AIM1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)6.77004102
2desmosome organization (GO:0002934)6.66169617
3establishment of skin barrier (GO:0061436)6.26641625
4epidermis development (GO:0008544)5.54241419
5keratinocyte development (GO:0003334)5.48323092
6regulation of water loss via skin (GO:0033561)5.47633256
7gap junction assembly (GO:0016264)5.38416390
8negative regulation of keratinocyte proliferation (GO:0010839)5.35399351
9ectoderm development (GO:0007398)4.61732894
10keratinization (GO:0031424)4.52339577
11hair cycle (GO:0042633)4.28855425
12molting cycle (GO:0042303)4.28855425
13detection of bacterium (GO:0016045)4.22066271
14planar cell polarity pathway involved in neural tube closure (GO:0090179)4.09897146
15sulfate transmembrane transport (GO:1902358)4.09423735
16epithelial cell-cell adhesion (GO:0090136)3.98408198
17establishment of tissue polarity (GO:0007164)3.97027203
18establishment of planar polarity (GO:0001736)3.97027203
19detection of other organism (GO:0098543)3.95679587
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.95481356
21sulfate transport (GO:0008272)3.86890722
22polarized epithelial cell differentiation (GO:0030859)3.86175769
23sphingoid metabolic process (GO:0046519)3.64096967
24ventricular cardiac muscle cell action potential (GO:0086005)3.58151378
25superoxide anion generation (GO:0042554)3.57482871
26estrogen biosynthetic process (GO:0006703)3.56908192
27regulation of chemokine secretion (GO:0090196)3.54011968
28G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.53079271
29intermediate filament cytoskeleton organization (GO:0045104)3.49472157
30regulation of keratinocyte differentiation (GO:0045616)3.41696141
31bundle of His cell to Purkinje myocyte communication (GO:0086069)3.39939097
32multicellular organismal water homeostasis (GO:0050891)3.38910990
33regulation of epidermis development (GO:0045682)3.36711654
34keratinocyte differentiation (GO:0030216)3.34826093
35intermediate filament-based process (GO:0045103)3.31918872
36cell-substrate junction assembly (GO:0007044)3.31883761
37surfactant homeostasis (GO:0043129)3.28042886
38positive regulation of Cdc42 GTPase activity (GO:0043089)3.26730536
39regulation of epidermal cell differentiation (GO:0045604)3.23917778
40oligosaccharide catabolic process (GO:0009313)3.23081297
41regulation of hair follicle development (GO:0051797)3.22719293
42regulation of interleukin-8 secretion (GO:2000482)3.20454380
43regulation of keratinocyte proliferation (GO:0010837)3.20037941
44eyelid development in camera-type eye (GO:0061029)3.17505002
45atrioventricular valve morphogenesis (GO:0003181)3.16297661
46positive regulation of interleukin-8 secretion (GO:2000484)3.15326628
47lipoxygenase pathway (GO:0019372)3.14881503
48negative regulation of epidermis development (GO:0045683)3.12925231
49negative regulation of cell fate specification (GO:0009996)3.10665810
50positive regulation of epidermal cell differentiation (GO:0045606)3.09900399
51regulation of cardioblast differentiation (GO:0051890)3.09294077
52interferon-gamma secretion (GO:0072643)3.08516925
53regulation of cholesterol homeostasis (GO:2000188)3.08059726
54dendritic cell chemotaxis (GO:0002407)3.07073281
55diol metabolic process (GO:0034311)3.04599878
56cell-cell junction assembly (GO:0007043)3.01637162
57cyclooxygenase pathway (GO:0019371)2.98673771
58sphingosine metabolic process (GO:0006670)2.98014247
59regulation of vitamin metabolic process (GO:0030656)2.97348851
60regulation of ruffle assembly (GO:1900027)2.92819594
61intermediate filament organization (GO:0045109)2.91991167
62doxorubicin metabolic process (GO:0044598)2.91596081
63daunorubicin metabolic process (GO:0044597)2.91596081
64polyketide metabolic process (GO:0030638)2.91596081
65cytoskeletal anchoring at plasma membrane (GO:0007016)2.91231710
66keratinocyte proliferation (GO:0043616)2.90685323
67dendritic cell migration (GO:0036336)2.89795764
68response to UV-B (GO:0010224)2.89749516
69protein complex localization (GO:0031503)2.88259598
70hemidesmosome assembly (GO:0031581)2.88237430
71adenosine metabolic process (GO:0046085)2.86658487
72activation of Rac GTPase activity (GO:0032863)2.85814997
73tight junction assembly (GO:0070830)2.85570606
74regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.85370583
75positive regulation of interleukin-1 beta secretion (GO:0050718)2.83874160
76regulation of transforming growth factor beta1 production (GO:0032908)2.83419029
77CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.82877279
78T-helper cell differentiation (GO:0042093)2.82877279
79negative regulation of stem cell proliferation (GO:2000647)2.82267274
80epithelial cell differentiation involved in prostate gland development (GO:0060742)2.80700962
81citrulline biosynthetic process (GO:0019240)2.79451632
82regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78241340
83phosphatidylserine acyl-chain remodeling (GO:0036150)2.77896524
84regulation of hair cycle (GO:0042634)2.77513463
85chemical homeostasis within a tissue (GO:0048875)2.76967758
86positive regulation of interleukin-1 secretion (GO:0050716)2.76525230
87regulation of heart rate by cardiac conduction (GO:0086091)2.76215921
88skin development (GO:0043588)2.75526922
89regulation of transforming growth factor beta2 production (GO:0032909)2.74757516
90linoleic acid metabolic process (GO:0043651)2.73840907
91negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.73637388
92trophectodermal cell differentiation (GO:0001829)2.70445058
93water homeostasis (GO:0030104)2.69908657
94positive regulation of hair follicle development (GO:0051798)2.68133937
95positive regulation of hair cycle (GO:0042635)2.68133937
96epithelium development (GO:0060429)2.67676058
974-hydroxyproline metabolic process (GO:0019471)2.67630781
98cellular protein complex localization (GO:0034629)2.65505255
99endosome organization (GO:0007032)2.65053490
100morphogenesis of embryonic epithelium (GO:0016331)2.64344304
101cellular anion homeostasis (GO:0030002)2.63870017
102regulation of G0 to G1 transition (GO:0070316)2.63673374
