AIFM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)6.99496617
2low-density lipoprotein particle clearance (GO:0034383)6.78686627
3fatty acid transmembrane transport (GO:1902001)5.83165581
4fatty acid beta-oxidation (GO:0006635)5.53693520
5carnitine shuttle (GO:0006853)5.52483033
6triglyceride catabolic process (GO:0019433)5.44754611
7biotin metabolic process (GO:0006768)5.41222768
8valine metabolic process (GO:0006573)5.36067540
9positive regulation of fatty acid beta-oxidation (GO:0032000)5.29353495
10positive regulation of fatty acid oxidation (GO:0046321)5.28707656
11neutral lipid catabolic process (GO:0046461)5.06758006
12acylglycerol catabolic process (GO:0046464)5.06758006
13alpha-linolenic acid metabolic process (GO:0036109)4.99647920
14fatty acid oxidation (GO:0019395)4.98441084
15regulation of cholesterol storage (GO:0010885)4.97932293
16brown fat cell differentiation (GO:0050873)4.96060856
17lipid oxidation (GO:0034440)4.90035639
18fatty acid catabolic process (GO:0009062)4.85420181
19regulation of fatty acid oxidation (GO:0046320)4.80175870
20regulation of triglyceride catabolic process (GO:0010896)4.61211052
21acetyl-CoA metabolic process (GO:0006084)4.53597823
22plasma lipoprotein particle clearance (GO:0034381)4.51811278
23carnitine transmembrane transport (GO:1902603)4.46413646
24branched-chain amino acid catabolic process (GO:0009083)4.33205772
25regulation of fatty acid beta-oxidation (GO:0031998)4.30676512
26positive regulation of lipid catabolic process (GO:0050996)4.29155415
27complement activation, alternative pathway (GO:0006957)4.25807807
28white fat cell differentiation (GO:0050872)4.25444501
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.25278344
30branched-chain amino acid metabolic process (GO:0009081)4.20581960
31amino-acid betaine transport (GO:0015838)4.20386707
32carnitine transport (GO:0015879)4.20386707
33monocarboxylic acid catabolic process (GO:0072329)4.13003237
34tricarboxylic acid cycle (GO:0006099)4.11571868
35sulfur amino acid catabolic process (GO:0000098)4.05350447
36negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.04389588
37positive regulation of lipid storage (GO:0010884)4.03038175
38lysine metabolic process (GO:0006553)4.02385835
39lysine catabolic process (GO:0006554)4.02385835
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.01391536
41carnitine metabolic process (GO:0009437)3.89642874
422-oxoglutarate metabolic process (GO:0006103)3.88859094
43triglyceride biosynthetic process (GO:0019432)3.87942145
44short-chain fatty acid metabolic process (GO:0046459)3.86708360
45lipid particle organization (GO:0034389)3.86314554
46tricarboxylic acid metabolic process (GO:0072350)3.86179539
47NADH metabolic process (GO:0006734)3.84883071
48thioester biosynthetic process (GO:0035384)3.84357994
49acyl-CoA biosynthetic process (GO:0071616)3.84357994
50triglyceride homeostasis (GO:0070328)3.84221421
51acylglycerol homeostasis (GO:0055090)3.84221421
52positive regulation of fatty acid metabolic process (GO:0045923)3.84109652
53positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.82263492
54erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.78875456
55L-phenylalanine catabolic process (GO:0006559)3.78875456
56neutral lipid biosynthetic process (GO:0046460)3.78338091
57acylglycerol biosynthetic process (GO:0046463)3.78338091
58amino-acid betaine metabolic process (GO:0006577)3.76859177
59positive regulation of lipoprotein lipase activity (GO:0051006)3.71292003
60positive regulation of triglyceride lipase activity (GO:0061365)3.71292003
61L-phenylalanine metabolic process (GO:0006558)3.66305770
62erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.66305770
63positive regulation of triglyceride metabolic process (GO:0090208)3.65618149
64triglyceride metabolic process (GO:0006641)3.64657111
65lipid storage (GO:0019915)3.63811467
66glycerolipid catabolic process (GO:0046503)3.63337804
67intracellular lipid transport (GO:0032365)3.60795402
68barbed-end actin filament capping (GO:0051016)3.58967759
69fatty-acyl-CoA biosynthetic process (GO:0046949)3.58910446
70succinate metabolic process (GO:0006105)3.54084596
71regulation of triglyceride metabolic process (GO:0090207)3.53742119
72fatty-acyl-CoA metabolic process (GO:0035337)3.48228860
73regulation of membrane protein ectodomain proteolysis (GO:0051043)3.46950082
74polyketide metabolic process (GO:0030638)3.46533957
75doxorubicin metabolic process (GO:0044598)3.46533957
76daunorubicin metabolic process (GO:0044597)3.46533957
77negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.45368330
78acylglycerol metabolic process (GO:0006639)3.44447908
79fatty acid homeostasis (GO:0055089)3.40784881
80neutral lipid metabolic process (GO:0006638)3.38759396
81quaternary ammonium group transport (GO:0015697)3.38392522
82regulation of triglyceride biosynthetic process (GO:0010866)3.38051436
83epoxygenase P450 pathway (GO:0019373)3.36222942
84glycosphingolipid catabolic process (GO:0046479)3.31691008
85urea metabolic process (GO:0019627)3.31130157
86urea cycle (GO:0000050)3.31130157
87cellular ketone body metabolic process (GO:0046950)3.28017247
88adhesion of symbiont to host (GO:0044406)3.27829369
89negative regulation of lipase activity (GO:0060192)3.27778408
90regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.27474279
91oxaloacetate metabolic process (GO:0006107)3.27020434
92negative regulation of lipid storage (GO:0010888)3.23447784
93acyl-CoA metabolic process (GO:0006637)3.23301635
94thioester metabolic process (GO:0035383)3.23301635
