AIFM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine metabolic process (GO:0006558)5.82740946
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.82740946
3L-phenylalanine catabolic process (GO:0006559)5.81318771
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.81318771
5glyoxylate metabolic process (GO:0046487)5.39374553
6lysine catabolic process (GO:0006554)5.33363102
7lysine metabolic process (GO:0006553)5.33363102
8aromatic amino acid family catabolic process (GO:0009074)5.30865313
9sulfur amino acid catabolic process (GO:0000098)5.21010884
10kynurenine metabolic process (GO:0070189)4.98101260
11indole-containing compound catabolic process (GO:0042436)4.88616442
12indolalkylamine catabolic process (GO:0046218)4.88616442
13tryptophan catabolic process (GO:0006569)4.88616442
14cysteine metabolic process (GO:0006534)4.87351106
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.72284438
16serine family amino acid catabolic process (GO:0009071)4.67321944
17alpha-linolenic acid metabolic process (GO:0036109)4.65068979
18coenzyme catabolic process (GO:0009109)4.62883368
19tryptophan metabolic process (GO:0006568)4.60936202
20cellular modified amino acid catabolic process (GO:0042219)4.53811245
21glycine metabolic process (GO:0006544)4.52482349
22bile acid biosynthetic process (GO:0006699)4.44692172
23amino-acid betaine metabolic process (GO:0006577)4.32253339
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.25249298
25homocysteine metabolic process (GO:0050667)4.23386611
26serine family amino acid biosynthetic process (GO:0009070)4.19674198
27urea metabolic process (GO:0019627)4.19394282
28urea cycle (GO:0000050)4.19394282
29serine family amino acid metabolic process (GO:0009069)4.18562209
30negative regulation of fibrinolysis (GO:0051918)4.08056943
31alpha-amino acid catabolic process (GO:1901606)4.08038806
32NADH metabolic process (GO:0006734)4.05637139
33branched-chain amino acid catabolic process (GO:0009083)4.02609011
34epoxygenase P450 pathway (GO:0019373)3.99924110
35nuclear pore complex assembly (GO:0051292)3.97196198
36cellular amino acid catabolic process (GO:0009063)3.96920539
37valine metabolic process (GO:0006573)3.94345089
38aromatic amino acid family metabolic process (GO:0009072)3.91571517
39regulation of protein activation cascade (GO:2000257)3.88865920
40acetyl-CoA metabolic process (GO:0006084)3.86575120
41aspartate family amino acid catabolic process (GO:0009068)3.86315879
42nitrogen cycle metabolic process (GO:0071941)3.85856994
43high-density lipoprotein particle remodeling (GO:0034375)3.84081056
44peptidyl-glutamic acid carboxylation (GO:0017187)3.83562152
45protein carboxylation (GO:0018214)3.83562152
462-oxoglutarate metabolic process (GO:0006103)3.81846594
47complement activation, alternative pathway (GO:0006957)3.80572712
48ethanol oxidation (GO:0006069)3.79275152
49bile acid metabolic process (GO:0008206)3.78204201
50biotin metabolic process (GO:0006768)3.76265566
51cellular ketone body metabolic process (GO:0046950)3.74812940
52DNA strand elongation involved in DNA replication (GO:0006271)3.72957201
53regulation of fibrinolysis (GO:0051917)3.72648715
54regulation of triglyceride catabolic process (GO:0010896)3.72112957
55formation of translation preinitiation complex (GO:0001731)3.71643926
56fatty acid beta-oxidation (GO:0006635)3.70924336
57regulation of translational fidelity (GO:0006450)3.67517790
58branched-chain amino acid metabolic process (GO:0009081)3.64445353
59regulation of complement activation (GO:0030449)3.64218017
60daunorubicin metabolic process (GO:0044597)3.60740606
61polyketide metabolic process (GO:0030638)3.60740606
62doxorubicin metabolic process (GO:0044598)3.60740606
63short-chain fatty acid metabolic process (GO:0046459)3.59127807
64heme transport (GO:0015886)3.58607123
65DNA strand elongation (GO:0022616)3.58008655
66ribosome assembly (GO:0042255)3.56697973
67triglyceride homeostasis (GO:0070328)3.55612904
68acylglycerol homeostasis (GO:0055090)3.55612904
69cofactor catabolic process (GO:0051187)3.54443104
70oxidative phosphorylation (GO:0006119)3.53774355
71carnitine metabolic process (GO:0009437)3.53451812
72organic acid catabolic process (GO:0016054)3.52641347
73carboxylic acid catabolic process (GO:0046395)3.52641347
74negative regulation of cholesterol transport (GO:0032375)3.52206963
75negative regulation of sterol transport (GO:0032372)3.52206963
76fatty acid oxidation (GO:0019395)3.52105399
77nuclear pore organization (GO:0006999)3.50194386
78DNA replication checkpoint (GO:0000076)3.49047026
79imidazole-containing compound metabolic process (GO:0052803)3.44936469
80oxaloacetate metabolic process (GO:0006107)3.44325788
81purine nucleobase biosynthetic process (GO:0009113)3.44276976
82lipid oxidation (GO:0034440)3.43593255
83drug metabolic process (GO:0017144)3.43425705
84tyrosine metabolic process (GO:0006570)3.42664419
85mitotic chromosome condensation (GO:0007076)3.38155191
86primary alcohol catabolic process (GO:0034310)3.37998028
87indolalkylamine metabolic process (GO:0006586)3.37568754
88folic acid-containing compound biosynthetic process (GO:0009396)3.35887664
89protein-lipid complex remodeling (GO:0034368)3.35111223
90macromolecular complex remodeling (GO:0034367)3.35111223
91plasma lipoprotein particle remodeling (GO:0034369)3.35111223
92nucleobase biosynthetic process (GO:0046112)3.35024721