103cell differentiation involved in embryonic placenta development (GO:0060706)2.63418335
104phospholipid scrambling (GO:0017121)2.63400846
105regulation of interleukin-1 beta secretion (GO:0050706)2.63152418
106ceramide catabolic process (GO:0046514)2.63050909
107negative regulation of mast cell activation (GO:0033004)2.62554794
108replicative senescence (GO:0090399)2.61718379
109protein K6-linked ubiquitination (GO:0085020)2.59840688
110intestinal cholesterol absorption (GO:0030299)2.59111374
111long-chain fatty acid biosynthetic process (GO:0042759)2.58861726
112purinergic nucleotide receptor signaling pathway (GO:0035590)2.58711070
113skin morphogenesis (GO:0043589)2.58591410
114alpha-beta T cell differentiation involved in immune response (GO:0002293)2.58224478
115alpha-beta T cell activation involved in immune response (GO:0002287)2.58224478
116T cell differentiation involved in immune response (GO:0002292)2.58224478
117branching involved in labyrinthine layer morphogenesis (GO:0060670)2.58217670
118regulation of RIG-I signaling pathway (GO:0039535)2.57266350
119mesenchymal cell differentiation involved in kidney development (GO:0072161)2.56700179
120mesenchymal cell differentiation involved in renal system development (GO:2001012)2.56700179
121response to follicle-stimulating hormone (GO:0032354)2.55993302
122cytidine metabolic process (GO:0046087)2.55310356
123cytidine catabolic process (GO:0006216)2.55310356
124cytidine deamination (GO:0009972)2.55310356
125notochord development (GO:0030903)2.55210764
126protein autoprocessing (GO:0016540)2.53796244
127positive regulation of epidermis development (GO:0045684)2.53579238
128detection of external biotic stimulus (GO:0098581)2.53292455
129glucosamine-containing compound catabolic process (GO:1901072)2.53010481
130L-alpha-amino acid transmembrane transport (GO:1902475)2.52415285
131positive regulation of chemokine secretion (GO:0090197)2.51582084
132epidermal cell differentiation (GO:0009913)2.48797465
133Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.47905330
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.47552585
135tRNA methylation (GO:0030488)2.47402485
136cell communication involved in cardiac conduction (GO:0086065)2.47228718
137hippo signaling (GO:0035329)2.46386233
138regulation of establishment of planar polarity (GO:0090175)2.46173624
139calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.45365830
140regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.42090234
141phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.41584910
142L-serine metabolic process (GO:0006563)2.39746384
143female pregnancy (GO:0007565)2.39232487
144amino sugar catabolic process (GO:0046348)2.37553887
145cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.36762843
146negative regulation of epidermal cell differentiation (GO:0045605)2.36730701
147cardiac right ventricle morphogenesis (GO:0003215)2.35635570
148branching involved in mammary gland duct morphogenesis (GO:0060444)2.34968680
149positive regulation of interleukin-1 beta production (GO:0032731)2.34743925
150CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.34034277
151apical protein localization (GO:0045176)2.33622403
152energy homeostasis (GO:0097009)2.33017037
153histamine secretion (GO:0001821)2.31856122
154intestinal epithelial cell development (GO:0060576)2.31450119
155centriole assembly (GO:0098534)2.31165284
156eosinophil chemotaxis (GO:0048245)2.30504990
1573-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.30476613
158purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.30476613
159transepithelial transport (GO:0070633)2.29374062
160DNA integration (GO:0015074)2.29266191
161intestinal absorption (GO:0050892)2.28861026
162regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.28342048
163non-canonical Wnt signaling pathway (GO:0035567)2.27936441
164DNA deamination (GO:0045006)2.27312910
165positive regulation of antigen processing and presentation (GO:0002579)2.26776332
166regulation of interleukin-1 secretion (GO:0050704)2.26657150
167meiotic chromosome segregation (GO:0045132)2.23797728
168positive regulation of uterine smooth muscle contraction (GO:0070474)2.22697309
169superoxide metabolic process (GO:0006801)2.22661980
170regulation of cell proliferation involved in kidney development (GO:1901722)2.22570564
171negative regulation of homotypic cell-cell adhesion (GO:0034111)2.22274584
172poly(A)+ mRNA export from nucleus (GO:0016973)2.22100870
173interferon-gamma production (GO:0032609)2.22052397
174negative regulation of DNA-dependent DNA replication (GO:2000104)2.21903911
175T cell activation involved in immune response (GO:0002286)2.21338192
176positive regulation of keratinocyte differentiation (GO:0045618)2.21231754
177CD4-positive, alpha-beta T cell activation (GO:0035710)2.20149196

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.77497466
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.35552943
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.25322125
4ZNF263_19887448_ChIP-Seq_K562_Human2.86506266
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.77238252
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.75455925
7E2F7_22180533_ChIP-Seq_HELA_Human2.63722921
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.61507234
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.58213727
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.56385211
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.48486971
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.48338333
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41473388
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.40343128
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.33226957
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.32593679
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.31765781
18SUZ12_27294783_Chip-Seq_NPCs_Mouse2.30726106
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.30027742
20KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.20456505
21VDR_22108803_ChIP-Seq_LS180_Human2.17539733
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.16908698
