AHRR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)5.23177925
2regulation of vitamin D biosynthetic process (GO:0060556)4.81943343
3negative regulation of mast cell activation (GO:0033004)4.13978087
4adhesion of symbiont to host cell (GO:0044650)4.07391482
5virion attachment to host cell (GO:0019062)4.07391482
6protein localization to endosome (GO:0036010)4.00746978
7mannose metabolic process (GO:0006013)3.86601917
8positive regulation of chemokine biosynthetic process (GO:0045080)3.83907629
9adhesion of symbiont to host (GO:0044406)3.82270264
10negative regulation of interleukin-12 production (GO:0032695)3.76793762
11pinocytosis (GO:0006907)3.72829928
12regulation of mononuclear cell migration (GO:0071675)3.71714166
13NIK/NF-kappaB signaling (GO:0038061)3.71587696
14regulation of rhodopsin mediated signaling pathway (GO:0022400)3.66946504
15regulation of vitamin metabolic process (GO:0030656)3.64528834
16neutrophil activation involved in immune response (GO:0002283)3.64235609
17rhodopsin mediated signaling pathway (GO:0016056)3.61362469
18regulation of early endosome to late endosome transport (GO:2000641)3.45979386
19interferon-gamma production (GO:0032609)3.42484112
20CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.40797602
21stress fiber assembly (GO:0043149)3.39470083
22hyaluronan catabolic process (GO:0030214)3.36422117
23skin morphogenesis (GO:0043589)3.36068001
24barbed-end actin filament capping (GO:0051016)3.32293611
25positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.27357875
26dendritic cell chemotaxis (GO:0002407)3.26261069
27G-protein coupled receptor internalization (GO:0002031)3.23778203
28regulation of mast cell activation (GO:0033003)3.23514236
29positive regulation of mast cell activation involved in immune response (GO:0033008)3.21549254
30positive regulation of mast cell degranulation (GO:0043306)3.21549254
31positive regulation of extracellular matrix organization (GO:1903055)3.20452435
32lipopolysaccharide-mediated signaling pathway (GO:0031663)3.19988118
33negative regulation of erythrocyte differentiation (GO:0045647)3.19422713
34neutrophil activation (GO:0042119)3.16823582
35regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.15802251
36positive regulation of cellular amide metabolic process (GO:0034250)3.15649324
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.15057366
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.14274050
39photoreceptor cell maintenance (GO:0045494)3.12822112
40positive regulation by symbiont of host defense response (GO:0052509)3.12661105
41modulation by symbiont of host defense response (GO:0052031)3.12661105
42modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.12661105
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.12661105
44positive regulation by organism of defense response of other organism involved in symbiotic interact3.12661105
45modulation by symbiont of host immune response (GO:0052553)3.12661105
46superoxide metabolic process (GO:0006801)3.12579998
47T-helper 1 type immune response (GO:0042088)3.11658741
48regulation of activation of Janus kinase activity (GO:0010533)3.11633724
49DNA integration (GO:0015074)3.08797249
50cell migration involved in heart development (GO:0060973)3.07997840
51dendritic cell migration (GO:0036336)3.06248100
52positive regulation of macrophage cytokine production (GO:0060907)3.05526179
53myeloid dendritic cell differentiation (GO:0043011)3.03976853
54regulation of mast cell degranulation (GO:0043304)3.03610011
55regulation of mast cell activation involved in immune response (GO:0033006)3.01060267
56regulation of cytokine secretion involved in immune response (GO:0002739)3.00734649
57response to peptidoglycan (GO:0032494)2.99658720
58regulation of chemokine biosynthetic process (GO:0045073)2.99252835
59cellular response to arsenic-containing substance (GO:0071243)2.98266321
60negative regulation of monooxygenase activity (GO:0032769)2.97632431
61negative regulation of nitric oxide biosynthetic process (GO:0045019)2.95793309
62response to muramyl dipeptide (GO:0032495)2.93093284
63G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.92451231
64detection of other organism (GO:0098543)2.91927575
65mesenchymal cell differentiation involved in kidney development (GO:0072161)2.90986327
66mesenchymal cell differentiation involved in renal system development (GO:2001012)2.90986327
67negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.90661839
68kinetochore assembly (GO:0051382)2.90582793
69regulation of type I interferon-mediated signaling pathway (GO:0060338)2.89527053
70glycolipid catabolic process (GO:0019377)2.88558384
71positive regulation of mast cell activation (GO:0033005)2.88095160
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.87916601
73oligosaccharide catabolic process (GO:0009313)2.87656062
74regulation of antigen processing and presentation (GO:0002577)2.85831836
75detection of molecule of bacterial origin (GO:0032490)2.85507808
76regulation of T-helper 1 cell differentiation (GO:0045625)2.84764222
77centriole assembly (GO:0098534)2.80890533
78omega-hydroxylase P450 pathway (GO:0097267)2.80290759
79protein heterotrimerization (GO:0070208)2.79287571
80granulocyte activation (GO:0036230)2.79020420
81energy homeostasis (GO:0097009)2.78312936
82decidualization (GO:0046697)2.78082989
83cellular response to exogenous dsRNA (GO:0071360)2.77519406
84cell adhesion mediated by integrin (GO:0033627)2.77470112
85positive regulation of antigen processing and presentation (GO:0002579)2.77425203
86regulation of membrane protein ectodomain proteolysis (GO:0051043)2.77216226
87cellular response to thyroid hormone stimulus (GO:0097067)2.76316600
88retinal cone cell development (GO:0046549)2.75735331
89positive regulation of interleukin-1 beta secretion (GO:0050718)2.75234498
90histamine secretion (GO:0001821)2.73798370
91regulation of apoptotic process involved in morphogenesis (GO:1902337)2.73146845
92COPI coating of Golgi vesicle (GO:0048205)2.71122398
93Golgi transport vesicle coating (GO:0048200)2.71122398
94endodermal cell differentiation (GO:0035987)2.69420733
95regulation of nuclear cell cycle DNA replication (GO:0033262)2.68956841
96regulation of integrin activation (GO:0033623)2.68848423
97amino sugar catabolic process (GO:0046348)2.68535417
98protein K6-linked ubiquitination (GO:0085020)2.68069343
