

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.91886818 |
| 2 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.81524208 |
| 3 | nucleobase biosynthetic process (GO:0046112) | 4.69658944 |
| 4 | DNA strand elongation (GO:0022616) | 4.64580088 |
| 5 | DNA replication initiation (GO:0006270) | 4.63487797 |
| 6 | formation of translation preinitiation complex (GO:0001731) | 4.61608076 |
| 7 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.58899149 |
| 8 | DNA deamination (GO:0045006) | 4.55060098 |
| 9 | DNA unwinding involved in DNA replication (GO:0006268) | 4.44808113 |
| 10 | purine nucleobase biosynthetic process (GO:0009113) | 4.36302690 |
| 11 | ribosomal small subunit assembly (GO:0000028) | 4.32766553 |
| 12 | DNA replication checkpoint (GO:0000076) | 4.22215323 |
| 13 | maturation of SSU-rRNA (GO:0030490) | 4.14449627 |
| 14 | protein localization to kinetochore (GO:0034501) | 4.13370773 |
| 15 | IMP biosynthetic process (GO:0006188) | 4.01682026 |
| 16 | telomere maintenance via recombination (GO:0000722) | 3.99503907 |
| 17 | ribosome biogenesis (GO:0042254) | 3.99394691 |
| 18 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.94014069 |
| 19 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.94014069 |
| 20 | mitotic metaphase plate congression (GO:0007080) | 3.93574535 |
| 21 | establishment of viral latency (GO:0019043) | 3.86517038 |
| 22 | ribosome assembly (GO:0042255) | 3.84923354 |
| 23 | viral transcription (GO:0019083) | 3.81613305 |
| 24 | translational termination (GO:0006415) | 3.80839173 |
| 25 | IMP metabolic process (GO:0046040) | 3.77026238 |
| 26 | mitotic nuclear envelope disassembly (GO:0007077) | 3.76897377 |
| 27 | regulation of mitochondrial translation (GO:0070129) | 3.73201404 |
| 28 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.72827992 |
| 29 | mitotic recombination (GO:0006312) | 3.70057507 |
| 30 | translational elongation (GO:0006414) | 3.69395873 |
| 31 | translational initiation (GO:0006413) | 3.61061642 |
| 32 | telomere maintenance via telomere lengthening (GO:0010833) | 3.60458457 |
| 33 | proteasome assembly (GO:0043248) | 3.59766030 |
| 34 | spliceosomal snRNP assembly (GO:0000387) | 3.59231941 |
| 35 | proline biosynthetic process (GO:0006561) | 3.58713719 |
| 36 | ribosomal large subunit biogenesis (GO:0042273) | 3.58486675 |
| 37 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.56185554 |
| 38 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.55926821 |
| 39 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.55628351 |
| 40 | regulation of translational fidelity (GO:0006450) | 3.52472773 |
| 41 | pseudouridine synthesis (GO:0001522) | 3.51721170 |
| 42 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.50765833 |
| 43 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.50605942 |
| 44 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.49649696 |
| 45 | nuclear envelope disassembly (GO:0051081) | 3.49307744 |
| 46 | membrane disassembly (GO:0030397) | 3.49307744 |
| 47 | folic acid metabolic process (GO:0046655) | 3.48979155 |
| 48 | protein maturation by protein folding (GO:0022417) | 3.48863094 |
| 49 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.46121060 |
| 50 | CENP-A containing nucleosome assembly (GO:0034080) | 3.45586182 |
| 51 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.45529811 |
| 52 | rRNA processing (GO:0006364) | 3.44724058 |
| 53 | chromatin remodeling at centromere (GO:0031055) | 3.43208326 |
| 54 | ribosomal small subunit biogenesis (GO:0042274) | 3.43135547 |
| 55 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.43128941 |
| 56 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.40051224 |
| 57 | protein localization to chromosome, centromeric region (GO:0071459) | 3.39382847 |
| 58 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.37589028 |
| 59 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.34367454 |
| 60 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.33886193 |
| 61 | rRNA metabolic process (GO:0016072) | 3.31942897 |
| 62 | metaphase plate congression (GO:0051310) | 3.31896145 |
| 63 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.28897772 |
| 64 | protein deneddylation (GO:0000338) | 3.27698699 |
| 65 | negative regulation of ligase activity (GO:0051352) | 3.26888157 |
| 66 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.26888157 |
| 67 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.25583410 |
| 68 | maturation of 5.8S rRNA (GO:0000460) | 3.24371620 |
| 69 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.23400892 |
| 70 | nuclear pore complex assembly (GO:0051292) | 3.22386190 |
| 71 | DNA replication-independent nucleosome organization (GO:0034724) | 3.22317375 |
| 72 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.22317375 |
| 73 | Golgi transport vesicle coating (GO:0048200) | 3.21876681 |
| 74 | COPI coating of Golgi vesicle (GO:0048205) | 3.21876681 |
| 75 | cullin deneddylation (GO:0010388) | 3.20554859 |
| 76 | mitotic chromosome condensation (GO:0007076) | 3.19574267 |
| 77 | rRNA modification (GO:0000154) | 3.19413717 |
| 78 | mitotic sister chromatid segregation (GO:0000070) | 3.19352186 |
| 79 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.18907757 |
| 80 | cell cycle G1/S phase transition (GO:0044843) | 3.18907757 |
| 81 | histone arginine methylation (GO:0034969) | 3.16714667 |
| 82 | de novo protein folding (GO:0006458) | 3.15420822 |
| 83 | viral mRNA export from host cell nucleus (GO:0046784) | 3.15290217 |
| 84 | cotranslational protein targeting to membrane (GO:0006613) | 3.14257507 |
| 85 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.13564297 |
| 86 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.13487369 |
