76CAMKK10.63687523
77CASK0.62582789
78SGK30.61998340
79RPS6KA30.60496533
80DYRK20.60297042
81MAPK70.60001580
82CAMK1D0.59587765
83CSF1R0.59558953
84MAP3K120.59214173
85RIPK10.58121730
86FGFR30.57753787
87PRKACB0.57527923
88TGFBR20.57511023
89IRAK30.57398978
90CSNK2A10.57224733
91PTK20.57206002
92IKBKE0.55290443
93CSNK1E0.54080819
94CSNK1G10.53065744
95PRKCQ0.53057717
96PDPK10.52577177
97CSNK1A10.52159470
98PRKCE0.51140502
99EPHA40.50782692
100MYLK0.49997451
101MAP3K20.48132940
102CSNK2A20.48046280
103BCR0.47093267
104GRK10.46299995
105SGK20.44911076
106TAOK20.44515033
107IGF1R0.43646762
108PRKCG0.42966503
109RET0.41709787
110MAP2K10.41660161
111MAP3K50.41407562
112CDK40.41102619
113MAP3K130.40992699
114PBK0.39080619
115TLK10.38773278
116PKN10.38622214
117ICK0.38446707
118CHUK0.36941739
119SRC0.36834484
120MTOR0.34429070
121CSNK1G20.34230048
122DYRK1A0.33811414
123EGFR0.33278587
124MAP3K60.33224767
125CSNK1G30.32823398
126PDK10.32351074
127CAMK40.32092666
128SGK2230.31700729
129SGK4940.31700729
130BRSK20.30909596
131MAP3K10.26508034
132PRKCA0.25945175
133LATS20.25112893
134IRAK20.24329704
135IRAK10.24110990
136CSNK1A1L0.23215319
137MAP2K20.20937254
138ABL10.20462838
139PAK30.20389183
140BMX0.19280414
141MAPK30.18089494

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.54780505
2Nitrogen metabolism_Homo sapiens_hsa009103.71325486
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.49707681
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35453025
5Arginine biosynthesis_Homo sapiens_hsa002203.16170558
6Complement and coagulation cascades_Homo sapiens_hsa046102.79916197
7Tryptophan metabolism_Homo sapiens_hsa003802.68829237
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66231899
9* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.47267262
10* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46845813
11Fatty acid degradation_Homo sapiens_hsa000712.46813513
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37403417
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24107677
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13421930
15Butanoate metabolism_Homo sapiens_hsa006502.13272145
16* Peroxisome_Homo sapiens_hsa041462.01054674
17Chemical carcinogenesis_Homo sapiens_hsa052041.96511265
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.93860357
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93512441
20Histidine metabolism_Homo sapiens_hsa003401.92087279
21Propanoate metabolism_Homo sapiens_hsa006401.91071034
22PPAR signaling pathway_Homo sapiens_hsa033201.85806779
23Staphylococcus aureus infection_Homo sapiens_hsa051501.78433517
24Fatty acid metabolism_Homo sapiens_hsa012121.77968553
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.77855618
26Caffeine metabolism_Homo sapiens_hsa002321.76661668
27beta-Alanine metabolism_Homo sapiens_hsa004101.70469293
28Retinol metabolism_Homo sapiens_hsa008301.69443771
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65953231
30* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63344135
31Selenocompound metabolism_Homo sapiens_hsa004501.62698580
32Phenylalanine metabolism_Homo sapiens_hsa003601.60985440
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60812245
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54851951
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52814829
36Bile secretion_Homo sapiens_hsa049761.49087098
37Tyrosine metabolism_Homo sapiens_hsa003501.46799616
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.38409748
39Sulfur metabolism_Homo sapiens_hsa009201.37022849
40Pyruvate metabolism_Homo sapiens_hsa006201.33430760
41Fatty acid elongation_Homo sapiens_hsa000621.32456966
42Starch and sucrose metabolism_Homo sapiens_hsa005001.26073301
43Biosynthesis of amino acids_Homo sapiens_hsa012301.23226513
44Folate biosynthesis_Homo sapiens_hsa007901.22898222
45Steroid biosynthesis_Homo sapiens_hsa001001.22233740
46ABC transporters_Homo sapiens_hsa020101.19314782
47Fat digestion and absorption_Homo sapiens_hsa049751.16136640
48* Carbon metabolism_Homo sapiens_hsa012001.06230504
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04885544
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97786378
51Arginine and proline metabolism_Homo sapiens_hsa003300.97709931
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.97653351
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.96673463
54Sulfur relay system_Homo sapiens_hsa041220.95491337
55Vitamin B6 metabolism_Homo sapiens_hsa007500.90889291
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87211921
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85836340
58Vitamin digestion and absorption_Homo sapiens_hsa049770.85731009
59Lysine degradation_Homo sapiens_hsa003100.80123459
60One carbon pool by folate_Homo sapiens_hsa006700.77423684
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68409787
62Glycerolipid metabolism_Homo sapiens_hsa005610.64928868
63Glutathione metabolism_Homo sapiens_hsa004800.63733141
64Pentose phosphate pathway_Homo sapiens_hsa000300.57625600
65Fatty acid biosynthesis_Homo sapiens_hsa000610.50680285
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46347459
67* Metabolic pathways_Homo sapiens_hsa011000.45823732
68Prion diseases_Homo sapiens_hsa050200.35164050
69Pertussis_Homo sapiens_hsa051330.33949469
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32935326
71Galactose metabolism_Homo sapiens_hsa000520.24560695
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23722054
73Linoleic acid metabolism_Homo sapiens_hsa005910.22820530
74Insulin resistance_Homo sapiens_hsa049310.22595602
75Fructose and mannose metabolism_Homo sapiens_hsa000510.22196187
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.21777618
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19493793
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.15605376
79Glucagon signaling pathway_Homo sapiens_hsa049220.09229938
80AMPK signaling pathway_Homo sapiens_hsa041520.01618020
81Other glycan degradation_Homo sapiens_hsa005110.01236972
82Mineral absorption_Homo sapiens_hsa049780.00651714
83Serotonergic synapse_Homo sapiens_hsa047260.00276115
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2443870
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2421581
86Amoebiasis_Homo sapiens_hsa05146-0.2416276
87Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2351547
88Type II diabetes mellitus_Homo sapiens_hsa04930-0.2286921
89Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2266736
90N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2123344
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2027074
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1930071
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1882760
94Renin-angiotensin system_Homo sapiens_hsa04614-0.1862844
95Hepatitis C_Homo sapiens_hsa05160-0.1837126
96Circadian rhythm_Homo sapiens_hsa04710-0.1711390
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1669192
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1638120
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1598911
100Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1576527
101Sphingolipid metabolism_Homo sapiens_hsa00600-0.1552351
102Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1468160
103Regulation of autophagy_Homo sapiens_hsa04140-0.1380818
104African trypanosomiasis_Homo sapiens_hsa05143-0.1347840
105Insulin signaling pathway_Homo sapiens_hsa04910-0.1076372
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0893112
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0870025
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0648191
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0393402

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