AIM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.66146095
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.66146095
3antigen processing and presentation of endogenous antigen (GO:0019883)5.54963723
4detection of other organism (GO:0098543)4.25325346
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.21131493
6detection of bacterium (GO:0016045)4.19438564
7positive regulation of gamma-delta T cell activation (GO:0046645)4.16941740
8NIK/NF-kappaB signaling (GO:0038061)3.98802781
9desmosome organization (GO:0002934)3.84463539
10regulation of interleukin-12 biosynthetic process (GO:0045075)3.83836063
11negative thymic T cell selection (GO:0045060)3.73698587
12negative T cell selection (GO:0043383)3.67374804
13regulation of gamma-delta T cell differentiation (GO:0045586)3.65773989
14macrophage activation involved in immune response (GO:0002281)3.55692421
15hemidesmosome assembly (GO:0031581)3.52962594
16regulation of gamma-delta T cell activation (GO:0046643)3.50753641
17positive regulation of natural killer cell differentiation (GO:0032825)3.49379812
18positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.48339315
19JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.44003735
20thymic T cell selection (GO:0045061)3.41520529
21detection of external biotic stimulus (GO:0098581)3.41119638
22response to type I interferon (GO:0034340)3.40690173
23positive regulation of antigen processing and presentation (GO:0002579)3.38452866
24type I interferon signaling pathway (GO:0060337)3.36834866
25cellular response to type I interferon (GO:0071357)3.36834866
26growth hormone receptor signaling pathway (GO:0060396)3.34719682
27negative regulation of T cell mediated immunity (GO:0002710)3.34349126
28positive thymic T cell selection (GO:0045059)3.33281223
29regulation of T cell tolerance induction (GO:0002664)3.30838569
30B cell receptor signaling pathway (GO:0050853)3.28725976
31response to peptidoglycan (GO:0032494)3.25663012
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.24855854
33positive regulation of interferon-alpha production (GO:0032727)3.23779881
34regulation of interferon-alpha production (GO:0032647)3.21492081
35cellular extravasation (GO:0045123)3.15070457
36B cell mediated immunity (GO:0019724)3.12686151
37hepatocyte apoptotic process (GO:0097284)3.12224231
38T cell selection (GO:0045058)3.12221690
39regulation of hypersensitivity (GO:0002883)3.11210560
40positive regulation of B cell differentiation (GO:0045579)3.08209288
41myeloid dendritic cell differentiation (GO:0043011)3.07695673
42regulation of dendritic cell antigen processing and presentation (GO:0002604)3.00716523
43regulation of water loss via skin (GO:0033561)3.00347462
44interferon-gamma secretion (GO:0072643)3.00214809
45interferon-gamma-mediated signaling pathway (GO:0060333)2.99148636
46regulation of natural killer cell differentiation (GO:0032823)2.97204084
47myeloid dendritic cell activation (GO:0001773)2.96009904
48negative regulation of interleukin-12 production (GO:0032695)2.95833693
49histone H3-K36 demethylation (GO:0070544)2.95688558
50establishment of skin barrier (GO:0061436)2.95116025
51detection of biotic stimulus (GO:0009595)2.91951331
52regulation of antigen processing and presentation (GO:0002577)2.91276737
53T cell migration (GO:0072678)2.88927150
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.88099828
55detection of molecule of bacterial origin (GO:0032490)2.88021847
56response to muramyl dipeptide (GO:0032495)2.88006147
57positive regulation of humoral immune response (GO:0002922)2.86054269
58neutrophil activation involved in immune response (GO:0002283)2.79643952
59regulation of B cell differentiation (GO:0045577)2.79429105
60cellular response to growth hormone stimulus (GO:0071378)2.79048828
61negative regulation of lymphocyte mediated immunity (GO:0002707)2.78600932
62regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78061035
63regulation of type I interferon-mediated signaling pathway (GO:0060338)2.77300680
64tolerance induction (GO:0002507)2.77049625
65regulation of interferon-beta biosynthetic process (GO:0045357)2.74986751
66molting cycle (GO:0042303)2.74845420
67hair cycle (GO:0042633)2.74845420
68T-helper cell differentiation (GO:0042093)2.74394183
69CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.74394183
70phospholipid efflux (GO:0033700)2.73884216
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.73155974
72leukocyte aggregation (GO:0070486)2.72646416
73response to host immune response (GO:0052572)2.72490681
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.72490681
75germinal center formation (GO:0002467)2.71842880
76regulation of response to interferon-gamma (GO:0060330)2.71403213