| 87 | protein targeting to ER (GO:0045047) | 3.13251171 |
| 88 | establishment of integrated proviral latency (GO:0075713) | 3.11685129 |
| 89 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.10801229 |
| 90 | nuclear envelope reassembly (GO:0031468) | 3.10734622 |
| 91 | mitotic nuclear envelope reassembly (GO:0007084) | 3.10734622 |
| 92 | de novo posttranslational protein folding (GO:0051084) | 3.09600558 |
| 93 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.08274285 |
| 94 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.08274285 |
| 95 | cellular protein complex disassembly (GO:0043624) | 3.07376274 |
| 96 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.07224290 |
| 97 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.06674496 |
| 98 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.06674496 |
| 99 | sister chromatid segregation (GO:0000819) | 3.05196379 |
| 100 | protein complex localization (GO:0031503) | 3.05007279 |
| 101 | regulation of translational termination (GO:0006449) | 3.04269374 |
| 102 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.04075574 |
| 103 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.04075574 |
| 104 | establishment of chromosome localization (GO:0051303) | 3.03347663 |
| 105 | tRNA aminoacylation (GO:0043039) | 3.02750924 |
| 106 | amino acid activation (GO:0043038) | 3.02750924 |
| 107 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.02456824 |
| 108 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.02456824 |
| 109 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.02456824 |
| 110 | translation (GO:0006412) | 3.01913434 |
| 111 | negative regulation of mRNA processing (GO:0050686) | 3.01469336 |
| 112 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.99888163 |
| 113 | protein localization to endoplasmic reticulum (GO:0070972) | 2.99779240 |
| 114 | viral life cycle (GO:0019058) | 2.98416228 |
| 115 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.98053805 |
| 116 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.96741726 |
| 117 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.95964715 |
| 118 | L-methionine salvage (GO:0071267) | 2.95501255 |
| 119 | L-methionine biosynthetic process (GO:0071265) | 2.95501255 |
| 120 | amino acid salvage (GO:0043102) | 2.95501255 |
| 121 | rRNA transcription (GO:0009303) | 2.95344430 |
| 122 | non-recombinational repair (GO:0000726) | 2.94985623 |
| 123 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.94985623 |
| 124 | pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130) | 2.94424390 |
| 125 | tRNA aminoacylation for protein translation (GO:0006418) | 2.93984441 |
| 126 | positive regulation of ligase activity (GO:0051351) | 2.93874432 |
| 127 | spliceosomal complex assembly (GO:0000245) | 2.93636531 |
| 128 | cellular component biogenesis (GO:0044085) | 2.92716492 |
| 129 | DNA duplex unwinding (GO:0032508) | 2.90868846 |
| 130 | DNA damage response, detection of DNA damage (GO:0042769) | 2.89569895 |
| 131 | nuclear pore organization (GO:0006999) | 2.88633502 |
| 132 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.88572916 |
| 133 | regulation of ligase activity (GO:0051340) | 2.84941032 |
| 134 | mitochondrial RNA metabolic process (GO:0000959) | 2.84875332 |
| 135 | peptidyl-arginine methylation (GO:0018216) | 2.84282327 |
| 136 | peptidyl-arginine N-methylation (GO:0035246) | 2.84282327 |
| 137 | base-excision repair (GO:0006284) | 2.82614389 |
| 138 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.79254266 |
| 139 | protein targeting to mitochondrion (GO:0006626) | 2.77961623 |
| 140 | mitochondrial fusion (GO:0008053) | 2.77345975 |
| 141 | oxidative phosphorylation (GO:0006119) | 2.75929532 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.26133988 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.44012360 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.33480690 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.27158273 |
| 5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.13434948 |
| 6 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.07067391 |
| 7 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.04911683 |
| 8 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.01711527 |
| 9 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.01490371 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.00105206 |
| 11 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.97996532 |
| 12 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.93178363 |
| 13 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.87255350 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.77115469 |
| 15 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.73198645 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.63489529 |
| 17 | * NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.44402560 |
| 18 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.41683589 |
| 19 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.35992270 |
| 20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.21765411 |
| 21 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.19487714 |
| 22 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.17312913 |
| 23 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.13122551 |
| 24 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.07098054 |
| 25 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.05023760 |
| 26 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.04678666 |
| 27 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.97036945 |
| 28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.94757292 |
| 29 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.87271217 |
| 30 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.85032423 |
