AIF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.19726709
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.71347385
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.71347385
4modulation by symbiont of host immune response (GO:0052553)5.71347385
5positive regulation by symbiont of host defense response (GO:0052509)5.71347385
6modulation by symbiont of host defense response (GO:0052031)5.71347385
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.71347385
8neutrophil activation involved in immune response (GO:0002283)5.57998107
9macrophage activation involved in immune response (GO:0002281)5.47175585
10regulation of interferon-beta biosynthetic process (GO:0045357)5.46406061
11positive regulation of gamma-delta T cell activation (GO:0046645)5.16134637
12* microglial cell activation (GO:0001774)5.14341393
13positive regulation of interferon-alpha production (GO:0032727)5.06382814
14negative regulation of interleukin-12 production (GO:0032695)4.85915552
15G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.82658016
16regulation of interferon-alpha production (GO:0032647)4.79925766
17positive regulation of antigen processing and presentation (GO:0002579)4.67244863
18immunoglobulin mediated immune response (GO:0016064)4.50548037
19sperm motility (GO:0030317)4.48127488
20cell wall macromolecule catabolic process (GO:0016998)4.40819182
21cell wall macromolecule metabolic process (GO:0044036)4.40819182
22eosinophil chemotaxis (GO:0048245)4.39601908
23response to peptidoglycan (GO:0032494)4.35320245
24regulation of B cell receptor signaling pathway (GO:0050855)4.30979905
25positive regulation of mast cell activation (GO:0033005)4.28264947
26detection of other organism (GO:0098543)4.26772991
27regulation of dendritic cell antigen processing and presentation (GO:0002604)4.14490030
28fusion of sperm to egg plasma membrane (GO:0007342)4.13973765
29respiratory burst (GO:0045730)4.12525320
30detection of bacterium (GO:0016045)4.08946723
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.07904346
32negative regulation of cell killing (GO:0031342)4.07904346
33* macrophage activation (GO:0042116)3.98642176
34regulation of antigen processing and presentation (GO:0002577)3.97792494
35pinocytosis (GO:0006907)3.97343421
36multicellular organism reproduction (GO:0032504)3.94245464
37detection of molecule of bacterial origin (GO:0032490)3.90388095
38detection of external biotic stimulus (GO:0098581)3.87544739
39myeloid cell activation involved in immune response (GO:0002275)3.86859152
40eosinophil migration (GO:0072677)3.86555842
41positive regulation of cellular amide metabolic process (GO:0034250)3.76271970
42reproduction (GO:0000003)3.75900557
43regulation of myeloid leukocyte mediated immunity (GO:0002886)3.75897763
44neutrophil activation (GO:0042119)3.75145468
45regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.74415942
46acrosome reaction (GO:0007340)3.73381648
47regulation of mononuclear cell migration (GO:0071675)3.73197680
48regulation of mast cell activation (GO:0033003)3.72861279
49positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.71997113
50granulocyte activation (GO:0036230)3.69647456
51purinergic nucleotide receptor signaling pathway (GO:0035590)3.67053123
52regulation of macrophage chemotaxis (GO:0010758)3.66718042
53glycosphingolipid catabolic process (GO:0046479)3.64360325
54cellular response to exogenous dsRNA (GO:0071360)3.59990722
55response to host immune response (GO:0052572)3.59949283
56response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.59949283
57regulation of leukocyte degranulation (GO:0043300)3.56726037
58cellular extravasation (GO:0045123)3.56516711
59negative regulation of granulocyte differentiation (GO:0030853)3.55779324
60production of molecular mediator involved in inflammatory response (GO:0002532)3.53929815
61regulation of gamma-delta T cell activation (GO:0046643)3.53097588
62acrosome assembly (GO:0001675)3.50736840
63positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.49202142
64detection of biotic stimulus (GO:0009595)3.49152131
65monocyte chemotaxis (GO:0002548)3.48831654
66positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.48739348
67negative regulation of erythrocyte differentiation (GO:0045647)3.47152772
68lipopolysaccharide-mediated signaling pathway (GO:0031663)3.45080055
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.44529042
70sperm-egg recognition (GO:0035036)3.42709964
71response to muramyl dipeptide (GO:0032495)3.42030777
72antigen processing and presentation of endogenous antigen (GO:0019883)3.37178660
73sequestering of actin monomers (GO:0042989)3.34996138
74defense response to protozoan (GO:0042832)3.32526574
75positive regulation of leukocyte degranulation (GO:0043302)3.32056015
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.29081162
77regulation of hypersensitivity (GO:0002883)3.28820983
