AHCYL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene acts as a homotetramer and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)4.28910251
2surfactant homeostasis (GO:0043129)4.27174979
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.22000125
4sodium ion export (GO:0071436)4.21065428
5sulfate transmembrane transport (GO:1902358)4.04593165
6locomotory exploration behavior (GO:0035641)3.95657524
7synaptic vesicle maturation (GO:0016188)3.88862724
8cGMP-mediated signaling (GO:0019934)3.88065916
9ionotropic glutamate receptor signaling pathway (GO:0035235)3.75470391
10vocalization behavior (GO:0071625)3.70964852
11glutamate secretion (GO:0014047)3.69099202
12chemical homeostasis within a tissue (GO:0048875)3.64035120
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.60726123
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.55209534
15proline transport (GO:0015824)3.52635302
16sulfate transport (GO:0008272)3.41181966
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.41076879
18cellular sodium ion homeostasis (GO:0006883)3.40949480
19sperm capacitation (GO:0048240)3.39577418
20glomerular filtration (GO:0003094)3.32365782
21synaptic vesicle exocytosis (GO:0016079)3.26243617
22positive regulation of respiratory burst (GO:0060267)3.23077777
23glutamate receptor signaling pathway (GO:0007215)3.22845684
24regulation of glutamate receptor signaling pathway (GO:1900449)3.21511334
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.21317011
26ethanol oxidation (GO:0006069)3.18430873
27regulation of synapse structural plasticity (GO:0051823)3.10138634
28receptor guanylyl cyclase signaling pathway (GO:0007168)3.08553990
29glycine transport (GO:0015816)3.08153247
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.07260142
31synaptic transmission, glutamatergic (GO:0035249)3.05313173
32renal filtration (GO:0097205)3.03800323
33regulation of ARF protein signal transduction (GO:0032012)3.02205483
34regulation of synaptic vesicle exocytosis (GO:2000300)3.01978156
35potassium ion import (GO:0010107)3.00992365
36macroautophagy (GO:0016236)2.98849714
37cell communication by electrical coupling (GO:0010644)2.97471321
38regulation of guanylate cyclase activity (GO:0031282)2.97048738
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.95149939
40neurotransmitter secretion (GO:0007269)2.89428450
41regulation of synaptic vesicle transport (GO:1902803)2.86256857
42regulation of neuronal synaptic plasticity (GO:0048168)2.85714990
43exploration behavior (GO:0035640)2.85590806
44renal system process involved in regulation of blood volume (GO:0001977)2.85069104
45long-term memory (GO:0007616)2.83982419
46potassium ion homeostasis (GO:0055075)2.78844282
47regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.76591739
48negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75236371
49postsynaptic membrane organization (GO:0001941)2.74448974
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.74027843
51bundle of His cell to Purkinje myocyte communication (GO:0086069)2.73876961
52signal complex assembly (GO:0007172)2.72796582
53activation of protein kinase A activity (GO:0034199)2.72059283
54receptor recycling (GO:0001881)2.69907479
55regulation of long-term neuronal synaptic plasticity (GO:0048169)2.68833466
56transcytosis (GO:0045056)2.68713570
57axon ensheathment in central nervous system (GO:0032291)2.66784831
58central nervous system myelination (GO:0022010)2.66784831
59neuron-neuron synaptic transmission (GO:0007270)2.64673379
60membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.63527191
61neuronal action potential propagation (GO:0019227)2.63031032
62cellular glucuronidation (GO:0052695)2.61508898
63activation of MAPKKK activity (GO:0000185)2.61155322
64cell communication involved in cardiac conduction (GO:0086065)2.59709449
65membrane repolarization (GO:0086009)2.58134496
66bicarbonate transport (GO:0015701)2.57949696
67membrane hyperpolarization (GO:0060081)2.57013335
68nerve growth factor signaling pathway (GO:0038180)2.55437112
69presynaptic membrane assembly (GO:0097105)2.53885317
70regulation of protein glycosylation (GO:0060049)2.52265961
71negative regulation of myotube differentiation (GO:0010832)2.51868032
72G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51425517
73cellular response to nitric oxide (GO:0071732)2.50509950
74ethanol metabolic process (GO:0006067)2.49825019
75neurotransmitter transport (GO:0006836)2.49723993
76gamma-aminobutyric acid transport (GO:0015812)2.48956288
77membrane repolarization during action potential (GO:0086011)2.48723751
78amino acid import (GO:0043090)2.47802394
79phosphate ion transmembrane transport (GO:0035435)2.47369597
80L-amino acid import (GO:0043092)2.46497044
81O-glycan processing (GO:0016266)2.46465829
82protein localization to synapse (GO:0035418)2.46377292
83cellular response to reactive nitrogen species (GO:1902170)2.45649280
84regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.45580554
85glucocorticoid biosynthetic process (GO:0006704)2.44446095
86alanine transport (GO:0032328)2.44300042
87regulation of synaptic plasticity (GO:0048167)2.43523814
88regulation of excitatory postsynaptic membrane potential (GO:0060079)2.42931651
89regulation of vesicle fusion (GO:0031338)2.42589697
90neurotransmitter-gated ion channel clustering (GO:0072578)2.42294362
91membrane depolarization during action potential (GO:0086010)2.42188673
92cGMP biosynthetic process (GO:0006182)2.41581063