93benzene-containing compound metabolic process (GO:0042537)3.33784987
94fatty acid catabolic process (GO:0009062)3.33679330
95IMP biosynthetic process (GO:0006188)3.33281764
96DNA unwinding involved in DNA replication (GO:0006268)3.33045043
97L-serine metabolic process (GO:0006563)3.31685903
98telomere maintenance via semi-conservative replication (GO:0032201)3.30723108
99urate metabolic process (GO:0046415)3.30715024
100plasma lipoprotein particle clearance (GO:0034381)3.30685172
101reverse cholesterol transport (GO:0043691)3.27862301
102regulation of cholesterol esterification (GO:0010872)3.27790196
103glutamate metabolic process (GO:0006536)3.26407668
104proline biosynthetic process (GO:0006561)3.26116285
105negative regulation of fatty acid biosynthetic process (GO:0045717)3.25362603
106aldehyde catabolic process (GO:0046185)3.24980243
107monocarboxylic acid catabolic process (GO:0072329)3.24449048
108drug catabolic process (GO:0042737)3.23651469
109mitotic sister chromatid segregation (GO:0000070)3.22645701
110DNA replication initiation (GO:0006270)3.20806240
111bile acid and bile salt transport (GO:0015721)3.20725885
112tricarboxylic acid cycle (GO:0006099)3.20722247
113tetrahydrofolate metabolic process (GO:0046653)3.20636155
114tRNA aminoacylation for protein translation (GO:0006418)3.20048409
115ketone body metabolic process (GO:1902224)3.19916912
116regulation of mitochondrial translation (GO:0070129)3.17839066
117cellular biogenic amine catabolic process (GO:0042402)3.16744823
118amine catabolic process (GO:0009310)3.16744823
119nucleobase-containing small molecule interconversion (GO:0015949)3.16665733
120cellular glucuronidation (GO:0052695)3.16130100
121proteasome assembly (GO:0043248)3.15469413
122mitotic metaphase plate congression (GO:0007080)3.15231188
123drug transmembrane transport (GO:0006855)3.14188958
124mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13691787
125aminoglycoside antibiotic metabolic process (GO:0030647)3.11146963
126tRNA aminoacylation (GO:0043039)3.11058526
127amino acid activation (GO:0043038)3.11058526
128mitotic nuclear envelope disassembly (GO:0007077)3.10838373
129flavonoid metabolic process (GO:0009812)3.10671731
130protein maturation by protein folding (GO:0022417)3.10252570
131IMP metabolic process (GO:0046040)3.08718062
132dicarboxylic acid biosynthetic process (GO:0043650)3.07629763
133arginine metabolic process (GO:0006525)3.03767731
134regulation of helicase activity (GO:0051095)3.02869587
135transcription from mitochondrial promoter (GO:0006390)3.02298777
136pore complex assembly (GO:0046931)3.01306029
137pteridine-containing compound biosynthetic process (GO:0042559)2.97576243
138establishment of integrated proviral latency (GO:0075713)2.96110911
139protein localization to chromosome, centromeric region (GO:0071459)2.91124476
140protein localization to kinetochore (GO:0034501)2.89374492
141folic acid metabolic process (GO:0046655)2.86387337
142negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85810180
143sister chromatid segregation (GO:0000819)2.82800197
144viral mRNA export from host cell nucleus (GO:0046784)2.81660916
145mitochondrial RNA metabolic process (GO:0000959)2.80785266
146membrane disassembly (GO:0030397)2.79809525
147nuclear envelope disassembly (GO:0051081)2.79809525
148anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78812609
149regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78641688
150folic acid-containing compound metabolic process (GO:0006760)2.77496018
151regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.77230948
152COPI coating of Golgi vesicle (GO:0048205)2.77050119
153Golgi transport vesicle coating (GO:0048200)2.77050119
154gluconeogenesis (GO:0006094)2.75322527
155telomere maintenance via recombination (GO:0000722)2.71927810
156maturation of 5.8S rRNA (GO:0000460)2.71214802
157positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71090720
158proline metabolic process (GO:0006560)2.70770003
159negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.70383853
160negative regulation of ligase activity (GO:0051352)2.70383853
161ribosome biogenesis (GO:0042254)2.70313783
162monosaccharide biosynthetic process (GO:0046364)2.67889483
163respiratory electron transport chain (GO:0022904)2.63166219
164DNA damage response, detection of DNA damage (GO:0042769)2.61574525
165pteridine-containing compound metabolic process (GO:0042558)2.61474657
166ribosomal large subunit biogenesis (GO:0042273)2.61351438
167regulation of cellular amino acid metabolic process (GO:0006521)2.61061273
168metaphase plate congression (GO:0051310)2.61024970
169ribonucleoprotein complex biogenesis (GO:0022613)2.59461955
170hexose biosynthetic process (GO:0019319)2.58823276
171ATP synthesis coupled proton transport (GO:0015986)2.57868236
172energy coupled proton transport, down electrochemical gradient (GO:0015985)2.57868236
173mitotic recombination (GO:0006312)2.57397748
174telomere maintenance via telomere lengthening (GO:0010833)2.55958644
175electron transport chain (GO:0022900)2.55904759
176ribosomal small subunit biogenesis (GO:0042274)2.54142507
177non-recombinational repair (GO:0000726)2.53500570
178double-strand break repair via nonhomologous end joining (GO:0006303)2.53500570
179regulation of translational termination (GO:0006449)2.51773970
180aerobic respiration (GO:0009060)2.51168442