77immunoglobulin mediated immune response (GO:0016064)2.71171097
78regulation of RIG-I signaling pathway (GO:0039535)2.69923664
79dendritic cell chemotaxis (GO:0002407)2.69576093
80response to host (GO:0075136)2.68804507
81response to host defenses (GO:0052200)2.68804507
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68804507
83antigen processing and presentation via MHC class Ib (GO:0002475)2.68467208
84cellular response to interleukin-15 (GO:0071350)2.68141620
85response to interleukin-15 (GO:0070672)2.67679689
86regulation of alpha-beta T cell proliferation (GO:0046640)2.66996364
87dendritic cell migration (GO:0036336)2.65494279
88positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.65162557
89natural killer cell mediated cytotoxicity (GO:0042267)2.65096743
90natural killer cell mediated immunity (GO:0002228)2.65096743
91interferon-gamma production (GO:0032609)2.63038354
92positive T cell selection (GO:0043368)2.62506511
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62305714
94myeloid cell activation involved in immune response (GO:0002275)2.60357971
95membrane raft organization (GO:0031579)2.59863433
96B cell homeostasis (GO:0001782)2.59552348
97positive regulation of interleukin-2 production (GO:0032743)2.59403532
98negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.57130151
99negative regulation of cell killing (GO:0031342)2.57130151
100neutrophil activation (GO:0042119)2.56794423
101hypotonic response (GO:0006971)2.56720896
102T cell costimulation (GO:0031295)2.55816861
103positive regulation of Cdc42 GTPase activity (GO:0043089)2.55604685
104positive regulation of interleukin-12 production (GO:0032735)2.55324864
105dendritic cell differentiation (GO:0097028)2.55071571
106antigen receptor-mediated signaling pathway (GO:0050851)2.54122689
107regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.54110460
108microglial cell activation (GO:0001774)2.52828220
109negative regulation of leukocyte mediated immunity (GO:0002704)2.51910008
110lymphocyte costimulation (GO:0031294)2.50972422
111keratinization (GO:0031424)2.50680867
112regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.50622541
113cytokine secretion (GO:0050663)2.48976756
114Arp2/3 complex-mediated actin nucleation (GO:0034314)2.48771423
115modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.48448286
116positive regulation by organism of defense response of other organism involved in symbiotic interact2.48448286
117modulation by symbiont of host immune response (GO:0052553)2.48448286
118positive regulation by symbiont of host defense response (GO:0052509)2.48448286
119modulation by symbiont of host defense response (GO:0052031)2.48448286
120modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.48448286
121defense response to protozoan (GO:0042832)2.47943802
122production of molecular mediator of immune response (GO:0002440)2.47936490
123granulocyte activation (GO:0036230)2.47833336
124regulation of B cell receptor signaling pathway (GO:0050855)2.47230807
125positive regulation of cholesterol efflux (GO:0010875)2.46731217
126negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.45676745
127regulation of T cell mediated cytotoxicity (GO:0001914)2.44202489
128regulation of necroptotic process (GO:0060544)2.43825549
129regulation of tolerance induction (GO:0002643)2.43100933
130regulation of cholesterol storage (GO:0010885)2.40534191
131positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.39290730
132alpha-beta T cell differentiation involved in immune response (GO:0002293)2.38071200
133alpha-beta T cell activation involved in immune response (GO:0002287)2.38071200
134T cell differentiation involved in immune response (GO:0002292)2.38071200
135positive regulation of sterol transport (GO:0032373)2.36674317
136positive regulation of cholesterol transport (GO:0032376)2.36674317
137regulation of T-helper 1 cell differentiation (GO:0045625)2.36242899
138keratinocyte differentiation (GO:0030216)2.35747054
139negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.33582067
140T-helper 1 type immune response (GO:0042088)2.32662334
141regulation of interleukin-12 production (GO:0032655)2.31969885
142positive regulation of alpha-beta T cell proliferation (GO:0046641)2.31672903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.54730201
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.90544063
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.83188030
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.71869921
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.62827968
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.23707404
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.12870271
