AHDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing two AT-hooks, which likely function in DNA binding. Mutations in this gene were found in individuals with Xia-Gibbs syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.32532412
2central nervous system myelination (GO:0022010)6.32532412
3postsynaptic membrane organization (GO:0001941)5.62594926
4presynaptic membrane assembly (GO:0097105)5.51419575
5eyelid development in camera-type eye (GO:0061029)5.40294044
6short-term memory (GO:0007614)5.19310866
7metanephric tubule development (GO:0072170)5.02718602
8metanephric nephron tubule development (GO:0072234)5.02718602
9negative regulation of execution phase of apoptosis (GO:1900118)4.98973341
10presynaptic membrane organization (GO:0097090)4.89439641
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.63359152
12negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.61611902
13metanephric nephron epithelium development (GO:0072243)4.55536457
14positive regulation of synapse maturation (GO:0090129)4.48690398
15metanephric epithelium development (GO:0072207)4.35227599
16retina layer formation (GO:0010842)4.21551629
17mesonephros development (GO:0001823)4.21293966
18DNA deamination (GO:0045006)4.20361379
19positive regulation of protein kinase C signaling (GO:0090037)3.94277523
20nephron epithelium development (GO:0072009)3.93151651
21lateral sprouting from an epithelium (GO:0060601)3.92043390
22limb bud formation (GO:0060174)3.91117726
23mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.85792322
24positive regulation of cellular amine metabolic process (GO:0033240)3.83701108
25regulation of synapse maturation (GO:0090128)3.82329956
26proline biosynthetic process (GO:0006561)3.81528733
27dendritic spine morphogenesis (GO:0060997)3.79047279
28regulation of skeletal muscle contraction (GO:0014819)3.79016148
29cellular potassium ion homeostasis (GO:0030007)3.72538283
30negative regulation of transcription by competitive promoter binding (GO:0010944)3.70630523
31enteric nervous system development (GO:0048484)3.70464395
32regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.64944346
33pattern specification involved in kidney development (GO:0061004)3.63762742
34nephron tubule formation (GO:0072079)3.59259292
35nephron tubule development (GO:0072080)3.57189950
36plasma membrane repair (GO:0001778)3.50193669
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.42997534
38face development (GO:0060324)3.38268214
39proline metabolic process (GO:0006560)3.37527347
40negative regulation of Ras GTPase activity (GO:0034261)3.36567186
41planar cell polarity pathway involved in neural tube closure (GO:0090179)3.32625123
42lymphoid progenitor cell differentiation (GO:0002320)3.32618160
43DNA ligation (GO:0006266)3.29654382
44cranial nerve morphogenesis (GO:0021602)3.23026720
45neuron cell-cell adhesion (GO:0007158)3.20325278
46collecting duct development (GO:0072044)3.19770191
47facial nerve structural organization (GO:0021612)3.16324463
48mesenchymal to epithelial transition (GO:0060231)3.15617898
49generation of neurons (GO:0048699)3.10974070
50ribosomal small subunit biogenesis (GO:0042274)3.10701610
51neuronal action potential propagation (GO:0019227)3.10396124
52regulation of pigment cell differentiation (GO:0050932)3.07934418
53muscle filament sliding (GO:0030049)3.06814922
54actin-myosin filament sliding (GO:0033275)3.06814922
55negative regulation of protein localization to cell surface (GO:2000009)3.06357885
56negative regulation of axon extension involved in axon guidance (GO:0048843)3.06247793
57oligodendrocyte differentiation (GO:0048709)3.04987187
58glial cell migration (GO:0008347)3.04773008
59renal tubule development (GO:0061326)3.03858412
60synaptic vesicle docking involved in exocytosis (GO:0016081)3.03411342
61regulation of axon extension involved in axon guidance (GO:0048841)3.02805089
62viral transcription (GO:0019083)3.01818239
63positive regulation of developmental pigmentation (GO:0048087)3.00886963
64sympathetic nervous system development (GO:0048485)3.00631855
65membrane assembly (GO:0071709)2.99771593
66vocalization behavior (GO:0071625)2.99155280
67urogenital system development (GO:0001655)2.98822891
68mitotic cell cycle arrest (GO:0071850)2.97195505
69GMP metabolic process (GO:0046037)2.96332290
70transcription from mitochondrial promoter (GO:0006390)2.96257114
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.96070177
72cranial nerve structural organization (GO:0021604)2.93558425
73GDP-mannose metabolic process (GO:0019673)2.93420831
74regulation of timing of cell differentiation (GO:0048505)2.93120977
75regulation of membrane repolarization (GO:0060306)2.91727144
76positive regulation of metanephros development (GO:0072216)2.90592227
77ensheathment of neurons (GO:0007272)2.90133812
78axon ensheathment (GO:0008366)2.90133812
79myofibril assembly (GO:0030239)2.87445264
80response to folic acid (GO:0051593)2.87320655
81regulation of respiratory system process (GO:0044065)2.87112354
82cerebellar granule cell differentiation (GO:0021707)2.86686023
83myelination (GO:0042552)2.86427213
84cardiac myofibril assembly (GO:0055003)2.85199170
85regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.84912651
86oxidative demethylation (GO:0070989)2.82874063
87positive regulation of dendritic spine development (GO:0060999)2.82493237
88negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.82297714
89spinal cord development (GO:0021510)2.80693455
90atrioventricular valve morphogenesis (GO:0003181)2.80334732
91regulation of cell proliferation involved in kidney development (GO:1901722)2.80179665
92cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.76564709
93negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.75959436
94semaphorin-plexin signaling pathway (GO:0071526)2.74905098
95cell-cell junction maintenance (GO:0045217)2.74476229
96sarcoplasmic reticulum calcium ion transport (GO:0070296)2.73837303
97camera-type eye morphogenesis (GO:0048593)2.73364277
98regulation of synapse structural plasticity (GO:0051823)2.73238636
99establishment of apical/basal cell polarity (GO:0035089)2.72698288
