AHSG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.51620348
2L-phenylalanine catabolic process (GO:0006559)7.51620348
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.20451895
4L-phenylalanine metabolic process (GO:0006558)7.20451895
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.81633827
6aromatic amino acid family catabolic process (GO:0009074)6.59290934
7intestinal cholesterol absorption (GO:0030299)6.57437910
8negative regulation of fibrinolysis (GO:0051918)6.14170785
9high-density lipoprotein particle remodeling (GO:0034375)6.13881334
10glyoxylate metabolic process (GO:0046487)5.91999141
11regulation of fibrinolysis (GO:0051917)5.86532317
12regulation of apoptotic cell clearance (GO:2000425)5.81503811
13indolalkylamine catabolic process (GO:0046218)5.79521307
14tryptophan catabolic process (GO:0006569)5.79521307
15indole-containing compound catabolic process (GO:0042436)5.79521307
16kynurenine metabolic process (GO:0070189)5.77997065
17urea metabolic process (GO:0019627)5.65535336
18urea cycle (GO:0000050)5.65535336
19bile acid biosynthetic process (GO:0006699)5.64465571
20protein carboxylation (GO:0018214)5.50018178
21peptidyl-glutamic acid carboxylation (GO:0017187)5.50018178
22tryptophan metabolic process (GO:0006568)5.47199831
23reverse cholesterol transport (GO:0043691)5.46214676
24regulation of cholesterol esterification (GO:0010872)5.45177647
25alpha-linolenic acid metabolic process (GO:0036109)5.42832999
26sulfur amino acid catabolic process (GO:0000098)5.39109324
27cysteine metabolic process (GO:0006534)5.37606784
28protein-lipid complex remodeling (GO:0034368)5.27960278
29macromolecular complex remodeling (GO:0034367)5.27960278
30plasma lipoprotein particle remodeling (GO:0034369)5.27960278
31regulation of protein activation cascade (GO:2000257)5.23844321
32nitrogen cycle metabolic process (GO:0071941)5.19041538
33complement activation, alternative pathway (GO:0006957)5.12614291
34serine family amino acid catabolic process (GO:0009071)5.12031598
35regulation of triglyceride catabolic process (GO:0010896)5.01655452
36phospholipid efflux (GO:0033700)4.98692284
37bile acid metabolic process (GO:0008206)4.90725108
38plasma lipoprotein particle clearance (GO:0034381)4.83724080
39tyrosine metabolic process (GO:0006570)4.81471769
40regulation of complement activation (GO:0030449)4.80861188
41triglyceride homeostasis (GO:0070328)4.79591447
42acylglycerol homeostasis (GO:0055090)4.79591447
43aromatic amino acid family metabolic process (GO:0009072)4.79222959
44homocysteine metabolic process (GO:0050667)4.70247329
45negative regulation of cholesterol transport (GO:0032375)4.69691266
46negative regulation of sterol transport (GO:0032372)4.69691266
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.64212212
48amino-acid betaine metabolic process (GO:0006577)4.61257767
49cholesterol efflux (GO:0033344)4.59714254
50cellular ketone body metabolic process (GO:0046950)4.58894859
51alpha-amino acid catabolic process (GO:1901606)4.54430177
52proline metabolic process (GO:0006560)4.52555946
53plasma lipoprotein particle assembly (GO:0034377)4.41486305
54glycine metabolic process (GO:0006544)4.35111321
55lysine metabolic process (GO:0006553)4.34244536
56lysine catabolic process (GO:0006554)4.34244536
57low-density lipoprotein particle remodeling (GO:0034374)4.30866668
58intestinal absorption (GO:0050892)4.30363178
59positive regulation of blood coagulation (GO:0030194)4.29575116
60positive regulation of hemostasis (GO:1900048)4.29575116
61fibrinolysis (GO:0042730)4.28792393
62imidazole-containing compound metabolic process (GO:0052803)4.24431809
63bile acid and bile salt transport (GO:0015721)4.22379983
64negative regulation of blood coagulation (GO:0030195)4.22007068
65negative regulation of hemostasis (GO:1900047)4.22007068
66glutamate metabolic process (GO:0006536)4.21932977
67blood coagulation, intrinsic pathway (GO:0007597)4.20684389
68regulation of cholesterol biosynthetic process (GO:0045540)4.18134206
69cellular amino acid catabolic process (GO:0009063)4.18118079
70cholesterol transport (GO:0030301)4.13278575
71sterol transport (GO:0015918)4.13278575
72regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.13045897
73positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.11579776
74indolalkylamine metabolic process (GO:0006586)4.10509101
75positive regulation of triglyceride lipase activity (GO:0061365)4.09096318
76positive regulation of lipoprotein lipase activity (GO:0051006)4.09096318
77aldehyde catabolic process (GO:0046185)4.08494714
78serine family amino acid metabolic process (GO:0009069)4.08221873
79arginine metabolic process (GO:0006525)4.06189371
80coenzyme catabolic process (GO:0009109)4.04350332
81positive regulation of fatty acid biosynthetic process (GO:0045723)4.04298079
82cellular modified amino acid catabolic process (GO:0042219)4.03232416
83plasma lipoprotein particle organization (GO:0071827)4.02324162
84cellular biogenic amine catabolic process (GO:0042402)4.01963485
85amine catabolic process (GO:0009310)4.01963485