78positive regulation of interferon-beta production (GO:0032728)3.27420690
79G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.26153495
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.25374458
81response to host (GO:0075136)3.25374458
82response to host defenses (GO:0052200)3.25374458
83glycolipid catabolic process (GO:0019377)3.23967924
84cell-cell recognition (GO:0009988)3.23746241
85myeloid dendritic cell differentiation (GO:0043011)3.21180574
86interferon-gamma-mediated signaling pathway (GO:0060333)3.20340891
87response to protozoan (GO:0001562)3.18132708
88* myeloid leukocyte activation (GO:0002274)3.17791816
89lymphocyte chemotaxis (GO:0048247)3.17205467
90B cell mediated immunity (GO:0019724)3.17016013
91leukocyte mediated cytotoxicity (GO:0001909)3.16705300
92positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.13479257
93mature B cell differentiation involved in immune response (GO:0002313)3.12409984
94negative regulation of cytokine production involved in immune response (GO:0002719)3.12021416
95sexual reproduction (GO:0019953)3.11693383
96leukocyte aggregation (GO:0070486)3.10251984
97positive regulation of interleukin-12 production (GO:0032735)3.09343282
98antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.09075693
99positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.08726909
100regulation of mast cell degranulation (GO:0043304)3.08632944
101T-helper 1 type immune response (GO:0042088)3.08309808
102positive regulation of B cell differentiation (GO:0045579)3.07416272
103myeloid dendritic cell activation (GO:0001773)3.07319825
104lipoxygenase pathway (GO:0019372)3.07187952
105* positive regulation of monocyte chemotaxis (GO:0090026)3.06832040
106I-kappaB phosphorylation (GO:0007252)3.04041205
107natural killer cell mediated cytotoxicity (GO:0042267)3.00917116
108natural killer cell mediated immunity (GO:0002228)3.00917116
109cellular response to thyroid hormone stimulus (GO:0097067)3.00835278
110plasma membrane fusion (GO:0045026)2.99738561
111regulation of lymphocyte chemotaxis (GO:1901623)2.97379230
112cytokine secretion (GO:0050663)2.95279654
113positive regulation of mast cell degranulation (GO:0043306)2.94000259
114positive regulation of mast cell activation involved in immune response (GO:0033008)2.94000259
115regulation of mast cell activation involved in immune response (GO:0033006)2.93858506
116positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.93421407
117positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93206101
118Arp2/3 complex-mediated actin nucleation (GO:0034314)2.92278135
119ceramide catabolic process (GO:0046514)2.92265143
120positive regulation of macrophage cytokine production (GO:0060907)2.92078516
121purinergic receptor signaling pathway (GO:0035587)2.91874103
122regulation of tolerance induction (GO:0002643)2.91785438
123regulation of gamma-delta T cell differentiation (GO:0045586)2.90871088
124positive thymic T cell selection (GO:0045059)2.90762120
125oligosaccharide catabolic process (GO:0009313)2.90686361
126neutrophil mediated immunity (GO:0002446)2.90255340
127positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.89863103
128regulation of regulated secretory pathway (GO:1903305)2.89041084
129* cellular response to interferon-gamma (GO:0071346)2.88406154
130positive regulation of type 2 immune response (GO:0002830)2.87846036
131binding of sperm to zona pellucida (GO:0007339)2.86312243
132leukocyte degranulation (GO:0043299)2.86269606
133dendritic cell differentiation (GO:0097028)2.86238565
134regulation of T cell tolerance induction (GO:0002664)2.85322741
135regulation of B cell differentiation (GO:0045577)2.85219482
136regulation of interferon-gamma biosynthetic process (GO:0045072)2.84704988
137mast cell activation (GO:0045576)2.84234952
138lymphocyte mediated immunity (GO:0002449)2.82671378
139response to type I interferon (GO:0034340)2.82294626
140negative regulation of myeloid cell apoptotic process (GO:0033033)2.82291710
141adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.82040342
142type I interferon signaling pathway (GO:0060337)2.81454667
143cellular response to type I interferon (GO:0071357)2.81454667
144histamine secretion (GO:0001821)2.77380578
145antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.76877058
146germinal center formation (GO:0002467)2.75890992
147negative regulation of T cell mediated immunity (GO:0002710)2.72809814
148amino sugar catabolic process (GO:0046348)2.72085959
149positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.71685526
150negative regulation of leukocyte mediated immunity (GO:0002704)2.71338611

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse6.70526782
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.32237833
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.73913132
4* IRF8_27001747_Chip-Seq_BMDM_Mouse5.09776625
