

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | locomotory exploration behavior (GO:0035641) | 6.24344733 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.15103010 |
| 3 | synaptic vesicle maturation (GO:0016188) | 5.92645328 |
| 4 | neuronal action potential propagation (GO:0019227) | 5.64185446 |
| 5 | cellular potassium ion homeostasis (GO:0030007) | 5.52738709 |
| 6 | glutamate secretion (GO:0014047) | 5.41404793 |
| 7 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.39077916 |
| 8 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.34492172 |
| 9 | synaptic vesicle exocytosis (GO:0016079) | 5.28845791 |
| 10 | sodium ion export (GO:0071436) | 5.23843262 |
| 11 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 5.21886607 |
| 12 | gamma-aminobutyric acid transport (GO:0015812) | 5.15627437 |
| 13 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 5.10858892 |
| 14 | vocalization behavior (GO:0071625) | 5.01300605 |
| 15 | cerebellar granule cell differentiation (GO:0021707) | 4.93437219 |
| 16 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.91058748 |
| 17 | neurotransmitter secretion (GO:0007269) | 4.88961109 |
| 18 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.85870530 |
| 19 | synaptic transmission, glutamatergic (GO:0035249) | 4.84731019 |
| 20 | response to pheromone (GO:0019236) | 4.79433144 |
| 21 | glutamate receptor signaling pathway (GO:0007215) | 4.73185699 |
| 22 | cerebellar Purkinje cell differentiation (GO:0021702) | 4.46419135 |
| 23 | axon ensheathment in central nervous system (GO:0032291) | 4.39311386 |
| 24 | central nervous system myelination (GO:0022010) | 4.39311386 |
| 25 | regulation of synaptic vesicle transport (GO:1902803) | 4.39186918 |
| 26 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.37648183 |
| 27 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.36433674 |
| 28 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 4.31267477 |
| 29 | neuromuscular process controlling posture (GO:0050884) | 4.28916171 |
| 30 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 4.26928476 |
| 31 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.26865774 |
| 32 | long-term memory (GO:0007616) | 4.24193375 |
| 33 | exploration behavior (GO:0035640) | 4.21612297 |
| 34 | cell communication by electrical coupling (GO:0010644) | 4.21368984 |
| 35 | neuron-neuron synaptic transmission (GO:0007270) | 4.19955193 |
| 36 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.16842298 |
| 37 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 4.11057752 |
| 38 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 4.04827822 |
| 39 | proline transport (GO:0015824) | 4.01823108 |
| 40 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.98798955 |
| 41 | L-amino acid import (GO:0043092) | 3.97822841 |
| 42 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.95021933 |
| 43 | potassium ion import (GO:0010107) | 3.93287226 |
| 44 | neurotransmitter transport (GO:0006836) | 3.93248267 |
| 45 | protein localization to synapse (GO:0035418) | 3.92220163 |
| 46 | neuronal ion channel clustering (GO:0045161) | 3.85405445 |
| 47 | layer formation in cerebral cortex (GO:0021819) | 3.84174068 |
| 48 | C4-dicarboxylate transport (GO:0015740) | 3.80630518 |
| 49 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.78246824 |
| 50 | regulation of synapse maturation (GO:0090128) | 3.75264151 |
| 51 | transmission of nerve impulse (GO:0019226) | 3.73863481 |
| 52 | cellular sodium ion homeostasis (GO:0006883) | 3.73063671 |
| 53 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.72345536 |
| 54 | regulation of neurotransmitter levels (GO:0001505) | 3.71465993 |
| 55 | neuromuscular process controlling balance (GO:0050885) | 3.70505055 |
| 56 | positive regulation of synapse maturation (GO:0090129) | 3.67845862 |
| 57 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.66001311 |
| 58 | cell differentiation in hindbrain (GO:0021533) | 3.64001018 |
| 59 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.62372820 |
| 60 | glycine transport (GO:0015816) | 3.58820175 |
| 61 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.57598795 |
| 62 | positive regulation of membrane potential (GO:0045838) | 3.53342413 |
| 63 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.53251338 |
| 64 | regulation of postsynaptic membrane potential (GO:0060078) | 3.52988990 |
| 65 | regulation of synapse structural plasticity (GO:0051823) | 3.52645693 |
| 66 | synaptic vesicle endocytosis (GO:0048488) | 3.51413914 |
| 67 | potassium ion homeostasis (GO:0055075) | 3.50586609 |
| 68 | alanine transport (GO:0032328) | 3.49431126 |
| 69 | neuron cell-cell adhesion (GO:0007158) | 3.46509250 |
| 70 | positive regulation of neurotransmitter transport (GO:0051590) | 3.44677504 |
| 71 | regulation of neurotransmitter secretion (GO:0046928) | 3.43439092 |
| 72 | regulation of synaptic plasticity (GO:0048167) | 3.43128923 |
| 73 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.42067358 |
| 74 | membrane depolarization during action potential (GO:0086010) | 3.41834998 |
| 75 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.38485235 |
| 76 | regulation of beta-amyloid formation (GO:1902003) | 3.31371032 |
| 77 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.31043409 |
| 78 | amino acid import (GO:0043090) | 3.30140140 |
| 79 | long-term synaptic potentiation (GO:0060291) | 3.28317089 |
| 80 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.28073000 |
| 81 | neurotransmitter uptake (GO:0001504) | 3.26069304 |
| 82 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.25452903 |
| 83 | activation of protein kinase A activity (GO:0034199) | 3.25399944 |
