AIDA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1iron ion import (GO:0097286)4.80655950
2negative regulation of glycogen biosynthetic process (GO:0045719)4.71588828
3Golgi transport vesicle coating (GO:0048200)4.16185679
4COPI coating of Golgi vesicle (GO:0048205)4.16185679
5negative regulation of glycogen metabolic process (GO:0070874)4.08373363
6positive regulation of interferon-alpha production (GO:0032727)4.04609490
7protein localization to endosome (GO:0036010)4.02911909
8regulation of early endosome to late endosome transport (GO:2000641)3.97891160
9import into cell (GO:0098657)3.90443892
10positive regulation by symbiont of host defense response (GO:0052509)3.81476495
11modulation by symbiont of host defense response (GO:0052031)3.81476495
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.81476495
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.81476495
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.81476495
15modulation by symbiont of host immune response (GO:0052553)3.81476495
16regulation of interferon-alpha production (GO:0032647)3.81199784
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.76472554
18cellular protein complex localization (GO:0034629)3.65956422
19cellular response to interferon-alpha (GO:0035457)3.65503427
20protein retention in ER lumen (GO:0006621)3.62642562
21nuclear pore complex assembly (GO:0051292)3.61213157
22paraxial mesoderm development (GO:0048339)3.59492583
23regulation of T-helper 1 cell differentiation (GO:0045625)3.55050839
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49091556
25response to type I interferon (GO:0034340)3.44241952
26cellular response to type I interferon (GO:0071357)3.41977641
27type I interferon signaling pathway (GO:0060337)3.41977641
28adherens junction assembly (GO:0034333)3.34029702
29regulation of glucose import in response to insulin stimulus (GO:2001273)3.33705566
30stress fiber assembly (GO:0043149)3.29161135
31cell-substrate junction assembly (GO:0007044)3.25624907
32vascular endothelial growth factor signaling pathway (GO:0038084)3.22644286
33chondrocyte proliferation (GO:0035988)3.20955134
34cell-substrate adherens junction assembly (GO:0007045)3.19825956
35focal adhesion assembly (GO:0048041)3.19825956
36insulin-like growth factor receptor signaling pathway (GO:0048009)3.19096687
37anterior/posterior axis specification, embryo (GO:0008595)3.18841023
38mitotic chromosome condensation (GO:0007076)3.15868238
39protein complex localization (GO:0031503)3.10959262
40hippo signaling (GO:0035329)3.09982234
41positive regulation of blood vessel endothelial cell migration (GO:0043536)3.02353508
42alpha-linolenic acid metabolic process (GO:0036109)3.00571041
43planar cell polarity pathway involved in neural tube closure (GO:0090179)2.98870868
44hypotonic response (GO:0006971)2.97212905
45positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.95413521
46mesodermal cell differentiation (GO:0048333)2.94781304
47nuclear pore organization (GO:0006999)2.94242270
48positive regulation of natural killer cell differentiation (GO:0032825)2.94137463
49positive regulation of monocyte chemotaxis (GO:0090026)2.94126279
50basement membrane organization (GO:0071711)2.93272052
51neutrophil activation involved in immune response (GO:0002283)2.92938958
52axon extension involved in axon guidance (GO:0048846)2.90365631
53neuron projection extension involved in neuron projection guidance (GO:1902284)2.90365631
54chondrocyte development (GO:0002063)2.90260423
55regulation of interferon-beta biosynthetic process (GO:0045357)2.88657910
56protein localization to microtubule (GO:0035372)2.87953611
57response to host immune response (GO:0052572)2.87628654
58response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.87628654
59COPII vesicle coating (GO:0048208)2.87234615
60interferon-gamma-mediated signaling pathway (GO:0060333)2.87148031
61endothelial cell morphogenesis (GO:0001886)2.86415053
62positive regulation of cellular response to insulin stimulus (GO:1900078)2.86198365
63cell adhesion mediated by integrin (GO:0033627)2.85986895
64response to interferon-alpha (GO:0035455)2.85672353
65regulation of monocyte chemotaxis (GO:0090025)2.83828402
66regulation of NFAT protein import into nucleus (GO:0051532)2.83738917
67maternal placenta development (GO:0001893)2.80967922
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.79940260
69negative regulation of viral genome replication (GO:0045071)2.78574228
70positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.78349988
71negative regulation of protein localization to plasma membrane (GO:1903077)2.77856362
72response to host (GO:0075136)2.75242169
73response to host defenses (GO:0052200)2.75242169
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.75242169
75vesicle coating (GO:0006901)2.74988922
76regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74119651
77regulation of integrin-mediated signaling pathway (GO:2001044)2.72073546
78natural killer cell mediated cytotoxicity (GO:0042267)2.71959770
79natural killer cell mediated immunity (GO:0002228)2.71959770
80vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.71741519
81hemidesmosome assembly (GO:0031581)2.69927859
82retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.69291256
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.65766080
84response to peptidoglycan (GO:0032494)2.65622107
85cellular response to virus (GO:0098586)2.65603660
86regulation of interleukin-12 biosynthetic process (GO:0045075)2.65078530
87regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64607009
88positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64432419
89positive regulation of interferon-beta production (GO:0032728)2.62457079
90positive regulation of endothelial cell apoptotic process (GO:2000353)2.61629186
91endocytic recycling (GO:0032456)2.60948190
92peptidyl-proline hydroxylation (GO:0019511)2.60872562
93embryonic process involved in female pregnancy (GO:0060136)2.60067766
94epithelial cell-cell adhesion (GO:0090136)2.59998117
95L-serine metabolic process (GO:0006563)2.55839846
96regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.53810227
97regulation of protein localization to plasma membrane (GO:1903076)2.53725899
