ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	7.99655625
2	homocysteine metabolic process (GO:0050667)	6.88118764
3	regulation of penile erection (GO:0060405)	6.85504530
4	regulation of plasminogen activation (GO:0010755)	6.75859769
5	folic acid-containing compound biosynthetic process (GO:0009396)	6.55239450
6	primary amino compound metabolic process (GO:1901160)	6.10040627
7	white fat cell differentiation (GO:0050872)	5.51904725
8	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.43666801
9	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.43666801
10	sulfur amino acid catabolic process (GO:0000098)	5.35455760
11	alternative mRNA splicing, via spliceosome (GO:0000380)	5.25967060
12	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	5.16060801
13	cysteine metabolic process (GO:0006534)	5.10738691
14	microtubule nucleation (GO:0007020)	4.98474505
15	negative regulation of DNA biosynthetic process (GO:2000279)	4.86101309
16	pyrimidine nucleobase catabolic process (GO:0006208)	4.61596883
17	rRNA methylation (GO:0031167)	4.56535846
18	pteridine-containing compound biosynthetic process (GO:0042559)	4.47048330
19	cerebral cortex radially oriented cell migration (GO:0021799)	4.45846830
20	DNA ligation (GO:0006266)	4.36267851
21	galactose catabolic process (GO:0019388)	4.34497692
22	adenosine metabolic process (GO:0046085)	4.31304330
23	cartilage morphogenesis (GO:0060536)	4.27970453
24	desmosome organization (GO:0002934)	4.20590776
25	limb bud formation (GO:0060174)	4.20088997
26	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	4.13293032
27	mitochondrial RNA metabolic process (GO:0000959)	4.08683776
28	indole-containing compound metabolic process (GO:0042430)	4.07762595
29	protein-chromophore linkage (GO:0018298)	4.02616236
30	serotonin metabolic process (GO:0042428)	3.96766247
31	indolalkylamine metabolic process (GO:0006586)	3.94702554
32	cochlea development (GO:0090102)	3.89634560
33	cardiac right ventricle morphogenesis (GO:0003215)	3.84433181
34	indole-containing compound catabolic process (GO:0042436)	3.82995899
35	indolalkylamine catabolic process (GO:0046218)	3.82995899
36	tryptophan catabolic process (GO:0006569)	3.82995899
37	nucleobase catabolic process (GO:0046113)	3.79806224
38	histone H4-K12 acetylation (GO:0043983)	3.74901453
39	rRNA modification (GO:0000154)	3.74883311
40	behavioral defense response (GO:0002209)	3.74051079
41	behavioral fear response (GO:0001662)	3.74051079
42	positive regulation of endothelial cell differentiation (GO:0045603)	3.70726450
43	L-serine metabolic process (GO:0006563)	3.70093045
44	pathway-restricted SMAD protein phosphorylation (GO:0060389)	3.64099028
45	negative regulation of keratinocyte proliferation (GO:0010839)	3.59496803
46	inner ear receptor cell development (GO:0060119)	3.53297972
47	regulation of sarcomere organization (GO:0060297)	3.51389642
48	sympathetic nervous system development (GO:0048485)	3.50523975
49	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	3.47351645
50	negative regulation of DNA recombination (GO:0045910)	3.47313611
51	kynurenine metabolic process (GO:0070189)	3.45692970
52	fear response (GO:0042596)	3.45683786
53	sulfur amino acid biosynthetic process (GO:0000097)	3.42543801
54	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	3.41571046
55	reciprocal DNA recombination (GO:0035825)	3.41285853
56	reciprocal meiotic recombination (GO:0007131)	3.41285853
57	mRNA splice site selection (GO:0006376)	3.40738508
58	purine nucleotide salvage (GO:0032261)	3.38344178
59	protein-cofactor linkage (GO:0018065)	3.26107965
60	negative regulation of catenin import into nucleus (GO:0035414)	3.24737871
61	regulation of sequestering of triglyceride (GO:0010889)	3.20256207
62	cell migration involved in heart development (GO:0060973)	3.19662744