| 31 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.84384759 |
| 32 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.78186305 |
| 33 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.77982496 |
| 34 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.75493359 |
| 35 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.75197374 |
| 36 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.74879043 |
| 37 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.74622401 |
| 38 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.72973079 |
| 39 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.72700877 |
| 40 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.70656317 |
| 41 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.70339076 |
| 42 | * MYC_22102868_ChIP-Seq_BL_Human | 1.64728667 |
| 43 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.63709421 |
| 44 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.62789952 |
| 45 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.58803923 |
| 46 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.57406646 |
| 47 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.50381713 |
| 48 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.50364010 |
| 49 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.49944113 |
| 50 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.49102250 |
| 51 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.48813731 |
| 52 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.46615513 |
| 53 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.43733449 |
| 54 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.42742125 |
| 55 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.42658272 |
| 56 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.40401424 |
| 57 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.31340941 |
| 58 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.31139071 |
| 59 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.30923484 |
| 60 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28421476 |
| 61 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.27592346 |
| 62 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.26078156 |
| 63 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.24525619 |
| 64 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.24341793 |
| 65 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.23757209 |
| 66 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.22933174 |
| 67 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.20112621 |
| 68 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.18191473 |
| 69 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.16959872 |
| 70 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.16850812 |
| 71 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.16386455 |
| 72 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.16337899 |
| 73 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.15951208 |
| 74 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.12681406 |
| 75 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.11700159 |
| 76 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.09172028 |
| 77 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.06776064 |
| 78 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.06103841 |
| 79 | * ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.05266152 |
| 80 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.05259353 |
| 81 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.04500247 |
| 82 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.00949549 |
| 83 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 1.00827116 |
| 84 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.00663499 |
| 85 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.99902711 |
| 86 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.99563645 |
| 87 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.98490434 |
| 88 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.98362314 |
| 89 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.97725601 |
| 90 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.96873778 |
| 91 | * MYC_18940864_ChIP-ChIP_HL60_Human | 0.96759412 |
| 92 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.95164012 |
| 93 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.94837301 |
| 94 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.94327521 |
| 95 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.93409697 |
| 96 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.93196866 |
| 97 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.92787739 |
| 98 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.92406701 |
| 99 | * HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.91367486 |
| 100 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.91333901 |
| 101 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.91240635 |
| 102 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.90928443 |
| 103 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.89397776 |
| 104 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.89330526 |
| 105 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.88266288 |
| 106 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.88174696 |
| 107 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.87371738 |
| 108 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.85648503 |
| 109 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.85621846 |
| 110 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.84428410 |
| 111 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.84291599 |
| 112 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.83127700 |