99bone remodeling (GO:0046849)2.68057024
100response to laminar fluid shear stress (GO:0034616)2.67954665
101positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.66481484
102macrophage activation involved in immune response (GO:0002281)2.65804816
103negative regulation of DNA-dependent DNA replication (GO:2000104)2.65020649
104response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.64781883
105response to host immune response (GO:0052572)2.64781883
106collagen fibril organization (GO:0030199)2.64433658
107dendritic cell differentiation (GO:0097028)2.64067011
108replicative senescence (GO:0090399)2.62684109
109positive regulation of endothelial cell apoptotic process (GO:2000353)2.61746183
110regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.61608588
111substrate-dependent cell migration (GO:0006929)2.60282077
112regulation of macrophage cytokine production (GO:0010935)2.58179475
113negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.58018170
114regulation of podosome assembly (GO:0071801)2.57053085
115activation of MAPKKK activity (GO:0000185)2.56777337
116apoptotic cell clearance (GO:0043277)2.56706995
117regulation of macrophage chemotaxis (GO:0010758)2.56243448
118membrane lipid catabolic process (GO:0046466)2.55750528
119production of molecular mediator involved in inflammatory response (GO:0002532)2.55672946
120immunoglobulin mediated immune response (GO:0016064)2.55560450
121kinetochore organization (GO:0051383)2.54974982
122eye photoreceptor cell development (GO:0042462)2.53514807
123negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52994301
124positive regulation of T cell migration (GO:2000406)2.52403112
125positive regulation of heat generation (GO:0031652)2.52124625
126tRNA methylation (GO:0030488)2.50033210
127response to thyroid hormone (GO:0097066)2.49377479
128positive regulation of interleukin-1 secretion (GO:0050716)2.48345623
129T cell lineage commitment (GO:0002360)2.48295465
130venous blood vessel morphogenesis (GO:0048845)2.47755296
131purinergic nucleotide receptor signaling pathway (GO:0035590)2.47704671
132photoreceptor cell development (GO:0042461)2.46658992
133response to protozoan (GO:0001562)2.46579039
134regulation of interleukin-1 beta secretion (GO:0050706)2.46370085
135modulation by symbiont of host cellular process (GO:0044068)2.45986686
136cortical actin cytoskeleton organization (GO:0030866)2.45967015
137regulation of interferon-beta biosynthetic process (GO:0045357)2.45448634
138germinal center formation (GO:0002467)2.45151932
139regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.44916093
140glycosphingolipid catabolic process (GO:0046479)2.44542319
141mature B cell differentiation involved in immune response (GO:0002313)2.44423079
142ganglion development (GO:0061548)2.44337275
143phagocytosis, engulfment (GO:0006911)2.43894830
144respiratory burst (GO:0045730)2.43549206
145centriole replication (GO:0007099)2.43102827
146regulation of interleukin-2 biosynthetic process (GO:0045076)2.43048019
147positive regulation of gamma-delta T cell activation (GO:0046645)2.41874993
148positive regulation of natural killer cell activation (GO:0032816)2.40572732
149detection of light stimulus involved in visual perception (GO:0050908)2.40416664
150detection of light stimulus involved in sensory perception (GO:0050962)2.40416664
151response to arsenic-containing substance (GO:0046685)2.40381024
152positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.40335690
153regulation of monocyte chemotaxis (GO:0090025)2.39939491
154regulation of interferon-gamma biosynthetic process (GO:0045072)2.39822915
155hydrogen peroxide biosynthetic process (GO:0050665)2.38407424
156response to type I interferon (GO:0034340)2.38065984
157myeloid dendritic cell activation (GO:0001773)2.35856905
158cellular response to type I interferon (GO:0071357)2.35623047
159type I interferon signaling pathway (GO:0060337)2.35623047
160collagen metabolic process (GO:0032963)2.35425490
161polyketide metabolic process (GO:0030638)2.35361189
162doxorubicin metabolic process (GO:0044598)2.35361189
163daunorubicin metabolic process (GO:0044597)2.35361189
164tooth mineralization (GO:0034505)2.35191276
165positive regulation of natural killer cell differentiation (GO:0032825)2.34612669
166regulation of heat generation (GO:0031650)2.33624525
167positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.33267271
168natural killer cell activation involved in immune response (GO:0002323)2.33247114
169microtubule depolymerization (GO:0007019)2.30487688
170protein-chromophore linkage (GO:0018298)2.30345679
171reactive oxygen species biosynthetic process (GO:1903409)2.29473889
172preassembly of GPI anchor in ER membrane (GO:0016254)2.28968780
173regulation of interleukin-6 biosynthetic process (GO:0045408)2.28465831
174platelet dense granule organization (GO:0060155)2.28394436
175detection of bacterium (GO:0016045)2.28389421
176positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.27992866
177regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.27644858
178regulation of neutrophil chemotaxis (GO:0090022)2.27212254
179regulation of neutrophil migration (GO:1902622)2.27212254
180regulation of T cell migration (GO:2000404)2.25975937
181DNA strand renaturation (GO:0000733)2.25486149
182microglial cell activation (GO:0001774)2.24818616
183positive regulation of T cell chemotaxis (GO:0010820)2.24280177
184regulation of T cell chemotaxis (GO:0010819)2.24280177
185ceramide catabolic process (GO:0046514)2.23562002
186regulation of fever generation (GO:0031620)2.23361899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.33520005
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.59467392
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.53902587
4VDR_21846776_ChIP-Seq_THP-1_Human3.37846929
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.25186644
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.18723308
7MYC_22102868_ChIP-Seq_BL_Human3.04074313
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.91253981
9GBX2_23144817_ChIP-Seq_PC3_Human2.81839858
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.80108562
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.73249812
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72182519
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69034572
