AIM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact5.32348172
2modulation by symbiont of host immune response (GO:0052553)5.32348172
3positive regulation by symbiont of host defense response (GO:0052509)5.32348172
4modulation by symbiont of host defense response (GO:0052031)5.32348172
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.32348172
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.32348172
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03151209
8neutrophil activation involved in immune response (GO:0002283)4.42304346
9positive regulation of gamma-delta T cell activation (GO:0046645)4.24299667
10regulation of interferon-beta biosynthetic process (GO:0045357)4.17840680
11positive regulation of interferon-alpha production (GO:0032727)4.17300585
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.15937738
13detection of other organism (GO:0098543)4.13001475
14regulation of B cell receptor signaling pathway (GO:0050855)4.06694889
15regulation of interferon-alpha production (GO:0032647)4.00284872
16macrophage activation involved in immune response (GO:0002281)3.93704667
17response to peptidoglycan (GO:0032494)3.92777563
18detection of bacterium (GO:0016045)3.92407719
19detection of molecule of bacterial origin (GO:0032490)3.88839471
20respiratory burst (GO:0045730)3.86054085
21response to host immune response (GO:0052572)3.84438635
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.84438635
23neutrophil activation (GO:0042119)3.82572988
24immunoglobulin mediated immune response (GO:0016064)3.77576545
25microglial cell activation (GO:0001774)3.71301993
26detection of external biotic stimulus (GO:0098581)3.68688820
27granulocyte activation (GO:0036230)3.68504083
28regulation of dendritic cell antigen processing and presentation (GO:0002604)3.63162679
29B cell receptor signaling pathway (GO:0050853)3.61765833
30production of molecular mediator involved in inflammatory response (GO:0002532)3.61565578
31response to interferon-alpha (GO:0035455)3.61411408
32T cell migration (GO:0072678)3.59917065
33positive regulation of type 2 immune response (GO:0002830)3.57628471
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.57368447
35negative regulation of cell killing (GO:0031342)3.57368447
36negative regulation of T cell mediated immunity (GO:0002710)3.55687363
37cellular response to interferon-gamma (GO:0071346)3.51833302
38antigen processing and presentation of endogenous antigen (GO:0019883)3.46559545
39response to type I interferon (GO:0034340)3.39813832
40myeloid cell activation involved in immune response (GO:0002275)3.39310181
41type I interferon signaling pathway (GO:0060337)3.39130008
42cellular response to type I interferon (GO:0071357)3.39130008
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.39070246
44response to host (GO:0075136)3.37708705
45response to host defenses (GO:0052200)3.37708705
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37708705
47positive regulation of antigen processing and presentation (GO:0002579)3.36974957
48positive regulation of B cell differentiation (GO:0045579)3.35261359
49superoxide anion generation (GO:0042554)3.34452831
50cellular extravasation (GO:0045123)3.33487553
51response to interleukin-15 (GO:0070672)3.33433548
52T-helper 1 type immune response (GO:0042088)3.32759179
53positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.32157469
54regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.32017611
55* response to interferon-beta (GO:0035456)3.31482688
56defense response to protozoan (GO:0042832)3.31406970
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28011074
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28011074
59response to muramyl dipeptide (GO:0032495)3.26757208
60leukocyte aggregation (GO:0070486)3.25907157
61cellular response to interleukin-15 (GO:0071350)3.23487050
62response to interferon-gamma (GO:0034341)3.22999680
63detection of biotic stimulus (GO:0009595)3.21564810
64negative thymic T cell selection (GO:0045060)3.20921890
65regulation of gamma-delta T cell differentiation (GO:0045586)3.19228825
66positive thymic T cell selection (GO:0045059)3.17961644
67positive regulation of toll-like receptor signaling pathway (GO:0034123)3.17484609
68positive regulation of interferon-beta production (GO:0032728)3.17362114
69cellular response to zinc ion (GO:0071294)3.17270792
70regulation of T cell tolerance induction (GO:0002664)3.16327709
71B cell homeostasis (GO:0001782)3.14377720
72mature B cell differentiation (GO:0002335)3.13946840