181maturation of SSU-rRNA (GO:0030490)2.50587892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.34327489
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.96801870
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.88274826
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.54228101
5E2F7_22180533_ChIP-Seq_HELA_Human4.10993125
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.82366953
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.67158951
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.31765412
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21020969
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.85867941
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.83999014
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59567838
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.37564746
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35238002
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35063769
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31225749
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.29764920
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.25820670
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.25820670
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.25820670
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23953841
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07781069
23STAT3_1855785_ChIP-Seq_MESCs_Mouse1.95378939
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.94758987
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92202550
26AR_21909140_ChIP-Seq_LNCAP_Human1.90478803
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87648363
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.84300502
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78467794
30TTF2_22483619_ChIP-Seq_HELA_Human1.77236390
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74478813
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71450509
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.71155293
34* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.69193675
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67799425
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.67235865
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61686996
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57329509
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56332829
40NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.55335048
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.51829464
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48581482
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48393659
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48042619
45ZNF263_19887448_ChIP-Seq_K562_Human1.46868562
46ELK1_19687146_ChIP-ChIP_HELA_Human1.45213429
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45113856
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43215175
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42631578
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40607905
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40193053
52CLOCK_20551151_ChIP-Seq_293T_Human1.39625436
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38799658
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38272471
55TFEB_21752829_ChIP-Seq_HELA_Human1.35483183
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34169908
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31676045
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31280006
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26963074
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25745424
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.22848272
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21576947
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21323451
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.20470029
65SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.19465495
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19348570
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17127776
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16638962
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15836274
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12955649
71TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11830711
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11416521
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10696586
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10304704
75TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09883513
76* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09676739
77TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08740991
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08323221
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07533701
80OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06436403
81CIITA_25753668_ChIP-Seq_RAJI_Human1.06032224
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.05538698
83SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05414746
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04348478
85NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03976556
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03566518
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02852253
88XRN2_22483619_ChIP-Seq_HELA_Human1.01707094
