AIG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.29739139
2central nervous system myelination (GO:0022010)6.29739139
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.17823541
4L-phenylalanine catabolic process (GO:0006559)6.17823541
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.67828837
6L-phenylalanine metabolic process (GO:0006558)5.67828837
7presynaptic membrane organization (GO:0097090)4.45062855
8blood coagulation, intrinsic pathway (GO:0007597)4.41995874
9presynaptic membrane assembly (GO:0097105)4.19895304
10aromatic amino acid family catabolic process (GO:0009074)4.06205257
11epoxygenase P450 pathway (GO:0019373)4.00022385
12cellular ketone body metabolic process (GO:0046950)3.95571887
13glyoxylate metabolic process (GO:0046487)3.94501598
14protein carboxylation (GO:0018214)3.93250083
15peptidyl-glutamic acid carboxylation (GO:0017187)3.93250083
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.92239222
17exogenous drug catabolic process (GO:0042738)3.90761441
18drug catabolic process (GO:0042737)3.82823117
19protein neddylation (GO:0045116)3.82273308
20fatty acid elongation (GO:0030497)3.80926230
21regulation of fibrinolysis (GO:0051917)3.71013428
22neuron cell-cell adhesion (GO:0007158)3.69574659
23photoreceptor cell differentiation (GO:0046530)3.60733470
24eye photoreceptor cell differentiation (GO:0001754)3.60733470
25regulation of protein activation cascade (GO:2000257)3.58220485
26high-density lipoprotein particle remodeling (GO:0034375)3.56465873
27axoneme assembly (GO:0035082)3.53989465
28reverse cholesterol transport (GO:0043691)3.51356681
29ketone body metabolic process (GO:1902224)3.45327072
30acylglycerol homeostasis (GO:0055090)3.45179752
31triglyceride homeostasis (GO:0070328)3.45179752
32regulation of complement activation (GO:0030449)3.42417453
33xenobiotic catabolic process (GO:0042178)3.41545243
34phenylpropanoid metabolic process (GO:0009698)3.35182408
35long-chain fatty acid biosynthetic process (GO:0042759)3.33476793
36S-adenosylmethionine metabolic process (GO:0046500)3.27418108
37aldehyde catabolic process (GO:0046185)3.27361136
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.26774385
39fibrinolysis (GO:0042730)3.24968033
40regulation of lipoprotein metabolic process (GO:0050746)3.23842965
41neurotransmitter uptake (GO:0001504)3.22121807
42tyrosine metabolic process (GO:0006570)3.21280687
43bile acid biosynthetic process (GO:0006699)3.19368495
44dopamine transport (GO:0015872)3.17254061
45negative regulation of neurotransmitter transport (GO:0051589)3.16696476
46omega-hydroxylase P450 pathway (GO:0097267)3.16084041
47regulation of triglyceride catabolic process (GO:0010896)3.15843735
48water-soluble vitamin biosynthetic process (GO:0042364)3.15598265
49ethanol oxidation (GO:0006069)3.14436439
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12071140
51bile acid metabolic process (GO:0008206)3.08148157
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07420184
53cilium movement (GO:0003341)3.07395478
54myelination (GO:0042552)3.06830689
55serine family amino acid catabolic process (GO:0009071)3.06285729
56neuronal action potential propagation (GO:0019227)3.05149618
57drug metabolic process (GO:0017144)3.04535622
58oxidative demethylation (GO:0070989)3.00382750
59response to redox state (GO:0051775)2.99658542
60axon ensheathment (GO:0008366)2.98503198
61ensheathment of neurons (GO:0007272)2.98503198
62retinal metabolic process (GO:0042574)2.97522717
63neuron remodeling (GO:0016322)2.97202822
64cellular glucuronidation (GO:0052695)2.96400651
65sensory perception of smell (GO:0007608)2.95417013
66protein-lipid complex remodeling (GO:0034368)2.94157204
67macromolecular complex remodeling (GO:0034367)2.94157204
68plasma lipoprotein particle remodeling (GO:0034369)2.94157204
69uronic acid metabolic process (GO:0006063)2.93112736
70glucuronate metabolic process (GO:0019585)2.93112736
71arginine metabolic process (GO:0006525)2.92635137
72negative regulation of fibrinolysis (GO:0051918)2.91129197
73magnesium ion transport (GO:0015693)2.89296559
74detection of calcium ion (GO:0005513)2.89103094
75GPI anchor biosynthetic process (GO:0006506)2.88756580
76gamma-aminobutyric acid signaling pathway (GO:0007214)2.87782843
77protein localization to cilium (GO:0061512)2.87100851
78oligodendrocyte differentiation (GO:0048709)2.85264490
79glycine metabolic process (GO:0006544)2.84170728
80branched-chain amino acid catabolic process (GO:0009083)2.84084409
81amino-acid betaine metabolic process (GO:0006577)2.83727210
82negative regulation of protein activation cascade (GO:2000258)2.82338754
83dopamine biosynthetic process (GO:0042416)2.81239746
84mannosylation (GO:0097502)2.81163465
85cysteine metabolic process (GO:0006534)2.78699768
86GPI anchor metabolic process (GO:0006505)2.73921137
87alpha-amino acid catabolic process (GO:1901606)2.73249579
88ATP synthesis coupled proton transport (GO:0015986)2.72551556
89energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72551556
90negative regulation of protein localization to cell surface (GO:2000009)2.72332244
91negative regulation of cholesterol transport (GO:0032375)2.72131317
92negative regulation of sterol transport (GO:0032372)2.72131317
93regulation of cholesterol esterification (GO:0010872)2.70343941
94postsynaptic membrane organization (GO:0001941)2.69933803
95nucleotide transmembrane transport (GO:1901679)2.69197032
96glycerophospholipid catabolic process (GO:0046475)2.69113921
97aromatic amino acid family metabolic process (GO:0009072)2.68309998
98epithelial cilium movement (GO:0003351)2.66012342
99serine family amino acid metabolic process (GO:0009069)2.65463796
100complement activation, alternative pathway (GO:0006957)2.65285020
101tetrahydrofolate metabolic process (GO:0046653)2.65080862
102intestinal cholesterol absorption (GO:0030299)2.62430710
103regulation of glucokinase activity (GO:0033131)2.62375063
104regulation of hexokinase activity (GO:1903299)2.62375063
105negative regulation of neurotransmitter secretion (GO:0046929)2.61599810
106detection of light stimulus involved in sensory perception (GO:0050962)2.61414050
