AHNAK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.36357257
2neurofilament cytoskeleton organization (GO:0060052)6.03311790
3hemidesmosome assembly (GO:0031581)6.01992688
4neuron projection extension involved in neuron projection guidance (GO:1902284)4.83965075
5axon extension involved in axon guidance (GO:0048846)4.83965075
6intermediate filament organization (GO:0045109)4.75214025
7collagen fibril organization (GO:0030199)4.38568121
8establishment of skin barrier (GO:0061436)4.13608741
9skin morphogenesis (GO:0043589)4.09390756
10cell adhesion mediated by integrin (GO:0033627)4.03873241
11endodermal cell differentiation (GO:0035987)4.01380471
12hair cycle (GO:0042633)3.94837875
13molting cycle (GO:0042303)3.94837875
14regulation of water loss via skin (GO:0033561)3.94752879
15epidermal cell differentiation (GO:0009913)3.88517978
16epidermis development (GO:0008544)3.83391401
17wound healing, spreading of epidermal cells (GO:0035313)3.75639041
18protein heterotrimerization (GO:0070208)3.69804441
19hypotonic response (GO:0006971)3.61247102
20positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.55799440
21chondrocyte proliferation (GO:0035988)3.54664600
22mesodermal cell differentiation (GO:0048333)3.54653862
23peptide cross-linking (GO:0018149)3.53642592
24negative regulation of keratinocyte proliferation (GO:0010839)3.52635192
25water homeostasis (GO:0030104)3.51084490
26negative regulation of chondrocyte differentiation (GO:0032331)3.48730909
27intermediate filament cytoskeleton organization (GO:0045104)3.45226108
28surfactant homeostasis (GO:0043129)3.41587725
29intermediate filament-based process (GO:0045103)3.41496832
30establishment of planar polarity (GO:0001736)3.38417646
31establishment of tissue polarity (GO:0007164)3.38417646
32collagen catabolic process (GO:0030574)3.38267764
33regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.36589575
34regulation of transforming growth factor beta2 production (GO:0032909)3.36015783
35collagen metabolic process (GO:0032963)3.34842508
36sequestering of extracellular ligand from receptor (GO:0035581)3.30796643
37mesenchymal-epithelial cell signaling (GO:0060638)3.27938348
38cellular response to vitamin D (GO:0071305)3.24061373
39keratinization (GO:0031424)3.23747994
40cell-substrate junction assembly (GO:0007044)3.22776131
41cellular response to interferon-alpha (GO:0035457)3.22476273
42substrate-dependent cell migration (GO:0006929)3.21514201
43membrane budding (GO:0006900)3.20386855
44cytoskeletal anchoring at plasma membrane (GO:0007016)3.14669252
45gap junction assembly (GO:0016264)3.13069058
46keratinocyte proliferation (GO:0043616)3.12866852
47basement membrane organization (GO:0071711)3.10578657
48vascular endothelial growth factor signaling pathway (GO:0038084)3.10461016
49multicellular organismal macromolecule metabolic process (GO:0044259)3.09793776
50cell-substrate adherens junction assembly (GO:0007045)3.06700665
51focal adhesion assembly (GO:0048041)3.06700665
52peptidyl-proline hydroxylation (GO:0019511)3.06643984
53multicellular organismal catabolic process (GO:0044243)3.05938739
54* plasma membrane repair (GO:0001778)3.05554858
55polarized epithelial cell differentiation (GO:0030859)3.03722885
56cell junction assembly (GO:0034329)3.02921936
57positive regulation of endothelial cell apoptotic process (GO:2000353)3.01177867
58extracellular matrix disassembly (GO:0022617)3.00330907
59Golgi transport vesicle coating (GO:0048200)3.00186586
60COPI coating of Golgi vesicle (GO:0048205)3.00186586
61fibroblast migration (GO:0010761)2.99207893
62adherens junction assembly (GO:0034333)2.98878337
63protein hydroxylation (GO:0018126)2.98342969
64regulation of phospholipase A2 activity (GO:0032429)2.96031617
65cellular response to vitamin (GO:0071295)2.95780010
66wound healing, spreading of cells (GO:0044319)2.94275012
67positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.92543188
68keratinocyte differentiation (GO:0030216)2.91453867
69cell junction organization (GO:0034330)2.91188151
70extracellular matrix assembly (GO:0085029)2.90666817
71bundle of His cell to Purkinje myocyte communication (GO:0086069)2.90185018
72regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.90160739
73multicellular organismal metabolic process (GO:0044236)2.89670571
74apoptotic cell clearance (GO:0043277)2.88786642
75negative regulation of stem cell proliferation (GO:2000647)2.86452048
76bone trabecula formation (GO:0060346)2.86135314
77negative regulation of anoikis (GO:2000811)2.84642917
78protein targeting to plasma membrane (GO:0072661)2.79880925
79endothelial cell chemotaxis (GO:0035767)2.77512664
80glomerular visceral epithelial cell development (GO:0072015)2.76664514
81positive regulation of axon extension (GO:0045773)2.76261597
82extracellular fibril organization (GO:0043206)2.75973899
83regulation of hair follicle development (GO:0051797)2.74908377
84barbed-end actin filament capping (GO:0051016)2.72168977
85regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70791215