98lipopolysaccharide-mediated signaling pathway (GO:0031663)2.52162627
99DNA unwinding involved in DNA replication (GO:0006268)2.52077855
100positive regulation of protein export from nucleus (GO:0046827)2.50749578
101negative regulation of anoikis (GO:2000811)2.49515567
102substrate-dependent cell migration (GO:0006929)2.49213529
103negative regulation of glucose import (GO:0046325)2.49088631
104regulation of protein export from nucleus (GO:0046825)2.47659127
105negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.47622431
106negative regulation of cell killing (GO:0031342)2.47622431
107regulation of dendritic cell antigen processing and presentation (GO:0002604)2.47078631
108T-helper 1 type immune response (GO:0042088)2.46867236
109regulation of nucleobase-containing compound transport (GO:0032239)2.46415262
110protein hydroxylation (GO:0018126)2.46034484
111regulation of RNA export from nucleus (GO:0046831)2.45432909
112retina vasculature morphogenesis in camera-type eye (GO:0061299)2.43364758
113wound healing, spreading of epidermal cells (GO:0035313)2.43047156
114mitotic sister chromatid cohesion (GO:0007064)2.42349895
115regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.42018935
116regulation of translational fidelity (GO:0006450)2.40806075
117collagen fibril organization (GO:0030199)2.40730672
118regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.40711806
119plasma membrane repair (GO:0001778)2.40117471
120positive regulation of interleukin-12 production (GO:0032735)2.39543090
121pore complex assembly (GO:0046931)2.38995850
122regulation of interferon-gamma biosynthetic process (GO:0045072)2.38483772
123macrophage activation involved in immune response (GO:0002281)2.37926460
124desmosome organization (GO:0002934)2.37466401
125cortical actin cytoskeleton organization (GO:0030866)2.37142105
126cell migration involved in sprouting angiogenesis (GO:0002042)2.37101135
127positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.36827324
128cellular response to vitamin (GO:0071295)2.36140060
129regulation of tight junction assembly (GO:2000810)2.35468920
130regulation of establishment of protein localization to plasma membrane (GO:0090003)2.35331614
131histone H2B ubiquitination (GO:0033523)2.34021058
132regulation of T-helper 2 cell differentiation (GO:0045628)2.33675847
133negative regulation of focal adhesion assembly (GO:0051895)2.33555495
134negative regulation of cell junction assembly (GO:1901889)2.33555495
135negative regulation of adherens junction organization (GO:1903392)2.33555495
136negative regulation of vascular permeability (GO:0043116)2.32686759
137notochord development (GO:0030903)2.32469131
138protein export from nucleus (GO:0006611)2.32338611
139regulation of chemokine-mediated signaling pathway (GO:0070099)2.31304095
140positive regulation of receptor recycling (GO:0001921)2.31090815
141beta-amyloid metabolic process (GO:0050435)2.31067697
142regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.30581404
143ER-nucleus signaling pathway (GO:0006984)2.29929323
144nucleotide-sugar biosynthetic process (GO:0009226)2.28116740
145positive regulation of chemokine biosynthetic process (GO:0045080)2.27913842
146ER overload response (GO:0006983)2.27154213
147activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.26661460
148immunoglobulin mediated immune response (GO:0016064)2.26323916
149granulocyte activation (GO:0036230)2.26226200
150NLS-bearing protein import into nucleus (GO:0006607)2.25826390
151regulation of endothelial cell chemotaxis (GO:2001026)2.25795998
152ganglion development (GO:0061548)2.25412793
153positive regulation of cAMP-mediated signaling (GO:0043950)2.25124659
154endoplasmic reticulum unfolded protein response (GO:0030968)2.25113383
155regulation of homotypic cell-cell adhesion (GO:0034110)2.24489852
156cellular response to interferon-gamma (GO:0071346)2.23052844
157cellular response to exogenous dsRNA (GO:0071360)2.22650755
158antigen processing and presentation of endogenous antigen (GO:0019883)2.22451834
159regulation of RIG-I signaling pathway (GO:0039535)2.21966958
160microglial cell activation (GO:0001774)2.21962207
161response to muramyl dipeptide (GO:0032495)2.21372892
162regulation of mononuclear cell migration (GO:0071675)2.18236149
163cortical cytoskeleton organization (GO:0030865)2.17124120
164sequestering of extracellular ligand from receptor (GO:0035581)2.17021135
165neutrophil activation (GO:0042119)2.16705397
166respiratory burst (GO:0045730)2.15242033
167cellular response to vitamin D (GO:0071305)2.15167166
168negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.13554829
169negative regulation of T-helper cell differentiation (GO:0045623)2.13554829
170protein heterotrimerization (GO:0070208)2.12766629
171regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.12390134
172I-kappaB phosphorylation (GO:0007252)2.12279025
173antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.11705276
174antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.11705276
175positive regulation of macrophage cytokine production (GO:0060907)2.11349258
176modulation by symbiont of host cellular process (GO:0044068)2.09760391
177eosinophil chemotaxis (GO:0048245)2.06358253
178regulation of protein heterodimerization activity (GO:0043497)2.03532410
179regulation of macrophage cytokine production (GO:0010935)2.03264309
180skin morphogenesis (GO:0043589)2.03059156
181regulation of histone phosphorylation (GO:0033127)2.02604975
182positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.01741136
183regulation of alpha-beta T cell proliferation (GO:0046640)2.00430351
184regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.00185572
185cellular response to nicotine (GO:0071316)1.99843419
186Rap protein signal transduction (GO:0032486)1.97878905
187endodermal cell differentiation (GO:0035987)1.97754914
188regulation of T-helper 1 type immune response (GO:0002825)1.97536284
189negative regulation of fatty acid transport (GO:2000192)1.95205679
190monocyte chemotaxis (GO:0002548)1.94393349
191positive regulation of defense response to virus by host (GO:0002230)1.94101072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.59363075