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.88370253
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.48562995
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.31468810
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.27817903
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.12038011
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.10890391
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.77023367
12VDR_21846776_ChIP-Seq_THP-1_Human2.73916540
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65687272
14* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63477985
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43396261
16PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.27661393
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18746615
18PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.10112854
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03578925
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00852005
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00556529
22VDR_24787735_ChIP-Seq_THP-1_Human1.99926739
23* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96371445
24* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89011460
25SCL_19346495_ChIP-Seq_HPC-7_Human1.88018759
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87180354
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83746242
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78083526
29UTX_26944678_Chip-Seq_JUKART_Human1.76535410
30* SPI1_23547873_ChIP-Seq_NB4_Human1.74661239
31PU_27001747_Chip-Seq_BMDM_Mouse1.73649348
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69936981
33* SPI1_23127762_ChIP-Seq_K562_Human1.69666633
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68859341
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68602736
36CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67820809
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65767619
38RUNX_20019798_ChIP-Seq_JUKART_Human1.62705168
39MYC_22102868_ChIP-Seq_BL_Human1.61018066
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.60667874
41PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57099858
42CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.53449076
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.43906996
44GATA1_19941827_ChIP-Seq_MEL_Mouse1.43325116
45* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42566315
46MYB_26560356_Chip-Seq_TH2_Human1.41833471
47CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40488433
48SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40232466
49MAF_26560356_Chip-Seq_TH2_Human1.37963636
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36881443
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32741765
52VDR_24763502_ChIP-Seq_THP-1_Human1.32089380
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29592111
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27933157
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27243737
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26328440
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25495873
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25032971
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23398404
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22841216
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22065192
62BCL6_27268052_Chip-Seq_Bcells_Human1.21067610
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18733519
64GATA1_22025678_ChIP-Seq_K562_Human1.18597518
65EGR1_19032775_ChIP-ChIP_M12_Human1.16786559
66GATA3_26560356_Chip-Seq_TH2_Human1.15640820
67STAT1_20625510_ChIP-Seq_HELA_Human1.13214821
68GATA1_19941826_ChIP-Seq_K562_Human1.12904981
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12608683
70LXR_22292898_ChIP-Seq_THP-1_Human1.08332125
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06965088
72MAF_26560356_Chip-Seq_TH1_Human1.06188553
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.06151362
74KDM2B_26808549_Chip-Seq_DND41_Human1.05409988
75BCOR_27268052_Chip-Seq_Bcells_Human1.04115120
76VDR_22108803_ChIP-Seq_LS180_Human1.01194783
77MYB_26560356_Chip-Seq_TH1_Human1.00933811
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.00600392
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00299374
80GATA3_27048872_Chip-Seq_THYMUS_Human0.97770262
81TFEB_21752829_ChIP-Seq_HELA_Human0.97491447
82SPI1_20517297_ChIP-Seq_HL60_Human0.97202762
83FLI1_27457419_Chip-Seq_LIVER_Mouse0.95124969
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93306614
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93275333
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92618931
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91662184
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89838673
89EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89686267