23RACK7_27058665_Chip-Seq_MCF-7_Human2.14379597
24CDX2_20551321_ChIP-Seq_CACO-2_Human2.13185276
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11135808
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07568091
27AR_21909140_ChIP-Seq_LNCAP_Human1.93772135
28ATF3_27146783_Chip-Seq_COLON_Human1.91853834
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87267075
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.85453303
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84829542
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.83783095
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77874581
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75757662
35GATA6_25053715_ChIP-Seq_YYC3_Human1.71601560
36STAT3_18555785_Chip-Seq_ESCs_Mouse1.70776560
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66948324
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.64888548
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64655501
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.64241710
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61625690
42SUZ12_18555785_Chip-Seq_ESCs_Mouse1.61316869
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.61051360
44NMYC_18555785_Chip-Seq_ESCs_Mouse1.59409946
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58091804
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.57588336
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.57518201
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.57223729
49KAP1_22055183_ChIP-Seq_ESCs_Mouse1.56930174
50P53_22387025_ChIP-Seq_ESCs_Mouse1.55868600
51RUNX1_27514584_Chip-Seq_MCF-7_Human1.55675393
52RUNX1_27457419_Chip-Seq_LIVER_Mouse1.53631973
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.53176460
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.51967264
55E2F1_18555785_Chip-Seq_ESCs_Mouse1.49535285
56OCT4_18555785_Chip-Seq_ESCs_Mouse1.49187106
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.49068317
58ZFX_18555785_Chip-Seq_ESCs_Mouse1.48571292
59KLF5_25053715_ChIP-Seq_YYC3_Human1.48155400
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48050253
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47722197
62EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.47205216
63* TP63_22573176_ChIP-Seq_HFKS_Human1.44801074
64GATA3_24758297_ChIP-Seq_MCF-7_Human1.44473363
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44012979
66KLF4_18555785_Chip-Seq_ESCs_Mouse1.42986984
67IRF1_19129219_ChIP-ChIP_H3396_Human1.41838430
68P300_18555785_Chip-Seq_ESCs_Mouse1.41263589
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41229447
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41118044
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.41104208
72MYC_18555785_ChIP-Seq_MESCs_Mouse1.39857617
73ESRRB_18555785_Chip-Seq_ESCs_Mouse1.38948454
74PU1_27457419_Chip-Seq_LIVER_Mouse1.38476294
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36791663
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36300739
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33990507
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33602247
79SOX2_18555785_Chip-Seq_ESCs_Mouse1.32925966
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32720466
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.31599059
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30894884
83BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.30785771
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30568263
85LXR_22292898_ChIP-Seq_THP-1_Human1.30213981
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29903828
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29786671
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29715544
89P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29677860
90SMAD1_18555785_Chip-Seq_ESCs_Mouse1.28508917
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.28441689
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.27120756
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27082582
94CTCF_18555785_Chip-Seq_ESCs_Mouse1.26886943
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25927390
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.25724492
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.25581773
98* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.24700095
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23300743
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.22207394
101PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20974423
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20710660
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18664377
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18659553
105EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18198332
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17771992
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16388293
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16266316
109ERG_21242973_ChIP-ChIP_JURKAT_Human1.16260258
110ESR1_20079471_ChIP-ChIP_T-47D_Human1.16227371
111FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16225123
112RNF2_27304074_Chip-Seq_NSC_Mouse1.15926885
113SOX2_20726797_ChIP-Seq_SW620_Human1.14918065
114OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14729652
115* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13055257
116* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13055257
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12596399
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12131073
119CBX2_27304074_Chip-Seq_ESCs_Mouse1.10460939
120SMC4_20622854_ChIP-Seq_HELA_Human1.08708265
121* TCF4_18268006_ChIP-ChIP_LS174T_Human1.08199156
122POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06902772
123* GATA6_21074721_ChIP-Seq_CACO-2_Human1.06530676
124ESR1_21235772_ChIP-Seq_MCF-7_Human1.06102636
125SA1_27219007_Chip-Seq_ERYTHROID_Human1.06058101
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05796583
127GATA4_25053715_ChIP-Seq_YYC3_Human1.03445614
128* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03308220
129NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02676276
130KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01825341
131KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01825341
132KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01825341
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01670324
134TAL1_26923725_Chip-Seq_HPCs_Mouse1.01511811
135P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00749875
136MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00669429
137LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00161277
138TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00022018
139* CTCF_27219007_Chip-Seq_Bcells_Human0.99347319
140NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98736013
141UBF1/2_26484160_Chip-Seq_HMECs_Human0.98489193
142* RBPJ_21746931_ChIP-Seq_IB4_Human0.98194026
143MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97849851
144RXR_22158963_ChIP-Seq_LIVER_Mouse0.96865848
145CHD1_26751641_Chip-Seq_LNCaP_Human0.95427103
146CLOCK_20551151_ChIP-Seq_293T_Human0.93786484
147MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93301946
148Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93047447
149STAT1_17558387_ChIP-Seq_HELA_Human0.92120531
150SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90653320
151CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90171092
152GBX2_23144817_ChIP-Seq_PC3_Human0.89284806
153EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89024417
154* HNFA_21074721_ChIP-Seq_CACO-2_Human0.88691263
155EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88295393
156* PHF8_20622853_ChIP-Seq_HELA_Human0.87793890
157PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86908205
158ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86476459
159DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86033494
160* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86030962
161STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85941752
162CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85186781
163TP63_23658742_ChIP-Seq_EP156T_Human0.84516796
164SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84021938
165HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83852715
166CREB1_26743006_Chip-Seq_LNCaP_Human0.83785101
167* BCOR_27268052_Chip-Seq_Bcells_Human0.82743606
168CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81710395
169* ETV1_20927104_ChIP-Seq_GIST48_Human0.80174149
170* SA1_27219007_Chip-Seq_Bcells_Human0.79654338
171* P68_20966046_ChIP-Seq_HELA_Human0.79243520
172LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.79186261
173OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78833867
174* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78787376
175* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.78670887
176PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78453974
177P300_19829295_ChIP-Seq_ESCs_Human0.78424556
178E2F1_18555785_ChIP-Seq_MESCs_Mouse0.78265035
179NANOG_18692474_ChIP-Seq_MEFs_Mouse0.77914570
180* KAP1_27257070_Chip-Seq_ESCs_Mouse0.77670728
181LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77407075
182TP53_18474530_ChIP-ChIP_U2OS_Human0.77316164
183TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.76634147
184POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.76384353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.90437868
2MP0002796_impaired_skin_barrier3.65040673
3MP0004381_abnormal_hair_follicle3.47322666
4MP0010234_abnormal_vibrissa_follicle3.13149444
5MP0000566_synostosis3.11789185
6MP0001188_hyperpigmentation2.93146737
7MP0002098_abnormal_vibrissa_morphology2.64589703
8MP0005501_abnormal_skin_physiology2.49472716
9MP0000579_abnormal_nail_morphology2.47797344
10MP0000383_abnormal_hair_follicle2.45687530
11MP0003705_abnormal_hypodermis_morpholog2.36643630
12MP0003136_yellow_coat_color2.36446886
13MP0002277_abnormal_respiratory_mucosa2.27010701
14MP0006292_abnormal_olfactory_placode2.22739261
15MP0002254_reproductive_system_inflammat2.19262853
16MP0002132_abnormal_respiratory_system2.00645678
17MP0001216_abnormal_epidermal_layer1.99753827
18MP0003566_abnormal_cell_adhesion1.98543648
19MP0010678_abnormal_skin_adnexa1.94310010
20MP0002148_abnormal_hypersensitivity_rea1.93865361
21MP0005451_abnormal_body_composition1.91656572
22MP0002060_abnormal_skin_morphology1.89254952
23MP0010352_gastrointestinal_tract_polyps1.87528555
24MP0004782_abnormal_surfactant_physiolog1.81562821
25MP0000647_abnormal_sebaceous_gland1.72030687
26MP0008058_abnormal_DNA_repair1.63878926
27MP0003763_abnormal_thymus_physiology1.59848969
28MP0003453_abnormal_keratinocyte_physiol1.54313680
29MP0001835_abnormal_antigen_presentation1.53746886
30MP0005275_abnormal_skin_tensile1.50668102
31MP0004947_skin_inflammation1.50580458
32MP0005409_darkened_coat_color1.50277302
33MP0000427_abnormal_hair_cycle1.49157007
34MP0003315_abnormal_perineum_morphology1.47421091
35MP0004185_abnormal_adipocyte_glucose1.46576765
36MP0003878_abnormal_ear_physiology1.46453953
37MP0005377_hearing/vestibular/ear_phenot1.46453953
38MP0010771_integument_phenotype1.45513679
39MP0009785_altered_susceptibility_to1.45465523
40MP0000762_abnormal_tongue_morphology1.45443385
41MP0000490_abnormal_crypts_of1.43611283
42MP0000377_abnormal_hair_follicle1.43381296
43MP0004019_abnormal_vitamin_homeostasis1.42003623
44MP0003693_abnormal_embryo_hatching1.40668451
45MP0005671_abnormal_response_to1.39925642
46MP0004957_abnormal_blastocyst_morpholog1.39288059
47MP0008057_abnormal_DNA_replication1.37256921
48MP0009379_abnormal_foot_pigmentation1.36990884
49MP0002095_abnormal_skin_pigmentation1.36703121
50MP0005075_abnormal_melanosome_morpholog1.34926962
51MP0005023_abnormal_wound_healing1.34729376
52MP0003866_abnormal_defecation1.33367901
53MP0009697_abnormal_copulation1.32031089
54MP0000467_abnormal_esophagus_morphology1.30784542
55MP0010155_abnormal_intestine_physiology1.30594149
56MP0002009_preneoplasia1.28725076
57MP0005174_abnormal_tail_pigmentation1.26299492
58MP0000613_abnormal_salivary_gland1.26100390
59MP0001191_abnormal_skin_condition1.24418532
60MP0001666_abnormal_nutrient_absorption1.23542855