86endothelial cell morphogenesis (GO:0001886)2.68828206
87regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.68640676
88regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.67665502
89chemical homeostasis within a tissue (GO:0048875)2.65648524
90regulation of anoikis (GO:2000209)2.65410977
91lateral sprouting from an epithelium (GO:0060601)2.64902456
92protein localization to endosome (GO:0036010)2.64739377
93detection of temperature stimulus (GO:0016048)2.64733140
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63240932
95negative regulation of dendrite morphogenesis (GO:0050774)2.60598304
96regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59910804
97wound healing (GO:0042060)2.59501884
98positive regulation of fibroblast migration (GO:0010763)2.59464245
99regulation of keratinocyte proliferation (GO:0010837)2.57810506
100dermatan sulfate biosynthetic process (GO:0030208)2.56194008
101regulation of endothelial cell chemotaxis (GO:2001026)2.55865874
102planar cell polarity pathway involved in neural tube closure (GO:0090179)2.55854721
103syncytium formation by plasma membrane fusion (GO:0000768)2.55450603
104syncytium formation (GO:0006949)2.55342997
105positive regulation of blood vessel endothelial cell migration (GO:0043536)2.54598835
106cell-cell junction assembly (GO:0007043)2.54306080
107negative regulation of leukocyte chemotaxis (GO:0002689)2.54085321
108positive regulation of odontogenesis (GO:0042482)2.53843246
109negative regulation of cartilage development (GO:0061037)2.52503523
110Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.51900647
111epithelial cell-cell adhesion (GO:0090136)2.51469870
112multicellular organismal water homeostasis (GO:0050891)2.51331032
113sphingosine metabolic process (GO:0006670)2.49452752
114retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49254256
115mammary gland epithelial cell proliferation (GO:0033598)2.48819030
116activation of Rac GTPase activity (GO:0032863)2.48306744
117membrane raft organization (GO:0031579)2.48212094
118dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.47905749
119myoblast fusion (GO:0007520)2.47881884
120negative regulation of fatty acid transport (GO:2000192)2.47789528
121positive regulation of epidermal cell differentiation (GO:0045606)2.47266893
122detection of temperature stimulus involved in sensory perception (GO:0050961)2.46247154
123detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.46247154
124smooth muscle tissue development (GO:0048745)2.45654544
125muscle cell migration (GO:0014812)2.45492677
126regulation of establishment of planar polarity (GO:0090175)2.45338551
127fibril organization (GO:0097435)2.45194967
128negative chemotaxis (GO:0050919)2.42441460
129phospholipid scrambling (GO:0017121)2.42071703
130axon extension (GO:0048675)2.41541737
131atrioventricular valve morphogenesis (GO:0003181)2.41139584
132cellular response to amino acid stimulus (GO:0071230)2.39973731
133skin development (GO:0043588)2.39666417
134regulation of monocyte chemotaxis (GO:0090025)2.39052620
135semaphorin-plexin signaling pathway (GO:0071526)2.37191749
136regulation of membrane protein ectodomain proteolysis (GO:0051043)2.36901287
137positive regulation of p38MAPK cascade (GO:1900745)2.35498206
138negative regulation of cell-substrate adhesion (GO:0010812)2.35473622
139metanephric mesenchyme development (GO:0072075)2.35420458
140sphingoid metabolic process (GO:0046519)2.35174364
141glomerular epithelial cell development (GO:0072310)2.33749784
142positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.33115409
143glomerular basement membrane development (GO:0032836)2.32762248
144negative regulation of interleukin-8 production (GO:0032717)2.32102929
145neuron projection extension (GO:1990138)2.31359966
146renal filtration (GO:0097205)2.31023178
147regulation of early endosome to late endosome transport (GO:2000641)2.29968685
148dermatan sulfate metabolic process (GO:0030205)2.29890588
149negative regulation of smooth muscle cell migration (GO:0014912)2.28271354
150peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.28036274
151negative regulation of homotypic cell-cell adhesion (GO:0034111)2.25728188
152virion attachment to host cell (GO:0019062)2.24492498
153adhesion of symbiont to host cell (GO:0044650)2.24492498

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.57734795
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.76739261
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.60062806
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.46479113
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34976111
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.34785304
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.34766827
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34414082
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.24836414
10* CJUN_26792858_Chip-Seq_BT549_Human2.21065490
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.14917075