89DCP1A_22483619_ChIP-Seq_HELA_Human1.01284733
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00130344
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.99760876
92MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99747207
93* FOXP3_21729870_ChIP-Seq_TREG_Human0.99329317
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97644443
95GABP_19822575_ChIP-Seq_HepG2_Human0.96576854
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95682526
97ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94814602
98RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94671527
99IRF1_19129219_ChIP-ChIP_H3396_Human0.94452577
100YY1_21170310_ChIP-Seq_MESCs_Mouse0.93792088
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93750071
102HNF4A_19822575_ChIP-Seq_HepG2_Human0.93310319
103NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93125960
104GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91217821
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91184773
106* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91027056
107MYC_22102868_ChIP-Seq_BL_Human0.90821784
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90712126
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90365985
110* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89411612
111KDM5A_27292631_Chip-Seq_BREAST_Human0.89178729
112KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88932133
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86954637
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86364263
115CHD1_26751641_Chip-Seq_LNCaP_Human0.85561208
116TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85015419
117SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83885574
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.82289187
119GATA1_22025678_ChIP-Seq_K562_Human0.82261549
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82179401
121POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.82178430
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81816345
123POU5F1_16518401_ChIP-PET_MESCs_Mouse0.81094233
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79688102
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79632568
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79579963
127TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79224041
128RARG_19884340_ChIP-ChIP_MEFs_Mouse0.76421806
129E2F1_21310950_ChIP-Seq_MCF-7_Human0.76214224
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.75315615
131TP63_19390658_ChIP-ChIP_HaCaT_Human0.75060746
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74901009
133VDR_23849224_ChIP-Seq_CD4+_Human0.74826186
134SOX2_18692474_ChIP-Seq_MESCs_Mouse0.74421418
135KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.74380786
136GATA4_25053715_ChIP-Seq_YYC3_Human0.72671928
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72339807
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71778204
139* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.70659401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.58558131
2MP0005360_urolithiasis6.35443776
3MP0005085_abnormal_gallbladder_physiolo5.13877533
4MP0005365_abnormal_bile_salt4.90515065
5MP0003806_abnormal_nucleotide_metabolis4.79550260
6MP0008875_abnormal_xenobiotic_pharmacok4.11569250
7MP0003252_abnormal_bile_duct3.12790875
8MP0010329_abnormal_lipoprotein_level2.76285962
9MP0008058_abnormal_DNA_repair2.75110798
10MP0005332_abnormal_amino_acid2.71536860
11MP0003011_delayed_dark_adaptation2.41821028
12MP0009840_abnormal_foam_cell2.35955354
13MP0008932_abnormal_embryonic_tissue2.32307889
14MP0003705_abnormal_hypodermis_morpholog2.21365404
15MP0000372_irregular_coat_pigmentation2.17409715
16MP0005083_abnormal_biliary_tract2.06258105
17MP0003195_calcinosis2.06177599
18MP0004233_abnormal_muscle_weight2.06064325
19MP0001666_abnormal_nutrient_absorption1.98933280
20MP0000609_abnormal_liver_physiology1.96631603
21* MP0005319_abnormal_enzyme/_coenzyme1.90603300
22MP0008007_abnormal_cellular_replicative1.88233653
23MP0004019_abnormal_vitamin_homeostasis1.83616986
24MP0004264_abnormal_extraembryonic_tissu1.83053869
25MP0003786_premature_aging1.74789482
26* MP0006036_abnormal_mitochondrial_physio1.72912527
27MP0002877_abnormal_melanocyte_morpholog1.69373740
28MP0002254_reproductive_system_inflammat1.65318067
29MP0003191_abnormal_cellular_cholesterol1.64310505
30MP0002118_abnormal_lipid_homeostasis1.59734887
31* MP0006035_abnormal_mitochondrial_morpho1.57738999
32* MP0003186_abnormal_redox_activity1.57534037
33MP0010307_abnormal_tumor_latency1.51009068
34MP0010234_abnormal_vibrissa_follicle1.44777784
35MP0004957_abnormal_blastocyst_morpholog1.40509312
36MP0005058_abnormal_lysosome_morphology1.39911913
37MP0009643_abnormal_urine_homeostasis1.39289790
38MP0000751_myopathy1.39272909
39MP0005266_abnormal_metabolism1.36864409
40MP0000598_abnormal_liver_morphology1.31792515
41* MP0005584_abnormal_enzyme/coenzyme_acti1.30951003
42MP0001764_abnormal_homeostasis1.25011348
43MP0002138_abnormal_hepatobiliary_system1.21423217
44MP0009697_abnormal_copulation1.18953326
45MP0004043_abnormal_pH_regulation1.17832403
46MP0004147_increased_porphyrin_level1.15423375
47MP0005451_abnormal_body_composition1.14138348
48MP0005670_abnormal_white_adipose1.13261579
49MP0003941_abnormal_skin_development1.11043686
50MP0002332_abnormal_exercise_endurance1.10485965
51* MP0000313_abnormal_cell_death1.08923833
