AIF1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular basement membrane development (GO:0032836)8.07778242
2glomerular visceral epithelial cell development (GO:0072015)8.01615701
3glomerular epithelial cell development (GO:0072310)7.19988259
4glomerulus development (GO:0032835)5.54206179
5metanephric epithelium development (GO:0072207)4.86810537
6L-serine metabolic process (GO:0006563)4.54841762
7metanephric mesenchyme development (GO:0072075)4.35467151
8mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.33510004
9kidney mesenchyme development (GO:0072074)4.30661764
10paraxial mesoderm development (GO:0048339)4.23508254
11metanephric tubule development (GO:0072170)4.23244417
12metanephric nephron tubule development (GO:0072234)4.23244417
13metanephric nephron epithelium development (GO:0072243)4.18763619
14muscle cell fate commitment (GO:0042693)4.06296190
15branching involved in salivary gland morphogenesis (GO:0060445)4.05660993
16negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.95773143
17nephron tubule formation (GO:0072079)3.87386773
18establishment of integrated proviral latency (GO:0075713)3.77048989
19collecting duct development (GO:0072044)3.71567037
20excretion (GO:0007588)3.66999545
21regulation of mesenchymal cell apoptotic process (GO:2001053)3.59247958
22regulation of hippo signaling (GO:0035330)3.58680562
23protein complex localization (GO:0031503)3.56445474
24actin-myosin filament sliding (GO:0033275)3.51444618
25muscle filament sliding (GO:0030049)3.51444618
26hippo signaling (GO:0035329)3.49649832
27thyroid hormone generation (GO:0006590)3.47927828
28nephron tubule development (GO:0072080)3.47801598
29regulation of gene silencing by RNA (GO:0060966)3.44116343
30regulation of posttranscriptional gene silencing (GO:0060147)3.44116343
31regulation of gene silencing by miRNA (GO:0060964)3.44116343
32axon ensheathment in central nervous system (GO:0032291)3.42374204
33central nervous system myelination (GO:0022010)3.42374204
34regulation of apoptotic process involved in morphogenesis (GO:1902337)3.40910078
35amino acid import (GO:0043090)3.34169010
36epithelial cell-cell adhesion (GO:0090136)3.33745548
37L-amino acid import (GO:0043092)3.32754935
38response to mercury ion (GO:0046689)3.29668432
39presynaptic membrane assembly (GO:0097105)3.29583273
40mesenchymal to epithelial transition (GO:0060231)3.28541879
41outer ear morphogenesis (GO:0042473)3.27718717
42actin-mediated cell contraction (GO:0070252)3.27248562
43renal filtration (GO:0097205)3.27019256
44DNA unwinding involved in DNA replication (GO:0006268)3.25930379
45nephron epithelium development (GO:0072009)3.24677630
46mesodermal cell differentiation (GO:0048333)3.24087583
47actin filament depolymerization (GO:0030042)3.23986292
48positive regulation of p38MAPK cascade (GO:1900745)3.23356443
49negative regulation of metanephros development (GO:0072217)3.22201628
50planar cell polarity pathway involved in neural tube closure (GO:0090179)3.18998137
51diaphragm development (GO:0060539)3.16586435
52pre-miRNA processing (GO:0031054)3.13678156
53respiratory tube development (GO:0030323)3.11518338
54renal absorption (GO:0070293)3.10202104
55chondrocyte proliferation (GO:0035988)3.08270060
56presynaptic membrane organization (GO:0097090)3.05418362
57hyperosmotic salinity response (GO:0042538)3.05310611
58mesonephros development (GO:0001823)3.04381088
59sodium ion export (GO:0071436)3.03906978
60negative regulation of axon guidance (GO:1902668)3.02635644
61renal tubule development (GO:0061326)3.00617398
62organ induction (GO:0001759)3.00448800
63cellular protein complex localization (GO:0034629)2.98967115
64serine family amino acid biosynthetic process (GO:0009070)2.98033962
65cell adhesion mediated by integrin (GO:0033627)2.96145746
66myelin maintenance (GO:0043217)2.94519196
67regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.90120545
68positive regulation of male gonad development (GO:2000020)2.89680390
69postsynaptic membrane organization (GO:0001941)2.88530677
70skeletal muscle organ development (GO:0060538)2.88456773
71histone arginine methylation (GO:0034969)2.87180270
72convergent extension (GO:0060026)2.87112147
73branching involved in ureteric bud morphogenesis (GO:0001658)2.86484127
74pattern specification involved in kidney development (GO:0061004)2.84828395
75regulation of organ formation (GO:0003156)2.84624223
76mesenchyme development (GO:0060485)2.84590127
77G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.84218247
78myoblast fusion (GO:0007520)2.83995854
79neurotransmitter uptake (GO:0001504)2.83727294
80negative regulation of axon extension involved in axon guidance (GO:0048843)2.81742464
81lung-associated mesenchyme development (GO:0060484)2.81350130
82muscle cell migration (GO:0014812)2.79285033
83kidney epithelium development (GO:0072073)2.76820553
84neuron projection extension involved in neuron projection guidance (GO:1902284)2.76811199
85axon extension involved in axon guidance (GO:0048846)2.76811199
86regulation of heart morphogenesis (GO:2000826)2.74570844
87lateral sprouting from an epithelium (GO:0060601)2.74027697
88regulation of glomerulus development (GO:0090192)2.72439525
89apical protein localization (GO:0045176)2.72089159
90regulation of mesonephros development (GO:0061217)2.71142462
91mesonephric epithelium development (GO:0072163)2.70944579
92negative regulation of complement activation (GO:0045916)2.70320284
93mesonephric tubule development (GO:0072164)2.69895805
94plasma membrane repair (GO:0001778)2.69178416
95actin filament-based movement (GO:0030048)2.68653795
96heterochromatin organization (GO:0070828)2.68292296
97phosphate ion transport (GO:0006817)2.66764117
98regulation of cell fate specification (GO:0042659)2.66700364
99peptidyl-arginine omega-N-methylation (GO:0035247)2.66015404
100negative regulation of kidney development (GO:0090185)2.65934462
101DNA strand elongation involved in DNA replication (GO:0006271)2.65768519
102cell migration involved in sprouting angiogenesis (GO:0002042)2.65584003
