AICDA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* somatic diversification of immune receptors via somatic mutation (GO:0002566)8.22160719
2* somatic hypermutation of immunoglobulin genes (GO:0016446)8.22160719
3regulation of B cell receptor signaling pathway (GO:0050855)8.07223471
4B cell receptor signaling pathway (GO:0050853)7.49528468
5CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)6.43676107
6antigen processing and presentation of endogenous antigen (GO:0019883)6.41517826
7cellular response to zinc ion (GO:0071294)6.36637899
8regulation of germinal center formation (GO:0002634)6.03684956
9telomere maintenance via semi-conservative replication (GO:0032201)5.37875067
10negative regulation of B cell apoptotic process (GO:0002903)5.33673220
11* cytidine metabolic process (GO:0046087)5.09113675
12* cytidine catabolic process (GO:0006216)5.09113675
13* cytidine deamination (GO:0009972)5.09113675
14nucleotide-excision repair, DNA gap filling (GO:0006297)4.81591900
15B cell proliferation (GO:0042100)4.81358460
16DNA strand elongation involved in DNA replication (GO:0006271)4.78966245
17germinal center formation (GO:0002467)4.78337941
18regulation of B cell apoptotic process (GO:0002902)4.71609866
19telomere maintenance via recombination (GO:0000722)4.71566903
20positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.60408548
21DNA strand elongation (GO:0022616)4.51518514
22regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.47164781
23T cell lineage commitment (GO:0002360)4.44254188
24mitotic recombination (GO:0006312)4.42851937
25protein localization to kinetochore (GO:0034501)4.40933619
26regulation of B cell differentiation (GO:0045577)4.39005828
27regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.19861822
28mitotic sister chromatid segregation (GO:0000070)4.18188178
29regulation of B cell proliferation (GO:0030888)4.15569545
30DNA deamination (GO:0045006)4.14769483
31* somatic diversification of immunoglobulins (GO:0016445)4.09750680
32positive regulation of protein homooligomerization (GO:0032464)4.00082363
33positive thymic T cell selection (GO:0045059)3.96157501
34telomere maintenance via telomere lengthening (GO:0010833)3.89012792
35negative thymic T cell selection (GO:0045060)3.88002679
36positive regulation of defense response to virus by host (GO:0002230)3.82094383
37DNA replication checkpoint (GO:0000076)3.82084830
38sister chromatid segregation (GO:0000819)3.81626617
39B cell homeostasis (GO:0001782)3.77388403
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.77284305
41immunoglobulin mediated immune response (GO:0016064)3.77157534
42base-excision repair (GO:0006284)3.73058839
43positive regulation of B cell proliferation (GO:0030890)3.68216691
44positive regulation of gamma-delta T cell activation (GO:0046645)3.65308385
45mitotic chromosome condensation (GO:0007076)3.64843965
46B cell mediated immunity (GO:0019724)3.64524058
47regulation of dendritic cell antigen processing and presentation (GO:0002604)3.64191379
48complement activation, classical pathway (GO:0006958)3.62543240
49negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.61207252
50interferon-gamma-mediated signaling pathway (GO:0060333)3.55635527
51polyketide metabolic process (GO:0030638)3.53064623
52doxorubicin metabolic process (GO:0044598)3.53064623
53daunorubicin metabolic process (GO:0044597)3.53064623
54regulation of interferon-gamma biosynthetic process (GO:0045072)3.52234388
55negative T cell selection (GO:0043383)3.52156607
56protein localization to chromosome, centromeric region (GO:0071459)3.49667570
57regulation of MHC class I biosynthetic process (GO:0045343)3.49604746
58negative regulation of phagocytosis (GO:0050765)3.48384227
59mature B cell differentiation (GO:0002335)3.47821480
60positive regulation of macrophage cytokine production (GO:0060907)3.46967258
61DNA replication-dependent nucleosome assembly (GO:0006335)3.46522445
62DNA replication-dependent nucleosome organization (GO:0034723)3.46522445
63tryptophan metabolic process (GO:0006568)3.39948574
64positive regulation of humoral immune response (GO:0002922)3.36104326
65positive regulation of protein homodimerization activity (GO:0090073)3.35544860
66Arp2/3 complex-mediated actin nucleation (GO:0034314)3.34137225
67endoderm formation (GO:0001706)3.34051832
68regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.33498111
69formation of translation preinitiation complex (GO:0001731)3.31132656
70cellular response to interleukin-15 (GO:0071350)3.29496482
71histamine secretion (GO:0001821)3.29094375
72T cell migration (GO:0072678)3.28591512
73regulation of histone H3-K27 methylation (GO:0061085)3.26715226
74negative regulation of immunoglobulin mediated immune response (GO:0002890)3.25242875
75negative regulation of B cell mediated immunity (GO:0002713)3.25242875
76behavioral response to nicotine (GO:0035095)3.22455295
77natural killer cell mediated immunity (GO:0002228)3.22255398
78natural killer cell mediated cytotoxicity (GO:0042267)3.22255398
79mature B cell differentiation involved in immune response (GO:0002313)3.21170631
80* B cell activation (GO:0042113)3.20485632
81DNA replication initiation (GO:0006270)3.20251181
82indolalkylamine metabolic process (GO:0006586)3.20151070
83positive regulation of interleukin-12 production (GO:0032735)3.19048126
84positive regulation of type 2 immune response (GO:0002830)3.11443840
85regulation of B cell activation (GO:0050864)3.09978408
86positive regulation of B cell differentiation (GO:0045579)3.09660453
87lymphocyte homeostasis (GO:0002260)3.08696053
88response to type I interferon (GO:0034340)3.07363538
89chaperone mediated protein folding requiring cofactor (GO:0051085)3.06737344
90positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.05379778
91DNA unwinding involved in DNA replication (GO:0006268)3.04445580
92purine deoxyribonucleotide catabolic process (GO:0009155)3.03899715
93regulation of defense response to virus by host (GO:0050691)3.03771327
94thymic T cell selection (GO:0045061)3.03469440
95regulation of alpha-beta T cell proliferation (GO:0046640)3.01688228
96positive regulation of immunoglobulin mediated immune response (GO:0002891)3.00934474
97positive regulation of B cell mediated immunity (GO:0002714)3.00934474
98cellular response to type I interferon (GO:0071357)3.00734190
99type I interferon signaling pathway (GO:0060337)3.00734190
100negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.99918291
101* somatic diversification of immune receptors (GO:0002200)2.99794823
102positive regulation of B cell activation (GO:0050871)2.99566536
103positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.99419208
104positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98635571
105positive regulation of interferon-alpha production (GO:0032727)2.98630828
106attachment of spindle microtubules to kinetochore (GO:0008608)2.98050191
107immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.97873371
108Fc-gamma receptor signaling pathway (GO:0038094)2.97873371
109Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.97873371
110negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.97114611
111negative regulation of telomere maintenance (GO:0032205)2.97019500
112immune response-activating cell surface receptor signaling pathway (GO:0002429)2.96940925
113humoral immune response (GO:0006959)2.94853378
114telomere maintenance (GO:0000723)2.93637706
115positive regulation of antigen processing and presentation (GO:0002579)2.93599067
116Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.93133132
117telomere organization (GO:0032200)2.92808714
118* pyrimidine ribonucleoside catabolic process (GO:0046133)2.92790581
119regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.91926197
120regulation of interferon-alpha production (GO:0032647)2.90453779
121ribosomal small subunit assembly (GO:0000028)2.89770391
122DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.89508207
123deoxyribonucleotide catabolic process (GO:0009264)2.88440052
124antigen receptor-mediated signaling pathway (GO:0050851)2.88393735
125tryptophan catabolic process (GO:0006569)2.88322278
126indole-containing compound catabolic process (GO:0042436)2.88322278
127indolalkylamine catabolic process (GO:0046218)2.88322278
128negative regulation of B cell proliferation (GO:0030889)2.88234708
129regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.87773948
130L-fucose catabolic process (GO:0042355)2.87558556
131fucose catabolic process (GO:0019317)2.87558556
132L-fucose metabolic process (GO:0042354)2.87558556
133negative regulation of mast cell activation (GO:0033004)2.87537653
134regulation of gamma-delta T cell activation (GO:0046643)2.86575346
135mast cell activation (GO:0045576)2.84162518
136response to protozoan (GO:0001562)2.82171202
137mitotic metaphase plate congression (GO:0007080)2.80336347
138defense response to protozoan (GO:0042832)2.80152181
139cellular response to interferon-beta (GO:0035458)2.79679161
140nuclear pore complex assembly (GO:0051292)2.79305894
141interferon-gamma production (GO:0032609)2.79068943
142negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.78929528
143T cell costimulation (GO:0031295)2.77308640
144T-helper 1 type immune response (GO:0042088)2.76878886
145tolerance induction (GO:0002507)2.75778563
146lymphocyte costimulation (GO:0031294)2.75664483
147regulation of nuclear cell cycle DNA replication (GO:0033262)2.75558933
148regulation of T-helper cell differentiation (GO:0045622)2.74414532
149regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.74130005
150regulation of interferon-beta biosynthetic process (GO:0045357)2.74040838
151positive regulation of cAMP-mediated signaling (GO:0043950)2.73623533
152antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73110513
153positive regulation of alpha-beta T cell proliferation (GO:0046641)2.72644159
154cellular response to interferon-gamma (GO:0071346)2.71961277
155positive regulation of interleukin-2 production (GO:0032743)2.70452620
156regulation of DNA endoreduplication (GO:0032875)2.65655235
157positive regulation of cytokine biosynthetic process (GO:0042108)2.65065207
158kynurenine metabolic process (GO:0070189)2.62323069
159antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58407861
160protein K6-linked ubiquitination (GO:0085020)2.56949199
161response to interleukin-15 (GO:0070672)2.54885472
162positive regulation by symbiont of host defense response (GO:0052509)2.53573116
163modulation by symbiont of host defense response (GO:0052031)2.53573116
164modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.53573116
165modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.53573116
166positive regulation by organism of defense response of other organism involved in symbiotic interact2.53573116
167modulation by symbiont of host immune response (GO:0052553)2.53573116
168DNA damage response, signal transduction resulting in transcription (GO:0042772)2.53164194
169positive regulation of T-helper 1 type immune response (GO:0002827)2.52603708
170NIK/NF-kappaB signaling (GO:0038061)2.50585796
171water-soluble vitamin biosynthetic process (GO:0042364)2.49770837
172NADH dehydrogenase complex assembly (GO:0010257)2.47716422
173mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.47716422
174mitochondrial respiratory chain complex I assembly (GO:0032981)2.47716422
175positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.45949303
176protein K11-linked deubiquitination (GO:0035871)2.45748326
177negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.44403830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.25120140
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.99296650
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.65969434
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.40013806
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.35611300
6MYC_22102868_ChIP-Seq_BL_Human3.83080003
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.79464574
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53106485
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.47477090
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.44382962
11ZNF274_21170338_ChIP-Seq_K562_Hela3.14794254
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.14440698
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87940267
14EZH2_22144423_ChIP-Seq_EOC_Human2.87309835
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74673849
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61317427
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.59414927
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52495007
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.37321063
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.23798176
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09186656
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08800990
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03806697
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03313584
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02788538
26FOXP3_21729870_ChIP-Seq_TREG_Human2.02100952
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96292599
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95679831
29* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92117770
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.91368182
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.85127492
32SPI1_23547873_ChIP-Seq_NB4_Human1.77804640
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.77547691
34MYC_18940864_ChIP-ChIP_HL60_Human1.77446812
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77410282
36CIITA_25753668_ChIP-Seq_RAJI_Human1.75918231
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.73939950
38MYB_26560356_Chip-Seq_TH2_Human1.72210421
39MYB_26560356_Chip-Seq_TH1_Human1.70574298
40GATA3_26560356_Chip-Seq_TH2_Human1.65750240
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.65264442
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.63076852
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58550027
44VDR_22108803_ChIP-Seq_LS180_Human1.58454998
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56460101
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56068210
47EWS_26573619_Chip-Seq_HEK293_Human1.55592182
48MAF_26560356_Chip-Seq_TH1_Human1.54459028
49VDR_23849224_ChIP-Seq_CD4+_Human1.53455174
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53082766
51VDR_21846776_ChIP-Seq_THP-1_Human1.50762531
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50211952
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49780476
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49581815
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47818536
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45122187
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43067393
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42925143
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42157324
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41483826
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.39308530
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37788785
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.37759817
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37214119
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36330184
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34571997
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33092705
68AR_21909140_ChIP-Seq_LNCAP_Human1.31610520
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30924832
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30483767
71FUS_26573619_Chip-Seq_HEK293_Human1.28517187
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.28108307
73KDM5A_27292631_Chip-Seq_BREAST_Human1.27831825
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26519017
75ELK1_19687146_ChIP-ChIP_HELA_Human1.23786340
76UTX_26944678_Chip-Seq_JUKART_Human1.23682008
77XRN2_22483619_ChIP-Seq_HELA_Human1.23252034
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22459045
79SMRT_27268052_Chip-Seq_Bcells_Human1.19699394
80RUNX_20019798_ChIP-Seq_JUKART_Human1.19607894
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17878891
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17538655
83IGF1R_20145208_ChIP-Seq_DFB_Human1.17171300
84VDR_24763502_ChIP-Seq_THP-1_Human1.14938307
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14883119
86SCL_19346495_ChIP-Seq_HPC-7_Human1.14612838
87ER_23166858_ChIP-Seq_MCF-7_Human1.14310112
88* GATA3_26560356_Chip-Seq_TH1_Human1.13413886
89STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13222217
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.12463022
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11991386
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11448230
93MAF_26560356_Chip-Seq_TH2_Human1.11029134
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10437779
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10239451