95regulation of lipid catabolic process (GO:0050994)3.18824951
96regulation of cholesterol metabolic process (GO:0090181)3.18750064
97regulation of lipid storage (GO:0010883)3.17276031
98coenzyme A biosynthetic process (GO:0015937)3.16797769
99carboxylic acid catabolic process (GO:0046395)3.16107645
100organic acid catabolic process (GO:0016054)3.16107645
101phospholipid homeostasis (GO:0055091)3.15625758
102ethanol oxidation (GO:0006069)3.15411828
103apoptotic cell clearance (GO:0043277)3.15075701
104negative regulation of fatty acid biosynthetic process (GO:0045717)3.14317923
105cysteine metabolic process (GO:0006534)3.13731268
106nitrogen cycle metabolic process (GO:0071941)3.12800760
107long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.11923368
108transcytosis (GO:0045056)3.11559649
109regulation of macrophage derived foam cell differentiation (GO:0010743)3.09539022
110regulation of protein activation cascade (GO:2000257)3.09137764
111glyoxylate metabolic process (GO:0046487)3.06139995
112cellular lipid catabolic process (GO:0044242)3.06117730
113regulation of complement activation (GO:0030449)3.05171673
114oligosaccharide catabolic process (GO:0009313)3.04165093
115adhesion of symbiont to host cell (GO:0044650)3.03490174
116virion attachment to host cell (GO:0019062)3.03490174
117glycolipid catabolic process (GO:0019377)2.99165178
118positive regulation of endothelial cell apoptotic process (GO:2000353)2.96105619
119regulation of vitamin metabolic process (GO:0030656)2.94959678
120regulation of mononuclear cell migration (GO:0071675)2.94694935
121aminoglycoside antibiotic metabolic process (GO:0030647)2.94661000
122serine transport (GO:0032329)2.91254052
123positive regulation of extracellular matrix organization (GO:1903055)2.91115925
124regulation of vitamin D biosynthetic process (GO:0060556)2.88491395
125diacylglycerol metabolic process (GO:0046339)2.83762264
126negative regulation of nitric oxide biosynthetic process (GO:0045019)2.81417560
127cellular response to arsenic-containing substance (GO:0071243)2.81267223
128positive regulation of cholesterol efflux (GO:0010875)2.78227091
129regulation of cholesterol homeostasis (GO:2000188)2.75840767
130keratan sulfate catabolic process (GO:0042340)2.70661563
131negative regulation of macrophage differentiation (GO:0045650)2.68474849
132protein localization to endosome (GO:0036010)2.67386554
133endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.65811056
134cellular response to cadmium ion (GO:0071276)2.64558919
135NIK/NF-kappaB signaling (GO:0038061)2.63920703
136regulation of cytokine secretion involved in immune response (GO:0002739)2.61929662
137glycoside metabolic process (GO:0016137)2.57752888
138negative regulation of granulocyte differentiation (GO:0030853)2.57418010
139response to thyroid hormone (GO:0097066)2.55467732
140skin morphogenesis (GO:0043589)2.54671668
141peptidyl-glutamic acid carboxylation (GO:0017187)2.52908089
142protein carboxylation (GO:0018214)2.52908089
143ovulation from ovarian follicle (GO:0001542)2.52631395
144regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.52059620
145pentose-phosphate shunt (GO:0006098)2.51704836
146ceramide catabolic process (GO:0046514)2.51249814
147positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.50935013
148regulation of gonadotropin secretion (GO:0032276)2.50781371
149negative regulation of myeloid cell apoptotic process (GO:0033033)2.49356081
150regulation of superoxide anion generation (GO:0032928)2.48771587
151very-low-density lipoprotein particle assembly (GO:0034379)2.47718016
152diaphragm development (GO:0060539)2.46422423
153COPI coating of Golgi vesicle (GO:0048205)2.44267965
154Golgi transport vesicle coating (GO:0048200)2.44267965
155regulation of heterotypic cell-cell adhesion (GO:0034114)2.43309995
156regulation of macrophage chemotaxis (GO:0010758)2.42939687
157glucose 6-phosphate metabolic process (GO:0051156)2.42098411
158cellular response to zinc ion (GO:0071294)2.39945700
159positive regulation of Cdc42 GTPase activity (GO:0043089)2.39321755
160protein heterotrimerization (GO:0070208)2.38746105
161pinocytosis (GO:0006907)2.36086291
162stress fiber assembly (GO:0043149)2.35288250
163myeloid dendritic cell differentiation (GO:0043011)2.34282298
164lipopolysaccharide-mediated signaling pathway (GO:0031663)2.34221128
165hyaluronan catabolic process (GO:0030214)2.33353966
166regulation of superoxide metabolic process (GO:0090322)2.33280173
167membrane lipid catabolic process (GO:0046466)2.33209633
168positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.32962942
169negative regulation of metanephros development (GO:0072217)2.32108259
170primary alcohol catabolic process (GO:0034310)2.32013986

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.19484775
2* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse5.41378724
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.38241943
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.74468474
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.43919571
6CLOCK_20551151_ChIP-Seq_293T_Human3.83155604
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.55739838
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.08902681
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.86286166
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.71161741
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60186008
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50758974
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.31531019
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse11.8688859