2AR_21909140_ChIP-Seq_LNCAP_Human4.42709965
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.33205900
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.22298820
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.54945965
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.36815770
7CLOCK_20551151_ChIP-Seq_293T_Human3.13385048
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.99011543
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.81167351
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.66147933
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.65768509
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.49556448
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.44198365
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.43450765
15KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.36338140
16ZNF263_19887448_ChIP-Seq_K562_Human2.31109404
17SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.24714505
18E2F7_22180533_ChIP-Seq_HELA_Human2.22223790
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20579003
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.20196430
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.20179636
22CHD1_26751641_Chip-Seq_LNCaP_Human2.18288183
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15083517
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14131267
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11811182
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07299540
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.97374437
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.94834908
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.94834908
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.94834908
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.92722627
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.91371568
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89400243
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86257190
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83406293
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.82279916
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79704858
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79141415
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.77394388
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76973192
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.75278899
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.74899582
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73460223
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.66586866
45TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.66193525
46TP53_18474530_ChIP-ChIP_U2OS_Human1.62013597
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61906410
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.61518333
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60122635
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.60038567
51CJUN_26792858_Chip-Seq_BT549_Human1.59795964
52TP53_16413492_ChIP-PET_HCT116_Human1.58626738
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58320527
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58213158
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57573201
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.55553733
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54855010
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54855010
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54721634
60BRD4_25478319_ChIP-Seq_HGPS_Human1.52137498
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.51670749
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50566622
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48567041
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48133248
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48024877
66RACK7_27058665_Chip-Seq_MCF-7_Human1.47809821
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.45350844
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44808530
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42051163
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.41968725
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41771600
72EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.41555376
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40547882
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.39792496
75ATF3_27146783_Chip-Seq_COLON_Human1.39488145
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39396931
77MYC_22102868_ChIP-Seq_BL_Human1.38859589
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37868130
79BP1_19119308_ChIP-ChIP_Hs578T_Human1.36768431
80VDR_24787735_ChIP-Seq_THP-1_Human1.35986116
81MYC_18555785_ChIP-Seq_MESCs_Mouse1.30422371
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30406647
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30208793
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30190713
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29103823
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29083776
87IGF1R_20145208_ChIP-Seq_DFB_Human1.28941561
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27591587
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.25758373
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25466419
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24455195
92* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23882821
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23754932
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23533531
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22482058
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21646859
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20071201
98TCF7_22412390_ChIP-Seq_EML_Mouse1.19260809
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18597554
100* KDM2B_26808549_Chip-Seq_K562_Human1.18222198
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17882750
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17549805
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17137860
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16992925
105TFEB_21752829_ChIP-Seq_HELA_Human1.15860356
106MYB_26560356_Chip-Seq_TH2_Human1.14288232