100cytoskeletal anchoring at plasma membrane (GO:0007016)2.72517504
101positive regulation of protein homooligomerization (GO:0032464)2.72346310
102positive regulation of dendritic spine morphogenesis (GO:0061003)2.72105790
103membrane depolarization during action potential (GO:0086010)2.71714858
104regulation of axon guidance (GO:1902667)2.71519751
105translational termination (GO:0006415)2.71191707
106cell communication by electrical coupling (GO:0010644)2.68616255
107cell proliferation in forebrain (GO:0021846)2.67838200
108genitalia morphogenesis (GO:0035112)2.67254287
109negative regulation of catenin import into nucleus (GO:0035414)2.65870082
110peripheral nervous system axon ensheathment (GO:0032292)2.65273644
111myelination in peripheral nervous system (GO:0022011)2.65273644
112response to inactivity (GO:0014854)2.62223676
113thyroid gland development (GO:0030878)2.61843174
114regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.61752172
115cellular response to ATP (GO:0071318)2.59218554
116negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.59153629
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.58674022
118negative regulation of axon guidance (GO:1902668)2.57271779
119organ growth (GO:0035265)2.57169604
120endothelium development (GO:0003158)2.55768705
121auditory receptor cell stereocilium organization (GO:0060088)2.53096633
122epithelial cell morphogenesis (GO:0003382)2.52508805
123myotube differentiation (GO:0014902)2.52316050
124regulation of respiratory gaseous exchange (GO:0043576)2.52064016
125regulation of protein kinase A signaling (GO:0010738)2.51586865
126negative regulation of myotube differentiation (GO:0010832)2.51583164
127positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.51100642
128glycogen catabolic process (GO:0005980)2.50550186
129cardiac conduction (GO:0061337)2.50509453
130negative regulation of metanephros development (GO:0072217)2.49194539
131positive regulation of fatty acid beta-oxidation (GO:0032000)2.48960643
132GPI anchor biosynthetic process (GO:0006506)2.48912099
133neuronal ion channel clustering (GO:0045161)2.48806781
134auditory behavior (GO:0031223)2.47997026
135regulation of developmental pigmentation (GO:0048070)2.47849907
136negative regulation of tumor necrosis factor production (GO:0032720)2.47617426
137endothelial cell chemotaxis (GO:0035767)2.47563758
138regulation of development, heterochronic (GO:0040034)2.47532846
139actin-mediated cell contraction (GO:0070252)2.47391781
140specification of organ identity (GO:0010092)2.47365454
141axonemal dynein complex assembly (GO:0070286)2.46744356
142regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.45888659
143head development (GO:0060322)2.45383790
144Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.45055423
145regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.44056427
146positive regulation by host of viral transcription (GO:0043923)2.44007756
147neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.43545717
148regulation of glutamate receptor signaling pathway (GO:1900449)2.41328869
149skeletal muscle fiber development (GO:0048741)2.41166757
150response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.41073522
151epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40323950
152skeletal muscle contraction (GO:0003009)2.40218649
153cell junction maintenance (GO:0034331)2.39740628
154negative regulation of potassium ion transmembrane transport (GO:1901380)2.39552447
155otic vesicle formation (GO:0030916)2.39141117
156axonal fasciculation (GO:0007413)2.38843206
157potassium ion homeostasis (GO:0055075)2.38373090
158protein heterotetramerization (GO:0051290)2.37910916
159negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.37772532
160sarcomere organization (GO:0045214)2.37724316
161transmission of nerve impulse (GO:0019226)2.37240223
162multicellular organismal signaling (GO:0035637)2.36567203
163muscle cell fate commitment (GO:0042693)2.35495209
164neuromuscular junction development (GO:0007528)2.34491851
165positive regulation of myotube differentiation (GO:0010831)2.33452109
166regulation of short-term neuronal synaptic plasticity (GO:0048172)2.33293774
167potassium ion import (GO:0010107)2.31087919
168membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.28867838
169cell migration in hindbrain (GO:0021535)2.28808538
170sodium ion export (GO:0071436)2.28569916
171regulation of heart rate by cardiac conduction (GO:0086091)2.27446135
172regulation of establishment of planar polarity (GO:0090175)2.26611965
173locomotory exploration behavior (GO:0035641)2.26150117
174regulation of p38MAPK cascade (GO:1900744)2.25823282
175positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.25700158
176cell communication involved in cardiac conduction (GO:0086065)2.23941584
177myoblast fusion (GO:0007520)2.23795213
178dopamine receptor signaling pathway (GO:0007212)2.22036350
179positive regulation of dendrite development (GO:1900006)2.20996853
180dendritic spine organization (GO:0097061)2.20802574
181ovulation cycle (GO:0042698)2.20378613
182activation of protein kinase A activity (GO:0034199)2.20287065
183positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.19716411
184glutamate secretion (GO:0014047)2.19351596
185striated muscle contraction (GO:0006941)2.18917999
186branching involved in salivary gland morphogenesis (GO:0060445)2.18419633
187regulation of neuronal synaptic plasticity (GO:0048168)2.17487995
188neuron recognition (GO:0008038)2.14940659
189non-canonical Wnt signaling pathway (GO:0035567)2.14631576
190tooth mineralization (GO:0034505)2.13929223
191actomyosin structure organization (GO:0031032)2.11688330
192cardiac muscle cell action potential involved in contraction (GO:0086002)2.11405370
193neuron projection extension involved in neuron projection guidance (GO:1902284)2.11318297
194axon extension involved in axon guidance (GO:0048846)2.11318297
195positive regulation of synapse assembly (GO:0051965)2.10784718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.73022632
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.08724608
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.08724608
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.08724608