15TP63_17297297_ChIP-ChIP_HaCaT_Human1.86907575
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76731457
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.76696969
18HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.73253664
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.72134013
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.63305461
21CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.62567046
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57456951
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53342071
24ZNF263_19887448_ChIP-Seq_K562_Human1.53210051
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.50854016
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47345061
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45917042
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45379033
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44609603
30PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.43592932
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43407104
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43338947
33PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.38711137
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36172890
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32848782
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32692221
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32632766
38VDR_21846776_ChIP-Seq_THP-1_Human1.32035158
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31594344
40GATA1_22025678_ChIP-Seq_K562_Human1.29752862
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28398837
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26879072
43* TET1_21451524_ChIP-Seq_MESCs_Mouse1.24509968
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.21396782
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20906565
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18937522
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.18851868
48* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17505418
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17451493
50TFEB_21752829_ChIP-Seq_HELA_Human1.15735869
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13821866
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12269219
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11517141
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11517141
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10968361
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.10303008
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.10303008
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.10224286
59TP53_22127205_ChIP-Seq_IMR90_Human1.09123785
60TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08265919
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.06955136
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06945796
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06505315
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06134010
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.04410447
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04302706
67JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03636242
68P68_20966046_ChIP-Seq_HELA_Human1.03014674
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.01872256
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01526719
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01314322
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00351212
73CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99503858
74ESR2_21235772_ChIP-Seq_MCF-7_Human0.99115394
75KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98312975
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97527103
77MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97222942
78IRF8_27001747_Chip-Seq_BMDM_Mouse0.96598562
79TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96487228
80SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96353028
81STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96125541
82CTCF_26484167_Chip-Seq_Bcells_Mouse0.95468650
83ELF1_20517297_ChIP-Seq_JURKAT_Human0.94735136
84LXR_22292898_ChIP-Seq_THP-1_Human0.94662747
85KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94471348
86* BCL6_27268052_Chip-Seq_Bcells_Human0.92195551
87SMC4_20622854_ChIP-Seq_HELA_Human0.92167504
88SA1_27219007_Chip-Seq_ERYTHROID_Human0.91806232
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91323077
90CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90907618
91E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89277108
92* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88392819
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87562559
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87562559
95CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86850801
96* HNF4A_19822575_ChIP-Seq_HepG2_Human0.86766706
97ESR1_20079471_ChIP-ChIP_T-47D_Human0.85841898
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.84407651
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83062052
100EP300_21415370_ChIP-Seq_HL-1_Mouse0.82357217
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82345047
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82079690
103GATA1_19941826_ChIP-Seq_K562_Human0.81537610
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81267382
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81224668
106NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80570068
107GATA4_25053715_ChIP-Seq_YYC3_Human0.78701581