107detection of light stimulus involved in visual perception (GO:0050908)2.61414050
108negative regulation of complement activation (GO:0045916)2.61044157
109axonemal dynein complex assembly (GO:0070286)2.60040932
110artery smooth muscle contraction (GO:0014824)2.59994465
111platelet dense granule organization (GO:0060155)2.59817586
112phospholipid homeostasis (GO:0055091)2.59243368
113primary alcohol metabolic process (GO:0034308)2.58625468
114amino acid salvage (GO:0043102)2.58330852
115L-methionine salvage (GO:0071267)2.58330852
116L-methionine biosynthetic process (GO:0071265)2.58330852
117ionotropic glutamate receptor signaling pathway (GO:0035235)2.57353921
118terpenoid biosynthetic process (GO:0016114)2.57146835
119low-density lipoprotein particle remodeling (GO:0034374)2.56819937
120positive regulation of synapse assembly (GO:0051965)2.56506870
121coenzyme catabolic process (GO:0009109)2.56139328
122neuron recognition (GO:0008038)2.55683942
123branched-chain amino acid metabolic process (GO:0009081)2.55325329
124transmission of nerve impulse (GO:0019226)2.54775676
125heme transport (GO:0015886)2.54755195
126cellular amino acid catabolic process (GO:0009063)2.54260128
127protein palmitoylation (GO:0018345)2.54153303
128negative regulation of blood coagulation (GO:0030195)2.53878499
129negative regulation of hemostasis (GO:1900047)2.53878499
130mitochondrial respiratory chain complex assembly (GO:0033108)2.53649345
131tonic smooth muscle contraction (GO:0014820)2.53055719
132startle response (GO:0001964)2.52977083
133NADH dehydrogenase complex assembly (GO:0010257)2.52640212
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.52640212
135mitochondrial respiratory chain complex I assembly (GO:0032981)2.52640212
136regulation of collateral sprouting (GO:0048670)2.50543887
137retinol metabolic process (GO:0042572)2.50460332
138bile acid and bile salt transport (GO:0015721)2.50332384
139L-ascorbic acid metabolic process (GO:0019852)2.50204825
140glutamate receptor signaling pathway (GO:0007215)2.50094531
141glutathione derivative biosynthetic process (GO:1901687)2.49383478
142glutathione derivative metabolic process (GO:1901685)2.49383478
143nonmotile primary cilium assembly (GO:0035058)2.47668779
144adult walking behavior (GO:0007628)2.47327693
145synaptic vesicle exocytosis (GO:0016079)2.46330223
146respiratory chain complex IV assembly (GO:0008535)2.45387455
147regulation of catecholamine metabolic process (GO:0042069)2.45088534
148regulation of dopamine metabolic process (GO:0042053)2.45088534
149negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.44567340
150membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44463128
151glutamate secretion (GO:0014047)2.42717909
152signal peptide processing (GO:0006465)2.42520255
153GTP biosynthetic process (GO:0006183)2.42248533
154regulation of synaptic vesicle exocytosis (GO:2000300)2.40721029
155regulation of vesicle fusion (GO:0031338)2.40667412
156regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.40322914
157regulation of neuron projection regeneration (GO:0070570)2.39616035
158regulation of axon regeneration (GO:0048679)2.39616035
159synaptic transmission, glutamatergic (GO:0035249)2.39455227
160apical protein localization (GO:0045176)2.38417020
161preassembly of GPI anchor in ER membrane (GO:0016254)2.37409781
162regulation of short-term neuronal synaptic plasticity (GO:0048172)2.37051110
163photoreceptor cell maintenance (GO:0045494)2.36270623
164nucleoside diphosphate catabolic process (GO:0009134)2.35979874
165cerebral cortex radially oriented cell migration (GO:0021799)2.34164842
166epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.34045199
167intraciliary transport (GO:0042073)2.31375530
168righting reflex (GO:0060013)2.30741885
169calcium-mediated signaling using intracellular calcium source (GO:0035584)2.30738167
170neuron-neuron synaptic transmission (GO:0007270)2.30201262
171regulation of voltage-gated calcium channel activity (GO:1901385)2.28375722
172limb bud formation (GO:0060174)2.28160759
173positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.27919872
174positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.27588564
175vocalization behavior (GO:0071625)2.26989810
176protein complex biogenesis (GO:0070271)2.26846878
177response to epinephrine (GO:0071871)2.26572079
178isoprenoid biosynthetic process (GO:0008299)2.26400506
179G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.26246889
180glycolipid biosynthetic process (GO:0009247)2.23311282
181positive regulation of action potential (GO:0045760)2.22461283
182negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.22287863
183regulation of synaptic vesicle transport (GO:1902803)2.22232980
184cilium morphogenesis (GO:0060271)2.22000681
185long-term synaptic potentiation (GO:0060291)2.21447324
186adult locomotory behavior (GO:0008344)2.21185566
187protein localization to synapse (GO:0035418)2.20474820
188substantia nigra development (GO:0021762)2.19486534
189respiratory electron transport chain (GO:0022904)2.19327135
190cellular potassium ion homeostasis (GO:0030007)2.19312219
191L-amino acid import (GO:0043092)2.17103136
192regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.16583930
193electron transport chain (GO:0022900)2.16448952
194regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.16247755
195neuronal action potential (GO:0019228)2.15525886
196regulation of synaptic transmission, GABAergic (GO:0032228)2.15369598

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.92882969
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.73436905
3EZH2_22144423_ChIP-Seq_EOC_Human3.62975836
4GBX2_23144817_ChIP-Seq_PC3_Human3.58569834
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.15993272
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.09640970
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59507104
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49272010
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47582201
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47273903
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37990408
12TAF15_26573619_Chip-Seq_HEK293_Human2.29182199