| 113 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.82431963 |
| 114 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.81448730 |
| 115 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.81341933 |
| 116 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.81324062 |
| 117 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.80983154 |
| 118 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.80819114 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 6.06585125 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 5.08893088 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.71174830 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.47795357 |
| 5 | MP0003077_abnormal_cell_cycle | 4.16347634 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 4.14036899 |
| 7 | MP0008058_abnormal_DNA_repair | 3.22274018 |
| 8 | MP0008057_abnormal_DNA_replication | 3.17661902 |
| 9 | MP0003123_paternal_imprinting | 3.11374069 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.83028053 |
| 11 | MP0001730_embryonic_growth_arrest | 2.76361137 |
| 12 | MP0008007_abnormal_cellular_replicative | 2.69263169 |
| 13 | MP0002396_abnormal_hematopoietic_system | 2.30686791 |
| 14 | MP0000350_abnormal_cell_proliferation | 2.26657473 |
| 15 | MP0010352_gastrointestinal_tract_polyps | 2.18241586 |
| 16 | MP0003718_maternal_effect | 2.09279173 |
| 17 | MP0008877_abnormal_DNA_methylation | 1.99934503 |
| 18 | MP0003786_premature_aging | 1.91091836 |
| 19 | MP0010307_abnormal_tumor_latency | 1.89227991 |
| 20 | MP0002877_abnormal_melanocyte_morpholog | 1.86267747 |
| 21 | MP0001697_abnormal_embryo_size | 1.85733894 |
| 22 | MP0006036_abnormal_mitochondrial_physio | 1.82846810 |
| 23 | MP0002080_prenatal_lethality | 1.79898666 |
| 24 | MP0003186_abnormal_redox_activity | 1.75536051 |
| 25 | MP0001672_abnormal_embryogenesis/_devel | 1.75000328 |
| 26 | MP0005380_embryogenesis_phenotype | 1.75000328 |
| 27 | MP0010234_abnormal_vibrissa_follicle | 1.72899204 |
| 28 | MP0003656_abnormal_erythrocyte_physiolo | 1.72794036 |
| 29 | MP0000490_abnormal_crypts_of | 1.72159905 |
| 30 | MP0005501_abnormal_skin_physiology | 1.66251925 |
| 31 | MP0002019_abnormal_tumor_incidence | 1.63268244 |
| 32 | MP0003984_embryonic_growth_retardation | 1.58475036 |
| 33 | MP0000313_abnormal_cell_death | 1.56468461 |
| 34 | MP0002088_abnormal_embryonic_growth/wei | 1.54057673 |
| 35 | MP0000678_abnormal_parathyroid_gland | 1.51532624 |
| 36 | MP0000358_abnormal_cell_content/ | 1.45149588 |
| 37 | MP0002085_abnormal_embryonic_tissue | 1.43516670 |
| 38 | MP0006035_abnormal_mitochondrial_morpho | 1.38645884 |
| 39 | MP0002796_impaired_skin_barrier | 1.38501726 |
| 40 | MP0003221_abnormal_cardiomyocyte_apopto | 1.38062587 |
| 41 | MP0002086_abnormal_extraembryonic_tissu | 1.34773883 |
| 42 | MP0009333_abnormal_splenocyte_physiolog | 1.34474960 |
| 43 | MP0001529_abnormal_vocalization | 1.31257029 |
| 44 | MP0002084_abnormal_developmental_patter | 1.30758192 |
| 45 | MP0006054_spinal_hemorrhage | 1.30241046 |
| 46 | MP0008260_abnormal_autophagy | 1.28854621 |
| 47 | MP0009840_abnormal_foam_cell | 1.28676126 |
| 48 | MP0005623_abnormal_meninges_morphology | 1.26779693 |
| 49 | MP0004185_abnormal_adipocyte_glucose | 1.26539655 |
| 50 | MP0001727_abnormal_embryo_implantation | 1.21623675 |
| 51 | MP0003121_genomic_imprinting | 1.21099639 |
| 52 | MP0001545_abnormal_hematopoietic_system | 1.19245118 |
| 53 | MP0005397_hematopoietic_system_phenotyp | 1.19245118 |
| 54 | MP0004808_abnormal_hematopoietic_stem | 1.17261011 |
| 55 | MP0002653_abnormal_ependyma_morphology | 1.16750891 |
| 56 | MP0004197_abnormal_fetal_growth/weight/ | 1.15057748 |
| 57 | MP0002234_abnormal_pharynx_morphology | 1.14699980 |
| 58 | MP0005266_abnormal_metabolism | 1.13939795 |
| 59 | MP0002269_muscular_atrophy | 1.11016169 |
| 60 | MP0001346_abnormal_lacrimal_gland | 1.10698915 |
| 61 | MP0000762_abnormal_tongue_morphology | 1.07422069 |
| 62 | MP0008875_abnormal_xenobiotic_pharmacok | 1.03037202 |
| 63 | MP0004147_increased_porphyrin_level | 1.01930648 |
| 64 | MP0001661_extended_life_span | 1.00981676 |
| 65 | MP0000689_abnormal_spleen_morphology | 1.00198475 |
| 66 | MP0003646_muscle_fatigue | 0.99332265 |
| 67 | MP0002722_abnormal_immune_system | 0.99286014 |
| 68 | MP0003567_abnormal_fetal_cardiomyocyte | 0.97305638 |
| 69 | MP0002210_abnormal_sex_determination | 0.97197603 |
| 70 | MP0003763_abnormal_thymus_physiology | 0.96192914 |
| 71 | MP0000467_abnormal_esophagus_morphology | 0.96158082 |
| 72 | MP0005075_abnormal_melanosome_morpholog | 0.95996331 |
| 73 | MP0009053_abnormal_anal_canal | 0.95118737 |
| 74 | MP0002398_abnormal_bone_marrow | 0.94716708 |
| 75 | MP0001145_abnormal_male_reproductive | 0.94526774 |
| 76 | MP0000703_abnormal_thymus_morphology | 0.94278494 |
| 77 | MP0005384_cellular_phenotype | 0.93861820 |
| 78 | MP0002160_abnormal_reproductive_system | 0.89895651 |
| 79 | MP0009672_abnormal_birth_weight | 0.88926516 |
| 80 | MP0004084_abnormal_cardiac_muscle | 0.85657145 |
| 81 | MP0010030_abnormal_orbit_morphology | 0.85263929 |
| 82 | MP0003890_abnormal_embryonic-extraembry | 0.85173918 |
| 83 | MP0000627_abnormal_mammary_gland | 0.84647460 |
| 84 | MP0000858_altered_metastatic_potential | 0.84199406 |
| 85 | MP0003315_abnormal_perineum_morphology | 0.83271683 |
| 86 | MP0002161_abnormal_fertility/fecundity | 0.83180178 |
| 87 | MP0000653_abnormal_sex_gland | 0.83160031 |
| 88 | MP0003937_abnormal_limbs/digits/tail_de | 0.81872016 |
| 89 | MP0001929_abnormal_gametogenesis | 0.80314016 |
| 90 | MP0004264_abnormal_extraembryonic_tissu | 0.79539895 |
| 91 | MP0005621_abnormal_cell_physiology | 0.79480345 |
| 92 | MP0001881_abnormal_mammary_gland | 0.79390738 |
| 93 | MP0001764_abnormal_homeostasis | 0.78866009 |