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.90270608
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.87542709
10* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.80103933
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.71934786
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.66035716
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.53017423
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.48468788
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.48271789
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37724906
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34148311
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.31002305
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30389457
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14952076
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.10094155
22RUNX_20019798_ChIP-Seq_JUKART_Human2.09596707
23LXR_22158963_ChIP-Seq_LIVER_Mouse2.03259654
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96500694
25SCL_19346495_ChIP-Seq_HPC-7_Human1.91074266
26* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89837151
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89763309
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.88225592
29* MAF_26560356_Chip-Seq_TH1_Human1.85885573
30* MYB_26560356_Chip-Seq_TH2_Human1.79825697
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79770199
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.76980573
33* FOXO3_23340844_ChIP-Seq_DLD1_Human1.68026513
34* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62459567
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55268670
36MYB_26560356_Chip-Seq_TH1_Human1.55015592
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53866070
38GATA1_22025678_ChIP-Seq_K562_Human1.52491859
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50166678
40TCF7_22412390_ChIP-Seq_EML_Mouse1.46533876
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45241194
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45197060
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45197060
44P63_26484246_Chip-Seq_KERATINOCYTES_Human1.41833420
45* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40761147
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.40079633
47CLOCK_20551151_ChIP-Seq_293T_Human1.39320651
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.36627043
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.32696550
50* MYC_22102868_ChIP-Seq_BL_Human1.32470937
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31377982
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31198912
53FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30758912
54* UTX_26944678_Chip-Seq_JUKART_Human1.29153046
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28760749
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.26072197
57* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25639965
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24197872
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.23251988
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23118964
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22151152
62* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21509433
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20616114
64* VDR_21846776_ChIP-Seq_THP-1_Human1.20071108
65* GATA6_25053715_ChIP-Seq_YYC3_Human1.19774865
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19258626
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18940790
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.18362012
69* VDR_24763502_ChIP-Seq_THP-1_Human1.18236571
70* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17609577
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17067876
72PU_27001747_Chip-Seq_BMDM_Mouse1.16600121
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16036949
74GATA3_27048872_Chip-Seq_THYMUS_Human1.15646104
75* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14346912
76* SOX2_20726797_ChIP-Seq_SW620_Human1.13271326
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.13007876
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12826264
79GATA4_25053715_ChIP-Seq_YYC3_Human1.12800186
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12023318
81* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11816403
82RACK7_27058665_Chip-Seq_MCF-7_Human1.11717785
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11594729
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09656461
85KDM2B_26808549_Chip-Seq_DND41_Human1.09145097
86* VDR_24787735_ChIP-Seq_THP-1_Human1.08773815
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.08211043
