AHSP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a molecular chaperone which binds specifically to free alpha-globin and is involved in hemoglobin assembly. The encoded protein binds to monomeric alpha-globin until it has been transferred to beta-globin to form a heterodimer, which in turn binds to another heterodimer to form the stable tetrameric hemoglobin. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heme metabolic process (GO:0042168)9.23143205
2* hemoglobin metabolic process (GO:0020027)8.52275043
3erythrocyte development (GO:0048821)8.33059625
4tetrapyrrole metabolic process (GO:0033013)6.44254864
5response to methylmercury (GO:0051597)6.37225550
6myeloid cell development (GO:0061515)5.80972703
7regulation of response to osmotic stress (GO:0047484)5.69252031
8negative regulation of erythrocyte differentiation (GO:0045647)5.35078207
9hydrogen peroxide catabolic process (GO:0042744)4.75085989
10granulocyte differentiation (GO:0030851)4.71787521
11pigment biosynthetic process (GO:0046148)4.65101048
12iron ion import (GO:0097286)4.50764173
13response to insecticide (GO:0017085)4.42067149
14erythrocyte differentiation (GO:0030218)4.40540008
15glycine transport (GO:0015816)4.37127690
16positive regulation of granulocyte differentiation (GO:0030854)4.34239083
17innate immune response in mucosa (GO:0002227)4.21594512
18pigment metabolic process (GO:0042440)4.18969831
19antibacterial humoral response (GO:0019731)4.18764854
20response to lead ion (GO:0010288)4.15428997
21embryonic hemopoiesis (GO:0035162)3.98632157
22bicarbonate transport (GO:0015701)3.98349332
23response to arsenic-containing substance (GO:0046685)3.97125007
24regulation of erythrocyte differentiation (GO:0045646)3.86742575
25antimicrobial humoral response (GO:0019730)3.85221820
26disruption of cells of other organism (GO:0044364)3.78622069
27killing of cells of other organism (GO:0031640)3.78622069
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.76092468
29defense response to fungus (GO:0050832)3.71515946
30positive regulation of megakaryocyte differentiation (GO:0045654)3.57516722
31very-low-density lipoprotein particle assembly (GO:0034379)3.55552125
32megakaryocyte development (GO:0035855)3.54591373
33one-carbon compound transport (GO:0019755)3.51168849
34DNA topological change (GO:0006265)3.50638108
35definitive hemopoiesis (GO:0060216)3.46170254
36mucosal immune response (GO:0002385)3.41155086
37actin filament capping (GO:0051693)3.40227204
38positive regulation of erythrocyte differentiation (GO:0045648)3.38296032
39platelet formation (GO:0030220)3.28458344
403-UTR-mediated mRNA stabilization (GO:0070935)3.27458019
41protein-cofactor linkage (GO:0018065)3.22219622
42organ or tissue specific immune response (GO:0002251)3.17882118
43cellular response to arsenic-containing substance (GO:0071243)3.16857256
44neutrophil activation involved in immune response (GO:0002283)3.12441197
45positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.09175875
46hydrogen peroxide metabolic process (GO:0042743)3.01585994
472-deoxyribonucleotide biosynthetic process (GO:0009265)2.99005254
48deoxyribose phosphate biosynthetic process (GO:0046385)2.99005254
49cellular response to thyroid hormone stimulus (GO:0097067)2.91613132
50cofactor biosynthetic process (GO:0051188)2.86091983
51regulation of granulocyte differentiation (GO:0030852)2.82945468
52potassium ion export (GO:0071435)2.82516045
53regulation of RNA export from nucleus (GO:0046831)2.81423676
54modulation by virus of host process (GO:0019054)2.81045921
55protein targeting to plasma membrane (GO:0072661)2.77531859
56deoxyribonucleotide biosynthetic process (GO:0009263)2.70904257
57intracellular estrogen receptor signaling pathway (GO:0030520)2.70109325
58negative regulation of viral entry into host cell (GO:0046597)2.70000263
59negative regulation of actin filament depolymerization (GO:0030835)2.66206831
60iron ion homeostasis (GO:0055072)2.63320709
61response to fungus (GO:0009620)2.60946295
62positive regulation of fibroblast migration (GO:0010763)2.58174229
63response to superoxide (GO:0000303)2.51507552
64response to oxygen radical (GO:0000305)2.49906236