93flavonoid metabolic process (GO:0009812)2.41464961
94establishment of nucleus localization (GO:0040023)2.39647811
95positive regulation of fatty acid beta-oxidation (GO:0032000)2.39321518
96monovalent inorganic cation homeostasis (GO:0055067)2.39269284
97glucuronate metabolic process (GO:0019585)2.38949435
98uronic acid metabolic process (GO:0006063)2.38949435
99dendrite morphogenesis (GO:0048813)2.38868234
100sodium ion homeostasis (GO:0055078)2.38222447
101multicellular organismal water homeostasis (GO:0050891)2.38134263
102water transport (GO:0006833)2.37963270
103long-term synaptic potentiation (GO:0060291)2.35297464
104one-carbon compound transport (GO:0019755)2.34805049
105presynaptic membrane organization (GO:0097090)2.34637466
106labyrinthine layer development (GO:0060711)2.34410681
107positive regulation of membrane potential (GO:0045838)2.34099991
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.33791010
109layer formation in cerebral cortex (GO:0021819)2.33518114
110positive regulation of potassium ion transmembrane transport (GO:1901381)2.31766763
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.30946185
112response to histamine (GO:0034776)2.30716873
113neuromuscular process controlling balance (GO:0050885)2.30395372
114astrocyte differentiation (GO:0048708)2.29926334
115regulation of cell communication by electrical coupling (GO:0010649)2.29219944
116calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.28870260
117regulation of postsynaptic membrane potential (GO:0060078)2.28517564
118negative regulation of protein localization to cell surface (GO:2000009)2.26783703
119cerebellar Purkinje cell differentiation (GO:0021702)2.26768229
120regulation of calcium ion-dependent exocytosis (GO:0017158)2.26424047
121negative regulation of leukocyte chemotaxis (GO:0002689)2.25924891
122long term synaptic depression (GO:0060292)2.25750426
123negative regulation of hormone metabolic process (GO:0032351)2.25426567
124negative regulation of hormone biosynthetic process (GO:0032353)2.25426567
125oligosaccharide biosynthetic process (GO:0009312)2.25224384
126ventricular cardiac muscle cell action potential (GO:0086005)2.24958535
127fluid transport (GO:0042044)2.24242226
128lipid translocation (GO:0034204)2.23570441
129phospholipid translocation (GO:0045332)2.23570441
130positive regulation of vesicle fusion (GO:0031340)2.23019412
131regulation of cardiac muscle cell contraction (GO:0086004)2.23000645
132regulation of clathrin-mediated endocytosis (GO:2000369)2.22384507
133positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.21601793
134regulation of neurotransmitter levels (GO:0001505)2.21358352
135dendritic spine morphogenesis (GO:0060997)2.21202340
136membrane assembly (GO:0071709)2.20372925
137regulation of beta-amyloid formation (GO:1902003)2.20268765
138chloride transmembrane transport (GO:1902476)2.20118596
139sodium ion transmembrane transport (GO:0035725)2.20111339
140negative regulation of amino acid transport (GO:0051956)2.19662707
141membrane depolarization (GO:0051899)2.17964158
142regulation of synaptic transmission, glutamatergic (GO:0051966)2.17894971
143relaxation of cardiac muscle (GO:0055119)2.17518303
144renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.17134353
145peptidyl-tyrosine autophosphorylation (GO:0038083)2.16743937
146peripheral nervous system development (GO:0007422)2.16445154
147regulation of pseudopodium assembly (GO:0031272)2.16125589
148protein localization to endosome (GO:0036010)2.15923826
149response to auditory stimulus (GO:0010996)2.15759587
150cardiac conduction (GO:0061337)2.15412247
151gamma-aminobutyric acid signaling pathway (GO:0007214)2.15392938
152endocrine process (GO:0050886)2.15278393
153regulation of systemic arterial blood pressure by hormone (GO:0001990)2.15278393
154regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.15278393
155excretion (GO:0007588)2.14990932
156inorganic anion transmembrane transport (GO:0098661)2.14784012
157negative regulation of neurotransmitter secretion (GO:0046929)2.14189837
158auditory receptor cell differentiation (GO:0042491)2.14171554
159renal absorption (GO:0070293)2.13657050
160intestinal absorption (GO:0050892)2.09957047
161vesicle transport along microtubule (GO:0047496)2.08621961
162positive regulation of potassium ion transport (GO:0043268)2.05980481
163protein targeting to Golgi (GO:0000042)2.05792631
164regulation of dendritic spine morphogenesis (GO:0061001)2.04908702
165transmission of nerve impulse (GO:0019226)2.04855087
166positive regulation of heat generation (GO:0031652)2.04032677
167inner ear receptor cell development (GO:0060119)2.03754601
168establishment of protein localization to Golgi (GO:0072600)2.02832601
169positive regulation of synapse maturation (GO:0090129)2.02805791
170positive regulation of synaptic transmission, GABAergic (GO:0032230)2.02421241
171filopodium assembly (GO:0046847)2.02388230

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.36557449
2GBX2_23144817_ChIP-Seq_PC3_Human2.47437235
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39436503
4DROSHA_22980978_ChIP-Seq_HELA_Human2.37279027
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.28098378
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12202917
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04866214
8MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03973886
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03878662
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01546034