73regulation of B cell differentiation (GO:0045577)3.13744660
74regulation of alpha-beta T cell proliferation (GO:0046640)3.13069579
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.11721862
76positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.10600806
77regulation of interleukin-12 production (GO:0032655)3.10357450
78negative T cell selection (GO:0043383)3.09575473
79lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08457663
80negative regulation of B cell proliferation (GO:0030889)3.07340888
81interferon-gamma secretion (GO:0072643)3.02974820
82defense response to virus (GO:0051607)3.01132244
83cellular response to exogenous dsRNA (GO:0071360)3.01014022
84positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99981278
85myeloid dendritic cell activation (GO:0001773)2.99129328
86regulation of regulatory T cell differentiation (GO:0045589)2.99012110
87positive regulation of alpha-beta T cell proliferation (GO:0046641)2.98491260
88antigen processing and presentation via MHC class Ib (GO:0002475)2.98163492
89germinal center formation (GO:0002467)2.96936805
90regulation of mast cell degranulation (GO:0043304)2.96244070
91negative regulation of innate immune response (GO:0045824)2.94622711
92regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.93997660
93regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.93909183
94natural killer cell mediated cytotoxicity (GO:0042267)2.93583146
95natural killer cell mediated immunity (GO:0002228)2.93583146
96interferon-gamma-mediated signaling pathway (GO:0060333)2.92689357
97B cell mediated immunity (GO:0019724)2.92287278
98positive regulation of interleukin-12 production (GO:0032735)2.92163816
99negative regulation of T-helper cell differentiation (GO:0045623)2.91770941
100mast cell activation (GO:0045576)2.90969533
101regulation of activation of Janus kinase activity (GO:0010533)2.90191373
102neutrophil mediated immunity (GO:0002446)2.90040099
103response to protozoan (GO:0001562)2.89645601
104regulation of T-helper 1 cell differentiation (GO:0045625)2.89586309
105regulation of antigen processing and presentation (GO:0002577)2.88394369
106NIK/NF-kappaB signaling (GO:0038061)2.86781383
107tolerance induction (GO:0002507)2.84877563
108positive regulation of mast cell activation (GO:0033005)2.84778213
109interferon-gamma production (GO:0032609)2.84564247
110positive regulation of mast cell activation involved in immune response (GO:0033008)2.83135154
111positive regulation of mast cell degranulation (GO:0043306)2.83135154
112regulation of interleukin-12 biosynthetic process (GO:0045075)2.83093257
113regulation of mast cell activation (GO:0033003)2.82907887
114positive regulation of interleukin-17 production (GO:0032740)2.82856191
115regulation of interferon-gamma biosynthetic process (GO:0045072)2.82507744
116negative regulation of interleukin-17 production (GO:0032700)2.82083366
117negative regulation of interleukin-12 production (GO:0032695)2.81979258
118regulation of interleukin-17 production (GO:0032660)2.81288856
119positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.79096143
120macrophage activation (GO:0042116)2.78319267
121B cell proliferation (GO:0042100)2.77867216
122I-kappaB phosphorylation (GO:0007252)2.77394734
123myeloid dendritic cell differentiation (GO:0043011)2.75447469
124* cellular response to interferon-beta (GO:0035458)2.74726484
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.74599939
126dendritic cell migration (GO:0036336)2.73458395
127regulation of mast cell activation involved in immune response (GO:0033006)2.73272945
128myeloid leukocyte activation (GO:0002274)2.73129291
129dendritic cell chemotaxis (GO:0002407)2.72934301
130* positive regulation of defense response to virus by host (GO:0002230)2.72201281
131negative regulation of viral genome replication (GO:0045071)2.71789746
132regulation of gamma-delta T cell activation (GO:0046643)2.71659676
133positive regulation of isotype switching (GO:0045830)2.69989219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.42309727
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.12654719
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.79687726
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.00303869
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.83289286
6E2F7_22180533_ChIP-Seq_HELA_Human4.18611443
7* IRF8_27001747_Chip-Seq_BMDM_Mouse4.11171857
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.93122531
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.77138861
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.72403532