103positive regulation of mesonephros development (GO:0061213)2.65378963
104thyroid hormone metabolic process (GO:0042403)2.64263079
105cellular potassium ion homeostasis (GO:0030007)2.60362075
106ureteric bud development (GO:0001657)2.60319906
107cellular response to vitamin D (GO:0071305)2.59147693
108mesenchymal cell proliferation (GO:0010463)2.58981528
109aminoglycoside antibiotic metabolic process (GO:0030647)2.58548522
110regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.58392259
111establishment of viral latency (GO:0019043)2.57814582
112regulation of p38MAPK cascade (GO:1900744)2.57078056
113response to parathyroid hormone (GO:0071107)2.55539398
114DNA strand elongation (GO:0022616)2.55462048
115protein localization to kinetochore (GO:0034501)2.55003499
116lymphangiogenesis (GO:0001946)2.53761199
117positive regulation of catenin import into nucleus (GO:0035413)2.53648124
118regulation of male gonad development (GO:2000018)2.52321522
119vocalization behavior (GO:0071625)2.51870721
120regulation of catenin import into nucleus (GO:0035412)2.50616514
121negative regulation of cell fate commitment (GO:0010454)2.49835811
122positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.48834798
123cranial nerve development (GO:0021545)2.48783387
124cochlea morphogenesis (GO:0090103)2.48610498
125prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.47843948
126response to lead ion (GO:0010288)2.47578125
127regulation of axon guidance (GO:1902667)2.47499982
128notochord development (GO:0030903)2.46702756
129Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.46499411
130regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.46187542
131epithelial cell differentiation involved in kidney development (GO:0035850)2.46174019
132cell proliferation involved in metanephros development (GO:0072203)2.45233358
133cell communication by electrical coupling (GO:0010644)2.45100838
134stress fiber assembly (GO:0043149)2.44864660
135glycine metabolic process (GO:0006544)2.44006831
136mesenchyme morphogenesis (GO:0072132)2.43297946
137syncytium formation by plasma membrane fusion (GO:0000768)2.41770485
138embryonic skeletal joint morphogenesis (GO:0060272)2.41401298
139mitotic metaphase plate congression (GO:0007080)2.36230419
140positive regulation of SMAD protein import into nucleus (GO:0060391)2.35023431
141C4-dicarboxylate transport (GO:0015740)2.34961132
142regulation of stem cell maintenance (GO:2000036)2.30944246
143synaptic vesicle docking involved in exocytosis (GO:0016081)2.28016519
144generation of neurons (GO:0048699)2.27466515
145serine family amino acid catabolic process (GO:0009071)2.25398070
146biotin metabolic process (GO:0006768)2.25123984
147regulation of translational fidelity (GO:0006450)2.23693119
148asymmetric protein localization (GO:0008105)2.22465044
149peptidyl-arginine N-methylation (GO:0035246)2.22228736
150peptidyl-arginine methylation (GO:0018216)2.22228736
151negative regulation of cell fate specification (GO:0009996)2.22210895
152regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.20166471
153IMP biosynthetic process (GO:0006188)2.19048829
154anterior/posterior axis specification, embryo (GO:0008595)2.18911853
155lysine catabolic process (GO:0006554)2.18109620
156lysine metabolic process (GO:0006553)2.18109620
157neuron cell-cell adhesion (GO:0007158)2.17344827
158chromatin remodeling at centromere (GO:0031055)2.16973208
159nucleosome disassembly (GO:0006337)2.16365607
160protein-DNA complex disassembly (GO:0032986)2.16365607
161positive regulation of cell cycle G2/M phase transition (GO:1902751)2.16066714
162positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.16066714
163regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.13984301
164negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.13982936
165proline biosynthetic process (GO:0006561)2.11733852
166DNA strand renaturation (GO:0000733)2.09545730
167regulation of mitotic spindle organization (GO:0060236)2.09323634
168protein localization to chromosome, centromeric region (GO:0071459)2.06922483
169layer formation in cerebral cortex (GO:0021819)2.06201395
170non-canonical Wnt signaling pathway (GO:0035567)2.05981155
171digestive tract morphogenesis (GO:0048546)2.05946178
172regulation of establishment of planar polarity (GO:0090175)2.04564699
173DNA replication initiation (GO:0006270)2.04416964
174adenine nucleotide transport (GO:0051503)2.04207355
175CENP-A containing nucleosome assembly (GO:0034080)2.03257564
176cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.03048242
177cell fate commitment involved in formation of primary germ layer (GO:0060795)2.01124011
178regulation of synaptic vesicle exocytosis (GO:2000300)2.00973845

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.11392098
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.07517853
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.92749574
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.51098515
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.52745876
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.45714997
7CLOCK_20551151_ChIP-Seq_293T_Human3.39053561
8ESR1_21235772_ChIP-Seq_MCF-7_Human3.26889905
9WT1_19549856_ChIP-ChIP_CCG9911_Human3.05626901
10AR_21909140_ChIP-Seq_LNCAP_Human2.91178829
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.74028546
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.57453057
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44788593
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.42387390
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.38327361
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.37966184
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33617525
18EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.25933115
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22518164
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19163485
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.15947748
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14377350