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07342585
89MAF_26560356_Chip-Seq_TH2_Human1.06997062
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.05629669
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05599417
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04789136
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04156077
94* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03201252
95SPI1_23547873_ChIP-Seq_NB4_Human1.03045291
96ZNF263_19887448_ChIP-Seq_K562_Human1.02604637
97TRIM28_21343339_ChIP-Seq_HEK293_Human1.01806439
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99621913
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99135655
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98638572
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98310385
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97701292
103EGR1_19032775_ChIP-ChIP_M12_Human0.97063018
104GATA1_19941826_ChIP-Seq_K562_Human0.96456103
105CDX2_20551321_ChIP-Seq_CACO-2_Human0.94120727
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93802085
107UBF1/2_26484160_Chip-Seq_HMECs_Human0.93595507
108* GATA2_19941826_ChIP-Seq_K562_Human0.93096529
109SPI1_23127762_ChIP-Seq_K562_Human0.92123961
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92068598
111RUNX1_27514584_Chip-Seq_MCF-7_Human0.90777858
112ATF3_27146783_Chip-Seq_COLON_Human0.90623923
113* TP63_23658742_ChIP-Seq_EP156T_Human0.89586494
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87620342
115GATA3_26560356_Chip-Seq_TH2_Human0.87422304
116* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86566802
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85974242
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85962886
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85777854
120GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85328677
121CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83337086
122GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83275780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.56558718
2MP0001835_abnormal_antigen_presentation3.00905168
3MP0010234_abnormal_vibrissa_follicle2.82809934
4MP0000685_abnormal_immune_system2.82299008
5MP0002138_abnormal_hepatobiliary_system2.63434814
6MP0004947_skin_inflammation2.61181854
7MP0003300_gastrointestinal_ulcer2.60163074
8MP0003705_abnormal_hypodermis_morpholog2.48740331
9MP0002796_impaired_skin_barrier2.48330553
10MP0003436_decreased_susceptibility_to2.47898258
11MP0001790_abnormal_immune_system2.40993789
12MP0005387_immune_system_phenotype2.40993789
13MP0002166_altered_tumor_susceptibility2.32998582
14MP0005671_abnormal_response_to2.16314755
15MP0009785_altered_susceptibility_to2.15123960
16MP0003763_abnormal_thymus_physiology2.13248563
17MP0001800_abnormal_humoral_immune2.12248906
18MP0004510_myositis2.09203064
19MP0003453_abnormal_keratinocyte_physiol2.08482819
20MP0001873_stomach_inflammation2.05645448
21MP0005000_abnormal_immune_tolerance2.01169751
22MP0003303_peritoneal_inflammation2.00684876
23MP0002006_tumorigenesis1.91718488
24MP0005360_urolithiasis1.90830026
25MP0005025_abnormal_response_to1.89018499
26MP0002148_abnormal_hypersensitivity_rea1.88424291
27MP0010155_abnormal_intestine_physiology1.83730143
28MP0003191_abnormal_cellular_cholesterol1.83586481
29MP0002452_abnormal_antigen_presenting1.83550413
30MP0006082_CNS_inflammation1.80993887
31MP0002723_abnormal_immune_serum1.78301222
32MP0005275_abnormal_skin_tensile1.76056687
33MP0001216_abnormal_epidermal_layer1.72956839
34MP0004264_abnormal_extraembryonic_tissu1.68596268
35MP0005310_abnormal_salivary_gland1.66626268
36MP0010352_gastrointestinal_tract_polyps1.64883805
37MP0003183_abnormal_peptide_metabolism1.63396310
38MP0001819_abnormal_immune_cell1.63231926
39MP0002420_abnormal_adaptive_immunity1.62008033
40MP0002419_abnormal_innate_immunity1.59176705
41MP0009840_abnormal_foam_cell1.57898374
42MP0005501_abnormal_skin_physiology1.57121009
43MP0000579_abnormal_nail_morphology1.56702415
44MP0001853_heart_inflammation1.56364706
45MP0000383_abnormal_hair_follicle1.54306563
46MP0010678_abnormal_skin_adnexa1.53390248
47MP0002060_abnormal_skin_morphology1.49785198
48MP0003724_increased_susceptibility_to1.49620450
49MP0008260_abnormal_autophagy1.49268819
50MP0002098_abnormal_vibrissa_morphology1.47011142
51MP0003566_abnormal_cell_adhesion1.44801995
52MP0002139_abnormal_hepatobiliary_system1.44619059
53MP0002396_abnormal_hematopoietic_system1.44167587
54MP0002405_respiratory_system_inflammati1.44112600
55MP0001845_abnormal_inflammatory_respons1.37733880
56MP0004381_abnormal_hair_follicle1.34227663
57MP0000377_abnormal_hair_follicle1.31948008
58MP0005076_abnormal_cell_differentiation1.31502280
59MP0003828_pulmonary_edema1.31065827