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.09391199
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09391199
98TP53_22573176_ChIP-Seq_HFKS_Human1.08262617
99SPI1_23127762_ChIP-Seq_K562_Human1.06908560
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06581721
101DCP1A_22483619_ChIP-Seq_HELA_Human1.06144674
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05936403
103EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05049547
104NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04696776
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04261231
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02148475
107GABP_19822575_ChIP-Seq_HepG2_Human1.01437229
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01254027
109RUNX1_22412390_ChIP-Seq_EML_Mouse1.01055936
110NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00701357
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.00176912
112YY1_21170310_ChIP-Seq_MESCs_Mouse1.00113135
113CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00013190
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97326809
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97027277
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96903926
117POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96102731
118GATA3_27048872_Chip-Seq_THYMUS_Human0.95919564
119GATA3_21878914_ChIP-Seq_MCF-7_Human0.95033115
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.94348077
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94336767
122PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94040497
123GBX2_23144817_ChIP-Seq_PC3_Human0.93770330
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93423060
125HOXB7_26014856_ChIP-Seq_BT474_Human0.93195374
126BCAT_22108803_ChIP-Seq_LS180_Human0.93082896
127SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92698046
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92491325
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91428133
130GATA1_22025678_ChIP-Seq_K562_Human0.91214301
131SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90909130
132ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90724201
133KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90343003
134FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90262122
135PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86268428
136ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86021661
137E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85153239
138YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84583691
139IRF1_19129219_ChIP-ChIP_H3396_Human0.84348544
140* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83520533
141SOX2_19829295_ChIP-Seq_ESCs_Human0.82626124
142NANOG_19829295_ChIP-Seq_ESCs_Human0.82626124
143STAT3_23295773_ChIP-Seq_U87_Human0.82553754
144CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82195140
145CRX_20693478_ChIP-Seq_RETINA_Mouse0.81831565
146TTF2_22483619_ChIP-Seq_HELA_Human0.81148568
147* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76820554
148GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76311097
149E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76269936
150FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73681749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.04485005
2* MP0001800_abnormal_humoral_immune4.92611852
3MP0001790_abnormal_immune_system4.45812851
4MP0005387_immune_system_phenotype4.45812851
5MP0005645_abnormal_hypothalamus_physiol3.93569616
6MP0002138_abnormal_hepatobiliary_system3.87639866
7MP0008057_abnormal_DNA_replication3.75217381
8MP0000685_abnormal_immune_system3.71482784
9* MP0002452_abnormal_antigen_presenting3.59973234
10MP0005671_abnormal_response_to3.43958104
11MP0005000_abnormal_immune_tolerance3.01746570
12* MP0002723_abnormal_immune_serum2.97058323
13* MP0002420_abnormal_adaptive_immunity2.95831880
14* MP0002398_abnormal_bone_marrow2.86151400
15* MP0001819_abnormal_immune_cell2.85802064
16MP0000372_irregular_coat_pigmentation2.80130421
17MP0008872_abnormal_physiological_respon2.68514728
18* MP0010094_abnormal_chromosome_stability2.68325578
19MP0000689_abnormal_spleen_morphology2.64570745
20MP0002148_abnormal_hypersensitivity_rea2.63553685
21* MP0000716_abnormal_immune_system2.54387815
22MP0003077_abnormal_cell_cycle2.45409732
23MP0004957_abnormal_blastocyst_morpholog2.39513274
24MP0003303_peritoneal_inflammation2.33845417
25MP0003763_abnormal_thymus_physiology2.31940952
26MP0000013_abnormal_adipose_tissue2.23283710
27MP0003111_abnormal_nucleus_morphology2.21688277
28MP0002722_abnormal_immune_system2.20574026
29MP0003693_abnormal_embryo_hatching2.14624104
30* MP0002429_abnormal_blood_cell2.14499907
31MP0001853_heart_inflammation2.10551613
32MP0005025_abnormal_response_to1.93775453
33MP0005310_abnormal_salivary_gland1.81655698
34MP0002396_abnormal_hematopoietic_system1.80512998
35MP0002163_abnormal_gland_morphology1.78488897
36MP0009046_muscle_twitch1.78176236
37MP0002933_joint_inflammation1.72549212
38MP0002928_abnormal_bile_duct1.70080417
39MP0004510_myositis1.63885229
40MP0008058_abnormal_DNA_repair1.62897821
41MP0009785_altered_susceptibility_to1.62760479
42MP0002139_abnormal_hepatobiliary_system1.61436065
43MP0005084_abnormal_gallbladder_morpholo1.56751888
44MP0002405_respiratory_system_inflammati1.52531349
45MP0002419_abnormal_innate_immunity1.43114922
46* MP0002019_abnormal_tumor_incidence1.37842408
47MP0000703_abnormal_thymus_morphology1.37583373
48MP0001348_abnormal_lacrimal_gland1.36160929
49MP0003252_abnormal_bile_duct1.35591193
50MP0003183_abnormal_peptide_metabolism1.34788786
51MP0001845_abnormal_inflammatory_respons1.34264601
52MP0004142_abnormal_muscle_tone1.27169229
53MP0010352_gastrointestinal_tract_polyps1.24653931
