AIMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.62922079
2translational termination (GO:0006415)6.46559586
3ribosomal small subunit biogenesis (GO:0042274)6.42338318
4maturation of SSU-rRNA (GO:0030490)6.17702602
5ribosomal small subunit assembly (GO:0000028)6.13293062
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.71268609
7translational elongation (GO:0006414)5.67650998
8cotranslational protein targeting to membrane (GO:0006613)5.66721359
9protein targeting to ER (GO:0045047)5.61378262
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.57799768
11ribosomal large subunit biogenesis (GO:0042273)5.53947335
12ATP synthesis coupled proton transport (GO:0015986)5.37050049
13energy coupled proton transport, down electrochemical gradient (GO:0015985)5.37050049
14translational initiation (GO:0006413)5.36277040
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.36207779
16protein localization to endoplasmic reticulum (GO:0070972)5.26871572
17cellular protein complex disassembly (GO:0043624)5.19850923
18formation of translation preinitiation complex (GO:0001731)5.18078769
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.15590301
20viral life cycle (GO:0019058)5.12494262
21translation (GO:0006412)4.61636795
22ribonucleoprotein complex biogenesis (GO:0022613)4.56414800
23protein complex disassembly (GO:0043241)4.52559639
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.38194219
25macromolecular complex disassembly (GO:0032984)4.32652076
26protein complex biogenesis (GO:0070271)4.24359995
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.18565690
28proteasome assembly (GO:0043248)4.14166476
29transcription elongation from RNA polymerase III promoter (GO:0006385)4.11422208
30termination of RNA polymerase III transcription (GO:0006386)4.11422208
31mitochondrial respiratory chain complex assembly (GO:0033108)4.05933926
32establishment of integrated proviral latency (GO:0075713)4.01253341
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.91888206
34rRNA processing (GO:0006364)3.91787921
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.90630607
36negative regulation of ligase activity (GO:0051352)3.90630607
37CENP-A containing nucleosome assembly (GO:0034080)3.86749206
38cellular component biogenesis (GO:0044085)3.83459753
39nuclear-transcribed mRNA catabolic process (GO:0000956)3.82416149
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.81998090
41cullin deneddylation (GO:0010388)3.81775252
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.81733933
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.81609690
44protein neddylation (GO:0045116)3.81284781
45GTP biosynthetic process (GO:0006183)3.79366301
46DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.78996504
47rRNA metabolic process (GO:0016072)3.76888578
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.75103082
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.73972631
50regulation of cellular amino acid metabolic process (GO:0006521)3.73148026
51signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.71874409
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.71874409
53chromatin remodeling at centromere (GO:0031055)3.68325276
54signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.68219212
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.68219212
56signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.68219212
57spliceosomal snRNP assembly (GO:0000387)3.67036409
58protein targeting to membrane (GO:0006612)3.66968659
59respiratory electron transport chain (GO:0022904)3.65454520
60UTP biosynthetic process (GO:0006228)3.65127981
61signal transduction involved in DNA integrity checkpoint (GO:0072401)3.65012072
62signal transduction involved in DNA damage checkpoint (GO:0072422)3.65012072
63respiratory chain complex IV assembly (GO:0008535)3.62922037
64signal transduction involved in cell cycle checkpoint (GO:0072395)3.62670440
65protein targeting to mitochondrion (GO:0006626)3.60325903
66mRNA catabolic process (GO:0006402)3.59681851
67electron transport chain (GO:0022900)3.58747359
68transcription elongation from RNA polymerase I promoter (GO:0006362)3.52249358
69ribosome biogenesis (GO:0042254)3.52126314
707-methylguanosine mRNA capping (GO:0006370)3.51089124
71cytochrome complex assembly (GO:0017004)3.47943111
72protein deneddylation (GO:0000338)3.46948396
737-methylguanosine RNA capping (GO:0009452)3.46634834
74RNA capping (GO:0036260)3.46634834
75DNA strand elongation involved in DNA replication (GO:0006271)3.44764637
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.44627748
77water-soluble vitamin biosynthetic process (GO:0042364)3.43850842
78rRNA methylation (GO:0031167)3.41734997
79rRNA modification (GO:0000154)3.38468188
80RNA catabolic process (GO:0006401)3.38422172
81positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.38292854
82DNA deamination (GO:0045006)3.35537089
83guanosine-containing compound biosynthetic process (GO:1901070)3.35405889
84DNA replication initiation (GO:0006270)3.35163104
85regulation of mitochondrial translation (GO:0070129)3.34604597
86spliceosomal complex assembly (GO:0000245)3.34590663
87protein localization to mitochondrion (GO:0070585)3.31401004
88termination of RNA polymerase I transcription (GO:0006363)3.29713707
89DNA strand elongation (GO:0022616)3.29489730
90transcription-coupled nucleotide-excision repair (GO:0006283)3.28423652
91pseudouridine synthesis (GO:0001522)3.26768018
92DNA damage response, detection of DNA damage (GO:0042769)3.25442486
93nucleobase biosynthetic process (GO:0046112)3.24724963
94kinetochore organization (GO:0051383)3.24283635
95establishment of viral latency (GO:0019043)3.23184691
96positive regulation of ligase activity (GO:0051351)3.21909420
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.19095894
98telomere maintenance via semi-conservative replication (GO:0032201)3.17638131
99transcription from RNA polymerase I promoter (GO:0006360)3.17331902
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16741975
101tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16741975
102ribosome assembly (GO:0042255)3.15628994
103ATP biosynthetic process (GO:0006754)3.11936323
104histone exchange (GO:0043486)3.09585992
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09206523
106mitochondrial respiratory chain complex I assembly (GO:0032981)3.09206523
107NADH dehydrogenase complex assembly (GO:0010257)3.09206523
108histone mRNA metabolic process (GO:0008334)3.08633401
109inner mitochondrial membrane organization (GO:0007007)3.07788713
110DNA unwinding involved in DNA replication (GO:0006268)3.07664781
111organelle disassembly (GO:1903008)3.07094203
112hydrogen ion transmembrane transport (GO:1902600)3.06992964
113establishment of protein localization to mitochondrion (GO:0072655)3.06076577
114L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.05969971
115chaperone-mediated protein transport (GO:0072321)3.05192317
116viral mRNA export from host cell nucleus (GO:0046784)3.05176136
117regulation of ubiquitin-protein transferase activity (GO:0051438)3.05039797
118purine nucleobase biosynthetic process (GO:0009113)3.05029646
119oxidative phosphorylation (GO:0006119)3.04386458
120UTP metabolic process (GO:0046051)3.04281147
121positive regulation of cell cycle arrest (GO:0071158)3.04242677