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.12249457
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.12249457
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.12249457
26SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.97717351
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94356938
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92246013
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.91920157
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.91882355
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88207418
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.87186600
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.86777868
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.85704257
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84729222
36NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.82595196
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80462403
38MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.78238375
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74042141
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.73880774
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.71117563
42TCF3_18692474_ChIP-Seq_MEFs_Mouse1.70568106
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69642707
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.67922074
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67698729
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66928840
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.64691223
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.63067357
49* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60704697
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56027710
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55218775
52* XRN2_22483619_ChIP-Seq_HELA_Human1.54271164
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53750621
54EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.52722043
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52430610
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.52179251
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50302058
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50214786
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.50085813
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.49226830
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.48904883
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47036950
63TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46853124
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45205373
65ISL1_27105846_Chip-Seq_CPCs_Mouse1.45184199
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.45078176
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44323643
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44323643
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42895520
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41986553
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41306170
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41056039
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.40705440
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40497050
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40041802
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39511480
77EZH2_22144423_ChIP-Seq_EOC_Human1.39505025
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36438815
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36058616
80TCF3_18692474_ChIP-Seq_MESCs_Mouse1.34907846
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33891565
82* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33265703
83CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33004436
84POU5F1_16518401_ChIP-PET_MESCs_Mouse1.32443614
85CJUN_26792858_Chip-Seq_BT549_Human1.32228156
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31496825
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31436173
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29887562
89RACK7_27058665_Chip-Seq_MCF-7_Human1.28420050
90CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28367696
91UBF1/2_26484160_Chip-Seq_HMECs_Human1.27595900
92TBX20_22080862_ChIP-Seq_HEART_Mouse1.27245712
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.27245712
94GATA1_26923725_Chip-Seq_HPCs_Mouse1.25448527
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24920366
96NANOG_16153702_ChIP-ChIP_HESCs_Human1.24538713
97NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.23840276
98SOX2_20726797_ChIP-Seq_SW620_Human1.23704345
99P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21161301
100ATF3_27146783_Chip-Seq_COLON_Human1.21024885
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20660675
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20612128
103OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20573949
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.19613476
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18905112
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18672983
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18376833
108EED_16625203_ChIP-ChIP_MESCs_Mouse1.16629455
109RARB_27405468_Chip-Seq_BRAIN_Mouse1.14967315
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14212663
111BRD4_25478319_ChIP-Seq_HGPS_Human1.14128805
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14035639
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.13843540
114ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13698863
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13350359
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12087434
117ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12006734
118RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11603471
119EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11603471
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.11042211
121SOX2_18692474_ChIP-Seq_MESCs_Mouse1.10864050
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10719055
123PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09529193
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08991641
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07326590
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07322040
127POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.07305470
128NANOG_18692474_ChIP-Seq_MEFs_Mouse1.07243591
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05918996
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05649528
131SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05627487
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04444967
133DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03748051
134SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02928837
135CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01302014
136KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00701360
137TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00310840
138POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.00146909
139MYC_18555785_ChIP-Seq_MESCs_Mouse0.99551190
140CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98783542
141* TTF2_22483619_ChIP-Seq_HELA_Human0.96919830
142TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96595549
143RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96505927
144SALL1_21062744_ChIP-ChIP_HESCs_Human0.96311629
145* GATA4_25053715_ChIP-Seq_YYC3_Human0.95713764
146TP53_22127205_ChIP-Seq_IMR90_Human0.95638231
147CHD1_26751641_Chip-Seq_LNCaP_Human0.95259703
148OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94724263
149HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94674766
150SOX17_20123909_ChIP-Seq_XEN_Mouse0.93725895
151JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92391178
152PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91713477
153EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91304875
154CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91061985
155NANOG_16518401_ChIP-PET_MESCs_Mouse0.90671391
156KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89999241
157SOX9_26525672_Chip-Seq_HEART_Mouse0.89820204
158CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89548809
159JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88912454
160TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88523772
161NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88013238
162TCF4_18268006_ChIP-ChIP_LS174T_Human0.87471687
163CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87278330
164SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.87211378
165GATA6_25053715_ChIP-Seq_YYC3_Human0.87034747
166TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87030046
167SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86469311
168UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85759864
169HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85305871
170ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84231145

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.57048835
2MP0005623_abnormal_meninges_morphology3.34234225
3MP0000537_abnormal_urethra_morphology3.29571281
4MP0004272_abnormal_basement_membrane2.91675526
5MP0004043_abnormal_pH_regulation2.84846015
6MP0004084_abnormal_cardiac_muscle2.56128973
7MP0009053_abnormal_anal_canal2.53716855
8MP0003942_abnormal_urinary_system2.50935720
9MP0003136_yellow_coat_color2.37483937
10MP0004859_abnormal_synaptic_plasticity2.22359698
11MP0009672_abnormal_birth_weight2.21048943
12MP0000534_abnormal_ureter_morphology2.20357220
13MP0005377_hearing/vestibular/ear_phenot2.10993303
14MP0003878_abnormal_ear_physiology2.10993303
15MP0000579_abnormal_nail_morphology2.08679250
16MP0003941_abnormal_skin_development2.05013439
17MP0000749_muscle_degeneration2.03559856
18MP0004270_analgesia1.98097398
19MP0003315_abnormal_perineum_morphology1.88393445
20MP0003880_abnormal_central_pattern1.88351840
21MP0000733_abnormal_muscle_development1.85479153
22MP0004957_abnormal_blastocyst_morpholog1.82995072
23MP0009250_abnormal_appendicular_skeleto1.77510335
24MP0005423_abnormal_somatic_nervous1.76685305
25MP0003705_abnormal_hypodermis_morpholog1.71160391
26MP0000747_muscle_weakness1.69556258
27MP0006292_abnormal_olfactory_placode1.66541749
28MP0003111_abnormal_nucleus_morphology1.66419546
29MP0003937_abnormal_limbs/digits/tail_de1.66320662
30MP0002736_abnormal_nociception_after1.65457460
31MP0000762_abnormal_tongue_morphology1.63793769
32MP0000383_abnormal_hair_follicle1.63074308
33MP0003693_abnormal_embryo_hatching1.62559580
34MP0003385_abnormal_body_wall1.61953497
35MP0002254_reproductive_system_inflammat1.60786005
36MP0001299_abnormal_eye_distance/1.59015251
37MP0004233_abnormal_muscle_weight1.57685590
38MP0010678_abnormal_skin_adnexa1.57613486
39MP0001984_abnormal_olfaction1.56013061
40MP0010094_abnormal_chromosome_stability1.54945084
41MP0001177_atelectasis1.54326848
42MP0001346_abnormal_lacrimal_gland1.53755050
43MP0009384_cardiac_valve_regurgitation1.53718462
44MP0003115_abnormal_respiratory_system1.52470079
45MP0001958_emphysema1.50933763
46MP0008438_abnormal_cutaneous_collagen1.49174569
47MP0004036_abnormal_muscle_relaxation1.48448753
48MP0001756_abnormal_urination1.48137783
49MP0001486_abnormal_startle_reflex1.48067656
50MP0002249_abnormal_larynx_morphology1.46956682
51MP0000049_abnormal_middle_ear1.44992128
52MP0003123_paternal_imprinting1.42887631
53MP0009643_abnormal_urine_homeostasis1.40116936
54MP0002282_abnormal_trachea_morphology1.39949735
55MP0000778_abnormal_nervous_system1.38470669
56MP0001879_abnormal_lymphatic_vessel1.37268427
57MP0003566_abnormal_cell_adhesion1.35436074
58MP0003755_abnormal_palate_morphology1.31525858
59MP0000428_abnormal_craniofacial_morphol1.31036035
60MP0009379_abnormal_foot_pigmentation1.30599472
61MP0005171_absent_coat_pigmentation1.30101091
62MP0002136_abnormal_kidney_physiology1.28835961
63MP0002932_abnormal_joint_morphology1.27986197
64MP0002734_abnormal_mechanical_nocicepti1.26981168
65MP0002234_abnormal_pharynx_morphology1.26945689
66MP0003077_abnormal_cell_cycle1.25079572
67MP0006054_spinal_hemorrhage1.24556146