| 84 | dendritic spine morphogenesis (GO:0060997) | 3.24538867 |
| 85 | auditory behavior (GO:0031223) | 3.23175617 |
| 86 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.22489049 |
| 87 | response to auditory stimulus (GO:0010996) | 3.22197830 |
| 88 | dendritic spine organization (GO:0097061) | 3.22119185 |
| 89 | membrane depolarization (GO:0051899) | 3.18229695 |
| 90 | regulation of vesicle fusion (GO:0031338) | 3.18161808 |
| 91 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.18073818 |
| 92 | adult walking behavior (GO:0007628) | 3.18048614 |
| 93 | regulation of neurotransmitter transport (GO:0051588) | 3.16263381 |
| 94 | dendrite morphogenesis (GO:0048813) | 3.15916078 |
| 95 | acidic amino acid transport (GO:0015800) | 3.11514733 |
| 96 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.10875231 |
| 97 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.10115919 |
| 98 | membrane hyperpolarization (GO:0060081) | 3.08975276 |
| 99 | long term synaptic depression (GO:0060292) | 3.07651484 |
| 100 | regulation of ARF protein signal transduction (GO:0032012) | 3.07047413 |
| 101 | regulation of exocytosis (GO:0017157) | 3.06000099 |
| 102 | neuromuscular process (GO:0050905) | 3.03437319 |
| 103 | regulation of dendritic spine development (GO:0060998) | 3.01494544 |
| 104 | peptidyl-tyrosine autophosphorylation (GO:0038083) | 3.00406691 |
| 105 | signal complex assembly (GO:0007172) | 2.99989708 |
| 106 | vesicle docking involved in exocytosis (GO:0006904) | 2.99498386 |
| 107 | L-glutamate transport (GO:0015813) | 2.98445818 |
| 108 | negative regulation of hormone metabolic process (GO:0032351) | 2.98195710 |
| 109 | negative regulation of hormone biosynthetic process (GO:0032353) | 2.98195710 |
| 110 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.98140465 |
| 111 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.97357209 |
| 112 | regulation of synaptic transmission (GO:0050804) | 2.95896736 |
| 113 | membrane repolarization (GO:0086009) | 2.93993238 |
| 114 | postsynaptic membrane organization (GO:0001941) | 2.93162622 |
| 115 | synaptic transmission (GO:0007268) | 2.91457132 |
| 116 | establishment of nucleus localization (GO:0040023) | 2.91207548 |
| 117 | positive regulation of dendritic spine development (GO:0060999) | 2.89908243 |
| 118 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 2.89580056 |
| 119 | regulation of amyloid precursor protein catabolic process (GO:1902991) | 2.89227218 |
| 120 | prepulse inhibition (GO:0060134) | 2.87762478 |
| 121 | positive regulation of Rap GTPase activity (GO:0032854) | 2.86543030 |
| 122 | dicarboxylic acid transport (GO:0006835) | 2.81570864 |
| 123 | synaptic vesicle transport (GO:0048489) | 2.78334769 |
| 124 | establishment of synaptic vesicle localization (GO:0097480) | 2.78334769 |
| 125 | regulation of female receptivity (GO:0045924) | 2.76379094 |
| 126 | cell communication involved in cardiac conduction (GO:0086065) | 2.74753392 |
| 127 | positive regulation of synaptic transmission (GO:0050806) | 2.74534024 |
| 128 | positive regulation of dendrite development (GO:1900006) | 2.73408378 |
| 129 | regulation of ARF GTPase activity (GO:0032312) | 2.66388813 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.73459455 |
| 2 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.23957158 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.05264398 |
| 4 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.92009718 |
| 5 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.91347455 |
| 6 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.86086612 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.82129918 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.82129918 |
| 9 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.77514993 |
| 10 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.67535533 |
| 11 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.63592558 |
| 12 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.61659705 |
| 13 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.57828726 |
| 14 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.55494628 |
| 15 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.52497956 |
| 16 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.52295893 |
| 17 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.46938324 |
| 18 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.33074601 |
| 19 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.30999195 |
| 20 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.27916292 |
| 21 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.27096850 |
| 22 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.25061169 |
| 23 | LXR_22292898_ChIP-Seq_THP-1_Human | 2.23132992 |
| 24 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.20122265 |
| 25 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.19115518 |
| 26 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.18005733 |
| 27 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 2.09264208 |
| 28 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.01655368 |
| 29 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.94638833 |
| 30 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.87276529 |
| 31 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.84330678 |
| 32 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.80709887 |
| 33 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.68984845 |
| 34 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.63283885 |
| 35 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.60157579 |
| 36 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.59035341 |