108RACK7_27058665_Chip-Seq_MCF-7_Human0.78582052
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.77206405
110P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75222663
111* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73303190
112SOX2_20726797_ChIP-Seq_SW620_Human0.71231705
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.70875151
114CJUN_26792858_Chip-Seq_BT549_Human0.70381283
115SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70215774
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.70115108
117GATA2_19941826_ChIP-Seq_K562_Human0.69566275
118* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.68832425
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.68125645
120VDR_24787735_ChIP-Seq_THP-1_Human0.68078204
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.66054820
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.65633628
123* ATF3_27146783_Chip-Seq_COLON_Human0.65080718
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.65032828
125GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.64057171
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63456770
127* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.63289489
128SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.62345168
129TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.61706777
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.60849045
131GATA3_24758297_ChIP-Seq_MCF-7_Human0.59826711
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.59762513
133RXRA_24833708_ChIP-Seq_LIVER_Mouse0.58799503
134CSB_26484114_Chip-Seq_FIBROBLAST_Human0.58382743
135FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.57906722
136NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.56828620
137CEBPB_22108803_ChIP-Seq_LS180_Human0.56137380
138BCOR_27268052_Chip-Seq_Bcells_Human0.54875159
139ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.54544104
140SOX9_24532713_ChIP-Seq_HFSC_Mouse0.54119692
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.53848875
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53537203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.13797975
2MP0005666_abnormal_adipose_tissue4.14342109
3MP0002139_abnormal_hepatobiliary_system4.03129456
4MP0004130_abnormal_muscle_cell3.98748200
5MP0005360_urolithiasis3.50509421
6MP0010329_abnormal_lipoprotein_level3.45018011
7MP0005365_abnormal_bile_salt3.34113802
8MP0004185_abnormal_adipocyte_glucose3.32663860
9MP0008438_abnormal_cutaneous_collagen3.01335978
10MP0005375_adipose_tissue_phenotype2.92124544
11MP0003191_abnormal_cellular_cholesterol2.87310830
12MP0002971_abnormal_brown_adipose2.86481650
13MP0002837_dystrophic_cardiac_calcinosis2.85480209
14MP0005085_abnormal_gallbladder_physiolo2.67901052
15MP0008875_abnormal_xenobiotic_pharmacok2.55316669
16MP0002118_abnormal_lipid_homeostasis2.39029861
17MP0003950_abnormal_plasma_membrane2.27140810
18MP0003705_abnormal_hypodermis_morpholog2.18361427
19MP0002877_abnormal_melanocyte_morpholog2.12083438
20MP0005451_abnormal_body_composition2.04657183
21MP0009115_abnormal_fat_cell2.03617296
22MP0000013_abnormal_adipose_tissue2.03572917
23MP0000609_abnormal_liver_physiology1.92259447
24MP0005332_abnormal_amino_acid1.90211948
25MP0000003_abnormal_adipose_tissue1.90074448
26MP0005334_abnormal_fat_pad1.89656949
27MP0003303_peritoneal_inflammation1.87862882
28MP0005257_abnormal_intraocular_pressure1.86623251
29MP0002148_abnormal_hypersensitivity_rea1.83129814
30MP0009840_abnormal_foam_cell1.81144949
31MP0000858_altered_metastatic_potential1.76822091
32MP0005535_abnormal_body_temperature1.75336946
33MP0003186_abnormal_redox_activity1.73736022
34MP0005275_abnormal_skin_tensile1.73524124
35MP0009785_altered_susceptibility_to1.68851750
36MP0002970_abnormal_white_adipose1.68298005
37MP0003075_altered_response_to1.62011930
38MP0003436_decreased_susceptibility_to1.61983692
39MP0002876_abnormal_thyroid_physiology1.57969221
40MP0005319_abnormal_enzyme/_coenzyme1.56408095
41MP0003806_abnormal_nucleotide_metabolis1.54420775
42MP0004510_myositis1.54350669
43MP0003252_abnormal_bile_duct1.52736377
44MP0003646_muscle_fatigue1.52299504
45MP0005584_abnormal_enzyme/coenzyme_acti1.52279499
46MP0006036_abnormal_mitochondrial_physio1.52163981
47MP0003453_abnormal_keratinocyte_physiol1.50849480
48MP0003724_increased_susceptibility_to1.45671240
49MP0001661_extended_life_span1.43955333
50MP0000685_abnormal_immune_system1.33249440
51MP0003172_abnormal_lysosome_physiology1.32207787
52MP0006082_CNS_inflammation1.30930881
53MP0002078_abnormal_glucose_homeostasis1.30736407
54MP0005448_abnormal_energy_balance1.29817066
55MP0009333_abnormal_splenocyte_physiolog1.28650938
56MP0005023_abnormal_wound_healing1.27061370
57MP0009643_abnormal_urine_homeostasis1.25902557
58MP0005165_increased_susceptibility_to1.25435584
59MP0003959_abnormal_lean_body1.25307245
60MP0003690_abnormal_glial_cell1.22198128
61MP0002909_abnormal_adrenal_gland1.20459998
62MP0004272_abnormal_basement_membrane1.20132260
63MP0000343_altered_response_to1.17275499
64MP0003091_abnormal_cell_migration1.16295271
65MP0005167_abnormal_blood-brain_barrier1.15772255
66MP0003448_altered_tumor_morphology1.15294811
67MP0006054_spinal_hemorrhage1.15087572
68MP0004019_abnormal_vitamin_homeostasis1.14898530
69MP0009764_decreased_sensitivity_to1.14377904
70MP0008775_abnormal_heart_ventricle1.13397036
71MP0005330_cardiomyopathy1.12592925
72MP0001790_abnormal_immune_system1.12574798
73MP0005387_immune_system_phenotype1.12574798
74MP0001666_abnormal_nutrient_absorption1.11630954
75MP0006138_congestive_heart_failure1.11216424