52MP0003656_abnormal_erythrocyte_physiolo1.08743617
53MP0000747_muscle_weakness1.07546353
54MP0001727_abnormal_embryo_implantation1.07434004
55MP0003868_abnormal_feces_composition1.06406963
56MP0003890_abnormal_embryonic-extraembry1.04720454
57MP0008057_abnormal_DNA_replication0.99240345
58MP0010352_gastrointestinal_tract_polyps0.98506492
59MP0004084_abnormal_cardiac_muscle0.97648680
60MP0005376_homeostasis/metabolism_phenot0.95704052
61* MP0002088_abnormal_embryonic_growth/wei0.95244957
62MP0004185_abnormal_adipocyte_glucose0.95173721
63* MP0003984_embryonic_growth_retardation0.94359331
64* MP0005330_cardiomyopathy0.93883483
65MP0005666_abnormal_adipose_tissue0.91212683
66* MP0005380_embryogenesis_phenotype0.90726826
67* MP0001672_abnormal_embryogenesis/_devel0.90726826
68MP0002090_abnormal_vision0.90686257
69MP0004782_abnormal_surfactant_physiolog0.89546366
70* MP0002972_abnormal_cardiac_muscle0.89427724
71* MP0002269_muscular_atrophy0.89048283
72MP0004145_abnormal_muscle_electrophysio0.88228348
73* MP0008775_abnormal_heart_ventricle0.86992886
74MP0005636_abnormal_mineral_homeostasis0.86014436
75MP0005395_other_phenotype0.85320394
76MP0002837_dystrophic_cardiac_calcinosis0.84382145
77MP0001881_abnormal_mammary_gland0.83975230
78MP0002084_abnormal_developmental_patter0.83788227
79MP0010368_abnormal_lymphatic_system0.83217653
80* MP0002085_abnormal_embryonic_tissue0.82989874
81MP0003137_abnormal_impulse_conducting0.82446535
82MP0002970_abnormal_white_adipose0.80306414
83MP0001730_embryonic_growth_arrest0.79726150
84MP0008995_early_reproductive_senescence0.79709079
85MP0005075_abnormal_melanosome_morpholog0.77821377
86* MP0009763_increased_sensitivity_to0.77516226
87MP0001756_abnormal_urination0.76108716
88MP0005501_abnormal_skin_physiology0.74805581
89* MP0000749_muscle_degeneration0.74203088
90MP0002163_abnormal_gland_morphology0.73519594
91MP0002210_abnormal_sex_determination0.73386195
92MP0009053_abnormal_anal_canal0.72882080
93MP0002086_abnormal_extraembryonic_tissu0.72022426
94MP0004130_abnormal_muscle_cell0.70850514
95MP0005647_abnormal_sex_gland0.70333498
96MP0010030_abnormal_orbit_morphology0.68597500
97MP0002971_abnormal_brown_adipose0.67815438
98* MP0001544_abnormal_cardiovascular_syste0.67705099
99* MP0005385_cardiovascular_system_phenoty0.67705099
100MP0002019_abnormal_tumor_incidence0.66572584
101MP0003718_maternal_effect0.66197393
102MP0010094_abnormal_chromosome_stability0.66143503
103MP0003693_abnormal_embryo_hatching0.66140276
104* MP0003077_abnormal_cell_cycle0.65669221
105MP0001929_abnormal_gametogenesis0.64386077
106MP0003111_abnormal_nucleus_morphology0.63946459
107* MP0009642_abnormal_blood_homeostasis0.63562101
108* MP0010630_abnormal_cardiac_muscle0.62914033
109MP0003646_muscle_fatigue0.62886267
110MP0006138_congestive_heart_failure0.62473417
111MP0002876_abnormal_thyroid_physiology0.61557315
112MP0002132_abnormal_respiratory_system0.60935953
113* MP0003221_abnormal_cardiomyocyte_apopto0.60688951
114MP0009672_abnormal_birth_weight0.60576806
115* MP0000759_abnormal_skeletal_muscle0.59420188
116MP0008469_abnormal_protein_level0.59353848
117MP0005408_hypopigmentation0.58878523
118MP0004197_abnormal_fetal_growth/weight/0.57302785
119MP0004215_abnormal_myocardial_fiber0.57234903
120MP0005023_abnormal_wound_healing0.57038394
121MP0009115_abnormal_fat_cell0.56760354
122* MP0002078_abnormal_glucose_homeostasis0.56339839
123MP0002136_abnormal_kidney_physiology0.56067022
124MP0000750_abnormal_muscle_regeneration0.54622171
125MP0001661_extended_life_span0.53596972
126MP0000350_abnormal_cell_proliferation0.53323794
127MP0009765_abnormal_xenobiotic_induced0.52980677
128* MP0004087_abnormal_muscle_fiber0.52342628
129* MP0002080_prenatal_lethality0.52008701
130MP0003567_abnormal_fetal_cardiomyocyte0.50567351
131MP0009764_decreased_sensitivity_to0.49755157
132* MP0000358_abnormal_cell_content/0.49260148
133* MP0002127_abnormal_cardiovascular_syste0.48369115
134* MP0001697_abnormal_embryo_size0.47868388
135MP0001243_abnormal_dermal_layer0.47674117
136MP0002396_abnormal_hematopoietic_system0.47495223
137MP0003123_paternal_imprinting0.47189575
138MP0004036_abnormal_muscle_relaxation0.47171672
139MP0008873_increased_physiological_sensi0.47103068

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.54475573
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.30311393
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.11614781
4Hyperglycinuria (HP:0003108)5.06543316
5Deep venous thrombosis (HP:0002625)5.05094059
6Hypobetalipoproteinemia (HP:0003563)4.98485898
7Hyperammonemia (HP:0001987)4.84115972
8Xanthomatosis (HP:0000991)4.68581708
9Abnormality of glycine metabolism (HP:0010895)4.67096934
10Abnormality of serine family amino acid metabolism (HP:0010894)4.67096934
11Hyperglycinemia (HP:0002154)4.46003451
12Hypochromic microcytic anemia (HP:0004840)4.35766610
13Ketosis (HP:0001946)4.12664333
14Prolonged partial thromboplastin time (HP:0003645)4.06304727
15Hypoglycemic coma (HP:0001325)3.97234190
16Abnormality of fatty-acid metabolism (HP:0004359)3.94804075
17Multiple enchondromatosis (HP:0005701)3.90060656
18Hypolipoproteinemia (HP:0010981)3.88712593
19Abnormality of aspartate family amino acid metabolism (HP:0010899)3.69005633
20Hyperlipoproteinemia (HP:0010980)3.66207556
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.65222900
22Abnormality of the intrinsic pathway (HP:0010989)3.62714747