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.57183844
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.34215020
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.30251934
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15060473
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.82656158
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.62724110
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.62044770
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51053358
19SCL_19346495_ChIP-Seq_HPC-7_Human2.43225301
20SPI1_23547873_ChIP-Seq_NB4_Human2.38130706
21RUNX_20019798_ChIP-Seq_JUKART_Human2.22108138
22* MYB_26560356_Chip-Seq_TH2_Human2.18537294
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15190963
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03677627
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03097131
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95310582
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88820613
28* MYB_26560356_Chip-Seq_TH1_Human1.87164931
29VDR_21846776_ChIP-Seq_THP-1_Human1.84262890
30* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76946435
31VDR_24763502_ChIP-Seq_THP-1_Human1.72309738
32* PU_27001747_Chip-Seq_BMDM_Mouse1.69558911
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.68352629
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67012581
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66632323
36SPI1_23127762_ChIP-Seq_K562_Human1.61167232
37MAF_26560356_Chip-Seq_TH1_Human1.61153419
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57919901
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56498098
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52827032
41* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50631406
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.48259284
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.46093095
44VDR_24787735_ChIP-Seq_THP-1_Human1.44011683
45* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36884130
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36091725
47* CIITA_25753668_ChIP-Seq_RAJI_Human1.32947462
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30920196
49* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30172767
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29392816
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26706933
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24870014
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22421842
54UTX_26944678_Chip-Seq_JUKART_Human1.21674645
55* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21597777
56GATA3_27048872_Chip-Seq_THYMUS_Human1.20492005
57* GATA3_26560356_Chip-Seq_TH2_Human1.18438988
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18132724
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.17814916
60IRF1_19129219_ChIP-ChIP_H3396_Human1.12382183
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09885748
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09448676
63* SMRT_27268052_Chip-Seq_Bcells_Human1.06528731
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06428781
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04736867
66* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04286404
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02380328
68MYC_22102868_ChIP-Seq_BL_Human1.00493075
69VDR_23849224_ChIP-Seq_CD4+_Human0.99932425
70* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99314700
71ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99070121
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98110165
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96937506
74PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96458420
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93038563
76HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92510370
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91594476
78FLI1_27457419_Chip-Seq_LIVER_Mouse0.90485750
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90298520
80TCF7_22412390_ChIP-Seq_EML_Mouse0.89997664
81ELK1_19687146_ChIP-ChIP_HELA_Human0.88524773
82TP63_19390658_ChIP-ChIP_HaCaT_Human0.88502966
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87571972
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86624586
85ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83434987
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83390766
87MAF_26560356_Chip-Seq_TH2_Human0.82650627
88GATA3_26560356_Chip-Seq_TH1_Human0.80931357
89* NFE2_27457419_Chip-Seq_LIVER_Mouse0.78206389