63	behavioral response to ethanol (GO:0048149)	3.17680459
64	cardiac ventricle formation (GO:0003211)	3.17110557
65	lymphangiogenesis (GO:0001946)	3.16877371
66	neural crest cell development (GO:0014032)	3.15928668
67	negative regulation of chondrocyte differentiation (GO:0032331)	3.13046381
68	galactose metabolic process (GO:0006012)	3.13002889
69	regulation of tight junction assembly (GO:2000810)	3.12632026
70	positive regulation of peptidyl-lysine acetylation (GO:2000758)	3.11565772
71	positive regulation of protein acetylation (GO:1901985)	3.11565772
72	aminoglycoside antibiotic metabolic process (GO:0030647)	3.10401448
73	folic acid-containing compound metabolic process (GO:0006760)	3.08371191
74	negative regulation of epidermal cell differentiation (GO:0045605)	3.07681468
75	serine family amino acid biosynthetic process (GO:0009070)	3.06729021
76	regulation of vitamin D biosynthetic process (GO:0060556)	3.03385329
77	response to lipoprotein particle (GO:0055094)	3.01061393
78	regulation of gonadotropin secretion (GO:0032276)	2.98065716
79	monoamine transport (GO:0015844)	2.96044528
80	tetrahydrofolate metabolic process (GO:0046653)	2.94907268
81	serine family amino acid catabolic process (GO:0009071)	2.93077088
82	tryptophan metabolic process (GO:0006568)	2.92238250
83	negative regulation of Ras GTPase activity (GO:0034261)	2.90456387
84	activin receptor signaling pathway (GO:0032924)	2.88849631
85	negative regulation of telomerase activity (GO:0051974)	2.87531419
86	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.87389595
87	cardiac chamber formation (GO:0003207)	2.85261942
88	cerebral cortex cell migration (GO:0021795)	2.82407159
89	innervation (GO:0060384)	2.75968535
90	spinal cord development (GO:0021510)	2.75661927
91	tRNA modification (GO:0006400)	2.75613485
92	response to vitamin A (GO:0033189)	2.75127070
93	keratinocyte development (GO:0003334)	2.74768926
94	mesenchymal cell development (GO:0014031)	2.74137311
95	thalamus development (GO:0021794)	2.73475761
96	neuronal action potential propagation (GO:0019227)	2.73045332
97	positive regulation of histone acetylation (GO:0035066)	2.70783988
98	regulation of endothelial cell differentiation (GO:0045601)	2.69692870
99	behavioral response to nicotine (GO:0035095)	2.67548339
100	muscle atrophy (GO:0014889)	2.66726595

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.69989840
2	VDR_22108803_ChIP-Seq_LS180_Human	3.86364901
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.10305706
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.73957281
5	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.73775746
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.61287914
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.47139244
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.41367840
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.27107637
10	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.12746881
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.03651880
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.01278835
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	12.2526281
14	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.95034561
15	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.93871669
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.83639087
17	P300_19829295_ChIP-Seq_ESCs_Human	1.82856816
18	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.74268323
19	E2F7_22180533_ChIP-Seq_HELA_Human	1.74239023
20	EWS_26573619_Chip-Seq_HEK293_Human	1.67378520
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.65522136
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.53562409
23	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.53299971
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.48776788
25	FUS_26573619_Chip-Seq_HEK293_Human	1.47488196