90SMRT_27268052_Chip-Seq_Bcells_Human0.89429167
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88321096
92* IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87748705
93* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85457269
94STAT1_17558387_ChIP-Seq_HELA_Human0.83777696
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82860468
96CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82349121
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82211744
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80801457
99KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.80467835
100NCOR1_26117541_ChIP-Seq_K562_Human0.79689430
101PU1_27457419_Chip-Seq_LIVER_Mouse0.79680855
102CTCF_26484167_Chip-Seq_Bcells_Mouse0.79452506
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79419998
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.79138447
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78561710
106GATA3_21867929_ChIP-Seq_TH1_Mouse0.77951094
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76394118
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76205932
109LXR_22158963_ChIP-Seq_LIVER_Mouse0.75525437
110TCF7_22412390_ChIP-Seq_EML_Mouse0.75278072
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71679631
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71461271
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.71430692
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71258240
115ELK4_26923725_Chip-Seq_MESODERM_Mouse0.70688794
116EGR1_19374776_ChIP-ChIP_THP-1_Human0.70658179
117PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70609178
118FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70277963
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69756609
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.69158888
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.69114887
122CMYC_18555785_Chip-Seq_ESCs_Mouse0.67720355
123SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.67439889
124PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67030349
125SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66871220
126GATA1_19941827_ChIP-Seq_MEL86_Mouse0.66575922
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.65813828
128GATA3_21867929_ChIP-Seq_CD8_Mouse0.64818680
129GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63503694
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.63141070
131ESRRB_18555785_Chip-Seq_ESCs_Mouse0.63107453
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.62780163
133RUNX1_27457419_Chip-Seq_LIVER_Mouse0.62381265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.91093824
2MP0005410_abnormal_fertilization4.09832198
3MP0006082_CNS_inflammation3.93373902
4MP0002148_abnormal_hypersensitivity_rea3.87278791
5MP0005058_abnormal_lysosome_morphology3.48163695
6MP0003436_decreased_susceptibility_to3.46866447
7MP0005671_abnormal_response_to3.18461490
8MP0002419_abnormal_innate_immunity3.14707452
9MP0005000_abnormal_immune_tolerance2.96407700
10MP0009785_altered_susceptibility_to2.90551268
11MP0003191_abnormal_cellular_cholesterol2.89746414
12MP0005025_abnormal_response_to2.67685575
13MP0002452_abnormal_antigen_presenting2.63299601
14MP0001790_abnormal_immune_system2.61247986
15MP0005387_immune_system_phenotype2.61247986
16MP0003303_peritoneal_inflammation2.59807245
17MP0000685_abnormal_immune_system2.52031970
18MP0001800_abnormal_humoral_immune2.51374752
19MP0005464_abnormal_platelet_physiology2.45143907
20MP0002723_abnormal_immune_serum2.42847329
21MP0004510_myositis2.40378128
22MP0003172_abnormal_lysosome_physiology2.33331607
23MP0009840_abnormal_foam_cell2.30485719
24MP0003806_abnormal_nucleotide_metabolis2.26979104
25MP0001819_abnormal_immune_cell2.13707890
26MP0002420_abnormal_adaptive_immunity2.08847864
27MP0003724_increased_susceptibility_to1.99182623
28MP0003690_abnormal_glial_cell1.98061376
29MP0002405_respiratory_system_inflammati1.96834084
30MP0003075_altered_response_to1.92444758
31MP0001853_heart_inflammation1.92227186
32MP0001533_abnormal_skeleton_physiology1.88800340
33MP0005310_abnormal_salivary_gland1.84122687
34MP0000343_altered_response_to1.71055781
35MP0002254_reproductive_system_inflammat1.69707055
36MP0001845_abnormal_inflammatory_respons1.69472972
37MP0008469_abnormal_protein_level1.65680198
38MP0009764_decreased_sensitivity_to1.54606751
39MP0009333_abnormal_splenocyte_physiolog1.53565387
40MP0000604_amyloidosis1.48646284
41MP0000716_abnormal_immune_system1.45882746
42MP0002277_abnormal_respiratory_mucosa1.41460939
43MP0002998_abnormal_bone_remodeling1.33475587
44MP0002166_altered_tumor_susceptibility1.31129456
45MP0002138_abnormal_hepatobiliary_system1.28612012
46MP0005166_decreased_susceptibility_to1.27055150
47MP0002398_abnormal_bone_marrow1.26444531
48MP0003448_altered_tumor_morphology1.25357429
49MP0008260_abnormal_autophagy1.24192048