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14285086
108CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14223832
109SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13613297
110PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13484788
111NANOG_21062744_ChIP-ChIP_HESCs_Human1.13312324
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11709722
113EP300_21415370_ChIP-Seq_HL-1_Mouse1.11601088
114TAF15_26573619_Chip-Seq_HEK293_Human1.11533278
115SPI1_23127762_ChIP-Seq_K562_Human1.11365960
116RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10990260
117SOX2_20726797_ChIP-Seq_SW620_Human1.10959650
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09938590
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09573911
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08362220
121AR_21572438_ChIP-Seq_LNCaP_Human1.08270116
122JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08122387
123RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07473380
124EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07473380
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07435637
126JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06794528
127GATA4_21415370_ChIP-Seq_HL-1_Mouse1.06794112
128ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05957920
129POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05897158
130SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05354649
131SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05354649
132ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05111505
133RUNX_20019798_ChIP-Seq_JUKART_Human1.05027823
134NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04584751
135SOX17_20123909_ChIP-Seq_XEN_Mouse1.04508967
136PU_27001747_Chip-Seq_BMDM_Mouse1.03548645
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03539813
138DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02894553
139NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02646833
140GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02576060
141EED_16625203_ChIP-ChIP_MESCs_Mouse1.02134902
142FOXO3_23340844_ChIP-Seq_DLD1_Human1.02088141
143FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01570993
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01355258
145SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00621388
146CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00262926
147TBX20_22328084_ChIP-Seq_HEART_Mouse0.99830330
148TBX20_22080862_ChIP-Seq_HEART_Mouse0.99830330
149NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99543697
150SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98553603
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98200511
152* KDM2B_26808549_Chip-Seq_JURKAT_Human0.97508655
153UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97202719
154SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96872223
155FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95464357
156PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95079788
157VDR_24763502_ChIP-Seq_THP-1_Human0.93458780
158CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92308134
159PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92057939
160ER_23166858_ChIP-Seq_MCF-7_Human0.91587521
161P300_19829295_ChIP-Seq_ESCs_Human0.91529971
162UBF1/2_26484160_Chip-Seq_HMECs_Human0.89368519
163MAF_26560356_Chip-Seq_TH1_Human0.89132571
164PIAS1_25552417_ChIP-Seq_VCAP_Human0.88351617
165HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88219995
166TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86899317
167MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86848817
168* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85734983
169KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85068548
170FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84290081
171SMAD4_21799915_ChIP-Seq_A2780_Human0.83600335
172TP63_17297297_ChIP-ChIP_HaCaT_Human0.83574384
173ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83070816
174JUN_21703547_ChIP-Seq_K562_Human0.82720767
175TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80686275
176SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80583736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.36440438
2MP0003941_abnormal_skin_development2.88729171
3MP0005623_abnormal_meninges_morphology2.74356355
4MP0005503_abnormal_tendon_morphology2.52358392
5MP0010234_abnormal_vibrissa_follicle2.51386841
6MP0004233_abnormal_muscle_weight2.48125997
7MP0003303_peritoneal_inflammation2.41858733
8MP0001835_abnormal_antigen_presentation2.32603612
9MP0005451_abnormal_body_composition2.31931099
10MP0004510_myositis2.30136482
11MP0003705_abnormal_hypodermis_morpholog2.29879672
12MP0005275_abnormal_skin_tensile2.21507580
13MP0002009_preneoplasia2.04770341
14MP0001958_emphysema2.01876944
15MP0000537_abnormal_urethra_morphology2.00318219
16MP0003091_abnormal_cell_migration1.99868873
17MP0005387_immune_system_phenotype1.94406947
18MP0001790_abnormal_immune_system1.94406947
19MP0006054_spinal_hemorrhage1.93610075
20MP0001348_abnormal_lacrimal_gland1.91917802
21MP0005257_abnormal_intraocular_pressure1.89044621
22MP0003279_aneurysm1.87647682
23MP0000569_abnormal_digit_pigmentation1.85874540
24MP0005000_abnormal_immune_tolerance1.80234702
25MP0002148_abnormal_hypersensitivity_rea1.77316332
26MP0005409_darkened_coat_color1.76703937
27MP0009785_altered_susceptibility_to1.73427025
28MP0003453_abnormal_keratinocyte_physiol1.72998991
29MP0004272_abnormal_basement_membrane1.69142222
30MP0005666_abnormal_adipose_tissue1.66829480
31MP0001849_ear_inflammation1.65838151
32MP0002060_abnormal_skin_morphology1.64126230
33MP0000733_abnormal_muscle_development1.63235137
34MP0000685_abnormal_immune_system1.61395492
35MP0003436_decreased_susceptibility_to1.60686151
36MP0001879_abnormal_lymphatic_vessel1.54930684
37MP0009053_abnormal_anal_canal1.52650317
38MP0001730_embryonic_growth_arrest1.49821552
39MP0005023_abnormal_wound_healing1.49427464
40MP0003448_altered_tumor_morphology1.48697216
41MP0003122_maternal_imprinting1.48473241
42MP0002796_impaired_skin_barrier1.48022016
43MP0000767_abnormal_smooth_muscle1.47931950
44MP0006082_CNS_inflammation1.47866164
45MP0003045_fibrosis1.45398931
46MP0010386_abnormal_urinary_bladder1.45074939