| 94 | MP0002429_abnormal_blood_cell | 0.78631672 |
| 95 | MP0008789_abnormal_olfactory_epithelium | 0.78532384 |
| 96 | MP0004233_abnormal_muscle_weight | 0.78334419 |
| 97 | MP0005023_abnormal_wound_healing | 0.77948632 |
| 98 | MP0000579_abnormal_nail_morphology | 0.77336023 |
| 99 | MP0003941_abnormal_skin_development | 0.76884332 |
| 100 | MP0000598_abnormal_liver_morphology | 0.76213721 |
| 101 | MP0001915_intracranial_hemorrhage | 0.76080448 |
| 102 | MP0002098_abnormal_vibrissa_morphology | 0.76037760 |
| 103 | MP0005394_taste/olfaction_phenotype | 0.75805761 |
| 104 | MP0005499_abnormal_olfactory_system | 0.75805761 |
| 105 | MP0001849_ear_inflammation | 0.74070621 |
| 106 | MP0000747_muscle_weakness | 0.73137113 |
| 107 | MP0000566_synostosis | 0.71549745 |
| 108 | MP0001216_abnormal_epidermal_layer | 0.71341757 |
| 109 | MP0003119_abnormal_digestive_system | 0.71263957 |
| 110 | MP0005389_reproductive_system_phenotype | 0.70977399 |
| 111 | MP0005076_abnormal_cell_differentiation | 0.70417961 |
| 112 | MP0001293_anophthalmia | 0.70395970 |
| 113 | MP0000750_abnormal_muscle_regeneration | 0.69584236 |
| 114 | MP0002132_abnormal_respiratory_system | 0.68929481 |
| 115 | MP0010771_integument_phenotype | 0.68812950 |
| 116 | MP0000049_abnormal_middle_ear | 0.68403826 |
| 117 | MP0003698_abnormal_male_reproductive | 0.67525597 |
| 118 | MP0002111_abnormal_tail_morphology | 0.67065974 |
| 119 | MP0000477_abnormal_intestine_morphology | 0.67049697 |
| 120 | MP0006292_abnormal_olfactory_placode | 0.66459461 |
| 121 | MP0001853_heart_inflammation | 0.65839162 |
| 122 | MP0001119_abnormal_female_reproductive | 0.62541279 |
| 123 | MP0000537_abnormal_urethra_morphology | 0.62193025 |
| 124 | MP0008995_early_reproductive_senescence | 0.61286841 |
| 125 | MP0002060_abnormal_skin_morphology | 0.60917821 |
| 126 | MP0002697_abnormal_eye_size | 0.60891566 |
| 127 | MP0001348_abnormal_lacrimal_gland | 0.60196928 |
| 128 | MP0004133_heterotaxia | 0.59785598 |
| 129 | MP0005451_abnormal_body_composition | 0.59138677 |
| 130 | MP0003566_abnormal_cell_adhesion | 0.58145425 |
| 131 | MP0003699_abnormal_female_reproductive | 0.57953258 |
| 132 | MP0005408_hypopigmentation | 0.57729395 |
| 133 | MP0008873_increased_physiological_sensi | 0.56971266 |
| 134 | MP0009697_abnormal_copulation | 0.56647081 |
| 135 | MP0005319_abnormal_enzyme/_coenzyme | 0.55986206 |
| 136 | MP0005330_cardiomyopathy | 0.55198505 |
| 137 | MP0003705_abnormal_hypodermis_morpholog | 0.54432846 |
| 138 | MP0000749_muscle_degeneration | 0.54125470 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.00276315 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 4.87312936 |
| 3 | Birth length less than 3rd percentile (HP:0003561) | 4.61030153 |
| 4 | Oral leukoplakia (HP:0002745) | 4.15211355 |
| 5 | Cerebral hypomyelination (HP:0006808) | 4.07683909 |
| 6 | Reticulocytopenia (HP:0001896) | 3.91030839 |
| 7 | Microvesicular hepatic steatosis (HP:0001414) | 3.80016962 |
| 8 | Breast hypoplasia (HP:0003187) | 3.72690637 |
| 9 | Selective tooth agenesis (HP:0001592) | 3.52151637 |
| 10 | Aplastic anemia (HP:0001915) | 3.49324264 |
| 11 | Multiple enchondromatosis (HP:0005701) | 3.35327253 |
| 12 | Microretrognathia (HP:0000308) | 3.33511780 |
| 13 | Abnormality of the anterior horn cell (HP:0006802) | 3.20405537 |
| 14 | Degeneration of anterior horn cells (HP:0002398) | 3.20405537 |
| 15 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.17637815 |
| 16 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.17637815 |
| 17 | Ependymoma (HP:0002888) | 3.11975822 |
| 18 | Abnormality of glycolysis (HP:0004366) | 3.08769655 |
| 19 | Increased serum pyruvate (HP:0003542) | 3.08769655 |
| 20 | Abnormal gallbladder physiology (HP:0012438) | 3.06938716 |
| 21 | Cholecystitis (HP:0001082) | 3.06938716 |
| 22 | Agnosia (HP:0010524) | 3.06204906 |
| 23 | Colon cancer (HP:0003003) | 3.00797726 |
| 24 | Macrocytic anemia (HP:0001972) | 2.96617565 |
| 25 | Carpal bone hypoplasia (HP:0001498) | 2.92101644 |
| 26 | Rough bone trabeculation (HP:0100670) | 2.90874114 |
| 27 | Shoulder girdle muscle weakness (HP:0003547) | 2.88680567 |
| 28 | Hepatocellular necrosis (HP:0001404) | 2.85125229 |
| 29 | Increased serum lactate (HP:0002151) | 2.82613021 |
| 30 | Patellar aplasia (HP:0006443) | 2.76934490 |
| 31 | Hepatic necrosis (HP:0002605) | 2.66626422 |
| 32 | Rhabdomyosarcoma (HP:0002859) | 2.65563947 |
| 33 | Pallor (HP:0000980) | 2.63383048 |
| 34 | Medulloblastoma (HP:0002885) | 2.62215396 |
| 35 | Progressive muscle weakness (HP:0003323) | 2.61586828 |
| 36 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.60177250 |
| 37 | Hypokinesia (HP:0002375) | 2.54900968 |
| 38 | Sparse eyelashes (HP:0000653) | 2.51875012 |
| 39 | Premature graying of hair (HP:0002216) | 2.51794993 |
| 40 | Premature ovarian failure (HP:0008209) | 2.51173405 |
| 41 | Increased CSF lactate (HP:0002490) | 2.50413656 |
| 42 | Chromsome breakage (HP:0040012) | 2.50265294 |
| 43 | Testicular atrophy (HP:0000029) | 2.48563142 |
| 44 | Abnormality of the preputium (HP:0100587) | 2.45935931 |
| 45 | CNS hypomyelination (HP:0003429) | 2.45710319 |
| 46 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.44740208 |
| 47 | Thrombocytosis (HP:0001894) | 2.44434067 |
| 48 | Meckel diverticulum (HP:0002245) | 2.41192739 |
| 49 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.40707202 |
| 50 | Postnatal microcephaly (HP:0005484) | 2.40160923 |
| 51 | Proximal placement of thumb (HP:0009623) | 2.39561624 |
| 52 | Trismus (HP:0000211) | 2.38806822 |
| 53 | Abnormality of chromosome stability (HP:0003220) | 2.38384456 |
| 54 | Secondary amenorrhea (HP:0000869) | 2.38066255 |
| 55 | Absent thumb (HP:0009777) | 2.36303697 |