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.65523316
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.63833199
16* ELK3_25401928_ChIP-Seq_HUVEC_Human2.56053061
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51426134
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.50239582
19VDR_24763502_ChIP-Seq_THP-1_Human2.49858353
20SUZ12_27294783_Chip-Seq_NPCs_Mouse2.48020468
21PCGF2_27294783_Chip-Seq_NPCs_Mouse2.45022811
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.39441599
23NFE2_27457419_Chip-Seq_LIVER_Mouse2.39156132
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.30663937
25LXR_22292898_ChIP-Seq_THP-1_Human2.29365201
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.27612666
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25099749
28* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.10497190
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.04482056
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03126203
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.02512544
32SMAD_19615063_ChIP-ChIP_OVARY_Human2.01219048
33EZH2_27294783_Chip-Seq_NPCs_Mouse2.00985529
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97448694
35STAT3_18555785_Chip-Seq_ESCs_Mouse1.94003469
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91837697
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90135057
38SUZ12_18555785_Chip-Seq_ESCs_Mouse1.89027558
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87866483
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87541205
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87354747
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.86135928
43E2F1_18555785_Chip-Seq_ESCs_Mouse1.85219932
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.84614126
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82072504
46E2F7_22180533_ChIP-Seq_HELA_Human1.80107220
47NMYC_18555785_Chip-Seq_ESCs_Mouse1.79322956
48P53_22387025_ChIP-Seq_ESCs_Mouse1.78595207
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.78583704
50MAF_26560356_Chip-Seq_TH1_Human1.77031804
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.76073150
52EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.75317191
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.75290537
54TFEB_21752829_ChIP-Seq_HELA_Human1.74121426
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73424210
56KDM2B_26808549_Chip-Seq_DND41_Human1.72320209
57P300_18555785_Chip-Seq_ESCs_Mouse1.69778872
58CMYC_18555785_Chip-Seq_ESCs_Mouse1.69565014
59TCF7_22412390_ChIP-Seq_EML_Mouse1.69561522
60RUNX1_27457419_Chip-Seq_LIVER_Mouse1.66845409
61ZFX_18555785_Chip-Seq_ESCs_Mouse1.64985824
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64981942
63OCT4_18555785_Chip-Seq_ESCs_Mouse1.63166910
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61363018
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60578594
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.60532400
67KLF4_18555785_Chip-Seq_ESCs_Mouse1.58612517
68SOX2_18555785_Chip-Seq_ESCs_Mouse1.58276829
69ZNF263_19887448_ChIP-Seq_K562_Human1.57767649
70PU1_27457419_Chip-Seq_LIVER_Mouse1.57052965
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55717990
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54064446
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53453542
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.53006132
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52917618
76IGF1R_20145208_ChIP-Seq_DFB_Human1.52589453
77ESRRB_18555785_Chip-Seq_ESCs_Mouse1.52044331
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51845518
79SMAD1_18555785_Chip-Seq_ESCs_Mouse1.50850944
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50648296
81CTCF_18555785_Chip-Seq_ESCs_Mouse1.50539842
82TP53_22127205_ChIP-Seq_IMR90_Human1.48455402
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.46267090
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46004851
85RACK7_27058665_Chip-Seq_MCF-7_Human1.45806044
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45346298
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43333638
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42775092
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.42679905
90CLOCK_20551151_ChIP-Seq_293T_Human1.41785261
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41182827
92P300_19829295_ChIP-Seq_ESCs_Human1.40759208
93MAF_26560356_Chip-Seq_TH2_Human1.40661549
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40493341
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36725630
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36132497
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35622036
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.35600768
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35034123
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34887850
101OCT4_21477851_ChIP-Seq_ESCs_Mouse1.34807101
102SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.34056264
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.34042790
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33591067
105UTX_26944678_Chip-Seq_JUKART_Human1.32452117
106EWS_26573619_Chip-Seq_HEK293_Human1.28850611
107SPI1_23127762_ChIP-Seq_K562_Human1.27980894
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27605670
109ER_23166858_ChIP-Seq_MCF-7_Human1.27261296
110VDR_24787735_ChIP-Seq_THP-1_Human1.27029040
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26356522
112SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25761066
113VDR_22108803_ChIP-Seq_LS180_Human1.25654687
114BRD4_25478319_ChIP-Seq_HGPS_Human1.24867838
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24744260
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23502192
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.23115626
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22316275
119TRIM28_21343339_ChIP-Seq_HEK293_Human1.21635283
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19568728
121SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19426685
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19358299
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18635712
124KDM2B_26808549_Chip-Seq_JURKAT_Human1.18290695
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17202902
126PU_27001747_Chip-Seq_BMDM_Mouse1.16294598