23Abnormality of dicarboxylic acid metabolism (HP:0010995)3.61640217
24Dicarboxylic aciduria (HP:0003215)3.61640217
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.51738757
26Ketoacidosis (HP:0001993)3.51611642
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49941752
28Abnormality of methionine metabolism (HP:0010901)3.46026776
29Chromsome breakage (HP:0040012)3.45768168
30Abnormality of pyrimidine metabolism (HP:0004353)3.43750259
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.42504584
32Hypoalphalipoproteinemia (HP:0003233)3.42181426
33Complement deficiency (HP:0004431)3.33098225
34Microvesicular hepatic steatosis (HP:0001414)3.31825627
35Gout (HP:0001997)3.31760685
36Abnormal cartilage morphology (HP:0002763)3.31755957
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22217056
38Abnormality of serum amino acid levels (HP:0003112)3.21516907
39Abnormal mitochondria in muscle tissue (HP:0008316)3.20786863
40Epidermoid cyst (HP:0200040)3.12588588
41Metabolic acidosis (HP:0001942)3.11698163
42Acute necrotizing encephalopathy (HP:0006965)3.08280016
43Lethargy (HP:0001254)3.08081322
44Hepatocellular necrosis (HP:0001404)2.99426228
45Joint hemorrhage (HP:0005261)2.94127870
46Abnormality of nucleobase metabolism (HP:0010932)2.92402231
47Fat malabsorption (HP:0002630)2.92180739
48Delayed CNS myelination (HP:0002188)2.88522551
49Cerebral edema (HP:0002181)2.85535876
50Abnormality of the common coagulation pathway (HP:0010990)2.81143938
51Proximal tubulopathy (HP:0000114)2.80653805
52Skin nodule (HP:0200036)2.79420383
53Malnutrition (HP:0004395)2.79215487
54Generalized aminoaciduria (HP:0002909)2.78429412
55Hyperinsulinemic hypoglycemia (HP:0000825)2.78144055
56* Increased CSF lactate (HP:0002490)2.77503766
57Hyperbilirubinemia (HP:0002904)2.71898216
58* Increased serum lactate (HP:0002151)2.68622620
59Abnormality of purine metabolism (HP:0004352)2.66728216
60Myoglobinuria (HP:0002913)2.63866002
61Hepatoblastoma (HP:0002884)2.61962656
62Hypercholesterolemia (HP:0003124)2.60288653
63Lactic acidosis (HP:0003128)2.59661473
64Vomiting (HP:0002013)2.59602891
65Abnormality of alanine metabolism (HP:0010916)2.56208333
66Hyperalaninemia (HP:0003348)2.56208333
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56208333
68Nausea (HP:0002018)2.55378498
69Spastic diplegia (HP:0001264)2.51875689
70Mitochondrial inheritance (HP:0001427)2.51700166
71Abnormality of complement system (HP:0005339)2.51151386
72Progressive external ophthalmoplegia (HP:0000590)2.48222266
73Testicular atrophy (HP:0000029)2.47192718
74Exercise intolerance (HP:0003546)2.46168487
75Rhabdomyolysis (HP:0003201)2.46107528
76Hepatocellular carcinoma (HP:0001402)2.44149582
77Ventricular tachycardia (HP:0004756)2.43636399
78Bilateral microphthalmos (HP:0007633)2.41231679
79* Ragged-red muscle fibers (HP:0003200)2.32811673
80Increased purine levels (HP:0004368)2.32475011
81Hyperuricemia (HP:0002149)2.32475011
82Right ventricular cardiomyopathy (HP:0011663)2.32125694
83Reticulocytopenia (HP:0001896)2.31898314
84Increased intramyocellular lipid droplets (HP:0012240)2.28619753
85Progressive macrocephaly (HP:0004481)2.23665993
86Cholelithiasis (HP:0001081)2.21927864
87Irritability (HP:0000737)2.19754942
88Abnormality of the lower motor neuron (HP:0002366)2.18639108
89Lipid accumulation in hepatocytes (HP:0006561)2.17240576
90Steatorrhea (HP:0002570)2.15826198
91Increased hepatocellular lipid droplets (HP:0006565)2.15398765
92Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14990622
93Hepatic necrosis (HP:0002605)2.14804225
94Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12276439
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12276439
96Abnormal gallbladder morphology (HP:0012437)2.10963369
97Type I transferrin isoform profile (HP:0003642)2.10411651
98Increased muscle lipid content (HP:0009058)2.09812963
99Abnormality of reticulocytes (HP:0004312)2.09215940
100Degeneration of anterior horn cells (HP:0002398)2.08019338
101Abnormality of the anterior horn cell (HP:0006802)2.08019338
102Reduced antithrombin III activity (HP:0001976)2.07595863
103Conjugated hyperbilirubinemia (HP:0002908)2.07228168
104Abnormality of the preputium (HP:0100587)2.06635256
105Exercise-induced myalgia (HP:0003738)2.04593274
106Respiratory failure (HP:0002878)2.03306143
107Palpitations (HP:0001962)2.01531462
108Secondary amenorrhea (HP:0000869)1.99991861
109CNS demyelination (HP:0007305)1.98487292
110Abnormality of the gallbladder (HP:0005264)1.98326795
111Premature ovarian failure (HP:0008209)1.97971269
112Renal Fanconi syndrome (HP:0001994)1.97324013
113Enlarged kidneys (HP:0000105)1.96497247
114Birth length less than 3rd percentile (HP:0003561)1.95767940
115Abnormality of urine glucose concentration (HP:0011016)1.95512236
116Glycosuria (HP:0003076)1.95512236
117Abnormal gallbladder physiology (HP:0012438)1.93776394
118Cholecystitis (HP:0001082)1.93776394
119Renal cortical cysts (HP:0000803)1.91998609
120Myocardial infarction (HP:0001658)1.90974848
121Abnormality of iron homeostasis (HP:0011031)1.90619413
122Abnormality of transition element cation homeostasis (HP:0011030)1.90374700
123Sudden death (HP:0001699)1.90273947
124Rhabdomyosarcoma (HP:0002859)1.89214137
125Exercise-induced muscle cramps (HP:0003710)1.89107051
126Hypochromic anemia (HP:0001931)1.83737027
127Neonatal onset (HP:0003623)1.83650772