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.27066125
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25639698
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21147222
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.21144483
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20165226
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19275248
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15724156
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.15447188
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08398059
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07660864
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07660864
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07055528
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06381541
26HTT_18923047_ChIP-ChIP_STHdh_Human2.05341391
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03203826
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.95725034
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.95268964
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91323220
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88821235
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87264462
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.83520296
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.79230017
35AR_21572438_ChIP-Seq_LNCaP_Human1.79064424
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78518539
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77435993
38P300_19829295_ChIP-Seq_ESCs_Human1.77204211
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76110754
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74699896
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.74503185
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74472190
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.72450301
44VDR_22108803_ChIP-Seq_LS180_Human1.72086201
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68379291
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.66283680
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63791050
48* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63736464
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.63130410
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.61325913
51REST_21632747_ChIP-Seq_MESCs_Mouse1.59983447
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59528647
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57824012
54IGF1R_20145208_ChIP-Seq_DFB_Human1.56615173
55* SMAD4_21799915_ChIP-Seq_A2780_Human1.55121501
56ER_23166858_ChIP-Seq_MCF-7_Human1.51551130
57* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50844061
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49838413
59ZNF274_21170338_ChIP-Seq_K562_Hela1.49296366
60RNF2_27304074_Chip-Seq_NSC_Mouse1.45037029
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.42635555
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39932620
63FUS_26573619_Chip-Seq_HEK293_Human1.39666285
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39289424
65DROSHA_22980978_ChIP-Seq_HELA_Human1.38865367
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38509349
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.37564770
68* EWS_26573619_Chip-Seq_HEK293_Human1.36110085
69ELK1_19687146_ChIP-ChIP_HELA_Human1.35547013
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.35155392
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34824729
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30083997
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28653280
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28616353
75* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28364489
76PHF8_20622853_ChIP-Seq_HELA_Human1.26051283
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24854788
78* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24833028
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24544646
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23307789
81* AR_20517297_ChIP-Seq_VCAP_Human1.23281893
82NANOG_19829295_ChIP-Seq_ESCs_Human1.23185485
83SOX2_19829295_ChIP-Seq_ESCs_Human1.23185485
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.22503713
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.21763241
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21261247
87* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20246149
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20209505
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17461635
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16257899
91* STAT3_23295773_ChIP-Seq_U87_Human1.15649288
92P53_22387025_ChIP-Seq_ESCs_Mouse1.15556132
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15027853
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13815858
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.12589388
96REST_18959480_ChIP-ChIP_MESCs_Mouse1.11798002
97* FOXA1_25329375_ChIP-Seq_VCAP_Human1.11751515
98* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11751515
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.11662650
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11216667
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.11005697
102FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10782432
103CDX2_22108803_ChIP-Seq_LS180_Human1.10334696
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10282934
105STAT3_18555785_Chip-Seq_ESCs_Mouse1.09948959
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09758447
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09680779
108RBPJ_21746931_ChIP-Seq_IB4_Human1.09375361
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08408350
110* HNF4A_19822575_ChIP-Seq_HepG2_Human1.08070362
111P300_18555785_Chip-Seq_ESCs_Mouse1.07454397
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.06704503
113AR_25329375_ChIP-Seq_VCAP_Human1.06412855
114RUNX2_22187159_ChIP-Seq_PCA_Human1.05899961
115HNFA_21074721_ChIP-Seq_CACO-2_Human1.05536835
116* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05483516
117CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04759702
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04753450