54MP0000350_abnormal_cell_proliferation1.22315577
55MP0001873_stomach_inflammation1.19584152
56MP0006292_abnormal_olfactory_placode1.18221721
57MP0004145_abnormal_muscle_electrophysio1.17290007
58MP0006082_CNS_inflammation1.17062597
59MP0002166_altered_tumor_susceptibility1.15119491
60MP0005551_abnormal_eye_electrophysiolog1.14120246
61MP0004808_abnormal_hematopoietic_stem1.13807340
62MP0003436_decreased_susceptibility_to1.12314953
63MP0002876_abnormal_thyroid_physiology1.09602018
64MP0002693_abnormal_pancreas_physiology1.09268969
65MP0000313_abnormal_cell_death1.07208816
66MP0008007_abnormal_cellular_replicative1.05994549
67MP0002837_dystrophic_cardiac_calcinosis1.05547576
68MP0008961_abnormal_basal_metabolism1.00815718
69MP0005171_absent_coat_pigmentation1.00423990
70MP0002653_abnormal_ependyma_morphology0.97140019
71MP0004947_skin_inflammation0.96444170
72MP0004742_abnormal_vestibular_system0.96007358
73MP0001986_abnormal_taste_sensitivity0.95949691
74MP0000631_abnormal_neuroendocrine_gland0.95899355
75MP0000003_abnormal_adipose_tissue0.95863158
76MP0002735_abnormal_chemical_nociception0.95750219
77MP0001730_embryonic_growth_arrest0.93019493
78MP0005220_abnormal_exocrine_pancreas0.92579102
79MP0002102_abnormal_ear_morphology0.91376728
80MP0001968_abnormal_touch/_nociception0.88240784
81MP0006072_abnormal_retinal_apoptosis0.87744253
82MP0009745_abnormal_behavioral_response0.85592382
83MP0006036_abnormal_mitochondrial_physio0.85545359
84MP0005253_abnormal_eye_physiology0.84357103
85MP0010155_abnormal_intestine_physiology0.84285524
86MP0008932_abnormal_embryonic_tissue0.84192548
87MP0003646_muscle_fatigue0.80638669
88MP0003787_abnormal_imprinting0.79155015
89MP0002006_tumorigenesis0.78519423
90MP0009333_abnormal_splenocyte_physiolog0.78303531
91MP0008875_abnormal_xenobiotic_pharmacok0.78125529
92MP0005646_abnormal_pituitary_gland0.78051902
93MP0000371_diluted_coat_color0.76767219
94MP0005379_endocrine/exocrine_gland_phen0.76725492
95MP0001944_abnormal_pancreas_morphology0.76712822
96MP0002272_abnormal_nervous_system0.76493021
97MP0005389_reproductive_system_phenotype0.73549922
98MP0002136_abnormal_kidney_physiology0.73259370
99MP0002736_abnormal_nociception_after0.72364163
100MP0003866_abnormal_defecation0.71622969
101MP0000015_abnormal_ear_pigmentation0.67276745
102MP0003195_calcinosis0.66682366
103MP0000613_abnormal_salivary_gland0.65363342
104MP0001984_abnormal_olfaction0.65141425
105MP0003045_fibrosis0.64621125
106MP0005167_abnormal_blood-brain_barrier0.64556629
107MP0003786_premature_aging0.63675392
108MP0003300_gastrointestinal_ulcer0.62978765
109MP0001346_abnormal_lacrimal_gland0.62720326
110MP0003121_genomic_imprinting0.61385868
111MP0000490_abnormal_crypts_of0.60819100
112MP0005464_abnormal_platelet_physiology0.60219059
113MP0003011_delayed_dark_adaptation0.60210199
114MP0005332_abnormal_amino_acid0.59062298
115MP0003984_embryonic_growth_retardation0.57780381
116MP0001529_abnormal_vocalization0.57077597
117MP0008469_abnormal_protein_level0.57048676
118MP0005380_embryogenesis_phenotype0.55584587
119MP0001672_abnormal_embryogenesis/_devel0.55584587
120MP0008877_abnormal_DNA_methylation0.55415938
121MP0002088_abnormal_embryonic_growth/wei0.54163188
122MP0005023_abnormal_wound_healing0.53641654
123MP0010307_abnormal_tumor_latency0.52989327
124MP0009697_abnormal_copulation0.52405817
125MP0005584_abnormal_enzyme/coenzyme_acti0.51864447
126* MP0002083_premature_death0.50938264
127MP0005621_abnormal_cell_physiology0.50842206
128MP0002095_abnormal_skin_pigmentation0.50483989
129* MP0001191_abnormal_skin_condition0.50381004
130MP0001697_abnormal_embryo_size0.49298643
131MP0006035_abnormal_mitochondrial_morpho0.48892767
132MP0002080_prenatal_lethality0.48798775
133MP0009764_decreased_sensitivity_to0.48482668
134MP0002132_abnormal_respiratory_system0.47527756
135MP0010234_abnormal_vibrissa_follicle0.46171025
136MP0005075_abnormal_melanosome_morpholog0.44608136
137MP0005384_cellular_phenotype0.43648822
138MP0001919_abnormal_reproductive_system0.43393480
139MP0000858_altered_metastatic_potential0.42885637
140MP0005257_abnormal_intraocular_pressure0.42045156
141MP0005266_abnormal_metabolism0.41392047
142MP0005394_taste/olfaction_phenotype0.40496698
143MP0005499_abnormal_olfactory_system0.40496698

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.69470815
2Gastrointestinal stroma tumor (HP:0100723)8.69752223
3Recurrent sinusitis (HP:0011108)7.54754780
4Recurrent bronchitis (HP:0002837)6.98832769
5Cellulitis (HP:0100658)6.13002904
6Abnormality of cells of the lymphoid lineage (HP:0012140)5.59956390
7Lymphopenia (HP:0001888)5.50383729
8Chronic sinusitis (HP:0011109)5.39967976
9Recurrent pneumonia (HP:0006532)5.37625751
10Abnormal delayed hypersensitivity skin test (HP:0002963)5.07832206
11Autoimmune thrombocytopenia (HP:0001973)4.90555480
12Emphysema (HP:0002097)4.86448102
13* Recurrent lower respiratory tract infections (HP:0002783)4.65344272
14Verrucae (HP:0200043)4.63132770
15Papilloma (HP:0012740)4.63132770
16Vasculitis (HP:0002633)4.47209491
17IgM deficiency (HP:0002850)4.39662772
18Bronchitis (HP:0012387)4.30064282
19Colitis (HP:0002583)4.26205041
20Meningitis (HP:0001287)4.20973920
21Recurrent viral infections (HP:0004429)3.86286509
22Osteomyelitis (HP:0002754)3.85092001
23Recurrent otitis media (HP:0000403)3.79797460
24Panhypogammaglobulinemia (HP:0003139)3.78408594
25Restrictive lung disease (HP:0002091)3.74031030
26Inflammation of the large intestine (HP:0002037)3.54547344
27Abnormality of T cell physiology (HP:0011840)3.51659759
28Leukopenia (HP:0001882)3.42589433
29Gastrointestinal inflammation (HP:0004386)3.38751634
30Chronic otitis media (HP:0000389)3.34515378