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15906765
128FOXM1_23109430_ChIP-Seq_U2OS_Human1.15554188
129KDM2B_26808549_Chip-Seq_K562_Human1.15183371
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13747125
131SCL_19346495_ChIP-Seq_HPC-7_Human1.13411174
132PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13310531
133SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12988508
134LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12901471
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11683611
136TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10976109
137EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10479755
138NCOR1_26117541_ChIP-Seq_K562_Human1.10340476
139CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09896379
140SALL1_21062744_ChIP-ChIP_HESCs_Human1.09669230
141GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09208224
142RNF2_27304074_Chip-Seq_NSC_Mouse1.08995716
143MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08727245
144CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08412924
145FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07446948
146ATF3_27146783_Chip-Seq_COLON_Human1.05832211
147FUS_26573619_Chip-Seq_HEK293_Human1.05023402
148MYB_26560356_Chip-Seq_TH1_Human1.02897894
149KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02802877
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02039974
151WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01483508
152FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01404852
153VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00369164
154CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99939669
155TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99543491
156CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97238854
157ESR2_21235772_ChIP-Seq_MCF-7_Human0.96935262
158TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96813220
159ELF1_20517297_ChIP-Seq_JURKAT_Human0.96645732
160CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96072099
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94281421
162TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94281421
163IRF1_19129219_ChIP-ChIP_H3396_Human0.94134635
164TP53_18474530_ChIP-ChIP_U2OS_Human0.94084242
165NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93499388
166STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93494355
167SMAD4_21799915_ChIP-Seq_A2780_Human0.93177442
168JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93041311
169NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92949738
170RUNX_20019798_ChIP-Seq_JUKART_Human0.92357561
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.87504280
172ELK1_19687146_ChIP-ChIP_HELA_Human0.87457475
173SRF_21415370_ChIP-Seq_HL-1_Mouse0.86920954
174STAT1_17558387_ChIP-Seq_HELA_Human0.86236419
175* TCF4_23295773_ChIP-Seq_U87_Human0.84008535
176TAF15_26573619_Chip-Seq_HEK293_Human0.83131611
177POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82838618
178GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82684300
179RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81915852
180E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.81794831
181HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81477048
182SPI1_23547873_ChIP-Seq_NB4_Human0.81205125

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.88532342
2MP0005058_abnormal_lysosome_morphology3.76669969
3MP0003705_abnormal_hypodermis_morpholog3.70323169
4MP0001835_abnormal_antigen_presentation3.33571865
5MP0002277_abnormal_respiratory_mucosa3.00751847
6MP0003303_peritoneal_inflammation2.98329901
7MP0001188_hyperpigmentation2.94323061
8MP0000566_synostosis2.79238133
9MP0003279_aneurysm2.78773832
10MP0002148_abnormal_hypersensitivity_rea2.72507140
11MP0002877_abnormal_melanocyte_morpholog2.58029232
12MP0003300_gastrointestinal_ulcer2.56248891
13MP0002132_abnormal_respiratory_system2.50377011
14MP0003136_yellow_coat_color2.45234087
15MP0003172_abnormal_lysosome_physiology2.45214670
16MP0005671_abnormal_response_to2.44484774
17MP0005171_absent_coat_pigmentation2.43555985
18MP0006292_abnormal_olfactory_placode2.43323200
19MP0009840_abnormal_foam_cell2.37725849
20MP0000015_abnormal_ear_pigmentation2.37647322
21MP0003724_increased_susceptibility_to2.37579491
22MP0001958_emphysema2.31829792
23MP0001542_abnormal_bone_strength2.30258155
24MP0009785_altered_susceptibility_to2.30130866
25MP0005409_darkened_coat_color2.26515425
26MP0005551_abnormal_eye_electrophysiolog2.23668717
27MP0003091_abnormal_cell_migration2.22367318
28MP0008058_abnormal_DNA_repair2.08498909
29MP0002419_abnormal_innate_immunity2.04524942
30MP0006054_spinal_hemorrhage1.99652652
31MP0005000_abnormal_immune_tolerance1.95522105
32MP0005387_immune_system_phenotype1.94149679
33MP0001790_abnormal_immune_system1.94149679
34MP0005503_abnormal_tendon_morphology1.93980491
35MP0003011_delayed_dark_adaptation1.93506165
36MP0005623_abnormal_meninges_morphology1.93234737
37MP0003787_abnormal_imprinting1.92168464
38MP0008057_abnormal_DNA_replication1.89050953
39MP0005174_abnormal_tail_pigmentation1.83197611
40MP0002638_abnormal_pupillary_reflex1.81914444
41MP0009697_abnormal_copulation1.73980020
42MP0002452_abnormal_antigen_presenting1.73529043
43MP0001986_abnormal_taste_sensitivity1.73016876
44MP0003436_decreased_susceptibility_to1.70335839
45MP0006082_CNS_inflammation1.69360624
46MP0005025_abnormal_response_to1.68120610
47MP0002095_abnormal_skin_pigmentation1.68098337
48MP0001800_abnormal_humoral_immune1.68081647
49MP0004782_abnormal_surfactant_physiolog1.65539234
50MP0002163_abnormal_gland_morphology1.64338251
51MP0005310_abnormal_salivary_gland1.63534970
52MP0002723_abnormal_immune_serum1.63296278
53MP0005253_abnormal_eye_physiology1.59761070
54MP0005451_abnormal_body_composition1.59392504
55MP0001346_abnormal_lacrimal_gland1.57663407
56MP0001348_abnormal_lacrimal_gland1.54519428
57MP0002102_abnormal_ear_morphology1.53418277
58MP0003566_abnormal_cell_adhesion1.53196794
59MP0001819_abnormal_immune_cell1.52296514
60MP0002420_abnormal_adaptive_immunity1.52028373
61MP0008260_abnormal_autophagy1.51529599
62MP0002396_abnormal_hematopoietic_system1.48830425
63MP0005075_abnormal_melanosome_morpholog1.48392073
64MP0005076_abnormal_cell_differentiation1.47183203
65MP0000372_irregular_coat_pigmentation1.46367649
66MP0000767_abnormal_smooth_muscle1.46297366