86serine family amino acid biosynthetic process (GO:0009070)4.01244512
87regulation of humoral immune response (GO:0002920)4.00543788
88negative regulation of lipase activity (GO:0060192)3.99535211
89dicarboxylic acid biosynthetic process (GO:0043650)3.98267560
90ketone body metabolic process (GO:1902224)3.97065481
91benzene-containing compound metabolic process (GO:0042537)3.96261678
92protein-lipid complex assembly (GO:0065005)3.95421288
93cellular glucuronidation (GO:0052695)3.94634303
94phospholipid homeostasis (GO:0055091)3.92698340
95positive regulation of lipid catabolic process (GO:0050996)3.90405033
96positive regulation of coagulation (GO:0050820)3.89977787
97cholesterol homeostasis (GO:0042632)3.89013794
98positive regulation of steroid metabolic process (GO:0045940)3.88461474
99negative regulation of coagulation (GO:0050819)3.86753214
100positive regulation of extracellular matrix organization (GO:1903055)3.86669299
101diacylglycerol metabolic process (GO:0046339)3.86357574
102negative regulation of complement activation (GO:0045916)3.83824169
103drug catabolic process (GO:0042737)3.83338818
104sterol homeostasis (GO:0055092)3.82263121
105very-low-density lipoprotein particle assembly (GO:0034379)3.81020968
106protein-lipid complex subunit organization (GO:0071825)3.78103323
107protein activation cascade (GO:0072376)3.75507190
108low-density lipoprotein particle clearance (GO:0034383)3.74660762
109cofactor catabolic process (GO:0051187)3.73202325
110ethanol oxidation (GO:0006069)3.69319483
111regulation of plasminogen activation (GO:0010755)3.67705547
112heme transport (GO:0015886)3.67629147
113lipoprotein metabolic process (GO:0042157)3.67031853
114organic acid catabolic process (GO:0016054)3.66454412
115carboxylic acid catabolic process (GO:0046395)3.66454412
116negative regulation of wound healing (GO:0061045)3.65740771
117negative regulation of protein activation cascade (GO:2000258)3.62255337
118complement activation (GO:0006956)3.59768605
119complement activation, classical pathway (GO:0006958)3.57867217
120opsonization (GO:0008228)3.56611807
121regulation of bile acid biosynthetic process (GO:0070857)3.53855611
122* acute-phase response (GO:0006953)3.53352621
123regulation of cholesterol homeostasis (GO:2000188)3.53319382
124proline biosynthetic process (GO:0006561)3.38966697
125lipid homeostasis (GO:0055088)3.37578648
126peptidyl-glutamic acid modification (GO:0018200)3.36252081
127lung epithelium development (GO:0060428)3.35628570
128embryonic retina morphogenesis in camera-type eye (GO:0060059)3.28443258
129regulation of cholesterol metabolic process (GO:0090181)3.27313049
130neutral lipid catabolic process (GO:0046461)3.21590517
131acylglycerol catabolic process (GO:0046464)3.21590517
132renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.21335221
133negative regulation of lipid transport (GO:0032369)3.21101045
134cytolysis (GO:0019835)3.11208175
135epoxygenase P450 pathway (GO:0019373)3.10802295
136regulation of extracellular matrix organization (GO:1903053)3.09109294
137negative regulation of sodium ion transport (GO:0010766)3.08166640
138regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.07728490
139regulation of fatty acid biosynthetic process (GO:0042304)3.07623544
140positive regulation of hormone metabolic process (GO:0032352)3.05100184
141ethanol metabolic process (GO:0006067)3.02213301
142glutamine family amino acid biosynthetic process (GO:0009084)3.00468044

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.39874255
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.18706945
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.84134448
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.49244881
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.32835858
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.16523041
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.98397975
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.03997695
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.96002011
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.58360182
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09738092
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.1458267
13HIF1A_21447827_ChIP-Seq_MCF-7_Human1.99643302
14* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97994793
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91008963
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85272298
17TP63_17297297_ChIP-ChIP_HaCaT_Human1.72795663
18* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62801912
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61439815
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57255046
21CLOCK_20551151_ChIP-Seq_293T_Human1.54825407
22GATA1_22025678_ChIP-Seq_K562_Human1.53019014
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50579827
24HTT_18923047_ChIP-ChIP_STHdh_Human1.49610188
25AR_21909140_ChIP-Seq_LNCAP_Human1.46001496
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.43200298
27* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40032368
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34758397
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24504675
30GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.22327734
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19402227
32* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16985887
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15261974
34POU5F1_16518401_ChIP-PET_MESCs_Mouse1.06250534
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.05130879
36NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02928853
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00082255
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99051665
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96083424
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94452871
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93343887
42DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89993299
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89192133
44SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88133527
45IRF8_22096565_ChIP-ChIP_GC-B_Human0.85167011
46CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85013974
47RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84648415
48AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83561171
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83207851
50TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83045355
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82951559
52ZNF263_19887448_ChIP-Seq_K562_Human0.82637498
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82410595
54RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81990547
55RACK7_27058665_Chip-Seq_MCF-7_Human0.81880136
56NANOG_21062744_ChIP-ChIP_HESCs_Human0.80766462
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80024362
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79809283
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79491623
60SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79316124
61ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78658403
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78122774
63SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77658021
64* GATA4_25053715_ChIP-Seq_YYC3_Human0.76355887
65SMC4_20622854_ChIP-Seq_HELA_Human0.76276915
66RARA_24833708_ChIP-Seq_LIVER_Mouse0.75783489
67TP53_22127205_ChIP-Seq_IMR90_Human0.75669719
68NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.74109197
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72908273
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.71881450
71SOX11_22085726_ChIP-Seq_ESNs_Mouse0.71235465
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.71124313
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.70651224
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.70254203
75KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70186555
76SOX17_20123909_ChIP-Seq_XEN_Mouse0.69253739
77AR_21572438_ChIP-Seq_LNCaP_Human0.69235933
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68514604
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.67847909
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67136072
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67028575
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.66820068
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66582877
84P68_20966046_ChIP-Seq_HELA_Human0.65539660
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65395820
86CSB_26484114_Chip-Seq_FIBROBLAST_Human0.64525400
87SOX2_20726797_ChIP-Seq_SW620_Human0.64204214
88RAC3_21632823_ChIP-Seq_H3396_Human0.64092527
89ESR2_21235772_ChIP-Seq_MCF-7_Human0.64035408
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63459656
91SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63225825
92RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63171560
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62739237
94RARB_24833708_ChIP-Seq_LIVER_Mouse0.62730492
95LXR_22292898_ChIP-Seq_THP-1_Human0.62549225
96ATF3_27146783_Chip-Seq_COLON_Human0.61914248
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61599905
98GATA1_19941826_ChIP-Seq_K562_Human0.57441423
99NRF2_20460467_ChIP-Seq_MEFs_Mouse0.57175037
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.57175037
101KAP1_27257070_Chip-Seq_ESCs_Mouse0.56912026
102CEBPB_22108803_ChIP-Seq_LS180_Human0.56562178
103EGR1_19032775_ChIP-ChIP_M12_Human0.56353540
104GATA1_19941827_ChIP-Seq_MEL_Mouse0.54213934
105FOXA1_25552417_ChIP-Seq_VCAP_Human0.51585337
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51173990
107AR_20517297_ChIP-Seq_VCAP_Human0.51123878
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50996537
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.49368961
110* MYC_19915707_ChIP-ChIP_AK7_Human0.49248362
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49086347
112GATA2_19941826_ChIP-Seq_K562_Human0.48155294
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.47910330
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.47809128