26	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.46956762
27	EZH2_22144423_ChIP-Seq_EOC_Human	1.46542266
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39547241
29	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.38569741
30	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.38569741
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.35061987
32	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.33702426
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.32973054
34	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.31078873
35	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.30267083
36	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.30093862
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.28692956
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.28408107
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26771989
40	STAT3_23295773_ChIP-Seq_U87_Human	1.26282921
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.25871418
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22032263
43	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21502855
44	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.20384348
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20132071
46	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.18993766
47	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.17583330
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.17581352
49	CDX2_22108803_ChIP-Seq_LS180_Human	1.17544549
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16402253
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15732232
52	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15497004
53	NCOR_22424771_ChIP-Seq_293T_Human	1.15108475
54	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14593891
55	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14172053
56	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.13805224
57	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.11643628
58	SMAD4_21799915_ChIP-Seq_A2780_Human	1.09846931
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.06764079
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.05955442
61	DROSHA_22980978_ChIP-Seq_HELA_Human	1.05784174
62	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.05185382
63	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04510763
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03605569
65	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.02739228
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.01163958
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00116671
68	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99489485
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99155902
70	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.98288926
71	AHR_22903824_ChIP-Seq_MCF-7_Human	0.98035189
72	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.97094205
73	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.96598053
74	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.96525762
75	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.96248701
76	RXR_22108803_ChIP-Seq_LS180_Human	0.96081585
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.95740134
78	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94842705
79	ER_23166858_ChIP-Seq_MCF-7_Human	0.94651242
80	KDM2B_26808549_Chip-Seq_REH_Human	0.94639908
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.94212490
82	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.94098507
83	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.93610851
84	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.93043092
85	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.92433793
86	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.91324596
87	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.91295327