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04002336
120CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03984604
121* CRX_20693478_ChIP-Seq_RETINA_Mouse1.03781339
122PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03107156
123SOX2_18555785_Chip-Seq_ESCs_Mouse1.02832733
124TCF4_22108803_ChIP-Seq_LS180_Human1.02456988
125JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02413395
126MYC_18940864_ChIP-ChIP_HL60_Human1.01850097
127LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01276725
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01202654
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01202654
130SALL4_22934838_ChIP-ChIP_CD34+_Human1.01106113
131ETV1_20927104_ChIP-Seq_GIST48_Human1.00878673
132FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00285450
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00252892
134CBP_20019798_ChIP-Seq_JUKART_Human0.99553761
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99553761
136* TCF4_23295773_ChIP-Seq_U87_Human0.99161217
137RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99091249
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98906464
139JUN_21703547_ChIP-Seq_K562_Human0.98848179
140KDM2B_26808549_Chip-Seq_REH_Human0.98227613
141NFYA_21822215_ChIP-Seq_K562_Human0.97757249
142P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97141968
143GATA4_25053715_ChIP-Seq_YYC3_Human0.96420675
144* EZH2_27294783_Chip-Seq_NPCs_Mouse0.96361637
145NMYC_18555785_Chip-Seq_ESCs_Mouse0.95675281
146CBX2_22325352_ChIP-Seq_293T-Rex_Human0.95566889
147IRF1_19129219_ChIP-ChIP_H3396_Human0.95195697
148PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95079058
149MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94978935
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.94881475
151* TP53_18474530_ChIP-ChIP_U2OS_Human0.94444514
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93952181
153BCAT_22108803_ChIP-Seq_LS180_Human0.93894434
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92867807
155PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92729525
156NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91558699
157NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91558699
158AHR_22903824_ChIP-Seq_MCF-7_Human0.91030245

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.32821000
2MP0003880_abnormal_central_pattern4.11640134
3MP0005365_abnormal_bile_salt3.53400827
4MP0005085_abnormal_gallbladder_physiolo3.35893017
5MP0008875_abnormal_xenobiotic_pharmacok3.11852466
6MP0005360_urolithiasis3.02385579
7MP0010329_abnormal_lipoprotein_level2.81187377
8MP0004270_analgesia2.65489982
9MP0001984_abnormal_olfaction2.56620482
10MP0005332_abnormal_amino_acid2.49210447
11MP0002272_abnormal_nervous_system2.48542074
12MP0009697_abnormal_copulation2.38440837
13MP0003122_maternal_imprinting2.34469409
14MP0003635_abnormal_synaptic_transmissio2.34069085
15MP0003136_yellow_coat_color2.32615229
16MP0005171_absent_coat_pigmentation2.30662088
17MP0001486_abnormal_startle_reflex2.28345702
18MP0000920_abnormal_myelination2.24918905
19MP0001188_hyperpigmentation2.22080331
20MP0009745_abnormal_behavioral_response2.20313833
21MP0005423_abnormal_somatic_nervous2.18332944
22MP0004859_abnormal_synaptic_plasticity2.17295482
23MP0002064_seizures2.17021231
24MP0001529_abnormal_vocalization2.16864511
25MP0004019_abnormal_vitamin_homeostasis2.14822390
26MP0005646_abnormal_pituitary_gland2.08737394
27MP0002734_abnormal_mechanical_nocicepti2.08604317
28MP0001968_abnormal_touch/_nociception2.07457282
29MP0002572_abnormal_emotion/affect_behav2.01321001
30MP0002736_abnormal_nociception_after2.00283382
31MP0003186_abnormal_redox_activity1.99020538
32MP0004142_abnormal_muscle_tone1.98021665
33MP0001905_abnormal_dopamine_level1.95500143
34MP0001666_abnormal_nutrient_absorption1.94875552
35MP0006276_abnormal_autonomic_nervous1.94073893
36MP0003011_delayed_dark_adaptation1.93275112
37MP0005551_abnormal_eye_electrophysiolog1.92747533
38MP0009046_muscle_twitch1.92531368
39MP0004742_abnormal_vestibular_system1.92015483
40MP0003252_abnormal_bile_duct1.91406022
41MP0001986_abnormal_taste_sensitivity1.86352869
42MP0002063_abnormal_learning/memory/cond1.81905763
43MP0002735_abnormal_chemical_nociception1.80955653
44MP0003868_abnormal_feces_composition1.80531139
45MP0005645_abnormal_hypothalamus_physiol1.77612369
46MP0004043_abnormal_pH_regulation1.77533800
47MP0001501_abnormal_sleep_pattern1.76538887
48MP0001502_abnormal_circadian_rhythm1.73437870
49MP0002733_abnormal_thermal_nociception1.72086746
50MP0001970_abnormal_pain_threshold1.72074390
51MP0006036_abnormal_mitochondrial_physio1.71560513
52MP0010386_abnormal_urinary_bladder1.67892487
53MP0002067_abnormal_sensory_capabilities1.67781968
54MP0002638_abnormal_pupillary_reflex1.66531218
55MP0001440_abnormal_grooming_behavior1.59259655
56MP0005464_abnormal_platelet_physiology1.58367317
57MP0002118_abnormal_lipid_homeostasis1.55973714
58MP0003123_paternal_imprinting1.55321549
59MP0005636_abnormal_mineral_homeostasis1.54580830
60MP0000778_abnormal_nervous_system1.51897579
61MP0001764_abnormal_homeostasis1.49273380
62MP0005379_endocrine/exocrine_gland_phen1.48108299
63MP0002184_abnormal_innervation1.46838349
64MP0002557_abnormal_social/conspecific_i1.45292757
65MP0004381_abnormal_hair_follicle1.45019962
66MP0003329_amyloid_beta_deposits1.42425463
67MP0003806_abnormal_nucleotide_metabolis1.40511342
68MP0001661_extended_life_span1.39502213
69MP0003718_maternal_effect1.37000248
70MP0002229_neurodegeneration1.32312028
71MP0004924_abnormal_behavior1.31786111
72MP0005386_behavior/neurological_phenoty1.31786111
73MP0001485_abnormal_pinna_reflex1.31734189
74MP0005409_darkened_coat_color1.31054582
75MP0008569_lethality_at_weaning1.29347495
76MP0006072_abnormal_retinal_apoptosis1.28203048
77MP0008872_abnormal_physiological_respon1.28140818
78MP0003634_abnormal_glial_cell1.27067513
79MP0003690_abnormal_glial_cell1.24038256
80MP0002882_abnormal_neuron_morphology1.23855191
81MP0005408_hypopigmentation1.22260900
82MP0003195_calcinosis1.20731983
83MP0000462_abnormal_digestive_system1.17909071
84MP0008775_abnormal_heart_ventricle1.16751494