76MP0002419_abnormal_innate_immunity1.10598990
77MP0003195_calcinosis1.09976602
78MP0000751_myopathy1.09634306
79MP0003300_gastrointestinal_ulcer1.09596853
80MP0001764_abnormal_homeostasis1.08505890
81MP0001756_abnormal_urination1.06485383
82MP0005076_abnormal_cell_differentiation1.04890322
83MP0005058_abnormal_lysosome_morphology1.03049807
84MP0005000_abnormal_immune_tolerance1.02426368
85MP0003868_abnormal_feces_composition1.01765577
86MP0002998_abnormal_bone_remodeling1.01578712
87MP0005083_abnormal_biliary_tract1.01400639
88MP0000750_abnormal_muscle_regeneration1.01224263
89MP0004087_abnormal_muscle_fiber1.00676601
90MP0005025_abnormal_response_to0.99988214
91MP0001542_abnormal_bone_strength0.98155926
92MP0005385_cardiovascular_system_phenoty0.97402051
93MP0001544_abnormal_cardiovascular_syste0.97402051
94MP0005452_abnormal_adipose_tissue0.95349086
95MP0001845_abnormal_inflammatory_respons0.95146465
96MP0002254_reproductive_system_inflammat0.95051394
97MP0004233_abnormal_muscle_weight0.94512868
98MP0002332_abnormal_exercise_endurance0.89479010
99MP0000767_abnormal_smooth_muscle0.88230211
100MP0005595_abnormal_vascular_smooth0.87012984
101MP0004947_skin_inflammation0.86598790
102MP0009763_increased_sensitivity_to0.86419252
103MP0001727_abnormal_embryo_implantation0.84975131
104MP0002933_joint_inflammation0.84839998
105MP0003011_delayed_dark_adaptation0.84486102
106MP0000598_abnormal_liver_morphology0.83801949
107MP0003221_abnormal_cardiomyocyte_apopto0.82471134
108MP0000230_abnormal_systemic_arterial0.81947710
109MP0005671_abnormal_response_to0.81211254
110MP0000604_amyloidosis0.80536099
111MP0003329_amyloid_beta_deposits0.80490093
112MP0005620_abnormal_muscle_contractility0.79832796
113MP0003566_abnormal_cell_adhesion0.79582031
114MP0005164_abnormal_response_to0.78933988
115MP0004858_abnormal_nervous_system0.78366082
116MP0002452_abnormal_antigen_presenting0.76581187
117MP0002060_abnormal_skin_morphology0.74575381
118MP0003953_abnormal_hormone_level0.73772771
119MP0001881_abnormal_mammary_gland0.73629430
120MP0004036_abnormal_muscle_relaxation0.72857238
121MP0010630_abnormal_cardiac_muscle0.71912950
122MP0002972_abnormal_cardiac_muscle0.71708948
123MP0004215_abnormal_myocardial_fiber0.71433565
124MP0002822_catalepsy0.70905429
125MP0000249_abnormal_blood_vessel0.70414088
126MP0004084_abnormal_cardiac_muscle0.70208936
127MP0001879_abnormal_lymphatic_vessel0.69250970
128MP0003828_pulmonary_edema0.69016016
129MP0009642_abnormal_blood_homeostasis0.68858676
130MP0008961_abnormal_basal_metabolism0.67433400
131MP0003279_aneurysm0.66276637
132MP0008469_abnormal_protein_level0.65917216
133MP0001853_heart_inflammation0.64350021
134MP0000759_abnormal_skeletal_muscle0.63711753
135MP0005376_homeostasis/metabolism_phenot0.62477166
136MP0010368_abnormal_lymphatic_system0.61326089
137MP0002168_other_aberrant_phenotype0.61188622
138MP0002295_abnormal_pulmonary_circulatio0.60106306
139MP0001533_abnormal_skeleton_physiology0.60094804
140MP0000749_muscle_degeneration0.59296746
141MP0002269_muscular_atrophy0.59024958
142MP0005647_abnormal_sex_gland0.58342440
143MP0005266_abnormal_metabolism0.57721119

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.89315594
2Abnormality of liposaccharide metabolism (HP:0010968)5.89315594
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.89315594
4Hyperglycinuria (HP:0003108)5.60817986
5Hypoglycemic coma (HP:0001325)4.98603578
6Abnormality of fatty-acid metabolism (HP:0004359)4.78511882
7Abnormality of glycine metabolism (HP:0010895)4.74274056
8Abnormality of serine family amino acid metabolism (HP:0010894)4.74274056
9Vertebral compression fractures (HP:0002953)4.68365903
10Oligomenorrhea (HP:0000876)4.63536840
11Myoglobinuria (HP:0002913)4.35636117
12Complement deficiency (HP:0004431)4.29686702
13Hyperammonemia (HP:0001987)4.22631690
14Xanthomatosis (HP:0000991)4.19018243
15Ketosis (HP:0001946)4.17740740
16Dicarboxylic aciduria (HP:0003215)4.10103150
17Abnormality of dicarboxylic acid metabolism (HP:0010995)4.10103150
18Hypertriglyceridemia (HP:0002155)4.06340303
19Hypoalphalipoproteinemia (HP:0003233)3.96237544
20Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.92599941
21Acanthosis nigricans (HP:0000956)3.89914981
22Vacuolated lymphocytes (HP:0001922)3.89619215
23Hyperlipoproteinemia (HP:0010980)3.88028030
24Dysostosis multiplex (HP:0000943)3.82823242
25Rhabdomyolysis (HP:0003201)3.82765590
26Ketoacidosis (HP:0001993)3.78799322
27Hyperglycinemia (HP:0002154)3.61096324
28Deep venous thrombosis (HP:0002625)3.50879686
29Increased muscle lipid content (HP:0009058)3.40399425
30Abnormality of mucopolysaccharide metabolism (HP:0011020)3.37581705
31Abnormality of polysaccharide metabolism (HP:0011012)3.37581705
32Abnormality of glycosaminoglycan metabolism (HP:0004371)3.37581705
33Epidermoid cyst (HP:0200040)3.37127452
34Hydroxyprolinuria (HP:0003080)3.35286334
35Abnormality of proline metabolism (HP:0010907)3.35286334
36Nuclear cataract (HP:0100018)3.32857340
37Abnormality of complement system (HP:0005339)3.27088645
38Axonal loss (HP:0003447)3.26836191
39Mucopolysacchariduria (HP:0008155)3.23446582
40Urinary glycosaminoglycan excretion (HP:0003541)3.23446582
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.20772771
42Premature rupture of membranes (HP:0001788)3.16286011
43Protrusio acetabuli (HP:0003179)3.11761047
44Abnormality of glutamine family amino acid metabolism (HP:0010902)3.10255168
45Hypolipoproteinemia (HP:0010981)3.05073002
46Generalized aminoaciduria (HP:0002909)3.01753011
47Nausea (HP:0002018)2.98805188