88	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.89925317
89	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.89084103
90	CBP_20019798_ChIP-Seq_JUKART_Human	0.89084103
91	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.88772944
92	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.88184627
93	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.88089126
94	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.87991418
95	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.86916899
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.86859306
97	TCF4_23295773_ChIP-Seq_U87_Human	0.86108598
98	AR_25329375_ChIP-Seq_VCAP_Human	0.86077787
99	JUN_21703547_ChIP-Seq_K562_Human	0.86014935
100	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.85945798

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	4.14018591
2	MP0000516_abnormal_urinary_system	3.78512739
3	MP0005367_renal/urinary_system_phenotyp	3.78512739
4	MP0005646_abnormal_pituitary_gland	3.69611707
5	MP0002736_abnormal_nociception_after	3.24538698
6	MP0005670_abnormal_white_adipose	3.21837049
7	MP0008995_early_reproductive_senescence	3.12343047
8	MP0002938_white_spotting	3.02097562
9	MP0000566_synostosis	2.66007115
10	MP0004885_abnormal_endolymph	2.52895104
11	MP0000013_abnormal_adipose_tissue	2.41103733
12	MP0001968_abnormal_touch/_nociception	2.28439629
13	MP0003705_abnormal_hypodermis_morpholog	2.21658057
14	MP0001661_extended_life_span	2.21388062
15	MP0004185_abnormal_adipocyte_glucose	2.18978244
16	MP0005647_abnormal_sex_gland	2.08785202
17	MP0003724_increased_susceptibility_to	2.01190714
18	MP0006276_abnormal_autonomic_nervous	1.96794171
19	MP0002751_abnormal_autonomic_nervous	1.94815765
20	MP0002095_abnormal_skin_pigmentation	1.77581191
21	MP0008775_abnormal_heart_ventricle	1.75249365
22	MP0002735_abnormal_chemical_nociception	1.73330445
23	MP0000534_abnormal_ureter_morphology	1.69880266
24	MP0001501_abnormal_sleep_pattern	1.69433975
25	MP0003942_abnormal_urinary_system	1.67722911
26	MP0004147_increased_porphyrin_level	1.67610740
27	MP0000647_abnormal_sebaceous_gland	1.66606828
28	MP0005253_abnormal_eye_physiology	1.62180943
29	MP0004130_abnormal_muscle_cell	1.59830115
30	MP0002572_abnormal_emotion/affect_behav	1.52302907
31	MP0002282_abnormal_trachea_morphology	1.45634199
32	MP0002184_abnormal_innervation	1.43975466
33	MP0010030_abnormal_orbit_morphology	1.39859158
34	MP0004043_abnormal_pH_regulation	1.37795477
35	MP0000579_abnormal_nail_morphology	1.34327353
36	MP0008872_abnormal_physiological_respon	1.33698378
37	MP0001764_abnormal_homeostasis	1.33198938
38	MP0009697_abnormal_copulation	1.30016539
39	MP0000538_abnormal_urinary_bladder	1.27915586
40	MP0002733_abnormal_thermal_nociception	1.25165183
41	MP0002396_abnormal_hematopoietic_system	1.24705033
42	MP0003938_abnormal_ear_development	1.24234912
43	MP0000569_abnormal_digit_pigmentation	1.21865590
44	MP0006292_abnormal_olfactory_placode	1.18817191
45	MP0002139_abnormal_hepatobiliary_system	1.18413680
46	MP0004134_abnormal_chest_morphology	1.18374951
47	MP0000049_abnormal_middle_ear	1.17752938
48	MP0009745_abnormal_behavioral_response	1.17326836
49	MP0000631_abnormal_neuroendocrine_gland	1.13847723
50	MP0010368_abnormal_lymphatic_system	1.07263961
51	MP0000681_abnormal_thyroid_gland	1.04643059
52	MP0002063_abnormal_learning/memory/cond	1.02417550
53	MP0000026_abnormal_inner_ear	1.01489277
54	MP0002638_abnormal_pupillary_reflex	1.01308123
55	MP0002160_abnormal_reproductive_system	1.01217352
56	MP0005332_abnormal_amino_acid	0.98077068
57	MP0003937_abnormal_limbs/digits/tail_de	0.96445940
58	MP0000003_abnormal_adipose_tissue	0.95304224
59	MP0008058_abnormal_DNA_repair	0.95278680
60	MP0000537_abnormal_urethra_morphology	0.94435909
61	MP0002069_abnormal_eating/drinking_beha	0.92844133