68MP0003567_abnormal_fetal_cardiomyocyte1.24503100
69MP0005503_abnormal_tendon_morphology1.23002628
70MP0003890_abnormal_embryonic-extraembry1.22768615
71MP0000566_synostosis1.22635381
72MP0003635_abnormal_synaptic_transmissio1.21306045
73MP0003861_abnormal_nervous_system1.20413266
74MP0004133_heterotaxia1.16945450
75MP0009703_decreased_birth_body1.16856252
76MP0004087_abnormal_muscle_fiber1.16570257
77MP0000163_abnormal_cartilage_morphology1.16357941
78MP0004885_abnormal_endolymph1.15798046
79MP0003950_abnormal_plasma_membrane1.15418786
80MP0005508_abnormal_skeleton_morphology1.14973719
81MP0002233_abnormal_nose_morphology1.14537278
82MP0001968_abnormal_touch/_nociception1.14000983
83MP0003935_abnormal_craniofacial_develop1.13465218
84MP0001849_ear_inflammation1.12737331
85MP0000750_abnormal_muscle_regeneration1.12655267
86MP0005332_abnormal_amino_acid1.11317235
87MP0001730_embryonic_growth_arrest1.10884398
88MP0001293_anophthalmia1.10471277
89MP0002938_white_spotting1.09160569
90MP0000432_abnormal_head_morphology1.08858362
91MP0006138_congestive_heart_failure1.08413802
92MP0003119_abnormal_digestive_system1.08318082
93MP0001529_abnormal_vocalization1.06801737
94MP0008058_abnormal_DNA_repair1.05016584
95MP0002269_muscular_atrophy1.04898253
96MP0002697_abnormal_eye_size1.04891779
97MP0004858_abnormal_nervous_system1.04817283
98MP0000751_myopathy1.04796710
99MP0000678_abnormal_parathyroid_gland1.03949204
100MP0002064_seizures1.03839175
101MP0005394_taste/olfaction_phenotype1.03699579
102MP0005499_abnormal_olfactory_system1.03699579
103MP0002896_abnormal_bone_mineralization1.03023857
104MP0002116_abnormal_craniofacial_bone1.02718158
105MP0002063_abnormal_learning/memory/cond1.01209872
106MP0000013_abnormal_adipose_tissue0.99839369
107MP0001485_abnormal_pinna_reflex0.99458566
108MP0005501_abnormal_skin_physiology0.99237895
109MP0008932_abnormal_embryonic_tissue0.99110439
110MP0003938_abnormal_ear_development0.98988345
111MP0002972_abnormal_cardiac_muscle0.98725198
112MP0001286_abnormal_eye_development0.98705342
113MP0002135_abnormal_kidney_morphology0.98086275
114MP0002152_abnormal_brain_morphology0.98024745
115MP0002084_abnormal_developmental_patter0.97942539
116MP0005187_abnormal_penis_morphology0.97605887
117MP0001672_abnormal_embryogenesis/_devel0.97272709
118MP0005380_embryogenesis_phenotype0.97272709
119MP0008789_abnormal_olfactory_epithelium0.95263949
120MP0010234_abnormal_vibrissa_follicle0.94924540
121MP0010630_abnormal_cardiac_muscle0.94170835
122MP0010368_abnormal_lymphatic_system0.94120174
123MP0002115_abnormal_skeleton_extremities0.93701698
124MP0002796_impaired_skin_barrier0.93634945
125MP0002272_abnormal_nervous_system0.93473508
126MP0002114_abnormal_axial_skeleton0.93406663
127MP0002111_abnormal_tail_morphology0.92654618
128MP0002092_abnormal_eye_morphology0.92283123
129MP0002085_abnormal_embryonic_tissue0.92122649
130MP0003091_abnormal_cell_migration0.90644248
131MP0001765_abnormal_ion_homeostasis0.90395582
132MP0004197_abnormal_fetal_growth/weight/0.90114320
133MP0000955_abnormal_spinal_cord0.89309618
134MP0002098_abnormal_vibrissa_morphology0.88606995
135MP0003283_abnormal_digestive_organ0.88518490
136MP0003690_abnormal_glial_cell0.86088179
137MP0002108_abnormal_muscle_morphology0.85636446
138MP0005620_abnormal_muscle_contractility0.85579491
139MP0003718_maternal_effect0.84839293
140MP0002113_abnormal_skeleton_development0.84411011
141MP0005330_cardiomyopathy0.84338175
142MP0002109_abnormal_limb_morphology0.84045636
143MP0003122_maternal_imprinting0.83726958
144MP0000647_abnormal_sebaceous_gland0.83450906
145MP0002572_abnormal_emotion/affect_behav0.83440513
146MP0000026_abnormal_inner_ear0.83310909
147MP0002925_abnormal_cardiovascular_devel0.81602988
148MP0001697_abnormal_embryo_size0.81381468
149MP0001784_abnormal_fluid_regulation0.81362751
150MP0002653_abnormal_ependyma_morphology0.80850747
151MP0003984_embryonic_growth_retardation0.80777421
152MP0000350_abnormal_cell_proliferation0.80651767
153MP0008569_lethality_at_weaning0.80451522
154MP0001963_abnormal_hearing_physiology0.79584901
155MP0004185_abnormal_adipocyte_glucose0.79431237
156MP0003634_abnormal_glial_cell0.79004620
157MP0003787_abnormal_imprinting0.78904711
158MP0000631_abnormal_neuroendocrine_gland0.78380947
159MP0002088_abnormal_embryonic_growth/wei0.77965607
160MP0002080_prenatal_lethality0.76412359

Predicted human phenotypes

RankGene SetZ-score
1Hypokalemic alkalosis (HP:0001949)5.13797497
2Increased circulating renin level (HP:0000848)4.96354594
3Metabolic alkalosis (HP:0200114)4.82184209
4Focal segmental glomerulosclerosis (HP:0000097)4.49807461
5Hypomagnesemia (HP:0002917)4.34050595
6Mesangial abnormality (HP:0001966)4.14839738
7Glomerulosclerosis (HP:0000096)4.00314863
8Polyuria (HP:0000103)3.94771980
9Aplasia of the musculature (HP:0100854)3.86901130
10Abnormality of chloride homeostasis (HP:0011422)3.81992716
11Hyperactive renin-angiotensin system (HP:0000841)3.67257602
12Renal salt wasting (HP:0000127)3.65907269
13Abnormality of magnesium homeostasis (HP:0004921)3.60635225
14Abnormal urine output (HP:0012590)3.50285870
15Tetany (HP:0001281)3.49338161
16Hyperaldosteronism (HP:0000859)3.23299586
17Pterygium (HP:0001059)3.20505457
18Abnormality of renal excretion (HP:0011036)3.13523375
19Polydipsia (HP:0001959)3.07341652
20Abnormal drinking behavior (HP:0030082)3.07341652
21Muscle fiber splitting (HP:0003555)2.99357673
22Myokymia (HP:0002411)2.92945489
23Hyporeflexia of lower limbs (HP:0002600)2.80074529
24Hypercalciuria (HP:0002150)2.74983344
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.74453725
26Tubular atrophy (HP:0000092)2.74221719
27Hypokalemia (HP:0002900)2.67023850
28Hip contracture (HP:0003273)2.64899419
29Coronal craniosynostosis (HP:0004440)2.63162361
30Muscle fiber inclusion bodies (HP:0100299)2.62108400
31Abnormality of renin-angiotensin system (HP:0000847)2.60028813
32Nemaline bodies (HP:0003798)2.58784409
33Stage 5 chronic kidney disease (HP:0003774)2.56162158
34Morphological abnormality of the inner ear (HP:0011390)2.54820512