48Abnormality of aromatic amino acid family metabolism (HP:0004338)2.98336191
49Myocardial infarction (HP:0001658)2.95828912
50Hepatic necrosis (HP:0002605)2.86565124
51Systemic lupus erythematosus (HP:0002725)2.78472189
52Difficulty running (HP:0009046)2.77858459
53Glomerulonephritis (HP:0000099)2.76651771
54Hypercholesterolemia (HP:0003124)2.76374846
55Increased cerebral lipofuscin (HP:0011813)2.75844738
56Increased connective tissue (HP:0009025)2.74446524
57Loss of speech (HP:0002371)2.73826657
58Intrahepatic cholestasis (HP:0001406)2.72830908
59Skin nodule (HP:0200036)2.71376916
60Insulin-resistant diabetes mellitus (HP:0000831)2.64300170
61Prolonged neonatal jaundice (HP:0006579)2.63229678
62Cervical subluxation (HP:0003308)2.62798555
63Cerebral edema (HP:0002181)2.62214733
64Lethargy (HP:0001254)2.60923945
65Abnormal cartilage morphology (HP:0002763)2.57017535
66Bone cyst (HP:0012062)2.54137766
67Abnormality of monocarboxylic acid metabolism (HP:0010996)2.50872858
68Hemorrhage of the eye (HP:0011885)2.50789740
69Insulin resistance (HP:0000855)2.47522904
70Abnormality of serum amino acid levels (HP:0003112)2.44060217
71Vomiting (HP:0002013)2.43203843
72Metabolic acidosis (HP:0001942)2.40235973
73Mesangial abnormality (HP:0001966)2.38220762
74Prolonged partial thromboplastin time (HP:0003645)2.37280866
75Pancreatitis (HP:0001733)2.36866869
76Long foot (HP:0001833)2.29494057
77Mitral stenosis (HP:0001718)2.28730186
78Abnormality of purine metabolism (HP:0004352)2.28566945
79Conjunctival hamartoma (HP:0100780)2.27702155
80Achilles tendon contracture (HP:0001771)2.27441063
81Abnormality of the Achilles tendon (HP:0005109)2.25294530
82Exercise-induced myalgia (HP:0003738)2.24401800
83Pigmentary retinal degeneration (HP:0001146)2.22902015
84Multiple enchondromatosis (HP:0005701)2.19276360
85Proximal tubulopathy (HP:0000114)2.18249685
86Increased neuronal autofluorescent lipopigment (HP:0002074)2.17361301
87Cholecystitis (HP:0001082)2.15377576
88Abnormal gallbladder physiology (HP:0012438)2.15377576
89Hypobetalipoproteinemia (HP:0003563)2.14994592
90Muscle stiffness (HP:0003552)2.14614177
91Purpura (HP:0000979)2.14540357
92Abnormality of the common coagulation pathway (HP:0010990)2.13262880
93Joint hemorrhage (HP:0005261)2.12221686
94Vascular calcification (HP:0004934)2.11610236
95Right ventricular cardiomyopathy (HP:0011663)2.11299342
96Tetraparesis (HP:0002273)2.11153430
97Facial diplegia (HP:0001349)2.11027034
98Hypoglycemic seizures (HP:0002173)2.10473133
99Progressive neurologic deterioration (HP:0002344)2.10297804
100Renal cortical cysts (HP:0000803)2.10191129
101Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08154536
102Short nail (HP:0001799)2.08151333
103Hyperglycemia (HP:0003074)2.07269719
104Ovoid vertebral bodies (HP:0003300)2.06991008
105Hypokinesia (HP:0002375)2.06558873
106Palpitations (HP:0001962)2.05194696
107Nonimmune hydrops fetalis (HP:0001790)2.04651065
108Methylmalonic aciduria (HP:0012120)2.04484215
109Ragged-red muscle fibers (HP:0003200)2.04298943
110Mutism (HP:0002300)2.03968975
111Gastrointestinal stroma tumor (HP:0100723)2.03283326
112Cardiovascular calcification (HP:0011915)2.02624719
113Growth hormone excess (HP:0000845)2.02052953
114Acute encephalopathy (HP:0006846)1.99010332
115Increased serum pyruvate (HP:0003542)1.98995438
116Abnormality of glycolysis (HP:0004366)1.98995438
117Lipoatrophy (HP:0100578)1.97846038
118Opisthotonus (HP:0002179)1.97483467
119Neurofibrillary tangles (HP:0002185)1.95185321
120Abnormality of macrophages (HP:0004311)1.94315158
121Prenatal maternal abnormality (HP:0002686)1.93146535
122Ileus (HP:0002595)1.92640011
123Beaking of vertebral bodies (HP:0004568)1.91989008
124Osteolytic defects of the hand bones (HP:0009699)1.91148376
125Osteolytic defects of the phalanges of the hand (HP:0009771)1.91148376
126Hyporeflexia of lower limbs (HP:0002600)1.90394261
127Nephritis (HP:0000123)1.89283165
128Broad metatarsal (HP:0001783)1.88644677
129Abnormality of carpal bone ossification (HP:0006257)1.87030505
130Hepatosplenomegaly (HP:0001433)1.86049954
131Upper motor neuron abnormality (HP:0002127)1.86002898
132Cardiomegaly (HP:0001640)1.84828277
133Muscle fiber splitting (HP:0003555)1.84681684
134Multiple lipomas (HP:0001012)1.84646243
135Hypertensive crisis (HP:0100735)1.84143165
136Bone pain (HP:0002653)1.84105345
137Abnormality of sulfur amino acid metabolism (HP:0004339)1.83442977
138Type 1 muscle fiber predominance (HP:0003803)1.83132750
139Tachypnea (HP:0002789)1.82972812
140Amyloidosis (HP:0011034)1.82394552
141Distal lower limb amyotrophy (HP:0008944)1.82014652
142Sensorimotor neuropathy (HP:0007141)1.81698719
143Neonatal onset (HP:0003623)1.80972652
144Spinal rigidity (HP:0003306)1.80771133
145Cerebral inclusion bodies (HP:0100314)1.80557776
146Esophageal varix (HP:0002040)1.79767368
147Esophageal neoplasm (HP:0100751)1.79446364
148Neoplasm of head and neck (HP:0012288)1.79446364
149Increased serum ferritin (HP:0003281)1.79279555
150Lactic acidosis (HP:0003128)1.77350865
151Abnormality of nucleobase metabolism (HP:0010932)1.76308792
152Rough bone trabeculation (HP:0100670)1.75693613
153Cerebral hemorrhage (HP:0001342)1.73523926
154Pathologic fracture (HP:0002756)1.73072905
155Hepatocellular necrosis (HP:0001404)1.72713234
156Asymmetric septal hypertrophy (HP:0001670)1.71723634
157Hyperinsulinemic hypoglycemia (HP:0000825)1.71671135
158Cerebral aneurysm (HP:0004944)1.71297557
159Retinal atrophy (HP:0001105)1.71201778
160Reduced subcutaneous adipose tissue (HP:0003758)1.71195472
161Apathy (HP:0000741)1.71128218