128Acute encephalopathy (HP:0006846)1.82381686
129Dilated cardiomyopathy (HP:0001644)1.81777738
130Upper motor neuron abnormality (HP:0002127)1.80030485
131Increased nuchal translucency (HP:0010880)1.78284510
132Pancreatic islet-cell hyperplasia (HP:0004510)1.78144144
133Abnormal enzyme/coenzyme activity (HP:0012379)1.77392100
134Septate vagina (HP:0001153)1.77339930
135Aplasia/Hypoplasia of the uvula (HP:0010293)1.77076937
136Ependymoma (HP:0002888)1.75540438
137Abnormality of vitamin metabolism (HP:0100508)1.75500531
138Late onset (HP:0003584)1.74644103
139Increased serum ferritin (HP:0003281)1.73929360
140Reticulocytosis (HP:0001923)1.73346523
141* Abnormality of glycolysis (HP:0004366)1.73137377
142* Increased serum pyruvate (HP:0003542)1.73137377
143Pseudobulbar signs (HP:0002200)1.71723003
144Abnormality of chromosome stability (HP:0003220)1.71373735
145Progressive muscle weakness (HP:0003323)1.71208473
146Vascular calcification (HP:0004934)1.70904976
147Back pain (HP:0003418)1.70206384
148Limb hypertonia (HP:0002509)1.70098800
149Aplasia cutis congenita (HP:0001057)1.68390633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.26375225
2CDK124.61999800
3ERN14.56097088
4VRK23.06726078
5NEK12.65454972
6TTK2.56886278
7PBK2.55683937
8SRPK12.47348631
9GRK62.46175667
10PKN22.38670707
11EEF2K2.26895593
12SMG12.25725426
13SIK12.21351848
14IRAK32.20565326
15PDK32.17269976
16PDK42.17269976
17MST42.09135917
18TRIB31.95349072
19SCYL21.91795841
20STK101.83589217
21TSSK61.78739298
22GRK51.76078144
23STK38L1.75943829
24FLT31.72376921
25CSF1R1.70122430
26NME11.69997767
27TGFBR21.67440316
28WEE11.64941478
29FGFR41.51169010
30ACVR1B1.50336788
31PLK41.50063629
32GRK71.48893177
33EIF2AK11.47676905
34BUB11.44835307
35PLK31.29908077
36CDK71.28762233
37BRSK11.25434762
38MAP2K41.24843204
39CDC71.24743863
40GRK11.24208728
41ATR1.23019035
42MAPK71.22396528
43MAP2K31.21826473
44EPHA21.20001195
45LATS11.19771163
46MAP3K101.17862578
47PDK21.17309030
48ERBB41.16652341
49CDK41.12261044
50PLK11.11263498
51PAK41.09851225
52NEK21.05891183
53CCNB11.05617294
54MATK1.04174511
55TTN1.02194871
56MAPK110.99334180
57OBSCN0.98679501
58MKNK10.95652545
59KDR0.92007014
60TAF10.86422256
61BRSK20.85976566
62MAP2K60.85684471
63LIMK10.82104119
64ADRBK20.80511105
65AURKB0.79161267
66RPS6KB20.78911170
67NEK90.77478145
68STK40.75396355
69PIM20.75237225
70AKT20.74372555
71ABL20.73842291
72MYLK0.73654605
73NME20.72410803
74ALK0.70946546
75EIF2AK30.70063566
76PRKG20.69502159
77ATM0.68994728
78ICK0.68017719
79MTOR0.67584310
80LATS20.67525675
81WNK30.67065910
82MAP3K80.66765532
83CHEK20.66033021
84CDK80.65655011
85AKT30.65574947
86TLK10.65089181
87MAP3K70.64797123
88CSNK2A20.64009325
89CAMK40.63183959
90MOS0.63144858
91STK30.63131904
92DAPK10.62540853
93MAPKAPK30.62533220
94MAPKAPK50.62309942
95VRK10.61448164
96CSNK2A10.61240396
97MST1R0.61203541
98MET0.60498017
99CLK10.59035494
100CAMK1D0.57771556
101BRAF0.56765428
102CHEK10.56509497
103CDK10.55940760
104TESK20.55566739
105TESK10.55083747
106PRKCI0.54899446
107MAP3K110.54836124
108LRRK20.53949922
109DMPK0.53796330
110CSNK1G30.53689306
111MAPK120.52927437
112TYRO30.51447907
113MAP3K30.51211508
114PHKG10.50635934
115PHKG20.50635934
116TRIM280.49825581
117DAPK30.49330034
118AURKA0.49153954
119CSNK1E0.48662198
120PRKAA20.48636699
121TIE10.48287944
122PRKAA10.48128672
123PIK3CG0.47952370
124CAMK1G0.47608965
125CSK0.47117812
126ADRBK10.46992294
127TGFBR10.44801457
128TAOK20.42863798
129PRKACG0.41887587
130LMTK20.41816754
131MAP3K50.41172662
132MAP4K20.40972328
133PTK60.40728472
134ARAF0.40381421
135ERBB20.39672361
136ILK0.39458266
137EIF2AK20.38898291
138PDGFRA0.38811757
139MELK0.38552928
140WNK10.38249579
141STK160.36588996
142PIK3CA0.36461886
143CSNK1A1L0.35641855
144IGF1R0.35380368
145CDK60.34907917
146RIPK10.34149051
147MUSK0.33565181
148PTK20.32294402
149CDK20.32026767
150MAPK40.32023213
151CSNK1G10.31504040

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.28719489
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.01499258
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.99434234
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.85613268
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.79750726
6Fatty acid degradation_Homo sapiens_hsa000712.67973150
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.66857034
8Tryptophan metabolism_Homo sapiens_hsa003802.51027605
9Propanoate metabolism_Homo sapiens_hsa006402.48063929
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45497852
11Arginine biosynthesis_Homo sapiens_hsa002202.39081550
12Nitrogen metabolism_Homo sapiens_hsa009102.37846334
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27175653
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24002951
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.15904164
16Carbon metabolism_Homo sapiens_hsa012001.98698697
17Fatty acid metabolism_Homo sapiens_hsa012121.98148541
18Butanoate metabolism_Homo sapiens_hsa006501.97196904
19Complement and coagulation cascades_Homo sapiens_hsa046101.91302697
20Peroxisome_Homo sapiens_hsa041461.90461353
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85496574
22Pyruvate metabolism_Homo sapiens_hsa006201.84062099
23Vitamin B6 metabolism_Homo sapiens_hsa007501.81582443
24Biosynthesis of amino acids_Homo sapiens_hsa012301.74582481
25PPAR signaling pathway_Homo sapiens_hsa033201.74332781
26Selenocompound metabolism_Homo sapiens_hsa004501.71085389