60MP0002009_preneoplasia1.28079030
61MP0001533_abnormal_skeleton_physiology1.26052663
62MP0000716_abnormal_immune_system1.24745472
63MP0001346_abnormal_lacrimal_gland1.23381706
64MP0002398_abnormal_bone_marrow1.22376661
65MP0009333_abnormal_splenocyte_physiolog1.19766478
66MP0005085_abnormal_gallbladder_physiolo1.19638895
67MP0005464_abnormal_platelet_physiology1.17555868
68MP0005451_abnormal_body_composition1.16444903
69MP0003448_altered_tumor_morphology1.15633366
70MP0000703_abnormal_thymus_morphology1.13755126
71MP0003866_abnormal_defecation1.13338573
72MP0005023_abnormal_wound_healing1.12854951
73MP0008469_abnormal_protein_level1.12590661
74MP0009764_decreased_sensitivity_to1.12422284
75MP0005365_abnormal_bile_salt1.11112093
76MP0003252_abnormal_bile_duct1.09802536
77MP0001881_abnormal_mammary_gland1.09089940
78MP0002933_joint_inflammation1.08458516
79MP0002877_abnormal_melanocyte_morpholog1.07138207
80MP0000427_abnormal_hair_cycle1.06960770
81MP0001851_eye_inflammation1.05824637
82MP0000465_gastrointestinal_hemorrhage1.05347859
83MP0008057_abnormal_DNA_replication1.03546427
84MP0000609_abnormal_liver_physiology1.02151726
85MP0000858_altered_metastatic_potential1.01945295
86MP0001243_abnormal_dermal_layer1.01390081
87MP0002722_abnormal_immune_system1.00503359
88MP0001191_abnormal_skin_condition0.99101202
89MP0005409_darkened_coat_color0.97202793
90MP0000689_abnormal_spleen_morphology0.95359363
91MP0002429_abnormal_blood_cell0.95203895
92MP0001666_abnormal_nutrient_absorption0.94305029
93MP0001545_abnormal_hematopoietic_system0.94110647
94MP0005397_hematopoietic_system_phenotyp0.94110647
95MP0009931_abnormal_skin_appearance0.92321240
96MP0000604_amyloidosis0.90802733
97MP0000647_abnormal_sebaceous_gland0.90622521
98MP0000627_abnormal_mammary_gland0.90376718
99MP0010771_integument_phenotype0.90349098
100MP0003941_abnormal_skin_development0.90329147
101MP0001348_abnormal_lacrimal_gland0.90209524
102MP0004883_abnormal_blood_vessel0.87969674
103MP0003045_fibrosis0.87874282
104MP0000569_abnormal_digit_pigmentation0.85555697
105MP0004185_abnormal_adipocyte_glucose0.83748732
106MP0008875_abnormal_xenobiotic_pharmacok0.83653726
107MP0002998_abnormal_bone_remodeling0.83454291
108MP0005058_abnormal_lysosome_morphology0.83446971
109MP0005075_abnormal_melanosome_morpholog0.82076585
110MP0005164_abnormal_response_to0.81423475
111MP0003091_abnormal_cell_migration0.80536092
112MP0000367_abnormal_coat/_hair0.80024582
113MP0005166_decreased_susceptibility_to0.80001640
114MP0009763_increased_sensitivity_to0.79260578
115MP0004782_abnormal_surfactant_physiolog0.79031005
116MP0009115_abnormal_fat_cell0.78899360
117MP0009278_abnormal_bone_marrow0.78605075
118MP0005666_abnormal_adipose_tissue0.78329383
119MP0008961_abnormal_basal_metabolism0.78128356
120MP0010329_abnormal_lipoprotein_level0.77660474
121MP0000490_abnormal_crypts_of0.75316158
122MP0003172_abnormal_lysosome_physiology0.72422687
123MP0000249_abnormal_blood_vessel0.68960311

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.76012912
2Increased IgE level (HP:0003212)4.35257676
3Myocardial infarction (HP:0001658)3.55811294
4Myositis (HP:0100614)3.36290769
5Pustule (HP:0200039)3.35549763
6Milia (HP:0001056)3.34423969
7Recurrent fungal infections (HP:0002841)3.33633787
8Thick nail (HP:0001805)3.33276319
9Plantar hyperkeratosis (HP:0007556)3.32269787
10Elevated erythrocyte sedimentation rate (HP:0003565)3.31693898
11Orchitis (HP:0100796)3.21998427
12Nasal polyposis (HP:0100582)3.15924503
13Chronic otitis media (HP:0000389)3.12054633
14Recurrent bacterial skin infections (HP:0005406)3.09719380
15Right ventricular cardiomyopathy (HP:0011663)3.03745220
16Autoimmune thrombocytopenia (HP:0001973)2.98163762
17Onycholysis (HP:0001806)2.95233636
18Recurrent abscess formation (HP:0002722)2.94623540
19Woolly hair (HP:0002224)2.91728902
20Recurrent viral infections (HP:0004429)2.89896506
21Optic neuritis (HP:0100653)2.85722740
22Retrobulbar optic neuritis (HP:0100654)2.85722740
23Pili torti (HP:0003777)2.84823678
24Abnormality of T cell number (HP:0011839)2.82354523
25Recurrent gram-negative bacterial infections (HP:0005420)2.81577855
26Periodontitis (HP:0000704)2.79992495
27Vasculitis (HP:0002633)2.79805903
28Gangrene (HP:0100758)2.78632540
29Abnormality of the axillary hair (HP:0100134)2.76558095
30Abnormality of secondary sexual hair (HP:0009888)2.76558095
31Palmoplantar hyperkeratosis (HP:0000972)2.76184430
32Gastrointestinal infarctions (HP:0005244)2.72958604
33T lymphocytopenia (HP:0005403)2.71467644
34Fragile nails (HP:0001808)2.68125971
35Abnormality of the nasal mucosa (HP:0000433)2.67932588
36Recurrent cutaneous fungal infections (HP:0011370)2.65752523