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.09899502
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06775358
14SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.98992005
15SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.98992005
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.81942416
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75022633
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70142321
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67742197
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.65419979
21* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.65077921
22PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64554601
23CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64189067
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.62741702
25NRF2_20460467_ChIP-Seq_MEFs_Mouse1.62110990
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.62110990
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59921001
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55224633
29SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.54633092
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.51803463
31SOX2_20726797_ChIP-Seq_SW620_Human1.51211817
32TP53_18474530_ChIP-ChIP_U2OS_Human1.49076116
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46837906
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45505877
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44962112
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44294887
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.42296863
38* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41970175
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.38669767
40* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38453143
41AHR_22903824_ChIP-Seq_MCF-7_Human1.34793042
42BRD4_25478319_ChIP-Seq_HGPS_Human1.33967339
43* ELK3_25401928_ChIP-Seq_HUVEC_Human1.31742576
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30178750
45* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29906398
46TP53_20018659_ChIP-ChIP_R1E_Mouse1.27594266
47CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27086291
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26996779
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24706227
50UBF1/2_26484160_Chip-Seq_HMECs_Human1.24619902
51* ATF3_27146783_Chip-Seq_COLON_Human1.22657257
52KLF5_25053715_ChIP-Seq_YYC3_Human1.22475411
53TP63_23658742_ChIP-Seq_EP156T_Human1.19734107
54KDM2B_26808549_Chip-Seq_K562_Human1.19441036
55* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19102040
56* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19028191
57RACK7_27058665_Chip-Seq_MCF-7_Human1.18247019
58TP53_16413492_ChIP-PET_HCT116_Human1.18233200
59RXR_22108803_ChIP-Seq_LS180_Human1.17873188
60ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17804407
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.17011377
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16641871
63RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16641871
64* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13373273
65NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12254276
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10915527
67* TP63_22573176_ChIP-Seq_HFKS_Human1.10595150
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10002136
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09964409
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09577188
71CLOCK_20551151_ChIP-Seq_293T_Human1.08810232
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07952236
73AR_21909140_ChIP-Seq_LNCAP_Human1.07894558
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05870118
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02288310
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02219206
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02143058
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01737272
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.01590252
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.00926860
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00620687
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.00605551
83AR_21572438_ChIP-Seq_LNCaP_Human1.00150703
84ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00055799
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99552372
86CDX2_20551321_ChIP-Seq_CACO-2_Human0.98682506
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98600227
88TP53_23651856_ChIP-Seq_MEFs_Mouse0.97809276
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97618353
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97530179
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.97239273
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96631592
93ZNF263_19887448_ChIP-Seq_K562_Human0.96408874
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95984303
95TET1_21490601_ChIP-Seq_MESCs_Mouse0.95974238
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94390640