67MP0005023_abnormal_wound_healing1.38272919
68MP0001849_ear_inflammation1.35620900
69MP0010386_abnormal_urinary_bladder1.33698499
70MP0000604_amyloidosis1.33295700
71MP0005275_abnormal_skin_tensile1.33081276
72MP0004947_skin_inflammation1.32653917
73MP0009278_abnormal_bone_marrow1.29769549
74MP0003950_abnormal_plasma_membrane1.26873529
75MP0004381_abnormal_hair_follicle1.26089643
76MP0003453_abnormal_keratinocyte_physiol1.26078135
77MP0004272_abnormal_basement_membrane1.25994490
78MP0009764_decreased_sensitivity_to1.25757944
79MP0005248_abnormal_Harderian_gland1.24417515
80MP0009384_cardiac_valve_regurgitation1.24155737
81MP0004742_abnormal_vestibular_system1.23750859
82MP0005379_endocrine/exocrine_gland_phen1.22665863
83MP0001243_abnormal_dermal_layer1.21770608
84MP0004808_abnormal_hematopoietic_stem1.21560787
85MP0002405_respiratory_system_inflammati1.19686079
86MP0005645_abnormal_hypothalamus_physiol1.18719065
87MP0010352_gastrointestinal_tract_polyps1.18510362
88MP0001324_abnormal_eye_pigmentation1.18200369
89MP0004233_abnormal_muscle_weight1.17128019
90MP0000490_abnormal_crypts_of1.16761612
91MP0000371_diluted_coat_color1.14331984
92MP0003941_abnormal_skin_development1.13534479
93MP0001186_pigmentation_phenotype1.11974626
94MP0005257_abnormal_intraocular_pressure1.10668090
95MP0005508_abnormal_skeleton_morphology1.09352396
96MP0010307_abnormal_tumor_latency1.09108997
97MP0003075_altered_response_to1.08242310
98MP0000685_abnormal_immune_system1.07753885
99MP0000716_abnormal_immune_system1.04571489
100MP0003763_abnormal_thymus_physiology1.04450445
101MP0002998_abnormal_bone_remodeling1.03427565
102MP0002254_reproductive_system_inflammat1.03402391
103MP0000681_abnormal_thyroid_gland1.02971327
104MP0003448_altered_tumor_morphology1.02732034
105MP0002876_abnormal_thyroid_physiology1.00951571
106MP0002896_abnormal_bone_mineralization1.00814285
107MP0000733_abnormal_muscle_development0.99530859
108MP0002075_abnormal_coat/hair_pigmentati0.99431319
109MP0010094_abnormal_chromosome_stability0.98430291
110MP0003795_abnormal_bone_structure0.97763975
111MP0002295_abnormal_pulmonary_circulatio0.97462662
112MP0008469_abnormal_protein_level0.96917656
113MP0009333_abnormal_splenocyte_physiolog0.96842253
114MP0000569_abnormal_digit_pigmentation0.96210342
115MP0002398_abnormal_bone_marrow0.95683346
116MP0002060_abnormal_skin_morphology0.95519223
117MP0003191_abnormal_cellular_cholesterol0.95232419
118MP0004510_myositis0.92782818
119MP0002938_white_spotting0.92156670
120MP0002009_preneoplasia0.91533459
121MP0005397_hematopoietic_system_phenotyp0.91507559
122MP0001545_abnormal_hematopoietic_system0.91507559
123MP0002139_abnormal_hepatobiliary_system0.90879083
124MP0005164_abnormal_response_to0.87977735
125MP0010155_abnormal_intestine_physiology0.87041490
126MP0001502_abnormal_circadian_rhythm0.86751869
127MP0002006_tumorigenesis0.84348364
128MP0005595_abnormal_vascular_smooth0.84100825
129MP0005646_abnormal_pituitary_gland0.84035251
130MP0005464_abnormal_platelet_physiology0.84000375
131MP0001533_abnormal_skeleton_physiology0.82911505
132MP0001853_heart_inflammation0.82355547
133MP0005195_abnormal_posterior_eye0.82272538
134MP0001764_abnormal_homeostasis0.81279097
135MP0000858_altered_metastatic_potential0.79336851
136MP0000343_altered_response_to0.79304955
137MP0001845_abnormal_inflammatory_respons0.79184449
138MP0003828_pulmonary_edema0.79046049
139MP0002933_joint_inflammation0.78238029
140MP0005621_abnormal_cell_physiology0.77852597
141MP0002429_abnormal_blood_cell0.77207326
142MP0005390_skeleton_phenotype0.74783140
143MP0001119_abnormal_female_reproductive0.74777709
144MP0005197_abnormal_uvea_morphology0.74554353
145MP0005391_vision/eye_phenotype0.73987695
146MP0000689_abnormal_spleen_morphology0.72877152
147MP0000026_abnormal_inner_ear0.72567556
148MP0000003_abnormal_adipose_tissue0.72157925
149MP0002113_abnormal_skeleton_development0.71424903
150MP0000383_abnormal_hair_follicle0.70403087
151MP0000613_abnormal_salivary_gland0.70215106
152MP0001915_intracranial_hemorrhage0.69695436
153MP0002722_abnormal_immune_system0.68503777
154MP0008007_abnormal_cellular_replicative0.66636155
155MP0003195_calcinosis0.65802461
156MP0002177_abnormal_outer_ear0.64364363

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.51476928
2Abnormality of liposaccharide metabolism (HP:0010968)4.95334605
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.95334605
4Abnormality of glycolipid metabolism (HP:0010969)4.95334605
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.88402802
6Protrusio acetabuli (HP:0003179)4.86791293
7Chromsome breakage (HP:0040012)4.46352778
8Congenital stationary night blindness (HP:0007642)4.42594392
9Dysostosis multiplex (HP:0000943)3.87045980
10Retrobulbar optic neuritis (HP:0100654)3.82429813
11Optic neuritis (HP:0100653)3.82429813
12Vacuolated lymphocytes (HP:0001922)3.73958217
13Bony spicule pigmentary retinopathy (HP:0007737)3.71206865
14Spondylolisthesis (HP:0003302)3.57343965
15Vertebral compression fractures (HP:0002953)3.53805535
16Ankle contracture (HP:0006466)3.49505755
17Recurrent abscess formation (HP:0002722)3.48376901
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.34616900
19Abnormal rod and cone electroretinograms (HP:0008323)3.32076404
20Orchitis (HP:0100796)3.24949781
21Attenuation of retinal blood vessels (HP:0007843)3.22590763
22Prostate neoplasm (HP:0100787)3.22274428
23Myositis (HP:0100614)3.04998271
24Increased cerebral lipofuscin (HP:0011813)3.03924463
25Urinary glycosaminoglycan excretion (HP:0003541)3.03170225
26Mucopolysacchariduria (HP:0008155)3.03170225
27Abnormality of mucopolysaccharide metabolism (HP:0011020)3.03105678
28Abnormality of polysaccharide metabolism (HP:0011012)3.03105678
29Abnormality of glycosaminoglycan metabolism (HP:0004371)3.03105678
30Duplicated collecting system (HP:0000081)2.99503258
31Aortic aneurysm (HP:0004942)2.98128964
32Abnormality of the renal collecting system (HP:0004742)2.93678249
33Dyschromatopsia (HP:0007641)2.91343194
34Loss of speech (HP:0002371)2.91214368
35Stomach cancer (HP:0012126)2.87888244
36Decreased central vision (HP:0007663)2.84871074
37Bladder diverticulum (HP:0000015)2.82747419
38Genu recurvatum (HP:0002816)2.80454156
39Recurrent bacterial skin infections (HP:0005406)2.77083478
40Hyperacusis (HP:0010780)2.76374742