162Abnormal trabecular bone morphology (HP:0100671)1.70697699
163Distal lower limb muscle weakness (HP:0009053)1.70224443
164Elbow flexion contracture (HP:0002987)1.69917520
165Ankle contracture (HP:0006466)1.69262541
166J-shaped sella turcica (HP:0002680)1.68916737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.35453537
2BCKDK5.26257068
3CAMK1D4.38705609
4MST1R3.52788534
5SIK13.37850994
6CAMK1G3.37292129
7PDK43.19782876
8PDK33.19782876
9ERN12.86703020
10EPHA22.69926032
11TESK12.53044034
12PKN22.36255376
13PDK22.27302004
14RIPK12.27193516
15TTN2.21490888
16PAK42.12558977
17PIM22.08820316
18TAOK22.01508206
19PIK3CA1.93849292
20MYLK1.74583501
21FGFR41.72171974
22LMTK21.71589599
23MAP3K141.64812974
24INSRR1.64189824
25PRKAA21.57249911
26MET1.47331663
27ARAF1.42616522
28CDC42BPA1.35099986
29GRK71.29464906
30PRPF4B1.29276120
31MAPKAPK31.27893413
32EPHB21.25562411
33NEK91.20982256
34TGFBR21.20138169
35SMG11.19017974
36TIE11.18435250
37IKBKB1.12574915
38CDK91.12120363
39LIMK11.10022585
40MAP2K11.05485258
41PDGFRA1.05036498
42MOS1.00697541
43PTK60.96384496
44FLT30.93558218
45FGFR30.93225207
46TESK20.92822465
47MAP2K30.92635274
48PDPK10.91647361
49ACVR1B0.90893828
50NEK10.90857957
51JAK10.88396691
52EPHB10.86900477
53CDK60.86494699
54PHKG20.85309799
55PHKG10.85309799
56PIK3CG0.84795520
57TBK10.82474838
58PBK0.80708664
59CLK10.80693920
60CHUK0.79859149
61MATK0.79520844
62ABL20.79096273
63BUB10.77800253
64FGFR20.76396601
65TYK20.75177008
66PRKAA10.74858444
67MAP3K10.74458244
68FRK0.73606165
69TAOK10.73215878
70GSK3A0.72012911
71MAP3K30.70617284
72JAK20.69965375
73IRAK40.69946744
74MAP2K40.66655499
75PRKACG0.64546510
76ICK0.64401440
77MAPK110.63587006
78KDR0.62916734
79PDK10.62667217
80OBSCN0.62614169
81SIK30.62562633
82MTOR0.61298953
83IRAK30.61152386
84ILK0.59066837
85LRRK20.58861808
86MAP3K80.58798205
87CSK0.57771122
88PTK2B0.56799428
89STK100.56420104
90PRKD10.55835894
91MAPK120.55810321
92BMX0.55555034
93STK160.55473109
94MAP3K120.55098110
95PAK20.52949391
96PRKCH0.52839492
97IGF1R0.52765613
98PRKG20.52638189
99DDR20.51260233
100TLK10.50905536
101EIF2AK10.50850484
102MAPK40.49472932
103TAOK30.49251749
104RET0.48186285
105IRAK20.48135597
106NME10.46434623
107MAP2K60.45916095
108DAPK30.45088814
109LATS10.44826916
110MUSK0.44775144
111PAK10.43665254
112PINK10.43479937
113EEF2K0.43321753
114DAPK20.43314382
115MAP3K110.43076673
116PRKCI0.42620083
117BLK0.42028495
118MAP2K20.40482524
119IKBKE0.39587598
120FER0.38185146
121MAP3K60.36878244
122ERBB40.36453542
123MAPKAPK20.36321388
124AKT20.36155513
125ADRBK20.33788333
126PDGFRB0.33538333
127MAP3K130.33131589
128BRAF0.32995959
129JAK30.32760369
130PAK30.32298486
131CDK80.31266500
132TRPM70.30044710
133FGFR10.29710346
134INSR0.28824504
135PTK20.27080639
136SRC0.26043677
137CAMK10.25703038
138CDK40.24727041
139DMPK0.23596526
140KIT0.23156519
141CAMK2G0.23140303
142NME20.22434246
143RPS6KL10.22175985
144RPS6KC10.22175985
145LATS20.21662290
146PRKCZ0.21626463
147PRKD30.21327055
148ABL10.21120362
149KSR20.20200354

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.99129679
2Other glycan degradation_Homo sapiens_hsa005113.95968902
3Fatty acid degradation_Homo sapiens_hsa000713.61009049
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.55375145
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.54230457
6PPAR signaling pathway_Homo sapiens_hsa033203.44156013
7Fatty acid metabolism_Homo sapiens_hsa012123.30210131
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.90551416
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61680917
10Fatty acid biosynthesis_Homo sapiens_hsa000612.53065127
11Nitrogen metabolism_Homo sapiens_hsa009102.36012121
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.27461996
13Pyruvate metabolism_Homo sapiens_hsa006202.27299055
14Butanoate metabolism_Homo sapiens_hsa006502.13998530
15Tryptophan metabolism_Homo sapiens_hsa003802.04575478
16Carbon metabolism_Homo sapiens_hsa012002.01008397
17beta-Alanine metabolism_Homo sapiens_hsa004102.00981640
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.91467247
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90339384
20Peroxisome_Homo sapiens_hsa041461.87929850
21Proteasome_Homo sapiens_hsa030501.84418014
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83079249
23Arginine biosynthesis_Homo sapiens_hsa002201.79899913
24Glycerolipid metabolism_Homo sapiens_hsa005611.78171530
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.76044862
26Fatty acid elongation_Homo sapiens_hsa000621.67161632
27Caffeine metabolism_Homo sapiens_hsa002321.64707561
28Complement and coagulation cascades_Homo sapiens_hsa046101.62535926
29Fat digestion and absorption_Homo sapiens_hsa049751.55451838
30Staphylococcus aureus infection_Homo sapiens_hsa051501.52647687
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50688118
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49809281
33Sulfur metabolism_Homo sapiens_hsa009201.48893939
34Phenylalanine metabolism_Homo sapiens_hsa003601.41184776
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39561197
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36717010
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34463949
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32698841
39Tyrosine metabolism_Homo sapiens_hsa003501.29782733
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29031166
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.28693094
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.27151224
43Sulfur relay system_Homo sapiens_hsa041221.25450420
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18679983