115P53_21459846_ChIP-Seq_SAOS-2_Human0.47344778
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46788425
117TAF2_19829295_ChIP-Seq_ESCs_Human0.45105665
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44617888
119ESET_19884257_ChIP-Seq_ESCs_Mouse0.44380817
120CBP_21632823_ChIP-Seq_H3396_Human0.44090224
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.43365148
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43165910
123PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42641316
124STAT1_17558387_ChIP-Seq_HELA_Human0.42157064
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.40552960
126PPAR_26484153_Chip-Seq_NCI-H1993_Human0.40092006
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.38573505
128GATA6_25053715_ChIP-Seq_YYC3_Human0.38158701
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.37666597
130* MYC_27129775_Chip-Seq_CORNEA_Mouse0.37515555
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.36671777
132STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36523645
133SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.35986899
134SPI1_26923725_Chip-Seq_HPCs_Mouse0.35663153
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.35537050
136BCOR_27268052_Chip-Seq_Bcells_Human0.35176250
137LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35151588
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.35115260
139OCT4_20526341_ChIP-Seq_ESCs_Human0.34121378
140SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.34100115
141BCAT_22108803_ChIP-Seq_LS180_Human0.33542565
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33535621
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.33381574
144EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.33321674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.12614905
2MP0005360_urolithiasis7.54047829
3MP0005085_abnormal_gallbladder_physiolo6.30796594
4MP0005365_abnormal_bile_salt6.08951653
5MP0008875_abnormal_xenobiotic_pharmacok5.02786150
6MP0003122_maternal_imprinting4.83630887
7MP0003806_abnormal_nucleotide_metabolis4.03891523
8MP0003252_abnormal_bile_duct3.77613757
9MP0010329_abnormal_lipoprotein_level3.71435196
10MP0009840_abnormal_foam_cell3.59863016
11MP0005083_abnormal_biliary_tract3.21124673
12MP0003195_calcinosis2.93036088
13MP0003191_abnormal_cellular_cholesterol2.77851364
14MP0005332_abnormal_amino_acid2.76490752
15MP0003123_paternal_imprinting2.74448518
16MP0000566_synostosis2.70390315
17MP0001666_abnormal_nutrient_absorption2.54620479
18MP0000609_abnormal_liver_physiology2.20390678
19MP0002089_abnormal_postnatal_growth/wei2.19925934
20MP0004019_abnormal_vitamin_homeostasis2.15974297
21MP0003172_abnormal_lysosome_physiology2.15283543
22* MP0002118_abnormal_lipid_homeostasis2.07932034
23MP0002138_abnormal_hepatobiliary_system2.00439955
24MP0001915_intracranial_hemorrhage1.90701843
25MP0003868_abnormal_feces_composition1.86283208
26MP0005319_abnormal_enzyme/_coenzyme1.80767613
27MP0001764_abnormal_homeostasis1.68793646
28MP0009697_abnormal_copulation1.59525878
29MP0003011_delayed_dark_adaptation1.57887696
30MP0005584_abnormal_enzyme/coenzyme_acti1.57699444
31MP0005451_abnormal_body_composition1.54533782
32MP0003656_abnormal_erythrocyte_physiolo1.52813031
33MP0003121_genomic_imprinting1.50709160
34MP0005409_darkened_coat_color1.31964282
35MP0006054_spinal_hemorrhage1.28641068
36MP0003186_abnormal_redox_activity1.26453129
37MP0000604_amyloidosis1.26223375
38MP0009643_abnormal_urine_homeostasis1.23390615
39MP0009780_abnormal_chondrocyte_physiolo1.23295549
40MP0000598_abnormal_liver_morphology1.22173169
41MP0003705_abnormal_hypodermis_morpholog1.19945621
42MP0005257_abnormal_intraocular_pressure1.15445236
43MP0002254_reproductive_system_inflammat1.15079503
44MP0004272_abnormal_basement_membrane1.13419380
45MP0010368_abnormal_lymphatic_system1.11255530
46MP0009763_increased_sensitivity_to1.05521718
47MP0009764_decreased_sensitivity_to1.04954983
48MP0005647_abnormal_sex_gland1.03205659
49MP0003567_abnormal_fetal_cardiomyocyte1.02048491
50MP0005636_abnormal_mineral_homeostasis0.97380337
51MP0003315_abnormal_perineum_morphology0.94805886
52MP0008469_abnormal_protein_level0.91314779
53MP0003950_abnormal_plasma_membrane0.89168558
54* MP0009642_abnormal_blood_homeostasis0.89029830
55MP0002938_white_spotting0.85710504
56MP0005376_homeostasis/metabolism_phenot0.82631071
57MP0005408_hypopigmentation0.81997077
58MP0009384_cardiac_valve_regurgitation0.80009505
59MP0009765_abnormal_xenobiotic_induced0.79025947
60MP0006036_abnormal_mitochondrial_physio0.79004103
61MP0005076_abnormal_cell_differentiation0.78619663
62MP0004264_abnormal_extraembryonic_tissu0.78568923
63* MP0002078_abnormal_glucose_homeostasis0.76491753
64MP0003115_abnormal_respiratory_system0.75459683
65MP0005084_abnormal_gallbladder_morpholo0.74823142
66MP0005377_hearing/vestibular/ear_phenot0.74803062
67MP0003878_abnormal_ear_physiology0.74803062
68MP0003879_abnormal_hair_cell0.74605289
69MP0005670_abnormal_white_adipose0.74523337
70MP0002971_abnormal_brown_adipose0.72351118