61MP0000015_abnormal_ear_pigmentation1.19634453
62MP0003786_premature_aging1.18869766
63MP0001346_abnormal_lacrimal_gland1.17185237
64MP0001790_abnormal_immune_system1.16771444
65MP0005387_immune_system_phenotype1.16771444
66MP0002163_abnormal_gland_morphology1.13773292
67MP0005367_renal/urinary_system_phenotyp1.07513208
68MP0000516_abnormal_urinary_system1.07513208
69MP0010030_abnormal_orbit_morphology1.07447639
70MP0000537_abnormal_urethra_morphology1.07106769
71MP0001986_abnormal_taste_sensitivity1.07037677
72MP0008004_abnormal_stomach_pH1.05757432
73MP0005025_abnormal_response_to1.05459815
74MP0003718_maternal_effect1.05430738
75MP0001800_abnormal_humoral_immune1.03361912
76MP0009053_abnormal_anal_canal1.02988923
77MP0004043_abnormal_pH_regulation1.02143335
78MP0000367_abnormal_coat/_hair1.02076080
79MP0000470_abnormal_stomach_morphology1.00604196
80MP0004264_abnormal_extraembryonic_tissu1.00235767
81MP0003806_abnormal_nucleotide_metabolis0.98002055
82MP0003787_abnormal_imprinting0.97759576
83MP0002234_abnormal_pharynx_morphology0.96218836
84MP0002452_abnormal_antigen_presenting0.94622076
85MP0003111_abnormal_nucleus_morphology0.94135623
86MP0002396_abnormal_hematopoietic_system0.93938071
87MP0010094_abnormal_chromosome_stability0.93788531
88MP0000678_abnormal_parathyroid_gland0.93786674
89MP0003191_abnormal_cellular_cholesterol0.93580825
90MP0005360_urolithiasis0.93118443
91MP0001873_stomach_inflammation0.93113839
92MP0001849_ear_inflammation0.92969720
93MP0005076_abnormal_cell_differentiation0.92439379
94MP0003283_abnormal_digestive_organ0.92137286
95MP0002723_abnormal_immune_serum0.91480244
96MP0008789_abnormal_olfactory_epithelium0.90898267
97MP0009931_abnormal_skin_appearance0.90242758
98MP0001919_abnormal_reproductive_system0.89513408
99MP0001819_abnormal_immune_cell0.88767119
100MP0000462_abnormal_digestive_system0.88184651
101MP0002111_abnormal_tail_morphology0.87814826
102MP0005000_abnormal_immune_tolerance0.87572148
103MP0002420_abnormal_adaptive_immunity0.86783471
104MP0008007_abnormal_cellular_replicative0.86239184
105MP0008995_early_reproductive_senescence0.85675805
106MP0005379_endocrine/exocrine_gland_phen0.84839504
107MP0002876_abnormal_thyroid_physiology0.84508678
108MP0000627_abnormal_mammary_gland0.82307001
109MP0002102_abnormal_ear_morphology0.82240251
110MP0005171_absent_coat_pigmentation0.81289807
111MP0001243_abnormal_dermal_layer0.80465609
112MP0003436_decreased_susceptibility_to0.80268255
113MP0009672_abnormal_birth_weight0.79689923
114MP0005310_abnormal_salivary_gland0.79622793
115MP0002419_abnormal_innate_immunity0.78551926
116MP0004272_abnormal_basement_membrane0.76008013
117MP0005645_abnormal_hypothalamus_physiol0.75351122
118MP0003950_abnormal_plasma_membrane0.75290482
119MP0004885_abnormal_endolymph0.75090550
120MP0000372_irregular_coat_pigmentation0.73268765
121MP0001186_pigmentation_phenotype0.71443641
122MP0000477_abnormal_intestine_morphology0.71256159
123MP0002086_abnormal_extraembryonic_tissu0.71189491
124MP0001730_embryonic_growth_arrest0.70549074
125MP0005666_abnormal_adipose_tissue0.67741209
126MP0008260_abnormal_autophagy0.66928737
127MP0001340_abnormal_eyelid_morphology0.63034067
128MP0005375_adipose_tissue_phenotype0.59635455
129MP0000465_gastrointestinal_hemorrhage0.58285596
130MP0004197_abnormal_fetal_growth/weight/0.56930730
131MP0005380_embryogenesis_phenotype0.55162826
132MP0001672_abnormal_embryogenesis/_devel0.55162826
133MP0000003_abnormal_adipose_tissue0.55157842
134MP0002697_abnormal_eye_size0.54475676
135MP0001765_abnormal_ion_homeostasis0.52383436
136MP0003755_abnormal_palate_morphology0.52008149
137MP0001851_eye_inflammation0.51640129
138MP0000350_abnormal_cell_proliferation0.50054687
139MP0003984_embryonic_growth_retardation0.49264397
140MP0003937_abnormal_limbs/digits/tail_de0.47444856
141MP0008932_abnormal_embryonic_tissue0.46636525
142MP0002085_abnormal_embryonic_tissue0.45887150
143MP0002088_abnormal_embryonic_growth/wei0.45694981
144MP0002089_abnormal_postnatal_growth/wei0.44863724
145MP0002080_prenatal_lethality0.44849350
146MP0002084_abnormal_developmental_patter0.43944704
147MP0005636_abnormal_mineral_homeostasis0.42087122
148MP0001697_abnormal_embryo_size0.41081574
149MP0001784_abnormal_fluid_regulation0.40916435
150MP0001881_abnormal_mammary_gland0.40266285
151MP0009703_decreased_birth_body0.39720222
152MP0009333_abnormal_splenocyte_physiolog0.39712994
153MP0003638_abnormal_response/metabolism_0.39229562
154MP0002249_abnormal_larynx_morphology0.39124096
155MP0003123_paternal_imprinting0.38541537

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)6.84690402
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.34311218
3Abnormal hair laboratory examination (HP:0003328)4.12959126
4Chromsome breakage (HP:0040012)4.04251108
5Abnormality of the salivary glands (HP:0010286)4.04049808
6Absent eyelashes (HP:0000561)3.65318454
7Lip pit (HP:0100267)3.50694751
8Palmoplantar keratoderma (HP:0000982)3.20255089
9Hypotrichosis (HP:0001006)3.19683093
10Plantar hyperkeratosis (HP:0007556)3.13372397
11Duplicated collecting system (HP:0000081)3.12707977
12Woolly hair (HP:0002224)3.12690753
13Sparse scalp hair (HP:0002209)3.10057030
14Palmar hyperkeratosis (HP:0010765)3.01686929
15Palmoplantar hyperkeratosis (HP:0000972)2.98607088
16Congenital ichthyosiform erythroderma (HP:0007431)2.95618726
17Increased IgE level (HP:0003212)2.95257536
18Parakeratosis (HP:0001036)2.91607361
19Abnormality of the renal collecting system (HP:0004742)2.89615445
20Abnormality of the preputium (HP:0100587)2.78753113
21Aplasia cutis congenita (HP:0001057)2.78720371
22Onycholysis (HP:0001806)2.77029868
23Distal lower limb muscle weakness (HP:0009053)2.67290834
24Absent hair (HP:0002298)2.67203127
25Cheilitis (HP:0100825)2.64553552
26Pterygium (HP:0001059)2.63186098
27Abnormality of placental membranes (HP:0011409)2.63094797
28Amniotic constriction ring (HP:0009775)2.63094797
29Prostate neoplasm (HP:0100787)2.62831371
30Thick nail (HP:0001805)2.62438091
31Ectropion (HP:0000656)2.60600111
32Alopecia of scalp (HP:0002293)2.60452546
33Advanced eruption of teeth (HP:0006288)2.59333662