37Chronic mucocutaneous candidiasis (HP:0002728)2.65752523
38Malnutrition (HP:0004395)2.64190632
39Arterial thrombosis (HP:0004420)2.63206670
40Gingival bleeding (HP:0000225)2.59731436
41Hypergammaglobulinemia (HP:0010702)2.58634900
42Recurrent skin infections (HP:0001581)2.57011032
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.56719089
44Osteolytic defects of the hand bones (HP:0009699)2.56719089
45Abnormality of nail color (HP:0100643)2.55877142
46Esophageal varix (HP:0002040)2.55736564
47Interstitial pulmonary disease (HP:0006530)2.55658953
48Palmar hyperkeratosis (HP:0010765)2.55380156
49Cellulitis (HP:0100658)2.53594114
50Stomatitis (HP:0010280)2.52095476
51Recurrent bronchitis (HP:0002837)2.50036525
52Alopecia of scalp (HP:0002293)2.47767766
53Erythema (HP:0010783)2.43393035
54Papilloma (HP:0012740)2.42876813
55Verrucae (HP:0200043)2.42876813
56Agammaglobulinemia (HP:0004432)2.42858105
57Osteomyelitis (HP:0002754)2.41979083
58Chronic diarrhea (HP:0002028)2.40722973
59Keratoconjunctivitis (HP:0001096)2.40139564
60Inflammation of the large intestine (HP:0002037)2.38891304
61Abnormality of macrophages (HP:0004311)2.38068501
62Hypotrichosis (HP:0001006)2.38001490
63Xanthomatosis (HP:0000991)2.36128360
64Gastrointestinal stroma tumor (HP:0100723)2.35993863
65Pulmonary infiltrates (HP:0002113)2.35617789
66Gingivitis (HP:0000230)2.35498934
67Xerostomia (HP:0000217)2.34101379
68Abnormality of T cells (HP:0002843)2.33802540
69Deep venous thrombosis (HP:0002625)2.32219258
70Mediastinal lymphadenopathy (HP:0100721)2.31313474
71Abnormal hair laboratory examination (HP:0003328)2.30754534
72Keratoconjunctivitis sicca (HP:0001097)2.30750939
73Skin ulcer (HP:0200042)2.28018142
74Abnormality of monocarboxylic acid metabolism (HP:0010996)2.26962316
75Nail dystrophy (HP:0008404)2.26768618
76Colitis (HP:0002583)2.26231325
77Hematochezia (HP:0002573)2.24938418
78Increased IgM level (HP:0003496)2.24120829
79Autoimmune hemolytic anemia (HP:0001890)2.22509527
80Lip pit (HP:0100267)2.21781761
81Gastrointestinal inflammation (HP:0004386)2.20566234
82Systemic lupus erythematosus (HP:0002725)2.19557684
83Cheilitis (HP:0100825)2.19467153
84Chest pain (HP:0100749)2.16441132
85Encephalitis (HP:0002383)2.14832894
86Peritonitis (HP:0002586)2.11782090
87Sparse scalp hair (HP:0002209)2.11404553
88Abnormality of T cell physiology (HP:0011840)2.11186398
89Joint swelling (HP:0001386)2.08742719
90Abnormal delayed hypersensitivity skin test (HP:0002963)2.08277870
91Hemoptysis (HP:0002105)2.07811206
92Abnormal blistering of the skin (HP:0008066)2.04728052
93Prostate neoplasm (HP:0100787)2.04025071
94Urticaria (HP:0001025)2.03523665
95Granulocytopenia (HP:0001913)2.02763405
96Abnormality of the prostate (HP:0008775)2.01684478
97Eosinophilia (HP:0001880)2.01435045
98Abnormality of the gastric mucosa (HP:0004295)2.00791803
99Panhypogammaglobulinemia (HP:0003139)2.00682456
100Flat acetabular roof (HP:0003180)2.00409584
101Abnormality of cells of the lymphoid lineage (HP:0012140)2.00282653
102Atrophic scars (HP:0001075)1.98738082
103Ridged nail (HP:0001807)1.97957113
104Anorexia (HP:0002039)1.97693442
105Subacute progressive viral hepatitis (HP:0006572)1.97130365
106Viral hepatitis (HP:0006562)1.96797668
107Leukocytosis (HP:0001974)1.96167717
108Pulmonary embolism (HP:0002204)1.95745892
109Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95722746
110Vacuolated lymphocytes (HP:0001922)1.95556804
111Lymphopenia (HP:0001888)1.95271981
112Abnormality of the common coagulation pathway (HP:0010990)1.93616634
113Spontaneous hematomas (HP:0007420)1.93176450
114Sepsis (HP:0100806)1.93146716
115Skin rash (HP:0000988)1.92418228
116Premature loss of primary teeth (HP:0006323)1.91969627
117Congenital ichthyosiform erythroderma (HP:0007431)1.91643685
118Intrahepatic cholestasis (HP:0001406)1.90395487
119Chronic obstructive pulmonary disease (HP:0006510)1.89362655
120Obstructive lung disease (HP:0006536)1.89362655
121Meningitis (HP:0001287)1.88677915
122IgA deficiency (HP:0002720)1.88099335
123Complement deficiency (HP:0004431)1.87862234
124Pruritus (HP:0000989)1.87857235
125Nephritis (HP:0000123)1.87257881
126Emphysema (HP:0002097)1.86935417
127Abnormality of complement system (HP:0005339)1.86534897
128Abnormality of the fingertips (HP:0001211)1.84972243

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.58055102
2TYK23.29883959
3MAP4K13.19290984
4FGFR43.01359424
5JAK32.72231652
6TBK12.62460956
7PRPF4B2.58163922
8IKBKE2.54136254
9ERN12.48504146
10MST42.46747611
11JAK12.38600749
12TXK2.35078798
13EPHB12.19950468
14STK102.16928744
15IKBKB1.98052503
16EPHA31.94912273
17FGFR31.78452549
18SIK11.71520609
19CHUK1.70878543
20BMPR21.70590475
21TRIB31.65470727
22ITK1.59529895