5EZH2_27304074_Chip-Seq_ESCs_Mouse3.01390971
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85150953
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54000791
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.50173200
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42122032
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40061831
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40061831
12VDR_22108803_ChIP-Seq_LS180_Human2.36739001
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36698431
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.35544199
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33032663
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26755149
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.26359071
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25307645
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19126701
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15301835
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11415834
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.11086651
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.05185536
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04266353
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03658851
26AR_21572438_ChIP-Seq_LNCaP_Human1.94770254
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.94444971
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93967499
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.92895388
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.88305823
31RING1B_27294783_Chip-Seq_NPCs_Mouse1.87531275
32TP53_20018659_ChIP-ChIP_R1E_Mouse1.84468392
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83529552
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82861925
35* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.82093032
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81631242
37RNF2_27304074_Chip-Seq_NSC_Mouse1.77858860
38GBX2_23144817_ChIP-Seq_PC3_Human1.76851394
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74427487
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.69232826
41* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68303026
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67227541
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.65229772
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.64743072
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63634158
46IRF1_19129219_ChIP-ChIP_H3396_Human1.62416064
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57415697
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55268666
49* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52755499
50* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47408766
51* KDM2B_26808549_Chip-Seq_DND41_Human1.46237679
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.46061697
53* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.43678039
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32604136
55* CTCF_27219007_Chip-Seq_Bcells_Human1.32447043
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31155869
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.29040113
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28424732
59* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28215339
60* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28207740
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25688230
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24739792
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23778070
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22806890
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22058158
66* TP53_23651856_ChIP-Seq_MEFs_Mouse1.20780547
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.19514418
68* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18823993
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16442951
70SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14118106
71* REST_18959480_ChIP-ChIP_MESCs_Mouse1.13754200
72* KDM2B_26808549_Chip-Seq_JURKAT_Human1.12130745
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.11424603
74POU5F1_16518401_ChIP-PET_MESCs_Mouse1.10365235
75* RACK7_27058665_Chip-Seq_MCF-7_Human1.08430064
76* REST_21632747_ChIP-Seq_MESCs_Mouse1.07992817
77* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07429463
78* CREB1_26743006_Chip-Seq_LNCaP_Human1.05833627
79SMC4_20622854_ChIP-Seq_HELA_Human1.04826678
80P68_20966046_ChIP-Seq_HELA_Human1.04497393
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04256540
82* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02708469
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.01520358
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01481816
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01474202
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00621983
87* SA1_27219007_Chip-Seq_ERYTHROID_Human1.00525386
88* MYC_27129775_Chip-Seq_CORNEA_Mouse0.99520865
89* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99052170
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98979583
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98305710
92* TET1_21490601_ChIP-Seq_MESCs_Mouse0.98230326
93NFE2_27457419_Chip-Seq_LIVER_Mouse0.97230567
94* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96460379
95* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96444637
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95414388
97TP63_22573176_ChIP-Seq_HFKS_Human0.95182618
98EP300_21415370_ChIP-Seq_HL-1_Mouse0.94612376
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94357642
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94325176
101SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94201304
102OCT4_19829295_ChIP-Seq_ESCs_Human0.93209110
103STAT1_20625510_ChIP-Seq_HELA_Human0.92823527
104* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92645098
105* LXR_22292898_ChIP-Seq_THP-1_Human0.92565460
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92120779
107* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91930156
108* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90699443
109STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.90183740
110P300_18555785_Chip-Seq_ESCs_Mouse0.89879071
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89695481
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.89412352
113VDR_21846776_ChIP-Seq_THP-1_Human0.89325858
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89091331
115* AR_19668381_ChIP-Seq_PC3_Human0.88652539
116NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88610266
117DROSHA_22980978_ChIP-Seq_HELA_Human0.87717882
118ESR1_21235772_ChIP-Seq_MCF-7_Human0.87146027
119SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.85720253
120* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85707648
121* TCF7_22412390_ChIP-Seq_EML_Mouse0.85569228
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85343204
123* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84011223
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83911127
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83186396
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82095882
127* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81644359
128CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81522591
129* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.81218549
130MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.81185075
131* KDM2B_26808549_Chip-Seq_K562_Human0.80627388
132TAL1_26923725_Chip-Seq_HPCs_Mouse0.80617734
133NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79908743
134* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.79657397
135TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78588627
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77523190
137* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77128879
138KLF4_18555785_Chip-Seq_ESCs_Mouse0.76861433
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76790354
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76790354
141SMAD3_21741376_ChIP-Seq_EPCs_Human0.76237812
142* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.76034521
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.75980814
144LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75050443
145SA1_22415368_ChIP-Seq_MEFs_Mouse0.74517946
146RUNX1_27457419_Chip-Seq_LIVER_Mouse0.74376309
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74236449
148EZH2_27294783_Chip-Seq_NPCs_Mouse0.74164665
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73426638
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.73036711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color7.15694533
2MP0005409_darkened_coat_color4.87977771
3MP0004381_abnormal_hair_follicle4.46190054
4MP0001188_hyperpigmentation3.98404331
5MP0009379_abnormal_foot_pigmentation3.62310041
6MP0005171_absent_coat_pigmentation3.43815472
7MP0005174_abnormal_tail_pigmentation3.34480475
8MP0004859_abnormal_synaptic_plasticity3.19446335
9MP0003880_abnormal_central_pattern3.10510693
10MP0006292_abnormal_olfactory_placode2.72254980
11MP0002249_abnormal_larynx_morphology2.61279947
12MP0000015_abnormal_ear_pigmentation2.42309745
13MP0001348_abnormal_lacrimal_gland2.24950884
14MP0005075_abnormal_melanosome_morpholog2.14987266
15MP0003938_abnormal_ear_development2.01897764
16MP0005423_abnormal_somatic_nervous1.93890595
17MP0005503_abnormal_tendon_morphology1.88927288
18MP0000049_abnormal_middle_ear1.87874661
19MP0000579_abnormal_nail_morphology1.84942495
20MP0000749_muscle_degeneration1.83054282
21MP0005275_abnormal_skin_tensile1.82211996
22MP0004742_abnormal_vestibular_system1.77502244
23MP0003705_abnormal_hypodermis_morpholog1.73854267
24MP0008438_abnormal_cutaneous_collagen1.71424808
25MP0006072_abnormal_retinal_apoptosis1.69930280
26MP0003879_abnormal_hair_cell1.66054328
27MP0002102_abnormal_ear_morphology1.62988050
28MP0009780_abnormal_chondrocyte_physiolo1.62742688
29MP0008995_early_reproductive_senescence1.62695379
30MP0004133_heterotaxia1.61714831
31MP0003941_abnormal_skin_development1.61456597
32MP0002063_abnormal_learning/memory/cond1.59821876
33MP0002108_abnormal_muscle_morphology1.59309488
34MP0008057_abnormal_DNA_replication1.57122895
35MP0004130_abnormal_muscle_cell1.55837430
36MP0002734_abnormal_mechanical_nocicepti1.55796680
37MP0000762_abnormal_tongue_morphology1.55152513
38MP0004142_abnormal_muscle_tone1.54723853
39MP0003279_aneurysm1.54307920
40MP0005257_abnormal_intraocular_pressure1.50693724
41MP0004036_abnormal_muscle_relaxation1.49891783
42MP0000733_abnormal_muscle_development1.48587343
43MP0000467_abnormal_esophagus_morphology1.46156646
44MP0001340_abnormal_eyelid_morphology1.46135840
45MP0002177_abnormal_outer_ear1.44438931
46MP0003646_muscle_fatigue1.43405130
47MP0002282_abnormal_trachea_morphology1.43130882
48MP0000566_synostosis1.41567497
49MP0002089_abnormal_postnatal_growth/wei1.39743669
50MP0004087_abnormal_muscle_fiber1.39721761
51MP0000920_abnormal_myelination1.39622695
52MP0000759_abnormal_skeletal_muscle1.38022351
53MP0000631_abnormal_neuroendocrine_gland1.34660359
54MP0002106_abnormal_muscle_physiology1.33970067
55MP0005369_muscle_phenotype1.31216892
56MP0002272_abnormal_nervous_system1.30446270
57MP0005620_abnormal_muscle_contractility1.29111174
58MP0002751_abnormal_autonomic_nervous1.28215009
59MP0000678_abnormal_parathyroid_gland1.27986729
60MP0001440_abnormal_grooming_behavior1.26147073
61MP0003942_abnormal_urinary_system1.24769710
62MP0004134_abnormal_chest_morphology1.23493593
63MP0004084_abnormal_cardiac_muscle1.23446128
64MP0000750_abnormal_muscle_regeneration1.17763712
65MP0001958_emphysema1.17633126
66MP0000462_abnormal_digestive_system1.17467275
67MP0002837_dystrophic_cardiac_calcinosis1.17421729
68MP0000026_abnormal_inner_ear1.16778389
69MP0003878_abnormal_ear_physiology1.15163463
70MP0005377_hearing/vestibular/ear_phenot1.15163463
71MP0002733_abnormal_thermal_nociception1.14280325
72MP0001486_abnormal_startle_reflex1.13925766
73MP0010030_abnormal_orbit_morphology1.13854949
74MP0002938_white_spotting1.13463201
75MP0000778_abnormal_nervous_system1.13374098
76MP0002095_abnormal_skin_pigmentation1.12630770
77MP0002009_preneoplasia1.09645914
78MP0002796_impaired_skin_barrier1.07392961
79MP0005508_abnormal_skeleton_morphology1.06961125