31Multiple enchondromatosis (HP:0005701)3.22542828
32Lymphoma (HP:0002665)3.14551030
33B lymphocytopenia (HP:0010976)3.11765039
34Abnormality of B cell number (HP:0010975)3.11765039
35Sepsis (HP:0100806)3.08472824
36* IgG deficiency (HP:0004315)2.99191609
37Chronic diarrhea (HP:0002028)2.97778136
38Pancreatic cysts (HP:0001737)2.94569518
39Chronic mucocutaneous candidiasis (HP:0002728)2.93966456
40Recurrent cutaneous fungal infections (HP:0011370)2.93966456
41Thyroiditis (HP:0100646)2.87464330
42Pendular nystagmus (HP:0012043)2.81627102
43Chronic hepatic failure (HP:0100626)2.78015202
44Recurrent abscess formation (HP:0002722)2.77789646
45Skin rash (HP:0000988)2.76173384
46Small epiphyses (HP:0010585)2.72196210
47Abnormality of T cells (HP:0002843)2.71063093
48Viral hepatitis (HP:0006562)2.69831244
49Recurrent fungal infections (HP:0002841)2.69469487
50Limb hypertonia (HP:0002509)2.66716627
51Molar tooth sign on MRI (HP:0002419)2.66459500
52Abnormality of midbrain morphology (HP:0002418)2.66459500
53Chromsome breakage (HP:0040012)2.64483715
54Recurrent bacterial skin infections (HP:0005406)2.62534170
55Congenital stationary night blindness (HP:0007642)2.61595394
56Increased IgM level (HP:0003496)2.60360551
57Hypochromic anemia (HP:0001931)2.60091226
58Autoimmune hemolytic anemia (HP:0001890)2.55133714
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52068298
60Combined immunodeficiency (HP:0005387)2.50465705
61True hermaphroditism (HP:0010459)2.48132869
62Squamous cell carcinoma (HP:0002860)2.47619598
63Attenuation of retinal blood vessels (HP:0007843)2.40660851
643-Methylglutaconic aciduria (HP:0003535)2.35969077
65Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35812927
66Abnormality of the renal collecting system (HP:0004742)2.35803813
67Eosinophilia (HP:0001880)2.35300466
68Pancreatic fibrosis (HP:0100732)2.35248889
69Nasal polyposis (HP:0100582)2.34745713
70Encephalitis (HP:0002383)2.34055136
71Abnormality of the renal cortex (HP:0011035)2.31948142
72Abnormal lung lobation (HP:0002101)2.31284890
73Type II lissencephaly (HP:0007260)2.29040287
74Recurrent skin infections (HP:0001581)2.25874160
75Abnormality of T cell number (HP:0011839)2.25530572
76Neutropenia (HP:0001875)2.25405800
77Nephronophthisis (HP:0000090)2.24710745
78Abnormal pancreas size (HP:0012094)2.24055781
79Carpal bone hypoplasia (HP:0001498)2.23554630
80Abnormality of DNA repair (HP:0003254)2.23510700
81Duplicated collecting system (HP:0000081)2.19181939
82Basal cell carcinoma (HP:0002671)2.16669589
83Mediastinal lymphadenopathy (HP:0100721)2.15668343
84Conical tooth (HP:0000698)2.15396141
85Pulmonary infiltrates (HP:0002113)2.14657875
86Birth length less than 3rd percentile (HP:0003561)2.12662077
87Abnormal rod and cone electroretinograms (HP:0008323)2.11798817
88Hypoplasia of the uterus (HP:0000013)2.11796354
89Aplasia/hypoplasia of the uterus (HP:0008684)2.10488571
90Hypothermia (HP:0002045)2.09976674
91Renal cortical cysts (HP:0000803)2.07795823
92Inability to walk (HP:0002540)2.06632869
93Bronchiectasis (HP:0002110)2.06104206
94Hypoplasia of the pons (HP:0012110)2.05849343
95Eczematoid dermatitis (HP:0000976)2.05754639
96Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05169717
97Abnormality of the pons (HP:0007361)2.03598290
98Methylmalonic acidemia (HP:0002912)2.03172430
99Abnormality of small intestinal villus morphology (HP:0011472)2.02189572
100Villous atrophy (HP:0011473)2.02189572
101Tubular atrophy (HP:0000092)2.01063690
102Granulocytopenia (HP:0001913)2.00144342
103* IgA deficiency (HP:0002720)1.99031224
104Abnormality of chromosome stability (HP:0003220)1.97915090
105Asplenia (HP:0001746)1.96750955
106Lissencephaly (HP:0001339)1.96521144
107Abnormality of the preputium (HP:0100587)1.96470468
108Increased corneal curvature (HP:0100692)1.96389063
109Keratoconus (HP:0000563)1.96389063
110Paralysis (HP:0003470)1.96065422
111Abnormality of the fingertips (HP:0001211)1.95957429
112Methylmalonic aciduria (HP:0012120)1.95639583
113Aplasia/Hypoplasia of the spleen (HP:0010451)1.94242765
114Progressive inability to walk (HP:0002505)1.92909069
115Elevated erythrocyte sedimentation rate (HP:0003565)1.91655402
116Skin ulcer (HP:0200042)1.91601700
117Aplasia/Hypoplasia of the uvula (HP:0010293)1.91374661
118Abnormality of male internal genitalia (HP:0000022)1.91368964
119Aplasia/Hypoplasia of the thymus (HP:0010515)1.90565651
120Lipid accumulation in hepatocytes (HP:0006561)1.90073262
121Abolished electroretinogram (ERG) (HP:0000550)1.87776174
122Abnormality of the carotid arteries (HP:0005344)1.86961758
123Arthralgia (HP:0002829)1.86607845
124Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85427459
125Absent epiphyses (HP:0010577)1.85427459
126Myelodysplasia (HP:0002863)1.84583058
127Abnormality of the renal medulla (HP:0100957)1.84176370
128Nephroblastoma (Wilms tumor) (HP:0002667)1.83727268
129Meckel diverticulum (HP:0002245)1.83558570
130Absent thumb (HP:0009777)1.83129091
131Chronic obstructive pulmonary disease (HP:0006510)1.82631952
132Obstructive lung disease (HP:0006536)1.82631952
133Gaze-evoked nystagmus (HP:0000640)1.82017288
134Recurrent gram-negative bacterial infections (HP:0005420)1.80465517
135Increased CSF lactate (HP:0002490)1.79234785
136Hypergammaglobulinemia (HP:0010702)1.77549245
137Mitochondrial inheritance (HP:0001427)1.75151403
138Abnormality of the prostate (HP:0008775)1.75063609
139Sloping forehead (HP:0000340)1.75044125
140Hyperglycinuria (HP:0003108)1.75025758
141Abnormality of the ileum (HP:0001549)1.74496214
142Increased IgE level (HP:0003212)1.73922519
143Small intestinal stenosis (HP:0012848)1.73077293
144Duodenal stenosis (HP:0100867)1.73077293