85MP0002752_abnormal_somatic_nervous1.15679513
86MP0001756_abnormal_urination1.15449747
87MP0003950_abnormal_plasma_membrane1.14836983
88MP0001963_abnormal_hearing_physiology1.14703273
89MP0008877_abnormal_DNA_methylation1.14490568
90MP0000955_abnormal_spinal_cord1.13580484
91MP0006035_abnormal_mitochondrial_morpho1.13388351
92MP0002078_abnormal_glucose_homeostasis1.13281142
93MP0003283_abnormal_digestive_organ1.12725745
94MP0001944_abnormal_pancreas_morphology1.11428786
95MP0001664_abnormal_digestion1.10821149
96MP0004145_abnormal_muscle_electrophysio1.09678399
97MP0000631_abnormal_neuroendocrine_gland1.08095043
98MP0009379_abnormal_foot_pigmentation1.07533058
99MP0000566_synostosis1.06264798
100MP0004215_abnormal_myocardial_fiber1.06083406
101MP0004885_abnormal_endolymph1.04816114
102MP0002066_abnormal_motor_capabilities/c1.04010620
103MP0000372_irregular_coat_pigmentation1.03706489
104MP0006292_abnormal_olfactory_placode1.01522075
105MP0004134_abnormal_chest_morphology1.01339615
106MP0003633_abnormal_nervous_system1.01200841
107MP0005253_abnormal_eye_physiology0.99702963
108MP0003121_genomic_imprinting0.98393167
109MP0000026_abnormal_inner_ear0.97680262
110MP0002132_abnormal_respiratory_system0.97442924
111MP0003953_abnormal_hormone_level0.97094998
112MP0002234_abnormal_pharynx_morphology0.96790483
113MP0004147_increased_porphyrin_level0.96725831
114MP0005187_abnormal_penis_morphology0.96653113
115MP0005670_abnormal_white_adipose0.95666891
116MP0009780_abnormal_chondrocyte_physiolo0.95551873
117MP0005448_abnormal_energy_balance0.93668409
118MP0002090_abnormal_vision0.93164385
119MP0008004_abnormal_stomach_pH0.93140160
120MP0009643_abnormal_urine_homeostasis0.93108505
121MP0005083_abnormal_biliary_tract0.92456753
122MP0002138_abnormal_hepatobiliary_system0.91114024
123MP0003656_abnormal_erythrocyte_physiolo0.90136422
124MP0000609_abnormal_liver_physiology0.89280041
125MP0002876_abnormal_thyroid_physiology0.88045365
126MP0003638_abnormal_response/metabolism_0.87087349
127MP0003631_nervous_system_phenotype0.86379710
128MP0002822_catalepsy0.86214393
129MP0009840_abnormal_foam_cell0.86005718
130MP0005195_abnormal_posterior_eye0.84757084
131MP0002163_abnormal_gland_morphology0.81634899
132MP0009642_abnormal_blood_homeostasis0.80783166
133MP0002938_white_spotting0.75783848
134MP0003632_abnormal_nervous_system0.75281867
135MP0001765_abnormal_ion_homeostasis0.74339111
136MP0000013_abnormal_adipose_tissue0.74296563
137MP0002295_abnormal_pulmonary_circulatio0.73628774
138MP0002971_abnormal_brown_adipose0.73572041
139MP0002693_abnormal_pancreas_physiology0.73294303
140MP0004085_abnormal_heartbeat0.72027247
141MP0008995_early_reproductive_senescence0.71924950
142MP0002102_abnormal_ear_morphology0.71582142
143MP0003879_abnormal_hair_cell0.71511085
144MP0001346_abnormal_lacrimal_gland0.71427470
145MP0000639_abnormal_adrenal_gland0.70540144
146MP0003137_abnormal_impulse_conducting0.70302848
147MP0005084_abnormal_gallbladder_morpholo0.68894573
148MP0000230_abnormal_systemic_arterial0.68892310
149MP0005410_abnormal_fertilization0.68869725
150MP0002909_abnormal_adrenal_gland0.68697509
151MP0005595_abnormal_vascular_smooth0.68204139
152MP0002837_dystrophic_cardiac_calcinosis0.67009701
153MP0003183_abnormal_peptide_metabolism0.66757540
154MP0000647_abnormal_sebaceous_gland0.66378781
155MP0001851_eye_inflammation0.64224795
156MP0005535_abnormal_body_temperature0.63482112

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.96761465
2Abnormal ciliary motility (HP:0012262)4.61597947
3Prolonged partial thromboplastin time (HP:0003645)4.49462433
4Abnormal respiratory motile cilium physiology (HP:0012261)4.15738524
5Hypobetalipoproteinemia (HP:0003563)3.87314871
6Retinal dysplasia (HP:0007973)3.86949465
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.86499986
8Hyperlipoproteinemia (HP:0010980)3.80391345
9Hypothermia (HP:0002045)3.70575748
10Neurofibrillary tangles (HP:0002185)3.65806108
11Abnormal respiratory motile cilium morphology (HP:0005938)3.45481164
12Abnormal respiratory epithelium morphology (HP:0012253)3.45481164
13Focal motor seizures (HP:0011153)3.44761321
14Xanthomatosis (HP:0000991)3.39147923
15Hypoglycemic coma (HP:0001325)3.32781901
16Limb dystonia (HP:0002451)3.19525048
17Menorrhagia (HP:0000132)3.16115655
18Rhinitis (HP:0012384)3.12752686
19Deep venous thrombosis (HP:0002625)3.11626057
20Gait imbalance (HP:0002141)3.07394211
21Cholecystitis (HP:0001082)2.97614290
22Abnormal gallbladder physiology (HP:0012438)2.97614290
23Medial flaring of the eyebrow (HP:0010747)2.96711289
24Joint hemorrhage (HP:0005261)2.96422875
25Degeneration of the lateral corticospinal tracts (HP:0002314)2.96037547
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.96037547
27Hepatic necrosis (HP:0002605)2.94832657
28Hyperglycinemia (HP:0002154)2.88989723
29Congenital primary aphakia (HP:0007707)2.86053415
30Absent/shortened dynein arms (HP:0200106)2.85827443
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.85827443
32Nephrogenic diabetes insipidus (HP:0009806)2.85415029
33Cerebral edema (HP:0002181)2.85015057
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.83155171
35Acute necrotizing encephalopathy (HP:0006965)2.80308782
36Glycosuria (HP:0003076)2.79187979
37Abnormality of urine glucose concentration (HP:0011016)2.79187979
38Ketoacidosis (HP:0001993)2.77884001
39Abnormality of methionine metabolism (HP:0010901)2.76847302
40Genital tract atresia (HP:0001827)2.69916719
41Complement deficiency (HP:0004431)2.69835873
42Vaginal atresia (HP:0000148)2.69702486
43Myokymia (HP:0002411)2.69110475
44Abnormality of the common coagulation pathway (HP:0010990)2.67155324
45Generalized aminoaciduria (HP:0002909)2.66116974
46Acanthocytosis (HP:0001927)2.65583138
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.65540284
48Hypoglycemic seizures (HP:0002173)2.64446641
49Hyperthyroidism (HP:0000836)2.64275596
50Epileptic encephalopathy (HP:0200134)2.64188507
51Abnormal mitochondria in muscle tissue (HP:0008316)2.56693878
52Abnormality of glycolysis (HP:0004366)2.56232576
53Increased serum pyruvate (HP:0003542)2.56205274
54Abnormality of macular pigmentation (HP:0008002)2.55332192