62	MP0004742_abnormal_vestibular_system	0.89809484
63	MP0004145_abnormal_muscle_electrophysio	0.89145162
64	MP0003890_abnormal_embryonic-extraembry	0.88202269
65	MP0005365_abnormal_bile_salt	0.87080550
66	MP0002138_abnormal_hepatobiliary_system	0.87070981
67	MP0003718_maternal_effect	0.83403621
68	MP0001340_abnormal_eyelid_morphology	0.83324804
69	MP0003786_premature_aging	0.83081698
70	MP0003315_abnormal_perineum_morphology	0.82582060
71	MP0002108_abnormal_muscle_morphology	0.81898925
72	MP0003635_abnormal_synaptic_transmissio	0.80686142
73	MP0001299_abnormal_eye_distance/	0.79717249
74	MP0002822_catalepsy	0.79560314
75	MP0002697_abnormal_eye_size	0.79363950
76	MP0009250_abnormal_appendicular_skeleto	0.78273314
77	MP0002272_abnormal_nervous_system	0.76267200
78	MP0010094_abnormal_chromosome_stability	0.76187538
79	MP0005551_abnormal_eye_electrophysiolog	0.75838932
80	MP0002653_abnormal_ependyma_morphology	0.73448026
81	MP0000383_abnormal_hair_follicle	0.73285932
82	MP0005085_abnormal_gallbladder_physiolo	0.73183388
83	MP0002210_abnormal_sex_determination	0.71771643
84	MP0000653_abnormal_sex_gland	0.70289721
85	MP0000778_abnormal_nervous_system	0.69456090
86	MP0003880_abnormal_central_pattern	0.67700098
87	MP0002127_abnormal_cardiovascular_syste	0.67579903
88	MP0004133_heterotaxia	0.65840510
89	MP0002102_abnormal_ear_morphology	0.64626343
90	MP0001944_abnormal_pancreas_morphology	0.64539447
91	MP0001485_abnormal_pinna_reflex	0.64088693
92	MP0000371_diluted_coat_color	0.63533054
93	MP0003186_abnormal_redox_activity	0.63461577
94	MP0001145_abnormal_male_reproductive	0.62495991
95	MP0003936_abnormal_reproductive_system	0.62178603
96	MP0000762_abnormal_tongue_morphology	0.61283763
97	MP0001963_abnormal_hearing_physiology	0.60948535
98	MP0000467_abnormal_esophagus_morphology	0.60093341
99	MP0003698_abnormal_male_reproductive	0.59191262
100	MP0005391_vision/eye_phenotype	0.58824797

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	7.03515380
2	Abnormality of alanine metabolism (HP:0010916)	7.03515380
3	Hyperalaninemia (HP:0003348)	7.03515380
4	Congenital sensorineural hearing impairment (HP:0008527)	5.46746960
5	Constricted visual fields (HP:0001133)	4.62889106
6	Hyperventilation (HP:0002883)	3.92143299
7	Pendular nystagmus (HP:0012043)	3.90398501
8	Homocystinuria (HP:0002156)	3.66560009
9	Abnormality of homocysteine metabolism (HP:0010919)	3.66560009
10	Esophageal varix (HP:0002040)	3.66213400
11	Heterochromia iridis (HP:0001100)	3.65116518
12	White forelock (HP:0002211)	3.51307177
13	Birth length less than 3rd percentile (HP:0003561)	3.44164262
14	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.31609300
15	Spontaneous hematomas (HP:0007420)	3.19057199
16	Cone-rod dystrophy (HP:0000548)	3.18309117
17	Small hand (HP:0200055)	3.17888674
18	Abnormality of the fetal cardiovascular system (HP:0010948)	3.16602534
19	Abnormal umbilical cord blood vessels (HP:0011403)	3.16602534
20	Single umbilical artery (HP:0001195)	3.16602534
21	Patchy hypopigmentation of hair (HP:0011365)	3.13660742
22	Absent speech (HP:0001344)	3.10148760
23	Chorioretinal atrophy (HP:0000533)	3.10077979
24	Ectopic kidney (HP:0000086)	2.93636384
25	Keratoconus (HP:0000563)	2.85345943
26	Increased corneal curvature (HP:0100692)	2.85345943
27	Conjunctival telangiectasia (HP:0000524)	2.81825030
28	Decreased subcutaneous fat (HP:0001002)	2.71765280
29	Toxemia of pregnancy (HP:0100603)	2.70351871
30	Hypoalphalipoproteinemia (HP:0003233)	2.68237188
31	Abnormality of the carotid arteries (HP:0005344)	2.66881862
32	Oligomenorrhea (HP:0000876)	2.63364983
33	Anorexia (HP:0002039)	2.53013340
34	Maternal diabetes (HP:0009800)	2.52158282
35	Hypothermia (HP:0002045)	2.51200822
36	Abnormality of serum amino acid levels (HP:0003112)	2.50054000
37	Stenosis of the external auditory canal (HP:0000402)	2.46223934