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77151852
91IGF1R_20145208_ChIP-Seq_DFB_Human0.76720132
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76287444
93GATA1_22025678_ChIP-Seq_K562_Human0.76047185
94BCL6_27268052_Chip-Seq_Bcells_Human0.76035824
95EGR1_19032775_ChIP-ChIP_M12_Human0.74242081
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73562908
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72727310
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.71836499
99STAT1_20625510_ChIP-Seq_HELA_Human0.71770808
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71663860
101* EZH2_27294783_Chip-Seq_NPCs_Mouse0.71347616
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.70651049
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70015802
104* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69744217
105EGR1_23403033_ChIP-Seq_LIVER_Mouse0.69157545
106* FOXP3_21729870_ChIP-Seq_TREG_Human0.67916276
107GATA2_21666600_ChIP-Seq_HMVEC_Human0.67858177
108* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67133870
109* STAT3_18555785_Chip-Seq_ESCs_Mouse0.67075353
110* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.66226610
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.65515359
112CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.65052299
113SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.62887626
114SALL4_22934838_ChIP-ChIP_CD34+_Human0.62625099
115* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.60923747
116* NMYC_18555785_Chip-Seq_ESCs_Mouse0.60350069
117PU.1_20513432_ChIP-Seq_Bcells_Mouse0.60193964
118* PU1_27457419_Chip-Seq_LIVER_Mouse0.60045548
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59149225
120EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.57599700
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.57586135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.53586467
2MP0009785_altered_susceptibility_to3.44900429
3MP0005671_abnormal_response_to3.43680669
4MP0002148_abnormal_hypersensitivity_rea3.32535035
5MP0005000_abnormal_immune_tolerance3.29755113
6MP0001800_abnormal_humoral_immune3.20874401
7MP0001790_abnormal_immune_system3.17224128
8MP0005387_immune_system_phenotype3.17224128
9MP0003436_decreased_susceptibility_to3.12945954
10* MP0002452_abnormal_antigen_presenting2.96069811
11* MP0005025_abnormal_response_to2.91139678
12* MP0002419_abnormal_innate_immunity2.90325612
13* MP0002723_abnormal_immune_serum2.84496073
14MP0000685_abnormal_immune_system2.83806332
15MP0006082_CNS_inflammation2.73585552
16MP0003303_peritoneal_inflammation2.68920605
17* MP0001819_abnormal_immune_cell2.60700475
18* MP0002420_abnormal_adaptive_immunity2.59604120
19MP0003724_increased_susceptibility_to2.45948328
20MP0000569_abnormal_digit_pigmentation2.42881560
21MP0002396_abnormal_hematopoietic_system2.22032943
22MP0005174_abnormal_tail_pigmentation2.19489345
23MP0008057_abnormal_DNA_replication2.16105290
24MP0002398_abnormal_bone_marrow2.12105192
25MP0005464_abnormal_platelet_physiology2.09743920
26* MP0000716_abnormal_immune_system2.06572969
27MP0002405_respiratory_system_inflammati1.97038961
28MP0002006_tumorigenesis1.89707092
29MP0003763_abnormal_thymus_physiology1.88460992
30MP0010155_abnormal_intestine_physiology1.87881203
31MP0001853_heart_inflammation1.85532152
32MP0001845_abnormal_inflammatory_respons1.76692670
33MP0000689_abnormal_spleen_morphology1.76134182
34MP0005058_abnormal_lysosome_morphology1.75622443
35MP0003172_abnormal_lysosome_physiology1.75427057
36MP0002166_altered_tumor_susceptibility1.74452930
37MP0004510_myositis1.72079557
38MP0004947_skin_inflammation1.71683702
39MP0002277_abnormal_respiratory_mucosa1.70369914
40MP0009333_abnormal_splenocyte_physiolog1.68677676
41MP0005310_abnormal_salivary_gland1.67341769
42* MP0002429_abnormal_blood_cell1.66005559
43MP0002722_abnormal_immune_system1.64698812
44MP0002138_abnormal_hepatobiliary_system1.63783772
45MP0000015_abnormal_ear_pigmentation1.62657500
46MP0003448_altered_tumor_morphology1.50049256
47MP0009278_abnormal_bone_marrow1.47026796
48MP0001533_abnormal_skeleton_physiology1.46870750
49MP0001873_stomach_inflammation1.42301307
50MP0000490_abnormal_crypts_of1.37748047
51MP0009764_decreased_sensitivity_to1.37017983
52* MP0008469_abnormal_protein_level1.33596918
53MP0003183_abnormal_peptide_metabolism1.32840159
54MP0001545_abnormal_hematopoietic_system1.31543287
55MP0005397_hematopoietic_system_phenotyp1.31543287
56MP0000858_altered_metastatic_potential1.30361113
57MP0004808_abnormal_hematopoietic_stem1.25565609