35Septo-optic dysplasia (HP:0100842)2.52505533
36Hypoalbuminemia (HP:0003073)2.50406257
37Abnormal albumin level (HP:0012116)2.50406257
38Partial duplication of thumb phalanx (HP:0009944)2.49422007
39Delayed epiphyseal ossification (HP:0002663)2.47229286
40Abnormality of the labia minora (HP:0012880)2.43265378
41Hyperglycinuria (HP:0003108)2.42200299
42Generalized muscle weakness (HP:0003324)2.39898540
43Gout (HP:0001997)2.39170398
44Abnormality of cochlea (HP:0000375)2.38278472
45Type 1 muscle fiber predominance (HP:0003803)2.35299383
46Split foot (HP:0001839)2.30900026
47Lymphangioma (HP:0100764)2.30829403
48Aplasia/Hypoplasia involving the musculature (HP:0001460)2.28438806
49Scapular winging (HP:0003691)2.28007749
50Turricephaly (HP:0000262)2.27607543
51Alkalosis (HP:0001948)2.27078843
52Fetal akinesia sequence (HP:0001989)2.26967997
53Abnormality of the middle phalanges of the toes (HP:0010183)2.25602641
54Popliteal pterygium (HP:0009756)2.25127092
55Amniotic constriction ring (HP:0009775)2.23977626
56Abnormality of placental membranes (HP:0011409)2.23977626
57Calcaneovalgus deformity (HP:0001848)2.21243717
58Bronchomalacia (HP:0002780)2.21004706
59Premature rupture of membranes (HP:0001788)2.17809153
60Deformed tarsal bones (HP:0008119)2.17647643
61High anterior hairline (HP:0009890)2.17441824
62Metaphyseal cupping (HP:0003021)2.15259669
63Neonatal respiratory distress (HP:0002643)2.15171586
64Abnormality of the calf musculature (HP:0001430)2.14566224
65Overriding aorta (HP:0002623)2.08670007
66Ulnar deviation of the wrist (HP:0003049)2.08367249
67Colon cancer (HP:0003003)2.06961995
68Persistence of primary teeth (HP:0006335)2.05015979
69Right ventricular cardiomyopathy (HP:0011663)2.03899710
70Abnormality of the calcaneus (HP:0008364)2.03252997
71Hypoplastic heart (HP:0001961)2.03197094
72Limb-girdle muscle atrophy (HP:0003797)2.03084518
73Aplasia involving bones of the upper limbs (HP:0009823)2.00557011
74Aplasia of the phalanges of the hand (HP:0009802)2.00557011
75Aplasia involving bones of the extremities (HP:0009825)2.00557011
76Spastic diplegia (HP:0001264)2.00356832
77Gowers sign (HP:0003391)1.97877627
78Cortical dysplasia (HP:0002539)1.96496642
79Abnormality of the salivary glands (HP:0010286)1.96453147
80Abnormality of potassium homeostasis (HP:0011042)1.96213196
81Tubulointerstitial fibrosis (HP:0005576)1.95477934
82Partial duplication of the phalanx of hand (HP:0009999)1.95372026
83Knee flexion contracture (HP:0006380)1.95049543
84Shallow orbits (HP:0000586)1.95011510
85Round ear (HP:0100830)1.94744588
86Abnormality of glycine metabolism (HP:0010895)1.93924961
87Abnormality of serine family amino acid metabolism (HP:0010894)1.93924961
88Abnormal auditory evoked potentials (HP:0006958)1.91770343
89Cutaneous syndactyly (HP:0012725)1.91489621
90Renal hypoplasia (HP:0000089)1.90348953
91Cerebral hypomyelination (HP:0006808)1.90313115
92Absent phalangeal crease (HP:0006109)1.89562209
93Increased nuchal translucency (HP:0010880)1.89532430
94Distal arthrogryposis (HP:0005684)1.88890694
95Aplasia/Hypoplasia of the sternum (HP:0006714)1.88104872
96Alacrima (HP:0000522)1.87966899
97Bilateral microphthalmos (HP:0007633)1.87106440
98Metaphyseal dysplasia (HP:0100255)1.86997216
99Abnormal lung lobation (HP:0002101)1.85135922
100Trigonocephaly (HP:0000243)1.84029993
101Esophageal atresia (HP:0002032)1.83774298
102Cutaneous finger syndactyly (HP:0010554)1.83204234
103Selective tooth agenesis (HP:0001592)1.82932345
104Bicornuate uterus (HP:0000813)1.82651266
105Limited hip movement (HP:0008800)1.82312632
106Chondrocalcinosis (HP:0000934)1.80990738
107Duplication of thumb phalanx (HP:0009942)1.80292786
108Abnormality of the foot musculature (HP:0001436)1.79690283
109Broad metatarsal (HP:0001783)1.79541438
110Hyperuricemia (HP:0002149)1.79216915
111Increased purine levels (HP:0004368)1.79216915
112Foot dorsiflexor weakness (HP:0009027)1.78472087
113Exercise-induced muscle cramps (HP:0003710)1.77632854
114Ependymoma (HP:0002888)1.77060321
115Thin bony cortex (HP:0002753)1.73026189
116Down-sloping shoulders (HP:0200021)1.72020224
117Advanced eruption of teeth (HP:0006288)1.70706393
118Multiple enchondromatosis (HP:0005701)1.70585647
119Hyperglycinemia (HP:0002154)1.69363960
120Reticulocytopenia (HP:0001896)1.68560082
121Absent septum pellucidum (HP:0001331)1.68352834
122Abnormality of Sharpey fibers (HP:0100685)1.68097596
123Distal lower limb muscle weakness (HP:0009053)1.67741761
124Abnormality of the septum pellucidum (HP:0007375)1.67507848
125Choanal stenosis (HP:0000452)1.67327187
126Myelomeningocele (HP:0002475)1.67043243
127Arnold-Chiari malformation (HP:0002308)1.66891376
128Abnormality of sodium homeostasis (HP:0010931)1.66885810
129EMG: myopathic abnormalities (HP:0003458)1.66789724
130Nephroblastoma (Wilms tumor) (HP:0002667)1.66183660
131Malignant hyperthermia (HP:0002047)1.65566762
132Chromosomal breakage induced by crosslinking agents (HP:0003221)1.65339179
133Facial cleft (HP:0002006)1.64472846
134Ankle contracture (HP:0006466)1.63648939
135Neonatal short-limb short stature (HP:0008921)1.63633453
136Action tremor (HP:0002345)1.63325149
137Abnormality of the diencephalon (HP:0010662)1.63116576
138Nephrocalcinosis (HP:0000121)1.61097663
139Maternal diabetes (HP:0009800)1.60506343
140Thin ribs (HP:0000883)1.60164460
141Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59844134
142Short 4th metacarpal (HP:0010044)1.59844134
143Abnormal finger flexion creases (HP:0006143)1.59176711
144Back pain (HP:0003418)1.58619777
145Broad thumb (HP:0011304)1.58140923
146Anophthalmia (HP:0000528)1.58126688
147Abnormality of the lacrimal duct (HP:0011481)1.57807846
148Nonprogressive disorder (HP:0003680)1.57440918
149Adrenal overactivity (HP:0002717)1.57301262
150Tarsal synostosis (HP:0008368)1.56665565
151Insomnia (HP:0100785)1.55070635
152Omphalocele (HP:0001539)1.54183490
153Hepatoblastoma (HP:0002884)1.53872841
154Exostoses (HP:0100777)1.53477349
155Birth length less than 3rd percentile (HP:0003561)1.53437399