145Volvulus (HP:0002580)1.72469860
146Abnormality of the nasal mucosa (HP:0000433)1.72459777
147Papilledema (HP:0001085)1.71096596
148Progressive cerebellar ataxia (HP:0002073)1.70535489
149Embryonal renal neoplasm (HP:0011794)1.69489737
150Increased nuchal translucency (HP:0010880)1.68961525
151Abnormality of eosinophils (HP:0001879)1.68722623
152Abnormal number of erythroid precursors (HP:0012131)1.66951605
153Clubbing of toes (HP:0100760)1.66390548
154Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.65000072
155Hyperalaninemia (HP:0003348)1.63798289
156Leukocytosis (HP:0001974)1.61043431

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.67662453
2BLK4.11448583
3CSF1R3.94904191
4SYK3.60475283
5ERN13.57019363
6FRK3.12826454
7GRK63.04189943
8BUB13.00754179
9CDC72.91162471
10TAOK32.86563975
11ZAK2.86484227
12CDK122.63423507
13BTK2.28398323
14KIT2.23558696
15LYN2.23214705
16STK102.12081292
17CCNB11.93635040
18TAF11.89418028
19BMPR1B1.89162943
20GRK11.86705016
21MST41.74165867
22NUAK11.74080886
23RIPK41.71197009
24NEK91.67054766
25PASK1.64254841
26CLK11.58238379
27BCKDK1.56232279
28NEK21.50857362
29EIF2AK31.49886973
30BCR1.44117276
31MAP4K21.39945000
32ITK1.36817670
33EIF2AK11.35951903
34MAP3K141.35902539
35EPHA31.34835563
36MAP3K101.32247859
37TEC1.25978417
38BRSK11.19332046
39GRK51.15588627
40LRRK21.13714470
41STK38L1.05376806
42PRPF4B1.05044723
43STK241.01671909
44PIM11.01450564
45MAPK70.99622730
46IKBKB0.99134504
47BMPR20.95898964
48MAPK110.95232370
49TBK10.94143115
50RPS6KA50.94134713
51MATK0.92524354
52SIK30.91940500
53TESK20.91535044
54MAP3K40.91438670
55CSK0.91005127
56LCK0.90174015
57CHEK20.89951040
58TNIK0.88542494
59ALK0.88272163
60HCK0.87332693
61ACVR1B0.87236372
62TTK0.86905247
63ATR0.85707441
64ZAP700.83779840
65PLK10.81811269
66MKNK20.80854093
67CSNK1G30.79031598
68WNK30.78942283
69MAPK130.78106408
70CHEK10.77538578
71PTK2B0.77307401
72TGFBR10.77204167
73TGFBR20.76814604
74OXSR10.75298723
75FGFR30.74353234
76AURKB0.73644162
77JAK30.73375998
78ADRBK20.72870139
79IRAK40.72590939
80CSNK1A1L0.72545341
81PLK40.71124096
82BRSK20.71075038
83CDC42BPA0.70965090
84* PRKCQ0.70101034
85CSNK1G10.68921853
86RPS6KA40.68808242
87VRK20.68560699
88EIF2AK20.68329878
89WEE10.64560105
90TXK0.64435003
91INSRR0.64286635
92MAPKAPK30.64243439
93SRPK10.63100229
94PKN10.61978739
95FES0.59719598
96MAP3K130.58985289
97MAPKAPK50.58309588
98TYK20.58127512
99NME10.57287105
100PIM20.57194659
101CDK40.56766210
102CDK190.56483890
103* PRKCD0.55685696
104MAPK120.55273308
105MELK0.54036427
106CDK70.51876207
107VRK10.50266382
108MAP2K70.47930036
109STK30.47814819
110INSR0.47295534
111HIPK20.45551472
112IRAK10.45427937
113AURKA0.43851045
114MAP3K90.43769151
115DAPK30.41807416
116DAPK20.40910835
117STK40.40145071
118SIK20.40111268
119IKBKE0.39860116
120MARK30.39789257
121BRD40.39454337
122ABL10.38355520
123CSNK1G20.38336329
124FYN0.37837807
125MAPKAPK20.37689293
126ATM0.37128609
127SMG10.36633526
128MAP2K20.36507407
129CDK20.36481417
130JAK10.35779303
131SGK20.33621664
132CSNK2A10.32772458
133CHUK0.32473737
134PDK10.31370469
135CSNK1A10.29478081
136CSNK1D0.29322917
137TNK20.29194410
138CDK90.29041014
139PAK30.27063879
140CDK80.25716064
141CSNK2A20.25491278
142IGF1R0.25442093
143NEK10.24200600
144CDK10.23297160
145DYRK1A0.22354883
146GRK70.21289632
147TLK10.18971707

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053405.71306269
2DNA replication_Homo sapiens_hsa030304.93616589
3Mismatch repair_Homo sapiens_hsa034304.80515043
4Base excision repair_Homo sapiens_hsa034104.70776716
5B cell receptor signaling pathway_Homo sapiens_hsa046624.34847913
6Homologous recombination_Homo sapiens_hsa034402.96159972
7Systemic lupus erythematosus_Homo sapiens_hsa053222.61265650
8Nucleotide excision repair_Homo sapiens_hsa034202.56605100
9* Intestinal immune network for IgA production_Homo sapiens_hsa046722.43029847
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.34782181
11Proteasome_Homo sapiens_hsa030502.17371374
12Fanconi anemia pathway_Homo sapiens_hsa034602.07679430
13Antigen processing and presentation_Homo sapiens_hsa046121.98099374
14Non-homologous end-joining_Homo sapiens_hsa034501.94410065
15Ribosome_Homo sapiens_hsa030101.86893567
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81783876
17Cell cycle_Homo sapiens_hsa041101.68148159
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68053125
19Spliceosome_Homo sapiens_hsa030401.67774600
20Selenocompound metabolism_Homo sapiens_hsa004501.66220258
21Hematopoietic cell lineage_Homo sapiens_hsa046401.59777622
22Pyrimidine metabolism_Homo sapiens_hsa002401.49308224
23Herpes simplex infection_Homo sapiens_hsa051681.37732935
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34898141
25Phototransduction_Homo sapiens_hsa047441.33199818
26Allograft rejection_Homo sapiens_hsa053301.31776470
27RNA polymerase_Homo sapiens_hsa030201.28146800
28RNA transport_Homo sapiens_hsa030131.27590374
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25286379
30Rheumatoid arthritis_Homo sapiens_hsa053231.21429809
31Staphylococcus aureus infection_Homo sapiens_hsa051501.20606909
32p53 signaling pathway_Homo sapiens_hsa041151.17568989
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.17017649
34One carbon pool by folate_Homo sapiens_hsa006701.13180361
35Type I diabetes mellitus_Homo sapiens_hsa049401.10738684
36Asthma_Homo sapiens_hsa053101.10261284
37Graft-versus-host disease_Homo sapiens_hsa053321.09773601
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08857695
39Shigellosis_Homo sapiens_hsa051311.04983378
40Viral myocarditis_Homo sapiens_hsa054161.03156953
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01202013
42Leishmaniasis_Homo sapiens_hsa051400.98096225
