AHR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.88108501
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.88108501
3peptidyl-glutamic acid carboxylation (GO:0017187)4.73480579
4protein carboxylation (GO:0018214)4.73480579
5aromatic amino acid family catabolic process (GO:0009074)4.53159911
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.52895014
7L-phenylalanine metabolic process (GO:0006558)4.52895014
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.52889463
9negative regulation of fibrinolysis (GO:0051918)4.46797454
10urea cycle (GO:0000050)4.40580842
11urea metabolic process (GO:0019627)4.40580842
12indolalkylamine catabolic process (GO:0046218)4.30755278
13tryptophan catabolic process (GO:0006569)4.30755278
14indole-containing compound catabolic process (GO:0042436)4.30755278
15kynurenine metabolic process (GO:0070189)4.22928755
16regulation of fibrinolysis (GO:0051917)4.22821398
17complement activation, alternative pathway (GO:0006957)4.20642121
18tryptophan metabolic process (GO:0006568)4.15417066
19bile acid biosynthetic process (GO:0006699)4.13258494
20high-density lipoprotein particle remodeling (GO:0034375)4.12201294
21regulation of protein activation cascade (GO:2000257)4.10680977
22nitrogen cycle metabolic process (GO:0071941)3.93853958
23phospholipid efflux (GO:0033700)3.88372595
24regulation of complement activation (GO:0030449)3.85719962
25alpha-linolenic acid metabolic process (GO:0036109)3.79431073
26reverse cholesterol transport (GO:0043691)3.77026530
27fibrinolysis (GO:0042730)3.70729833
28regulation of triglyceride catabolic process (GO:0010896)3.60484247
29positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.60323171
30negative regulation of cholesterol transport (GO:0032375)3.58498727
31negative regulation of sterol transport (GO:0032372)3.58498727
32response to peptidoglycan (GO:0032494)3.53691743
33plasma lipoprotein particle clearance (GO:0034381)3.53146676
34sulfur amino acid catabolic process (GO:0000098)3.52255973
35glyoxylate metabolic process (GO:0046487)3.50855870
36regulation of cholesterol esterification (GO:0010872)3.48208554
37protein-lipid complex remodeling (GO:0034368)3.46518291
38macromolecular complex remodeling (GO:0034367)3.46518291
39plasma lipoprotein particle remodeling (GO:0034369)3.46518291
40cellular extravasation (GO:0045123)3.46308053
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.46305050
42cysteine metabolic process (GO:0006534)3.46067427
43bile acid metabolic process (GO:0008206)3.45703367
44regulation of cholesterol homeostasis (GO:2000188)3.43146761
45cholesterol efflux (GO:0033344)3.35630364
46acute-phase response (GO:0006953)3.31077896
47tyrosine metabolic process (GO:0006570)3.30962210
48epoxygenase P450 pathway (GO:0019373)3.28017412
49homocysteine metabolic process (GO:0050667)3.26991858
50growth hormone receptor signaling pathway (GO:0060396)3.23479677
51cellular glucuronidation (GO:0052695)3.23073525
52plasma lipoprotein particle assembly (GO:0034377)3.22978348
53response to muramyl dipeptide (GO:0032495)3.22043478
54amino-acid betaine metabolic process (GO:0006577)3.16828074
55acylglycerol homeostasis (GO:0055090)3.15440953
56triglyceride homeostasis (GO:0070328)3.15440953
57positive regulation of lipid catabolic process (GO:0050996)3.15355605
58surfactant homeostasis (GO:0043129)3.15209170
59aromatic amino acid family metabolic process (GO:0009072)3.14218241
60dicarboxylic acid biosynthetic process (GO:0043650)3.13273764
61negative regulation of lipase activity (GO:0060192)3.11172513
62negative regulation of interleukin-12 production (GO:0032695)3.05467605
63phospholipid homeostasis (GO:0055091)3.03777630
64protein localization to endosome (GO:0036010)3.01042418
65low-density lipoprotein particle remodeling (GO:0034374)3.00553397
66serine family amino acid catabolic process (GO:0009071)3.00161159
67indolalkylamine metabolic process (GO:0006586)2.99817970
68positive regulation of blood coagulation (GO:0030194)2.98846903
69positive regulation of hemostasis (GO:1900048)2.98846903
70bile acid and bile salt transport (GO:0015721)2.97911614
71hypotonic response (GO:0006971)2.96791547
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96786215
73detection of molecule of bacterial origin (GO:0032490)2.96495174
74protein-lipid complex assembly (GO:0065005)2.93824000
75cell adhesion mediated by integrin (GO:0033627)2.93075695
76uronic acid metabolic process (GO:0006063)2.92576554
77glucuronate metabolic process (GO:0019585)2.92576554
78lipoprotein metabolic process (GO:0042157)2.92014242
79positive regulation of fatty acid beta-oxidation (GO:0032000)2.91528958
80cellular biogenic amine catabolic process (GO:0042402)2.91353131
81amine catabolic process (GO:0009310)2.91353131
82detection of other organism (GO:0098543)2.91110796
83positive regulation of triglyceride lipase activity (GO:0061365)2.90495642
84positive regulation of lipoprotein lipase activity (GO:0051006)2.90495642
85positive regulation of gamma-delta T cell activation (GO:0046645)2.88046915
86membrane raft organization (GO:0031579)2.86569275
87protein activation cascade (GO:0072376)2.85292569
88cholesterol homeostasis (GO:0042632)2.85000419
89complement activation (GO:0006956)2.82886443
90sterol homeostasis (GO:0055092)2.82632090
91positive regulation of coagulation (GO:0050820)2.82600852
92cellular response to ethanol (GO:0071361)2.82522942
93plasma lipoprotein particle organization (GO:0071827)2.82414812
94negative regulation of blood coagulation (GO:0030195)2.81516119
95negative regulation of hemostasis (GO:1900047)2.81516119
96embryonic process involved in female pregnancy (GO:0060136)2.81220214
97pinocytosis (GO:0006907)2.80382190
98opsonization (GO:0008228)2.80241326