156Megalencephaly (HP:0001355)1.52714904
157Embryonal renal neoplasm (HP:0011794)1.52445366
158Peripheral hypomyelination (HP:0007182)1.52022679
159Bifid scrotum (HP:0000048)1.50360668
160Ankle clonus (HP:0011448)1.48997704
161Medulloblastoma (HP:0002885)1.48495378
162Absent eyebrow (HP:0002223)1.47873307
163Absent radius (HP:0003974)1.47667118
164Chromsome breakage (HP:0040012)1.46895299
165Hyperacusis (HP:0010780)1.42737952
166Hemivertebrae (HP:0002937)1.41703070
167Absent forearm bone (HP:0003953)1.41634215
168Aplasia involving forearm bones (HP:0009822)1.41634215
169Elfin facies (HP:0004428)1.39932294
170Stenosis of the external auditory canal (HP:0000402)1.39743863
171Hypoglycemic seizures (HP:0002173)1.39527838
172Absent eyelashes (HP:0000561)1.39470698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.46910805
2OXSR14.52457859
3WNK34.33405894
4STK393.78969170
5EPHB23.29820765
6VRK22.63216359
7PAK42.62999369
8TRIB32.26402743
9LATS12.23270691
10EPHA42.18237852
11STK38L2.15872925
12LIMK12.12266827
13DDR22.09206094
14OBSCN1.97556777
15SRPK11.96358090
16TTN1.95330869
17TSSK61.93541362
18SMG11.90860773
19LRRK21.86330959
20NTRK21.58228489
21NEK11.54007536
22EEF2K1.46424418
23TAF11.43226110
24FGFR11.40225138
25MKNK21.34215429
26FER1.32056386
27ROCK21.27922885
28MKNK11.25701717
29EPHB11.22894992
30MST41.22871593
31TESK11.21968115
32ILK1.20531243
33ROCK11.15286411
34BCR1.15225080
35PTK21.13802564
36MAP3K91.13233126
37PDGFRA1.12513634
38WNK11.11695948
39PTK61.11679679
40NEK61.09547222
41MYLK1.05493043
42PAK31.05092000
43BRSK21.04848108
44TGFBR11.03071185
45DYRK1B1.01389234
46MET1.00096537
47STK100.98655789
48PAK60.98566794
49ALK0.98421024
50CAMK1D0.98414740
51SGK20.97811674
52BMX0.95932326
53PAK20.94973526
54CDK190.94769216
55LATS20.94358516
56EPHA20.92315601
57CAMK1G0.91715071
58TNIK0.90526038
59FGFR20.90311733
60MAP3K80.89333869
61AKT20.87946588
62PLK10.87053279
63SGK2230.85303320
64SGK4940.85303320
65MINK10.84040210
66MARK10.83703277
67NEK90.83700563
68ERBB30.83551772
69PRKD30.82527289
70TRPM70.81672547
71PLK40.80344820
72NTRK30.77698580
73STK30.77591126
74CHEK20.75731480
75DAPK10.74971870
76ATR0.72654797
77RIPK10.72152549
78CASK0.71522990
79RPS6KB20.71279175
80CAMK2G0.70350939
81CDK70.70332338
82NME10.69058059
83PNCK0.68741083
84BUB10.68718635
85MAP2K10.68602692
86SGK30.68482695
87TESK20.67892911
88PLK20.66982470
89MOS0.66400854
90CSNK1G10.66084756
91CDK60.64102750
92MTOR0.63078794
93MELK0.62420618
94AURKB0.62275829
95MUSK0.61845322
96CDK140.60478132
97PDK20.60254328
98CDC70.60107457
99PKN20.59924520
100CSNK1G20.59620150
101WEE10.59279034
102BCKDK0.59142417
103CHEK10.57992421
104TGFBR20.57243611
105CSNK1G30.53970946
106CSNK1A1L0.53331577
107CSNK1E0.53090534
108PAK10.52855245
109MAPKAPK50.52374908
110CDK150.51907677
111TTK0.51658314
112PBK0.51607176
113PRKDC0.51393725
114CDK10.50848912
115BRAF0.50823356
116GSK3A0.50597433
117RPS6KA40.50389080
118AURKA0.50048475
119CDK180.49961620
120VRK10.49875533
121ICK0.49803933
122TYRO30.48531530
123MAPK100.48041533
124TIE10.47793808
125ATM0.47360756
126CDK20.47187535
127PLK30.47160590
128STK160.46386614
129CAMK2D0.46178548
130CDK11A0.44595211
131BRSK10.43712415
132PRKCG0.43682943
133EIF2AK10.43550132
134ERBB20.41436235
135PIK3CG0.40275283
136MAP2K20.39718991
137KSR10.38342182
138PDK30.36942177
139PDK40.36942177
140CAMK2B0.34884773
141UHMK10.34809222
142PRKCI0.33746879
143DMPK0.32761191
144DYRK20.32185655
145PTK2B0.31313851
146PKN10.31298283
147ERBB40.31214941
148CDC42BPA0.31037644
149MAP3K100.30162106
150MAP3K70.29722827
151PIK3CA0.29377665
152DYRK30.29344482
153NTRK10.29057089

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.88201667
2Hippo signaling pathway_Homo sapiens_hsa043902.67045547
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.62213480
4Basal cell carcinoma_Homo sapiens_hsa052172.52704614
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43043076
6Tight junction_Homo sapiens_hsa045302.37420345
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.35066298
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.28827130
9Focal adhesion_Homo sapiens_hsa045102.14477661
10Hedgehog signaling pathway_Homo sapiens_hsa043402.08314387
11Dilated cardiomyopathy_Homo sapiens_hsa054142.05329658
12Vitamin B6 metabolism_Homo sapiens_hsa007502.04499137
13Bladder cancer_Homo sapiens_hsa052192.00367384
14Small cell lung cancer_Homo sapiens_hsa052221.98889813
15Proteoglycans in cancer_Homo sapiens_hsa052051.86079839
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83414918
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79967453
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78233352
19Adherens junction_Homo sapiens_hsa045201.76311971
20Protein digestion and absorption_Homo sapiens_hsa049741.70724815
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67226360
22Base excision repair_Homo sapiens_hsa034101.65832873
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.56107303
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54320570
25TGF-beta signaling pathway_Homo sapiens_hsa043501.53472732
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52325912
27Propanoate metabolism_Homo sapiens_hsa006401.50028496
28Axon guidance_Homo sapiens_hsa043601.49120806
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42882434
30Pyruvate metabolism_Homo sapiens_hsa006201.41274645
31Glutathione metabolism_Homo sapiens_hsa004801.36382127
32Thyroid hormone synthesis_Homo sapiens_hsa049181.35592305
33MicroRNAs in cancer_Homo sapiens_hsa052061.34147671
34beta-Alanine metabolism_Homo sapiens_hsa004101.27985300
35mRNA surveillance pathway_Homo sapiens_hsa030151.25642103
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.25103039
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21529425
38Folate biosynthesis_Homo sapiens_hsa007901.20686455
39Cardiac muscle contraction_Homo sapiens_hsa042601.20395927
40RNA polymerase_Homo sapiens_hsa030201.20132773
41Ribosome_Homo sapiens_hsa030101.19963671
42Carbon metabolism_Homo sapiens_hsa012001.17670296
43Butanoate metabolism_Homo sapiens_hsa006501.15067111