| 37 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.47221124 |
| 38 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.44185754 |
| 39 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.41943332 |
| 40 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.41187226 |
| 41 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.40672106 |
| 42 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.39483776 |
| 43 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.38475952 |
| 44 | P68_20966046_ChIP-Seq_HELA_Human | 1.38087467 |
| 45 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.35162913 |
| 46 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.32772972 |
| 47 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.31811425 |
| 48 | * THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.29505154 |
| 49 | AR_19668381_ChIP-Seq_PC3_Human | 1.28771926 |
| 50 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.26705394 |
| 51 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.26240192 |
| 52 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.26238114 |
| 53 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.22952786 |
| 54 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.22877336 |
| 55 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.22864728 |
| 56 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.22480231 |
| 57 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.21331399 |
| 58 | * PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.20745680 |
| 59 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.20551803 |
| 60 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.18566370 |
| 61 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.17659164 |
| 62 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.17536196 |
| 63 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.17390351 |
| 64 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.17129451 |
| 65 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.16820413 |
| 66 | AR_25329375_ChIP-Seq_VCAP_Human | 1.16498456 |
| 67 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.13176472 |
| 68 | STAT3_23295773_ChIP-Seq_U87_Human | 1.13153636 |
| 69 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.12527816 |
| 70 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.11979305 |
| 71 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.11848430 |
| 72 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.11616773 |
| 73 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.11355823 |
| 74 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.10646464 |
| 75 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.09855043 |
| 76 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.09714025 |
| 77 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.09147963 |
| 78 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.08375410 |
| 79 | TP53_16413492_ChIP-PET_HCT116_Human | 1.07621436 |
| 80 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.05788789 |
| 81 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.04615364 |
| 82 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.03772859 |
| 83 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.03617684 |
| 84 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.03160550 |
| 85 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.03089413 |
| 86 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.02836369 |
| 87 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.02831466 |
| 88 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.02668874 |
| 89 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.02431223 |
| 90 | RXR_22108803_ChIP-Seq_LS180_Human | 1.02089356 |
| 91 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.01735616 |
| 92 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.01356250 |
| 93 | SA1_27219007_Chip-Seq_Bcells_Human | 1.00305762 |
| 94 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.00061160 |
| 95 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.99944693 |
| 96 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.99267989 |
| 97 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.98978443 |
| 98 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.98449676 |
| 99 | P300_19829295_ChIP-Seq_ESCs_Human | 0.98193503 |
| 100 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.96956114 |
| 101 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.96726314 |
| 102 | TCF4_23295773_ChIP-Seq_U87_Human | 0.96352200 |
| 103 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.95939126 |
| 104 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.95763809 |
| 105 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.95697502 |
| 106 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.94865712 |
| 107 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.94418256 |
| 108 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.94230725 |
| 109 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.94206592 |
| 110 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.92687961 |
| 111 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.91377920 |
| 112 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.90986392 |
| 113 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.90913086 |
| 114 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.90787486 |
| 115 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.90300608 |
| 116 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.90270506 |
| 117 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.90189428 |
| 118 | * CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.89976789 |
| 119 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.89679263 |