| 56 | Abnormality of the labia minora (HP:0012880) | 2.35797549 |
| 57 | Megaloblastic anemia (HP:0001889) | 2.34893876 |
| 58 | Emotional lability (HP:0000712) | 2.32779840 |
| 59 | Deviation of the thumb (HP:0009603) | 2.32291378 |
| 60 | Abnormality of the ileum (HP:0001549) | 2.30660254 |
| 61 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.30589796 |
| 62 | Male infertility (HP:0003251) | 2.30576534 |
| 63 | Neoplasm of the pancreas (HP:0002894) | 2.29845825 |
| 64 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.29370762 |
| 65 | Myelodysplasia (HP:0002863) | 2.27262835 |
| 66 | Insomnia (HP:0100785) | 2.27038570 |
| 67 | CNS demyelination (HP:0007305) | 2.25459294 |
| 68 | Ragged-red muscle fibers (HP:0003200) | 2.25281120 |
| 69 | Abnormality of reticulocytes (HP:0004312) | 2.24042711 |
| 70 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.21566846 |
| 71 | Spastic diplegia (HP:0001264) | 2.19142013 |
| 72 | Mitochondrial inheritance (HP:0001427) | 2.18723903 |
| 73 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.18446221 |
| 74 | Abnormality of alanine metabolism (HP:0010916) | 2.18446221 |
| 75 | Hyperalaninemia (HP:0003348) | 2.18446221 |
| 76 | Bone marrow hypocellularity (HP:0005528) | 2.17843567 |
| 77 | Cellular immunodeficiency (HP:0005374) | 2.17822020 |
| 78 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.17736067 |
| 79 | Unilateral renal agenesis (HP:0000122) | 2.17328611 |
| 80 | Basal cell carcinoma (HP:0002671) | 2.17213641 |
| 81 | Progressive external ophthalmoplegia (HP:0000590) | 2.14350284 |
| 82 | Lactic acidosis (HP:0003128) | 2.13831440 |
| 83 | Unsteady gait (HP:0002317) | 2.12004154 |
| 84 | Cerebral edema (HP:0002181) | 2.11170771 |
| 85 | Abnormality of the umbilical cord (HP:0010881) | 2.11024267 |
| 86 | Acute necrotizing encephalopathy (HP:0006965) | 2.10666446 |
| 87 | Squamous cell carcinoma (HP:0002860) | 2.10387400 |
| 88 | Adenoma sebaceum (HP:0009720) | 2.10032133 |
| 89 | Angiofibromas (HP:0010615) | 2.10032133 |
| 90 | Pancytopenia (HP:0001876) | 2.10009765 |
| 91 | Type I transferrin isoform profile (HP:0003642) | 2.09524811 |
| 92 | Hypoplasia of the pons (HP:0012110) | 2.06977026 |
| 93 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.05392933 |
| 94 | Tongue fasciculations (HP:0001308) | 2.04558705 |
| 95 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.04230053 |
| 96 | Facial cleft (HP:0002006) | 2.03900263 |
| 97 | Horseshoe kidney (HP:0000085) | 2.03888056 |
| 98 | Rhabdomyolysis (HP:0003201) | 2.02349435 |
| 99 | Absent radius (HP:0003974) | 2.01248744 |
| 100 | Increased nuchal translucency (HP:0010880) | 2.00460805 |
| 101 | Increased hepatocellular lipid droplets (HP:0006565) | 2.00209057 |
| 102 | Lipid accumulation in hepatocytes (HP:0006561) | 1.99307696 |
| 103 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.98636302 |
| 104 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.96380874 |
| 105 | Renal Fanconi syndrome (HP:0001994) | 1.96020808 |
| 106 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.95925757 |
| 107 | Acute encephalopathy (HP:0006846) | 1.95816808 |
| 108 | Increased intramyocellular lipid droplets (HP:0012240) | 1.95801087 |
| 109 | Abnormality of the pons (HP:0007361) | 1.92790536 |
| 110 | Duodenal stenosis (HP:0100867) | 1.91938820 |
| 111 | Small intestinal stenosis (HP:0012848) | 1.91938820 |
| 112 | Entropion (HP:0000621) | 1.91749722 |
| 113 | Progressive macrocephaly (HP:0004481) | 1.91741528 |
| 114 | Exercise intolerance (HP:0003546) | 1.89881174 |
| 115 | Gout (HP:0001997) | 1.89146621 |
| 116 | Poikiloderma (HP:0001029) | 1.89060659 |
| 117 | Slender long bone (HP:0003100) | 1.88321112 |
| 118 | Reduced antithrombin III activity (HP:0001976) | 1.88301007 |
| 119 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.88208603 |
| 120 | Cafe-au-lait spot (HP:0000957) | 1.87724442 |
| 121 | Abnormal trabecular bone morphology (HP:0100671) | 1.87087337 |
| 122 | Personality changes (HP:0000751) | 1.86767836 |
| 123 | Sloping forehead (HP:0000340) | 1.86648236 |
| 124 | Pelvic girdle muscle weakness (HP:0003749) | 1.86305206 |
| 125 | Increased muscle lipid content (HP:0009058) | 1.86197732 |
| 126 | Muscle fibrillation (HP:0010546) | 1.85817892 |
| 127 | Hyperacusis (HP:0010780) | 1.85646475 |
| 128 | Microglossia (HP:0000171) | 1.84124884 |
| 129 | Hypoplastic left heart (HP:0004383) | 1.83714406 |
| 130 | Absent forearm bone (HP:0003953) | 1.83143849 |
| 131 | Aplasia involving forearm bones (HP:0009822) | 1.83143849 |
| 132 | Glossoptosis (HP:0000162) | 1.79153113 |
| 133 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.76153576 |
| 134 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.76153576 |
| 135 | Abnormal protein glycosylation (HP:0012346) | 1.76153576 |
| 136 | Abnormal glycosylation (HP:0012345) | 1.76153576 |
| 137 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.74961904 |
| 138 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.73183440 |
| 139 | Single umbilical artery (HP:0001195) | 1.73183440 |
| 140 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.73183440 |
| 141 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.71478727 |
| 142 | Chronic bronchitis (HP:0004469) | 1.70956449 |
| 143 | Death in infancy (HP:0001522) | 1.70310143 |
| 144 | Diaphragmatic weakness (HP:0009113) | 1.68991478 |
| 145 | Abnormality of the carotid arteries (HP:0005344) | 1.68237556 |
| 146 | Dysphonia (HP:0001618) | 1.67540360 |
| 147 | Hand muscle atrophy (HP:0009130) | 1.66428286 |
| 148 | Fasciculations (HP:0002380) | 1.66358911 |
| 149 | Hypoplasia of the uterus (HP:0000013) | 1.63886503 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.81747993 |
| 2 | VRK2 | 4.23742238 |