80MP0004858_abnormal_nervous_system1.06835177
81MP0000751_myopathy1.06419503
82MP0002932_abnormal_joint_morphology1.05455669
83MP0000534_abnormal_ureter_morphology1.05402318
84MP0002822_catalepsy1.05097815
85MP0002735_abnormal_chemical_nociception1.04000927
86MP0000613_abnormal_salivary_gland1.03429683
87MP0000747_muscle_weakness1.03093370
88MP0000013_abnormal_adipose_tissue1.01786286
89MP0009053_abnormal_anal_canal1.01357234
90MP0005645_abnormal_hypothalamus_physiol1.00764017
91MP0000767_abnormal_smooth_muscle1.00584080
92MP0002653_abnormal_ependyma_morphology1.00439656
93MP0003724_increased_susceptibility_to1.00025135
94MP0009384_cardiac_valve_regurgitation0.99428345
95MP0001299_abnormal_eye_distance/0.99056257
96MP0005595_abnormal_vascular_smooth0.99010825
97MP0002752_abnormal_somatic_nervous0.98617012
98MP0001853_heart_inflammation0.98230070
99MP0001502_abnormal_circadian_rhythm0.95236771
100MP0000470_abnormal_stomach_morphology0.93806832
101MP0004885_abnormal_endolymph0.93708153
102MP0005670_abnormal_white_adipose0.93576596
103MP0003385_abnormal_body_wall0.93071305
104MP0009250_abnormal_appendicular_skeleto0.91944746
105MP0009278_abnormal_bone_marrow0.91886434
106MP0009046_muscle_twitch0.91717491
107MP0001970_abnormal_pain_threshold0.90719473
108MP0008569_lethality_at_weaning0.88105264
109MP0000383_abnormal_hair_follicle0.87807486
110MP0010368_abnormal_lymphatic_system0.87711043
111MP0000428_abnormal_craniofacial_morphol0.87208806
112MP0000681_abnormal_thyroid_gland0.86420761
113MP0001485_abnormal_pinna_reflex0.86409877
114MP0004272_abnormal_basement_membrane0.86154944
115MP0001968_abnormal_touch/_nociception0.85500603
116MP0005165_increased_susceptibility_to0.84163686
117MP0002557_abnormal_social/conspecific_i0.83644989
118MP0001849_ear_inflammation0.83227633
119MP0002067_abnormal_sensory_capabilities0.82851402
120MP0003755_abnormal_palate_morphology0.82727823
121MP0001963_abnormal_hearing_physiology0.81638381
122MP0010630_abnormal_cardiac_muscle0.80679718
123MP0003453_abnormal_keratinocyte_physiol0.79433265
124MP0000003_abnormal_adipose_tissue0.79249128
125MP0005410_abnormal_fertilization0.78849153
126MP0003828_pulmonary_edema0.77670077
127MP0002116_abnormal_craniofacial_bone0.77174471
128MP0000163_abnormal_cartilage_morphology0.76936362
129MP0005551_abnormal_eye_electrophysiolog0.76882919
130MP0002184_abnormal_innervation0.76716997
131MP0000955_abnormal_spinal_cord0.76534760
132MP0009745_abnormal_behavioral_response0.76278405
133MP0002882_abnormal_neuron_morphology0.75184867
134MP0003635_abnormal_synaptic_transmissio0.74840062
135MP0002064_seizures0.73833294
136MP0005391_vision/eye_phenotype0.72236941
137MP0003137_abnormal_impulse_conducting0.71686159
138MP0003937_abnormal_limbs/digits/tail_de0.71622737
139MP0004145_abnormal_muscle_electrophysio0.71122582
140MP0000432_abnormal_head_morphology0.70262328
141MP0005253_abnormal_eye_physiology0.70068252
142MP0003959_abnormal_lean_body0.69272253
143MP0001346_abnormal_lacrimal_gland0.69113443
144MP0003935_abnormal_craniofacial_develop0.69079139
145MP0003045_fibrosis0.68870819
146MP0002572_abnormal_emotion/affect_behav0.67900005
147MP0003283_abnormal_digestive_organ0.67007643
148MP0005195_abnormal_posterior_eye0.65340703
149MP0002111_abnormal_tail_morphology0.63872532
150MP0002114_abnormal_axial_skeleton0.63782164
151MP0003634_abnormal_glial_cell0.61639168
152MP0002075_abnormal_coat/hair_pigmentati0.61524681
153MP0002098_abnormal_vibrissa_morphology0.61365349
154MP0001293_anophthalmia0.60989589
155MP0004270_analgesia0.60684681
156MP0001286_abnormal_eye_development0.57720834

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of secondary sexual hair (HP:0009888)6.84063285
2Abnormality of the axillary hair (HP:0100134)6.84063285
3Sex reversal (HP:0012245)6.62355313
4Abnormal sex determination (HP:0012244)6.62355313
5Alacrima (HP:0000522)5.02966228
6Concave nail (HP:0001598)4.48075266
7Type 1 muscle fiber predominance (HP:0003803)4.29648683
8Decreased lacrimation (HP:0000633)4.09561430
9Round ear (HP:0100830)3.99316565
10Thyroid-stimulating hormone excess (HP:0002925)3.80660362
11* Obstructive sleep apnea (HP:0002870)3.56301362
12Split foot (HP:0001839)3.48844118
13Septo-optic dysplasia (HP:0100842)3.48644201
14Optic nerve hypoplasia (HP:0000609)3.25493084
15Annular pancreas (HP:0001734)3.22468928
16Muscle fiber inclusion bodies (HP:0100299)3.20622739
17Distal arthrogryposis (HP:0005684)3.18534200
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.17400487
19Attenuation of retinal blood vessels (HP:0007843)3.16046140
20Peripheral hypomyelination (HP:0007182)3.13965882
21Nemaline bodies (HP:0003798)3.11276335
22Ulnar deviation of the wrist (HP:0003049)3.09966590
23Shallow orbits (HP:0000586)3.09214689
24Absent septum pellucidum (HP:0001331)3.06734412
25Gonadal dysgenesis (HP:0000133)3.06367358
26Exercise-induced myalgia (HP:0003738)3.00193086
27Abnormal respiratory epithelium morphology (HP:0012253)2.96007281
28Abnormal respiratory motile cilium morphology (HP:0005938)2.96007281
29Muscle fiber splitting (HP:0003555)2.95065882
30Rib fusion (HP:0000902)2.90001797
31Type I transferrin isoform profile (HP:0003642)2.89372778
32Hip contracture (HP:0003273)2.83114301
33Hypoplasia of the ulna (HP:0003022)2.79929641
34Parakeratosis (HP:0001036)2.78492452
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.74772174
36Intestinal atresia (HP:0011100)2.69733705
37Genetic anticipation (HP:0003743)2.69581395
38Aplasia involving bones of the extremities (HP:0009825)2.69156958
39Aplasia involving bones of the upper limbs (HP:0009823)2.69156958
40Aplasia of the phalanges of the hand (HP:0009802)2.69156958
41Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.68320481
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.66619598
43Absent/shortened dynein arms (HP:0200106)2.66619598
44Hypotrichosis (HP:0001006)2.65256621
45Reduced antithrombin III activity (HP:0001976)2.65185071
46Myotonia (HP:0002486)2.61556891
47Abnormality of the septum pellucidum (HP:0007375)2.61369456
48Calf muscle hypertrophy (HP:0008981)2.59233188
49Increased connective tissue (HP:0009025)2.58805483
50Hyporeflexia of lower limbs (HP:0002600)2.58036185