47MP0002877_abnormal_melanocyte_morpholog1.44788915
48MP0002452_abnormal_antigen_presenting1.42125568
49MP0005076_abnormal_cell_differentiation1.37188305
50MP0003385_abnormal_body_wall1.36273890
51MP0001299_abnormal_eye_distance/1.35740910
52MP0002998_abnormal_bone_remodeling1.34506275
53MP0002006_tumorigenesis1.31307904
54MP0010352_gastrointestinal_tract_polyps1.27013200
55MP0005671_abnormal_response_to1.24835687
56MP0002419_abnormal_innate_immunity1.22838835
57MP0004957_abnormal_blastocyst_morpholog1.22413483
58MP0003566_abnormal_cell_adhesion1.22149559
59MP0000013_abnormal_adipose_tissue1.21806633
60MP0001800_abnormal_humoral_immune1.21360283
61MP0005025_abnormal_response_to1.20015765
62MP0001533_abnormal_skeleton_physiology1.19020080
63MP0002086_abnormal_extraembryonic_tissu1.17953704
64MP0002723_abnormal_immune_serum1.16879091
65MP0005375_adipose_tissue_phenotype1.16831292
66MP0009250_abnormal_appendicular_skeleto1.15565585
67MP0009384_cardiac_valve_regurgitation1.15271815
68MP0001819_abnormal_immune_cell1.14800695
69MP0003950_abnormal_plasma_membrane1.12691350
70MP0003984_embryonic_growth_retardation1.11714995
71MP0000350_abnormal_cell_proliferation1.10033893
72MP0001672_abnormal_embryogenesis/_devel1.09733781
73MP0005380_embryogenesis_phenotype1.09733781
74MP0005508_abnormal_skeleton_morphology1.09613186
75MP0002420_abnormal_adaptive_immunity1.09324012
76MP0005390_skeleton_phenotype1.06780861
77MP0002088_abnormal_embryonic_growth/wei1.06655727
78MP0005621_abnormal_cell_physiology1.06331288
79MP0004808_abnormal_hematopoietic_stem1.06304297
80MP0003724_increased_susceptibility_to1.05818648
81MP0002166_altered_tumor_susceptibility1.04581337
82MP0002084_abnormal_developmental_patter1.03194728
83MP0005501_abnormal_skin_physiology1.02138780
84MP0009672_abnormal_birth_weight1.01230180
85MP0010307_abnormal_tumor_latency1.00944919
86MP0003890_abnormal_embryonic-extraembry1.00038562
87MP0000627_abnormal_mammary_gland0.99338644
88MP0008057_abnormal_DNA_replication0.99243180
89MP0006138_congestive_heart_failure0.97640436
90MP0002925_abnormal_cardiovascular_devel0.96830483
91MP0002896_abnormal_bone_mineralization0.96151877
92MP0003300_gastrointestinal_ulcer0.96061835
93MP0002163_abnormal_gland_morphology0.95866566
94MP0001542_abnormal_bone_strength0.94936252
95MP0002085_abnormal_embryonic_tissue0.94034896
96MP0005167_abnormal_blood-brain_barrier0.93618116
97MP0003828_pulmonary_edema0.92799798
98MP0002080_prenatal_lethality0.92795648
99MP0009278_abnormal_bone_marrow0.92216217
100MP0005645_abnormal_hypothalamus_physiol0.91835707
101MP0009333_abnormal_splenocyte_physiolog0.90797162
102MP0002933_joint_inflammation0.90757936
103MP0001697_abnormal_embryo_size0.90414157
104MP0000432_abnormal_head_morphology0.89270719
105MP0002102_abnormal_ear_morphology0.87643441
106MP0008260_abnormal_autophagy0.87401468
107MP0000762_abnormal_tongue_morphology0.87066428
108MP0004197_abnormal_fetal_growth/weight/0.86914930
109MP0001216_abnormal_epidermal_layer0.85885903
110MP0003868_abnormal_feces_composition0.85709628
111MP0000534_abnormal_ureter_morphology0.84949649
112MP0005367_renal/urinary_system_phenotyp0.84376183
113MP0000516_abnormal_urinary_system0.84376183
114MP0000428_abnormal_craniofacial_morphol0.84281496
115MP0005171_absent_coat_pigmentation0.84119659
116MP0000858_altered_metastatic_potential0.82938029
117MP0001614_abnormal_blood_vessel0.81045554
118MP0003315_abnormal_perineum_morphology0.78667906
119MP0002168_other_aberrant_phenotype0.78570201
120MP0010630_abnormal_cardiac_muscle0.78072232
121MP0005384_cellular_phenotype0.77965057
122MP0003959_abnormal_lean_body0.77685499
123MP0008932_abnormal_embryonic_tissue0.77593656
124MP0003115_abnormal_respiratory_system0.77530733
125MP0002113_abnormal_skeleton_development0.76868987
126MP0002295_abnormal_pulmonary_circulatio0.76592973
127MP0002405_respiratory_system_inflammati0.76382758
128MP0005164_abnormal_response_to0.75058222
129MP0008004_abnormal_stomach_pH0.74565591
130MP0000372_irregular_coat_pigmentation0.73931469
131MP0005197_abnormal_uvea_morphology0.73884892
132MP0004858_abnormal_nervous_system0.73865381
133MP0009697_abnormal_copulation0.72994181
134MP0002697_abnormal_eye_size0.72627777
135MP0001881_abnormal_mammary_gland0.72613266
136MP0003123_paternal_imprinting0.72328000
137MP0000003_abnormal_adipose_tissue0.71822843
138MP0002115_abnormal_skeleton_extremities0.71115873
139MP0002398_abnormal_bone_marrow0.71010739
140MP0000747_muscle_weakness0.70949205
141MP0003111_abnormal_nucleus_morphology0.70825142
142MP0003795_abnormal_bone_structure0.70758347
143MP0000716_abnormal_immune_system0.70056318
144MP0000343_altered_response_to0.68388537
145MP0005058_abnormal_lysosome_morphology0.68296306
146MP0001915_intracranial_hemorrhage0.68165720
147MP0004947_skin_inflammation0.68091052
148MP0002128_abnormal_blood_circulation0.66889561
149MP0010368_abnormal_lymphatic_system0.65728904
150MP0001851_eye_inflammation0.63339820
151MP0002177_abnormal_outer_ear0.62758383
152MP0000249_abnormal_blood_vessel0.62197251
153MP0005310_abnormal_salivary_gland0.61728234
154MP0002133_abnormal_respiratory_system0.61106650
155MP0005388_respiratory_system_phenotype0.61106650
156MP0004185_abnormal_adipocyte_glucose0.59973112
157MP0003942_abnormal_urinary_system0.58934818
158MP0003283_abnormal_digestive_organ0.56462604
159MP0003121_genomic_imprinting0.55806210

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.12613618
2Premature rupture of membranes (HP:0001788)3.92042581
3Syringomyelia (HP:0003396)3.51623094
4Spinal cord lesions (HP:0100561)3.51623094
5Recurrent abscess formation (HP:0002722)3.42671262
6Recurrent bacterial skin infections (HP:0005406)2.98787652
7Ankyloglossia (HP:0010296)2.92217455
8Hematochezia (HP:0002573)2.88430514
9Obstructive sleep apnea (HP:0002870)2.88279511
10Cerebral aneurysm (HP:0004944)2.78412609
11Disinhibition (HP:0000734)2.76227954
12Shallow orbits (HP:0000586)2.75943833
13Sparse lateral eyebrow (HP:0005338)2.75719783
14Aortic dissection (HP:0002647)2.71748395
15Vertebral compression fractures (HP:0002953)2.61892966
16Neonatal hypoglycemia (HP:0001998)2.60975178
17Peritonitis (HP:0002586)2.58756920
18Soft skin (HP:0000977)2.51782162