| 120 | GATA1_19941826_ChIP-Seq_K562_Human | 0.89205625 |
| 121 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.88952601 |
| 122 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.88806470 |
| 123 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.88596206 |
| 124 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.88130497 |
| 125 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.86999078 |
| 126 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.86001473 |
| 127 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.85988951 |
| 128 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.85672647 |
| 129 | SMAD4_21741376_ChIP-Seq_ESCs_Human | 0.85652210 |
| 130 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85571123 |
| 131 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.85560682 |
| 132 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.85411694 |
| 133 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.85204361 |
| 134 | FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.84708844 |
| 135 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.84405365 |
| 136 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.83998627 |
| 137 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.83998404 |
| 138 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.83449855 |
| 139 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.83278691 |
| 140 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.82917468 |
| 141 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.82550933 |
| 142 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.82061590 |
| 143 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.81941620 |
| 144 | SPI1_23127762_ChIP-Seq_K562_Human | 0.81894633 |
| 145 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.81449182 |
| 146 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.81139781 |
| 147 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.81063701 |
| 148 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.81063701 |
| 149 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.81012713 |
| 150 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.80477286 |
| 151 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.79677609 |
| 152 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.79621071 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.63503662 |
| 2 | MP0003635_abnormal_synaptic_transmissio | 4.21895185 |
| 3 | MP0009046_muscle_twitch | 4.08995677 |
| 4 | MP0003880_abnormal_central_pattern | 4.04058510 |
| 5 | MP0009745_abnormal_behavioral_response | 3.42765207 |
| 6 | MP0002064_seizures | 3.35344826 |
| 7 | MP0004270_analgesia | 3.32512010 |
| 8 | MP0002063_abnormal_learning/memory/cond | 3.15345636 |
| 9 | MP0001968_abnormal_touch/_nociception | 2.86673802 |
| 10 | MP0005423_abnormal_somatic_nervous | 2.85462346 |
| 11 | MP0002272_abnormal_nervous_system | 2.85168413 |
| 12 | MP0002572_abnormal_emotion/affect_behav | 2.80049392 |
| 13 | MP0008569_lethality_at_weaning | 2.73293933 |
| 14 | MP0001486_abnormal_startle_reflex | 2.66240443 |
| 15 | MP0002734_abnormal_mechanical_nocicepti | 2.55790432 |
| 16 | MP0001440_abnormal_grooming_behavior | 2.49163289 |
| 17 | MP0001501_abnormal_sleep_pattern | 2.45169470 |
| 18 | MP0003329_amyloid_beta_deposits | 2.35927310 |
| 19 | MP0002736_abnormal_nociception_after | 2.35917717 |
| 20 | MP0002067_abnormal_sensory_capabilities | 2.24880491 |
| 21 | MP0002735_abnormal_chemical_nociception | 2.17202038 |
| 22 | MP0004885_abnormal_endolymph | 1.97711563 |
| 23 | MP0004858_abnormal_nervous_system | 1.95847735 |
| 24 | MP0002733_abnormal_thermal_nociception | 1.92589337 |
| 25 | MP0009780_abnormal_chondrocyte_physiolo | 1.86160652 |
| 26 | MP0005646_abnormal_pituitary_gland | 1.83349772 |
| 27 | MP0003690_abnormal_glial_cell | 1.82127943 |
| 28 | MP0001970_abnormal_pain_threshold | 1.81683115 |
| 29 | MP0003123_paternal_imprinting | 1.80038134 |
| 30 | MP0002557_abnormal_social/conspecific_i | 1.79534667 |
| 31 | MP0002184_abnormal_innervation | 1.76388365 |
| 32 | MP0002909_abnormal_adrenal_gland | 1.72309950 |
| 33 | MP0002822_catalepsy | 1.69455517 |
| 34 | MP0004924_abnormal_behavior | 1.66166350 |
| 35 | MP0005386_behavior/neurological_phenoty | 1.66166350 |
| 36 | MP0004145_abnormal_muscle_electrophysio | 1.59942387 |
| 37 | MP0001502_abnormal_circadian_rhythm | 1.57571438 |
| 38 | MP0000955_abnormal_spinal_cord | 1.56814663 |
| 39 | MP0003633_abnormal_nervous_system | 1.56747916 |
| 40 | MP0003879_abnormal_hair_cell | 1.53655536 |
| 41 | MP0004142_abnormal_muscle_tone | 1.53520520 |
| 42 | MP0004811_abnormal_neuron_physiology | 1.50162943 |
| 43 | MP0002066_abnormal_motor_capabilities/c | 1.48837380 |
| 44 | MP0001984_abnormal_olfaction | 1.45874642 |
| 45 | MP0003631_nervous_system_phenotype | 1.40251690 |
| 46 | MP0000778_abnormal_nervous_system | 1.36972153 |
| 47 | MP0002882_abnormal_neuron_morphology | 1.34913662 |
| 48 | MP0010234_abnormal_vibrissa_follicle | 1.33154171 |
| 49 | MP0005058_abnormal_lysosome_morphology | 1.32465794 |
| 50 | MP0003632_abnormal_nervous_system | 1.31734619 |
| 51 | MP0005166_decreased_susceptibility_to | 1.26579337 |
| 52 | MP0005645_abnormal_hypothalamus_physiol | 1.19163703 |
| 53 | MP0008872_abnormal_physiological_respon | 1.16999321 |
| 54 | MP0002139_abnormal_hepatobiliary_system | 1.16196812 |
| 55 | MP0000604_amyloidosis | 1.15139992 |
| 56 | MP0001765_abnormal_ion_homeostasis | 1.12995476 |
| 57 | MP0002152_abnormal_brain_morphology | 1.10603261 |
| 58 | MP0003787_abnormal_imprinting | 1.08485194 |
| 59 | MP0004043_abnormal_pH_regulation | 1.08244033 |
| 60 | MP0003303_peritoneal_inflammation | 1.08084672 |