99alpha-amino acid catabolic process (GO:1901606)2.78034140
100cholesterol transport (GO:0030301)2.75468183
101sterol transport (GO:0015918)2.75468183
102response to growth hormone (GO:0060416)2.75089077
103low-density lipoprotein particle clearance (GO:0034383)2.75079971
104benzene-containing compound metabolic process (GO:0042537)2.74212456
105regulation of interleukin-12 biosynthetic process (GO:0045075)2.71958841
106regulation of plasminogen activation (GO:0010755)2.71339632
107complement activation, classical pathway (GO:0006958)2.70977716
108negative regulation of fatty acid transport (GO:2000192)2.70244069
109regulation of bile acid biosynthetic process (GO:0070857)2.69184232
110very-low-density lipoprotein particle assembly (GO:0034379)2.68772516
111neutrophil activation involved in immune response (GO:0002283)2.68462159
112protein-lipid complex subunit organization (GO:0071825)2.68103483
113cellular response to growth hormone stimulus (GO:0071378)2.67738949
114T-helper 1 type immune response (GO:0042088)2.67631710
115arginine metabolic process (GO:0006525)2.67454238
116germinal center formation (GO:0002467)2.66768448
117blood coagulation, intrinsic pathway (GO:0007597)2.66634489
118detection of external biotic stimulus (GO:0098581)2.65918203
119negative regulation of coagulation (GO:0050819)2.65523258
120imidazole-containing compound metabolic process (GO:0052803)2.64903143
121drug catabolic process (GO:0042737)2.64769543
122lipopolysaccharide-mediated signaling pathway (GO:0031663)2.64479322
123antigen processing and presentation of endogenous antigen (GO:0019883)2.64149821
124macrophage activation involved in immune response (GO:0002281)2.63838009
125response to laminar fluid shear stress (GO:0034616)2.61060913
126wound healing, spreading of epidermal cells (GO:0035313)2.60471913
127skin morphogenesis (GO:0043589)2.58071776
128antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.57134035
129cellular response to thyroid hormone stimulus (GO:0097067)2.56751375
130antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.56717798
131detection of biotic stimulus (GO:0009595)2.56465491
132detection of bacterium (GO:0016045)2.55276932
133negative regulation of erythrocyte differentiation (GO:0045647)2.53654246
134positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.49867876
135regulation of dendritic cell antigen processing and presentation (GO:0002604)2.48597721
136positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.47365546
137positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.47055521
138regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.46240234
139negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.45480986
140negative regulation of cell killing (GO:0031342)2.45480986
141regulation of vitamin D biosynthetic process (GO:0060556)2.43908536
142positive regulation of extracellular matrix organization (GO:1903055)2.43828884
143positive regulation by symbiont of host defense response (GO:0052509)2.42839352
144modulation by symbiont of host defense response (GO:0052031)2.42839352
145modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.42839352
146modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.42839352
147positive regulation by organism of defense response of other organism involved in symbiotic interact2.42839352
148modulation by symbiont of host immune response (GO:0052553)2.42839352
149regulation of macrophage cytokine production (GO:0010935)2.41570020
150oligosaccharide catabolic process (GO:0009313)2.39240966
151positive regulation of leukocyte degranulation (GO:0043302)2.38391717
152negative regulation of interleukin-8 production (GO:0032717)2.36684259
153interleukin-6-mediated signaling pathway (GO:0070102)2.34957822
154negative regulation of complement activation (GO:0045916)2.34419888
155hemidesmosome assembly (GO:0031581)2.32940745
156positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.32501907
157regulation of tolerance induction (GO:0002643)2.32452337
158regulation of T-helper 2 cell differentiation (GO:0045628)2.31199615
159negative regulation of protein activation cascade (GO:2000258)2.30213462
160mRNA transcription (GO:0009299)2.30014766
161negative regulation of interleukin-17 production (GO:0032700)2.29334620
162negative regulation of lipid storage (GO:0010888)2.29210144
163regulation of transforming growth factor beta1 production (GO:0032908)2.28939721
164regulation of gamma-delta T cell activation (GO:0046643)2.28759409
165regulation of interferon-beta biosynthetic process (GO:0045357)2.27937312
166interferon-gamma-mediated signaling pathway (GO:0060333)2.26677678
167iron ion import (GO:0097286)2.26648521
168mature B cell differentiation involved in immune response (GO:0002313)2.25783226
169regulation of integrin activation (GO:0033623)2.24594050
170positive regulation of tolerance induction (GO:0002645)2.21483702
171chemical homeostasis within a tissue (GO:0048875)2.21243397
172regulation of vitamin metabolic process (GO:0030656)2.20147357
173peptide catabolic process (GO:0043171)2.17307751
174immunoglobulin mediated immune response (GO:0016064)2.16690574
175positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.15819162
176regulation of leukocyte degranulation (GO:0043300)2.15529313
177regulation of macrophage chemotaxis (GO:0010758)2.14979321
178macrophage activation (GO:0042116)2.13704127
179negative regulation of humoral immune response (GO:0002921)2.13511726
180regulation of membrane protein ectodomain proteolysis (GO:0051043)2.13165160
181interleukin-1-mediated signaling pathway (GO:0070498)2.13091633
182positive regulation of type 2 immune response (GO:0002830)2.12878807
183platelet-derived growth factor receptor signaling pathway (GO:0048008)2.12556901
184positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.12039980
185negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.11680041
186JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.10190334
187regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.09237270
188regulation of interleukin-8 biosynthetic process (GO:0045414)2.08819235
189regulation of gamma-delta T cell differentiation (GO:0045586)2.06620759
190establishment of endothelial barrier (GO:0061028)2.06487550
191regulation of mast cell degranulation (GO:0043304)2.06449388
192positive regulation of cellular amide metabolic process (GO:0034250)2.06053205
193response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.05854190
194response to host (GO:0075136)2.05854190
195response to host defenses (GO:0052200)2.05854190
196regulation of transforming growth factor beta2 production (GO:0032909)2.05464517
197regulation of necroptotic process (GO:0060544)2.05402150
198positive regulation of macrophage cytokine production (GO:0060907)2.05346654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.88271943
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.29708155
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.04732674
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.32092342
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.21942382
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.14209450
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.51557570
8* FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.35729220
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.29323938
10* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.89882924
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.84215442
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.73317009
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65543265
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.60262900
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.55564324
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.55098470
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.49153956
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.25819487
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24139573
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.16147718
21* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.13164342
22CLOCK_20551151_ChIP-Seq_293T_Human1.93262249
23* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86891892
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.79783442
25GATA1_22025678_ChIP-Seq_K562_Human1.75731044
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67634402
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66797771
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.64556364
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.63537350
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60464941
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59086717
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.56010313
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.52424316
34SCL_19346495_ChIP-Seq_HPC-7_Human1.49822231
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.48931630
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.45225573
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43962307
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43421937
39VDR_24763502_ChIP-Seq_THP-1_Human1.40180182
40* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38337299
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38205446
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37194008
43RUNX_20019798_ChIP-Seq_JUKART_Human1.36601849
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.36245166
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.34264444
46CJUN_26792858_Chip-Seq_BT549_Human1.31472076
47* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30030259
48* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30030259
49* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28678135
50* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28678135
51* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28074534
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27459328
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.27073589
54* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.26991885
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26635794
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26046799
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.25354995
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23981440
59TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.23203553
60SPI1_23127762_ChIP-Seq_K562_Human1.20593983
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19462090
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18575579
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17881814
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16941025
65TCF7_22412390_ChIP-Seq_EML_Mouse1.13225067
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12633208
67* SOX2_20726797_ChIP-Seq_SW620_Human1.12443229
68VDR_24787735_ChIP-Seq_THP-1_Human1.12049734
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09258654
70TP53_16413492_ChIP-PET_HCT116_Human1.09253521
71GATA4_25053715_ChIP-Seq_YYC3_Human1.08646179
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08603864
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08462871
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08435808
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.07673937
76SPI1_23547873_ChIP-Seq_NB4_Human1.07291493
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.06410970
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06286166