19Eczematoid dermatitis (HP:0000976)2.50251895
20Dilatation of the ascending aorta (HP:0005111)2.50033928
21Wormian bones (HP:0002645)2.49678628
22Porencephaly (HP:0002132)2.49651653
23Absent frontal sinuses (HP:0002688)2.49198267
24Long palpebral fissure (HP:0000637)2.45661471
25Prostate neoplasm (HP:0100787)2.41624606
26Vertebral arch anomaly (HP:0008438)2.40095700
27Disproportionate tall stature (HP:0001519)2.37228580
28Buphthalmos (HP:0000557)2.35896995
29Chronic otitis media (HP:0000389)2.35405049
30Abnormality of oral frenula (HP:0000190)2.33176881
31Spondylolisthesis (HP:0003302)2.32334222
32Macroorchidism (HP:0000053)2.28258958
33Increased density of long bones (HP:0006392)2.25490421
34Asymmetry of the thorax (HP:0001555)2.25372878
35Osteolytic defects of the hand bones (HP:0009699)2.25188414
36Osteolytic defects of the phalanges of the hand (HP:0009771)2.25188414
37Vascular tortuosity (HP:0004948)2.23458164
38Mitral valve prolapse (HP:0001634)2.22557752
39Fragile skin (HP:0001030)2.22296719
40Aortic aneurysm (HP:0004942)2.21429274
41Genu recurvatum (HP:0002816)2.20966344
42Biconcave vertebral bodies (HP:0004586)2.19510661
43Obstructive lung disease (HP:0006536)2.15226181
44Chronic obstructive pulmonary disease (HP:0006510)2.15226181
45Wrist flexion contracture (HP:0001239)2.14431486
46Hyperacusis (HP:0010780)2.14313745
47Abnormality of dentin (HP:0010299)2.14230775
48Increased variability in muscle fiber diameter (HP:0003557)2.14195146
49Atrophic scars (HP:0001075)2.13658603
50Basal ganglia calcification (HP:0002135)2.12426261
51Bladder diverticulum (HP:0000015)2.12408074
52Enlarged penis (HP:0000040)2.10050205
53Termporal pattern (HP:0011008)2.09398068
54Insidious onset (HP:0003587)2.09398068
55Flat acetabular roof (HP:0003180)2.08212074
56Arterial tortuosity (HP:0005116)2.07654006
57Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.07413400
58Increased IgM level (HP:0003496)2.07292719
59Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03384674
60Papilledema (HP:0001085)2.03251643
61Abnormality of skeletal muscle fiber size (HP:0012084)2.01018983
62Advanced eruption of teeth (HP:0006288)2.00766195
63Subacute progressive viral hepatitis (HP:0006572)1.97874056
64Spinal cord compression (HP:0002176)1.96900666
65Joint laxity (HP:0001388)1.93634622
66Cervical subluxation (HP:0003308)1.93386214
67Spinal rigidity (HP:0003306)1.91758418
68Chronic sinusitis (HP:0011109)1.90803265
69Back pain (HP:0003418)1.90098722
70Inappropriate behavior (HP:0000719)1.89978238
71Mediastinal lymphadenopathy (HP:0100721)1.88761124
72Microglossia (HP:0000171)1.87949634
73Broad face (HP:0000283)1.86697631
74Viral hepatitis (HP:0006562)1.86550648
75Autoimmune thrombocytopenia (HP:0001973)1.85951225
76Cubitus valgus (HP:0002967)1.84822203
77Nuclear cataract (HP:0100018)1.83839559
78Follicular hyperkeratosis (HP:0007502)1.83621407
79Myositis (HP:0100614)1.83400759
80Aneurysm (HP:0002617)1.81787995
81Cerebral inclusion bodies (HP:0100314)1.79834922
82Increased cerebral lipofuscin (HP:0011813)1.79719373
83Recurrent viral infections (HP:0004429)1.79301909
84Apathy (HP:0000741)1.78634589
85Bowel diverticulosis (HP:0005222)1.78592013
86Metaphyseal dysplasia (HP:0100255)1.77551314
87Cellulitis (HP:0100658)1.77536949
88Abnormality of the frontal sinuses (HP:0002687)1.77341122
89Diminished motivation (HP:0000745)1.77285783
90Camptodactyly of toe (HP:0001836)1.76764857
91Vasculitis (HP:0002633)1.76402481
92Coronal craniosynostosis (HP:0004440)1.76266553
93Mitral regurgitation (HP:0001653)1.75795355
94Overgrowth (HP:0001548)1.75047986
95Hypoplasia of the iris (HP:0007676)1.74992966
96Ankle contracture (HP:0006466)1.74235748
97Insomnia (HP:0100785)1.73580247
98Slender build (HP:0001533)1.73531367
99Deviation of the hallux (HP:0010051)1.73456165
100Retrobulbar optic neuritis (HP:0100654)1.73362142
101Optic neuritis (HP:0100653)1.73362142
102Delayed cranial suture closure (HP:0000270)1.73296255
103Neonatal short-limb short stature (HP:0008921)1.72754655
104Recurrent skin infections (HP:0001581)1.72730118
105Glossoptosis (HP:0000162)1.72515951
106Congenital glaucoma (HP:0001087)1.71722685
107Increased connective tissue (HP:0009025)1.71384942
108Abnormality of the acetabulum (HP:0003170)1.70747782
109Elbow flexion contracture (HP:0002987)1.68271793
110Hyperextensible skin (HP:0000974)1.68243441
111Abnormality of the peritoneum (HP:0002585)1.68193366
112Ectopia lentis (HP:0001083)1.68056046
113Broad metatarsal (HP:0001783)1.67939524
114Hallux valgus (HP:0001822)1.66176280
115Uterine leiomyosarcoma (HP:0002891)1.66161219
116Leiomyosarcoma (HP:0100243)1.66161219
117Venous abnormality (HP:0002624)1.66049068
118Short nail (HP:0001799)1.65917329
119Generalized amyotrophy (HP:0003700)1.65785085
120Thick nail (HP:0001805)1.65059295
121Thoracolumbar scoliosis (HP:0002944)1.64898336
122Emphysema (HP:0002097)1.64075490
123Orchitis (HP:0100796)1.63478620
124Abnormality of carpal bone ossification (HP:0006257)1.63139021
125Germ cell neoplasia (HP:0100728)1.62324735
126Arnold-Chiari malformation (HP:0002308)1.62143498
127Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.62126793
128Scapular winging (HP:0003691)1.61539921
129Intrahepatic cholestasis (HP:0001406)1.61116242
130Abnormality of the intrinsic pathway (HP:0010989)1.60769752
131Short 4th metacarpal (HP:0010044)1.60515530
132Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.60515530
133Missing ribs (HP:0000921)1.60402170
134Mesomelia (HP:0003027)1.60263728
135Right ventricular cardiomyopathy (HP:0011663)1.60178871
136Type 1 muscle fiber predominance (HP:0003803)1.59860023
137Abnormal ossification of hand bones (HP:0005921)1.59859527
138Blue sclerae (HP:0000592)1.59832504
139Elevated erythrocyte sedimentation rate (HP:0003565)1.59728615
140Tibial bowing (HP:0002982)1.59169249
141Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.59168273
142Renal duplication (HP:0000075)1.58896303
143Abnormality of the distal phalanx of the thumb (HP:0009617)1.58835267
144Achilles tendon contracture (HP:0001771)1.58582424
145Distal lower limb amyotrophy (HP:0008944)1.58308545
146Hypothermia (HP:0002045)1.58197415
147Craniofacial hyperostosis (HP:0004493)1.58126291
148Myocardial infarction (HP:0001658)1.57971466