| 61 | MP0004742_abnormal_vestibular_system | 1.07254592 |
| 62 | MP0002229_neurodegeneration | 1.05108706 |
| 63 | MP0003075_altered_response_to | 1.04567435 |
| 64 | MP0003283_abnormal_digestive_organ | 0.99415206 |
| 65 | MP0006276_abnormal_autonomic_nervous | 0.98063426 |
| 66 | MP0001986_abnormal_taste_sensitivity | 0.97452316 |
| 67 | MP0005167_abnormal_blood-brain_barrier | 0.96322501 |
| 68 | MP0004215_abnormal_myocardial_fiber | 0.95391678 |
| 69 | MP0000751_myopathy | 0.95064876 |
| 70 | MP0008260_abnormal_autophagy | 0.94495671 |
| 71 | MP0000920_abnormal_myelination | 0.94061927 |
| 72 | MP0003866_abnormal_defecation | 0.93389287 |
| 73 | MP0002069_abnormal_eating/drinking_beha | 0.92567088 |
| 74 | MP0001177_atelectasis | 0.92443523 |
| 75 | MP0005409_darkened_coat_color | 0.91927983 |
| 76 | MP0001485_abnormal_pinna_reflex | 0.91560026 |
| 77 | MP0003634_abnormal_glial_cell | 0.90709387 |
| 78 | MP0005551_abnormal_eye_electrophysiolog | 0.90154641 |
| 79 | MP0008874_decreased_physiological_sensi | 0.87805006 |
| 80 | MP0003137_abnormal_impulse_conducting | 0.87637007 |
| 81 | MP0001963_abnormal_hearing_physiology | 0.85876286 |
| 82 | MP0005535_abnormal_body_temperature | 0.81549289 |
| 83 | MP0001664_abnormal_digestion | 0.79902217 |
| 84 | MP0003191_abnormal_cellular_cholesterol | 0.79861606 |
| 85 | MP0002638_abnormal_pupillary_reflex | 0.79676438 |
| 86 | MP0008961_abnormal_basal_metabolism | 0.77928573 |
| 87 | MP0003122_maternal_imprinting | 0.75726302 |
| 88 | MP0001299_abnormal_eye_distance/ | 0.73877237 |
| 89 | MP0002089_abnormal_postnatal_growth/wei | 0.72497568 |
| 90 | MP0004147_increased_porphyrin_level | 0.71989494 |
| 91 | MP0004085_abnormal_heartbeat | 0.69977465 |
| 92 | MP0001905_abnormal_dopamine_level | 0.68902521 |
| 93 | MP0000013_abnormal_adipose_tissue | 0.67745691 |
| 94 | MP0002752_abnormal_somatic_nervous | 0.64861187 |
| 95 | MP0004130_abnormal_muscle_cell | 0.64644649 |
| 96 | MP0001346_abnormal_lacrimal_gland | 0.63161314 |
| 97 | MP0000569_abnormal_digit_pigmentation | 0.62261096 |
| 98 | MP0000566_synostosis | 0.61893471 |
| 99 | MP0002090_abnormal_vision | 0.61315426 |
| 100 | MP0005394_taste/olfaction_phenotype | 0.60655757 |
| 101 | MP0005499_abnormal_olfactory_system | 0.60655757 |
| 102 | MP0006082_CNS_inflammation | 0.59879375 |
| 103 | MP0010769_abnormal_survival | 0.58563228 |
| 104 | MP0003172_abnormal_lysosome_physiology | 0.57071944 |
| 105 | MP0003436_decreased_susceptibility_to | 0.55568634 |
| 106 | MP0005623_abnormal_meninges_morphology | 0.55504492 |
| 107 | MP0010768_mortality/aging | 0.54922427 |
| 108 | MP0002082_postnatal_lethality | 0.53424316 |
| 109 | MP0010770_preweaning_lethality | 0.53424316 |
| 110 | MP0000747_muscle_weakness | 0.52719594 |
| 111 | MP0004484_altered_response_of | 0.51693214 |
| 112 | MP0004233_abnormal_muscle_weight | 0.51375447 |
| 113 | MP0000631_abnormal_neuroendocrine_gland | 0.49573963 |
| 114 | MP0003956_abnormal_body_size | 0.48906833 |
| 115 | MP0001943_abnormal_respiration | 0.48834400 |
| 116 | MP0003045_fibrosis | 0.48679582 |
| 117 | MP0010386_abnormal_urinary_bladder | 0.47403152 |
| 118 | MP0003183_abnormal_peptide_metabolism | 0.46941316 |
| 119 | MP0004510_myositis | 0.46386916 |
| 120 | MP0001348_abnormal_lacrimal_gland | 0.45795805 |
| 121 | MP0000681_abnormal_thyroid_gland | 0.45690526 |
| 122 | MP0005464_abnormal_platelet_physiology | 0.44594592 |
| 123 | MP0002133_abnormal_respiratory_system | 0.44502561 |
| 124 | MP0005388_respiratory_system_phenotype | 0.44502561 |
| 125 | MP0005310_abnormal_salivary_gland | 0.44071359 |
| 126 | MP0002873_normal_phenotype | 0.43650058 |
| 127 | MP0003638_abnormal_response/metabolism_ | 0.43339457 |
| 128 | MP0004947_skin_inflammation | 0.42553484 |
| 129 | MP0002083_premature_death | 0.42209539 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.58607462 |
| 2 | Myokymia (HP:0002411) | 6.55306077 |
| 3 | Focal seizures (HP:0007359) | 5.82759498 |
| 4 | Visual hallucinations (HP:0002367) | 5.56547789 |
| 5 | Progressive cerebellar ataxia (HP:0002073) | 5.52345225 |
| 6 | Action tremor (HP:0002345) | 5.44376894 |
| 7 | Atonic seizures (HP:0010819) | 4.78180263 |
| 8 | Epileptic encephalopathy (HP:0200134) | 4.68276758 |
| 9 | Febrile seizures (HP:0002373) | 4.60863090 |
| 10 | Gaze-evoked nystagmus (HP:0000640) | 4.43489277 |
| 11 | Hemiplegia (HP:0002301) | 4.29211218 |
| 12 | Dysdiadochokinesis (HP:0002075) | 4.14590256 |
| 13 | Absence seizures (HP:0002121) | 4.09115677 |
| 14 | Generalized tonic-clonic seizures (HP:0002069) | 3.94630642 |
| 15 | Dialeptic seizures (HP:0011146) | 3.73268170 |
| 16 | Hemiparesis (HP:0001269) | 3.71252063 |
| 17 | Abnormality of binocular vision (HP:0011514) | 3.70629103 |
| 18 | Diplopia (HP:0000651) | 3.70629103 |
| 19 | Scanning speech (HP:0002168) | 3.69995902 |
| 20 | Status epilepticus (HP:0002133) | 3.64391318 |
| 21 | Impaired smooth pursuit (HP:0007772) | 3.60622259 |
| 22 | Dysmetria (HP:0001310) | 3.58460095 |
| 23 | Abnormality of the lower motor neuron (HP:0002366) | 3.50454582 |
| 24 | Broad-based gait (HP:0002136) | 3.48298350 |
| 25 | Intention tremor (HP:0002080) | 3.44577439 |
| 26 | Dysmetric saccades (HP:0000641) | 3.41073973 |
| 27 | Supranuclear gaze palsy (HP:0000605) | 3.37731277 |
| 28 | Truncal ataxia (HP:0002078) | 3.35776668 |
| 29 | Poor eye contact (HP:0000817) | 3.35267322 |
| 30 | Abnormality of ocular smooth pursuit (HP:0000617) | 3.33726123 |
| 31 | Obstructive sleep apnea (HP:0002870) | 3.28642615 |
| 32 | Genetic anticipation (HP:0003743) | 3.26156753 |
| 33 | Megalencephaly (HP:0001355) | 3.22862228 |
| 34 | Postural instability (HP:0002172) | 3.21435854 |
| 35 | Depression (HP:0000716) | 3.18400020 |