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06100060
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05651760
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04852498
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03161293
83* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02609843
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00225399
85STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00104106
86ESR1_20079471_ChIP-ChIP_T-47D_Human0.98945095
87KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98291895
88BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98186618
89UBF1/2_26484160_Chip-Seq_HMECs_Human0.96662028
90TBX20_22328084_ChIP-Seq_HEART_Mouse0.95605728
91TBX20_22080862_ChIP-Seq_HEART_Mouse0.95605728
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95595152
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95108233
94PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94724511
95EGR1_19032775_ChIP-ChIP_M12_Human0.93354991
96EP300_21415370_ChIP-Seq_HL-1_Mouse0.93197725
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92235102
98NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91266983
99* TP63_23658742_ChIP-Seq_EP156T_Human0.90898899
100GATA2_19941826_ChIP-Seq_K562_Human0.90857701
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90100689
102TP53_18474530_ChIP-ChIP_U2OS_Human0.88460047
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86044171
104TCF4_18268006_ChIP-ChIP_LS174T_Human0.85788902
105PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85493210
106MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82913165
107* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82831938
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82578893
109BRD4_25478319_ChIP-Seq_HGPS_Human0.82487897
110HNF4A_19822575_ChIP-Seq_HepG2_Human0.82014644
111AHR_22903824_ChIP-Seq_MCF-7_Human0.81326560
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81169075
113JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80582923
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80456348
115P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79771647
116* GATA6_25053715_ChIP-Seq_YYC3_Human0.74703536
117MYB_26560356_Chip-Seq_TH2_Human0.73847767
118* PU_27001747_Chip-Seq_BMDM_Mouse0.72893303
119MAF_26560356_Chip-Seq_TH1_Human0.72300711
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.71572809
121ELK3_25401928_ChIP-Seq_HUVEC_Human0.70552993
122RXR_22108803_ChIP-Seq_LS180_Human0.70082014
123BCAT_22108803_ChIP-Seq_LS180_Human0.69534035
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68899990
125MYB_26560356_Chip-Seq_TH1_Human0.68530912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.96202935
2MP0002139_abnormal_hepatobiliary_system4.82088075
3MP0005085_abnormal_gallbladder_physiolo3.96914143
4MP0005365_abnormal_bile_salt3.61876449
5MP0003705_abnormal_hypodermis_morpholog3.42841612
6* MP0008875_abnormal_xenobiotic_pharmacok3.09576658
7MP0003191_abnormal_cellular_cholesterol3.06011303
8MP0002138_abnormal_hepatobiliary_system2.68962513
9* MP0003252_abnormal_bile_duct2.67908742
10MP0009840_abnormal_foam_cell2.45972552
11MP0010329_abnormal_lipoprotein_level2.22349682
12MP0003724_increased_susceptibility_to2.20001419
13MP0010368_abnormal_lymphatic_system2.09560761
14MP0002877_abnormal_melanocyte_morpholog2.06007562
15MP0002254_reproductive_system_inflammat2.04032212
16MP0006054_spinal_hemorrhage1.88581904
17MP0001835_abnormal_antigen_presentation1.87221168
18MP0003091_abnormal_cell_migration1.87194525
19MP0003436_decreased_susceptibility_to1.84522700
20MP0008004_abnormal_stomach_pH1.83879088
21MP0003300_gastrointestinal_ulcer1.82907855
22MP0002998_abnormal_bone_remodeling1.82895927
23MP0000465_gastrointestinal_hemorrhage1.79445757
24MP0001958_emphysema1.79197124
25MP0003806_abnormal_nucleotide_metabolis1.73285434
26MP0010234_abnormal_vibrissa_follicle1.67461631
27* MP0000609_abnormal_liver_physiology1.65735631
28MP0001851_eye_inflammation1.64469413
29MP0001666_abnormal_nutrient_absorption1.63139132
30MP0005058_abnormal_lysosome_morphology1.62816355
31MP0003303_peritoneal_inflammation1.58725421
32* MP0003828_pulmonary_edema1.58062403
33MP0009785_altered_susceptibility_to1.56953525
34MP0002009_preneoplasia1.55029505
35* MP0009764_decreased_sensitivity_to1.53085116
36MP0004019_abnormal_vitamin_homeostasis1.52566850
37* MP0001853_heart_inflammation1.51378915
38MP0005083_abnormal_biliary_tract1.49764786
39MP0000685_abnormal_immune_system1.44424466
40MP0005275_abnormal_skin_tensile1.41984404
41MP0004947_skin_inflammation1.37497497
42MP0002796_impaired_skin_barrier1.35818961
43MP0002060_abnormal_skin_morphology1.34231714
44MP0003045_fibrosis1.32264538
45MP0005023_abnormal_wound_healing1.30136097
46MP0003763_abnormal_thymus_physiology1.27306688
47* MP0002420_abnormal_adaptive_immunity1.25465734
48* MP0001819_abnormal_immune_cell1.25027381
49MP0005332_abnormal_amino_acid1.23940591
50MP0002933_joint_inflammation1.23230364
51MP0001879_abnormal_lymphatic_vessel1.21648506
52MP0003950_abnormal_plasma_membrane1.20022811
53MP0003566_abnormal_cell_adhesion1.19499127
54MP0002118_abnormal_lipid_homeostasis1.18613221
55MP0004272_abnormal_basement_membrane1.18220121
56MP0008438_abnormal_cutaneous_collagen1.18074041
57* MP0003453_abnormal_keratinocyte_physiol1.17274564
58* MP0005025_abnormal_response_to1.17239429
59* MP0001790_abnormal_immune_system1.17059376
60* MP0005387_immune_system_phenotype1.17059376
61* MP0010155_abnormal_intestine_physiology1.16308616
62MP0003172_abnormal_lysosome_physiology1.16044981
63MP0000343_altered_response_to1.15097652
64MP0000858_altered_metastatic_potential1.13679041
65* MP0002419_abnormal_innate_immunity1.11627080
66MP0005409_darkened_coat_color1.11101041