34Septo-optic dysplasia (HP:0100842)2.55748407
35Fragile nails (HP:0001808)2.55181157
36Sparse eyelashes (HP:0000653)2.55089824
37Hypoplastic labia majora (HP:0000059)2.54846622
38Milia (HP:0001056)2.49635532
39Abnormality of nail color (HP:0100643)2.47922088
40Pili torti (HP:0003777)2.47262690
41Selective tooth agenesis (HP:0001592)2.46254416
42Widely patent fontanelles and sutures (HP:0004492)2.45083781
43Erythroderma (HP:0001019)2.39599057
44Right ventricular cardiomyopathy (HP:0011663)2.35325939
45Optic neuritis (HP:0100653)2.35080645
46Retrobulbar optic neuritis (HP:0100654)2.35080645
47Congenital sensorineural hearing impairment (HP:0008527)2.31875129
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.31175005
49White forelock (HP:0002211)2.29859244
50Stomach cancer (HP:0012126)2.29838576
51Ectopic kidney (HP:0000086)2.28804574
52Chronic diarrhea (HP:0002028)2.26663598
53Abnormality of the labia majora (HP:0012881)2.26553813
54Abnormality of DNA repair (HP:0003254)2.25087889
55Septate vagina (HP:0001153)2.22141219
56Anonychia (HP:0001798)2.18957435
57Alveolar cell carcinoma (HP:0006519)2.17284684
58Patchy hypopigmentation of hair (HP:0011365)2.17279184
59Brittle hair (HP:0002299)2.15508624
60Dehydration (HP:0001944)2.15412150
61Ridged nail (HP:0001807)2.14906684
62Multifactorial inheritance (HP:0001426)2.14324638
63Ventricular tachycardia (HP:0004756)2.13887954
64Upper limb muscle weakness (HP:0003484)2.12340167
65Clubbing of toes (HP:0100760)2.11341630
66Pruritus (HP:0000989)2.11190759
67Popliteal pterygium (HP:0009756)2.09380709
68Corneal erosion (HP:0200020)2.08716027
69Ankyloglossia (HP:0010296)2.06750138
70Flat capital femoral epiphysis (HP:0003370)2.06171726
71Trismus (HP:0000211)2.05216786
72Slow-growing hair (HP:0002217)2.03103457
73Abnormality of hair growth rate (HP:0011363)2.03103457
74Hyperactive renin-angiotensin system (HP:0000841)2.02895421
75Orchitis (HP:0100796)2.01468940
76Renal cortical cysts (HP:0000803)2.01418383
77Natal tooth (HP:0000695)2.00292098
78Hypohidrosis (HP:0000966)1.98314538
79Oligodontia (HP:0000677)1.97606689
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.97291003
81Gangrene (HP:0100758)1.97194454
82Curly hair (HP:0002212)1.94933347
83Eczematoid dermatitis (HP:0000976)1.94810812
84Carious teeth (HP:0000670)1.91678073
85Ureteral duplication (HP:0000073)1.90796654
86Abnormality of the gastric mucosa (HP:0004295)1.90747791
87Pustule (HP:0200039)1.90673656
88Abnormality of permanent molar morphology (HP:0011071)1.90298405
89Abnormality of the dental root (HP:0006486)1.90298405
90Taurodontia (HP:0000679)1.90298405
91Breech presentation (HP:0001623)1.89597150
92Erythema (HP:0010783)1.88898816
93Abnormality of the distal phalanx of the thumb (HP:0009617)1.88641842
94Anhidrosis (HP:0000970)1.88539007
95Atrophic scars (HP:0001075)1.88448595
96Seborrheic dermatitis (HP:0001051)1.88378884
97Abnormality of the ileum (HP:0001549)1.88354719
98Hypoplasia of dental enamel (HP:0006297)1.87876558
99Meckel diverticulum (HP:0002245)1.87626846
100Acanthosis nigricans (HP:0000956)1.86746732
101Malnutrition (HP:0004395)1.85170901
102Abnormality of incisor morphology (HP:0011063)1.84979853
103Conical tooth (HP:0000698)1.84312161
104Nail dystrophy (HP:0008404)1.84234422
105Type I transferrin isoform profile (HP:0003642)1.83731436
106Breast hypoplasia (HP:0003187)1.83161145
107Abnormal blistering of the skin (HP:0008066)1.82843306
108Reticulocytopenia (HP:0001896)1.81011910
109Premature loss of primary teeth (HP:0006323)1.80402752
110Neoplasm of the tracheobronchial system (HP:0100552)1.80169769
111Hypoplastic female external genitalia (HP:0012815)1.78356335
112Abnormal auditory evoked potentials (HP:0006958)1.78011748
113Abnormality of small intestinal villus morphology (HP:0011472)1.77999393
114Villous atrophy (HP:0011473)1.77999393
115Labial hypoplasia (HP:0000066)1.77866252
116Congenital, generalized hypertrichosis (HP:0004540)1.77514240
117Osteomalacia (HP:0002749)1.77502822
118Keratoconjunctivitis sicca (HP:0001097)1.75312291
119Abnormality of the nasal septum (HP:0000419)1.75210568
120Abnormality of the lacrimal duct (HP:0011481)1.74838493
121Dry hair (HP:0011359)1.74744404
122Squamous cell carcinoma (HP:0002860)1.72937680
123Short thumb (HP:0009778)1.72307353
124Optic nerve hypoplasia (HP:0000609)1.72006113
125Abnormality of monocarboxylic acid metabolism (HP:0010996)1.71973756
126Amelogenesis imperfecta (HP:0000705)1.71378589
127Hyperhidrosis (HP:0000975)1.70609380
128Abnormality of secondary sexual hair (HP:0009888)1.70424209
129Abnormality of the axillary hair (HP:0100134)1.70424209
130Intrahepatic cholestasis (HP:0001406)1.70117487
131Abnormality of molar (HP:0011077)1.68219216
132Abnormality of molar morphology (HP:0011070)1.68219216
133Recurrent abscess formation (HP:0002722)1.67310244
134Laryngomalacia (HP:0001601)1.66844893
135Keratoconjunctivitis (HP:0001096)1.66628891
136Increased IgM level (HP:0003496)1.66179515
137Nasolacrimal duct obstruction (HP:0000579)1.65328351
138Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65232089
139Myositis (HP:0100614)1.65181653
140Abnormality of the dental pulp (HP:0006479)1.64853054
141Fragile skin (HP:0001030)1.64644548
142Abnormality of the phalanges of the hallux (HP:0010057)1.64597428
143Blepharitis (HP:0000498)1.64146092
144Abnormality of the prostate (HP:0008775)1.63241759
145Absent eyebrow (HP:0002223)1.62387743
146Duplication of thumb phalanx (HP:0009942)1.62387294
147Autoimmune hemolytic anemia (HP:0001890)1.61187965
148Abnormality of chromosome stability (HP:0003220)1.60987754
149Abnormality of the fingernails (HP:0001231)1.58791947
150Absent thumb (HP:0009777)1.58652894
151Irregular epiphyses (HP:0010582)1.58434777
152Furrowed tongue (HP:0000221)1.57634738
153Symphalangism affecting the phalanges of the hand (HP:0009773)1.57620276
154Severe combined immunodeficiency (HP:0004430)1.55261972
155Abnormality of oral frenula (HP:0000190)1.55166832
156Abnormality of the distal phalanges of the toes (HP:0010182)1.54875471
157Abnormalities of placenta or umbilical cord (HP:0001194)1.54326498