65regulation of histone H3-K9 methylation (GO:0051570)2.48493805
66mitochondrion degradation (GO:0000422)2.40357876
67* hemopoiesis (GO:0030097)2.39704718
68positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39176286
69mitotic chromosome condensation (GO:0007076)2.38696662
70disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.37495743
71killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.37495743
72cellular response to virus (GO:0098586)2.35237395
73cellular response to oxygen radical (GO:0071450)2.34987342
74removal of superoxide radicals (GO:0019430)2.34987342
75cellular response to superoxide (GO:0071451)2.34987342
76granulocyte activation (GO:0036230)2.34836734
77detection of bacterium (GO:0016045)2.33612360
78neutrophil activation (GO:0042119)2.32673847
79response to peptidoglycan (GO:0032494)2.31237810
80regulation of platelet aggregation (GO:0090330)2.27138319
81regulation of nucleobase-containing compound transport (GO:0032239)2.27101877
82purine-containing compound salvage (GO:0043101)2.25046908
83cellular response to dexamethasone stimulus (GO:0071549)2.24828712
84negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.23848564
85modulation by symbiont of host cellular process (GO:0044068)2.23096585
86detection of other organism (GO:0098543)2.22494811
87defense response to Gram-positive bacterium (GO:0050830)2.19607061
88positive regulation of B cell differentiation (GO:0045579)2.18832728
89pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.17972296
90plasma lipoprotein particle assembly (GO:0034377)2.16862570
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.14313833
92protoporphyrinogen IX metabolic process (GO:0046501)16.9150442
93oxygen transport (GO:0015671)15.0724672
94protoporphyrinogen IX biosynthetic process (GO:0006782)14.7965603
95gas transport (GO:0015669)13.3188297
96porphyrin-containing compound biosynthetic process (GO:0006779)12.2292771
97tetrapyrrole biosynthetic process (GO:0033014)10.9217801
98heme biosynthetic process (GO:0006783)10.7735598
99porphyrin-containing compound metabolic process (GO:0006778)10.3314542
100erythrocyte maturation (GO:0043249)10.0891766

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human8.67077237
2E2F7_22180533_ChIP-Seq_HELA_Human7.05165916
3GATA1_19941826_ChIP-Seq_K562_Human5.62305563
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.67413589
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.02825275
6GATA2_19941826_ChIP-Seq_K562_Human3.42361564
7SCL_19346495_ChIP-Seq_HPC-7_Human3.39467513
8TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.09540842
9GATA1_19941827_ChIP-Seq_MEL_Mouse2.76012165
10KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.70404588
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.23390061
12GATA1_22383799_ChIP-Seq_G1ME_Mouse2.15973587
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07801393
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03570579
15VDR_21846776_ChIP-Seq_THP-1_Human1.97274013
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92340056
17MYC_22102868_ChIP-Seq_BL_Human1.85132218
18GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.74763375
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71996889
20THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69709012
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61694300
22NCOR1_26117541_ChIP-Seq_K562_Human1.60457101
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59831190
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55010840
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54275456
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.50018943
27GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41453534
28SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41107728
29MAF_26560356_Chip-Seq_TH1_Human1.40912423
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.39822563
31VDR_24763502_ChIP-Seq_THP-1_Human1.38840695
32TCF7_22412390_ChIP-Seq_EML_Mouse1.36736962
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.30997717
34TFEB_21752829_ChIP-Seq_HELA_Human1.30905294
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28000014
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26113011