51Muscle hypertrophy of the lower extremities (HP:0008968)2.57284476
52White forelock (HP:0002211)2.55750953
53Increased variability in muscle fiber diameter (HP:0003557)2.54546192
54Premature skin wrinkling (HP:0100678)2.53531455
55Hypoplasia of the radius (HP:0002984)2.50072130
56Turricephaly (HP:0000262)2.44217003
57Coronal craniosynostosis (HP:0004440)2.43766804
58Sudden death (HP:0001699)2.43735297
59Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.41274146
60Short 4th metacarpal (HP:0010044)2.41274146
61Aplasia/Hypoplasia of the ulna (HP:0006495)2.39553841
62Aplasia involving forearm bones (HP:0009822)2.36358778
63Absent forearm bone (HP:0003953)2.36358778
64Protrusio acetabuli (HP:0003179)2.36187925
65Limited hip movement (HP:0008800)2.33379100
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32872891
67Abnormality of skeletal muscle fiber size (HP:0012084)2.31428355
68Abnormality of cells of the erythroid lineage (HP:0012130)2.29306841
69Patchy hypopigmentation of hair (HP:0011365)2.28995494
70Abnormal number of erythroid precursors (HP:0012131)2.28564898
71Supernumerary spleens (HP:0009799)2.28431349
72Abnormal ciliary motility (HP:0012262)2.27175191
73Amelogenesis imperfecta (HP:0000705)2.26937005
74Male pseudohermaphroditism (HP:0000037)2.26674093
75Absent radius (HP:0003974)2.26590858
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26029147
77Mildly elevated creatine phosphokinase (HP:0008180)2.25770669
78Chin dimple (HP:0010751)2.25268771
79Ocular albinism (HP:0001107)2.25227334
80Diplopia (HP:0000651)2.25116844
81Abnormality of binocular vision (HP:0011514)2.25116844
82Absent phalangeal crease (HP:0006109)2.24987561
83Broad metatarsal (HP:0001783)2.24225011
84Calcaneovalgus deformity (HP:0001848)2.22153318
85Fetal akinesia sequence (HP:0001989)2.21469096
86Cerebral aneurysm (HP:0004944)2.19930381
87Myopathic facies (HP:0002058)2.19797068
88Renal agenesis (HP:0000104)2.19281891
89Hypoplastic ischia (HP:0003175)2.18512838
90Fragile skin (HP:0001030)2.18273955
91Germ cell neoplasia (HP:0100728)2.17963895
92Nonprogressive disorder (HP:0003680)2.16459325
93Flat occiput (HP:0005469)2.16388436
94Abnormality of the calf musculature (HP:0001430)2.15096115
95Asplenia (HP:0001746)2.14357010
96Spinal rigidity (HP:0003306)2.10489701
97Scapular winging (HP:0003691)2.10316415
98Distal lower limb muscle weakness (HP:0009053)2.09957813
99Abnormal respiratory motile cilium physiology (HP:0012261)2.09936591
100Prolonged partial thromboplastin time (HP:0003645)2.08148163
101Esophageal atresia (HP:0002032)2.07335516
102Partial duplication of thumb phalanx (HP:0009944)2.07314458
103Anophthalmia (HP:0000528)2.04549815
104Myokymia (HP:0002411)2.04157159
105Lower limb amyotrophy (HP:0007210)2.03699090
106Popliteal pterygium (HP:0009756)2.02462687
107Abnormality of the aortic arch (HP:0012303)2.02285700
108Prolonged QT interval (HP:0001657)2.00786211
109Difficulty running (HP:0009046)1.99741246
110Gastrointestinal atresia (HP:0002589)1.96781026
111Thin ribs (HP:0000883)1.95972855
112Broad face (HP:0000283)1.95686778
113Neoplasm of the heart (HP:0100544)1.95572538
114Distal lower limb amyotrophy (HP:0008944)1.95535297
115Deformed tarsal bones (HP:0008119)1.95499677
116Abnormality of magnesium homeostasis (HP:0004921)1.94724672
117Morphological abnormality of the inner ear (HP:0011390)1.93636793
118Bladder diverticulum (HP:0000015)1.92895786
119Facial hemangioma (HP:0000329)1.90663873
120Synostosis of carpal bones (HP:0005048)1.90382863
121Short tibia (HP:0005736)1.90218556
122Aplasia/Hypoplasia of the spleen (HP:0010451)1.89642102
123Stridor (HP:0010307)1.88805135
124Forearm undergrowth (HP:0009821)1.88520538
125Anteriorly placed anus (HP:0001545)1.87963786
126Atrophic scars (HP:0001075)1.87564025
127Iris hypopigmentation (HP:0007730)1.87454558
128Lower limb hyperreflexia (HP:0002395)1.87296936
129Neonatal short-limb short stature (HP:0008921)1.87286263
130Lymphangioma (HP:0100764)1.86536364
131Hyperacusis (HP:0010780)1.85856014
132Abnormality of the ischium (HP:0003174)1.85824542
133Split hand (HP:0001171)1.85721563
134Premature rupture of membranes (HP:0001788)1.85651563
135Aplasia of the musculature (HP:0100854)1.85072458
136Progressive cerebellar ataxia (HP:0002073)1.84734223
137Oligodontia (HP:0000677)1.84378287
138Subaortic stenosis (HP:0001682)1.83137145
139Abnormality of the left ventricular outflow tract (HP:0011103)1.83137145
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82770986
141Broad hallux (HP:0010055)1.82673526
142Abnormality of the 4th metacarpal (HP:0010012)1.82537719
143Hypothermia (HP:0002045)1.81642986
144Partial duplication of the phalanx of hand (HP:0009999)1.81396570
145Bronchomalacia (HP:0002780)1.81145604
146Abnormal hemoglobin (HP:0011902)1.79636640
147Short chin (HP:0000331)1.77932055
148Akinesia (HP:0002304)1.77309298
149Hypochromic microcytic anemia (HP:0004840)1.77165715
150Clumsiness (HP:0002312)1.76889703
151Difficulty climbing stairs (HP:0003551)1.75090770
152Hypomagnesemia (HP:0002917)1.74952500
153Abnormality of the radial head (HP:0003995)1.74749119
154Small hand (HP:0200055)1.74728531
155Bile duct proliferation (HP:0001408)1.74590767
156Abnormal biliary tract physiology (HP:0012439)1.74590767
157Spinal canal stenosis (HP:0003416)1.73899727
158Persistence of primary teeth (HP:0006335)1.73381492
159Radial bowing (HP:0002986)1.73050326
160Fatigable weakness (HP:0003473)1.72937284
161Abnormality of the neuromuscular junction (HP:0003398)1.72937284
162Aortic regurgitation (HP:0001659)1.70784213
163Aplasia/Hypoplasia of the tibia (HP:0005772)1.70492473
164Partial agenesis of the corpus callosum (HP:0001338)1.70372332
165Rectal fistula (HP:0100590)1.70336711
166Rectovaginal fistula (HP:0000143)1.70336711
167Cutaneous finger syndactyly (HP:0010554)1.70278231
168Hypoplasia of the iris (HP:0007676)1.69958365
169Bowing of the arm (HP:0006488)1.69727177
170Bowed forearm bones (HP:0003956)1.69727177
171Dislocated radial head (HP:0003083)1.69257670
172Asymmetric septal hypertrophy (HP:0001670)1.68633788
173Anomalous pulmonary venous return (HP:0010772)1.68597685
174Abnormality of male internal genitalia (HP:0000022)1.68521364