158Focal segmental glomerulosclerosis (HP:0000097)1.50576558
159Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.50427121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.17323089
2ZAK3.20805392
3LATS13.12780067
4IRAK33.11026739
5EPHA23.02342436
6MAP3K142.96112512
7MAP3K92.84807010
8MET2.65382319
9LATS22.49899716
10TXK2.46253783
11SMG12.42776511
12AKT32.41067365
13CASK2.37199355
14MST42.31098684
15IRAK42.16292756
16STK162.11841898
17RIPK12.08194391
18EPHB22.00272557
19EIF2AK21.95171265
20SRPK11.86106355
21BLK1.83277633
22MAP3K31.80325950
23STK38L1.76640035
24MST1R1.72508943
25GRK11.71689388
26BMPR21.71612358
27PLK41.62387850
28MAP3K21.61462714
29LMTK21.56134710
30SIK11.55636479
31YES11.55109140
32MAPKAPK31.54144795
33MAP3K61.53882281
34STK241.45579328
35SIK31.40646012
36PTK21.39017920
37NUAK11.35724352
38FER1.35549248
39IKBKE1.35122237
40IKBKB1.33904958
41ADRBK21.33389685
42PAK41.32852371
43CDK31.29210284
44INSRR1.24862643
45BUB11.20805558
46BMX1.16606885
47PBK1.16180876
48FRK1.13082328
49PTK61.12746965
50TAOK21.12024676
51ERBB31.09324712
52GRK71.08989597
53TEC1.08788859
54MKNK21.07989629
55TTK1.07517869
56NME21.05942451
57BRD41.03401935
58STK391.02356266
59CHUK1.02337636
60FGFR11.01639488
61NEK61.00696751
62MAP2K60.98017190
63STK30.97661425
64NME10.96506560
65TRPM70.93373397
66TSSK60.92835715
67PIM20.90808771
68NLK0.89094730
69PRPF4B0.89079092
70MKNK10.88112640
71VRK20.87819248
72CLK10.87724626
73EEF2K0.87171125
74TESK20.84068260
75PDGFRA0.83071981
76SGK20.82841872
77IRAK10.82827259
78TGFBR10.82447127
79ARAF0.81355142
80RIPK40.80528082
81TRIB30.80478158
82PIK3CG0.79453704
83VRK10.76004629
84MAP3K120.75677919
85PRKG20.74185747
86PIK3CA0.73839900
87RPS6KB20.71335706
88ERN10.70248603
89MAP3K80.70153757
90AURKB0.69849903
91JAK30.69482832
92STK100.69200886
93ATR0.68175763
94BTK0.67012584
95STK380.66992839
96MAPK150.66794623
97MAPK70.66742989
98MAP4K10.64930512
99MUSK0.61616586
100FGFR40.61414431
101PASK0.60926544
102TNIK0.60732939
103MAP2K20.58115222
104PIM10.57971466
105CDK70.57016062
106EPHA30.56322629
107WNK40.55696763
108MTOR0.55387156
109ICK0.54742101
110IRAK20.54528940
111PRKCI0.51984419
112LRRK20.51769192
113BMPR1B0.51766650
114EPHB10.51324199
115TYK20.50219085
116PLK10.48305775
117FGR0.46784986
118BRAF0.46558032
119LYN0.46184936
120DAPK10.46160593
121MAP3K10.44625880
122TAOK10.42392412
123MAPKAPK20.40301903
124ITK0.39999834
125RPS6KA50.39248726
126ATM0.38728178
127CHEK20.36516570
128TIE10.36428059
129TBK10.34356414
130SYK0.34348706
131WEE10.34243985
132PRKCE0.34121594
133MAP2K70.33337159
134CDK120.32929429
135MAP3K70.32195744
136OXSR10.32008327
137CDK80.31945244
138KIT0.31826183
139MAP3K130.31626351
140MATK0.31522098
141BCR0.31407833
142MAPK130.30811491
143CSNK2A10.30087706
144LCK0.29953451
145CDK90.29781698
146MAPKAPK50.29759332
147MAP3K100.29007612
148EIF2AK10.28934401
149MAP2K30.28714746
150RPS6KA40.28661428
151TAF10.28381067
152CDC70.27168292
153KDR0.26775171
154CHEK10.25882473
155AKT20.25521339
156FLT30.23772345
157CSNK1E0.23611052
158AURKA0.22284881
159BRSK20.21203236
160STK40.20756901
161PKN20.20540956
162SGK2230.19643602
163SGK4940.19643602
164ABL20.19179432
165KSR20.17301318
166TYRO30.16835500
167RPS6KA20.16236433
168GRK60.16130635

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.67302861
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.29171847
3Fanconi anemia pathway_Homo sapiens_hsa034602.28756911
4Vitamin digestion and absorption_Homo sapiens_hsa049772.21099639
5Arachidonic acid metabolism_Homo sapiens_hsa005902.20831441
6Sphingolipid metabolism_Homo sapiens_hsa006002.19644878
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.06481334
8Homologous recombination_Homo sapiens_hsa034402.03745831
9RNA polymerase_Homo sapiens_hsa030201.96240328
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.90524163
11Mineral absorption_Homo sapiens_hsa049781.82499844
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.80882374
13Graft-versus-host disease_Homo sapiens_hsa053321.80345405
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79540780
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76441101
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.71066300
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70326539
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69085110
19Arginine biosynthesis_Homo sapiens_hsa002201.68802352
20Primary immunodeficiency_Homo sapiens_hsa053401.68513645
21Allograft rejection_Homo sapiens_hsa053301.65153656
22Biosynthesis of amino acids_Homo sapiens_hsa012301.64863842
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63617991
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58859867
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.56807601
26Non-homologous end-joining_Homo sapiens_hsa034501.56317806
27Sulfur relay system_Homo sapiens_hsa041221.52437178
28Phenylalanine metabolism_Homo sapiens_hsa003601.50474949
29Hematopoietic cell lineage_Homo sapiens_hsa046401.48110247
30Thyroid cancer_Homo sapiens_hsa052161.47544087
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44987370
32Tight junction_Homo sapiens_hsa045301.43982137
33Fatty acid elongation_Homo sapiens_hsa000621.42568903
34Base excision repair_Homo sapiens_hsa034101.42543994
35Arginine and proline metabolism_Homo sapiens_hsa003301.41288311
36Adherens junction_Homo sapiens_hsa045201.39995077
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.38995379
38Linoleic acid metabolism_Homo sapiens_hsa005911.37752995
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33815875
40Autoimmune thyroid disease_Homo sapiens_hsa053201.32076290
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31454281
42Renin-angiotensin system_Homo sapiens_hsa046141.31265484
43Measles_Homo sapiens_hsa051621.30424001
44Ovarian steroidogenesis_Homo sapiens_hsa049131.30322255
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30140316
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29775224
47Mismatch repair_Homo sapiens_hsa034301.28861128
48p53 signaling pathway_Homo sapiens_hsa041151.28442597
49Bladder cancer_Homo sapiens_hsa052191.25881722
50Fat digestion and absorption_Homo sapiens_hsa049751.23776002