23PTK61.54050919
24TNK21.53836000
25MAP3K131.51323961
26ZAP701.50381526
27BLK1.46999725
28NLK1.44364156
29LRRK21.43315880
30TTN1.39991750
31MST1R1.37277230
32CSK1.35957448
33IRAK41.30877668
34MAP3K31.29341017
35TAOK31.29250164
36MAP3K101.27487050
37RIPK11.26508136
38CDK121.25613365
39SIK31.24070636
40JAK21.22749234
41EPHA21.20502314
42RPS6KA41.18253479
43SMG11.16715120
44LATS11.15136764
45PIM21.14414541
46IRAK31.13669228
47GRK61.11679089
48NEK91.11279818
49PKN21.10338986
50KIT1.06778196
51CDC42BPA1.05470763
52HCK1.03974017
53LCK1.02839747
54BTK1.01044778
55TRPM70.96705061
56TGFBR20.92970136
57EEF2K0.92781415
58MARK20.92708052
59FES0.92302636
60CDK60.92022640
61PIM10.91703673
62FRK0.91568269
63STK240.89344759
64MAP3K20.87070741
65SYK0.86498245
66STK30.83910843
67MELK0.82739279
68MATK0.81222980
69IRAK10.80102008
70CAMK1G0.78545157
71BMX0.77377656
72MAP3K90.75564163
73PDK10.73685378
74CSF1R0.70738937
75KSR20.70378760
76SGK30.69004027
77MAP3K70.68944080
78PRKCQ0.68813761
79NUAK10.68147971
80DYRK1B0.68075753
81TEC0.67671630
82MARK30.66128992
83FER0.65935172
84PRKD20.65083012
85IRAK20.63206555
86WNK10.62271100
87ARAF0.62224961
88EPHB20.61387156
89PDPK10.61211730
90MAPK110.60804514
91NEK60.59132328
92PTK20.58680677
93MAPK70.57819189
94YES10.57574722
95ACVR1B0.57299124
96MAP2K30.56852272
97MAP3K60.56605052
98RIPK40.55535128
99NME20.54074636
100TESK20.52212945
101ABL10.52066409
102MAPKAPK20.51973242
103HIPK20.51846420
104BRD40.51359187
105CAMK1D0.51302403
106MAPKAPK30.51297765
107MOS0.49902356
108SGK20.49517018
109PIK3CA0.47914942
110TGFBR10.47594184
111PRKAA20.46388715
112TESK10.45934561
113EGFR0.45918872
114CDK40.45851008
115RPS6KA10.45623212
116KDR0.44450005
117PDGFRB0.44212076
118MAP3K10.44022915
119PIK3CG0.42280184
120FLT30.41669017
121MAP3K80.41379678
122FGFR10.41169350
123STK40.40429668
124LYN0.40039300
125MAP2K20.40035896
126DMPK0.39774893
127CDK90.39310115
128GSK3A0.36496927
129RPS6KB20.33478882
130RET0.32470201
131TAOK10.31709958
132MAP3K110.31403223
133FGR0.30914067

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.59462084
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.50943249
3Staphylococcus aureus infection_Homo sapiens_hsa051502.39096662
4Primary immunodeficiency_Homo sapiens_hsa053402.37154908
5Leishmaniasis_Homo sapiens_hsa051402.30185134
6Allograft rejection_Homo sapiens_hsa053302.29670630
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19460169
8Measles_Homo sapiens_hsa051622.11250493
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.06089585
10Caffeine metabolism_Homo sapiens_hsa002321.89672630
11Osteoclast differentiation_Homo sapiens_hsa043801.89638572
12Toxoplasmosis_Homo sapiens_hsa051451.89397580
13Graft-versus-host disease_Homo sapiens_hsa053321.88164283
14Antigen processing and presentation_Homo sapiens_hsa046121.82807993
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80659711
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73832743
17T cell receptor signaling pathway_Homo sapiens_hsa046601.69481233
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.63751456
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63548072
20TNF signaling pathway_Homo sapiens_hsa046681.58092212
21Autoimmune thyroid disease_Homo sapiens_hsa053201.52258845
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.49125904
23B cell receptor signaling pathway_Homo sapiens_hsa046621.48322757
24Influenza A_Homo sapiens_hsa051641.46894914
25Pertussis_Homo sapiens_hsa051331.36853033
26Complement and coagulation cascades_Homo sapiens_hsa046101.36032428
27Legionellosis_Homo sapiens_hsa051341.33291545
28Viral myocarditis_Homo sapiens_hsa054161.32622593
29Asthma_Homo sapiens_hsa053101.31894033
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30726111
31Herpes simplex infection_Homo sapiens_hsa051681.29791408
32Apoptosis_Homo sapiens_hsa042101.29182782
33Hematopoietic cell lineage_Homo sapiens_hsa046401.27703275
34Acute myeloid leukemia_Homo sapiens_hsa052211.24005033
35Malaria_Homo sapiens_hsa051441.23568898
36Non-small cell lung cancer_Homo sapiens_hsa052231.23551032
37Hepatitis C_Homo sapiens_hsa051601.23255919
38Tuberculosis_Homo sapiens_hsa051521.23057010
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.19652806
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19391841
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18302298
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18139323
43Arginine biosynthesis_Homo sapiens_hsa002201.14583086
44Small cell lung cancer_Homo sapiens_hsa052221.10941940
45Histidine metabolism_Homo sapiens_hsa003401.04104427
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02886662
47Shigellosis_Homo sapiens_hsa051311.00477840