71MP0009053_abnormal_anal_canal0.71838305
72MP0003942_abnormal_urinary_system0.70649174
73MP0001661_extended_life_span0.70592822
74MP0003690_abnormal_glial_cell0.70483920
75MP0005464_abnormal_platelet_physiology0.70393905
76MP0005220_abnormal_exocrine_pancreas0.69830683
77MP0002876_abnormal_thyroid_physiology0.69563831
78MP0002933_joint_inflammation0.69003271
79MP0000639_abnormal_adrenal_gland0.68855392
80MP0001270_distended_abdomen0.67520711
81MP0004130_abnormal_muscle_cell0.67318801
82MP0008438_abnormal_cutaneous_collagen0.67222896
83MP0003183_abnormal_peptide_metabolism0.66894278
84MP0003329_amyloid_beta_deposits0.66152415
85MP0005334_abnormal_fat_pad0.65780936
86MP0003632_abnormal_nervous_system0.64974354
87MP0003566_abnormal_cell_adhesion0.64547591
88MP0002909_abnormal_adrenal_gland0.63810827
89MP0001756_abnormal_urination0.62543216
90MP0005535_abnormal_body_temperature0.62497399
91MP0000920_abnormal_myelination0.62489066
92MP0000003_abnormal_adipose_tissue0.61068565
93MP0005266_abnormal_metabolism0.60246251
94MP0003943_abnormal_hepatobiliary_system0.57991155
95MP0001324_abnormal_eye_pigmentation0.57820824
96MP0008260_abnormal_autophagy0.56463059
97MP0005410_abnormal_fertilization0.53413704
98MP0005395_other_phenotype0.53104370
99MP0000858_altered_metastatic_potential0.52610822
100MP0005379_endocrine/exocrine_gland_phen0.51141099
101MP0002092_abnormal_eye_morphology0.50741431
102MP0002822_catalepsy0.50158481
103MP0006035_abnormal_mitochondrial_morpho0.49875418
104MP0004883_abnormal_blood_vessel0.49289399
105MP0003638_abnormal_response/metabolism_0.48545824
106MP0003436_decreased_susceptibility_to0.48298050
107MP0002282_abnormal_trachea_morphology0.47543125
108MP0003075_altered_response_to0.46918217
109MP0002136_abnormal_kidney_physiology0.46697307
110MP0008874_decreased_physiological_sensi0.45694370
111MP0008873_increased_physiological_sensi0.45676227
112* MP0005448_abnormal_energy_balance0.44957336
113MP0000371_diluted_coat_color0.44834271
114MP0003718_maternal_effect0.44614504
115MP0003890_abnormal_embryonic-extraembry0.43886568
116MP0002160_abnormal_reproductive_system0.43391421
117MP0002837_dystrophic_cardiac_calcinosis0.42176952
118MP0003724_increased_susceptibility_to0.41976160
119MP0003631_nervous_system_phenotype0.40927650
120MP0002928_abnormal_bile_duct0.40110411
121MP0000249_abnormal_blood_vessel0.39995821
122MP0008872_abnormal_physiological_respon0.39816188
123MP0002249_abnormal_larynx_morphology0.38838498
124* MP0003953_abnormal_hormone_level0.38177967
125MP0009672_abnormal_birth_weight0.38031936
126MP0004782_abnormal_surfactant_physiolog0.37204178
127MP0005666_abnormal_adipose_tissue0.36966221
128MP0001243_abnormal_dermal_layer0.36864705
129MP0005248_abnormal_Harderian_gland0.36643162
130MP0005164_abnormal_response_to0.36085183
131MP0005166_decreased_susceptibility_to0.36077298
132MP0009115_abnormal_fat_cell0.32873994
133MP0005167_abnormal_blood-brain_barrier0.32444939
134MP0000230_abnormal_systemic_arterial0.32229529
135MP0002168_other_aberrant_phenotype0.32013628
136MP0001845_abnormal_inflammatory_respons0.31664647
137MP0006082_CNS_inflammation0.30119894
138MP0002970_abnormal_white_adipose0.29470527
139MP0001853_heart_inflammation0.29117724
140MP0002796_impaired_skin_barrier0.28662493
141MP0002132_abnormal_respiratory_system0.27853611
142MP0000579_abnormal_nail_morphology0.26591183
143MP0001881_abnormal_mammary_gland0.26477003
144MP0005058_abnormal_lysosome_morphology0.24978159
145MP0005023_abnormal_wound_healing0.24861347
146MP0002135_abnormal_kidney_morphology0.24384161

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.66107894
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.37047307
3Intrahepatic cholestasis (HP:0001406)7.05439589
4Prolonged partial thromboplastin time (HP:0003645)6.75659254
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.59635371
6Xanthomatosis (HP:0000991)6.42180361
7Hypobetalipoproteinemia (HP:0003563)6.38557390
8Hyperlipoproteinemia (HP:0010980)5.69836433
9Joint hemorrhage (HP:0005261)5.10017094
10Hypolipoproteinemia (HP:0010981)5.05725119
11Complement deficiency (HP:0004431)4.98434058
12Abnormality of the common coagulation pathway (HP:0010990)4.73130871
13Hypoalphalipoproteinemia (HP:0003233)4.66572590
14Hyperammonemia (HP:0001987)4.60432274
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.60106804
16Abnormality of methionine metabolism (HP:0010901)4.37303637
17Epidermoid cyst (HP:0200040)4.32362546
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.24236147
19Ketosis (HP:0001946)4.22110842
20Hyperglycinemia (HP:0002154)4.19063838
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.12495635
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09428109
23Fat malabsorption (HP:0002630)3.91053125
24Abnormality of the intrinsic pathway (HP:0010989)3.84516176
25Hypoglycemic coma (HP:0001325)3.83985932
26Abnormality of pyrimidine metabolism (HP:0004353)3.81353898
27Abnormality of glycine metabolism (HP:0010895)3.73863499
28Abnormality of serine family amino acid metabolism (HP:0010894)3.73863499