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01546034
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00723703
13JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97854546
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92463514
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83782824
16SMAD_19615063_ChIP-ChIP_OVARY_Human1.75950858
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.75492275
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.73969751
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71498589
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70791509
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.68853753
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.63537201
23REST_21632747_ChIP-Seq_MESCs_Mouse1.62305913
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.59529140
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.55094682
26* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54062921
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53690405
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50457675
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.48545989
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.48453807
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46109645
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44759824
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42715739
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40223441
35SOX2_20726797_ChIP-Seq_SW620_Human1.34054668
36CDX2_20551321_ChIP-Seq_CACO-2_Human1.32126179
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.31161148
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.30827195
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30503791
40AHR_22903824_ChIP-Seq_MCF-7_Human1.30050036
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29919911
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.23527189
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23184649
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.20724353
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18783480
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.18671091
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18174022
48* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17609851
49SMAD3_21741376_ChIP-Seq_HESCs_Human1.15919210
50TBX20_22080862_ChIP-Seq_HEART_Mouse1.15723662
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.15723662
52AR_21572438_ChIP-Seq_LNCaP_Human1.14869899
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13522786
54CLOCK_20551151_ChIP-Seq_293T_Human1.13144626
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.13016911
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12441083
57RXR_22108803_ChIP-Seq_LS180_Human1.12046675
58AR_25329375_ChIP-Seq_VCAP_Human1.11911800
59* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11863132
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11761496
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11126745
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10927727
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.10681076
64KDM2B_26808549_Chip-Seq_K562_Human1.10160047
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.08441102
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07780177
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07181907
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06762767
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06414275
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06253916
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.06057199
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06041693
73* STAT3_23295773_ChIP-Seq_U87_Human1.04968457
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04942147
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04742006
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.04474937
77LXR_22158963_ChIP-Seq_LIVER_Mouse1.04238885
78* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04002395
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03764250
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02507484
81* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01850496
82TP53_16413492_ChIP-PET_HCT116_Human1.01535891
83AR_19668381_ChIP-Seq_PC3_Human1.00704592
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00122436
85GATA4_25053715_ChIP-Seq_YYC3_Human0.98515813
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.97261916
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96521057
88* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96446734
89GATA1_26923725_Chip-Seq_HPCs_Mouse0.96344028
90ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95694383
91SMAD3_21741376_ChIP-Seq_EPCs_Human0.95322543
92BCAT_22108803_ChIP-Seq_LS180_Human0.95171152
93ESR1_20079471_ChIP-ChIP_T-47D_Human0.94732357
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94503195
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93749131
96* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93413408
97NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93289253
98RING1B_27294783_Chip-Seq_ESCs_Mouse0.92890026
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92875040
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92555887
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91710828
102* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90910680
103* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90848099
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90188379
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89666687
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89440815
107P300_19829295_ChIP-Seq_ESCs_Human0.87884430
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86487636
109TCF4_23295773_ChIP-Seq_U87_Human0.86075914
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.85714736
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.84978482
112CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84049594
113DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83955050
114* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83802640
115TP53_18474530_ChIP-ChIP_U2OS_Human0.82936473
116EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81160863
117FOXA2_19822575_ChIP-Seq_HepG2_Human0.80901294
118* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80639501
119* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80290750
120VDR_24787735_ChIP-Seq_THP-1_Human0.80173318
121TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78749706
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.78718681
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78507926
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.78034823
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77957386
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.77491793
127TCF4_18268006_ChIP-ChIP_LS174T_Human0.77352164
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.77210974
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76625563
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76384102
131KLF5_25053715_ChIP-Seq_YYC3_Human0.76202855
132P53_22127205_ChIP-Seq_FIBROBLAST_Human0.75317315
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.75198385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.51381641
2MP0002822_catalepsy3.56756280
3MP0002254_reproductive_system_inflammat3.02489613
4MP0003635_abnormal_synaptic_transmissio3.00847995
5MP0004782_abnormal_surfactant_physiolog2.96902286
6MP0003880_abnormal_central_pattern2.83968046
7MP0004270_analgesia2.79316675
8MP0010234_abnormal_vibrissa_follicle2.71014060
9MP0000566_synostosis2.70154124
10MP0004043_abnormal_pH_regulation2.57406235
11MP0002876_abnormal_thyroid_physiology2.55404718
12MP0009745_abnormal_behavioral_response2.54590271
13MP0001501_abnormal_sleep_pattern2.47438649
14MP0005409_darkened_coat_color2.42592280
15MP0010352_gastrointestinal_tract_polyps2.36179807
16MP0002063_abnormal_learning/memory/cond2.30678579
17MP0002064_seizures2.16864135
18MP0009379_abnormal_foot_pigmentation2.00360494
19MP0009780_abnormal_chondrocyte_physiolo1.97426328
20MP0003879_abnormal_hair_cell1.95604833
21MP0002909_abnormal_adrenal_gland1.95051905
22MP0009046_muscle_twitch1.94230752
23MP0001765_abnormal_ion_homeostasis1.92527261
24MP0003183_abnormal_peptide_metabolism1.90380310
25MP0004858_abnormal_nervous_system1.90261994
26MP0002139_abnormal_hepatobiliary_system1.87532503
27MP0005167_abnormal_blood-brain_barrier1.85259110
28MP0002572_abnormal_emotion/affect_behav1.84307685
29MP0001968_abnormal_touch/_nociception1.81970422
30MP0002735_abnormal_chemical_nociception1.81146647
31MP0003300_gastrointestinal_ulcer1.79042995
32MP0005310_abnormal_salivary_gland1.76718740
33MP0000579_abnormal_nail_morphology1.73155762
34MP0002272_abnormal_nervous_system1.71891848
35MP0008569_lethality_at_weaning1.69019476
36MP0002734_abnormal_mechanical_nocicepti1.68279086
37MP0001486_abnormal_startle_reflex1.67330753
38MP0001440_abnormal_grooming_behavior1.64435246
39MP0003136_yellow_coat_color1.61482294
40MP0008961_abnormal_basal_metabolism1.59158670
41MP0005248_abnormal_Harderian_gland1.58659163
42MP0003283_abnormal_digestive_organ1.57208768
43MP0003075_altered_response_to1.53915951
44MP0005085_abnormal_gallbladder_physiolo1.53498166
45MP0003868_abnormal_feces_composition1.52484496
46MP0005645_abnormal_hypothalamus_physiol1.47419697
47MP0010678_abnormal_skin_adnexa1.45606589
48MP0004885_abnormal_endolymph1.44479565
49MP0004510_myositis1.43833921
50MP0005623_abnormal_meninges_morphology1.43369489
51MP0005171_absent_coat_pigmentation1.42345473
52MP0003866_abnormal_defecation1.41240689
53MP0003329_amyloid_beta_deposits1.40609777
54MP0002733_abnormal_thermal_nociception1.39667903
55MP0010386_abnormal_urinary_bladder1.38205792
56MP0003045_fibrosis1.37254748
57MP0003690_abnormal_glial_cell1.34901459
58MP0001873_stomach_inflammation1.33805645
59MP0001666_abnormal_nutrient_absorption1.32959171
60MP0000569_abnormal_digit_pigmentation1.32724104
61MP0001664_abnormal_digestion1.32323377
62MP0005423_abnormal_somatic_nervous1.32117573
63MP0005535_abnormal_body_temperature1.31296056
64MP0002736_abnormal_nociception_after1.30558287
65MP0003633_abnormal_nervous_system1.29902282
66MP0001970_abnormal_pain_threshold1.29052264
67MP0002638_abnormal_pupillary_reflex1.29010702
68MP0002067_abnormal_sensory_capabilities1.26955581
69MP0004147_increased_porphyrin_level1.25892922
70MP0001502_abnormal_circadian_rhythm1.25072681
71MP0000477_abnormal_intestine_morphology1.20756213
72MP0001958_emphysema1.20619623
73MP0000920_abnormal_myelination1.19652231
74MP0003705_abnormal_hypodermis_morpholog1.19534009
75MP0005360_urolithiasis1.17586810
76MP0001348_abnormal_lacrimal_gland1.14617586
77MP0002138_abnormal_hepatobiliary_system1.14134587
78MP0003878_abnormal_ear_physiology1.13555203
79MP0005377_hearing/vestibular/ear_phenot1.13555203