58MP0000703_abnormal_thymus_morphology1.24918670
59MP0003866_abnormal_defecation1.24657067
60MP0005075_abnormal_melanosome_morpholog1.15584919
61MP0003300_gastrointestinal_ulcer1.13924979
62MP0000465_gastrointestinal_hemorrhage1.13047150
63MP0002998_abnormal_bone_remodeling1.10442884
64MP0010307_abnormal_tumor_latency1.08291222
65MP0001851_eye_inflammation1.05896823
66MP0002332_abnormal_exercise_endurance1.03251630
67MP0008058_abnormal_DNA_repair1.01969080
68MP0002933_joint_inflammation0.99415480
69MP0008877_abnormal_DNA_methylation0.98968623
70MP0003828_pulmonary_edema0.96123033
71MP0004883_abnormal_blood_vessel0.93303349
72MP0000343_altered_response_to0.91853151
73MP0003221_abnormal_cardiomyocyte_apopto0.89670787
74MP0003136_yellow_coat_color0.87461731
75MP0009765_abnormal_xenobiotic_induced0.86580774
76MP0010094_abnormal_chromosome_stability0.84872623
77MP0004381_abnormal_hair_follicle0.83601882
78MP0002095_abnormal_skin_pigmentation0.83268293
79MP0000371_diluted_coat_color0.79697272
80MP0003075_altered_response_to0.79091892
81MP0009763_increased_sensitivity_to0.75557448
82MP0002653_abnormal_ependyma_morphology0.75466785
83MP0005451_abnormal_body_composition0.74414359
84MP0001663_abnormal_digestive_system0.74243375
85MP0003191_abnormal_cellular_cholesterol0.72112605
86MP0002019_abnormal_tumor_incidence0.70988379
87MP0005164_abnormal_response_to0.68919555
88MP0005390_skeleton_phenotype0.67563176
89MP0008260_abnormal_autophagy0.67343446
90MP0002009_preneoplasia0.67105532
91MP0002132_abnormal_respiratory_system0.65981571
92MP0001986_abnormal_taste_sensitivity0.65953296
93MP0003806_abnormal_nucleotide_metabolis0.65891907
94MP0002693_abnormal_pancreas_physiology0.65123153
95MP0005166_decreased_susceptibility_to0.64854942
96MP0003077_abnormal_cell_cycle0.62576043
97MP0008004_abnormal_stomach_pH0.62137907
98MP0008874_decreased_physiological_sensi0.60331319
99MP0000604_amyloidosis0.59325477
100MP0003690_abnormal_glial_cell0.58721245
101MP0002254_reproductive_system_inflammat0.58478624
102MP0003656_abnormal_erythrocyte_physiolo0.57663269
103MP0003453_abnormal_keratinocyte_physiol0.57570199
104MP0000249_abnormal_blood_vessel0.57191074
105MP0005076_abnormal_cell_differentiation0.56876095
106MP0005167_abnormal_blood-brain_barrier0.54976572
107MP0004782_abnormal_surfactant_physiolog0.53697258
108MP0008873_increased_physiological_sensi0.52078530
109MP0002163_abnormal_gland_morphology0.49608935
110MP0002928_abnormal_bile_duct0.49253256
111MP0005266_abnormal_metabolism0.48837089
112MP0005409_darkened_coat_color0.48605669
113MP0000470_abnormal_stomach_morphology0.47958662
114MP0002136_abnormal_kidney_physiology0.47870243
115MP0003787_abnormal_imprinting0.47040242
116MP0003091_abnormal_cell_migration0.46936606
117MP0003045_fibrosis0.46821211

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.19584387
2Recurrent bacterial skin infections (HP:0005406)5.62031327
3Eczematoid dermatitis (HP:0000976)5.58087196
4Mediastinal lymphadenopathy (HP:0100721)4.25298522
5Recurrent fungal infections (HP:0002841)4.21764705
6Elevated erythrocyte sedimentation rate (HP:0003565)4.06868273
7Obstructive lung disease (HP:0006536)3.95519407
8Chronic obstructive pulmonary disease (HP:0006510)3.95519407
9Recurrent gram-negative bacterial infections (HP:0005420)3.94073024
10Recurrent skin infections (HP:0001581)3.87144875
11Gastrointestinal infarctions (HP:0005244)3.83967753
12Recurrent viral infections (HP:0004429)3.82281845
13Abnormality of macrophages (HP:0004311)3.81419309
14Myositis (HP:0100614)3.78404851
15Chronic mucocutaneous candidiasis (HP:0002728)3.68822508
16Recurrent cutaneous fungal infections (HP:0011370)3.68822508
17Vasculitis (HP:0002633)3.68091006
18Retrobulbar optic neuritis (HP:0100654)3.51200191
19Optic neuritis (HP:0100653)3.51200191
20Stomatitis (HP:0010280)3.49509771
21Meningitis (HP:0001287)3.38202238
22IgM deficiency (HP:0002850)3.33976708
23Gingivitis (HP:0000230)3.28784239
24Orchitis (HP:0100796)3.25326553
25Autoimmune thrombocytopenia (HP:0001973)3.16007697
26Vacuolated lymphocytes (HP:0001922)3.11976706
27Cellulitis (HP:0100658)3.11216186
28Prostate neoplasm (HP:0100787)3.07684216
29Chronic otitis media (HP:0000389)3.07340972
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.05697778
31Agammaglobulinemia (HP:0004432)3.05189997
32Pustule (HP:0200039)3.04136742
33Recurrent pneumonia (HP:0006532)3.03821836
34Increased IgM level (HP:0003496)3.02137392
35Chest pain (HP:0100749)2.90235014
36Gangrene (HP:0100758)2.88561168
37Periodontitis (HP:0000704)2.86149509