44Non-homologous end-joining_Homo sapiens_hsa034501.14866269
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14030271
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13928120
47Cell cycle_Homo sapiens_hsa041101.13381273
48Mineral absorption_Homo sapiens_hsa049781.12050738
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11975644
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07597057
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.07240156
52Arginine and proline metabolism_Homo sapiens_hsa003301.06389053
53Homologous recombination_Homo sapiens_hsa034401.04298755
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04297425
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02334127
56Pathways in cancer_Homo sapiens_hsa052001.00571063
57Amoebiasis_Homo sapiens_hsa051460.99707448
58Oocyte meiosis_Homo sapiens_hsa041140.99335076
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98969255
60Melanoma_Homo sapiens_hsa052180.98904790
61Sulfur metabolism_Homo sapiens_hsa009200.95874784
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95284009
63Renal cell carcinoma_Homo sapiens_hsa052110.94394194
64Prostate cancer_Homo sapiens_hsa052150.94095114
65Autoimmune thyroid disease_Homo sapiens_hsa053200.93923458
66Biosynthesis of amino acids_Homo sapiens_hsa012300.91698973
67Nicotine addiction_Homo sapiens_hsa050330.91106691
68Wnt signaling pathway_Homo sapiens_hsa043100.90551942
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88111896
70Gastric acid secretion_Homo sapiens_hsa049710.88055224
71Fatty acid elongation_Homo sapiens_hsa000620.86983465
72Synaptic vesicle cycle_Homo sapiens_hsa047210.85250911
73Arachidonic acid metabolism_Homo sapiens_hsa005900.81652920
74Steroid biosynthesis_Homo sapiens_hsa001000.81495209
75Lysine degradation_Homo sapiens_hsa003100.81222287
76Fatty acid biosynthesis_Homo sapiens_hsa000610.80303816
77Nucleotide excision repair_Homo sapiens_hsa034200.80038818
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79241627
79Melanogenesis_Homo sapiens_hsa049160.77398382
80Spliceosome_Homo sapiens_hsa030400.76965611
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76836733
82Thyroid cancer_Homo sapiens_hsa052160.76426400
83Glutamatergic synapse_Homo sapiens_hsa047240.75806117
84Fanconi anemia pathway_Homo sapiens_hsa034600.75572684
85Chronic myeloid leukemia_Homo sapiens_hsa052200.73865623
86Rap1 signaling pathway_Homo sapiens_hsa040150.73264298
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73115411
88Renin-angiotensin system_Homo sapiens_hsa046140.72615176
89Endometrial cancer_Homo sapiens_hsa052130.71937179
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70415957
91Viral myocarditis_Homo sapiens_hsa054160.70363348
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70136964
93Sulfur relay system_Homo sapiens_hsa041220.69694219
94p53 signaling pathway_Homo sapiens_hsa041150.69516193
95Vitamin digestion and absorption_Homo sapiens_hsa049770.68096353
96Pancreatic cancer_Homo sapiens_hsa052120.67237837
97Fatty acid degradation_Homo sapiens_hsa000710.65431390
98Pentose phosphate pathway_Homo sapiens_hsa000300.64699845
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.64591158
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64286235
101Arginine biosynthesis_Homo sapiens_hsa002200.64150351
102Fatty acid metabolism_Homo sapiens_hsa012120.62558421
103Huntingtons disease_Homo sapiens_hsa050160.61891057
104RNA transport_Homo sapiens_hsa030130.61764949
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61289064
106Notch signaling pathway_Homo sapiens_hsa043300.60562841
107Circadian entrainment_Homo sapiens_hsa047130.56827610
108GABAergic synapse_Homo sapiens_hsa047270.56495310
109HTLV-I infection_Homo sapiens_hsa051660.55677730
110Oxidative phosphorylation_Homo sapiens_hsa001900.55360158
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55038949
112Long-term potentiation_Homo sapiens_hsa047200.54828128
113HIF-1 signaling pathway_Homo sapiens_hsa040660.54685944
114AMPK signaling pathway_Homo sapiens_hsa041520.52681274
115Mismatch repair_Homo sapiens_hsa034300.52100509
116Parkinsons disease_Homo sapiens_hsa050120.51546815
117Amphetamine addiction_Homo sapiens_hsa050310.50160013
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49954615
119Ovarian steroidogenesis_Homo sapiens_hsa049130.49174356
120RNA degradation_Homo sapiens_hsa030180.48906155
121Purine metabolism_Homo sapiens_hsa002300.48561613
122Glioma_Homo sapiens_hsa052140.48493862
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47161355
124Estrogen signaling pathway_Homo sapiens_hsa049150.47089291
125DNA replication_Homo sapiens_hsa030300.46636672
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46514354
127Pyrimidine metabolism_Homo sapiens_hsa002400.45959040
128Glucagon signaling pathway_Homo sapiens_hsa049220.45268677
129Sphingolipid metabolism_Homo sapiens_hsa006000.44904577
130Ether lipid metabolism_Homo sapiens_hsa005650.44900783
131Histidine metabolism_Homo sapiens_hsa003400.44365528
132Dopaminergic synapse_Homo sapiens_hsa047280.43979032
133Vibrio cholerae infection_Homo sapiens_hsa051100.43815097
134Basal transcription factors_Homo sapiens_hsa030220.43558037
135Insulin secretion_Homo sapiens_hsa049110.42518785
136Linoleic acid metabolism_Homo sapiens_hsa005910.42368856
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42252956
138Ras signaling pathway_Homo sapiens_hsa040140.42026262
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42024590
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41594048
141Bile secretion_Homo sapiens_hsa049760.40992797
142ErbB signaling pathway_Homo sapiens_hsa040120.40738235
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39039946
144One carbon pool by folate_Homo sapiens_hsa006700.38821826
145Proteasome_Homo sapiens_hsa030500.36522252
146Gap junction_Homo sapiens_hsa045400.35182771
147VEGF signaling pathway_Homo sapiens_hsa043700.35086344
148FoxO signaling pathway_Homo sapiens_hsa040680.34106993

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