55Poikilocytosis (HP:0004447)2.53917212
56Conjugated hyperbilirubinemia (HP:0002908)2.49494963
57Febrile seizures (HP:0002373)2.48261118
58Hyperinsulinemic hypoglycemia (HP:0000825)2.45879230
59Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.45639742
60Mitochondrial inheritance (HP:0001427)2.44563590
61Lethargy (HP:0001254)2.42190634
62Supranuclear gaze palsy (HP:0000605)2.41258931
63Atonic seizures (HP:0010819)2.41199285
64Abnormality of glycine metabolism (HP:0010895)2.39980031
65Abnormality of serine family amino acid metabolism (HP:0010894)2.39980031
66Intrahepatic cholestasis (HP:0001406)2.38561639
67Pheochromocytoma (HP:0002666)2.38523842
68Parakeratosis (HP:0001036)2.37402702
69Peripheral hypomyelination (HP:0007182)2.37358503
70Ketosis (HP:0001946)2.36431056
71Congenital sensorineural hearing impairment (HP:0008527)2.36294449
72Progressive macrocephaly (HP:0004481)2.34997436
73Abnormal pupillary function (HP:0007686)2.33353613
74Hyperphosphaturia (HP:0003109)2.33274395
75Renal Fanconi syndrome (HP:0001994)2.32760366
76Aplasia/Hypoplasia of the lens (HP:0008063)2.32734702
77Abnormality of serum amino acid levels (HP:0003112)2.30931830
78Vascular calcification (HP:0004934)2.29778931
79Prolonged bleeding time (HP:0003010)2.29564856
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.29106135
81Scanning speech (HP:0002168)2.27961175
82Neuroendocrine neoplasm (HP:0100634)2.26738980
83Abnormality of sulfur amino acid metabolism (HP:0004339)2.25873811
84Type II lissencephaly (HP:0007260)2.25556997
85Hyperglycinuria (HP:0003108)2.24913030
86Epidermoid cyst (HP:0200040)2.24302704
87Central scotoma (HP:0000603)2.23377876
88Cerebral inclusion bodies (HP:0100314)2.23362106
89Lipid accumulation in hepatocytes (HP:0006561)2.22349541
90Abnormality of vitamin metabolism (HP:0100508)2.22332889
91Patchy hypopigmentation of hair (HP:0011365)2.22143626
92Congenital stationary night blindness (HP:0007642)2.19717923
93Abnormal rod and cone electroretinograms (HP:0008323)2.17440223
94Hypolipoproteinemia (HP:0010981)2.17035744
95Thickened helices (HP:0000391)2.16786838
96Hyperventilation (HP:0002883)2.15790658
97Acute encephalopathy (HP:0006846)2.15274264
98Ankle clonus (HP:0011448)2.15255088
99Increased mean platelet volume (HP:0011877)2.13140939
100Spontaneous abortion (HP:0005268)2.11908458
101Pancreatic islet-cell hyperplasia (HP:0004510)2.11212933
102Metabolic alkalosis (HP:0200114)2.11036600
103Nonprogressive disorder (HP:0003680)2.10893240
104Respiratory failure (HP:0002878)2.09469838
105Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.08892378
106Focal seizures (HP:0007359)2.08726371
107Hyperammonemia (HP:0001987)2.06837993
108Agitation (HP:0000713)2.05617209
109Proximal tubulopathy (HP:0000114)2.04895006
110Optic disc pallor (HP:0000543)2.03656688
111Alacrima (HP:0000522)2.03023668
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02979976
113Abnormality of alanine metabolism (HP:0010916)2.02979976
114Hyperalaninemia (HP:0003348)2.02979976
115Purpura (HP:0000979)2.01810883
116True hermaphroditism (HP:0010459)2.01303267
117Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00963269
118Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00963269
119Petechiae (HP:0000967)2.00886632
120Hypomagnesemia (HP:0002917)2.00704875
121Lactic acidosis (HP:0003128)2.00614559
122Abnormality of renal resorption (HP:0011038)2.00522999
123Abnormality of the corticospinal tract (HP:0002492)1.98958961
124Anxiety (HP:0000739)1.96840191
1253-Methylglutaconic aciduria (HP:0003535)1.96448127
126Progressive cerebellar ataxia (HP:0002073)1.96305464
127Abnormality of the intrinsic pathway (HP:0010989)1.95773565
128Metabolic acidosis (HP:0001942)1.95645560
129Dysmetria (HP:0001310)1.94839979
130Palpitations (HP:0001962)1.93747546
131Methylmalonic aciduria (HP:0012120)1.93436077
132Broad-based gait (HP:0002136)1.93035459
133Decreased circulating renin level (HP:0003351)1.92661854
134Hepatocellular necrosis (HP:0001404)1.92391103
135Arthropathy (HP:0003040)1.92131370
136Hypophosphatemic rickets (HP:0004912)1.92003696
137Renal cortical cysts (HP:0000803)1.91786274
138Symptomatic seizures (HP:0011145)1.90968618
139Blue irides (HP:0000635)1.90895574
140Abnormality of the pancreatic islet cells (HP:0006476)1.90607310
141Abnormality of endocrine pancreas physiology (HP:0012093)1.90607310
142Increased circulating renin level (HP:0000848)1.89677990
143Hypoplasia of the fovea (HP:0007750)1.89374075
144Aplasia/Hypoplasia of the fovea (HP:0008060)1.89374075
145Chronic bronchitis (HP:0004469)1.89239983
146Leukodystrophy (HP:0002415)1.89145193
147Fat malabsorption (HP:0002630)1.89050975
148White forelock (HP:0002211)1.88956373
149Cardiovascular calcification (HP:0011915)1.88597575
150Clumsiness (HP:0002312)1.88304814
151Abnormality of calcium-phosphate metabolism (HP:0100530)1.88082637
152Increased serum lactate (HP:0002151)1.87413154
153Abnormality of vitamin B metabolism (HP:0004340)1.87085458
154Abnormality of the renal cortex (HP:0011035)1.85247011
155Pancreatic fibrosis (HP:0100732)1.85108803
156Gingival bleeding (HP:0000225)1.84185906
157Abnormality of the fovea (HP:0000493)1.83689085
158Increased hepatocellular lipid droplets (HP:0006565)1.82816933
159Dialeptic seizures (HP:0011146)1.82432070
160Specific learning disability (HP:0001328)1.81992778
161Abnormal gallbladder morphology (HP:0012437)1.81700012
162Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81352311
163Poor coordination (HP:0002370)1.81192818
164Abnormality of renin-angiotensin system (HP:0000847)1.80882355
165Sensory axonal neuropathy (HP:0003390)1.80519927
166Increased CSF lactate (HP:0002490)1.79799381
167Abnormality of magnesium homeostasis (HP:0004921)1.79496171
168Hyperbilirubinemia (HP:0002904)1.78697952
169Abnormality of midbrain morphology (HP:0002418)1.77371700
170Molar tooth sign on MRI (HP:0002419)1.77371700
171Polyphagia (HP:0002591)1.76445768
172Generalized tonic-clonic seizures (HP:0002069)1.75962116
173Methylmalonic acidemia (HP:0002912)1.74202933
174Absent speech (HP:0001344)1.74117717
175Hypokalemic alkalosis (HP:0001949)1.73927896
176Onion bulb formation (HP:0003383)1.73674403