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.25694397
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25228820
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.24418897
40UTX_26944678_Chip-Seq_JUKART_Human1.24173865
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23360045
42* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23067159
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21106865
44BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20635936
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19926198
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19021156
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18713207
48FOXP3_21729870_ChIP-Seq_TREG_Human1.18273361
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.18021570
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.18015544
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17319101
52SPI1_23547873_ChIP-Seq_NB4_Human1.17034519
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15940922
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11934753
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11933175
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11537148
57DCP1A_22483619_ChIP-Seq_HELA_Human1.11478481
58CIITA_25753668_ChIP-Seq_RAJI_Human1.10814104
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10601822
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10557622
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.08873058
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08806543
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08600766
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07770794
65MYB_26560356_Chip-Seq_TH1_Human1.07683960
66VDR_23849224_ChIP-Seq_CD4+_Human1.06253621
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06215515
68BCOR_27268052_Chip-Seq_Bcells_Human1.04322742
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03263214
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02972005
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02053057
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01692517
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01525149
74XRN2_22483619_ChIP-Seq_HELA_Human0.98155878
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98146168
76BCL6_27268052_Chip-Seq_Bcells_Human0.97810754
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97700162
78AR_21909140_ChIP-Seq_LNCAP_Human0.97537944
79KDM2B_26808549_Chip-Seq_DND41_Human0.97480948
80MYB_26560356_Chip-Seq_TH2_Human0.96949692
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96539153
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96444671
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94164975
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94062626
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93091147
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92308316
87KDM5A_27292631_Chip-Seq_BREAST_Human0.91994060
88MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91283609
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90845107
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90678536
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.89498110
92SPI1_23127762_ChIP-Seq_K562_Human0.88581593
93MAF_26560356_Chip-Seq_TH2_Human0.88231291
94E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87856711
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87713345
96NANOG_21062744_ChIP-ChIP_HESCs_Human0.87219212
97ETS1_22383799_ChIP-Seq_G1ME_Mouse0.84322620
98CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82089599
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81075959
100P68_20966046_ChIP-Seq_HELA_Human0.81045128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo9.93962607
2MP0005083_abnormal_biliary_tract4.95204196
3MP0005397_hematopoietic_system_phenotyp3.52506040
4MP0001545_abnormal_hematopoietic_system3.52506040
5MP0003303_peritoneal_inflammation2.20807997
6MP0005636_abnormal_mineral_homeostasis2.12005120
7MP0003111_abnormal_nucleus_morphology2.11722492
8MP0009278_abnormal_bone_marrow2.04917913
9MP0004147_increased_porphyrin_level11.0617449