41Aortic dissection (HP:0002647)2.71109226
42Eczematoid dermatitis (HP:0000976)2.70714793
43Cervical subluxation (HP:0003308)2.68115612
44Achilles tendon contracture (HP:0001771)2.67559098
45Slender build (HP:0001533)2.63290870
46Increased corneal curvature (HP:0100692)2.60460147
47Keratoconus (HP:0000563)2.60460147
48Congenital sensorineural hearing impairment (HP:0008527)2.59997418
49Nuclear cataract (HP:0100018)2.59388752
50White forelock (HP:0002211)2.56168435
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.54143478
52Wormian bones (HP:0002645)2.52852768
53Dilatation of the ascending aorta (HP:0005111)2.52279600
54Follicular hyperkeratosis (HP:0007502)2.52001599
55Vascular tortuosity (HP:0004948)2.51849718
56Spinal rigidity (HP:0003306)2.51349430
57Elbow flexion contracture (HP:0002987)2.50285804
58Recurrent pneumonia (HP:0006532)2.50215902
59Abnormality of incisor morphology (HP:0011063)2.49739776
60Renal cortical cysts (HP:0000803)2.49209726
61Chorioretinal atrophy (HP:0000533)2.48552652
62Emphysema (HP:0002097)2.48321767
63Abnormality of the preputium (HP:0100587)2.47415834
64Blue sclerae (HP:0000592)2.46984963
65Pigmentary retinal degeneration (HP:0001146)2.46267060
66Chronic obstructive pulmonary disease (HP:0006510)2.41543288
67Obstructive lung disease (HP:0006536)2.41543288
68Pendular nystagmus (HP:0012043)2.40669074
69Aplasia/Hypoplasia of the fovea (HP:0008060)2.40490903
70Hypoplasia of the fovea (HP:0007750)2.40490903
71Thin bony cortex (HP:0002753)2.39856470
72Soft skin (HP:0000977)2.38143060
73Abnormality of dentin (HP:0010299)2.38013933
74Patchy hypopigmentation of hair (HP:0011365)2.37653194
75Clubbing of toes (HP:0100760)2.37647146
76Septo-optic dysplasia (HP:0100842)2.37076417
77Type 1 muscle fiber predominance (HP:0003803)2.36057945
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.33948328
79Natal tooth (HP:0000695)2.33163953
80Encephalitis (HP:0002383)2.33103009
81Abnormality of the vasculature of the conjunctiva (HP:0008054)2.31393094
82Aplasia cutis congenita (HP:0001057)2.30552366
83Fragile skin (HP:0001030)2.30435754
84Gastrointestinal stroma tumor (HP:0100723)2.28689540
85Osteolytic defects of the phalanges of the hand (HP:0009771)2.27944283
86Osteolytic defects of the hand bones (HP:0009699)2.27944283
87Myocardial infarction (HP:0001658)2.26467349
88Upper motor neuron abnormality (HP:0002127)2.25503828
89Abnormality of DNA repair (HP:0003254)2.24729048
90Abnormality of the Achilles tendon (HP:0005109)2.24564887
91Photophobia (HP:0000613)2.23957101
92Gingivitis (HP:0000230)2.23861383
93Recurrent cutaneous fungal infections (HP:0011370)2.23324236
94Chronic mucocutaneous candidiasis (HP:0002728)2.23324236
95Meckel diverticulum (HP:0002245)2.22699977
96Ulnar bowing (HP:0003031)2.22264945
97Mitral regurgitation (HP:0001653)2.21762526
98Joint stiffness (HP:0001387)2.21460799
99Tubulointerstitial nephritis (HP:0001970)2.21267030
100Atrophic scars (HP:0001075)2.20662495
101Ectopic kidney (HP:0000086)2.20585327
102Abnormality of chromosome stability (HP:0003220)2.17657432
103Aortic regurgitation (HP:0001659)2.15782508
104Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.14981595
105Premature loss of primary teeth (HP:0006323)2.13338803
106Recurrent fungal infections (HP:0002841)2.12340502
107Bowel diverticulosis (HP:0005222)2.11767632
108Arterial tortuosity (HP:0005116)2.11493759
109Abnormality of the prostate (HP:0008775)2.10992750
110Biconcave vertebral bodies (HP:0004586)2.10660452
111Osteomalacia (HP:0002749)2.10107051
112Keratoconjunctivitis sicca (HP:0001097)2.08941998
113Abnormality of the ileum (HP:0001549)2.06988363
114Abnormality of macrophages (HP:0004311)2.06049950
115Cerebral aneurysm (HP:0004944)2.05919137
116Aneurysm (HP:0002617)2.05460038
117Recurrent lower respiratory tract infections (HP:0002783)2.04980581
118Mediastinal lymphadenopathy (HP:0100721)2.03584121
119Disinhibition (HP:0000734)2.02123885
120Long toe (HP:0010511)2.01475245
121Increased IgM level (HP:0003496)2.01038270
122Duplication of thumb phalanx (HP:0009942)1.99747056
123Entropion (HP:0000621)1.99490049
124Generalized amyotrophy (HP:0003700)1.98620100
125Abnormality of the carotid arteries (HP:0005344)1.98441762
126Conical tooth (HP:0000698)1.98004832
127Severe visual impairment (HP:0001141)1.97232600
128Keratoconjunctivitis (HP:0001096)1.95599174
129Renal duplication (HP:0000075)1.95379305
130Thoracic kyphosis (HP:0002942)1.93638473
131Dynein arm defect of respiratory motile cilia (HP:0012255)1.93069573
132Absent/shortened dynein arms (HP:0200106)1.93069573
133Pancreatic cysts (HP:0001737)1.92845238
134Abnormality of the thoracic spine (HP:0100711)1.92498519
135Recurrent skin infections (HP:0001581)1.90902932
136Meningitis (HP:0001287)1.90851045
137Apathy (HP:0000741)1.89750681
138Increased connective tissue (HP:0009025)1.88553818
139Thoracolumbar scoliosis (HP:0002944)1.88363823
140Sparse lateral eyebrow (HP:0005338)1.88290162
141True hermaphroditism (HP:0010459)1.87446556
142Alveolar cell carcinoma (HP:0006519)1.86601094
143Acrocyanosis (HP:0001063)1.86186613
144Persistence of primary teeth (HP:0006335)1.86134496
145Camptodactyly of toe (HP:0001836)1.85843801
146Vasculitis (HP:0002633)1.85746147
147Cheilitis (HP:0100825)1.85014362
148Abnormal delayed hypersensitivity skin test (HP:0002963)1.84765194
149Stomatitis (HP:0010280)1.84570931
150Ovoid vertebral bodies (HP:0003300)1.83891498
151Diminished motivation (HP:0000745)1.83759649
152Prolonged neonatal jaundice (HP:0006579)1.83518040
153Peritonitis (HP:0002586)1.83491322
154Axonal loss (HP:0003447)1.83157711
155Mitral valve prolapse (HP:0001634)1.81876463
156Chronic hepatic failure (HP:0100626)1.81777143
157Recurrent viral infections (HP:0004429)1.81422776
158Upper limb amyotrophy (HP:0009129)1.81354586
159Distal upper limb amyotrophy (HP:0007149)1.81354586
160Anhidrosis (HP:0000970)1.81156365
161Optic nerve hypoplasia (HP:0000609)1.80600600
162Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.80582758
163Joint laxity (HP:0001388)1.80219478
164Asymmetric septal hypertrophy (HP:0001670)1.80132693
165Cellulitis (HP:0100658)1.78637437
166Systemic lupus erythematosus (HP:0002725)1.77113252
167Spontaneous hematomas (HP:0007420)1.76493329
168Periodontitis (HP:0000704)1.75722321
169Abolished electroretinogram (ERG) (HP:0000550)1.75532443
170Keratitis (HP:0000491)1.75506546