50MP0005451_abnormal_body_composition1.19689735
51MP0004947_skin_inflammation1.19359900
52MP0000689_abnormal_spleen_morphology1.18539761
53MP0010155_abnormal_intestine_physiology1.17919431
54MP0002139_abnormal_hepatobiliary_system1.15438698
55MP0002429_abnormal_blood_cell1.13135342
56MP0003183_abnormal_peptide_metabolism1.12346771
57MP0003866_abnormal_defecation1.09412657
58MP0002006_tumorigenesis1.08844851
59MP0000569_abnormal_digit_pigmentation1.08783461
60MP0005670_abnormal_white_adipose1.04757244
61MP0004883_abnormal_blood_vessel1.03433514
62MP0000249_abnormal_blood_vessel1.01357393
63MP0005167_abnormal_blood-brain_barrier1.00347871
64MP0002722_abnormal_immune_system0.98436581
65MP0002132_abnormal_respiratory_system0.97359034
66MP0000858_altered_metastatic_potential0.94247529
67MP0001663_abnormal_digestive_system0.93730461
68MP0003656_abnormal_erythrocyte_physiolo0.91643214
69MP0003300_gastrointestinal_ulcer0.91218367
70MP0003698_abnormal_male_reproductive0.89215087
71MP0003045_fibrosis0.88755490
72MP0005164_abnormal_response_to0.88629708
73MP0000920_abnormal_myelination0.88442479
74MP0006054_spinal_hemorrhage0.86919580
75MP0002090_abnormal_vision0.85549477
76MP0004808_abnormal_hematopoietic_stem0.85471826
77MP0000703_abnormal_thymus_morphology0.83705468
78MP0001929_abnormal_gametogenesis0.83279302
79MP0009763_increased_sensitivity_to0.82284336
80MP0003828_pulmonary_edema0.80520782
81MP0001545_abnormal_hematopoietic_system0.78922723
82MP0005397_hematopoietic_system_phenotyp0.78922723
83MP0001851_eye_inflammation0.77953700
84MP0009765_abnormal_xenobiotic_induced0.77806248
85MP0002928_abnormal_bile_duct0.76096599
86MP0005390_skeleton_phenotype0.75307373
87MP0010307_abnormal_tumor_latency0.74977884
88MP0005075_abnormal_melanosome_morpholog0.74952128
89MP0003279_aneurysm0.74665956
90MP0009278_abnormal_bone_marrow0.73763272
91MP0000767_abnormal_smooth_muscle0.71955478
92MP0003252_abnormal_bile_duct0.70799552
93MP0005174_abnormal_tail_pigmentation0.69096732
94MP0002295_abnormal_pulmonary_circulatio0.68930706
95MP0008438_abnormal_cutaneous_collagen0.68417013
96MP0004782_abnormal_surfactant_physiolog0.67136548
97MP0000609_abnormal_liver_physiology0.66112793
98MP0005319_abnormal_enzyme/_coenzyme0.65712270
99MP0000371_diluted_coat_color0.65580707
100MP0002933_joint_inflammation0.64585783
101MP0001873_stomach_inflammation0.64084523
102MP0000490_abnormal_crypts_of0.63789139
103MP0002136_abnormal_kidney_physiology0.63716879
104MP0000465_gastrointestinal_hemorrhage0.61142606
105MP0008874_decreased_physiological_sensi0.60646585
106MP0008004_abnormal_stomach_pH0.59077050
107MP0001542_abnormal_bone_strength0.57554563
108MP0000015_abnormal_ear_pigmentation0.56901323
109MP0001915_intracranial_hemorrhage0.56672161
110MP0003795_abnormal_bone_structure0.55842439
111MP0005535_abnormal_body_temperature0.55670135
112MP0004019_abnormal_vitamin_homeostasis0.53588506
113MP0005165_increased_susceptibility_to0.52622501
114MP0005365_abnormal_bile_salt0.51934508
115MP0003453_abnormal_keratinocyte_physiol0.51280600
116MP0002332_abnormal_exercise_endurance0.51250268
117MP0005584_abnormal_enzyme/coenzyme_acti0.51076964
118MP0005381_digestive/alimentary_phenotyp0.49420264
119MP0002396_abnormal_hematopoietic_system0.49305426
120MP0003633_abnormal_nervous_system0.49172817
121MP0002019_abnormal_tumor_incidence0.48986421
122MP0008873_increased_physiological_sensi0.48968998
123MP0002693_abnormal_pancreas_physiology0.46813021
124MP0003763_abnormal_thymus_physiology0.46422646

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.94356244
2Glomerulonephritis (HP:0000099)6.37257631
3Recurrent abscess formation (HP:0002722)6.31107611
4Recurrent bacterial skin infections (HP:0005406)5.97546624
5Eczematoid dermatitis (HP:0000976)5.31639102
6Complement deficiency (HP:0004431)5.18241290
7Abnormality of complement system (HP:0005339)5.13124761
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.79180379
9Recurrent gram-negative bacterial infections (HP:0005420)4.76465843
10Increased cerebral lipofuscin (HP:0011813)4.73031546
11Abnormality of liposaccharide metabolism (HP:0010968)4.42457156
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.42457156
13Abnormality of glycolipid metabolism (HP:0010969)4.42457156
14Nephritis (HP:0000123)4.15253691
15Dynein arm defect of respiratory motile cilia (HP:0012255)4.09269999
16Absent/shortened dynein arms (HP:0200106)4.09269999
17Vacuolated lymphocytes (HP:0001922)4.05281772
18Abnormality of macrophages (HP:0004311)3.79933987
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.73002299
20Axonal loss (HP:0003447)3.70190007
21Disinhibition (HP:0000734)3.68062939
22Recurrent skin infections (HP:0001581)3.58680097
23Chronic obstructive pulmonary disease (HP:0006510)3.57477565
24Obstructive lung disease (HP:0006536)3.57477565
25Myositis (HP:0100614)3.56498164
26Mediastinal lymphadenopathy (HP:0100721)3.35014217