29Hyperglycinuria (HP:0003108)3.72770032
30Hypercholesterolemia (HP:0003124)3.67146696
31Abnormality of complement system (HP:0005339)3.64828307
32Conjugated hyperbilirubinemia (HP:0002908)3.52926599
33Hyperbilirubinemia (HP:0002904)3.42193812
34Small epiphyses (HP:0010585)3.39180143
35Spontaneous abortion (HP:0005268)3.38235243
36Abnormality of carpal bone ossification (HP:0006257)3.29775912
37Abnormality of fatty-acid metabolism (HP:0004359)3.25444054
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.24380058
39Broad alveolar ridges (HP:0000187)3.15820205
40Purpura (HP:0000979)3.13785384
41Hypochromic microcytic anemia (HP:0004840)3.13274130
42Hepatocellular carcinoma (HP:0001402)3.12204378
43Abnormality of nucleobase metabolism (HP:0010932)3.03609188
44Delayed CNS myelination (HP:0002188)2.99663426
45Abnormality of serum amino acid levels (HP:0003112)2.93989937
46Ketoacidosis (HP:0001993)2.87466729
47Steatorrhea (HP:0002570)2.85762005
48Pancreatic islet-cell hyperplasia (HP:0004510)2.82089999
49Myocardial infarction (HP:0001658)2.81956990
50Abnormal tarsal ossification (HP:0008369)2.80412498
51Metabolic acidosis (HP:0001942)2.77850087
52Acanthocytosis (HP:0001927)2.76020118
53Flat acetabular roof (HP:0003180)2.69618910
54Amyloidosis (HP:0011034)2.69467459
55Glomerulonephritis (HP:0000099)2.68737832
56Skin nodule (HP:0200036)2.68259066
57Abnormality of purine metabolism (HP:0004352)2.64736833
58Broad palm (HP:0001169)2.62438706
59Asymmetry of the thorax (HP:0001555)2.61897769
60Systemic lupus erythematosus (HP:0002725)2.60069009
61Vascular calcification (HP:0004934)2.59237161
62Lethargy (HP:0001254)2.55936322
63Gingival bleeding (HP:0000225)2.53913176
64Abnormal gallbladder morphology (HP:0012437)2.52470762
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52447004
66Dicarboxylic aciduria (HP:0003215)2.52447004
67Gout (HP:0001997)2.50100772
68Cholelithiasis (HP:0001081)2.47849446
69Hepatoblastoma (HP:0002884)2.46194963
70Abnormal ossification of hand bones (HP:0005921)2.44062562
71Hypoglycemic seizures (HP:0002173)2.43963469
72Vaginal fistula (HP:0004320)2.43729461
73Cerebral edema (HP:0002181)2.42257675
74Abnormal hand bone ossification (HP:0010660)2.41718860
75Cholecystitis (HP:0001082)2.39436435
76Abnormal gallbladder physiology (HP:0012438)2.39436435
77Menorrhagia (HP:0000132)2.39058274
78Epiphyseal dysplasia (HP:0002656)2.37997824
79Spastic diplegia (HP:0001264)2.36767132
80Mitral stenosis (HP:0001718)2.36275541
81Irritability (HP:0000737)2.35585527
82Increased serum pyruvate (HP:0003542)2.35368216
83Hypoplasia of the capital femoral epiphysis (HP:0003090)2.33316387
84Esophageal varix (HP:0002040)2.32777307
85Cardiovascular calcification (HP:0011915)2.30318433
86Thrombophlebitis (HP:0004418)2.30271096
87Abnormality of glycolysis (HP:0004366)2.29405193
88Neonatal onset (HP:0003623)2.26858718
89Abnormality of the lumbar spine (HP:0100712)2.26655954
90Poikilocytosis (HP:0004447)2.25410042
91Arthropathy (HP:0003040)2.24291588
92Malnutrition (HP:0004395)2.21400373
93Diastasis recti (HP:0001540)2.19882426
94Pancreatitis (HP:0001733)2.17726818
95Abnormality of the nasal septum (HP:0000419)2.16364898
96Enlarged kidneys (HP:0000105)2.16259548
97Osteomalacia (HP:0002749)2.14545987
98Potter facies (HP:0002009)2.14373435
99Facial shape deformation (HP:0011334)2.14373435
100Alacrima (HP:0000522)2.13801301
101Recurrent gram-negative bacterial infections (HP:0005420)2.10770134
102Flared iliac wings (HP:0002869)2.07219644
103Late onset (HP:0003584)2.06825549
104Protrusio acetabuli (HP:0003179)2.06162211
105Hemorrhage of the eye (HP:0011885)2.05478646
106Vomiting (HP:0002013)2.05126583
107Brushfield spots (HP:0001088)2.03736034
108Abnormality of iron homeostasis (HP:0011031)2.01758515
109Abnormality of the gallbladder (HP:0005264)2.01486710
110Generalized aminoaciduria (HP:0002909)2.01048676
111Abnormality of the Achilles tendon (HP:0005109)2.00904658
112Sensorimotor neuropathy (HP:0007141)2.00665319
113Hyperinsulinemic hypoglycemia (HP:0000825)1.96797561
114Opisthotonus (HP:0002179)1.95520186
115Abnormality of transition element cation homeostasis (HP:0011030)1.95465022
116Irregular epiphyses (HP:0010582)1.95379000
117Abnormality of pain sensation (HP:0010832)1.89526224
118Impaired pain sensation (HP:0007328)1.89526224
119Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89213374
120Absent epiphyses (HP:0010577)1.89213374
121Nephritis (HP:0000123)1.88737030
122Rickets (HP:0002748)1.88028742
123Abnormality of the wing of the ilium (HP:0011867)1.85137606
124Neonatal death (HP:0003811)1.84487260
125Hypophosphatemic rickets (HP:0004912)1.84235719
126Pulmonary embolism (HP:0002204)1.82710977
127Reticulocytosis (HP:0001923)1.82257178
128Bifid scrotum (HP:0000048)1.82071943
129Elevated hepatic transaminases (HP:0002910)1.81083817
130Abnormality of the acetabulum (HP:0003170)1.80589872
131Alkalosis (HP:0001948)1.80392985
132Abnormal cartilage morphology (HP:0002763)1.79982218
133Abnormality of proline metabolism (HP:0010907)1.78632691