171Increased variability in muscle fiber diameter (HP:0003557)1.75344019
172Flat cornea (HP:0007720)1.75026298
173Nonimmune hydrops fetalis (HP:0001790)1.74820550
174Bone marrow hypocellularity (HP:0005528)1.73750189
175Disproportionate tall stature (HP:0001519)1.73695522
176Elevated erythrocyte sedimentation rate (HP:0003565)1.73521293
177Broad metatarsal (HP:0001783)1.73472790
178Glomerulopathy (HP:0100820)1.73163082
179Pancreatic fibrosis (HP:0100732)1.72792669
180Femoral bowing (HP:0002980)1.71704417
181Abnormality of the fovea (HP:0000493)1.71442087
182Cone-rod dystrophy (HP:0000548)1.70968153
183Neonatal short-limb short stature (HP:0008921)1.70739026
184Abnormality of the acetabulum (HP:0003170)1.70306699
185Prolonged bleeding time (HP:0003010)1.69689585
186Panhypogammaglobulinemia (HP:0003139)1.69485251
187Constricted visual fields (HP:0001133)1.69296929
188Short nail (HP:0001799)1.69168482
189Distal lower limb amyotrophy (HP:0008944)1.68973489
190Duodenal stenosis (HP:0100867)1.67936591
191Small intestinal stenosis (HP:0012848)1.67936591
192Bone pain (HP:0002653)1.67285741
193Recurrent gram-negative bacterial infections (HP:0005420)1.66711674
194Hypothermia (HP:0002045)1.64163651
195Retinitis pigmentosa (HP:0000510)1.63932426
196Hypergonadotropic hypogonadism (HP:0000815)1.62920661
197Oligohydramnios (HP:0001562)1.62787010
198Xerostomia (HP:0000217)1.62471594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.61132294
2DDR23.44678378
3TXK3.41324033
4IRAK43.19974604
5PBK3.05396607
6NME23.03249171
7IRAK33.02469262
8MAP3K142.92360627
9CASK2.47539874
10TRIB32.41682633
11ADRBK22.32175991
12PDGFRA2.26220946
13ERN12.23660278
14YES12.23481812
15SMG12.12066358
16TTN2.09748521
17GRK11.95386329
18PLK41.94449752
19TGFBR21.92912049
20ICK1.89132988
21MAP3K131.87979026
22NEK61.87625011
23SIK11.85608221
24EIF2AK21.83877721
25NUAK11.80198522
26STK161.73169729
27CDC42BPA1.70843499
28IKBKB1.68235048
29EEF2K1.67644721
30IKBKE1.64148095
31PINK11.62493927
32BLK1.61170029
33GRK71.52745864
34TNIK1.50500884
35BMPR21.48197478
36MKNK11.47991654
37EPHA21.45719585
38KIT1.42508936
39MKNK21.41101725
40PRKD21.40613684
41MAP2K31.40268829
42TEC1.37522956
43PAK21.36520678
44SIK31.35791431
45SRPK11.30792436
46MOS1.30518656
47BMPR1B1.27386659
48STK41.26273491
49TESK21.23966049
50JAK31.23306817
51NEK91.22420769
52IRAK21.17441254
53MYLK1.15394435
54TESK11.15384166
55AKT31.15035925
56CLK11.13352064
57CSF1R1.09285529
58MATK1.06686197
59CHUK1.06025909
60CDK61.05699642
61SGK21.05428125
62PRPF4B1.05086366
63CDK31.04916871
64RIPK41.02408058
65STK38L1.01620425
66MAP4K11.00151382
67SIK20.98806379
68LIMK10.98655024
69ABL20.95854482
70VRK10.94293257
71MAP2K70.92772205
72CDK40.92463445
73IRAK10.92322200
74PAK40.91969576
75RPS6KA20.91633827
76PKN20.91271954
77INSRR0.89699085
78NLK0.89613718
79ATR0.87070400
80TYK20.86097073
81RIPK10.83854576
82MAPK110.81978086
83BTK0.81467912
84EPHA30.81407844
85MTOR0.81293271
86PKN10.81289677
87ERBB30.79864263
88LYN0.79841239
89TRPM70.79678480
90STK240.78879762
91PIM20.77780737
92TTK0.77639261
93RPS6KC10.77527223
94RPS6KL10.77527223
95MELK0.77323859
96MAP3K30.77061500
97MAP3K80.76596632
98PIM10.74982371
99MAPK70.74143500
100TBK10.73618172
101LATS20.73111370
102JAK10.72904000
103MAPK130.69487208
104MAP3K110.69357681
105BRD40.67613599
106TNK20.66060576
107TAOK20.65151623
108PDGFRB0.65036486
109STK100.64438410
110TAOK30.63610914
111CHEK20.63554835
112SYK0.63458096
113TGFBR10.63126522
114PIK3CA0.62477667
115PTK20.62148725
116ARAF0.61958593
117ZAP700.61782852
118LCK0.61406273
119TIE10.61244869
120CCNB10.60831986
121RPS6KA50.58767425
122RPS6KA60.58760941
123PLK20.56973290
124CSK0.56842606
125FGR0.56812127
126CAMK1D0.56064600
127FGFR40.54782092
128EIF2AK30.54736085
129PIK3CG0.54622715
130CDK90.53706960
131FLT30.53588421
132HCK0.53414243
133PLK30.53120178
134PDPK10.53083864
135MAPK40.51713068
136SGK2230.51620532
137SGK4940.51620532
138CDK80.51111563
139DAPK30.50786364
140STK30.49661785
141SGK30.49202144
142PRKCE0.46928866
143KSR20.46250242
144CAMKK20.46013537
145CDK70.44921425
146MARK30.43497125
147TAOK10.42652389
148MAP3K10.40542990
149PDK20.39822827
150MUSK0.39165209
151CDK120.38638072
152CAMK1G0.38461117
153MAPK120.38308665
154MAP3K100.37866689
155ATM0.37683820
156BCR0.36318295
157HIPK20.35481159
158MAP3K50.34224476
159TYRO30.33662803
160ABL10.32586953
161MAP2K60.32511142
162PRKCD0.28659086
163MAPK30.28052770
164MAPKAPK20.27768019
165DYRK1A0.26507048
166PRKCQ0.26446878

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.22995529
2Fanconi anemia pathway_Homo sapiens_hsa034602.50656936
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.50313767
4Graft-versus-host disease_Homo sapiens_hsa053322.25537945
5Allograft rejection_Homo sapiens_hsa053302.18035641
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03509621
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.01340759
8Homologous recombination_Homo sapiens_hsa034401.99841295
9Non-homologous end-joining_Homo sapiens_hsa034501.98914509
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.95558567
11Asthma_Homo sapiens_hsa053101.91060973
12Autoimmune thyroid disease_Homo sapiens_hsa053201.90617004
13Bladder cancer_Homo sapiens_hsa052191.87228487
14Rheumatoid arthritis_Homo sapiens_hsa053231.75381757
15B cell receptor signaling pathway_Homo sapiens_hsa046621.72440481
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68985206
17Measles_Homo sapiens_hsa051621.66955161
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.65003840
19Primary immunodeficiency_Homo sapiens_hsa053401.63141607
20Hematopoietic cell lineage_Homo sapiens_hsa046401.57713800
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57025377
22Leishmaniasis_Homo sapiens_hsa051401.55454871
23RNA polymerase_Homo sapiens_hsa030201.54834986
24Other glycan degradation_Homo sapiens_hsa005111.49121404
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48945744
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47721594
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46515459
28Sphingolipid metabolism_Homo sapiens_hsa006001.44944792
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.42051861
30Acute myeloid leukemia_Homo sapiens_hsa052211.41342890
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37811259
32Chronic myeloid leukemia_Homo sapiens_hsa052201.35304249