175Abnormal finger flexion creases (HP:0006143)1.68428765
176Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.67978262
177Hypoplastic pelvis (HP:0008839)1.67918030
178Mitral regurgitation (HP:0001653)1.66902193
179Hypoventilation (HP:0002791)1.66804647
180Tarsal synostosis (HP:0008368)1.66642778
181Aortic aneurysm (HP:0004942)1.66507382
182EMG: neuropathic changes (HP:0003445)1.66334341
183Overfolded helix (HP:0000396)1.66150003
184Absent speech (HP:0001344)1.65753153
185Pointed chin (HP:0000307)1.65357342
186Action tremor (HP:0002345)1.64749573
187Hemiplegia (HP:0002301)1.64585319
188Median cleft lip (HP:0000161)1.64487552
189EMG: myopathic abnormalities (HP:0003458)1.63635859
190Decreased central vision (HP:0007663)1.62781811
191Duplication of thumb phalanx (HP:0009942)1.60926622
192Morphological abnormality of the middle ear (HP:0008609)1.60666915
193Bradycardia (HP:0001662)1.59432509
194Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.58957123
195Macrocytic anemia (HP:0001972)1.56819152
196Cutaneous syndactyly (HP:0012725)1.55669662
197Cupped ear (HP:0000378)1.54064696

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.09423828
2TNIK6.03268605
3MAPK154.13749110
4SIK13.24321866
5PHKG12.99187120
6PHKG22.99187120
7TRIB32.93144469
8ICK2.76719105
9MARK12.75706833
10MKNK22.63831054
11TTN2.58859194
12DDR22.34930022
13RIPK12.24578783
14FGR2.15233570
15OBSCN1.96635762
16UHMK11.93609061
17PRKD21.91847230
18NLK1.90430871
19MUSK1.86077925
20MAP3K71.83012250
21EIF2AK31.77418540
22YES11.76641916
23LATS21.76069762
24MATK1.74816763
25NTRK11.62636533
26BLK1.62060895
27CDK121.56932768
28FES1.55196699
29EEF2K1.54887364
30FGFR21.54849443
31EPHB21.54557173
32MAP3K61.50364611
33STK161.47837654
34MAP3K91.39556700
35STK391.37105104
36CLK11.36529891
37PRKD31.36280634
38SIK21.33196548
39MKNK11.31499425
40RPS6KA21.29408262
41MAP3K11.28423742
42MAPK121.26817595
43PKN11.24563622
44EPHA21.17544216
45SGK2231.16704434
46SGK4941.16704434
47PAK21.16451348
48TYRO31.14829395
49CSK1.13881373
50PINK11.12963901
51PRKCH1.11101986
52GRK11.10849946
53TLK11.10644273
54MAPK71.08873041
55MTOR1.05888045
56MAP3K101.02568325
57PTK21.01409614
58NTRK30.98773684
59DAPK20.98443923
60PAK60.96359332
61DYRK20.94528351
62MYLK0.94525494
63EIF2AK20.93373424
64TNK20.93115362
65CAMK2B0.92980829
66CDK70.91232199
67PIM20.90529857
68SGK20.88546124
69MAPKAPK30.86417423
70SMG10.85984384
71ROCK10.84597138
72DYRK1B0.82214357
73PRPF4B0.82103083
74PRKAA20.82099597
75OXSR10.81892157
76SGK30.81228609
77HIPK20.78487547
78MARK20.77434424
79PTK2B0.76937706
80CAMKK10.76800018
81GSK3A0.73856267
82STK380.72918414
83ERBB20.72780315
84IRAK20.70549593
85NME10.69338488
86CAMK10.68405820
87CDK190.68022200
88PDGFRB0.68004325
89NTRK20.67046854
90EPHA40.66891069
91TRPM70.65269624
92MAPKAPK50.64426020
93CDK30.64075821
94PKN20.63542621
95CAMK2A0.63185034
96GRK70.63165273
97PRKAA10.63034230
98SGK10.62608992
99MAPK130.61511272
100CSNK1G10.60595654
101VRK10.59880895
102INSRR0.58351737
103DYRK30.58050556
104MAP3K110.57595839
105CDC42BPA0.56923613
106PAK10.55005273
107ADRBK20.54655987
108EPHB10.54564085
109WNK10.54166918
110TAOK10.53660721
111BMX0.53355168
112PDGFRA0.51601406
113FGFR40.51519507
114PRKCG0.51465020
115PRKD10.51419848
116CAMK2D0.50718321
117MAPK80.50418127
118RPS6KA30.48988469
119CAMK1D0.48707891
120MAP2K20.46952144
121IRAK10.46842805
122MAPK40.46611430
123CAMK40.45535121
124PTK60.45372229
125TIE10.45070392
126CAMK1G0.44860341
127PRKG10.44766791
128BMPR1B0.43357961
129CAMK2G0.41964411
130DMPK0.41231107
131RPS6KC10.38885670
132RPS6KL10.38885670
133IRAK40.38224222
134ROCK20.37335437
135STK110.36751868
136KIT0.36699071
137LYN0.35928596
138RPS6KA60.34054793
139FER0.33287184
140DAPK10.31351460
141LCK0.30948109
142MAPK110.30635036
143NEK60.28133969
144MAPK100.24076174
145MST40.23125791
146DAPK30.23011415
147CSNK1G30.22945416
148CDK50.22239263
149PRKACA0.21734001
150CSNK1D0.21616858
151PIM10.19551997
152TEC0.19535769
153CSNK1A1L0.18715726
154DYRK1A0.18054008
155PIK3CG0.17776056
156CSNK2A20.16614818

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.19586849
2Ribosome_Homo sapiens_hsa030103.09715757
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.68978979
4Fatty acid biosynthesis_Homo sapiens_hsa000612.64319943
5Phototransduction_Homo sapiens_hsa047442.43837473
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16953194
7Hedgehog signaling pathway_Homo sapiens_hsa043402.13178706
8Fanconi anemia pathway_Homo sapiens_hsa034602.12238594
9Insulin secretion_Homo sapiens_hsa049112.06568390
10Basal cell carcinoma_Homo sapiens_hsa052172.06509161
11Fatty acid elongation_Homo sapiens_hsa000622.06175867
12Mismatch repair_Homo sapiens_hsa034301.99268835
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.89207438
14Nicotine addiction_Homo sapiens_hsa050331.87874754
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.87796056
16Axon guidance_Homo sapiens_hsa043601.85614273
17DNA replication_Homo sapiens_hsa030301.82026876
18Wnt signaling pathway_Homo sapiens_hsa043101.76441024
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71699302
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70408463
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.67190635
22Long-term potentiation_Homo sapiens_hsa047201.65021261
23Cholinergic synapse_Homo sapiens_hsa047251.64954669
24Base excision repair_Homo sapiens_hsa034101.64083785
25Ether lipid metabolism_Homo sapiens_hsa005651.63581721
26Protein export_Homo sapiens_hsa030601.63365723
27Notch signaling pathway_Homo sapiens_hsa043301.61483734
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56583962
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.56121686
30Circadian rhythm_Homo sapiens_hsa047101.51504468
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45134872
32Long-term depression_Homo sapiens_hsa047301.43012342
33Focal adhesion_Homo sapiens_hsa045101.38317614
34Synaptic vesicle cycle_Homo sapiens_hsa047211.37589289
35Glutamatergic synapse_Homo sapiens_hsa047241.37488845
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37481483
37Dopaminergic synapse_Homo sapiens_hsa047281.35534708
38Sphingolipid metabolism_Homo sapiens_hsa006001.35104208