10MP0008260_abnormal_autophagy1.85120561
11MP0005377_hearing/vestibular/ear_phenot1.75225899
12MP0003878_abnormal_ear_physiology1.75225899
13MP0002396_abnormal_hematopoietic_system1.74433123
14MP0008995_early_reproductive_senescence1.72443893
15MP0001529_abnormal_vocalization1.69225328
16MP0002132_abnormal_respiratory_system1.55416957
17MP0003191_abnormal_cellular_cholesterol1.53794840
18MP0003172_abnormal_lysosome_physiology1.45658446
19* MP0002398_abnormal_bone_marrow1.38803990
20MP0005464_abnormal_platelet_physiology1.31172614
21MP0006036_abnormal_mitochondrial_physio1.30703707
22* MP0002722_abnormal_immune_system1.29295583
23MP0004145_abnormal_muscle_electrophysio1.22316085
24* MP0000689_abnormal_spleen_morphology1.21137151
25MP0008057_abnormal_DNA_replication1.20776326
26MP0003806_abnormal_nucleotide_metabolis1.19522835
27MP0004808_abnormal_hematopoietic_stem1.17813734
28MP0010094_abnormal_chromosome_stability1.15966727
29MP0003077_abnormal_cell_cycle1.11725235
30MP0008058_abnormal_DNA_repair1.11410923
31MP0004957_abnormal_blastocyst_morpholog1.09111803
32MP0009764_decreased_sensitivity_to1.07688157
33MP0005025_abnormal_response_to1.07356408
34MP0005075_abnormal_melanosome_morpholog1.06127369
35MP0009333_abnormal_splenocyte_physiolog1.05823480
36MP0002095_abnormal_skin_pigmentation1.03334966
37MP0000685_abnormal_immune_system1.03234833
38* MP0002429_abnormal_blood_cell1.02169791
39MP0003045_fibrosis1.01588487
40* MP0009931_abnormal_skin_appearance0.98672616
41* MP0003186_abnormal_redox_activity0.97773089
42MP0010307_abnormal_tumor_latency0.97089745
43MP0009785_altered_susceptibility_to0.94177892
44MP0003786_premature_aging0.93313985
45MP0000703_abnormal_thymus_morphology0.92164106
46MP0002405_respiratory_system_inflammati0.92152078
47MP0009765_abnormal_xenobiotic_induced0.91139480
48MP0000015_abnormal_ear_pigmentation0.88730482
49MP0008775_abnormal_heart_ventricle0.87570959
50MP0000749_muscle_degeneration0.86839728
51MP0002419_abnormal_innate_immunity0.86556851
52* MP0000313_abnormal_cell_death0.86326278
53MP0000609_abnormal_liver_physiology0.83966256
54MP0003436_decreased_susceptibility_to0.83380174
55MP0002009_preneoplasia0.75786698
56MP0005076_abnormal_cell_differentiation0.74664706
57MP0003763_abnormal_thymus_physiology0.74529623
58MP0002019_abnormal_tumor_incidence0.74478826
59MP0002166_altered_tumor_susceptibility0.71533279
60MP0002420_abnormal_adaptive_immunity0.70552228
61MP0003693_abnormal_embryo_hatching0.69125160
62MP0001819_abnormal_immune_cell0.68969395
63MP0000598_abnormal_liver_morphology0.68521361
64MP0000716_abnormal_immune_system0.68311958
65MP0006035_abnormal_mitochondrial_morpho0.68100428
66MP0002653_abnormal_ependyma_morphology0.67899081
67MP0009763_increased_sensitivity_to0.62104248
68MP0000490_abnormal_crypts_of0.60445507
69* MP0002080_prenatal_lethality0.59429339
70MP0005451_abnormal_body_composition0.57339508
71MP0008872_abnormal_physiological_respon0.57158686
72MP0009697_abnormal_copulation0.56120144
73MP0005000_abnormal_immune_tolerance0.54429041
74MP0002332_abnormal_exercise_endurance0.53353054
75MP0004947_skin_inflammation0.52888090
76MP0005319_abnormal_enzyme/_coenzyme0.51834583
77MP0005621_abnormal_cell_physiology0.51822632
78MP0000343_altered_response_to0.50852052
79MP0001697_abnormal_embryo_size0.50738373
80MP0001730_embryonic_growth_arrest0.48897869
81MP0002086_abnormal_extraembryonic_tissu0.48537220
82MP0008789_abnormal_olfactory_epithelium0.47241496
83MP0004185_abnormal_adipocyte_glucose0.47063992
84MP0000350_abnormal_cell_proliferation0.45704845
85MP0005384_cellular_phenotype0.45115522
86MP0009643_abnormal_urine_homeostasis0.44593750
87MP0003984_embryonic_growth_retardation0.43338995
88MP0002452_abnormal_antigen_presenting0.42899913
89MP0005647_abnormal_sex_gland0.42682309
90MP0002723_abnormal_immune_serum0.41848243
91MP0005266_abnormal_metabolism0.41797947
92MP0001790_abnormal_immune_system0.41374004
93MP0005387_immune_system_phenotype0.41374004
94MP0005501_abnormal_skin_physiology0.41192071
95MP0002088_abnormal_embryonic_growth/wei0.40637220
96MP0008469_abnormal_protein_level0.40075538
97MP0003221_abnormal_cardiomyocyte_apopto0.38358244