67MP0002166_altered_tumor_susceptibility1.10946598
68MP0003195_calcinosis1.10675762
69MP0000569_abnormal_digit_pigmentation1.09473292
70MP0001533_abnormal_skeleton_physiology1.08904683
71MP0005451_abnormal_body_composition1.08836379
72MP0005390_skeleton_phenotype1.07779164
73MP0005000_abnormal_immune_tolerance1.07090945
74MP0004782_abnormal_surfactant_physiolog1.07065108
75MP0003656_abnormal_erythrocyte_physiolo1.05818744
76MP0001800_abnormal_humoral_immune1.05646137
77* MP0009763_increased_sensitivity_to1.05615836
78MP0002006_tumorigenesis1.05112154
79* MP0005319_abnormal_enzyme/_coenzyme1.03672932
80* MP0005165_increased_susceptibility_to1.03553714
81* MP0010352_gastrointestinal_tract_polyps1.02077133
82MP0004381_abnormal_hair_follicle1.01561475
83* MP0008469_abnormal_protein_level1.00903665
84MP0005397_hematopoietic_system_phenotyp0.98647511
85MP0001545_abnormal_hematopoietic_system0.98647511
86MP0003011_delayed_dark_adaptation0.98597970
87MP0004808_abnormal_hematopoietic_stem0.98271899
88MP0005248_abnormal_Harderian_gland0.98201279
89MP0005408_hypopigmentation0.97868674
90* MP0001216_abnormal_epidermal_layer0.96971928
91* MP0001845_abnormal_inflammatory_respons0.94888529
92MP0001881_abnormal_mammary_gland0.93746089
93MP0000604_amyloidosis0.93457618
94* MP0002405_respiratory_system_inflammati0.92134750
95MP0005464_abnormal_platelet_physiology0.91823236
96MP0005671_abnormal_response_to0.91323834
97* MP0002452_abnormal_antigen_presenting0.90371507
98MP0006082_CNS_inflammation0.90300993
99* MP0002723_abnormal_immune_serum0.89870492
100MP0000383_abnormal_hair_follicle0.89777034
101* MP0000716_abnormal_immune_system0.89190655
102* MP0002148_abnormal_hypersensitivity_rea0.89066514
103MP0009053_abnormal_anal_canal0.88626349
104MP0003279_aneurysm0.87415473
105MP0003795_abnormal_bone_structure0.86661056
106MP0002332_abnormal_exercise_endurance0.86154863
107* MP0000598_abnormal_liver_morphology0.85413372
108MP0002168_other_aberrant_phenotype0.85056569
109MP0001243_abnormal_dermal_layer0.84936071
110MP0003868_abnormal_feces_composition0.84065107
111MP0002896_abnormal_bone_mineralization0.83055232
112MP0009278_abnormal_bone_marrow0.81915691
113MP0009384_cardiac_valve_regurgitation0.81632244
114MP0005076_abnormal_cell_differentiation0.81027991
115MP0009643_abnormal_urine_homeostasis0.80557795
116MP0002398_abnormal_bone_marrow0.79463633
117* MP0000767_abnormal_smooth_muscle0.79049650
118MP0000249_abnormal_blood_vessel0.78012946
119MP0005166_decreased_susceptibility_to0.77255600
120MP0004510_myositis0.76991261
121* MP0000627_abnormal_mammary_gland0.76681333
122* MP0002133_abnormal_respiratory_system0.76435403
123* MP0005388_respiratory_system_phenotype0.76435403
124MP0000013_abnormal_adipose_tissue0.76218373
125MP0003448_altered_tumor_morphology0.75789276
126MP0001542_abnormal_bone_strength0.75491248
127MP0004264_abnormal_extraembryonic_tissu0.74795650
128MP0005595_abnormal_vascular_smooth0.74741295
129MP0002098_abnormal_vibrissa_morphology0.73945126
130MP0005167_abnormal_blood-brain_barrier0.73740010
131* MP0005584_abnormal_enzyme/coenzyme_acti0.73732298
132MP0000579_abnormal_nail_morphology0.73574657
133MP0005164_abnormal_response_to0.73467549
134MP0004883_abnormal_blood_vessel0.72812939
135MP0005501_abnormal_skin_physiology0.72700700
136MP0003075_altered_response_to0.72161507
137MP0009697_abnormal_copulation0.72078066
138MP0001764_abnormal_homeostasis0.72001815
139MP0010678_abnormal_skin_adnexa0.70745347

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.17551527
2Intrahepatic cholestasis (HP:0001406)5.32648403
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.88881327
4Prolonged partial thromboplastin time (HP:0003645)4.88568979
5Xanthomatosis (HP:0000991)4.76727369
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.54107711
7Hypobetalipoproteinemia (HP:0003563)4.24534484
8Complement deficiency (HP:0004431)4.16268474
9Abnormality of the common coagulation pathway (HP:0010990)4.13250482
10Myocardial infarction (HP:0001658)4.10413184
11Joint hemorrhage (HP:0005261)3.99744997
12Epidermoid cyst (HP:0200040)3.74264704
13Hyperlipoproteinemia (HP:0010980)3.60879568
14Esophageal varix (HP:0002040)3.56584182
15Recurrent gram-negative bacterial infections (HP:0005420)3.50592178
16Hypercholesterolemia (HP:0003124)3.50253805
17Abnormality of complement system (HP:0005339)3.45511265
18Hypolipoproteinemia (HP:0010981)3.44179859
19Eczematoid dermatitis (HP:0000976)3.43737775
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.43050252
21Spondylolisthesis (HP:0003302)3.40409673
22Hypoalphalipoproteinemia (HP:0003233)3.29110276
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.14896563
24Peritonitis (HP:0002586)3.08260151
25Aortic dissection (HP:0002647)3.05433186
26Abnormality of liposaccharide metabolism (HP:0010968)3.01858649
27Abnormality of glycosphingolipid metabolism (HP:0004343)3.01858649
28Abnormality of glycolipid metabolism (HP:0010969)3.01858649
29Fat malabsorption (HP:0002630)2.99928995
30Abnormality of the intrinsic pathway (HP:0010989)2.87343151
31Aortic aneurysm (HP:0004942)2.86943273
32Abnormality of sulfur amino acid metabolism (HP:0004339)2.86081638
33Gingival bleeding (HP:0000225)2.82755745
34Spontaneous abortion (HP:0005268)2.78206676
35Premature rupture of membranes (HP:0001788)2.77246394
36Hepatocellular carcinoma (HP:0001402)2.70300520
37Arterial tortuosity (HP:0005116)2.68128364
38Dysostosis multiplex (HP:0000943)2.66419703
39Abnormality of macrophages (HP:0004311)2.65758138
40Conjugated hyperbilirubinemia (HP:0002908)2.65328131
41Hyperammonemia (HP:0001987)2.65022250
42Abnormality of methionine metabolism (HP:0010901)2.63715041
43Systemic lupus erythematosus (HP:0002725)2.58560261