27Chemical carcinogenesis_Homo sapiens_hsa052041.66330466
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62121253
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60710951
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.59892638
31Non-homologous end-joining_Homo sapiens_hsa034501.59702486
32beta-Alanine metabolism_Homo sapiens_hsa004101.56326950
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.53641017
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52334191
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48029891
36Ribosome_Homo sapiens_hsa030101.47031661
37One carbon pool by folate_Homo sapiens_hsa006701.46022138
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44582966
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.40558948
40Folate biosynthesis_Homo sapiens_hsa007901.34691328
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.30821457
42Histidine metabolism_Homo sapiens_hsa003401.30036012
43Retinol metabolism_Homo sapiens_hsa008301.27549804
44Fatty acid elongation_Homo sapiens_hsa000621.24498157
45Caffeine metabolism_Homo sapiens_hsa002321.23858497
46Phenylalanine metabolism_Homo sapiens_hsa003601.23248499
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.22709545
48Starch and sucrose metabolism_Homo sapiens_hsa005001.21684627
49Tyrosine metabolism_Homo sapiens_hsa003501.16174518
50RNA polymerase_Homo sapiens_hsa030201.13822375
51Fructose and mannose metabolism_Homo sapiens_hsa000511.13291166
52Bile secretion_Homo sapiens_hsa049761.08225688
53Pentose phosphate pathway_Homo sapiens_hsa000301.07151538
54Sulfur metabolism_Homo sapiens_hsa009201.06649999
55Fat digestion and absorption_Homo sapiens_hsa049751.03869967
56Sulfur relay system_Homo sapiens_hsa041221.02281052
57Glutathione metabolism_Homo sapiens_hsa004800.97906676
58Arginine and proline metabolism_Homo sapiens_hsa003300.97277486
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94519331
60Fanconi anemia pathway_Homo sapiens_hsa034600.90454128
61Galactose metabolism_Homo sapiens_hsa000520.89633410
62Staphylococcus aureus infection_Homo sapiens_hsa051500.88680644
63Lysine degradation_Homo sapiens_hsa003100.88444707
64Protein export_Homo sapiens_hsa030600.87878998
65Alzheimers disease_Homo sapiens_hsa050100.77078477
66Vitamin digestion and absorption_Homo sapiens_hsa049770.75687199
67ABC transporters_Homo sapiens_hsa020100.75493597
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73115266
69Purine metabolism_Homo sapiens_hsa002300.72297018
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72214697
71Basal transcription factors_Homo sapiens_hsa030220.72194707
72Cardiac muscle contraction_Homo sapiens_hsa042600.71777330
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71603511
74DNA replication_Homo sapiens_hsa030300.67289596
75Steroid biosynthesis_Homo sapiens_hsa001000.66575820
76Glycerolipid metabolism_Homo sapiens_hsa005610.65420302
77Metabolic pathways_Homo sapiens_hsa011000.63785444
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63556498
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62701377
80mRNA surveillance pathway_Homo sapiens_hsa030150.60955849
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50448107
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48000515
83Proteasome_Homo sapiens_hsa030500.47348644
84N-Glycan biosynthesis_Homo sapiens_hsa005100.46924846
85Mismatch repair_Homo sapiens_hsa034300.45890449
86Fatty acid biosynthesis_Homo sapiens_hsa000610.43428110
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42778278
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41858367
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.40896774
90Linoleic acid metabolism_Homo sapiens_hsa005910.40603084
91Other glycan degradation_Homo sapiens_hsa005110.40418230
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38273287
93RNA transport_Homo sapiens_hsa030130.33616278
94Pyrimidine metabolism_Homo sapiens_hsa002400.33036713
95Arachidonic acid metabolism_Homo sapiens_hsa005900.32984545
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32863066
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28227549
98Parkinsons disease_Homo sapiens_hsa050120.24519879
99Oocyte meiosis_Homo sapiens_hsa041140.20976547
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20322908
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.19182972
102Insulin resistance_Homo sapiens_hsa049310.18923920
103Base excision repair_Homo sapiens_hsa034100.18916629
104Oxidative phosphorylation_Homo sapiens_hsa001900.18176380
105p53 signaling pathway_Homo sapiens_hsa041150.15263469
106AMPK signaling pathway_Homo sapiens_hsa041520.14867084
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.13358212
108Epstein-Barr virus infection_Homo sapiens_hsa051690.13354628
109Homologous recombination_Homo sapiens_hsa034400.10964487
110Nucleotide excision repair_Homo sapiens_hsa034200.10805718
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.09104242
112Cell cycle_Homo sapiens_hsa041100.07443209
113Thyroid cancer_Homo sapiens_hsa052160.04594434
114Huntingtons disease_Homo sapiens_hsa050160.03479229
115Renin-angiotensin system_Homo sapiens_hsa046140.02729789
116Spliceosome_Homo sapiens_hsa030400.01405570
117Glucagon signaling pathway_Homo sapiens_hsa049220.01117378
118RNA degradation_Homo sapiens_hsa03018-0.0149641

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