43Epstein-Barr virus infection_Homo sapiens_hsa051690.97551812
44RNA degradation_Homo sapiens_hsa030180.97120269
45Alcoholism_Homo sapiens_hsa050340.95910746
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95575124
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95104363
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94050206
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92631672
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91994217
51Autoimmune thyroid disease_Homo sapiens_hsa053200.91163086
52Osteoclast differentiation_Homo sapiens_hsa043800.89484495
53Pentose phosphate pathway_Homo sapiens_hsa000300.88259903
54Protein export_Homo sapiens_hsa030600.86812906
55Measles_Homo sapiens_hsa051620.84872498
56HTLV-I infection_Homo sapiens_hsa051660.83928918
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83803348
58Basal transcription factors_Homo sapiens_hsa030220.83652312
59Apoptosis_Homo sapiens_hsa042100.83453676
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83030073
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82769755
62Tuberculosis_Homo sapiens_hsa051520.81209613
63Butanoate metabolism_Homo sapiens_hsa006500.79230588
64mRNA surveillance pathway_Homo sapiens_hsa030150.78836332
65T cell receptor signaling pathway_Homo sapiens_hsa046600.77689518
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77119708
67African trypanosomiasis_Homo sapiens_hsa051430.75445629
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74102072
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70154512
70Linoleic acid metabolism_Homo sapiens_hsa005910.69708569
71Hepatitis B_Homo sapiens_hsa051610.66752324
72Influenza A_Homo sapiens_hsa051640.64782822
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.64111914
74Oxidative phosphorylation_Homo sapiens_hsa001900.62832328
75Purine metabolism_Homo sapiens_hsa002300.61377318
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60131815
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58906494
78Viral carcinogenesis_Homo sapiens_hsa052030.57868624
79Parkinsons disease_Homo sapiens_hsa050120.54505368
80Vitamin B6 metabolism_Homo sapiens_hsa007500.52607641
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51588673
82Legionellosis_Homo sapiens_hsa051340.49874610
83Non-small cell lung cancer_Homo sapiens_hsa052230.49300861
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46859488
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46770878
86Sulfur relay system_Homo sapiens_hsa041220.46434119
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46337155
88Chemokine signaling pathway_Homo sapiens_hsa040620.41806987
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40936820
90Propanoate metabolism_Homo sapiens_hsa006400.40172916
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38958648
92Nitrogen metabolism_Homo sapiens_hsa009100.37580559
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36975001
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36560857
95Salmonella infection_Homo sapiens_hsa051320.36379341
96Ether lipid metabolism_Homo sapiens_hsa005650.35991540
97Pancreatic cancer_Homo sapiens_hsa052120.34383118
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.34165301
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33459115
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.33079560
101Nicotine addiction_Homo sapiens_hsa050330.32747207
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32322738
103Olfactory transduction_Homo sapiens_hsa047400.32203536
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30599328
105Caffeine metabolism_Homo sapiens_hsa002320.28134119
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.26519714
107TNF signaling pathway_Homo sapiens_hsa046680.26368875
108MicroRNAs in cancer_Homo sapiens_hsa052060.25893919
109Inositol phosphate metabolism_Homo sapiens_hsa005620.25462838
110Hepatitis C_Homo sapiens_hsa051600.25248461
111Oocyte meiosis_Homo sapiens_hsa041140.24576070
112Toxoplasmosis_Homo sapiens_hsa051450.23717224
113Fructose and mannose metabolism_Homo sapiens_hsa000510.23608398
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22996117
115Pertussis_Homo sapiens_hsa051330.22400331
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21934582
117Morphine addiction_Homo sapiens_hsa050320.20514763
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.18283065
119Huntingtons disease_Homo sapiens_hsa050160.18212906
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17524324
121Peroxisome_Homo sapiens_hsa041460.15520141
122Lysine degradation_Homo sapiens_hsa003100.15311965
123Platelet activation_Homo sapiens_hsa046110.15177555
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14936166
125Small cell lung cancer_Homo sapiens_hsa052220.14327084
126Glycerolipid metabolism_Homo sapiens_hsa005610.14189221
127Alzheimers disease_Homo sapiens_hsa050100.12270854
128ABC transporters_Homo sapiens_hsa020100.11826263
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10085145
130Malaria_Homo sapiens_hsa051440.09235903
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.08889776
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08689401
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.07573719
134Pathways in cancer_Homo sapiens_hsa052000.05508599
135MAPK signaling pathway_Homo sapiens_hsa040100.04990811
136Tryptophan metabolism_Homo sapiens_hsa003800.04376235
137Biosynthesis of amino acids_Homo sapiens_hsa012300.04080333
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.02867982
139Acute myeloid leukemia_Homo sapiens_hsa052210.02107724
140Colorectal cancer_Homo sapiens_hsa052100.01417569

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