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00463681
49Chemokine signaling pathway_Homo sapiens_hsa040620.99755994
50Hepatitis B_Homo sapiens_hsa051610.99534001
51Prolactin signaling pathway_Homo sapiens_hsa049170.94992474
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94677496
53Renal cell carcinoma_Homo sapiens_hsa052110.94327054
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93719972
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92949056
56Pancreatic cancer_Homo sapiens_hsa052120.92491099
57Phenylalanine metabolism_Homo sapiens_hsa003600.88569536
58Chronic myeloid leukemia_Homo sapiens_hsa052200.87954169
59ABC transporters_Homo sapiens_hsa020100.87812432
60Nitrogen metabolism_Homo sapiens_hsa009100.87063287
61Adherens junction_Homo sapiens_hsa045200.86397832
62Phagosome_Homo sapiens_hsa041450.86315931
63Tryptophan metabolism_Homo sapiens_hsa003800.85959169
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.85380407
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85247184
66Dorso-ventral axis formation_Homo sapiens_hsa043200.82920011
67Salmonella infection_Homo sapiens_hsa051320.82720796
68Amoebiasis_Homo sapiens_hsa051460.81953915
69PPAR signaling pathway_Homo sapiens_hsa033200.81217396
70Insulin resistance_Homo sapiens_hsa049310.79260582
71Renin-angiotensin system_Homo sapiens_hsa046140.78580570
72Endometrial cancer_Homo sapiens_hsa052130.76486806
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76300877
74Inositol phosphate metabolism_Homo sapiens_hsa005620.75843030
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75513437
76Fatty acid biosynthesis_Homo sapiens_hsa000610.75426860
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.72921384
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.68493195
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67257312
80Proteoglycans in cancer_Homo sapiens_hsa052050.64402820
81Chemical carcinogenesis_Homo sapiens_hsa052040.63952341
82African trypanosomiasis_Homo sapiens_hsa051430.63846667
83Fat digestion and absorption_Homo sapiens_hsa049750.63682334
84Notch signaling pathway_Homo sapiens_hsa043300.63334874
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63285759
86Fatty acid degradation_Homo sapiens_hsa000710.63033946
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61871419
88GnRH signaling pathway_Homo sapiens_hsa049120.59075679
89Rheumatoid arthritis_Homo sapiens_hsa053230.58873365
90mTOR signaling pathway_Homo sapiens_hsa041500.58466254
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58363131
92Choline metabolism in cancer_Homo sapiens_hsa052310.57477019
93HTLV-I infection_Homo sapiens_hsa051660.56269133
94ErbB signaling pathway_Homo sapiens_hsa040120.55669533
95Lysosome_Homo sapiens_hsa041420.54032627
96Viral carcinogenesis_Homo sapiens_hsa052030.53912474
97Retinol metabolism_Homo sapiens_hsa008300.52352342
98Endocytosis_Homo sapiens_hsa041440.50832089
99HIF-1 signaling pathway_Homo sapiens_hsa040660.50478586
100Platelet activation_Homo sapiens_hsa046110.50163928
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49121947
102VEGF signaling pathway_Homo sapiens_hsa043700.47273904
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46463935
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46339941
105MicroRNAs in cancer_Homo sapiens_hsa052060.44844718
106Type I diabetes mellitus_Homo sapiens_hsa049400.44361910
107p53 signaling pathway_Homo sapiens_hsa041150.43690974
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.43461414
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43385515
110Colorectal cancer_Homo sapiens_hsa052100.43022461
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40410083
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40334360
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39784246
114Thyroid cancer_Homo sapiens_hsa052160.39769909
115Bile secretion_Homo sapiens_hsa049760.39680001
116Epstein-Barr virus infection_Homo sapiens_hsa051690.39585097
117Lysine degradation_Homo sapiens_hsa003100.39499271
118Prostate cancer_Homo sapiens_hsa052150.39317969
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38794954
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38237750
121Focal adhesion_Homo sapiens_hsa045100.36927303
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35916900
123Bladder cancer_Homo sapiens_hsa052190.35231045
124Starch and sucrose metabolism_Homo sapiens_hsa005000.34957829
125Other glycan degradation_Homo sapiens_hsa005110.32971846
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.32557691
127FoxO signaling pathway_Homo sapiens_hsa040680.32396272
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.32011796

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