51Herpes simplex infection_Homo sapiens_hsa051681.23686718
52One carbon pool by folate_Homo sapiens_hsa006701.21409027
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18800530
54Pyrimidine metabolism_Homo sapiens_hsa002401.18456462
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15756002
56Galactose metabolism_Homo sapiens_hsa000521.15500156
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15284784
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14444893
59Central carbon metabolism in cancer_Homo sapiens_hsa052301.13255759
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12280180
61Hippo signaling pathway_Homo sapiens_hsa043901.09138842
62Sulfur metabolism_Homo sapiens_hsa009201.08554293
63Phototransduction_Homo sapiens_hsa047441.08043872
64Basal transcription factors_Homo sapiens_hsa030221.07090484
65Histidine metabolism_Homo sapiens_hsa003401.06631024
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.06318654
67Pentose phosphate pathway_Homo sapiens_hsa000301.06176353
68Other glycan degradation_Homo sapiens_hsa005111.06047221
69Carbon metabolism_Homo sapiens_hsa012001.06035635
70DNA replication_Homo sapiens_hsa030301.04015561
71Maturity onset diabetes of the young_Homo sapiens_hsa049501.02960030
72Influenza A_Homo sapiens_hsa051641.01158810
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01127857
74Ribosome_Homo sapiens_hsa030100.97872354
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.96566288
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95002428
77ECM-receptor interaction_Homo sapiens_hsa045120.94855968
78Retinol metabolism_Homo sapiens_hsa008300.94103822
79Leishmaniasis_Homo sapiens_hsa051400.91844994
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90671601
81TNF signaling pathway_Homo sapiens_hsa046680.90402548
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.88518583
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87965149
84Legionellosis_Homo sapiens_hsa051340.87232833
85Proteasome_Homo sapiens_hsa030500.87213972
86Nucleotide excision repair_Homo sapiens_hsa034200.87142073
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.87067802
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86481266
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.85684458
90Folate biosynthesis_Homo sapiens_hsa007900.85568949
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84088721
92N-Glycan biosynthesis_Homo sapiens_hsa005100.83625913
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83565927
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82720097
95Purine metabolism_Homo sapiens_hsa002300.81352809
96Asthma_Homo sapiens_hsa053100.79711303
97Pyruvate metabolism_Homo sapiens_hsa006200.79598276
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79372365
99Fatty acid biosynthesis_Homo sapiens_hsa000610.78729689
100Hepatitis C_Homo sapiens_hsa051600.78643841
101RNA transport_Homo sapiens_hsa030130.78123308
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74093637
103Notch signaling pathway_Homo sapiens_hsa043300.73475981
104Caffeine metabolism_Homo sapiens_hsa002320.72911722
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71133349
106Ether lipid metabolism_Homo sapiens_hsa005650.70170146
107Steroid biosynthesis_Homo sapiens_hsa001000.68915638
108Starch and sucrose metabolism_Homo sapiens_hsa005000.67545798
109Apoptosis_Homo sapiens_hsa042100.67379512
110Rheumatoid arthritis_Homo sapiens_hsa053230.66220150
111African trypanosomiasis_Homo sapiens_hsa051430.65782762
112Tyrosine metabolism_Homo sapiens_hsa003500.65272956
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64885421
114PPAR signaling pathway_Homo sapiens_hsa033200.64793272
115RNA degradation_Homo sapiens_hsa030180.64630751
116Small cell lung cancer_Homo sapiens_hsa052220.63884513
117Inositol phosphate metabolism_Homo sapiens_hsa005620.62562026
118Protein digestion and absorption_Homo sapiens_hsa049740.62264116
119Hedgehog signaling pathway_Homo sapiens_hsa043400.61365030
120Pertussis_Homo sapiens_hsa051330.60848598
121MicroRNAs in cancer_Homo sapiens_hsa052060.60819172
122Fatty acid metabolism_Homo sapiens_hsa012120.59722285
123Chemical carcinogenesis_Homo sapiens_hsa052040.58500861
124Cell cycle_Homo sapiens_hsa041100.57980285
125ABC transporters_Homo sapiens_hsa020100.57431598
126Amoebiasis_Homo sapiens_hsa051460.56273033
127Basal cell carcinoma_Homo sapiens_hsa052170.56256339
128Metabolic pathways_Homo sapiens_hsa011000.56074437
129Proteoglycans in cancer_Homo sapiens_hsa052050.55537624
130Glutathione metabolism_Homo sapiens_hsa004800.54460042
131mRNA surveillance pathway_Homo sapiens_hsa030150.54014686
132Insulin signaling pathway_Homo sapiens_hsa049100.52192553
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52185520
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52078823
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51230843
136Fructose and mannose metabolism_Homo sapiens_hsa000510.50895874
137VEGF signaling pathway_Homo sapiens_hsa043700.49368701
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48987803
139Type I diabetes mellitus_Homo sapiens_hsa049400.46936536
140GnRH signaling pathway_Homo sapiens_hsa049120.44502959
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43379362
142beta-Alanine metabolism_Homo sapiens_hsa004100.42487236
143T cell receptor signaling pathway_Homo sapiens_hsa046600.42346287
144Epstein-Barr virus infection_Homo sapiens_hsa051690.41852288
145Axon guidance_Homo sapiens_hsa043600.41826865
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.41636457
147Spliceosome_Homo sapiens_hsa030400.41363848
148Toxoplasmosis_Homo sapiens_hsa051450.40756306
149Vibrio cholerae infection_Homo sapiens_hsa051100.39915652
150Malaria_Homo sapiens_hsa051440.39388329
151Bile secretion_Homo sapiens_hsa049760.39064945
152Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38930442
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35298953
154Osteoclast differentiation_Homo sapiens_hsa043800.35115356
155Tuberculosis_Homo sapiens_hsa051520.34290899

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