149Thin bony cortex (HP:0002753)1.57950911
150Hammertoe (HP:0001765)1.56375155
151Pectus excavatum (HP:0000767)1.55841519
152Protruding ear (HP:0000411)1.55780316
153Increased mean platelet volume (HP:0011877)1.55510376
154Hyperparathyroidism (HP:0000843)1.54949632
155Persistence of primary teeth (HP:0006335)1.54561620
156Mildly elevated creatine phosphokinase (HP:0008180)1.52755140
157Cortical dysplasia (HP:0002539)1.52487949
158Abnormality of the Achilles tendon (HP:0005109)1.50983609
159Delayed closure of the anterior fontanelle (HP:0001476)1.50455809
160Upper limb amyotrophy (HP:0009129)1.50412488
161Distal upper limb amyotrophy (HP:0007149)1.50412488

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD34.19100888
2MAP3K143.42770802
3AKT33.01893601
4TBK12.78369627
5NEK92.57585052
6ICK2.54166955
7TTN2.49764190
8JAK32.38850489
9EEF2K2.25212381
10MAP3K132.13976813
11TAF12.06835113
12SMG12.03681606
13BLK1.93931009
14JAK11.89374723
15MOS1.80688209
16RIPK41.79400551
17TRIB31.78027143
18PRPF4B1.77556802
19DMPK1.65228697
20PIM21.61491440
21PAK41.60146857
22IKBKE1.59870622
23STK31.55442446
24PKN21.54418617
25EIF2AK11.53750221
26TYK21.52745268
27PDGFRA1.52207838
28MET1.51419643
29PLK21.51322504
30IRAK41.49214906
31IKBKB1.48371000
32PNCK1.47199964
33LATS11.46895221
34DDR21.46155140
35BMX1.45358588
36SIK11.41995163
37RPS6KA41.30749580
38FGFR31.29491615
39MAP3K101.26618801
40RIPK11.25016157
41EPHB21.23988861
42EPHA31.20126758
43SCYL21.19684810
44CAMKK21.18817748
45LRRK21.18716011
46CDK91.17446196
47CSK1.16642160
48NTRK11.15708643
49ERBB31.14892186
50KSR21.14381872
51PBK1.13523979
52NEK11.13337827
53MAP3K21.11335535
54IRAK31.11177723
55ERBB41.10841552
56RET1.09909732
57MYLK1.08637002
58CAMK1G1.05954163
59MTOR1.05292231
60NME20.99422632
61MARK30.96529298
62MAP3K50.95875200
63FGR0.95514826
64BRAF0.95255159
65HCK0.94648643
66TGFBR20.93545452
67FGFR40.91878071
68ALK0.90848680
69TAOK20.89083177
70SGK30.88299540
71CAMK1D0.87475693
72YES10.86432628
73STK380.86001060
74NUAK10.84585709
75PDGFRB0.83904598
76ARAF0.83545821
77PAK30.83522619
78HIPK20.83439841
79ERN10.82488308
80PTK2B0.81802164
81STK100.81723284
82PRKCH0.81673223
83LATS20.80681695
84KSR10.80672937
85TTK0.75578832
86CDK70.74960297
87MAP4K10.74137005
88ADRBK10.73318694
89CHUK0.73072165
90FES0.73002962
91ILK0.71954429
92KIT0.71167144
93TGFBR10.68984895
94EPHB10.66759777
95TESK10.66234618
96CDC42BPA0.65712572
97STK38L0.65322364
98PAK60.64960698
99LCK0.64871414
100WNK10.64816890
101MAPKAPK50.63926677
102PAK20.61694664
103FRK0.61656163
104NEK20.61487213
105FER0.61056753
106MAP3K90.60978988
107CAMKK10.60960221
108ROCK20.60404386
109NTRK30.60027405
110TRPM70.59447495
111STK240.58262158
112MAP3K80.58012366
113PASK0.57081921
114MST1R0.56686467
115STK110.56601763
116INSR0.55957595
117MELK0.55606976
118MAP3K60.55465870
119PTK20.55283952
120PIM10.55053233
121CDK60.54125299
122ABL10.53995975
123CDK120.53572676
124ABL20.52885958
125IRAK10.52475895
126SYK0.52358482
127CDK140.51694620
128EGFR0.50598839
129PRKD20.50405977
130LIMK10.50235441
131PTK60.49977093
132ROCK10.49527985
133PRKCE0.49423378
134MAP3K10.49129309
135SGK20.48792860
136EIF2AK20.48432098
137GRK50.47550139
138EPHA20.47349804
139MAP3K30.46500585
140TYRO30.42914303
141TSSK60.40226894
142IRAK20.39155379
143STK40.38161640
144DYRK30.35576278
145BRSK20.34994623
146MAP3K120.33975437
147CDK40.33184798
148RAF10.32306191
149RPS6KA20.31754373
150TNK20.31176220
151LMTK20.29438294

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052162.30040588
2Prion diseases_Homo sapiens_hsa050201.93491421
3Endometrial cancer_Homo sapiens_hsa052131.89703443
4Leishmaniasis_Homo sapiens_hsa051401.76280249
5Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68109230
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65238468
7Graft-versus-host disease_Homo sapiens_hsa053321.54055970
8Central carbon metabolism in cancer_Homo sapiens_hsa052301.52662070
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50302761
10Malaria_Homo sapiens_hsa051441.47944685
11Osteoclast differentiation_Homo sapiens_hsa043801.47461670
12Measles_Homo sapiens_hsa051621.46233775
13Non-small cell lung cancer_Homo sapiens_hsa052231.45838416
14Viral myocarditis_Homo sapiens_hsa054161.42557430
15TNF signaling pathway_Homo sapiens_hsa046681.42382211
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41665208
17Allograft rejection_Homo sapiens_hsa053301.39118858
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39029952
19Type I diabetes mellitus_Homo sapiens_hsa049401.38998364
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37017560
21Pertussis_Homo sapiens_hsa051331.34163156
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.33266206
23Tuberculosis_Homo sapiens_hsa051521.30840632
24Salmonella infection_Homo sapiens_hsa051321.30736749
25Toxoplasmosis_Homo sapiens_hsa051451.28612307
26Insulin signaling pathway_Homo sapiens_hsa049101.26199453
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25181329
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22077642
29Rheumatoid arthritis_Homo sapiens_hsa053231.22068653
30Influenza A_Homo sapiens_hsa051641.21542822
31Chronic myeloid leukemia_Homo sapiens_hsa052201.21370247
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20492956
33Shigellosis_Homo sapiens_hsa051311.19906870
34Phagosome_Homo sapiens_hsa041451.19204159
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18535323
36Chemokine signaling pathway_Homo sapiens_hsa040621.17864775
37mTOR signaling pathway_Homo sapiens_hsa041501.17094948
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16100606
39Dorso-ventral axis formation_Homo sapiens_hsa043201.13834285
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13387402
41Hepatitis B_Homo sapiens_hsa051611.12714881
42Pancreatic cancer_Homo sapiens_hsa052121.11713679
43Acute myeloid leukemia_Homo sapiens_hsa052211.11106379
44Antigen processing and presentation_Homo sapiens_hsa046121.09673501
45Focal adhesion_Homo sapiens_hsa045101.08804656
46Herpes simplex infection_Homo sapiens_hsa051681.08001214
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.07916226
48B cell receptor signaling pathway_Homo sapiens_hsa046621.07906836
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06208217