44Vascular tortuosity (HP:0004948)2.52554521
45Subacute progressive viral hepatitis (HP:0006572)2.51414583
46Thrombophlebitis (HP:0004418)2.51029249
47Hypoglycemic coma (HP:0001325)2.49380469
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.48974127
49Abnormality of pyrimidine metabolism (HP:0004353)2.45709329
50Gastrointestinal infarctions (HP:0005244)2.45669746
51Elevated erythrocyte sedimentation rate (HP:0003565)2.44702495
52Mitral stenosis (HP:0001718)2.44656172
53Vertebral compression fractures (HP:0002953)2.41999255
54Recurrent bacterial skin infections (HP:0005406)2.40529394
55Alopecia of scalp (HP:0002293)2.39286190
56Cerebral aneurysm (HP:0004944)2.37602787
57Cardiovascular calcification (HP:0011915)2.36724859
58Vascular calcification (HP:0004934)2.33513945
59Recurrent abscess formation (HP:0002722)2.31872849
60Mucopolysacchariduria (HP:0008155)2.29980136
61Urinary glycosaminoglycan excretion (HP:0003541)2.29980136
62Atrophic scars (HP:0001075)2.28701634
63Pulmonary embolism (HP:0002204)2.26621565
64Dilatation of the ascending aorta (HP:0005111)2.25809497
65Menorrhagia (HP:0000132)2.24031764
66Skin nodule (HP:0200036)2.23674770
67Hemorrhage of the eye (HP:0011885)2.23300633
68Hypochromic microcytic anemia (HP:0004840)2.22735301
69Nephritis (HP:0000123)2.22227998
70Polycythemia (HP:0001901)2.22174925
71Increased mean platelet volume (HP:0011877)2.21722732
72Absent frontal sinuses (HP:0002688)2.21568794
73Vacuolated lymphocytes (HP:0001922)2.20870155
74Pulmonary infiltrates (HP:0002113)2.20312681
75Optic neuritis (HP:0100653)2.19859744
76Retrobulbar optic neuritis (HP:0100654)2.19859744
77Spinal cord lesions (HP:0100561)2.18652441
78Syringomyelia (HP:0003396)2.18652441
79Steatorrhea (HP:0002570)2.17865201
80Abnormality of polysaccharide metabolism (HP:0011012)2.16643127
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16643127
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16643127
83Camptodactyly of toe (HP:0001836)2.13534540
84Joint swelling (HP:0001386)2.12323260
85Periodontitis (HP:0000704)2.11360519
86Glomerulonephritis (HP:0000099)2.10996653
87Chorioretinal atrophy (HP:0000533)2.09687686
88Spontaneous hematomas (HP:0007420)2.08254305
89Interstitial pulmonary disease (HP:0006530)2.07602541
90Tetraparesis (HP:0002273)2.06896126
91Hydroxyprolinuria (HP:0003080)2.05367138
92Abnormality of proline metabolism (HP:0010907)2.05367138
93Abnormal platelet volume (HP:0011876)2.04793116
94Orchitis (HP:0100796)2.04516303
95Gingivitis (HP:0000230)2.02021883
96Cervical subluxation (HP:0003308)2.01924214
97Arterial thrombosis (HP:0004420)2.01783868
98Coarse hair (HP:0002208)2.00246668
99Stomatitis (HP:0010280)1.99867734
100Portal hypertension (HP:0001409)1.99239328
101Osteolytic defects of the hand bones (HP:0009699)1.98225672
102Osteolytic defects of the phalanges of the hand (HP:0009771)1.98225672
103Abnormality of nucleobase metabolism (HP:0010932)1.97042451
104Increased IgE level (HP:0003212)1.96549533
105Increased cerebral lipofuscin (HP:0011813)1.95205570
106Recurrent cutaneous fungal infections (HP:0011370)1.94934645
107Chronic mucocutaneous candidiasis (HP:0002728)1.94934645
108Aneurysm (HP:0002617)1.94427666
109Pigmentary retinal degeneration (HP:0001146)1.93466240
110Wormian bones (HP:0002645)1.93289933
111Recurrent skin infections (HP:0001581)1.93289198
112Vasculitis (HP:0002633)1.92569683
113Autoimmune hemolytic anemia (HP:0001890)1.91458037
114Hematochezia (HP:0002573)1.90755098
115Right ventricular cardiomyopathy (HP:0011663)1.89041123
116Autoimmune thrombocytopenia (HP:0001973)1.88806077
117Ketosis (HP:0001946)1.88322061
118Spastic diplegia (HP:0001264)1.85704716
119Gangrene (HP:0100758)1.85462885
120Pancreatitis (HP:0001733)1.85210306
121Amyloidosis (HP:0011034)1.84430021
122Short nail (HP:0001799)1.83540885
123Persistence of primary teeth (HP:0006335)1.83243581
124Thick nail (HP:0001805)1.83002188
125Colitis (HP:0002583)1.82130777
126Keratoconjunctivitis sicca (HP:0001097)1.81876737
127Recurrent fungal infections (HP:0002841)1.81552263
128Hepatitis (HP:0012115)1.81121115
129Fatigue (HP:0012378)1.80341268
130Abnormality of the hepatic vasculature (HP:0006707)1.79627152
131Abnormality of iron homeostasis (HP:0011031)1.79291749
132Abnormality of T cell number (HP:0011839)1.79230318
133Hyperglycinemia (HP:0002154)1.79205208
134Viral hepatitis (HP:0006562)1.79162621
135Flat acetabular roof (HP:0003180)1.78396697
136Epistaxis (HP:0000421)1.78279921
137Hyperbilirubinemia (HP:0002904)1.77786724
138Protrusio acetabuli (HP:0003179)1.77431980
139Hypertriglyceridemia (HP:0002155)1.76406779
140Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76048547
141Hyperglycinuria (HP:0003108)1.75942020
142Myositis (HP:0100614)1.74910216
143Delayed CNS myelination (HP:0002188)1.74807087
144Recurrent viral infections (HP:0004429)1.74461404
145Cellulitis (HP:0100658)1.74324408
146T lymphocytopenia (HP:0005403)1.73787070
147Abnormality of purine metabolism (HP:0004352)1.72709011
148Loss of speech (HP:0002371)1.72499157
149Mitral valve prolapse (HP:0001634)1.70933033
150Abnormality of the nasal septum (HP:0000419)1.69751105
151Urticaria (HP:0001025)1.68924295
152Follicular hyperkeratosis (HP:0007502)1.68802277
153Abnormal delayed hypersensitivity skin test (HP:0002963)1.68463018
154Chest pain (HP:0100749)1.68332550
155Plantar hyperkeratosis (HP:0007556)1.68253376
156Reduced subcutaneous adipose tissue (HP:0003758)1.68041298
157Hemoptysis (HP:0002105)1.67781122
158Mediastinal lymphadenopathy (HP:0100721)1.67748156
159Milia (HP:0001056)1.67693508
160Neurofibrillary tangles (HP:0002185)1.66758428
161Pustule (HP:0200039)1.65855305
162Distal lower limb amyotrophy (HP:0008944)1.65589975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR43.26199796