39Linoleic acid metabolism_Homo sapiens_hsa005911.33376804
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28753743
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26049436
42Melanogenesis_Homo sapiens_hsa049161.24469242
43Arachidonic acid metabolism_Homo sapiens_hsa005901.21089108
44Other glycan degradation_Homo sapiens_hsa005111.17249950
45Calcium signaling pathway_Homo sapiens_hsa040201.16246174
46Glioma_Homo sapiens_hsa052141.15704268
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12991092
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10801041
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09591418
50Homologous recombination_Homo sapiens_hsa034401.09097459
51Spliceosome_Homo sapiens_hsa030401.08732841
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05463416
53Estrogen signaling pathway_Homo sapiens_hsa049151.05365063
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05046529
55Taste transduction_Homo sapiens_hsa047421.04575995
56Arginine and proline metabolism_Homo sapiens_hsa003301.03934707
57Cardiac muscle contraction_Homo sapiens_hsa042601.02455661
58Serotonergic synapse_Homo sapiens_hsa047261.02122521
59Thyroid cancer_Homo sapiens_hsa052161.01702109
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99483972
61VEGF signaling pathway_Homo sapiens_hsa043700.98426705
62Type II diabetes mellitus_Homo sapiens_hsa049300.96399698
63GnRH signaling pathway_Homo sapiens_hsa049120.96163923
64Melanoma_Homo sapiens_hsa052180.95479577
65Protein digestion and absorption_Homo sapiens_hsa049740.93908767
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93635193
67Nucleotide excision repair_Homo sapiens_hsa034200.92683822
68Primary immunodeficiency_Homo sapiens_hsa053400.91839784
69Gap junction_Homo sapiens_hsa045400.91129184
70Morphine addiction_Homo sapiens_hsa050320.89200077
71ErbB signaling pathway_Homo sapiens_hsa040120.88997120
72GABAergic synapse_Homo sapiens_hsa047270.87008392
73Glucagon signaling pathway_Homo sapiens_hsa049220.85948714
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.85410648
75ABC transporters_Homo sapiens_hsa020100.85014761
76Bile secretion_Homo sapiens_hsa049760.84711666
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.83550277
78Insulin signaling pathway_Homo sapiens_hsa049100.81791231
79Salivary secretion_Homo sapiens_hsa049700.80768629
80Hippo signaling pathway_Homo sapiens_hsa043900.79932378
81Sulfur relay system_Homo sapiens_hsa041220.79713906
82Dorso-ventral axis formation_Homo sapiens_hsa043200.79157322
83MAPK signaling pathway_Homo sapiens_hsa040100.78289652
84Ras signaling pathway_Homo sapiens_hsa040140.77543809
85Renal cell carcinoma_Homo sapiens_hsa052110.77452752
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75940500
87Lysine degradation_Homo sapiens_hsa003100.75796049
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75306520
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75138681
90Olfactory transduction_Homo sapiens_hsa047400.75126520
91Choline metabolism in cancer_Homo sapiens_hsa052310.74206421
92Prion diseases_Homo sapiens_hsa050200.73454501
93Amphetamine addiction_Homo sapiens_hsa050310.71436312
94Cocaine addiction_Homo sapiens_hsa050300.70136090
95cAMP signaling pathway_Homo sapiens_hsa040240.69574968
96AMPK signaling pathway_Homo sapiens_hsa041520.67981151
97Insulin resistance_Homo sapiens_hsa049310.67796411
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67529072
99Tight junction_Homo sapiens_hsa045300.66958252
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65689445
101Proteoglycans in cancer_Homo sapiens_hsa052050.64488945
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64100802
103mTOR signaling pathway_Homo sapiens_hsa041500.63883071
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63566818
105Thyroid hormone synthesis_Homo sapiens_hsa049180.62361515
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61823106
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61114367
108Amoebiasis_Homo sapiens_hsa051460.60382693
109Autoimmune thyroid disease_Homo sapiens_hsa053200.59573459
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57780270
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56808855
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56609020
113Oxidative phosphorylation_Homo sapiens_hsa001900.56361302
114Endometrial cancer_Homo sapiens_hsa052130.55218013
115Circadian entrainment_Homo sapiens_hsa047130.54631654
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.54163423
117Pathways in cancer_Homo sapiens_hsa052000.51501941
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51373232
119MicroRNAs in cancer_Homo sapiens_hsa052060.50292070
120Alzheimers disease_Homo sapiens_hsa050100.48806047
121Renin secretion_Homo sapiens_hsa049240.47750943
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46713401
123Gastric acid secretion_Homo sapiens_hsa049710.46070221
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.45470320
125ECM-receptor interaction_Homo sapiens_hsa045120.45424030
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43842376
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.43733537
128Pancreatic secretion_Homo sapiens_hsa049720.42478469
129TGF-beta signaling pathway_Homo sapiens_hsa043500.41610004
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39122903
131Ovarian steroidogenesis_Homo sapiens_hsa049130.38365372
132Adherens junction_Homo sapiens_hsa045200.38354452
133Acute myeloid leukemia_Homo sapiens_hsa052210.34562574
134Bladder cancer_Homo sapiens_hsa052190.34261883
135p53 signaling pathway_Homo sapiens_hsa041150.33395711
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.31520745
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31312971
138Histidine metabolism_Homo sapiens_hsa003400.30475527
139Dilated cardiomyopathy_Homo sapiens_hsa054140.30187152
140Rap1 signaling pathway_Homo sapiens_hsa040150.29603818
141Oxytocin signaling pathway_Homo sapiens_hsa049210.29373061
142Vitamin digestion and absorption_Homo sapiens_hsa049770.29159728
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.28875819
144Asthma_Homo sapiens_hsa053100.28823009

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