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94065184
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93916962
99GATA3_24758297_ChIP-Seq_MCF-7_Human0.93034016
100MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92947509
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92311388
102SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92287601
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91763637
104BCAT_22108803_ChIP-Seq_LS180_Human0.91730266
105RUNX1_27514584_Chip-Seq_MCF-7_Human0.90569735
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89178551
107GATA6_25053715_ChIP-Seq_YYC3_Human0.88916530
108WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87625606
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.86971750
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.86971750
111TP53_22127205_ChIP-Seq_IMR90_Human0.86601561
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85443749
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85353026
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84509286
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84489619
116NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83788934
117EGR1_19374776_ChIP-ChIP_THP-1_Human0.83496007
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83051988
119VDR_24787735_ChIP-Seq_THP-1_Human0.82769439
120LXR_22292898_ChIP-Seq_THP-1_Human0.82727390
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81996556
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80764818
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80541121
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79756099
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79580061
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74998007
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74552049
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.74542846
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.72304704
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71665416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.28844936
2MP0005275_abnormal_skin_tensile5.83818032
3MP0003705_abnormal_hypodermis_morpholog4.17420925
4MP0002796_impaired_skin_barrier3.25729392
5MP0005503_abnormal_tendon_morphology3.22323300
6MP0004858_abnormal_nervous_system3.08906329
7MP0002060_abnormal_skin_morphology2.98089998
8MP0001958_emphysema2.71349835
9MP0003279_aneurysm2.61070685
10MP0003566_abnormal_cell_adhesion2.55356831
11MP0003941_abnormal_skin_development2.41156739
12MP0005409_darkened_coat_color2.37674594
13MP0005257_abnormal_intraocular_pressure2.31132990
14MP0005623_abnormal_meninges_morphology2.29403079
15MP0010234_abnormal_vibrissa_follicle2.21737155
16MP0005023_abnormal_wound_healing2.04201261
17MP0005501_abnormal_skin_physiology2.01311914
18MP0003045_fibrosis2.00006138
19MP0010771_integument_phenotype1.88535390
20MP0009780_abnormal_chondrocyte_physiolo1.88113079
21MP0010352_gastrointestinal_tract_polyps1.80938155
22MP0000569_abnormal_digit_pigmentation1.79880774
23MP0003091_abnormal_cell_migration1.79562259
24MP0004272_abnormal_basement_membrane1.78727181
25MP0001299_abnormal_eye_distance/1.69806098
26MP0004947_skin_inflammation1.69507397
27MP0002735_abnormal_chemical_nociception1.69498944
28MP0002254_reproductive_system_inflammat1.68835511
29MP0003453_abnormal_keratinocyte_physiol1.63565581
30MP0000372_irregular_coat_pigmentation1.63043082
31MP0005508_abnormal_skeleton_morphology1.56419313
32MP0003191_abnormal_cellular_cholesterol1.52675961
33MP0001243_abnormal_dermal_layer1.50099581
34MP0001348_abnormal_lacrimal_gland1.48520501
35MP0009053_abnormal_anal_canal1.48330141
36MP0001216_abnormal_epidermal_layer1.47527036
37MP0000566_synostosis1.44266478
38MP0002877_abnormal_melanocyte_morpholog1.42235643
39MP0005171_absent_coat_pigmentation1.41560548
40MP0000383_abnormal_hair_follicle1.40521885
41MP0000751_myopathy1.38710291
42MP0000579_abnormal_nail_morphology1.37584050
43MP0009384_cardiac_valve_regurgitation1.32475076
44MP0000749_muscle_degeneration1.30874996
45MP0001849_ear_inflammation1.25579938
46MP0000537_abnormal_urethra_morphology1.23876040
47MP0006054_spinal_hemorrhage1.20368455
48MP0002108_abnormal_muscle_morphology1.19970686
49MP0001542_abnormal_bone_strength1.19394453
50MP0010678_abnormal_skin_adnexa1.18790582
51MP0005058_abnormal_lysosome_morphology1.17543758
52MP0002896_abnormal_bone_mineralization1.13853777
53MP0000733_abnormal_muscle_development1.13318979
54MP0000427_abnormal_hair_cycle1.09352047
55MP0002295_abnormal_pulmonary_circulatio1.09137207
56MP0000013_abnormal_adipose_tissue1.07916989
57MP0010368_abnormal_lymphatic_system1.06680067
58MP0004381_abnormal_hair_follicle1.05331822
59MP0003300_gastrointestinal_ulcer1.05296283
60MP0002998_abnormal_bone_remodeling1.05051529
61MP0002168_other_aberrant_phenotype1.04893723
62MP0000377_abnormal_hair_follicle1.02729913
63MP0000003_abnormal_adipose_tissue1.02558146
64MP0005390_skeleton_phenotype1.01605552
65MP0005076_abnormal_cell_differentiation1.00444275