134Hydroxyprolinuria (HP:0003080)1.78632691
135Hypertriglyceridemia (HP:0002155)1.75715831
136Abnormal foot bone ossification (HP:0010675)1.74575481
137Widely patent fontanelles and sutures (HP:0004492)1.73891143
138Abnormality of endocrine pancreas physiology (HP:0012093)1.73624556
139Abnormality of the pancreatic islet cells (HP:0006476)1.73624556
140Renal cortical cysts (HP:0000803)1.73169293
141Abnormal enzyme/coenzyme activity (HP:0012379)1.72111760
142Abnormal delivery (HP:0001787)1.70225009
143Submucous cleft hard palate (HP:0000176)1.65040194
144Limited elbow extension (HP:0001377)1.64448531
145Pigmentary retinal degeneration (HP:0001146)1.64122470
146Renal duplication (HP:0000075)1.61604242
147Cupped ribs (HP:0000887)1.60601856

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.40470732
2FGFR44.70220477
3SIK14.45323050
4ERN14.36811247
5WNK43.75633021
6CDK122.97537601
7TAOK32.93826476
8TYRO32.90543703
9INSRR2.82468375
10ERBB42.54929380
11PKN22.41293325
12MAP2K42.35306320
13PDGFRA2.24969113
14FGFR12.17425695
15TRIB32.15440674
16MST1R2.14843855
17FLT31.94838582
18PIK3CA1.94612879
19MAPK111.91883817
20EEF2K1.81181099
21TYK21.80815192
22WNK11.80128864
23DAPK21.79099893
24PIK3CG1.70456434
25SIK21.63257553
26PTK61.59578249
27AKT31.57546438
28KDR1.52997745
29LATS11.44658240
30ABL21.43067757
31EIF2AK11.37862831
32NEK91.33465480
33DDR21.29554116
34JAK21.22588922
35MAP3K21.21867628
36FGFR21.20883640
37GRK61.20560002
38MAP2K31.19365673
39FRK1.17021553
40PINK11.11067435
41SMG11.08009428
42PRKAA21.07653414
43TBK11.07488547
44EPHB11.06256641
45MAP3K71.06140550
46CDK71.05550326
47MAP3K101.01905451
48MAPK41.01735277
49JAK11.00932453
50ERBB21.00105277
51MAP3K110.97098251
52TIE10.92010103
53MET0.91016076
54MAP3K30.90465888
55PRKCZ0.88251072
56MAPK120.87266307
57FGR0.84631895
58KSR20.83751495
59MAPKAPK30.83252365
60EPHA30.82267663
61PRKACG0.81415056
62BRSK10.81094520
63CDK60.79230548
64MAP3K140.76739580
65DYRK1B0.76351481
66CSK0.73587152
67TGFBR20.73121427
68NEK20.71777142
69SGK10.71688796
70RPS6KB10.71458449
71NTRK30.71179542
72GSK3A0.68930904
73RIPK10.67377153
74CAMK2G0.66423910
75CDC42BPA0.66095580
76STK38L0.66052698
77PTK20.64306037
78MAP2K60.64289866
79NEK10.63830964
80PRKAA10.61536376
81STK390.60834700
82CSF1R0.60680247
83EPHA20.59891808
84CAMK1D0.59662676
85NTRK20.58568966
86SGK30.57783951
87MAPK70.55637520
88CDK80.55204972
89MAPK150.54815243
90IKBKE0.52499502
91PDPK10.52242129
92FGFR30.50777928
93EPHA40.50649634
94PRKCQ0.49565173
95GRK10.46531748
96MAP2K10.46218740
97TAOK20.45696755
98BRD40.44905338
99PRKCG0.44709919
100RET0.44701703
101CDK40.44553957
102MAP3K60.41140701
103PBK0.40644146
104ICK0.40348864
105CSNK1G10.39848661
106MATK0.39576767
107IGF1R0.39489374
108MAP3K50.39177354
109SGK20.38569853
110CSNK1D0.36796277
111MARK20.36284322
112SRC0.35837399
113MTOR0.35418658
114CSNK2A20.35330326
115MAP3K10.34878288
116EGFR0.33232714
117PDK10.33215757
118IRAK30.33096756
119CAMK40.32293355
120SGK4940.30719769
121SGK2230.30719769
122MAP3K130.30534067
123RPS6KA30.29420404
124MAP4K10.29031926
125BCR0.28890288
126MAP2K20.28702722
127PKN10.28021076
128CSNK2A10.27389852
129ALK0.27283921
130BRSK20.26727782
131RPS6KB20.26264412
132PRKCA0.26202611
133BMX0.25615043
134PDGFRB0.24743668
135CDK10.24136884
136MELK0.23716155
137CDK150.23167622
138MAPK100.21432773
139YES10.21395935
140PAK30.21347456
141MAP3K90.21226732
142PRKACB0.21069965
143CSNK1G20.20560651
144MAPKAPK50.20084331
145CSNK1G30.19515803
146LATS20.19250961
147MAPK30.17933534
148ABL10.16762407
149CSNK1E0.16394697

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.34740132
2Nitrogen metabolism_Homo sapiens_hsa009103.93422970
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.49349177
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.27968487
5Arginine biosynthesis_Homo sapiens_hsa002203.15667439
6Complement and coagulation cascades_Homo sapiens_hsa046102.91832469
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70866136
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68796726
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.60245801
10Tryptophan metabolism_Homo sapiens_hsa003802.58656373
11Fatty acid degradation_Homo sapiens_hsa000712.48057534
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33307862
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17248034
14Butanoate metabolism_Homo sapiens_hsa006502.13855756
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06966249
16Peroxisome_Homo sapiens_hsa041462.01989701
17Chemical carcinogenesis_Homo sapiens_hsa052041.91624458
18Staphylococcus aureus infection_Homo sapiens_hsa051501.89764176
19PPAR signaling pathway_Homo sapiens_hsa033201.89185180
20Histidine metabolism_Homo sapiens_hsa003401.87404757
21Propanoate metabolism_Homo sapiens_hsa006401.86877135
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86064462
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.83546384
24Fatty acid metabolism_Homo sapiens_hsa012121.83110952
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.79597889