98MP0001835_abnormal_antigen_presentation0.38223431
99MP0001845_abnormal_inflammatory_respons0.37904950
100MP0004130_abnormal_muscle_cell0.37722942

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)8.49549499
2Reticulocytosis (HP:0001923)8.09447255
3Microcytic anemia (HP:0001935)7.29241878
4Cholelithiasis (HP:0001081)6.49311621
5Hypochromic anemia (HP:0001931)6.33561357
6Polycythemia (HP:0001901)6.31421455
7Acanthocytosis (HP:0001927)5.94415643
8Abnormal gallbladder morphology (HP:0012437)5.88014248
9Paralysis (HP:0003470)5.77502290
10Abnormality of reticulocytes (HP:0004312)5.53918315
11Diaphragmatic weakness (HP:0009113)4.51378759
12Hyperbilirubinemia (HP:0002904)4.37840822
13Abnormality of the gallbladder (HP:0005264)4.28920823
14Cholecystitis (HP:0001082)4.16801935
15Abnormal gallbladder physiology (HP:0012438)4.16801935
16Ileus (HP:0002595)4.05121414
17Toxemia of pregnancy (HP:0100603)3.92484927
18Abnormality of iron homeostasis (HP:0011031)3.84804168
19Pallor (HP:0000980)3.68922101
20Abnormality of transition element cation homeostasis (HP:0011030)3.48524657
21Abnormal number of erythroid precursors (HP:0012131)3.35025451
22Prolonged bleeding time (HP:0003010)3.20033824
23Abnormality of cells of the erythroid lineage (HP:0012130)2.99017317
24Cutaneous photosensitivity (HP:0000992)2.98899802
25Cerebral palsy (HP:0100021)2.98370522
26Hepatocellular carcinoma (HP:0001402)2.86436521
27Increased serum ferritin (HP:0003281)2.82307477
28Nausea (HP:0002018)2.68311288
29Insomnia (HP:0100785)2.65377662
30Nonimmune hydrops fetalis (HP:0001790)2.45728837
31Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.45483310
32Osteomalacia (HP:0002749)2.41394309
33Hypertensive crisis (HP:0100735)2.11998845
34Petechiae (HP:0000967)2.11920610
35Abnormality of the fingertips (HP:0001211)2.10986781
36Gastrointestinal infarctions (HP:0005244)2.09409709
37Abnormality of the heme biosynthetic pathway (HP:0010472)16.6096666
38Hypochromic microcytic anemia (HP:0004840)11.0929391
39Poikilocytosis (HP:0004447)10.1335455
40Hyponatremia (HP:0002902)1.99257035
41Epistaxis (HP:0000421)1.98830493
42Abnormality of sodium homeostasis (HP:0010931)1.93429793
43Neoplasm of the liver (HP:0002896)1.92615695
44Osteomyelitis (HP:0002754)1.91393252
45Urticaria (HP:0001025)1.86477199
46Visual hallucinations (HP:0002367)1.83256007
47Onycholysis (HP:0001806)1.80601160
48Ventricular fibrillation (HP:0001663)1.79227206
49Impaired platelet aggregation (HP:0003540)1.72322407
50Abnormal platelet function (HP:0011869)1.72322407
51Gastrointestinal dysmotility (HP:0002579)1.67203155
52Pustule (HP:0200039)1.66130013
53Thrombophlebitis (HP:0004418)1.63432344
54Paresthesia (HP:0003401)1.63047083
55Hypoparathyroidism (HP:0000829)1.59429201
56Autoimmune thrombocytopenia (HP:0001973)1.57832273
57Aplasia/Hypoplasia of the earlobes (HP:0009906)1.57315503
58Short middle phalanx of the 5th finger (HP:0004220)1.56068203
59Albinism (HP:0001022)1.55457005
60Abnormal platelet volume (HP:0011876)1.54897335
61Abnormal delayed hypersensitivity skin test (HP:0002963)1.51466105
62Recurrent abscess formation (HP:0002722)1.51418172
63Slow saccadic eye movements (HP:0000514)1.48520653
64Skin rash (HP:0000988)1.47991601
65Autoimmune hemolytic anemia (HP:0001890)1.44285565
66Splenomegaly (HP:0001744)1.43613177
67Anorexia (HP:0002039)1.42977353
68Hypertriglyceridemia (HP:0002155)1.42864130
69Chromosomal breakage induced by crosslinking agents (HP:0003221)1.42655457
70Abnormality of dental color (HP:0011073)1.40985939
71Increased mean platelet volume (HP:0011877)1.40463666
72Bone marrow hypocellularity (HP:0005528)1.40059870
73Spontaneous hematomas (HP:0007420)1.39461554
74Prenatal maternal abnormality (HP:0002686)1.36924759
75Recurrent bacterial skin infections (HP:0005406)1.32620496
76Severe visual impairment (HP:0001141)1.32006616
77Orthostatic hypotension (HP:0001278)1.29479752
78Hepatosplenomegaly (HP:0001433)1.28876983
79Chromsome breakage (HP:0040012)1.27952375
80Abnormal blistering of the skin (HP:0008066)1.25696459
81Cellulitis (HP:0100658)1.22646889
82Recurrent viral infections (HP:0004429)1.21651685
83Eczematoid dermatitis (HP:0000976)1.20798820
84Encephalitis (HP:0002383)1.19554807