| 3 | WEE1 | 4.18579188 |
| 4 | CDC7 | 3.93362652 |
| 5 | PBK | 3.56887518 |
| 6 | SMG1 | 3.44928200 |
| 7 | EIF2AK1 | 3.44659728 |
| 8 | TSSK6 | 3.09822653 |
| 9 | NEK1 | 2.85576459 |
| 10 | NME2 | 2.68075917 |
| 11 | TESK2 | 2.46639392 |
| 12 | NEK2 | 2.32606103 |
| 13 | SCYL2 | 2.31164475 |
| 14 | STK16 | 2.24602258 |
| 15 | TTK | 2.22595923 |
| 16 | ACVR1B | 2.07330970 |
| 17 | RPS6KB2 | 1.92383270 |
| 18 | EEF2K | 1.91100850 |
| 19 | PLK4 | 1.82120405 |
| 20 | VRK1 | 1.80572385 |
| 21 | SRPK1 | 1.79521400 |
| 22 | EIF2AK3 | 1.78769262 |
| 23 | PLK1 | 1.78125446 |
| 24 | BRSK2 | 1.72736746 |
| 25 | IRAK3 | 1.61380749 |
| 26 | MST4 | 1.55185486 |
| 27 | MAPKAPK3 | 1.51562666 |
| 28 | TLK1 | 1.50644241 |
| 29 | CDK7 | 1.49419842 |
| 30 | MAP3K8 | 1.45701347 |
| 31 | CCNB1 | 1.43508300 |
| 32 | BCKDK | 1.43430876 |
| 33 | AURKA | 1.39414667 |
| 34 | AURKB | 1.39213719 |
| 35 | TAF1 | 1.37870974 |
| 36 | BRAF | 1.35742449 |
| 37 | MAP3K11 | 1.33642659 |
| 38 | PASK | 1.33089594 |
| 39 | ATR | 1.31340501 |
| 40 | BRSK1 | 1.27173025 |
| 41 | MAP3K12 | 1.27052320 |
| 42 | PAK4 | 1.26760259 |
| 43 | PKN2 | 1.19175561 |
| 44 | KDR | 1.17316891 |
| 45 | DYRK3 | 1.17246791 |
| 46 | PLK3 | 1.10299126 |
| 47 | MST1R | 1.09263087 |
| 48 | PDK2 | 1.08298040 |
| 49 | CHEK2 | 1.07738091 |
| 50 | RPS6KA4 | 1.06927790 |
| 51 | EPHA2 | 1.06701190 |
| 52 | CDK4 | 1.05755952 |
| 53 | LATS2 | 1.05254929 |
| 54 | TGFBR1 | 1.00344156 |
| 55 | MAP2K3 | 0.99770551 |
| 56 | PIM2 | 0.99546182 |
| 57 | FLT3 | 0.98232629 |
| 58 | ICK | 0.97464585 |
| 59 | CHEK1 | 0.92839685 |
| 60 | LRRK2 | 0.91735154 |
| 61 | STK10 | 0.91710551 |
| 62 | ARAF | 0.90984387 |
| 63 | PAK1 | 0.89806113 |
| 64 | RAF1 | 0.89694897 |
| 65 | TESK1 | 0.86025988 |
| 66 | CDK8 | 0.83969250 |
| 67 | DAPK1 | 0.77742061 |
| 68 | CDK19 | 0.75414771 |
| 69 | ILK | 0.74315160 |
| 70 | TRIB3 | 0.71535295 |
| 71 | EIF2AK2 | 0.71486951 |
| 72 | CSNK2A2 | 0.71076173 |
| 73 | MAPKAPK5 | 0.69624427 |
| 74 | NME1 | 0.68401595 |
| 75 | CDK9 | 0.67387064 |
| 76 | PDK4 | 0.67359979 |
| 77 | PDK3 | 0.67359979 |
| 78 | CDK2 | 0.66543074 |
| 79 | NUAK1 | 0.66421686 |
| 80 | MAP3K9 | 0.66387795 |
| 81 | PRKD3 | 0.66057817 |
| 82 | MAP4K1 | 0.63682038 |
| 83 | MKNK1 | 0.63258540 |
| 84 | CSNK1A1L | 0.62830000 |
| 85 | MAP3K10 | 0.61627354 |
| 86 | ALK | 0.61479075 |
| 87 | CSNK2A1 | 0.61363448 |
| 88 | CDK12 | 0.57253001 |
| 89 | ERBB4 | 0.57157996 |
| 90 | CSNK1G1 | 0.55955831 |
| 91 | ATM | 0.54828784 |
| 92 | PIM1 | 0.53866738 |
| 93 | MET | 0.53277669 |
| 94 | PRKCI | 0.52937560 |
| 95 | TRIM28 | 0.52617375 |
| 96 | STK4 | 0.52275842 |
| 97 | LIMK1 | 0.49960250 |
| 98 | GRK6 | 0.49530554 |
| 99 | ABL2 | 0.47730905 |
| 100 | MAP3K6 | 0.46561531 |
| 101 | MOS | 0.46512282 |
| 102 | CAMK2G | 0.46033486 |
| 103 | KSR2 | 0.45530434 |
| 104 | TAOK1 | 0.43605932 |
| 105 | CDK1 | 0.40103532 |
| 106 | CSNK1G2 | 0.39157219 |
| 107 | ZAP70 | 0.36780871 |
| 108 | CSNK1E | 0.36195257 |
| 109 | NEK6 | 0.32944161 |
| 110 | PTK2 | 0.32383658 |
| 111 | ZAK | 0.32301188 |
| 112 | MAP2K2 | 0.31201344 |
| 113 | PNCK | 0.30839009 |
| 114 | DYRK2 | 0.29482022 |
| 115 | STK38L | 0.29178023 |
| 116 | MAPK11 | 0.29175504 |
| 117 | AKT2 | 0.28978103 |
| 118 | CDK11A | 0.28702434 |
| 119 | CDK15 | 0.25456731 |
| 120 | RPS6KA5 | 0.25289654 |
| 121 | CSNK1G3 | 0.25136770 |
| 122 | CDK18 | 0.24542184 |
| 123 | DAPK3 | 0.23928233 |
| 124 | TAOK2 | 0.21505102 |
| 125 | CDK14 | 0.21310542 |
| 126 | TTN | 0.20827222 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.93903686 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.12305688 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 3.92206645 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.51338170 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.46073336 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.13573196 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 3.01768418 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 2.92927737 |
| 9 | Base excision repair_Homo sapiens_hsa03410 | 2.91952700 |
| 10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.82892373 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.75736736 |
| 12 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.63599661 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 2.56577068 |
| 14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.51384087 |
| 15 | Cell cycle_Homo sapiens_hsa04110 | 2.31313004 |
| 16 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.82223964 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 1.76678643 |
| 18 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.76267133 |
| 19 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.76004874 |
| 20 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.71513283 |
| 21 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.58020528 |
| 22 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.54595996 |
| 23 | Basal transcription factors_Homo sapiens_hsa03022 | 1.48219870 |
| 24 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.43368902 |
| 25 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.42293267 |
| 26 | Carbon metabolism_Homo sapiens_hsa01200 | 1.37208102 |
| 27 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.35504502 |
| 28 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.26744444 |
| 29 | Purine metabolism_Homo sapiens_hsa00230 | 1.26479445 |
| 30 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.22296395 |
| 31 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.21614268 |
| 32 | Sulfur relay system_Homo sapiens_hsa04122 | 1.17126252 |
| 33 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.16968665 |
| 34 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.10774219 |