33Basal transcription factors_Homo sapiens_hsa030221.33029808
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27233376
35Phagosome_Homo sapiens_hsa041451.24964170
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24488011
37Prion diseases_Homo sapiens_hsa050201.23029369
38Arachidonic acid metabolism_Homo sapiens_hsa005901.22248210
39Herpes simplex infection_Homo sapiens_hsa051681.21837487
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.21631729
41Malaria_Homo sapiens_hsa051441.15903907
42Mismatch repair_Homo sapiens_hsa034301.14235916
43Amoebiasis_Homo sapiens_hsa051461.13741013
44Steroid biosynthesis_Homo sapiens_hsa001001.12000449
45Osteoclast differentiation_Homo sapiens_hsa043801.10912146
46Base excision repair_Homo sapiens_hsa034101.09607093
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06122592
48Focal adhesion_Homo sapiens_hsa045101.05611256
49Small cell lung cancer_Homo sapiens_hsa052221.04739586
50Influenza A_Homo sapiens_hsa051641.04235511
51Type I diabetes mellitus_Homo sapiens_hsa049401.04226777
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.03562112
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02535069
54Tuberculosis_Homo sapiens_hsa051521.01547405
55HTLV-I infection_Homo sapiens_hsa051661.00831193
56Pertussis_Homo sapiens_hsa051331.00219050
57Proteoglycans in cancer_Homo sapiens_hsa052050.99752682
58Pancreatic cancer_Homo sapiens_hsa052120.99637965
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96148601
60Ether lipid metabolism_Homo sapiens_hsa005650.95608812
61TNF signaling pathway_Homo sapiens_hsa046680.95527475
62Legionellosis_Homo sapiens_hsa051340.95106886
63DNA replication_Homo sapiens_hsa030300.94396822
64Collecting duct acid secretion_Homo sapiens_hsa049660.93769169
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93415264
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92270867
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.92129114
68Pyrimidine metabolism_Homo sapiens_hsa002400.90198613
69Purine metabolism_Homo sapiens_hsa002300.83797072
70Chemokine signaling pathway_Homo sapiens_hsa040620.83068250
71Staphylococcus aureus infection_Homo sapiens_hsa051500.82620837
72Viral carcinogenesis_Homo sapiens_hsa052030.82165754
73MicroRNAs in cancer_Homo sapiens_hsa052060.81888897
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.78842122
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77483798
76VEGF signaling pathway_Homo sapiens_hsa043700.76725882
77Non-small cell lung cancer_Homo sapiens_hsa052230.76667673
78mTOR signaling pathway_Homo sapiens_hsa041500.76594046
79ECM-receptor interaction_Homo sapiens_hsa045120.76489938
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76123515
81Prostate cancer_Homo sapiens_hsa052150.76044568
82Apoptosis_Homo sapiens_hsa042100.74516195
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74060407
84Vitamin digestion and absorption_Homo sapiens_hsa049770.73409017
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73370684
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71859948
87p53 signaling pathway_Homo sapiens_hsa041150.70276085
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.69680598
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69632478
90Toxoplasmosis_Homo sapiens_hsa051450.69091023
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68855283
92RNA degradation_Homo sapiens_hsa030180.68009479
93Renal cell carcinoma_Homo sapiens_hsa052110.67362547
94Serotonergic synapse_Homo sapiens_hsa047260.64267673
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63460740
96Nucleotide excision repair_Homo sapiens_hsa034200.63402044
97Ovarian steroidogenesis_Homo sapiens_hsa049130.61041448
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60265132
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.59863732
100Melanoma_Homo sapiens_hsa052180.57316359
101Endocytosis_Homo sapiens_hsa041440.56719698
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.56151434
103Linoleic acid metabolism_Homo sapiens_hsa005910.55909790
104Glioma_Homo sapiens_hsa052140.55521217
105Antigen processing and presentation_Homo sapiens_hsa046120.55117438
106Salmonella infection_Homo sapiens_hsa051320.53313580
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.52899906
108Viral myocarditis_Homo sapiens_hsa054160.52835737
109African trypanosomiasis_Homo sapiens_hsa051430.51225738
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50598028
111Lysosome_Homo sapiens_hsa041420.49602152
112GnRH signaling pathway_Homo sapiens_hsa049120.49474409
113Pentose phosphate pathway_Homo sapiens_hsa000300.48996502
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48210743
115HIF-1 signaling pathway_Homo sapiens_hsa040660.47829148
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47438297
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.46758740
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46503566
119Taste transduction_Homo sapiens_hsa047420.46072914
120Hepatitis B_Homo sapiens_hsa051610.45664408
121Hepatitis C_Homo sapiens_hsa051600.45076600
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43641241
123MAPK signaling pathway_Homo sapiens_hsa040100.43538472
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43531550
125Platelet activation_Homo sapiens_hsa046110.43411102
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43311433
127Morphine addiction_Homo sapiens_hsa050320.43289038
128Pathways in cancer_Homo sapiens_hsa052000.42083947
129Epstein-Barr virus infection_Homo sapiens_hsa051690.41146505
130Protein export_Homo sapiens_hsa030600.40999647
131Regulation of autophagy_Homo sapiens_hsa041400.39973357
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39627203
133T cell receptor signaling pathway_Homo sapiens_hsa046600.39284778
134Nicotine addiction_Homo sapiens_hsa050330.37880229
135Shigellosis_Homo sapiens_hsa051310.37539092
136Renin-angiotensin system_Homo sapiens_hsa046140.36690191
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35712452
138Retinol metabolism_Homo sapiens_hsa008300.34604286
139Cell cycle_Homo sapiens_hsa041100.34157242
140One carbon pool by folate_Homo sapiens_hsa006700.33918954
141Vibrio cholerae infection_Homo sapiens_hsa051100.33702905
142Proteasome_Homo sapiens_hsa030500.31001922
143Prolactin signaling pathway_Homo sapiens_hsa049170.30461104

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