85Peripheral hypomyelination (HP:0007182)1.19226255
86Inflammation of the large intestine (HP:0002037)1.18694205
87Keratoconjunctivitis sicca (HP:0001097)1.18105677
88Abnormality of renal resorption (HP:0011038)1.17261515
89Abnormality of T cell physiology (HP:0011840)1.16540061
90Panhypogammaglobulinemia (HP:0003139)1.15882215
91Increased IgM level (HP:0003496)1.15833672
92Obstructive lung disease (HP:0006536)1.15588025
93Chronic obstructive pulmonary disease (HP:0006510)1.15588025
94Gastrointestinal inflammation (HP:0004386)1.15400987
95Hematochezia (HP:0002573)1.14722559
96Gingival bleeding (HP:0000225)1.12785652
97Metaphyseal cupping (HP:0003021)1.12083070
98Renal tubular acidosis (HP:0001947)1.09510686
99Biliary tract neoplasm (HP:0100574)1.09316006
100Keratoconjunctivitis (HP:0001096)1.07416722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK18.08135103
2PRPF4B4.63271280
3MAP2K33.91491548
4MAP3K113.37581609
5TAOK23.36475844
6TAOK13.31613734
7GRK62.44047022
8SCYL22.28224307
9MAP3K32.08667694
10PIM11.98161590
11DYRK31.97181337
12CLK11.89042637
13BUB11.82963450
14BMX1.66503957
15STK41.62051976
16MARK31.55854303
17CDC71.39757166
18MAP3K51.28980880
19RPS6KA51.24867159
20WNK11.22343625
21TNK21.19730016
22SYK1.17210438
23RIPK41.13905720
24MAP3K101.13352629
25CAMK1D1.09657341
26MAP3K11.08761918
27PLK41.07748701
28PLK31.00787072
29HIPK20.99200715
30TRPM70.98677004
31MAP4K10.96651697
32MAP3K60.90527365
33MAP3K80.88426117
34PTK2B0.87514857
35SMG10.87413578
36BTK0.83868278
37RPS6KC10.83028449
38RPS6KL10.83028449
39JAK20.81932578
40MAP2K40.81224853
41PLK10.80648999
42BRSK10.79981896
43VRK20.79006820
44BRAF0.76782438
45CDK40.75039834
46ZAP700.74797987
47TESK20.74029945
48CDK120.73055090
49ZAK0.71749683
50IRAK40.70976448
51RPS6KA60.70912374
52BRSK20.69142939
53LYN0.68663796
54MAP2K10.66504517
55TEC0.66172936
56IKBKE0.65666180
57FGR0.61981011
58VRK10.61378668
59STK110.58702703
60CHEK20.56624053
61SGK30.55296227
62TAF10.53920683
63NEK20.53645279
64IKBKB0.52658950
65PRKAA20.52405118
66TYK20.51672398
67DYRK1B0.50176468
68MAP2K20.48801296
69SGK20.48154274
70SGK10.46406067
71ABL20.46392389
72RAF10.44750217
73BLK0.44669866
74FES0.43613740
75CHEK10.43471387
76TLK10.43444505
77JAK30.42958217
78TTK0.42496700
79AKT10.41714140
80GRK50.41141844
81CCNB10.41061689
82ERN10.40912182
83KSR10.39510385
84PBK0.37217462
85MAPK120.35044750
86ATM0.34835979
87AURKA0.33683514
88NME20.33328697
89ATR0.30829139
90PRKACG0.29513907
91HCK0.29490188
92AURKB0.29391297
93MAPK110.28253426
94CDK20.27321009
95CDK60.26895228
96MAPK30.26725984
97SIK10.25908080
98DYRK20.25841394
99TBK10.25601422
100MST40.24875611

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008607.29711116
2Malaria_Homo sapiens_hsa051444.60396641
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.73322260
4Nitrogen metabolism_Homo sapiens_hsa009103.18807482
5DNA replication_Homo sapiens_hsa030302.90857398
6African trypanosomiasis_Homo sapiens_hsa051432.58006362
7Cell cycle_Homo sapiens_hsa041101.97035460
8Mismatch repair_Homo sapiens_hsa034301.94043053
9Collecting duct acid secretion_Homo sapiens_hsa049661.93759868
10Regulation of autophagy_Homo sapiens_hsa041401.90536804
11Base excision repair_Homo sapiens_hsa034101.77860914
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67580257
13Non-small cell lung cancer_Homo sapiens_hsa052231.64514108
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.63877532
15Acute myeloid leukemia_Homo sapiens_hsa052211.57426846
16Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.56889806
17Hematopoietic cell lineage_Homo sapiens_hsa046401.52953794
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49146658
19Fanconi anemia pathway_Homo sapiens_hsa034601.48401380
20Pancreatic cancer_Homo sapiens_hsa052121.44200483
21Chronic myeloid leukemia_Homo sapiens_hsa052201.40410755
22Nucleotide excision repair_Homo sapiens_hsa034201.37066284
23Homologous recombination_Homo sapiens_hsa034401.33270789
24Systemic lupus erythematosus_Homo sapiens_hsa053221.29797503
25Non-homologous end-joining_Homo sapiens_hsa034501.25704798
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21200909
27One carbon pool by folate_Homo sapiens_hsa006701.15699965