| 36 | Abnormal eating behavior (HP:0100738) | 3.16335763 |
| 37 | Impaired social interactions (HP:0000735) | 3.13857220 |
| 38 | Abnormal social behavior (HP:0012433) | 3.13857220 |
| 39 | Tetraplegia (HP:0002445) | 3.12551502 |
| 40 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.05028837 |
| 41 | Akinesia (HP:0002304) | 3.05002561 |
| 42 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.94794242 |
| 43 | Aplasia of the phalanges of the hand (HP:0009802) | 2.94794242 |
| 44 | Aplasia involving bones of the extremities (HP:0009825) | 2.94794242 |
| 45 | Ventricular fibrillation (HP:0001663) | 2.92597171 |
| 46 | Delusions (HP:0000746) | 2.92397203 |
| 47 | Ankle clonus (HP:0011448) | 2.87199210 |
| 48 | Metabolic alkalosis (HP:0200114) | 2.85364256 |
| 49 | Apathy (HP:0000741) | 2.81823927 |
| 50 | Anxiety (HP:0000739) | 2.78286156 |
| 51 | Annular pancreas (HP:0001734) | 2.70272881 |
| 52 | Neurofibrillary tangles (HP:0002185) | 2.69921620 |
| 53 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.64507618 |
| 54 | Peripheral hypomyelination (HP:0007182) | 2.59875639 |
| 55 | Cerebral hypomyelination (HP:0006808) | 2.59083304 |
| 56 | Diminished motivation (HP:0000745) | 2.55986933 |
| 57 | Abnormality of saccadic eye movements (HP:0000570) | 2.47416570 |
| 58 | Spastic gait (HP:0002064) | 2.46894943 |
| 59 | Bundle branch block (HP:0011710) | 2.46728887 |
| 60 | Bradykinesia (HP:0002067) | 2.43094657 |
| 61 | Hyperventilation (HP:0002883) | 2.42099886 |
| 62 | Stereotypic behavior (HP:0000733) | 2.38663775 |
| 63 | Limb ataxia (HP:0002070) | 2.35760367 |
| 64 | Mutism (HP:0002300) | 2.29503712 |
| 65 | Cerebral inclusion bodies (HP:0100314) | 2.28813947 |
| 66 | Confusion (HP:0001289) | 2.26590247 |
| 67 | Postural tremor (HP:0002174) | 2.25924826 |
| 68 | Rapidly progressive (HP:0003678) | 2.25320048 |
| 69 | Gait ataxia (HP:0002066) | 2.25216982 |
| 70 | Dementia (HP:0000726) | 2.23133149 |
| 71 | Memory impairment (HP:0002354) | 2.22169983 |
| 72 | Amyloidosis (HP:0011034) | 2.21220849 |
| 73 | Impaired vibratory sensation (HP:0002495) | 2.20820917 |
| 74 | Urinary urgency (HP:0000012) | 2.19018058 |
| 75 | Slow saccadic eye movements (HP:0000514) | 2.17965567 |
| 76 | Hyperactive renin-angiotensin system (HP:0000841) | 2.16518817 |
| 77 | Axonal loss (HP:0003447) | 2.16148806 |
| 78 | Neuronal loss in central nervous system (HP:0002529) | 2.13905680 |
| 79 | Abnormality of renin-angiotensin system (HP:0000847) | 2.11467051 |
| 80 | Lower limb amyotrophy (HP:0007210) | 2.10639499 |
| 81 | Epileptiform EEG discharges (HP:0011182) | 2.10320164 |
| 82 | Amblyopia (HP:0000646) | 2.08914545 |
| 83 | Torticollis (HP:0000473) | 2.06925563 |
| 84 | Focal dystonia (HP:0004373) | 2.06456845 |
| 85 | Clonus (HP:0002169) | 2.05252482 |
| 86 | Rigidity (HP:0002063) | 2.05023764 |
| 87 | Increased cerebral lipofuscin (HP:0011813) | 2.04466225 |
| 88 | EEG with generalized epileptiform discharges (HP:0011198) | 2.03284483 |
| 89 | Insomnia (HP:0100785) | 2.02022546 |
| 90 | Pointed chin (HP:0000307) | 2.01880782 |
| 91 | Limb dystonia (HP:0002451) | 2.00932927 |
| 92 | Spinal canal stenosis (HP:0003416) | 1.99486078 |
| 93 | Psychosis (HP:0000709) | 1.99272404 |
| 94 | Fetal akinesia sequence (HP:0001989) | 1.99216967 |
| 95 | Choreoathetosis (HP:0001266) | 1.99011466 |
| 96 | Lower limb asymmetry (HP:0100559) | 1.98395379 |
| 97 | Drooling (HP:0002307) | 1.96636999 |
| 98 | Excessive salivation (HP:0003781) | 1.96636999 |
| 99 | Split foot (HP:0001839) | 1.96592791 |
| 100 | Incomplete penetrance (HP:0003829) | 1.96422405 |
| 101 | Hypsarrhythmia (HP:0002521) | 1.95891293 |
| 102 | Agitation (HP:0000713) | 1.94834033 |
| 103 | Distal upper limb amyotrophy (HP:0007149) | 1.92894121 |
| 104 | Upper limb amyotrophy (HP:0009129) | 1.92894121 |
| 105 | Abnormality of the corticospinal tract (HP:0002492) | 1.90103543 |
| 106 | Lower limb muscle weakness (HP:0007340) | 1.89645308 |
| 107 | Sleep apnea (HP:0010535) | 1.87994557 |
| 108 | Papilledema (HP:0001085) | 1.86689870 |
| 109 | Horizontal nystagmus (HP:0000666) | 1.86647787 |
| 110 | Generalized myoclonic seizures (HP:0002123) | 1.85879585 |
| 111 | Polygenic inheritance (HP:0010982) | 1.84835295 |
| 112 | Oligodactyly (hands) (HP:0001180) | 1.84100250 |
| 113 | Hyperaldosteronism (HP:0000859) | 1.82200245 |
| 114 | Dysostosis multiplex (HP:0000943) | 1.78985072 |
| 115 | Bronchomalacia (HP:0002780) | 1.77030871 |
| 116 | Heart block (HP:0012722) | 1.75951706 |
| 117 | Syncope (HP:0001279) | 1.74229889 |
| 118 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.74113891 |
| 119 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.74113891 |
| 120 | Hypoplastic nipples (HP:0002557) | 1.73612943 |
| 121 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.73080829 |
| 122 | Slow progression (HP:0003677) | 1.71162777 |
| 123 | Polyphagia (HP:0002591) | 1.70659239 |
| 124 | Narrow nasal bridge (HP:0000446) | 1.70419492 |
| 125 | Craniofacial dystonia (HP:0012179) | 1.69108056 |
| 126 | Progressive inability to walk (HP:0002505) | 1.68468013 |
| 127 | Abnormality of the periventricular white matter (HP:0002518) | 1.67527925 |
| 128 | Spastic tetraparesis (HP:0001285) | 1.67378309 |
| 129 | Clumsiness (HP:0002312) | 1.65445254 |
| 130 | Pheochromocytoma (HP:0002666) | 1.62480619 |
| 131 | Increased circulating renin level (HP:0000848) | 1.62011022 |
| 132 | Abnormal EKG (HP:0003115) | 1.61357436 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.38985162 |
| 2 | EPHA4 | 3.82420849 |
| 3 | MAP3K9 | 3.54727183 |
| 4 | MAP3K4 | 2.82616151 |
| 5 | DAPK2 | 2.78651169 |
| 6 | MINK1 | 2.53577593 |
| 7 | NTRK2 | 2.49883859 |
| 8 | CAMKK1 | 2.37317839 |