2ERN13.09508755
3MAP3K143.09420693
4SIK12.73579907
5EPHA32.68497672
6EPHB12.42907385
7PRPF4B2.39194461
8TGFBR22.30601874
9TXK2.28854768
10MST1R2.28384971
11TYK22.25428737
12LATS12.20696295
13FGFR32.04834370
14JAK32.00864432
15PTK61.98880798
16TBK11.96934063
17JAK11.92616907
18NEK91.86652002
19MAP4K11.83166665
20BLK1.80780781
21TAOK31.78390616
22STK101.69091003
23IKBKB1.56822402
24CHUK1.56080381
25MST41.54899612
26TIE11.53256032
27KIT1.48910375
28FRK1.45054412
29MAP3K31.41084532
30AKT31.40322500
31KDR1.38558582
32JAK21.37783818
33DDR21.36671979
34FER1.31468456
35MAP3K61.24317240
36ERBB41.23427853
37IKBKE1.20700843
38CDK61.19453106
39CDK121.19147053
40CSK1.18123241
41RIPK11.13877061
42ZAP701.13680803
43PBK1.11996295
44BCKDK1.10285320
45MAP2K31.08799200
46STK31.05957465
47TRPM71.05404928
48TGFBR11.03741958
49CDC42BPA1.02784207
50LRRK21.01723341
51TRIB31.01686647
52BMX1.00711486
53MAP3K101.00023575
54FES0.98340996
55IRAK40.94962976
56EPHB20.94847991
57MAP3K130.93144968
58EPHA20.91674979
59TTN0.90059088
60NLK0.88926668
61RIPK40.87733629
62MAP3K70.84603904
63STK240.84209861
64IRAK30.83801183
65PKN20.83364446
66MYLK0.80348757
67ITK0.79711733
68ERBB20.78655217
69FGFR20.77634309
70SGK30.75591025
71INSRR0.75280786
72SCYL20.75093832
73NUAK10.74106566
74FGFR10.74039767
75MATK0.73703272
76SYK0.73185878
77GRK70.73085648
78PAK40.72797660
79MELK0.71544300
80CSF1R0.71393796
81MET0.70749864
82RPS6KA40.69657292
83GSK3A0.68181125
84PTK20.67660532
85ABL10.66308849
86PDPK10.66007238
87MAP3K10.64626269
88WNK10.64613717
89PRKCQ0.63528557
90MAP3K20.63278198
91IGF1R0.63123712
92HCK0.63078443
93LMTK20.62965441
94PDGFRB0.61798741
95PIK3CG0.60565094
96CAMKK20.60037642
97TEC0.59634226
98MAPK110.58794335
99BTK0.58622067
100FLT30.57709408
101GRK60.56131697
102PAK20.55641710
103ABL20.54824178
104HIPK20.53578589
105LCK0.52989479
106RPS6KA20.52952056
107EEF2K0.52826212
108IRAK10.52630114
109GRK10.52627752
110PDK10.51811408
111IRAK20.51192132
112EGFR0.50069878
113RET0.49988409
114BRD40.49833411
115PIM10.49764766
116CAMK1D0.49037110
117LYN0.48878782
118SGK20.48641644
119MAP3K50.48547938
120INSR0.47747213
121MAPK70.47498465
122MAP3K110.47294946
123ICK0.46637855
124MTOR0.46434689
125BMPR20.45455736
126PRKAA20.41629432
127TAOK20.40795925
128MARK30.40293255
129MOS0.39095932
130PIK3CA0.38999433
131PDGFRA0.38575185
132SIK30.38299559
133ERBB30.38286665

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.25187225
2Nitrogen metabolism_Homo sapiens_hsa009103.53901665
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21176783
4Complement and coagulation cascades_Homo sapiens_hsa046103.16707295
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.14445695
6Arginine biosynthesis_Homo sapiens_hsa002202.92912838
7Staphylococcus aureus infection_Homo sapiens_hsa051502.56411635
8Tryptophan metabolism_Homo sapiens_hsa003802.26597179
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16178714
10Other glycan degradation_Homo sapiens_hsa005112.04702906
11Caffeine metabolism_Homo sapiens_hsa002322.03125780
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96895321
13Chemical carcinogenesis_Homo sapiens_hsa052041.93842553
14Fatty acid degradation_Homo sapiens_hsa000711.90441436
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87075209
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80954429
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.72943417
18Retinol metabolism_Homo sapiens_hsa008301.71235101
19PPAR signaling pathway_Homo sapiens_hsa033201.68589323
20Histidine metabolism_Homo sapiens_hsa003401.62031746
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60281384
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55936695
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.55032953
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51884627
25Peroxisome_Homo sapiens_hsa041461.45865810
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41965187
27Type I diabetes mellitus_Homo sapiens_hsa049401.35829429
28Rheumatoid arthritis_Homo sapiens_hsa053231.35769277
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.32815557
30Lysosome_Homo sapiens_hsa041421.32120889
31Phenylalanine metabolism_Homo sapiens_hsa003601.30018691
32Selenocompound metabolism_Homo sapiens_hsa004501.28767978
33beta-Alanine metabolism_Homo sapiens_hsa004101.23114093
34Fatty acid metabolism_Homo sapiens_hsa012121.20444321
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18778485
36Bile secretion_Homo sapiens_hsa049761.18270902
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18168386
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16159332
39Pancreatic cancer_Homo sapiens_hsa052121.15250562
40Chronic myeloid leukemia_Homo sapiens_hsa052201.14936629
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14183446
42ABC transporters_Homo sapiens_hsa020101.11189171
43Platelet activation_Homo sapiens_hsa046111.10774143
44Antigen processing and presentation_Homo sapiens_hsa046121.07965006
45Phagosome_Homo sapiens_hsa041451.07635580
46Tyrosine metabolism_Homo sapiens_hsa003501.06218882
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.05037257
48Hepatitis B_Homo sapiens_hsa051611.03779162
49Graft-versus-host disease_Homo sapiens_hsa053321.03243469
50Renal cell carcinoma_Homo sapiens_hsa052111.02069844
51Leishmaniasis_Homo sapiens_hsa051401.01107679
52Starch and sucrose metabolism_Homo sapiens_hsa005001.00511429
53Dorso-ventral axis formation_Homo sapiens_hsa043200.99314124
54Malaria_Homo sapiens_hsa051440.95695245
55Salmonella infection_Homo sapiens_hsa051320.95109391
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93127524
57Shigellosis_Homo sapiens_hsa051310.92682555
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91596313
59Prolactin signaling pathway_Homo sapiens_hsa049170.91432110