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.15233027
46Chemical carcinogenesis_Homo sapiens_hsa052041.15012642
47TNF signaling pathway_Homo sapiens_hsa046681.14958000
48Rheumatoid arthritis_Homo sapiens_hsa053231.14937013
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.10285047
50Starch and sucrose metabolism_Homo sapiens_hsa005001.10227396
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06692976
52Biosynthesis of amino acids_Homo sapiens_hsa012301.01991809
53AMPK signaling pathway_Homo sapiens_hsa041521.01847675
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99840241
55Histidine metabolism_Homo sapiens_hsa003400.98766444
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98718983
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98175106
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.97221949
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96227071
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94850394
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90338610
62Insulin resistance_Homo sapiens_hsa049310.87104743
63Osteoclast differentiation_Homo sapiens_hsa043800.86567193
64N-Glycan biosynthesis_Homo sapiens_hsa005100.85715961
65Bladder cancer_Homo sapiens_hsa052190.85205496
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84577113
67ABC transporters_Homo sapiens_hsa020100.83691214
68Sphingolipid metabolism_Homo sapiens_hsa006000.83120350
69Mineral absorption_Homo sapiens_hsa049780.81662355
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.81404265
71Bile secretion_Homo sapiens_hsa049760.81113035
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80813502
73Salmonella infection_Homo sapiens_hsa051320.80044880
74Retinol metabolism_Homo sapiens_hsa008300.78880518
75Pentose phosphate pathway_Homo sapiens_hsa000300.77243249
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76950628
77Lysine degradation_Homo sapiens_hsa003100.75871288
78Vibrio cholerae infection_Homo sapiens_hsa051100.73744795
79Allograft rejection_Homo sapiens_hsa053300.72358709
80Asthma_Homo sapiens_hsa053100.70865261
81Vitamin B6 metabolism_Homo sapiens_hsa007500.70470477
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69265174
83Toxoplasmosis_Homo sapiens_hsa051450.67380745
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66960860
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.64540364
86Glucagon signaling pathway_Homo sapiens_hsa049220.63507291
87Hepatitis C_Homo sapiens_hsa051600.63108487
88Apoptosis_Homo sapiens_hsa042100.61788923
89Shigellosis_Homo sapiens_hsa051310.61448504
90Selenocompound metabolism_Homo sapiens_hsa004500.60177892
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58745082
92Tuberculosis_Homo sapiens_hsa051520.58616959
93Insulin signaling pathway_Homo sapiens_hsa049100.58119464
94Phagosome_Homo sapiens_hsa041450.53940499
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51362547
96Legionellosis_Homo sapiens_hsa051340.50805890
97Oxidative phosphorylation_Homo sapiens_hsa001900.50375145
98Influenza A_Homo sapiens_hsa051640.50316832
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49681428
100Fructose and mannose metabolism_Homo sapiens_hsa000510.49609028
101Antigen processing and presentation_Homo sapiens_hsa046120.48334709
102Glutathione metabolism_Homo sapiens_hsa004800.48231338
103Leishmaniasis_Homo sapiens_hsa051400.47598375
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.47168025
105Parkinsons disease_Homo sapiens_hsa050120.42973984
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42033756
107Metabolic pathways_Homo sapiens_hsa011000.41316037
108Graft-versus-host disease_Homo sapiens_hsa053320.39395027
109Viral myocarditis_Homo sapiens_hsa054160.39308561
110Autoimmune thyroid disease_Homo sapiens_hsa053200.38421914
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36959417
112Renin-angiotensin system_Homo sapiens_hsa046140.35181913
113Galactose metabolism_Homo sapiens_hsa000520.34552549
114Folate biosynthesis_Homo sapiens_hsa007900.34512115
115Arginine and proline metabolism_Homo sapiens_hsa003300.33834894
116Alzheimers disease_Homo sapiens_hsa050100.29891851
117Linoleic acid metabolism_Homo sapiens_hsa005910.28620418
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27526531
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.25715213
120Vitamin digestion and absorption_Homo sapiens_hsa049770.23729612
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.23139746
122ECM-receptor interaction_Homo sapiens_hsa045120.22085279
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20342218
124Lysosome_Homo sapiens_hsa041420.19654984
125Ovarian steroidogenesis_Homo sapiens_hsa049130.18599860
126Prion diseases_Homo sapiens_hsa050200.14722734
127Huntingtons disease_Homo sapiens_hsa050160.14306637
128Cardiac muscle contraction_Homo sapiens_hsa042600.10502653
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10271831
130Amoebiasis_Homo sapiens_hsa051460.09400295
131Arachidonic acid metabolism_Homo sapiens_hsa005900.09251429
132Protein digestion and absorption_Homo sapiens_hsa049740.08339433
133Focal adhesion_Homo sapiens_hsa045100.05245050
134HIF-1 signaling pathway_Homo sapiens_hsa040660.03790882
135Type II diabetes mellitus_Homo sapiens_hsa049300.03210133
136Steroid biosynthesis_Homo sapiens_hsa001000.00781599
137Renin secretion_Homo sapiens_hsa04924-0.0315905
138Pertussis_Homo sapiens_hsa05133-0.0271811
139Malaria_Homo sapiens_hsa05144-0.0226275
140Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0210141

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