80MP0004484_altered_response_of1.12346176
81MP0001177_atelectasis1.12270391
82MP0005365_abnormal_bile_salt1.10958679
83MP0009384_cardiac_valve_regurgitation1.07091355
84MP0002557_abnormal_social/conspecific_i1.06887954
85MP0000604_amyloidosis1.04205342
86MP0004130_abnormal_muscle_cell1.02370466
87MP0000762_abnormal_tongue_morphology1.02282483
88MP0001346_abnormal_lacrimal_gland1.01923979
89MP0004264_abnormal_extraembryonic_tissu1.01229454
90MP0000383_abnormal_hair_follicle1.00440419
91MP0003634_abnormal_glial_cell0.99219671
92MP0000537_abnormal_urethra_morphology0.99041783
93MP0001984_abnormal_olfaction0.98592781
94MP0002098_abnormal_vibrissa_morphology0.98427687
95MP0005666_abnormal_adipose_tissue0.96924680
96MP0005166_decreased_susceptibility_to0.96874857
97MP0005388_respiratory_system_phenotype0.96619437
98MP0002133_abnormal_respiratory_system0.96619437
99MP0004019_abnormal_vitamin_homeostasis0.96163125
100MP0003632_abnormal_nervous_system0.95226769
101MP0005386_behavior/neurological_phenoty0.93231452
102MP0004924_abnormal_behavior0.93231452
103MP0008872_abnormal_physiological_respon0.92611641
104MP0005670_abnormal_white_adipose0.91631078
105MP0002069_abnormal_eating/drinking_beha0.91280425
106MP0000751_myopathy0.90661365
107MP0003631_nervous_system_phenotype0.87660696
108MP0001663_abnormal_digestive_system0.85872183
109MP0003011_delayed_dark_adaptation0.85812919
110MP0002066_abnormal_motor_capabilities/c0.85479784
111MP0004811_abnormal_neuron_physiology0.84591900
112MP0005448_abnormal_energy_balance0.84486636
113MP0000538_abnormal_urinary_bladder0.81979404
114MP0005646_abnormal_pituitary_gland0.81707691
115MP0004185_abnormal_adipocyte_glucose0.80896466
116MP0002006_tumorigenesis0.80662591
117MP0000013_abnormal_adipose_tissue0.80654858
118MP0002896_abnormal_bone_mineralization0.80602654
119MP0000377_abnormal_hair_follicle0.80461249
120MP0009643_abnormal_urine_homeostasis0.79446542
121MP0001756_abnormal_urination0.78506555
122MP0005375_adipose_tissue_phenotype0.76999011
123MP0003172_abnormal_lysosome_physiology0.76524429
124MP0001188_hyperpigmentation0.76250528
125MP0000462_abnormal_digestive_system0.75874733
126MP0005165_increased_susceptibility_to0.75114056
127MP0004215_abnormal_myocardial_fiber0.75022176
128MP0000747_muscle_weakness0.74662433
129MP0003091_abnormal_cell_migration0.74192673
130MP0005381_digestive/alimentary_phenotyp0.74100981
131MP0000230_abnormal_systemic_arterial0.73222472
132MP0000026_abnormal_inner_ear0.73152852
133MP0005595_abnormal_vascular_smooth0.73074563
134MP0003787_abnormal_imprinting0.72591698
135MP0000778_abnormal_nervous_system0.72150441
136MP0000955_abnormal_spinal_cord0.72049801
137MP0002229_neurodegeneration0.71475777
138MP0002882_abnormal_neuron_morphology0.71371059
139MP0001485_abnormal_pinna_reflex0.70296654
140MP0008874_decreased_physiological_sensi0.69877776
141MP0010155_abnormal_intestine_physiology0.68843885
142MP0002136_abnormal_kidney_physiology0.67487303
143MP0005636_abnormal_mineral_homeostasis0.67096571
144MP0002971_abnormal_brown_adipose0.66859824
145MP0002693_abnormal_pancreas_physiology0.66688121

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)5.41141666
2Focal motor seizures (HP:0011153)5.25856163
3Increased circulating renin level (HP:0000848)4.92841989
4Metabolic alkalosis (HP:0200114)4.73688743
5Myokymia (HP:0002411)4.31768697
6Flat acetabular roof (HP:0003180)4.00686388
7Abnormality of chloride homeostasis (HP:0011422)3.94154073
8Abnormality of renin-angiotensin system (HP:0000847)3.85941865
9Decreased circulating renin level (HP:0003351)3.65403004
10Hyperaldosteronism (HP:0000859)3.64372664
11Focal seizures (HP:0007359)3.62123810
12Retinal atrophy (HP:0001105)3.52916049
13Visual hallucinations (HP:0002367)3.18130016
14Hypokalemic alkalosis (HP:0001949)3.12989050
15Hyponatremia (HP:0002902)3.11764142
16Hyperkalemia (HP:0002153)3.09989213
17Adrenal overactivity (HP:0002717)3.08814225
18Febrile seizures (HP:0002373)3.07086299
19Progressive cerebellar ataxia (HP:0002073)3.06388918
20Action tremor (HP:0002345)3.05096141
21Hypomagnesemia (HP:0002917)3.01376929
22Ventricular fibrillation (HP:0001663)3.00127046
23Supranuclear gaze palsy (HP:0000605)2.97606906
24Exercise-induced myalgia (HP:0003738)2.97103435
25Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.96209618
26Hydroxyprolinuria (HP:0003080)2.92048197
27Abnormality of proline metabolism (HP:0010907)2.92048197
28Epileptic encephalopathy (HP:0200134)2.86509617
29Abnormality of magnesium homeostasis (HP:0004921)2.83451029
30Neonatal short-limb short stature (HP:0008921)2.81742380
31Abnormal eating behavior (HP:0100738)2.79855048
32Visceral angiomatosis (HP:0100761)2.72207478
33Abnormality of potassium homeostasis (HP:0011042)2.71774276
34Abnormality of renal excretion (HP:0011036)2.67363243
35Abnormality of the distal phalanx of the thumb (HP:0009617)2.66433019
36Abnormality of calcium-phosphate metabolism (HP:0100530)2.60075589
37Cerebral inclusion bodies (HP:0100314)2.57390538
38Hyperphosphatemia (HP:0002905)2.57165564
39Hypercortisolism (HP:0001578)2.53255786
40Atonic seizures (HP:0010819)2.52091490
41Abnormal urine output (HP:0012590)2.51682431
42Hemangiomatosis (HP:0007461)2.50269257
43Abnormality of glutamine family amino acid metabolism (HP:0010902)2.48388401
44Postural instability (HP:0002172)2.45745235
45Dysmetria (HP:0001310)2.45739950
46Chronic bronchitis (HP:0004469)2.41974010
47Vertebral clefting (HP:0008428)2.39946911
48Gout (HP:0001997)2.39168838