38Thyroiditis (HP:0100646)2.85917106
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84824797
40Chromsome breakage (HP:0040012)2.84774684
41Abnormality of the pleura (HP:0002103)2.80755545
42Pulmonary infiltrates (HP:0002113)2.73887931
43Leukocytosis (HP:0001974)2.73583671
44Eosinophilia (HP:0001880)2.69900775
45Inflammation of the large intestine (HP:0002037)2.68980943
46Abnormality of T cell number (HP:0011839)2.68072894
47Abnormality of the prostate (HP:0008775)2.67354011
48Chronic diarrhea (HP:0002028)2.67266541
49Panhypogammaglobulinemia (HP:0003139)2.65734291
50Osteomyelitis (HP:0002754)2.64072413
51Recurrent bronchitis (HP:0002837)2.60046199
52Recurrent lower respiratory tract infections (HP:0002783)2.59907124
53T lymphocytopenia (HP:0005403)2.59699669
54Basal ganglia calcification (HP:0002135)2.59303843
55Anorexia (HP:0002039)2.57542590
56Cheilitis (HP:0100825)2.52948721
57Increased neuronal autofluorescent lipopigment (HP:0002074)2.51155672
58Restrictive lung disease (HP:0002091)2.49899460
59Hypergammaglobulinemia (HP:0010702)2.48786753
60Colitis (HP:0002583)2.48781890
61Abnormality of eosinophils (HP:0001879)2.46999924
62Bronchitis (HP:0012387)2.46329466
63IgA deficiency (HP:0002720)2.46318054
64Abnormality of T cells (HP:0002843)2.45875484
65Recurrent sinusitis (HP:0011108)2.45131346
66Gastrointestinal inflammation (HP:0004386)2.44922814
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.44683810
68Lymphopenia (HP:0001888)2.44046943
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.39653376
70Keratitis (HP:0000491)2.39487984
71Agnosia (HP:0010524)2.39000622
72Petechiae (HP:0000967)2.38864323
73Gastrointestinal stroma tumor (HP:0100723)2.37687644
74Emphysema (HP:0002097)2.37070983
75Abnormality of T cell physiology (HP:0011840)2.36426842
76Granulocytopenia (HP:0001913)2.36347545
77Increased cerebral lipofuscin (HP:0011813)2.34218621
78Albinism (HP:0001022)2.33992215
79Pulmonary embolism (HP:0002204)2.32882782
80Skin rash (HP:0000988)2.31706956
81Leukopenia (HP:0001882)2.29042058
82Hemoptysis (HP:0002105)2.28154565
83Prolonged bleeding time (HP:0003010)2.27807526
84Abnormality of glycolipid metabolism (HP:0010969)2.27078923
85Abnormality of liposaccharide metabolism (HP:0010968)2.27078923
86Abnormality of glycosphingolipid metabolism (HP:0004343)2.27078923
87Encephalitis (HP:0002383)2.24740677
88IgG deficiency (HP:0004315)2.24350015
89Thrombocytosis (HP:0001894)2.24127907
90Gingival bleeding (HP:0000225)2.22246933
91Systemic lupus erythematosus (HP:0002725)2.18956730
92Verrucae (HP:0200043)2.18837994
93Papilloma (HP:0012740)2.18837994
94Abnormality of the peritoneum (HP:0002585)2.17317836
95Interstitial pulmonary disease (HP:0006530)2.15350131
96Severe combined immunodeficiency (HP:0004430)2.15081169
97Hypochromic anemia (HP:0001931)2.14774268
98Thick nail (HP:0001805)2.12655454
99Keratoconjunctivitis sicca (HP:0001097)2.11433618
100Urticaria (HP:0001025)2.11039430
101Abnormality of the fingertips (HP:0001211)2.10845133
102Lymphoma (HP:0002665)2.10683096
103Sepsis (HP:0100806)2.10533089
104Clubbing of toes (HP:0100760)2.10458211
105Premature loss of primary teeth (HP:0006323)2.06495987
106Joint swelling (HP:0001386)2.06081311
107B lymphocytopenia (HP:0010976)2.05819891
108Abnormality of B cell number (HP:0010975)2.05819891
109Combined immunodeficiency (HP:0005387)2.05737567
110Arthralgia (HP:0002829)2.05677860
111Spontaneous hematomas (HP:0007420)2.05251598
112Arterial thrombosis (HP:0004420)2.00827129
113Keratoconjunctivitis (HP:0001096)2.00035904
114Autoimmune hemolytic anemia (HP:0001890)1.99862634
115Acute hepatic failure (HP:0006554)1.98240760
116Stomach cancer (HP:0012126)1.98007085
117Skin ulcer (HP:0200042)1.97967001
118Increased IgE level (HP:0003212)1.97921728
119Disinhibition (HP:0000734)1.96907348
120Polyneuropathy (HP:0001271)1.96808671
121Chronic sinusitis (HP:0011109)1.95180713
122Viral hepatitis (HP:0006562)1.95056412
123Neutropenia (HP:0001875)1.91251603
124Neoplasm of the tracheobronchial system (HP:0100552)1.90537543
125Abnormality of the pericardium (HP:0001697)1.90226445
126Hypochromic microcytic anemia (HP:0004840)1.89814652
127Glomerulopathy (HP:0100820)1.88856598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.95717051
2MAP4K13.50368372
3TXK3.29055556
4IRAK43.26143811
5BLK3.25664942
6RIPK43.23482247
7IRAK32.63998371
8TYK22.58228747
9JAK32.27875724
10IKBKB2.26916261
11TBK12.23850071
12KIT2.21149459
13IKBKE2.19744576
14MAP3K132.03940222
15JAK12.00261361
16TEC1.89014553
17BTK1.81484145
18SYK1.73406878
19MST41.69968419