27Petechiae (HP:0000967)3.31728727
28Dysostosis multiplex (HP:0000943)3.29485442
29Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.26774269
30Orchitis (HP:0100796)3.26386161
31Thick nail (HP:0001805)3.24723007
32Nasal polyposis (HP:0100582)3.23715658
33Retrobulbar optic neuritis (HP:0100654)3.18489163
34Optic neuritis (HP:0100653)3.18489163
35Agnosia (HP:0010524)3.17751805
36Purpura (HP:0000979)3.05045583
37Elevated erythrocyte sedimentation rate (HP:0003565)3.04994864
38Gingivitis (HP:0000230)2.97424799
39Basal ganglia calcification (HP:0002135)2.94614310
40Loss of speech (HP:0002371)2.88704720
41Mutism (HP:0002300)2.88300426
42Upper motor neuron abnormality (HP:0002127)2.87113361
43Prolonged bleeding time (HP:0003010)2.86917246
44Encephalitis (HP:0002383)2.83910893
45Epistaxis (HP:0000421)2.83231506
46Recurrent fungal infections (HP:0002841)2.82960501
47Colitis (HP:0002583)2.81411935
48Myocardial infarction (HP:0001658)2.78616972
49Abnormality of the nasal mucosa (HP:0000433)2.77667374
50Pustule (HP:0200039)2.76808002
51Increased serum ferritin (HP:0003281)2.73004519
52Chest pain (HP:0100749)2.66915172
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.66174019
54Vasculitis (HP:0002633)2.65586516
55Spontaneous hematomas (HP:0007420)2.63067123
56Recurrent viral infections (HP:0004429)2.62039258
57Hematochezia (HP:0002573)2.59001532
58Autoimmune thrombocytopenia (HP:0001973)2.58982280
59Increased IgE level (HP:0003212)2.55954014
60Gingival bleeding (HP:0000225)2.53941987
61Gastrointestinal infarctions (HP:0005244)2.53674286
62Abnormality of the vasculature of the conjunctiva (HP:0008054)2.47997864
63Abnormality of the prostate (HP:0008775)2.47678032
64Progressive visual loss (HP:0000529)2.47149708
65Abnormal respiratory motile cilium physiology (HP:0012261)2.45792595
66Abnormal respiratory epithelium morphology (HP:0012253)2.43316989
67Abnormal respiratory motile cilium morphology (HP:0005938)2.43316989
68Osteolytic defects of the hand bones (HP:0009699)2.43163196
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.43163196
70Retinal atrophy (HP:0001105)2.43068908
71Thrombocytosis (HP:0001894)2.42620413
72Abnormality of iron homeostasis (HP:0011031)2.42335076
73Pulmonary infiltrates (HP:0002113)2.42195226
74Meningitis (HP:0001287)2.38900927
75Stomatitis (HP:0010280)2.38564142
76Panhypogammaglobulinemia (HP:0003139)2.37601295
77Arterial thrombosis (HP:0004420)2.35730146
78Hepatosplenomegaly (HP:0001433)2.35683771
79Pulmonary embolism (HP:0002204)2.35407814
80Recurrent cutaneous fungal infections (HP:0011370)2.34014215
81Chronic mucocutaneous candidiasis (HP:0002728)2.34014215
82T lymphocytopenia (HP:0005403)2.33808429
83Mucopolysacchariduria (HP:0008155)2.33569271
84Urinary glycosaminoglycan excretion (HP:0003541)2.33569271
85Chronic diarrhea (HP:0002028)2.31418275
86Prostate neoplasm (HP:0100787)2.31070964
87Periodontitis (HP:0000704)2.30842762
88Gangrene (HP:0100758)2.30670233
89Abnormality of the pleura (HP:0002103)2.29370533
90Inflammation of the large intestine (HP:0002037)2.28309444
91Pathologic fracture (HP:0002756)2.27143439
92Polyneuropathy (HP:0001271)2.27131470
93Recurrent sinusitis (HP:0011108)2.24696036
94Episodic fever (HP:0001954)2.23240233
95Abnormality of T cell number (HP:0011839)2.22908221
96Hypergammaglobulinemia (HP:0010702)2.22176768
97Granulocytopenia (HP:0001913)2.20628789
98Amyloidosis (HP:0011034)2.16746807
99Agammaglobulinemia (HP:0004432)2.15722671
100Abnormality of polysaccharide metabolism (HP:0011012)2.12501184
101Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12501184
102Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12501184
103Cellulitis (HP:0100658)2.10577730
104Recurrent pneumonia (HP:0006532)2.09859099
105J-shaped sella turcica (HP:0002680)2.09344633
106Neurofibrillary tangles (HP:0002185)2.09314565
107Vertigo (HP:0002321)2.06734166
108Autoimmune hemolytic anemia (HP:0001890)2.06551333
109Progressive neurologic deterioration (HP:0002344)2.06339428
110Osteomyelitis (HP:0002754)2.04896124
111Gastrointestinal inflammation (HP:0004386)2.00928313
112Rhinitis (HP:0012384)2.00890014
113Abnormality of transition element cation homeostasis (HP:0011030)2.00440798
114Glomerulopathy (HP:0100820)1.99179754
115Abnormality of T cells (HP:0002843)1.99059965
116Joint hemorrhage (HP:0005261)1.98966167
117Hemoptysis (HP:0002105)1.98747216
118Anorexia (HP:0002039)1.98207993
119Infertility (HP:0000789)1.97620214
120Arterial tortuosity (HP:0005116)1.97476772
121Chronic otitis media (HP:0000389)1.96149516
122Keratoconjunctivitis sicca (HP:0001097)1.95118246
123Abnormality of B cell number (HP:0010975)1.94390217
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92602507
125Amaurosis fugax (HP:0100576)1.92506580
126Interstitial pulmonary disease (HP:0006530)1.92502899
127Azoospermia (HP:0000027)1.90500169
128Sepsis (HP:0100806)1.90314203