49Polyuria (HP:0000103)2.37285578
50Gaze-evoked nystagmus (HP:0000640)2.36495353
51Pili torti (HP:0003777)2.36435198
52Absence seizures (HP:0002121)2.33300847
53Muscle fiber inclusion bodies (HP:0100299)2.32129893
54Cerebellar dysplasia (HP:0007033)2.32005567
55Hemiplegia (HP:0002301)2.30673708
56Generalized tonic-clonic seizures (HP:0002069)2.28068731
57Abnormality of the lower motor neuron (HP:0002366)2.27667880
58Dysdiadochokinesis (HP:0002075)2.27346334
59Hypokalemia (HP:0002900)2.26497297
60Abnormal drinking behavior (HP:0030082)2.25168316
61Polydipsia (HP:0001959)2.25168316
62Dialeptic seizures (HP:0011146)2.24025523
63Buphthalmos (HP:0000557)2.22394735
64Dysmetric saccades (HP:0000641)2.20893119
65Genetic anticipation (HP:0003743)2.18430939
66Renal salt wasting (HP:0000127)2.15640204
67Flattened epiphyses (HP:0003071)2.15211340
68Nemaline bodies (HP:0003798)2.14712766
69Tetany (HP:0001281)2.14295432
70Scanning speech (HP:0002168)2.13884001
71Hypoplasia of dental enamel (HP:0006297)2.11941331
72Alkalosis (HP:0001948)2.11639132
73Autoimmune thrombocytopenia (HP:0001973)2.11009160
74Bundle branch block (HP:0011710)2.10965450
75Truncal ataxia (HP:0002078)2.08573306
76Intention tremor (HP:0002080)2.08060742
77Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.07844757
78Hyperparathyroidism (HP:0000843)2.07332635
79Exercise-induced muscle cramps (HP:0003710)2.07100922
80Hemiparesis (HP:0001269)2.06475044
81Impaired smooth pursuit (HP:0007772)1.99928770
82Ileus (HP:0002595)1.97109181
83Split foot (HP:0001839)1.96501407
84Depression (HP:0000716)1.94258880
85Centrally nucleated skeletal muscle fibers (HP:0003687)1.93674195
86Conjunctival telangiectasia (HP:0000524)1.93541238
87Bronchomalacia (HP:0002780)1.91544077
88Amelogenesis imperfecta (HP:0000705)1.90381146
89Chronic diarrhea (HP:0002028)1.90349649
90Hypotension (HP:0002615)1.89985722
91Syncope (HP:0001279)1.89807473
92Difficulty climbing stairs (HP:0003551)1.88856085
93Increased purine levels (HP:0004368)1.88636707
94Hyperuricemia (HP:0002149)1.88636707
95Impaired social interactions (HP:0000735)1.87953680
96Abnormal social behavior (HP:0012433)1.87953680
97Muscle stiffness (HP:0003552)1.86255736
98Neurofibrillary tangles (HP:0002185)1.85603770
99Akinesia (HP:0002304)1.85537118
100Abdominal distention (HP:0003270)1.85020516
101Prolonged QT interval (HP:0001657)1.84331931
102Focal segmental glomerulosclerosis (HP:0000097)1.83373677
103Ankle clonus (HP:0011448)1.83142311
104Abnormality of purine metabolism (HP:0004352)1.81839016
105Spinal cord compression (HP:0002176)1.80862474
106Congenital sensorineural hearing impairment (HP:0008527)1.80541760
107Broad-based gait (HP:0002136)1.80345658
108Impaired vibration sensation in the lower limbs (HP:0002166)1.80310452
109Aplasia involving bones of the upper limbs (HP:0009823)1.80219232
110Aplasia of the phalanges of the hand (HP:0009802)1.80219232
111Aplasia involving bones of the extremities (HP:0009825)1.80219232
112Symptomatic seizures (HP:0011145)1.80164959
113Mucopolysacchariduria (HP:0008155)1.79254275
114Urinary glycosaminoglycan excretion (HP:0003541)1.79254275
115Difficulty running (HP:0009046)1.79091947
116Dehydration (HP:0001944)1.79087231
117Partial duplication of thumb phalanx (HP:0009944)1.78440340
118Increased IgE level (HP:0003212)1.77588882
119Amyotrophic lateral sclerosis (HP:0007354)1.77471708
120Papilledema (HP:0001085)1.77236076
121Segmental peripheral demyelination/remyelination (HP:0003481)1.77114433
122Interstitial pulmonary disease (HP:0006530)1.76459449
123Widely patent fontanelles and sutures (HP:0004492)1.75737251
124Confusion (HP:0001289)1.75568082
125Anxiety (HP:0000739)1.75412662
126Right ventricular cardiomyopathy (HP:0011663)1.75383838
127Cone-rod dystrophy (HP:0000548)1.74576247
128Hypercalciuria (HP:0002150)1.73845483
129Stereotypic behavior (HP:0000733)1.73642359
130Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73466765
131Abnormality of polysaccharide metabolism (HP:0011012)1.73466765
132Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73466765
133Urinary urgency (HP:0000012)1.72831639
134Spastic tetraparesis (HP:0001285)1.72788799
135Abnormal cartilage morphology (HP:0002763)1.71428198
136Excessive salivation (HP:0003781)1.71018326
137Drooling (HP:0002307)1.71018326
138Intrahepatic cholestasis (HP:0001406)1.70439713
139Dysostosis multiplex (HP:0000943)1.69693650
140Abnormality of sodium homeostasis (HP:0010931)1.69182555
141Abnormality of the gastric mucosa (HP:0004295)1.68422031
142Thickened helices (HP:0000391)1.67970091
143Hip contracture (HP:0003273)1.67301883
144Breech presentation (HP:0001623)1.66349257
145Conjugated hyperbilirubinemia (HP:0002908)1.66207441
146Abnormality of monocarboxylic acid metabolism (HP:0010996)1.65879234
147Rapidly progressive (HP:0003678)1.64230177
148Flat capital femoral epiphysis (HP:0003370)1.63900067
149Vertebral hypoplasia (HP:0008417)1.62920061
150Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.62920061
151Diplopia (HP:0000651)1.62580870
152Abnormality of binocular vision (HP:0011514)1.62580870
153Heart block (HP:0012722)1.61240346
154Hemorrhage of the eye (HP:0011885)1.61192058
155Large earlobe (HP:0009748)1.59800427
156Type II lissencephaly (HP:0007260)1.59053879
157Limited hip movement (HP:0008800)1.56818659
158Congenital glaucoma (HP:0001087)1.55138204
159Abnormality of the vasculature of the conjunctiva (HP:0008054)1.54251623
160Type 1 muscle fiber predominance (HP:0003803)1.53340720