38	Chronic hepatic failure (HP:0100626)	2.41813022
39	Conjugated hyperbilirubinemia (HP:0002908)	2.41637380
40	Submucous cleft hard palate (HP:0000176)	2.41038754
41	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.38021680
42	Myocardial infarction (HP:0001658)	2.36715184
43	Arteriovenous malformation (HP:0100026)	2.35455292
44	Aplasia/Hypoplasia of the patella (HP:0006498)	2.35142902
45	Atonic seizures (HP:0010819)	2.34981217
46	Abnormality of the labia minora (HP:0012880)	2.33006152
47	Abnormality of DNA repair (HP:0003254)	2.32779569
48	Attenuation of retinal blood vessels (HP:0007843)	2.31805456
49	Polygenic inheritance (HP:0010982)	2.31683724
50	Action tremor (HP:0002345)	2.30804180
51	Visceral angiomatosis (HP:0100761)	2.26055212
52	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.24845624
53	Abolished electroretinogram (ERG) (HP:0000550)	2.22991228
54	Patellar aplasia (HP:0006443)	2.22406679
55	Fatigue (HP:0012378)	2.19781718
56	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.12971066
57	Short 1st metacarpal (HP:0010034)	2.12971066
58	Febrile seizures (HP:0002373)	2.10237805
59	Esophageal atresia (HP:0002032)	2.09319280
60	Concave nail (HP:0001598)	2.05654542
61	Epidermoid cyst (HP:0200040)	2.04685023
62	Chronic otitis media (HP:0000389)	2.03781533
63	Abnormality of subcutaneous fat tissue (HP:0001001)	2.01051614
64	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.99577334
65	Hemangiomatosis (HP:0007461)	1.98694047
66	Hypolipoproteinemia (HP:0010981)	1.92088830
67	Spontaneous abortion (HP:0005268)	1.91913698
68	True hermaphroditism (HP:0010459)	1.90795824
69	Exotropia (HP:0000577)	1.89859791
70	Bile duct proliferation (HP:0001408)	1.89418888
71	Abnormal biliary tract physiology (HP:0012439)	1.89418888
72	Hypopigmentation of the fundus (HP:0007894)	1.86570161
73	Duplicated collecting system (HP:0000081)	1.85618354
74	Limb dystonia (HP:0002451)	1.83715105
75	Pulmonary embolism (HP:0002204)	1.83314856
76	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.83247377
77	Abnormality of the 1st metacarpal (HP:0010009)	1.82648775
78	Insulin-resistant diabetes mellitus (HP:0000831)	1.77956985
79	Abnormality of the umbilical cord (HP:0010881)	1.77429600
80	Abnormality of incisor morphology (HP:0011063)	1.77311565
81	Abnormality of the renal collecting system (HP:0004742)	1.75456019
82	Abnormal number of incisors (HP:0011064)	1.75433151
83	Large earlobe (HP:0009748)	1.72138138
84	Midline defect of the nose (HP:0004122)	1.71817784
85	Obsessive-compulsive behavior (HP:0000722)	1.71528295
86	Septate vagina (HP:0001153)	1.70529518
87	Coronal craniosynostosis (HP:0004440)	1.64783683
88	Absent thumb (HP:0009777)	1.62618743
89	Chromsome breakage (HP:0040012)	1.61452530
90	Short hallux (HP:0010109)	1.60654596
91	Cutaneous finger syndactyly (HP:0010554)	1.60632091
92	Dyskinesia (HP:0100660)	1.60290406
93	Chorioretinal coloboma (HP:0000567)	1.59542444
94	Thyroiditis (HP:0100646)	1.58512615
95	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.58222052
96	Hypoplastic iliac wings (HP:0002866)	1.57791565
97	Hyperuricemia (HP:0002149)	1.57274815
98	Increased purine levels (HP:0004368)	1.57274815
99	Biconcave vertebral bodies (HP:0004586)	1.57201876
100	Poor speech (HP:0002465)	1.57116851

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CCNB1	7.08556141
2	ACVR1B	5.38275336
3	BMPR1B	3.41975411
4	FRK	2.97770398
5	CASK	2.62708408
6	EPHB2	2.53003695
7	CDK9	2.52012696
8	MAP2K3	2.50917768
9	NTRK3	2.36998141
10	MAP3K3	2.29700913
11	FGFR2	2.20087068
12	RPS6KB2	2.09352575
13	TGFBR2	1.94322125
14	NEK6	1.79893077
15	DYRK2	1.76015920
16	IRAK2	1.73666767
17	TAF1	1.70192005
18	WNK3	1.67403804
19	YES1	1.64221253
20	NTRK2	1.62344477
21	PIK3CA	1.57264625
22	MKNK2	1.50243992
23	VRK2	1.40519386
24	JAK3	1.40138925
25	MARK1	1.39403273
26	MAP2K1	1.38693732
27	FGR	1.33547307