66MP0009379_abnormal_foot_pigmentation0.99562387
67MP0004233_abnormal_muscle_weight0.99112462
68MP0009931_abnormal_skin_appearance0.98432888
69MP0000762_abnormal_tongue_morphology0.97747139
70MP0000767_abnormal_smooth_muscle0.97296737
71MP0000538_abnormal_urinary_bladder0.93525852
72MP0000647_abnormal_sebaceous_gland0.89046271
73MP0001191_abnormal_skin_condition0.88407866
74MP0004782_abnormal_surfactant_physiolog0.87905374
75MP0004264_abnormal_extraembryonic_tissu0.87668175
76MP0003448_altered_tumor_morphology0.87346875
77MP0005197_abnormal_uvea_morphology0.86799500
78MP0000858_altered_metastatic_potential0.85591002
79MP0008260_abnormal_autophagy0.85494887
80MP0001533_abnormal_skeleton_physiology0.84654312
81MP0000367_abnormal_coat/_hair0.83652682
82MP0000534_abnormal_ureter_morphology0.83007861
83MP0003283_abnormal_digestive_organ0.82400422
84MP0003172_abnormal_lysosome_physiology0.82294989
85MP0002234_abnormal_pharynx_morphology0.82294677
86MP0010030_abnormal_orbit_morphology0.82229819
87MP0006138_congestive_heart_failure0.81887920
88MP0009250_abnormal_appendicular_skeleto0.81732551
89MP0000467_abnormal_esophagus_morphology0.80641519
90MP0003385_abnormal_body_wall0.78995147
91MP0002736_abnormal_nociception_after0.76399508
92MP0001270_distended_abdomen0.74751648
93MP0000750_abnormal_muscle_regeneration0.74683468
94MP0002933_joint_inflammation0.74668327
95MP0000759_abnormal_skeletal_muscle0.74169883
96MP0001879_abnormal_lymphatic_vessel0.73420063
97MP0002115_abnormal_skeleton_extremities0.73160561
98MP0000604_amyloidosis0.72532814
99MP0004185_abnormal_adipocyte_glucose0.70257815
100MP0010307_abnormal_tumor_latency0.70252594
101MP0005595_abnormal_vascular_smooth0.68551005
102MP0003755_abnormal_palate_morphology0.67326767
103MP0001968_abnormal_touch/_nociception0.67305123
104MP0002098_abnormal_vibrissa_morphology0.67147733
105MP0004883_abnormal_blood_vessel0.66965212
106MP0003950_abnormal_plasma_membrane0.66812004
107MP0000428_abnormal_craniofacial_morphol0.66726059
108MP0001851_eye_inflammation0.65686761
109MP0003795_abnormal_bone_structure0.64853046
110MP0000627_abnormal_mammary_gland0.63625110
111MP0009278_abnormal_bone_marrow0.63519745
112MP0000432_abnormal_head_morphology0.63003433
113MP0005193_abnormal_anterior_eye0.62370087
114MP0005375_adipose_tissue_phenotype0.62165685
115MP0005621_abnormal_cell_physiology0.59483073
116MP0002177_abnormal_outer_ear0.59399229
117MP0000747_muscle_weakness0.58935857
118MP0004087_abnormal_muscle_fiber0.58813029
119MP0001346_abnormal_lacrimal_gland0.58452487
120MP0005174_abnormal_tail_pigmentation0.58193547
121MP0005164_abnormal_response_to0.58147120
122MP0001340_abnormal_eyelid_morphology0.56881532
123MP0000163_abnormal_cartilage_morphology0.56505858
124MP0002282_abnormal_trachea_morphology0.55682725
125MP0000015_abnormal_ear_pigmentation0.54724674
126MP0005165_increased_susceptibility_to0.54473860
127MP0002006_tumorigenesis0.54339407
128MP0005248_abnormal_Harderian_gland0.53019221
129MP0004134_abnormal_chest_morphology0.52760947
130MP0001784_abnormal_fluid_regulation0.51538877
131MP0004084_abnormal_cardiac_muscle0.51212604
132MP0001915_intracranial_hemorrhage0.50390352

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.69883885
2Protrusio acetabuli (HP:0003179)5.68984911
3Abnormality of nail color (HP:0100643)5.24175493
4Onycholysis (HP:0001806)5.07069032
5Ulnar claw (HP:0001178)4.68757785
6Atrophic scars (HP:0001075)4.51910955
7Fragile nails (HP:0001808)4.26220832
8Fragile skin (HP:0001030)4.18398337
9Ankle contracture (HP:0006466)4.08262670
10Increased connective tissue (HP:0009025)3.87883303
11Hyporeflexia of lower limbs (HP:0002600)3.87305726
12Cervical subluxation (HP:0003308)3.74157185
13Broad metatarsal (HP:0001783)3.55522946
14Vertebral compression fractures (HP:0002953)3.42131364
15Distal lower limb muscle weakness (HP:0009053)3.40478428
16Shallow orbits (HP:0000586)3.21699232
17Cerebral aneurysm (HP:0004944)3.20496321
18Wrist flexion contracture (HP:0001239)3.11882623
19Alopecia of scalp (HP:0002293)3.10685492
20Aortic dissection (HP:0002647)3.03166928
21Peritonitis (HP:0002586)3.02737037
22Arterial tortuosity (HP:0005116)2.93796409
23Broad face (HP:0000283)2.93726246
24Dilatation of the ascending aorta (HP:0005111)2.91708420
25Aortic aneurysm (HP:0004942)2.90255514
26Abnormal blistering of the skin (HP:0008066)2.89153204
27Thick nail (HP:0001805)2.84868990
28Soft skin (HP:0000977)2.83902702
29Osteolytic defects of the hand bones (HP:0009699)2.80864286
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.80864286
31Right ventricular cardiomyopathy (HP:0011663)2.80416049
32Spinal rigidity (HP:0003306)2.80037705
33Distal lower limb amyotrophy (HP:0008944)2.78384300
34Type 1 muscle fiber predominance (HP:0003803)2.70215369
35Corneal erosion (HP:0200020)2.70018248
36Wormian bones (HP:0002645)2.68137031
37Selective tooth agenesis (HP:0001592)2.65890301
38Distal arthrogryposis (HP:0005684)2.64275532
39Follicular hyperkeratosis (HP:0007502)2.61938505