161Abnormality of the dental root (HP:0006486)1.51523770
162Taurodontia (HP:0000679)1.51523770
163Abnormality of permanent molar morphology (HP:0011071)1.51523770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.62085668
2PIK3CA3.25079908
3EPHA43.21096215
4LMTK22.86840623
5MAP3K92.77025148
6TNIK2.32844548
7MAP3K22.30057248
8FRK2.22460022
9MET2.17140699
10EPHB22.07275616
11OBSCN2.06053182
12EPHA22.03907471
13CASK2.01413824
14WNK41.90960829
15PRKD31.88753414
16MAP3K41.86493425
17KSR21.83210682
18PDK21.82954635
19RIPK41.79601532
20MAP3K131.78739760
21RIPK11.77136282
22ACVR1B1.76374362
23DAPK21.72403495
24MST1R1.71195005
25OXSR11.60656799
26NEK61.59719952
27CAMKK11.55104902
28MAP3K71.50254517
29STK381.49843948
30WNK31.49128899
31MAP3K141.45606547
32NTRK21.42568699
33STK241.35937689
34MINK11.31354695
35MAP2K71.28303581
36FGFR41.27533029
37FGFR21.25715757
38WNK11.23928504
39SGK31.14998082
40PAK61.14633519
41CDK51.14470516
42FER1.12538593
43STK391.09956456
44MARK31.08278326
45FES1.08035919
46MAP3K11.07591275
47CAMKK21.02782279
48SGK21.02759885
49BCR1.02429867
50JAK11.01897896
51FGFR31.00743330
52PDK11.00092095
53NTRK10.96219799
54MAP2K40.95790687
55PDPK10.95737130
56SGK2230.95713094
57SGK4940.95713094
58EEF2K0.94916962
59NME10.94485348
60MARK20.91901135
61ERBB20.91883077
62EPHB10.91156442
63PDGFRA0.90873169
64NLK0.90630966
65UHMK10.90586162
66RET0.89981350
67TAOK10.89933847
68PRKCH0.89874442
69SGK10.89476462
70INSRR0.87806955
71CAMK10.87737644
72STK110.87204129
73PRPF4B0.86887346
74KSR10.85189562
75ICK0.84335541
76MAP3K120.84077979
77CDC42BPA0.83602301
78CAMK1G0.81004169
79DYRK1A0.79077393
80PTK60.78569779
81LATS20.78375459
82MARK10.77744972
83MAPK120.77606086
84STK100.76553768
85YES10.74354955
86BMX0.73397872
87CAMK2B0.73305804
88PRKAA20.72657713
89GRK50.72611521
90MST40.71939619
91JAK20.71272091
92PRKG20.70706235
93IRAK30.69473561
94STK38L0.68087762
95TYRO30.67344082
96CAMK1D0.66367954
97MAPK70.64354179
98EPHA30.63929418
99MAP2K20.61322385
100CAMK2A0.60399583
101DMPK0.59656507
102DAPK10.59445271
103MAP3K100.58467613
104DDR20.56495789
105RPS6KA20.56217725
106MAPK150.55973611
107SIK20.55351454
108TBK10.54036800
109TTN0.53658881
110PTK2B0.50616594
111PTK20.49889236
112MAP2K10.49660548
113MAP3K60.49623557
114SCYL20.49534374
115PRKCG0.49299415
116JAK30.48650362
117FYN0.46975647
118ALK0.45995508
119PRKCZ0.45993500
120IKBKE0.45670589
121CDK60.45432869
122ERBB30.44988912
123PRKCE0.44065575
124RPS6KA30.42478391
125CAMK2G0.42432274
126ARAF0.42301253
127PRKAA10.41926894
128PHKG20.40945764
129PHKG10.40945764
130TRIB30.40600156
131PRKACG0.40491331
132PAK30.40135723
133ROCK20.40132323
134PDGFRB0.39892074
135CAMK2D0.39881606
136LRRK20.39752478
137SRC0.39014472
138MAPK130.38967870
139PRKCQ0.38788124
140PINK10.38280767

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.34750657
2Histidine metabolism_Homo sapiens_hsa003402.34231063
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.33789221
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07817889
5Circadian entrainment_Homo sapiens_hsa047131.94741931
6Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.94404641
7Synaptic vesicle cycle_Homo sapiens_hsa047211.92703134
8Long-term potentiation_Homo sapiens_hsa047201.88997245
9Mineral absorption_Homo sapiens_hsa049781.84407024
10Cyanoamino acid metabolism_Homo sapiens_hsa004601.84072696
11Salivary secretion_Homo sapiens_hsa049701.83563837
12Gastric acid secretion_Homo sapiens_hsa049711.82471068
13Glutamatergic synapse_Homo sapiens_hsa047241.81905994
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81109540
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69175887
16GABAergic synapse_Homo sapiens_hsa047271.68518486
17Olfactory transduction_Homo sapiens_hsa047401.66754678
18Amphetamine addiction_Homo sapiens_hsa050311.63074357
19Insulin secretion_Homo sapiens_hsa049111.59908625
20Morphine addiction_Homo sapiens_hsa050321.56069035
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.44575916
22Nitrogen metabolism_Homo sapiens_hsa009101.44033107
23Fatty acid degradation_Homo sapiens_hsa000711.42850417
24Arginine biosynthesis_Homo sapiens_hsa002201.39229511
25Type II diabetes mellitus_Homo sapiens_hsa049301.37867795
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35663929
27Renin secretion_Homo sapiens_hsa049241.33270174
28Cholinergic synapse_Homo sapiens_hsa047251.31111521
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27908387
30Pancreatic secretion_Homo sapiens_hsa049721.25977986
31Arginine and proline metabolism_Homo sapiens_hsa003301.25776718
32Dopaminergic synapse_Homo sapiens_hsa047281.22597230
33Cocaine addiction_Homo sapiens_hsa050301.22502982
34Tight junction_Homo sapiens_hsa045301.21859687
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19188478
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16374003
37Bile secretion_Homo sapiens_hsa049761.15995986
38Taste transduction_Homo sapiens_hsa047421.14600668
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12417180
40Long-term depression_Homo sapiens_hsa047301.11461425
41cAMP signaling pathway_Homo sapiens_hsa040241.09588867
42GnRH signaling pathway_Homo sapiens_hsa049121.09334827
43Calcium signaling pathway_Homo sapiens_hsa040201.07804802
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07706763
45Type I diabetes mellitus_Homo sapiens_hsa049401.07166052
46Oxytocin signaling pathway_Homo sapiens_hsa049211.03993426
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03552493