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71963604
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.69158390
28beta-Alanine metabolism_Homo sapiens_hsa004101.67845471
29Other glycan degradation_Homo sapiens_hsa005111.66494248
30Selenocompound metabolism_Homo sapiens_hsa004501.63293151
31Retinol metabolism_Homo sapiens_hsa008301.59236514
32Phenylalanine metabolism_Homo sapiens_hsa003601.58220527
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57316915
34Caffeine metabolism_Homo sapiens_hsa002321.55109387
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53094695
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52897761
37Bile secretion_Homo sapiens_hsa049761.47660329
38Tyrosine metabolism_Homo sapiens_hsa003501.42386200
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.37056725
40Fatty acid elongation_Homo sapiens_hsa000621.34379466
41Sulfur metabolism_Homo sapiens_hsa009201.33430511
42Pyruvate metabolism_Homo sapiens_hsa006201.32435789
43Fat digestion and absorption_Homo sapiens_hsa049751.25820363
44Steroid biosynthesis_Homo sapiens_hsa001001.24837915
45Biosynthesis of amino acids_Homo sapiens_hsa012301.23573951
46Starch and sucrose metabolism_Homo sapiens_hsa005001.22875747
47Folate biosynthesis_Homo sapiens_hsa007901.20077838
48ABC transporters_Homo sapiens_hsa020101.18755583
49Carbon metabolism_Homo sapiens_hsa012001.13870420
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04974420
51Arginine and proline metabolism_Homo sapiens_hsa003300.99238280
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.98484972
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98079417
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.97404273
55Sulfur relay system_Homo sapiens_hsa041220.96504690
56Vitamin digestion and absorption_Homo sapiens_hsa049770.94883401
57Vitamin B6 metabolism_Homo sapiens_hsa007500.90273773
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88637449
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84063382
60N-Glycan biosynthesis_Homo sapiens_hsa005100.83735993
61Lysine degradation_Homo sapiens_hsa003100.78605122
62One carbon pool by folate_Homo sapiens_hsa006700.76901369
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70516996
64Glycerolipid metabolism_Homo sapiens_hsa005610.65768587
65Pentose phosphate pathway_Homo sapiens_hsa000300.64259623
66Glutathione metabolism_Homo sapiens_hsa004800.61748976
67Fatty acid biosynthesis_Homo sapiens_hsa000610.50506267
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46705231
69Metabolic pathways_Homo sapiens_hsa011000.45667165
70Mineral absorption_Homo sapiens_hsa049780.34431008
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28720684
72Galactose metabolism_Homo sapiens_hsa000520.28476468
73Sphingolipid metabolism_Homo sapiens_hsa006000.27477853
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26332126
75Fructose and mannose metabolism_Homo sapiens_hsa000510.26282086
76ECM-receptor interaction_Homo sapiens_hsa045120.25127964
77Prion diseases_Homo sapiens_hsa050200.24689450
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23825653
79Insulin resistance_Homo sapiens_hsa049310.23755097
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.23300652
81Linoleic acid metabolism_Homo sapiens_hsa005910.22348996
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21511658
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.15972983
84HIF-1 signaling pathway_Homo sapiens_hsa040660.15494761
85Non-small cell lung cancer_Homo sapiens_hsa052230.12844860
86Glucagon signaling pathway_Homo sapiens_hsa049220.10351571
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09760680
88AMPK signaling pathway_Homo sapiens_hsa041520.03041628
89Ether lipid metabolism_Homo sapiens_hsa00565-0.2440417
90Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2439704
91Pertussis_Homo sapiens_hsa05133-0.2351006
92Bladder cancer_Homo sapiens_hsa05219-0.2323571
93Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2172896
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1953474
95Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1939874
96Regulation of autophagy_Homo sapiens_hsa04140-0.1832409
97Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1763526
98Hepatitis C_Homo sapiens_hsa05160-0.1711845
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1595300
100Renin-angiotensin system_Homo sapiens_hsa04614-0.1513795
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1476975
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1470571
103Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1381156
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1005908
105African trypanosomiasis_Homo sapiens_hsa05143-0.0921817
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0819820
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0741370
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0712054
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532-0.0682952
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0336263

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