60Herpes simplex infection_Homo sapiens_hsa051680.90294832
61Butanoate metabolism_Homo sapiens_hsa006500.89864948
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89014167
63Bladder cancer_Homo sapiens_hsa052190.86706488
64Chemokine signaling pathway_Homo sapiens_hsa040620.86545678
65Apoptosis_Homo sapiens_hsa042100.86222508
66Non-small cell lung cancer_Homo sapiens_hsa052230.85647263
67Allograft rejection_Homo sapiens_hsa053300.83886123
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.83648290
69Fat digestion and absorption_Homo sapiens_hsa049750.82592281
70Toxoplasmosis_Homo sapiens_hsa051450.82094462
71Propanoate metabolism_Homo sapiens_hsa006400.81985605
72TNF signaling pathway_Homo sapiens_hsa046680.80903206
73Lysine degradation_Homo sapiens_hsa003100.78787910
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77903150
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.77045415
76Sphingolipid metabolism_Homo sapiens_hsa006000.76978287
77VEGF signaling pathway_Homo sapiens_hsa043700.75865123
78Viral myocarditis_Homo sapiens_hsa054160.75488811
79Osteoclast differentiation_Homo sapiens_hsa043800.72710642
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72143317
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71183991
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71100512
83Vitamin digestion and absorption_Homo sapiens_hsa049770.68330017
84Sulfur metabolism_Homo sapiens_hsa009200.68130487
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.66749498
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66698031
87Amoebiasis_Homo sapiens_hsa051460.66485093
88Legionellosis_Homo sapiens_hsa051340.65928263
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.64603588
90Pertussis_Homo sapiens_hsa051330.64560640
91Insulin resistance_Homo sapiens_hsa049310.64310358
92Steroid biosynthesis_Homo sapiens_hsa001000.63758752
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62720286
94Measles_Homo sapiens_hsa051620.62601084
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.61626568
96Prostate cancer_Homo sapiens_hsa052150.61226733
97Asthma_Homo sapiens_hsa053100.60733506
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.60715916
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60677348
100Hematopoietic cell lineage_Homo sapiens_hsa046400.60500296
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.59892640
102MicroRNAs in cancer_Homo sapiens_hsa052060.59619035
103mTOR signaling pathway_Homo sapiens_hsa041500.59464947
104Adherens junction_Homo sapiens_hsa045200.58875583
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58771623
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58272494
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57298058
108FoxO signaling pathway_Homo sapiens_hsa040680.57149431
109Small cell lung cancer_Homo sapiens_hsa052220.56765736
110GnRH signaling pathway_Homo sapiens_hsa049120.56292323
111HIF-1 signaling pathway_Homo sapiens_hsa040660.56161434
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54581018
113ECM-receptor interaction_Homo sapiens_hsa045120.54319180
114Inositol phosphate metabolism_Homo sapiens_hsa005620.54231386
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53196900
116Endometrial cancer_Homo sapiens_hsa052130.52997239
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52790363
118Biosynthesis of amino acids_Homo sapiens_hsa012300.52096085
119Viral carcinogenesis_Homo sapiens_hsa052030.51600481
120Fatty acid biosynthesis_Homo sapiens_hsa000610.51301117
121Thyroid cancer_Homo sapiens_hsa052160.50568494
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.49224828
123Fatty acid elongation_Homo sapiens_hsa000620.49094216
124Systemic lupus erythematosus_Homo sapiens_hsa053220.48955375
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48214235
126Folate biosynthesis_Homo sapiens_hsa007900.47361075
127HTLV-I infection_Homo sapiens_hsa051660.47342098
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.46276244
129ErbB signaling pathway_Homo sapiens_hsa040120.46034203
130Renin-angiotensin system_Homo sapiens_hsa046140.46014446
131Endocytosis_Homo sapiens_hsa041440.44982381
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44620582
133Autoimmune thyroid disease_Homo sapiens_hsa053200.44600342
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44252389
135Circadian rhythm_Homo sapiens_hsa047100.43425354
136Primary immunodeficiency_Homo sapiens_hsa053400.43388995
137Choline metabolism in cancer_Homo sapiens_hsa052310.43317462
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43276510
139Pathways in cancer_Homo sapiens_hsa052000.42397309
140African trypanosomiasis_Homo sapiens_hsa051430.42203906
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41901381
142Arginine and proline metabolism_Homo sapiens_hsa003300.40813728
143Prion diseases_Homo sapiens_hsa050200.40009531
144Tuberculosis_Homo sapiens_hsa051520.39687312
145B cell receptor signaling pathway_Homo sapiens_hsa046620.38706896
146T cell receptor signaling pathway_Homo sapiens_hsa046600.38557617
147Hepatitis C_Homo sapiens_hsa051600.37930003
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37926855
149Influenza A_Homo sapiens_hsa051640.36142322
150Proteoglycans in cancer_Homo sapiens_hsa052050.35005106
151Acute myeloid leukemia_Homo sapiens_hsa052210.34330511
152Carbon metabolism_Homo sapiens_hsa012000.33903531
153Focal adhesion_Homo sapiens_hsa045100.33838836
154Glycerolipid metabolism_Homo sapiens_hsa005610.33625929
155One carbon pool by folate_Homo sapiens_hsa006700.30804913
156Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30011152
157Pyruvate metabolism_Homo sapiens_hsa006200.29057215

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