20CSF1R1.68847316
21GRK71.65652295
22CSK1.61556454
23TGFBR21.61016851
24PBK1.58414449
25FES1.55940198
26SIK21.51235389
27HCK1.50928845
28LYN1.49834263
29ITK1.49119700
30LCK1.42156019
31STK101.39304138
32EIF2AK21.38325408
33FGR1.31295791
34CHUK1.29556449
35CLK11.27965632
36ZAP701.27524747
37YES11.23957311
38TAOK31.22927863
39PIM11.22743957
40ADRBK21.16665460
41SIK31.16235206
42MATK1.14952970
43GRK61.12974950
44MAP3K111.12424064
45CDK121.12309124
46STK41.10646131
47FGFR41.07186126
48PRPF4B0.96920148
49MARK30.91947406
50BMPR20.83881880
51CAMKK20.83257055
52STK160.82968085
53CAMK1D0.81153894
54TRPM70.81030418
55NUAK10.80583149
56PRKCQ0.78737001
57BRD40.77864553
58EPHA30.75416073
59IRAK10.74200374
60GRK10.73417750
61NME20.71863867
62TLK10.69961668
63CAMK1G0.69487583
64FGFR30.68563612
65PIM20.68253591
66EPHB10.68213890
67MAPK150.68110841
68PKN10.67922436
69JAK20.67721573
70BMPR1B0.66241471
71CDK190.62042965
72RPS6KA40.61830144
73MAP3K50.58962151
74TESK20.57489696
75MKNK20.57416465
76ATR0.56069886
77MAPK110.55726814
78PRKCD0.55701437
79VRK10.55405860
80BCR0.54126488
81TAOK20.53388168
82ABL10.53356503
83PIK3CG0.52981674
84TNK20.52862261
85MAP3K10.52513054
86MOS0.51748018
87IRAK20.49573744
88FRK0.49247588
89TAOK10.46742989
90ACVR1B0.46000428
91MAP3K30.44334170
92TNIK0.44213381
93ZAK0.44175897
94PTK2B0.42490018
95EGFR0.42340604
96CDK60.42005578
97PDK10.40970511
98MAPKAPK20.39656925
99MKNK10.38518310
100RPS6KA50.38430134
101HIPK20.38317128
102MAP2K60.37915971
103KSR10.37368905
104ALK0.35933109
105NLK0.33650560
106CDK90.29956064
107KSR20.29671052
108FYN0.28660681
109TRIM280.28390393
110ERN10.27980855
111DYRK30.27851498
112CDC42BPA0.26158844
113INSR0.25929820
114MAPK70.25648981
115SGK20.25554336
116CDK40.25415375
117CDK70.24399340
118CCNB10.24156543
119PASK0.23272935
120MAP2K30.22400247
121MAP3K100.21524143
122MARK20.21492269
123EIF2AK30.21045120
124IGF1R0.21030804
125NEK90.20693100
126MAPK40.19777226
127SGK30.19612692
128CDC70.19586984
129SRPK10.19578492
130MST1R0.19415993
131PRKCZ0.19303552
132ATM0.18693415
133STK30.17385545
134LRRK20.16186712

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.75379522
2Graft-versus-host disease_Homo sapiens_hsa053322.74082131
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.68983908
4Allograft rejection_Homo sapiens_hsa053302.56383139
5Primary immunodeficiency_Homo sapiens_hsa053402.53253185
6* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.46273745
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.39931107
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35241680
9Measles_Homo sapiens_hsa051622.27346691
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.26909265
11Osteoclast differentiation_Homo sapiens_hsa043802.24163644
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.22770276
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.18094326
14B cell receptor signaling pathway_Homo sapiens_hsa046622.14126478
15Hematopoietic cell lineage_Homo sapiens_hsa046402.05101651
16Staphylococcus aureus infection_Homo sapiens_hsa051501.80303263
17Asthma_Homo sapiens_hsa053101.79457437
18Herpes simplex infection_Homo sapiens_hsa051681.75854384
19Legionellosis_Homo sapiens_hsa051341.74268468
20Influenza A_Homo sapiens_hsa051641.72920484
21Malaria_Homo sapiens_hsa051441.72813054
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69680333
23Pertussis_Homo sapiens_hsa051331.67849639
24Tuberculosis_Homo sapiens_hsa051521.63968964
25Other glycan degradation_Homo sapiens_hsa005111.62002671
26Rheumatoid arthritis_Homo sapiens_hsa053231.60559766
27Autoimmune thyroid disease_Homo sapiens_hsa053201.59535038
28Type I diabetes mellitus_Homo sapiens_hsa049401.48501359
29Antigen processing and presentation_Homo sapiens_hsa046121.47230310
30African trypanosomiasis_Homo sapiens_hsa051431.46495689
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45150474
32TNF signaling pathway_Homo sapiens_hsa046681.44667630
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.38343558
34Chemokine signaling pathway_Homo sapiens_hsa040621.36594830
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35204675
36T cell receptor signaling pathway_Homo sapiens_hsa046601.34762734
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26608322
38Non-homologous end-joining_Homo sapiens_hsa034501.26033505
39Toxoplasmosis_Homo sapiens_hsa051451.25913236
40Salmonella infection_Homo sapiens_hsa051321.20837504
41Apoptosis_Homo sapiens_hsa042101.16069436
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12244257
43Hepatitis B_Homo sapiens_hsa051611.12139767