28	STK39	1.30057299
29	SGK223	1.25119429
30	SGK494	1.25119429
31	OXSR1	1.20959931
32	PNCK	1.15859336
33	SGK2	1.13418378
34	TGFBR1	1.12690040
35	MAPK13	1.11894840
36	PLK2	1.07512320
37	ADRBK1	1.02374173
38	ERBB4	0.89680772
39	GRK1	0.89266383
40	BRD4	0.88719394
41	NEK9	0.87495330
42	PRKCE	0.84137270
43	CAMK1	0.79288817
44	CDK5	0.74651124
45	TAOK3	0.74402791
46	PHKG2	0.72878646
47	PHKG1	0.72878646
48	CAMK1G	0.67877099
49	PLK1	0.66784127
50	ADRBK2	0.65809681
51	SGK3	0.63793600
52	PRKCI	0.61045111
53	PAK4	0.60198599
54	CLK1	0.59867821
55	CAMK1D	0.59697242
56	SMG1	0.58560337
57	CSNK1G1	0.55876797
58	IRAK1	0.54802512
59	CAMK2A	0.53942156
60	ATR	0.53672369
61	SGK1	0.53185628
62	RPS6KB1	0.52963492
63	PTK6	0.52798998
64	LMTK2	0.52777157
65	UHMK1	0.52746884
66	KSR1	0.52509007
67	AURKA	0.51903470
68	TLK1	0.51093183
69	MKNK1	0.46513045
70	PINK1	0.46454965
71	CSNK1G3	0.46243049
72	CSNK1A1	0.44619906
73	GSK3A	0.44134078
74	MINK1	0.43960513
75	CDK6	0.43405880
76	PRKCG	0.40880024
77	DAPK1	0.40335332
78	WEE1	0.39109414
79	ERBB3	0.38897992
80	MELK	0.36964113
81	CAMKK2	0.35755041
82	SCYL2	0.35628548
83	CAMK2B	0.33472486
84	STK11	0.32466771
85	CDC7	0.32391703
86	CSNK1G2	0.32274967
87	EPHA2	0.31809742
88	PRKAA1	0.31782084
89	CDK2	0.31573737
90	CDK7	0.30647621
91	ROCK1	0.30580467
92	NUAK1	0.29687385
93	TNIK	0.29401687
94	PLK3	0.29210169
95	ATM	0.28036583
96	HIPK2	0.27830922
97	MAPK8	0.27690324
98	PRKG1	0.25785109
99	MAPK4	0.25248274
100	PRKDC	0.24356179

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Arginine biosynthesis_Homo sapiens_hsa00220	3.76285147
2	One carbon pool by folate_Homo sapiens_hsa00670	3.12007853
3	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.65657495
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.63723050
5	Collecting duct acid secretion_Homo sapiens_hsa04966	2.49613564
6	Tryptophan metabolism_Homo sapiens_hsa00380	2.37936259
7	Serotonergic synapse_Homo sapiens_hsa04726	2.34084281
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.22125725
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.19969125
10	Nicotine addiction_Homo sapiens_hsa05033	2.15925734
11	Sulfur metabolism_Homo sapiens_hsa00920	2.13533797
12	Sulfur relay system_Homo sapiens_hsa04122	2.09663452
13	GABAergic synapse_Homo sapiens_hsa04727	2.08915881
14	Phenylalanine metabolism_Homo sapiens_hsa00360	2.08000553
15	Morphine addiction_Homo sapiens_hsa05032	2.03574794
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.96814373
17	Retinol metabolism_Homo sapiens_hsa00830	1.94716999
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.90028544
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.89431545
20	Homologous recombination_Homo sapiens_hsa03440	1.84770652
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.80432048
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.79394048
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.77530979
24	Mismatch repair_Homo sapiens_hsa03430	1.69621606
25	Regulation of autophagy_Homo sapiens_hsa04140	1.69425234
26	Taste transduction_Homo sapiens_hsa04742	1.68312965
27	Glutamatergic synapse_Homo sapiens_hsa04724	1.58972271
28	Caffeine metabolism_Homo sapiens_hsa00232	1.54380034
29	Base excision repair_Homo sapiens_hsa03410	1.51228423
30	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.48310143
31	Butanoate metabolism_Homo sapiens_hsa00650	1.44532375
32	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.41791520
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.40496545
34	Folate biosynthesis_Homo sapiens_hsa00790	1.40256856
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38426652
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.30626964
37	Dopaminergic synapse_Homo sapiens_hsa04728	1.30297193
38	Circadian entrainment_Homo sapiens_hsa04713	1.28817146
39	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.27059969