40Ridged nail (HP:0001807)2.60502493
41Ankyloglossia (HP:0010296)2.58154840
42Segmental peripheral demyelination/remyelination (HP:0003481)2.57963199
43Erythema (HP:0010783)2.56126706
44Woolly hair (HP:0002224)2.55655986
45Difficulty climbing stairs (HP:0003551)2.51155028
46Pili torti (HP:0003777)2.50599076
47Foot dorsiflexor weakness (HP:0009027)2.48051330
48Hypoplasia of dental enamel (HP:0006297)2.42623026
49Hypotrichosis (HP:0001006)2.42617046
50Congenital ichthyosiform erythroderma (HP:0007431)2.41977957
51Abnormal hemoglobin (HP:0011902)2.41475274
52Neonatal respiratory distress (HP:0002643)2.41040493
53Genu recurvatum (HP:0002816)2.40961104
54Camptodactyly of toe (HP:0001836)2.40741389
55Bladder diverticulum (HP:0000015)2.40171515
56Milia (HP:0001056)2.38637705
57Abnormality of oral frenula (HP:0000190)2.37361716
58Submucous cleft hard palate (HP:0000176)2.34357251
59Knee flexion contracture (HP:0006380)2.34101364
60Mitral valve prolapse (HP:0001634)2.33809207
61Short nail (HP:0001799)2.32416229
62Abnormal hair laboratory examination (HP:0003328)2.30405196
63Pterygium (HP:0001059)2.28533133
64Neonatal short-limb short stature (HP:0008921)2.26988149
65Long toe (HP:0010511)2.24540236
66Plantar hyperkeratosis (HP:0007556)2.24537252
67Natal tooth (HP:0000695)2.22749515
68Ectropion (HP:0000656)2.22297254
69Entropion (HP:0000621)2.22097422
70Erythroderma (HP:0001019)2.20803589
71Blue sclerae (HP:0000592)2.19996416
72Sparse scalp hair (HP:0002209)2.15894194
73Steppage gait (HP:0003376)2.15185773
74Upper limb amyotrophy (HP:0009129)2.15042076
75Distal upper limb amyotrophy (HP:0007149)2.15042076
76Lower limb amyotrophy (HP:0007210)2.14226567
77Abnormality of the foot musculature (HP:0001436)2.13850306
78Increased variability in muscle fiber diameter (HP:0003557)2.11663642
79Abnormality of the distal phalanges of the toes (HP:0010182)2.11523451
80Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.11330187
81Hammertoe (HP:0001765)2.09938318
82Abnormality of the axillary hair (HP:0100134)2.07297544
83Abnormality of secondary sexual hair (HP:0009888)2.07297544
84Sparse eyelashes (HP:0000653)2.06692382
85Elbow flexion contracture (HP:0002987)2.06389267
86Areflexia of lower limbs (HP:0002522)2.03957015
87Coxa vara (HP:0002812)2.03897457
88Overgrowth (HP:0001548)2.03538927
89Flexion contracture of toe (HP:0005830)2.02147436
90Joint contractures involving the joints of the feet (HP:0100492)2.02147436
91Palmoplantar hyperkeratosis (HP:0000972)2.01582439
92Increased IgE level (HP:0003212)2.01082836
93Reduced subcutaneous adipose tissue (HP:0003758)2.00202450
94Thin bony cortex (HP:0002753)1.99949209
95Upper limb muscle weakness (HP:0003484)1.99576621
96Bowel diverticulosis (HP:0005222)1.99231660
97Neonatal death (HP:0003811)1.99161782
98Lip pit (HP:0100267)1.98571534
99Mildly elevated creatine phosphokinase (HP:0008180)1.98099947
100Spondylolisthesis (HP:0003302)1.97967906
101Scapular winging (HP:0003691)1.97496891
102Abnormality of dentin (HP:0010299)1.96901069
103Advanced eruption of teeth (HP:0006288)1.96897336
104Hyperextensible skin (HP:0000974)1.96572659
105Wide anterior fontanel (HP:0000260)1.94492552
106Popliteal pterygium (HP:0009756)1.93994556
107Hyperacusis (HP:0010780)1.92974839
108Absent phalangeal crease (HP:0006109)1.92618544
109Palmoplantar keratoderma (HP:0000982)1.91075905
110Absent frontal sinuses (HP:0002688)1.88691337
111Vascular tortuosity (HP:0004948)1.88664759
112Limited hip movement (HP:0008800)1.88271015
113Spinal cord compression (HP:0002176)1.88080203
114Flat acetabular roof (HP:0003180)1.87502792
115Ventricular tachycardia (HP:0004756)1.87356683
116Thoracolumbar scoliosis (HP:0002944)1.87260019
117Slender build (HP:0001533)1.86000398
118Down-sloping shoulders (HP:0200021)1.85764312
119Mitral stenosis (HP:0001718)1.84555626
120Nail dystrophy (HP:0008404)1.84361608
121Abnormality of skeletal muscle fiber size (HP:0012084)1.84097536
122Palmar hyperkeratosis (HP:0010765)1.83685071
123Cardiovascular calcification (HP:0011915)1.83466195
124Axonal loss (HP:0003447)1.83354523
125Absent eyelashes (HP:0000561)1.82544728
126Abnormality of the salivary glands (HP:0010286)1.82015860
127Aplasia cutis congenita (HP:0001057)1.81452578
128Syringomyelia (HP:0003396)1.80829429
129Spinal cord lesions (HP:0100561)1.80829429
130Abnormality of the distal phalanx of the thumb (HP:0009617)1.80189795
131Aortic regurgitation (HP:0001659)1.79146153
132Decreased motor nerve conduction velocity (HP:0003431)1.78918490
133Round ear (HP:0100830)1.78436039
134Vertebral arch anomaly (HP:0008438)1.77124246
135Ovoid vertebral bodies (HP:0003300)1.75985401
136Abnormal ossification of hand bones (HP:0005921)1.75897354
137Acanthosis nigricans (HP:0000956)1.73841994
138Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.73203882
139Difficulty running (HP:0009046)1.72911296
140Tibial bowing (HP:0002982)1.72750638
141Biconcave vertebral bodies (HP:0004586)1.71958303
142Achilles tendon contracture (HP:0001771)1.71687046