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06079332
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05704554
52Notch signaling pathway_Homo sapiens_hsa043301.05505897
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.05505269
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05021714
55Legionellosis_Homo sapiens_hsa051341.04147254
56ECM-receptor interaction_Homo sapiens_hsa045121.03879149
57Proteoglycans in cancer_Homo sapiens_hsa052051.02775400
58Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02207698
59AMPK signaling pathway_Homo sapiens_hsa041521.02046990
60Amoebiasis_Homo sapiens_hsa051461.01154257
61Glioma_Homo sapiens_hsa052140.99692975
62Hippo signaling pathway_Homo sapiens_hsa043900.97285160
63Platelet activation_Homo sapiens_hsa046110.97146703
64Prolactin signaling pathway_Homo sapiens_hsa049170.97146474
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96416967
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96019871
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95735113
68Apoptosis_Homo sapiens_hsa042100.94359862
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94334708
70Tight junction_Homo sapiens_hsa045300.92293918
71Olfactory transduction_Homo sapiens_hsa047400.92034684
72Small cell lung cancer_Homo sapiens_hsa052220.89821171
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89689808
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.89577591
75Long-term potentiation_Homo sapiens_hsa047200.89175112
76Adherens junction_Homo sapiens_hsa045200.88727371
77Cell cycle_Homo sapiens_hsa041100.88492513
78Hepatitis C_Homo sapiens_hsa051600.88487780
79MicroRNAs in cancer_Homo sapiens_hsa052060.88282201
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86231627
81Pathways in cancer_Homo sapiens_hsa052000.85747948
82Renin-angiotensin system_Homo sapiens_hsa046140.85471471
83mRNA surveillance pathway_Homo sapiens_hsa030150.84951685
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84919483
85Prostate cancer_Homo sapiens_hsa052150.84857499
86Lysine degradation_Homo sapiens_hsa003100.84808714
87Autoimmune thyroid disease_Homo sapiens_hsa053200.84084145
88Renal cell carcinoma_Homo sapiens_hsa052110.82862301
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.82718227
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82703895
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81728175
92Choline metabolism in cancer_Homo sapiens_hsa052310.81227016
93Dilated cardiomyopathy_Homo sapiens_hsa054140.79947814
94Biosynthesis of amino acids_Homo sapiens_hsa012300.78962332
95Asthma_Homo sapiens_hsa053100.78376182
96FoxO signaling pathway_Homo sapiens_hsa040680.77965368
97Phenylalanine metabolism_Homo sapiens_hsa003600.77926429
98Melanoma_Homo sapiens_hsa052180.77281500
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77171261
100Colorectal cancer_Homo sapiens_hsa052100.77042784
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.77019776
102Vibrio cholerae infection_Homo sapiens_hsa051100.75643753
103Vitamin B6 metabolism_Homo sapiens_hsa007500.73905224
104Viral carcinogenesis_Homo sapiens_hsa052030.73890079
105T cell receptor signaling pathway_Homo sapiens_hsa046600.73502653
106Wnt signaling pathway_Homo sapiens_hsa043100.72983182
107Gap junction_Homo sapiens_hsa045400.72619576
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72527359
109Estrogen signaling pathway_Homo sapiens_hsa049150.72338214
110p53 signaling pathway_Homo sapiens_hsa041150.71851606
111African trypanosomiasis_Homo sapiens_hsa051430.71838670
112Cholinergic synapse_Homo sapiens_hsa047250.71665548
113MAPK signaling pathway_Homo sapiens_hsa040100.70988386
114Hematopoietic cell lineage_Homo sapiens_hsa046400.70856653
115Insulin resistance_Homo sapiens_hsa049310.69609652
116TGF-beta signaling pathway_Homo sapiens_hsa043500.69296781
117Endocytosis_Homo sapiens_hsa041440.68666274
118Arginine and proline metabolism_Homo sapiens_hsa003300.67958994
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67882693
120VEGF signaling pathway_Homo sapiens_hsa043700.67484332
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66994977
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65699320
123HTLV-I infection_Homo sapiens_hsa051660.65620794
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65329620
125GnRH signaling pathway_Homo sapiens_hsa049120.64536341
126Axon guidance_Homo sapiens_hsa043600.64421239
127Type II diabetes mellitus_Homo sapiens_hsa049300.64402652
128Fatty acid biosynthesis_Homo sapiens_hsa000610.63841944
129Vitamin digestion and absorption_Homo sapiens_hsa049770.63650869
130Cocaine addiction_Homo sapiens_hsa050300.63006412
131Ras signaling pathway_Homo sapiens_hsa040140.62323497
132Pyruvate metabolism_Homo sapiens_hsa006200.62214166
133Lysosome_Homo sapiens_hsa041420.62166333
134ErbB signaling pathway_Homo sapiens_hsa040120.62037231
135Pentose phosphate pathway_Homo sapiens_hsa000300.61864961
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61653003
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61304465
138Rap1 signaling pathway_Homo sapiens_hsa040150.61263451
139Dopaminergic synapse_Homo sapiens_hsa047280.61073755
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.61052760
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60868700
142Bladder cancer_Homo sapiens_hsa052190.60863542
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60858337
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60205262
145Epstein-Barr virus infection_Homo sapiens_hsa051690.58641593
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58606160
147HIF-1 signaling pathway_Homo sapiens_hsa040660.56667737
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56097000
149Other glycan degradation_Homo sapiens_hsa005110.54123224
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52758375
151Melanogenesis_Homo sapiens_hsa049160.52271102
152Carbon metabolism_Homo sapiens_hsa012000.50224307
153Adipocytokine signaling pathway_Homo sapiens_hsa049200.48105057
154Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48086938
155Protein digestion and absorption_Homo sapiens_hsa049740.47774454
156Hedgehog signaling pathway_Homo sapiens_hsa043400.46574359

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