129Urticaria (HP:0001025)1.89166381
130Peripheral demyelination (HP:0011096)1.87860533
131Bone pain (HP:0002653)1.87116637
132Abnormal ciliary motility (HP:0012262)1.85802157
133Increased IgM level (HP:0003496)1.85374169
134Recurrent lower respiratory tract infections (HP:0002783)1.83041748
135Leukocytosis (HP:0001974)1.81436198
136Recurrent bronchitis (HP:0002837)1.81106680
137Keratoconjunctivitis (HP:0001096)1.80120373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.04664486
2TGFBR24.10140917
3MAP3K143.81254409
4RIPK43.50603202
5TYK23.37956917
6IRAK43.27362424
7TBK13.12329989
8GRK72.80603771
9PDK22.68136057
10MAP4K12.64795143
11CSF1R2.42164871
12KIT2.30946846
13NME22.30466192
14IRAK32.29489622
15IKBKB2.18193630
16NEK92.16418216
17TESK12.09229609
18TXK2.04416685
19IKBKE1.96510873
20MAP3K111.95212803
21JAK11.85097709
22TNK21.79454883
23ZAP701.76989169
24TESK21.70637971
25CSK1.64877993
26PDK31.62117093
27PDK41.62117093
28BMPR21.57422670
29SYK1.52919427
30TAOK21.48037392
31PRPF4B1.46015842
32JAK31.44411498
33GRK61.43152581
34LYN1.37259345
35MAP3K131.36364634
36EPHB11.32704011
37TAOK11.28957995
38TAOK31.24924783
39MATK1.24065052
40HCK1.20939395
41CDK191.14594049
42BTK1.11581054
43CHUK1.11127802
44ERN11.08752740
45STK101.08481443
46PDK11.06737539
47LCK1.06721424
48JAK21.05768328
49MAP3K11.03910767
50MAPK151.02948612
51ITK1.02756537
52FES1.02561588
53ADRBK21.01978979
54BCKDK1.00659531
55TEC0.98517286
56CLK10.98223261
57MOS0.97269875
58CAMKK20.95529899
59PTK2B0.92180049
60PBK0.90623814
61IRAK10.85920440
62FGR0.85328506
63MAP3K100.82927815
64PIM20.79963989
65PAK40.77686307
66KDR0.75925032
67CAMK1D0.73935314
68PDPK10.71733271
69ACVR1B0.68705478
70PRKCD0.68437097
71IRAK20.65485518
72ICK0.65422120
73PIM10.62525608
74EIF2AK20.61369799
75FGFR40.60109902
76DYRK1B0.59772046
77MARK30.58654237
78PKN10.56104250
79ARAF0.55852461
80RPS6KC10.54364030
81RPS6KL10.54364030
82PIK3CG0.54166928
83EGFR0.53965132
84CAMK1G0.53088398
85DAPK20.52330269
86CDC42BPA0.51462121
87MAPK120.51308000
88PRKD30.48153767
89RPS6KA60.47746842
90PRKCQ0.47272248
91CDK60.46525670
92MAP2K30.45073093
93LRRK20.44904590
94FGFR30.43856732
95HIPK20.43575080
96YES10.43505398
97MST40.43415473
98SIK30.43373164
99MAPKAPK20.43053101
100CAMKK10.40336687
101SCYL20.39594796
102MAP3K60.38716793
103MAPK70.38468167
104SIK20.38363733
105ABL10.37580353
106ERBB30.36482134
107IGF1R0.36456268
108NUAK10.35908269
109STK30.34465996
110STK40.34091721
111ABL20.33115869
112RPS6KA40.32685822
113DAPK10.31106970
114GRK50.30406594
115DDR20.30382033
116MARK20.27796964
117MAP3K50.27322214
118CDK40.26731217
119MAP2K60.25551422
120FLT30.25499490
121WNK10.24170692
122FYN0.24020561
123TRPM70.21735713
124MAP3K90.21606459
125DAPK30.20757420
126MAP3K120.20643372
127INSR0.20547126
128BMPR1B0.20498235
129PTK60.19742543
130RIPK10.19088098
131MAP3K30.16581151
132MAPK40.16541490

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.23066475
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.23384979
3Lysosome_Homo sapiens_hsa041422.87800880
4Leishmaniasis_Homo sapiens_hsa051402.85781067
5Other glycan degradation_Homo sapiens_hsa005112.78290964
6Osteoclast differentiation_Homo sapiens_hsa043802.69787185
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.64726051
8Pertussis_Homo sapiens_hsa051332.41161591
9Antigen processing and presentation_Homo sapiens_hsa046122.27225870
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.23943998
11Legionellosis_Homo sapiens_hsa051342.16988336
12Allograft rejection_Homo sapiens_hsa053302.06834489
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.02818183
14Complement and coagulation cascades_Homo sapiens_hsa046102.01382790
15Tuberculosis_Homo sapiens_hsa051521.99990630
16B cell receptor signaling pathway_Homo sapiens_hsa046621.99921588
17Graft-versus-host disease_Homo sapiens_hsa053321.97210708
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.75567178
19Rheumatoid arthritis_Homo sapiens_hsa053231.75411647
20Measles_Homo sapiens_hsa051621.74205857
21Salmonella infection_Homo sapiens_hsa051321.72829528
22Phagosome_Homo sapiens_hsa041451.72819462
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72562375
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.66577426
25Malaria_Homo sapiens_hsa051441.66028954
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63437428
27Toxoplasmosis_Homo sapiens_hsa051451.61365539
28Chemokine signaling pathway_Homo sapiens_hsa040621.61233507
29Influenza A_Homo sapiens_hsa051641.56344615
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55085404
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49459029
32Asthma_Homo sapiens_hsa053101.45384639
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42780607
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40554029
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39475396
36Prion diseases_Homo sapiens_hsa050201.38717519