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05518198
45Homologous recombination_Homo sapiens_hsa034401.05104342
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.02706849
47Lysosome_Homo sapiens_hsa041421.02114236
48Phagosome_Homo sapiens_hsa041450.99616109
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97649690
50Shigellosis_Homo sapiens_hsa051310.94992096
51Hepatitis C_Homo sapiens_hsa051600.92367145
52Viral myocarditis_Homo sapiens_hsa054160.88867557
53Fanconi anemia pathway_Homo sapiens_hsa034600.87371667
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.87231046
55Epstein-Barr virus infection_Homo sapiens_hsa051690.87090875
56Ribosome_Homo sapiens_hsa030100.85298814
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79122405
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76730920
59Acute myeloid leukemia_Homo sapiens_hsa052210.70334621
60Viral carcinogenesis_Homo sapiens_hsa052030.67864447
61Systemic lupus erythematosus_Homo sapiens_hsa053220.67795623
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65589757
63DNA replication_Homo sapiens_hsa030300.64891885
64Mismatch repair_Homo sapiens_hsa034300.63578160
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63398401
66Base excision repair_Homo sapiens_hsa034100.63342672
67Platelet activation_Homo sapiens_hsa046110.61204485
68Chronic myeloid leukemia_Homo sapiens_hsa052200.59376743
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54253339
70Pancreatic cancer_Homo sapiens_hsa052120.53947081
71p53 signaling pathway_Homo sapiens_hsa041150.53859991
72Notch signaling pathway_Homo sapiens_hsa043300.53010265
73Non-small cell lung cancer_Homo sapiens_hsa052230.49727758
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48175217
75Small cell lung cancer_Homo sapiens_hsa052220.47429433
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46660691
77HTLV-I infection_Homo sapiens_hsa051660.45502659
78Sphingolipid metabolism_Homo sapiens_hsa006000.45316570
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44228884
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.39837014
81VEGF signaling pathway_Homo sapiens_hsa043700.39809985
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38662815
83Prolactin signaling pathway_Homo sapiens_hsa049170.38128384
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38016599
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.36469521
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35788558
87Inositol phosphate metabolism_Homo sapiens_hsa005620.33413998
88MicroRNAs in cancer_Homo sapiens_hsa052060.32887599
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30215769
90Proteasome_Homo sapiens_hsa030500.29711535
91Amoebiasis_Homo sapiens_hsa051460.29591800
92Nucleotide excision repair_Homo sapiens_hsa034200.29542837
93Spliceosome_Homo sapiens_hsa030400.29260670
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28626452
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27943155
96Endocytosis_Homo sapiens_hsa041440.27475470
97Ether lipid metabolism_Homo sapiens_hsa005650.27072299
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26953003
99FoxO signaling pathway_Homo sapiens_hsa040680.25615185
100RNA degradation_Homo sapiens_hsa030180.25505913
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25323549
102MAPK signaling pathway_Homo sapiens_hsa040100.23745987
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.23674611
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22992462
105Dorso-ventral axis formation_Homo sapiens_hsa043200.22906675
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22051099
107HIF-1 signaling pathway_Homo sapiens_hsa040660.19436871
108Renal cell carcinoma_Homo sapiens_hsa052110.16080778
109Regulation of autophagy_Homo sapiens_hsa041400.10286577
110Type II diabetes mellitus_Homo sapiens_hsa049300.09178465
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08884148
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06033174
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.05737571
114Prostate cancer_Homo sapiens_hsa052150.03676627
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.01113717
116Insulin resistance_Homo sapiens_hsa049310.00680222
117Colorectal cancer_Homo sapiens_hsa05210-0.0286051
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0168941
119Choline metabolism in cancer_Homo sapiens_hsa05231-0.0091696
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0014719
121Ras signaling pathway_Homo sapiens_hsa04014-0.0011070

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