143Onion bulb formation (HP:0003383)1.71602284
144Hypercortisolism (HP:0001578)1.71489728
145Ulnar bowing (HP:0003031)1.71367422
146Turricephaly (HP:0000262)1.70678295
147Hypoplastic labia majora (HP:0000059)1.70099633
148Anonychia (HP:0001798)1.69226729
149Hypoplasia of the iris (HP:0007676)1.68044313
150Mitral regurgitation (HP:0001653)1.65062102
151Dry hair (HP:0011359)1.63968129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK34.20843676
2LATS23.52823137
3TTN3.28110512
4DDR22.97554235
5LMTK22.82145617
6TRPM72.81084427
7MST1R2.62847242
8FER2.52554526
9TRIB32.31002170
10NTRK12.20045451
11PDGFRA2.18753185
12EPHA32.03781632
13PBK1.93377252
14ERN11.81744286
15MAP3K21.75757168
16MAP3K61.75039408
17PAK41.65481192
18NEK91.64262281
19EPHB21.60446958
20LIMK11.60112095
21IRAK31.58333748
22LRRK21.54504519
23PIM21.53701257
24RIPK11.53202930
25BMX1.50897553
26PKN21.49712255
27MAP3K91.47326693
28MET1.38884488
29ICK1.34946776
30LATS11.31820380
31ERBB41.30973851
32CDK121.29432015
33FLT31.26238497
34MAP2K11.26053026
35PTK21.25440017
36RET1.24085453
37MINK11.22288535
38EPHB11.22225411
39MAP3K31.20453090
40PTK61.16704808
41KSR21.16149968
42JAK11.14265466
43RPS6KB21.13979838
44TGFBR11.13478881
45MOS1.12180637
46MYLK1.12174260
47SIK11.11836975
48WNK11.09301294
49EEF2K1.03943324
50SCYL21.02645427
51MATK1.02490557
52FGFR30.98121532
53RPS6KA20.97273888
54MAP3K10.97157370
55PDGFRB0.96042609
56TGFBR20.93828399
57RIPK40.91586240
58ROCK10.90898831
59PAK20.88202480
60FGFR40.86347274
61PRKD20.86035900
62TBK10.85725627
63SMG10.84650246
64TAOK10.78216677
65BLK0.78051654
66MAP2K20.77943528
67PHKG10.77282434
68PHKG20.77282434
69CAMK1D0.76358481
70PAK60.73948302
71STK240.72537446
72PRPF4B0.71949512
73MTOR0.71633140
74ARAF0.68150841
75MAPKAPK50.68088780
76STK38L0.67567962
77NTRK30.65943048
78FGFR10.65648241
79PAK30.64174092
80TESK10.63891143
81MAP3K140.63376425
82PRKG20.63157278
83KIT0.62643890
84PIK3CG0.60555194
85CDC42BPA0.60497848
86PRKCH0.60434003
87EPHA20.60261391
88PRKD10.60222265
89ADRBK10.58882346
90MARK30.58594632
91MAPKAPK20.57348669
92CDK80.57159726
93TYK20.54819948
94MST40.54722385
95PRKD30.52307228
96ROCK20.52210670
97MARK20.51426502
98DMPK0.51188860
99MELK0.51130195
100MAP3K120.50825277
101PTK2B0.50193332
102HCK0.49406391
103GSK3A0.49214163
104SRC0.48591103
105ABL20.48310261
106RPS6KA40.47934068
107STK30.47390454
108JAK30.46925576
109MAP3K110.46762252
110ERBB30.45428153
111PRKCE0.45299040
112STK380.45235318
113MAPK110.44245985
114CAMKK10.44147769
115MAP3K70.43979469
116CAMKK20.43313372
117SGK30.42407543
118INSR0.41496976
119IKBKB0.37770350
120CAMK2G0.37286520
121MAP2K30.36723718
122NME20.34044014
123ILK0.32281594
124RPS6KC10.31009714
125RPS6KL10.31009714
126STK100.30967980
127DAPK30.28564466
128PRKCI0.27932370
129EPHA40.26396076
130MAP3K80.22977526
131PRKAA20.22943037
132MAPK70.22744254
133CAMK2B0.22244662
134KSR10.22123316
135CDK90.21605571

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.69324001
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.98559158
3Amoebiasis_Homo sapiens_hsa051461.88523550
4Focal adhesion_Homo sapiens_hsa045101.83981173
5Proteoglycans in cancer_Homo sapiens_hsa052051.79067621
6Glycosaminoglycan degradation_Homo sapiens_hsa005311.77940432
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.70807868
8Phagosome_Homo sapiens_hsa041451.69756333
9Lysosome_Homo sapiens_hsa041421.67796927
10Malaria_Homo sapiens_hsa051441.66761142
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.65010592
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52904700
13Melanoma_Homo sapiens_hsa052181.52902531
14Salmonella infection_Homo sapiens_hsa051321.51153825
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50498615
16Bladder cancer_Homo sapiens_hsa052191.46530854
17Adherens junction_Homo sapiens_hsa045201.43137874
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42545323
19Sphingolipid metabolism_Homo sapiens_hsa006001.34256648
20Dorso-ventral axis formation_Homo sapiens_hsa043201.32363561
21Glioma_Homo sapiens_hsa052141.31791167
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31019248
23Tuberculosis_Homo sapiens_hsa051521.27039691
24Notch signaling pathway_Homo sapiens_hsa043301.25750646
25Renal cell carcinoma_Homo sapiens_hsa052111.25077251
26Protein digestion and absorption_Homo sapiens_hsa049741.24748771
27Toxoplasmosis_Homo sapiens_hsa051451.23959259
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.23796919
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.23479253
30Chronic myeloid leukemia_Homo sapiens_hsa052201.22848262
31Osteoclast differentiation_Homo sapiens_hsa043801.17453750
32VEGF signaling pathway_Homo sapiens_hsa043701.16549680
33Leishmaniasis_Homo sapiens_hsa051401.16427489
34TNF signaling pathway_Homo sapiens_hsa046681.12727366
35Apoptosis_Homo sapiens_hsa042101.09700761
36Dilated cardiomyopathy_Homo sapiens_hsa054141.09647221
37Small cell lung cancer_Homo sapiens_hsa052221.09436237
38Rheumatoid arthritis_Homo sapiens_hsa053231.09259766