177Poor speech (HP:0002465)1.72447660
178Spastic gait (HP:0002064)1.71274870
179Absence seizures (HP:0002121)1.71141839
180Atelectasis (HP:0100750)1.70863537
181Humeroradial synostosis (HP:0003041)1.69413863
182Synostosis involving the elbow (HP:0003938)1.69413863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.64415151
2MAPK153.55222291
3CASK3.45138258
4STK393.09393908
5MAP4K23.03941551
6EIF2AK12.83328522
7OXSR12.64390182
8MAPKAPK52.51080386
9MUSK2.48272777
10TNIK2.07678104
11INSRR1.89594788
12NTRK31.89155031
13BMPR1B1.88667118
14MAP2K71.84897933
15NUAK11.76421377
16BMPR21.74261893
17PKN11.69230235
18WNK41.67785454
19ARAF1.67722719
20MARK11.67421553
21PNCK1.64302265
22CDK191.61563979
23EPHA41.60142472
24BCR1.57706334
25GRK71.57235506
26MAPK131.56759705
27CAMK2B1.39255827
28MAPKAPK31.38906826
29PIK3CG1.37683120
30TLK11.37147318
31CAMK2D1.34123585
32NEK61.31404616
33BMX1.30966472
34ADRBK21.30295100
35EPHB11.28703665
36PHKG21.27219984
37PHKG11.27219984
38EIF2AK31.26207407
39BRSK21.25498788
40UHMK11.25379092
41CAMK2A1.23943459
42NEK11.18871123
43ZAK1.17987772
44CSNK1G31.17293287
45NTRK11.17195083
46STK161.16492169
47SGK4941.15909227
48SGK2231.15909227
49STK31.11246037
50BCKDK1.11104367
51PLK31.11018059
52PRKCE1.10555010
53CAMKK21.07347250
54TAOK31.06639955
55MST41.04748105
56CAMK2G1.01495382
57TRIM281.01082282
58FES1.00600574
59IRAK21.00097107
60IRAK10.99984457
61MAP3K120.99155821
62FER0.98293382
63CSNK1G20.98037669
64FGFR20.97447262
65GRK10.96689186
66GRK50.96101402
67CSNK1A1L0.95865753
68PRPF4B0.95000444
69NTRK20.94466106
70CSNK1G10.93531192
71TIE10.92629937
72PINK10.89590157
73HIPK20.87191452
74CDK50.86742615
75WNK30.85151074
76PAK30.84875144
77NME10.83866186
78ERBB30.82720760
79ILK0.82143829
80TRPM70.81923301
81MINK10.81789710
82MAP3K40.81729524
83DYRK1A0.81056087
84CDK30.80720747
85PDK20.80291830
86PLK20.80023152
87WNK10.79476484
88ACVR1B0.78827050
89AKT30.78598136
90DYRK20.77950222
91PAK60.77529953
92MAP2K60.77418481
93PTK2B0.77137507
94PBK0.76030866
95BRAF0.74018517
96ROCK20.72803103
97CCNB10.72187002
98STK240.65492084
99RIPK40.65300912
100PRKG10.65066818
101CAMK10.64505902
102MARK20.64444094
103PRKACG0.62091552
104TTK0.61828404
105PRKACA0.61320948
106PRKCG0.60624779
107TNK20.60224063
108ERBB20.59427869
109PRKCQ0.58803573
110VRK10.58602164
111DAPK20.58583249
112PRKAA20.58433875
113PRKAA10.58113673
114LIMK10.58010976
115MAPK120.56357836
116DMPK0.56256934
117CSNK1E0.55805783
118STK38L0.55610715
119EPHA30.54404877
120MST1R0.52365916
121DAPK30.51057345
122TEC0.48949241
123PRKD20.48806217
124ADRBK10.48331023
125FGR0.47793868
126STK40.47319332
127PRKCH0.46706366
128CAMK1G0.45159765
129CDK80.44909116
130OBSCN0.44838006
131CDC70.44355281
132MYLK0.44242411
133IRAK40.41723856
134MET0.41626426
135MAP3K20.41406549
136PIK3CA0.38309142
137CSNK1A10.38187091
138MAP3K10.37713826
139PRKD10.37505941
140PRKCA0.37472590
141CDK140.37441503
142SIK30.37165591
143MAP3K90.36269722

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.89902393
2Oxidative phosphorylation_Homo sapiens_hsa001902.76557321
3Nicotine addiction_Homo sapiens_hsa050332.48445779
4Fatty acid elongation_Homo sapiens_hsa000622.46049148
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45182008
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.44183332
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.41752647
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25533403
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.25352683
10Sulfur metabolism_Homo sapiens_hsa009202.14306777
11Retinol metabolism_Homo sapiens_hsa008302.11048465
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10595739
13GABAergic synapse_Homo sapiens_hsa047272.10264523
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09709634
15Serotonergic synapse_Homo sapiens_hsa047262.08088903
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03086078
17Caffeine metabolism_Homo sapiens_hsa002322.01446315
18Complement and coagulation cascades_Homo sapiens_hsa046101.98074348
19Parkinsons disease_Homo sapiens_hsa050121.97628596
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.97517051
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.96159168
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96076930
23Collecting duct acid secretion_Homo sapiens_hsa049661.95866153
24Fatty acid degradation_Homo sapiens_hsa000711.90971212
25Taste transduction_Homo sapiens_hsa047421.90768929
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89411679
27Propanoate metabolism_Homo sapiens_hsa006401.88232848
28Morphine addiction_Homo sapiens_hsa050321.88046873
29Chemical carcinogenesis_Homo sapiens_hsa052041.87787263
30Alzheimers disease_Homo sapiens_hsa050101.87423243
31Olfactory transduction_Homo sapiens_hsa047401.85504794
32Glutamatergic synapse_Homo sapiens_hsa047241.81111200
33Phototransduction_Homo sapiens_hsa047441.77931237
34Insulin secretion_Homo sapiens_hsa049111.75614035
35Synaptic vesicle cycle_Homo sapiens_hsa047211.75488137
36Steroid biosynthesis_Homo sapiens_hsa001001.74923801
37Ether lipid metabolism_Homo sapiens_hsa005651.73337042
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69584358
39Circadian entrainment_Homo sapiens_hsa047131.69158842
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.69013458
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.67914904
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.64375763
43Vibrio cholerae infection_Homo sapiens_hsa051101.63431400
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.60762433
45One carbon pool by folate_Homo sapiens_hsa006701.59747424
46Cocaine addiction_Homo sapiens_hsa050301.57476993
47Arginine biosynthesis_Homo sapiens_hsa002201.55161259
48Peroxisome_Homo sapiens_hsa041461.54460832
49Tryptophan metabolism_Homo sapiens_hsa003801.52447583
50Sphingolipid metabolism_Homo sapiens_hsa006001.52367199
51Pyruvate metabolism_Homo sapiens_hsa006201.51059893
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50537064
53Fatty acid metabolism_Homo sapiens_hsa012121.48177777
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46632706
55Amphetamine addiction_Homo sapiens_hsa050311.43744742
56beta-Alanine metabolism_Homo sapiens_hsa004101.34185125