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15879824
38African trypanosomiasis_Homo sapiens_hsa051431.15583231
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12137719
40Herpes simplex infection_Homo sapiens_hsa051681.07952082
41Apoptosis_Homo sapiens_hsa042101.06874803
42TNF signaling pathway_Homo sapiens_hsa046681.05577345
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.03139118
44Autoimmune thyroid disease_Homo sapiens_hsa053201.00665558
45Shigellosis_Homo sapiens_hsa051310.98323651
46Hematopoietic cell lineage_Homo sapiens_hsa046400.97786028
47Type I diabetes mellitus_Homo sapiens_hsa049400.97645520
48Primary immunodeficiency_Homo sapiens_hsa053400.94398231
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89335426
50Mineral absorption_Homo sapiens_hsa049780.87895941
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87097542
52Viral myocarditis_Homo sapiens_hsa054160.84631870
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84089151
54Ether lipid metabolism_Homo sapiens_hsa005650.80462806
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80031855
56Arachidonic acid metabolism_Homo sapiens_hsa005900.79960799
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75821529
58Hepatitis B_Homo sapiens_hsa051610.72651587
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69227286
60Platelet activation_Homo sapiens_hsa046110.67867785
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.66462955
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66288167
63T cell receptor signaling pathway_Homo sapiens_hsa046600.65262932
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63885321
65Endocytosis_Homo sapiens_hsa041440.50768826
66ABC transporters_Homo sapiens_hsa020100.49484114
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48359138
68Amoebiasis_Homo sapiens_hsa051460.48191806
69Hepatitis C_Homo sapiens_hsa051600.46414482
70Systemic lupus erythematosus_Homo sapiens_hsa053220.40496111
71Pancreatic cancer_Homo sapiens_hsa052120.40354211
72PPAR signaling pathway_Homo sapiens_hsa033200.40246832
73HTLV-I infection_Homo sapiens_hsa051660.38792785
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36273049
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35971411
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35429960
77Dorso-ventral axis formation_Homo sapiens_hsa043200.34901470
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34711035
79Renin-angiotensin system_Homo sapiens_hsa046140.34364458
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34337034
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.31460492
82Collecting duct acid secretion_Homo sapiens_hsa049660.31026408
83Fatty acid biosynthesis_Homo sapiens_hsa000610.30130961
84Epstein-Barr virus infection_Homo sapiens_hsa051690.29837655
85Bladder cancer_Homo sapiens_hsa052190.29428279
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27647249
87Chronic myeloid leukemia_Homo sapiens_hsa052200.27423058
88Acute myeloid leukemia_Homo sapiens_hsa052210.26909950
89Regulation of autophagy_Homo sapiens_hsa041400.26602587
90Sphingolipid metabolism_Homo sapiens_hsa006000.26386601
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25494871
92Vitamin B6 metabolism_Homo sapiens_hsa007500.24658810
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22859764
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22570882
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22258937
96Prolactin signaling pathway_Homo sapiens_hsa049170.22075237
97Non-small cell lung cancer_Homo sapiens_hsa052230.22009096
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.21844985
99VEGF signaling pathway_Homo sapiens_hsa043700.20875743
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.20527005
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20149327
102HIF-1 signaling pathway_Homo sapiens_hsa040660.19811481
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19618704
104Viral carcinogenesis_Homo sapiens_hsa052030.19179662
105Renin secretion_Homo sapiens_hsa049240.18743013
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17631319
107Linoleic acid metabolism_Homo sapiens_hsa005910.17479909
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.16041499
109Galactose metabolism_Homo sapiens_hsa000520.14944000
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12228253
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.12207828
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.12104279
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.09028830
114Pentose phosphate pathway_Homo sapiens_hsa000300.08110007
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08049066
116Glutathione metabolism_Homo sapiens_hsa004800.06256598
117MAPK signaling pathway_Homo sapiens_hsa040100.04991577
118Notch signaling pathway_Homo sapiens_hsa043300.04764756

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