39Circadian rhythm_Homo sapiens_hsa047101.09157065
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08980085
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08562699
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08281286
43GnRH signaling pathway_Homo sapiens_hsa049121.06982601
44MicroRNAs in cancer_Homo sapiens_hsa052061.06758632
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.06667061
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05310027
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03886768
48PI3K-Akt signaling pathway_Homo sapiens_hsa041511.03441597
49Pertussis_Homo sapiens_hsa051331.03413556
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01787216
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01660360
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99632126
53Endocytosis_Homo sapiens_hsa041440.98800257
54Platelet activation_Homo sapiens_hsa046110.98284877
55Galactose metabolism_Homo sapiens_hsa000520.98123736
56Hippo signaling pathway_Homo sapiens_hsa043900.97405288
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.97329215
58Shigellosis_Homo sapiens_hsa051310.97036829
59Synaptic vesicle cycle_Homo sapiens_hsa047210.95999616
60Axon guidance_Homo sapiens_hsa043600.95447832
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94515887
62TGF-beta signaling pathway_Homo sapiens_hsa043500.94271693
63Rap1 signaling pathway_Homo sapiens_hsa040150.91192443
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.91179381
65Pancreatic cancer_Homo sapiens_hsa052120.89640837
66Hedgehog signaling pathway_Homo sapiens_hsa043400.88974138
67Prolactin signaling pathway_Homo sapiens_hsa049170.88043371
68Collecting duct acid secretion_Homo sapiens_hsa049660.87323265
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86531208
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84964830
71Inositol phosphate metabolism_Homo sapiens_hsa005620.84272658
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83958308
73ErbB signaling pathway_Homo sapiens_hsa040120.82938280
74Ras signaling pathway_Homo sapiens_hsa040140.82744263
75Endometrial cancer_Homo sapiens_hsa052130.82675416
76Choline metabolism in cancer_Homo sapiens_hsa052310.81934923
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80205801
78Melanogenesis_Homo sapiens_hsa049160.79905593
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79366201
80Viral myocarditis_Homo sapiens_hsa054160.77318306
81mTOR signaling pathway_Homo sapiens_hsa041500.77129548
82Thyroid cancer_Homo sapiens_hsa052160.75094388
83Non-small cell lung cancer_Homo sapiens_hsa052230.73749023
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73101943
85Estrogen signaling pathway_Homo sapiens_hsa049150.72970954
86Prostate cancer_Homo sapiens_hsa052150.71299742
87Basal cell carcinoma_Homo sapiens_hsa052170.70609498
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.69830806
89Acute myeloid leukemia_Homo sapiens_hsa052210.69589478
90Insulin signaling pathway_Homo sapiens_hsa049100.68404627
91Fructose and mannose metabolism_Homo sapiens_hsa000510.68272517
92Pathways in cancer_Homo sapiens_hsa052000.68099712
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67729557
94Insulin resistance_Homo sapiens_hsa049310.67144865
95HIF-1 signaling pathway_Homo sapiens_hsa040660.66461431
96Tight junction_Homo sapiens_hsa045300.65286969
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64803299
98Hepatitis C_Homo sapiens_hsa051600.64783178
99p53 signaling pathway_Homo sapiens_hsa041150.64494171
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.64470427
101Caffeine metabolism_Homo sapiens_hsa002320.63506000
102Vibrio cholerae infection_Homo sapiens_hsa051100.62440423
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61945173
104MAPK signaling pathway_Homo sapiens_hsa040100.61161506
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.60656307
106Prion diseases_Homo sapiens_hsa050200.60351436
107Glucagon signaling pathway_Homo sapiens_hsa049220.60103009
108Other glycan degradation_Homo sapiens_hsa005110.59944288
109Vitamin B6 metabolism_Homo sapiens_hsa007500.59654881
110Ovarian steroidogenesis_Homo sapiens_hsa049130.58664265
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58059634
112Wnt signaling pathway_Homo sapiens_hsa043100.57684458
113AMPK signaling pathway_Homo sapiens_hsa041520.57502811
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.55947669
115Salivary secretion_Homo sapiens_hsa049700.55911489
116Pentose phosphate pathway_Homo sapiens_hsa000300.55233969
117Hepatitis B_Homo sapiens_hsa051610.54719242
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54710621
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54096450
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53858611
121Gap junction_Homo sapiens_hsa045400.52975890
122Long-term depression_Homo sapiens_hsa047300.49802967
123Colorectal cancer_Homo sapiens_hsa052100.45543577
124Renin secretion_Homo sapiens_hsa049240.43464886

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