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.26548410
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.22862324
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.14770243
43	Histidine metabolism_Homo sapiens_hsa00340	1.13295933
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.09110020
45	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.04555843
46	Propanoate metabolism_Homo sapiens_hsa00640	1.02912715
47	Galactose metabolism_Homo sapiens_hsa00052	1.00973071
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.96633376
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.95397943
50	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.93954230
51	DNA replication_Homo sapiens_hsa03030	0.92872642
52	Linoleic acid metabolism_Homo sapiens_hsa00591	0.91124919
53	Tyrosine metabolism_Homo sapiens_hsa00350	0.90938480
54	Cholinergic synapse_Homo sapiens_hsa04725	0.86122591
55	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.85922163
56	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.83409820
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81709151
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.81456347
59	Olfactory transduction_Homo sapiens_hsa04740	0.75977867
60	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.75216510
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.74786932
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.74295068
63	Phototransduction_Homo sapiens_hsa04744	0.72894154
64	Arginine and proline metabolism_Homo sapiens_hsa00330	0.70199249
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.67068086
66	Amphetamine addiction_Homo sapiens_hsa05031	0.64426193
67	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.60325698
68	Cocaine addiction_Homo sapiens_hsa05030	0.59106782
69	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.58909732
70	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58381353
71	RNA polymerase_Homo sapiens_hsa03020	0.58140521
72	ABC transporters_Homo sapiens_hsa02010	0.57336458
73	Complement and coagulation cascades_Homo sapiens_hsa04610	0.57001206
74	Peroxisome_Homo sapiens_hsa04146	0.55167977
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.54926032
76	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.51882838
77	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.51527889
78	Vibrio cholerae infection_Homo sapiens_hsa05110	0.50383704
79	RNA degradation_Homo sapiens_hsa03018	0.50057049
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.47201791
81	Basal transcription factors_Homo sapiens_hsa03022	0.46204792
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.44736300
83	Metabolic pathways_Homo sapiens_hsa01100	0.43863786
84	Alcoholism_Homo sapiens_hsa05034	0.43789129
85	Non-homologous end-joining_Homo sapiens_hsa03450	0.43349193
86	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.42509861
87	RNA transport_Homo sapiens_hsa03013	0.40957678
88	Spliceosome_Homo sapiens_hsa03040	0.39744619
89	Nucleotide excision repair_Homo sapiens_hsa03420	0.38954566
90	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.37681829
91	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.35056346
92	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.32228579
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.31267271
94	Oxidative phosphorylation_Homo sapiens_hsa00190	0.29353038
95	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.26744464
96	Cell cycle_Homo sapiens_hsa04110	0.25965081
97	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.25836468
98	Steroid biosynthesis_Homo sapiens_hsa00100	0.25553794
99	Salivary secretion_Homo sapiens_hsa04970	0.21587571
100	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.21438573

AHCYP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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