48Collecting duct acid secretion_Homo sapiens_hsa049661.00393588
49Starch and sucrose metabolism_Homo sapiens_hsa005001.00234490
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98444898
51Thyroid hormone synthesis_Homo sapiens_hsa049180.95678320
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95642976
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94368383
54Sulfur metabolism_Homo sapiens_hsa009200.94310792
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93369098
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91025444
57Retinol metabolism_Homo sapiens_hsa008300.90427521
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88595170
59Dorso-ventral axis formation_Homo sapiens_hsa043200.87953913
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87781121
61Fatty acid biosynthesis_Homo sapiens_hsa000610.86393587
62Fat digestion and absorption_Homo sapiens_hsa049750.85576189
63Adherens junction_Homo sapiens_hsa045200.84504307
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83227509
65Caffeine metabolism_Homo sapiens_hsa002320.82285944
66Serotonergic synapse_Homo sapiens_hsa047260.81869701
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81580171
68Renin-angiotensin system_Homo sapiens_hsa046140.79601518
69Inositol phosphate metabolism_Homo sapiens_hsa005620.78593449
70beta-Alanine metabolism_Homo sapiens_hsa004100.78111389
71Glycerolipid metabolism_Homo sapiens_hsa005610.78107391
72Estrogen signaling pathway_Homo sapiens_hsa049150.78019845
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76965728
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.74759797
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.74462111
76Choline metabolism in cancer_Homo sapiens_hsa052310.74125356
77Protein digestion and absorption_Homo sapiens_hsa049740.73042701
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71863523
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71006367
80Vibrio cholerae infection_Homo sapiens_hsa051100.70287099
81Vitamin digestion and absorption_Homo sapiens_hsa049770.68765576
82Circadian rhythm_Homo sapiens_hsa047100.68516856
83African trypanosomiasis_Homo sapiens_hsa051430.68217795
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.67278634
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67195202
86ABC transporters_Homo sapiens_hsa020100.65877706
87ErbB signaling pathway_Homo sapiens_hsa040120.65645192
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.65031744
89Chemical carcinogenesis_Homo sapiens_hsa052040.64196323
90Glioma_Homo sapiens_hsa052140.63302769
91Tyrosine metabolism_Homo sapiens_hsa003500.63184162
92Gap junction_Homo sapiens_hsa045400.61884163
93Fatty acid metabolism_Homo sapiens_hsa012120.61372255
94Dilated cardiomyopathy_Homo sapiens_hsa054140.60727784
95Phenylalanine metabolism_Homo sapiens_hsa003600.58731789
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.56865377
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56858016
98Chemokine signaling pathway_Homo sapiens_hsa040620.54183816
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53186268
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52529718
101Osteoclast differentiation_Homo sapiens_hsa043800.52480613
102Graft-versus-host disease_Homo sapiens_hsa053320.52424444
103Insulin signaling pathway_Homo sapiens_hsa049100.52316983
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51431354
105Tuberculosis_Homo sapiens_hsa051520.50749492
106PPAR signaling pathway_Homo sapiens_hsa033200.50060213
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49790151
108Propanoate metabolism_Homo sapiens_hsa006400.49648713
109Endometrial cancer_Homo sapiens_hsa052130.49545291
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49455083
111Melanogenesis_Homo sapiens_hsa049160.48873441
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48520266
113Tryptophan metabolism_Homo sapiens_hsa003800.47901881
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.47370268
115MAPK signaling pathway_Homo sapiens_hsa040100.46784757
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.46762113
117VEGF signaling pathway_Homo sapiens_hsa043700.45669310
118AMPK signaling pathway_Homo sapiens_hsa041520.45502993
119Sphingolipid metabolism_Homo sapiens_hsa006000.45499374
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45321833
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44216099
122Salmonella infection_Homo sapiens_hsa051320.44102058
123Notch signaling pathway_Homo sapiens_hsa043300.43154192
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42738850
125Axon guidance_Homo sapiens_hsa043600.42127209
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40134281
127Prolactin signaling pathway_Homo sapiens_hsa049170.40127580
128TNF signaling pathway_Homo sapiens_hsa046680.39860073
129Endocytosis_Homo sapiens_hsa041440.39790355
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39564047
131Insulin resistance_Homo sapiens_hsa049310.39244314
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38180696
133Rheumatoid arthritis_Homo sapiens_hsa053230.37618316
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37433955
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35969657
136Rap1 signaling pathway_Homo sapiens_hsa040150.35969519
137Glucagon signaling pathway_Homo sapiens_hsa049220.35387722
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34890732
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.34805861

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