57Fat digestion and absorption_Homo sapiens_hsa049751.34066748
58Salivary secretion_Homo sapiens_hsa049701.33817792
59Dopaminergic synapse_Homo sapiens_hsa047281.31511467
60Huntingtons disease_Homo sapiens_hsa050161.31195686
61Drug metabolism - other enzymes_Homo sapiens_hsa009831.29030401
62Cardiac muscle contraction_Homo sapiens_hsa042601.28846041
63Phenylalanine metabolism_Homo sapiens_hsa003601.24444456
64Starch and sucrose metabolism_Homo sapiens_hsa005001.24066314
65Renin secretion_Homo sapiens_hsa049241.23369910
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22531721
67Pancreatic secretion_Homo sapiens_hsa049721.21369093
68Histidine metabolism_Homo sapiens_hsa003401.19294792
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19026988
70Cysteine and methionine metabolism_Homo sapiens_hsa002701.18136432
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15730092
72Cholinergic synapse_Homo sapiens_hsa047251.15393046
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15101731
74Bile secretion_Homo sapiens_hsa049761.13009837
75Long-term depression_Homo sapiens_hsa047301.12500134
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09640291
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07831574
78Gastric acid secretion_Homo sapiens_hsa049711.07008596
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06693847
80Vitamin B6 metabolism_Homo sapiens_hsa007501.05292997
81Nitrogen metabolism_Homo sapiens_hsa009101.03609330
82PPAR signaling pathway_Homo sapiens_hsa033201.02930712
83Calcium signaling pathway_Homo sapiens_hsa040200.98828241
84Axon guidance_Homo sapiens_hsa043600.97594137
85Rheumatoid arthritis_Homo sapiens_hsa053230.96440600
86Glutathione metabolism_Homo sapiens_hsa004800.95644063
87Linoleic acid metabolism_Homo sapiens_hsa005910.93744090
88Carbon metabolism_Homo sapiens_hsa012000.92250404
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92138259
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90929175
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.90909535
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90411731
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90182010
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87557267
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86579262
96cAMP signaling pathway_Homo sapiens_hsa040240.85812934
97Arachidonic acid metabolism_Homo sapiens_hsa005900.84664794
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84658048
99Long-term potentiation_Homo sapiens_hsa047200.83099867
100Ovarian steroidogenesis_Homo sapiens_hsa049130.81519692
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81480262
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81299007
103Biosynthesis of amino acids_Homo sapiens_hsa012300.77274189
104Butanoate metabolism_Homo sapiens_hsa006500.74323237
105Mineral absorption_Homo sapiens_hsa049780.74108917
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72121576
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.69775617
108Sulfur relay system_Homo sapiens_hsa041220.69169523
109Oxytocin signaling pathway_Homo sapiens_hsa049210.66676477
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66162020
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65043236
112Circadian rhythm_Homo sapiens_hsa047100.62758506
113Glycerolipid metabolism_Homo sapiens_hsa005610.62420545
114Fatty acid biosynthesis_Homo sapiens_hsa000610.61051920
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60261862
116Selenocompound metabolism_Homo sapiens_hsa004500.59551526
117Other glycan degradation_Homo sapiens_hsa005110.58682426
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57939731
119Gap junction_Homo sapiens_hsa045400.56917082
120GnRH signaling pathway_Homo sapiens_hsa049120.55661375
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55148105
122Proteasome_Homo sapiens_hsa030500.53244099
123Fructose and mannose metabolism_Homo sapiens_hsa000510.52927588
124Regulation of autophagy_Homo sapiens_hsa041400.52811790
125Ras signaling pathway_Homo sapiens_hsa040140.52490411
126ABC transporters_Homo sapiens_hsa020100.49565588
127Thyroid hormone synthesis_Homo sapiens_hsa049180.48417640
128Arginine and proline metabolism_Homo sapiens_hsa003300.47425050
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45834236
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44882238
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44140216
132RNA polymerase_Homo sapiens_hsa030200.43732236
133Melanogenesis_Homo sapiens_hsa049160.43726787
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43385394
135Phagosome_Homo sapiens_hsa041450.42047890
136Dilated cardiomyopathy_Homo sapiens_hsa054140.41203933
137Metabolic pathways_Homo sapiens_hsa011000.40330123
138Lysosome_Homo sapiens_hsa041420.39244050
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37427195
140Mismatch repair_Homo sapiens_hsa034300.37080049
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36656545
142Alcoholism_Homo sapiens_hsa050340.35237591
143Autoimmune thyroid disease_Homo sapiens_hsa053200.34626168
144Galactose metabolism_Homo sapiens_hsa000520.34607391
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.33828869
146Renin-angiotensin system_Homo sapiens_hsa046140.33632051
147Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32800783
148Homologous recombination_Homo sapiens_hsa034400.32005838
149Basal transcription factors_Homo sapiens_hsa030220.31290242
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.30704341
151Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30672008
152Purine metabolism_Homo sapiens_hsa002300.30557068
153Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30401913
154Tyrosine metabolism_Homo sapiens_hsa003500.29554522
155Folate biosynthesis_Homo sapiens_hsa007900.26118026
156Vitamin digestion and absorption_Homo sapiens_hsa049770.25022422
157Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25006140
158Ribosome_Homo sapiens_hsa030100.24267071
159Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24163396
160Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23605959

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