| 35 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.08659720 |
| 36 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.07906069 |
| 37 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.01795571 |
| 38 | Parkinsons disease_Homo sapiens_hsa05012 | 1.01551775 |
| 39 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.00118161 |
| 40 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.98528106 |
| 41 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.96709853 |
| 42 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.94575744 |
| 43 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.92371835 |
| 44 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.91488436 |
| 45 | Huntingtons disease_Homo sapiens_hsa05016 | 0.90484056 |
| 46 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.90434623 |
| 47 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.85457270 |
| 48 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.84392216 |
| 49 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.83948853 |
| 50 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.83669562 |
| 51 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.82834682 |
| 52 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.82351888 |
| 53 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.80881153 |
| 54 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.76033806 |
| 55 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.71468575 |
| 56 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.71154675 |
| 57 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.70168356 |
| 58 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.69433654 |
| 59 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.68890134 |
| 60 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.63874334 |
| 61 | Galactose metabolism_Homo sapiens_hsa00052 | 0.61463100 |
| 62 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.60639124 |
| 63 | Protein export_Homo sapiens_hsa03060 | 0.60334891 |
| 64 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.55244062 |
| 65 | Thyroid cancer_Homo sapiens_hsa05216 | 0.55120834 |
| 66 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.45946872 |
| 67 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.45048843 |
| 68 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.44274538 |
| 69 | Metabolic pathways_Homo sapiens_hsa01100 | 0.44088031 |
| 70 | Legionellosis_Homo sapiens_hsa05134 | 0.41095532 |
| 71 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.40988611 |
| 72 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.39266403 |
| 73 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.36440968 |
| 74 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.35588106 |
| 75 | HTLV-I infection_Homo sapiens_hsa05166 | 0.33579237 |
| 76 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.32647651 |
| 77 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.31256381 |
| 78 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.29852222 |
| 79 | Shigellosis_Homo sapiens_hsa05131 | 0.28799730 |
| 80 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.28186546 |
| 81 | Prion diseases_Homo sapiens_hsa05020 | 0.28172115 |
| 82 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.26333551 |
| 83 | Alzheimers disease_Homo sapiens_hsa05010 | 0.26166143 |
| 84 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.25243417 |
| 85 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.23426939 |
| 86 | Bladder cancer_Homo sapiens_hsa05219 | 0.22322961 |
| 87 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.21197921 |
| 88 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.21145193 |
| 89 | Alcoholism_Homo sapiens_hsa05034 | 0.20283128 |
| 90 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.20051806 |
| 91 | Apoptosis_Homo sapiens_hsa04210 | 0.19541358 |
| 92 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.17358008 |
| 93 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.13825289 |
| 94 | Lysine degradation_Homo sapiens_hsa00310 | 0.13072931 |
| 95 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.12742317 |
| 96 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.12634855 |
| 97 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.12597985 |
| 98 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.10904282 |
| 99 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.10857332 |
| 100 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.09868292 |
| 101 | Tight junction_Homo sapiens_hsa04530 | 0.09787806 |
| 102 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.09612840 |
| 103 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.08348255 |
| 104 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.08137589 |
| 105 | Colorectal cancer_Homo sapiens_hsa05210 | 0.07979724 |
| 106 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.07586688 |
| 107 | Peroxisome_Homo sapiens_hsa04146 | 0.05097446 |
| 108 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.05044335 |
| 109 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.03794801 |
| 110 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.02635240 |
| 111 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.02254705 |
| 112 | Hepatitis B_Homo sapiens_hsa05161 | 0.01808357 |
| 113 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.01540849 |
| 114 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.01103900 |
| 115 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.00486695 |
| 116 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | -0.0350509 |
| 117 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | -0.0287249 |
| 118 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | -0.0170832 |
| 119 | mTOR signaling pathway_Homo sapiens_hsa04150 | -0.0088014 |