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.12290157
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.06369357
30Herpes simplex infection_Homo sapiens_hsa051681.01438048
31Bladder cancer_Homo sapiens_hsa052190.98950712
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96729388
33Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95265335
34Apoptosis_Homo sapiens_hsa042100.93470286
35Viral carcinogenesis_Homo sapiens_hsa052030.93201086
36Spliceosome_Homo sapiens_hsa030400.92118525
37FoxO signaling pathway_Homo sapiens_hsa040680.91207183
38Hepatitis B_Homo sapiens_hsa051610.90389981
39Jak-STAT signaling pathway_Homo sapiens_hsa046300.90210339
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89935816
41Osteoclast differentiation_Homo sapiens_hsa043800.88802361
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84013298
43Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82652384
44Pyrimidine metabolism_Homo sapiens_hsa002400.82605309
45Renal cell carcinoma_Homo sapiens_hsa052110.82503785
46Alcoholism_Homo sapiens_hsa050340.81923286
47B cell receptor signaling pathway_Homo sapiens_hsa046620.80825464
48ABC transporters_Homo sapiens_hsa020100.80672046
49Hepatitis C_Homo sapiens_hsa051600.74463109
50HIF-1 signaling pathway_Homo sapiens_hsa040660.73714457
51Measles_Homo sapiens_hsa051620.69780465
52Endometrial cancer_Homo sapiens_hsa052130.69094242
53Carbon metabolism_Homo sapiens_hsa012000.62912481
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62633427
55Mineral absorption_Homo sapiens_hsa049780.61700833
56Pentose phosphate pathway_Homo sapiens_hsa000300.61181153
57Small cell lung cancer_Homo sapiens_hsa052220.60924042
58Type II diabetes mellitus_Homo sapiens_hsa049300.60783854
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60533758
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59755604
61Leishmaniasis_Homo sapiens_hsa051400.59425746
62Epstein-Barr virus infection_Homo sapiens_hsa051690.58629788
63AMPK signaling pathway_Homo sapiens_hsa041520.58269088
64Fatty acid elongation_Homo sapiens_hsa000620.57566386
65HTLV-I infection_Homo sapiens_hsa051660.56673609
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55933357
67mTOR signaling pathway_Homo sapiens_hsa041500.55598152
68p53 signaling pathway_Homo sapiens_hsa041150.55359986
69Asthma_Homo sapiens_hsa053100.54827577
70Pyruvate metabolism_Homo sapiens_hsa006200.54140866
71Influenza A_Homo sapiens_hsa051640.53992529
72Tuberculosis_Homo sapiens_hsa051520.53444271
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53416166
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52966332
75Proteasome_Homo sapiens_hsa030500.50591950
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49343106
77Oocyte meiosis_Homo sapiens_hsa041140.48908798
78Prostate cancer_Homo sapiens_hsa052150.48276413
79Purine metabolism_Homo sapiens_hsa002300.48019534
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46884324
81Thyroid cancer_Homo sapiens_hsa052160.46805257
82Glioma_Homo sapiens_hsa052140.46157479
83Glutathione metabolism_Homo sapiens_hsa004800.44468976
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.43558513
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43074068
86Fructose and mannose metabolism_Homo sapiens_hsa000510.40258441
87Primary immunodeficiency_Homo sapiens_hsa053400.39407051
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39014863
89Inositol phosphate metabolism_Homo sapiens_hsa005620.37584242
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.35444403
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33367867
92RNA transport_Homo sapiens_hsa030130.32287225
93Platelet activation_Homo sapiens_hsa046110.30483371
94Fatty acid biosynthesis_Homo sapiens_hsa000610.29676047
95T cell receptor signaling pathway_Homo sapiens_hsa046600.29507067
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29398085
97TNF signaling pathway_Homo sapiens_hsa046680.27951597
98Prolactin signaling pathway_Homo sapiens_hsa049170.27435164
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26060768
100Melanoma_Homo sapiens_hsa052180.25421343

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