| 9 | CAMKK2 | 2.34397906 |
| 10 | PAK6 | 2.29085569 |
| 11 | STK38 | 2.18715892 |
| 12 | MAP2K7 | 2.17569901 |
| 13 | PRKD3 | 2.14018696 |
| 14 | TNIK | 2.02839451 |
| 15 | MAP2K4 | 1.99016091 |
| 16 | MARK1 | 1.88215659 |
| 17 | CDK19 | 1.82748080 |
| 18 | LMTK2 | 1.75280674 |
| 19 | KSR2 | 1.67730676 |
| 20 | RIPK4 | 1.57520760 |
| 21 | RIPK1 | 1.56856803 |
| 22 | PRPF4B | 1.55327075 |
| 23 | MAP3K11 | 1.48679637 |
| 24 | PRKCG | 1.44540319 |
| 25 | CDK5 | 1.44087991 |
| 26 | NTRK1 | 1.43245673 |
| 27 | WNK1 | 1.42714637 |
| 28 | PHKG2 | 1.41570304 |
| 29 | PHKG1 | 1.41570304 |
| 30 | TYRO3 | 1.34454640 |
| 31 | SGK494 | 1.30576839 |
| 32 | SGK223 | 1.30576839 |
| 33 | PINK1 | 1.30326950 |
| 34 | DAPK1 | 1.28053245 |
| 35 | SGK2 | 1.24844980 |
| 36 | PNCK | 1.21664184 |
| 37 | GRK5 | 1.19292783 |
| 38 | MAPK13 | 1.19275921 |
| 39 | OXSR1 | 1.19009741 |
| 40 | CAMK1 | 1.18767921 |
| 41 | SGK3 | 1.15525734 |
| 42 | MAP3K12 | 1.14629977 |
| 43 | CASK | 1.13979931 |
| 44 | MAP3K13 | 1.11643877 |
| 45 | SIK2 | 1.10548372 |
| 46 | PRKCH | 1.08624004 |
| 47 | KSR1 | 1.07070088 |
| 48 | PLK2 | 1.00452697 |
| 49 | STK11 | 0.99213624 |
| 50 | CDK15 | 0.92539029 |
| 51 | PRKG2 | 0.90829614 |
| 52 | CDK18 | 0.90491060 |
| 53 | CDC42BPA | 0.89814723 |
| 54 | TNK2 | 0.89085366 |
| 55 | CAMK2A | 0.88481589 |
| 56 | ALK | 0.87613162 |
| 57 | MAP3K2 | 0.87315981 |
| 58 | UHMK1 | 0.86469216 |
| 59 | FES | 0.83625822 |
| 60 | CDK11A | 0.80344926 |
| 61 | TAOK2 | 0.78059375 |
| 62 | CAMK2B | 0.77222066 |
| 63 | PDK1 | 0.76734822 |
| 64 | DYRK1A | 0.76575243 |
| 65 | ARAF | 0.76125104 |
| 66 | CDK14 | 0.76006578 |
| 67 | TAOK1 | 0.75345852 |
| 68 | SGK1 | 0.75340176 |
| 69 | CAMK4 | 0.74527285 |
| 70 | CAMK2G | 0.73844109 |
| 71 | PDPK1 | 0.73805366 |
| 72 | CAMK1G | 0.73800832 |
| 73 | NEK6 | 0.72592492 |
| 74 | RET | 0.69992857 |
| 75 | PIK3CA | 0.69921006 |
| 76 | MAP2K6 | 0.69194753 |
| 77 | ERN1 | 0.65498411 |
| 78 | MARK2 | 0.61869439 |
| 79 | TESK1 | 0.61682907 |
| 80 | IRAK2 | 0.60644695 |
| 81 | RPS6KA3 | 0.60531745 |
| 82 | PAK3 | 0.59662943 |
| 83 | MAP3K7 | 0.59058840 |
| 84 | DAPK3 | 0.57144704 |
| 85 | MUSK | 0.56861682 |
| 86 | LATS2 | 0.54436854 |
| 87 | PTK2B | 0.54378096 |
| 88 | MAPK12 | 0.54049127 |
| 89 | ERBB2 | 0.52010193 |
| 90 | CAMK2D | 0.50412237 |
| 91 | BRAF | 0.50025856 |
| 92 | JAK2 | 0.49132009 |
| 93 | EPHA2 | 0.48913036 |
| 94 | MST1R | 0.48435041 |
| 95 | NEK1 | 0.45933934 |
| 96 | MAPKAPK5 | 0.45762221 |
| 97 | BRSK1 | 0.45074936 |
| 98 | MAPK10 | 0.44825065 |
| 99 | BMPR2 | 0.43095165 |
| 100 | FYN | 0.41785055 |
| 101 | PKN1 | 0.41494585 |
| 102 | BLK | 0.39182850 |
| 103 | PRKCA | 0.38716639 |
| 104 | PRKCZ | 0.38026565 |
| 105 | PRKG1 | 0.37927417 |
| 106 | MAP3K1 | 0.37848595 |
| 107 | ROCK2 | 0.37792848 |
| 108 | PRKCE | 0.37421371 |
| 109 | FGR | 0.36748552 |
| 110 | SYK | 0.36031203 |
| 111 | JAK1 | 0.34959868 |
| 112 | SRC | 0.34939911 |
| 113 | CSNK1G2 | 0.34753138 |
| 114 | PRKCB | 0.34183754 |
| 115 | BMX | 0.34116894 |
| 116 | RAF1 | 0.33642916 |
| 117 | FER | 0.33370318 |
| 118 | PRKACA | 0.32462607 |
| 119 | TRIB3 | 0.32351478 |
| 120 | PRKACB | 0.32157884 |
| 121 | LIMK1 | 0.29190284 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.19339693 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.12792973 |
| 3 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.84989249 |
| 4 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.84846766 |
| 5 | Long-term potentiation_Homo sapiens_hsa04720 | 2.74369632 |
| 6 | GABAergic synapse_Homo sapiens_hsa04727 | 2.70595142 |
| 7 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.65391391 |
| 8 | Circadian entrainment_Homo sapiens_hsa04713 | 2.64040613 |
| 9 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.47762429 |
| 10 | Morphine addiction_Homo sapiens_hsa05032 | 2.34350065 |
| 11 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.25465431 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.25187645 |
| 13 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.23944634 |
| 14 | Olfactory transduction_Homo sapiens_hsa04740 | 2.22953937 |
| 15 | Insulin secretion_Homo sapiens_hsa04911 | 2.02391537 |
| 16 | Gastric acid secretion_Homo sapiens_hsa04971 | 2.01562878 |
| 17 | Taste transduction_Homo sapiens_hsa04742 | 1.88235538 |
| 18 | Long-term depression_Homo sapiens_hsa04730 | 1.85627287 |
| 19 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.82427361 |
| 20 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.76649863 |
| 21 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.58022926 |
| 22 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.56106705 |
| 23 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.55575924 |
| 24 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.53327530 |
| 25 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.43107590 |
| 26 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.39782895 |
| 27 | Cocaine addiction_Homo sapiens_hsa05030 | 1.31616861 |
| 28 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.29788244 |
| 29 | Renin secretion_Homo sapiens_hsa04924 | 1.28331934 |
| 30 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.28154741 |
| 31 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.27543842 |
| 32 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.23472457 |
| 33 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.21703469 |
| 34 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.19288651 |
| 35 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.16348928 |
| 36 | Pancreatic secretion_Homo sapiens_hsa04972 | 1.14169089 |
| 37 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.14080956 |
| 38 | Bile secretion_Homo sapiens_hsa04976 | 1.09513609 |
| 39 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.08111916 |
| 40 | Gap junction_Homo sapiens_hsa04540 | 1.07829331 |
| 41 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.03996800 |
| 42 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.01205726 |
| 43 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.98668659 |
| 44 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.91737432 |
| 45 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.91524631 |
| 46 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.90606187 |
| 47 | Other glycan degradation_Homo sapiens_hsa00511 | 0.89518563 |
| 48 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.89214004 |
| 49 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.88818682 |
| 50 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.88445999 |
| 51 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.87453218 |
| 52 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.86521934 |
| 53 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.86320016 |
| 54 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.85997400 |
| 55 | Melanogenesis_Homo sapiens_hsa04916 | 0.85918464 |
| 56 | Circadian rhythm_Homo sapiens_hsa04710 | 0.84219189 |
| 57 | Histidine metabolism_Homo sapiens_hsa00340 | 0.81340879 |
| 58 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.81165981 |
| 59 | Glioma_Homo sapiens_hsa05214 | 0.77985437 |
| 60 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.74378111 |
| 61 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.73930191 |
| 62 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.73010813 |
| 63 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.70791222 |
| 64 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.70557432 |
| 65 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.65728022 |
| 66 | Axon guidance_Homo sapiens_hsa04360 | 0.65007701 |
| 67 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.63700186 |
| 68 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.60489618 |
| 69 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.59518504 |
| 70 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.59017722 |
| 71 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.57211284 |
| 72 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.56746279 |
| 73 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.54801852 |
| 74 | Tuberculosis_Homo sapiens_hsa05152 | 0.53596768 |
| 75 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.53273155 |
| 76 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.52103674 |
| 77 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.51199630 |
| 78 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.50837982 |
| 79 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.50713765 |
| 80 | Mineral absorption_Homo sapiens_hsa04978 | 0.49451128 |
| 81 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.46272148 |
| 82 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.44736333 |
| 83 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.43794944 |
| 84 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.42980242 |
| 85 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.41936555 |
| 86 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.41569384 |
| 87 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.40660905 |
| 88 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.39007484 |
| 89 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.38918397 |
| 90 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.38568366 |
| 91 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.37646407 |
| 92 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.37162256 |
| 93 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.36599696 |
| 94 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.36447281 |
| 95 | Platelet activation_Homo sapiens_hsa04611 | 0.36394784 |
| 96 | Leishmaniasis_Homo sapiens_hsa05140 | 0.36320457 |
| 97 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.35822535 |
| 98 | Lysosome_Homo sapiens_hsa04142 | 0.34959388 |
| 99 | Salmonella infection_Homo sapiens_hsa05132 | 0.34872555 |
| 100 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.34763322 |
| 101 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.34621914 |
| 102 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.34392919 |
| 103 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.34169220 |
| 104 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.33013767 |
| 105 | Endocytosis_Homo sapiens_hsa04144 | 0.32828194 |
| 106 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.32336430 |
| 107 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.32027305 |
| 108 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.29383888 |
| 109 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.28861970 |
| 110 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.27509359 |
| 111 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.26686577 |
| 112 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.23450053 |
| 113 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.23212614 |
| 114 | Prion diseases_Homo sapiens_hsa05020 | 0.22229506 |
| 115 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.21491472 |
| 116 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.21020609 |
| 117 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.21006557 |
| 118 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.20448261 |
| 119 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.19343991 |
| 120 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.19256998 |
| 121 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.17514763 |