122maturation of 5.8S rRNA (GO:0000460)3.02285713
123purine nucleoside triphosphate biosynthetic process (GO:0009145)2.96163907
124mitochondrial transport (GO:0006839)2.95489069
125peptidyl-histidine modification (GO:0018202)2.94800220
126regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.94471892
127regulation of mitotic spindle checkpoint (GO:1903504)2.94471892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.18536201
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.91120372
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.36453381
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.24644441
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.20718240
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.82735029
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77099695
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.67551268
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.49683371
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.48453964
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.45129010
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.31139599
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.20607246
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14595670
15MYC_19030024_ChIP-ChIP_MESCs_Mouse3.13583124
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.10785561
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00096936
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86343033
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.76296495
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67768597
21* VDR_23849224_ChIP-Seq_CD4+_Human2.63086397
22XRN2_22483619_ChIP-Seq_HELA_Human2.60828141
23DCP1A_22483619_ChIP-Seq_HELA_Human2.56476966
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41633780
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40438757
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34624137
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31666026
28ELK1_19687146_ChIP-ChIP_HELA_Human2.29718687
29TTF2_22483619_ChIP-Seq_HELA_Human2.29500977
30* FOXP3_21729870_ChIP-Seq_TREG_Human2.23481894
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17962264
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.98749882
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.98056171
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.97308867
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.97116312
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95593624
37GABP_19822575_ChIP-Seq_HepG2_Human1.95556344
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87257990
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.84744137
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81143559
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75532858
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71264453
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70380628
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69996454
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69243086
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61557036
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60881295
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.60059732
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58784672
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49287370
51EWS_26573619_Chip-Seq_HEK293_Human1.47528117
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.46217048
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45298316
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43717540
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42519835
56FUS_26573619_Chip-Seq_HEK293_Human1.40669929
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39014085
58AR_21909140_ChIP-Seq_LNCAP_Human1.38953918
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38887559
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35801324
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28355315
62VDR_22108803_ChIP-Seq_LS180_Human1.28148068
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27067797
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26185682
65* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26166412
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23504077
67MYC_18940864_ChIP-ChIP_HL60_Human1.23502624
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.22618256
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20402386
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19367934
71CIITA_25753668_ChIP-Seq_RAJI_Human1.18868437
72KDM5A_27292631_Chip-Seq_BREAST_Human1.18780368
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18239520
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.17536488
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13583193
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13538712
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12351963
78ZNF274_21170338_ChIP-Seq_K562_Hela1.11146880
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11133175
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09134925
81* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09129326
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08481267
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07985199
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07425545
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07425545
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07425545
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06992109
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04933149
89ELF5_23300383_ChIP-Seq_T47D_Human1.04561608
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03722652
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01960548
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.96033316
93OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93997008
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92779886
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92114100
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89055713
97TFEB_21752829_ChIP-Seq_HELA_Human0.89047456
98IRF1_19129219_ChIP-ChIP_H3396_Human0.88300641
99KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87578197
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87484858
101SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86979285
102TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85818532
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85375304
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82256819
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81320314
106SALL4_22934838_ChIP-ChIP_CD34+_Human0.81270075
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80249435
108TP63_19390658_ChIP-ChIP_HaCaT_Human0.80123050
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79940224
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79540132
111NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78222111
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.78006747
113NANOG_16153702_ChIP-ChIP_HESCs_Human0.76697193
114IGF1R_20145208_ChIP-Seq_DFB_Human0.76449750
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75669162
116CTCF_18555785_ChIP-Seq_MESCs_Mouse0.73885447
117TAF15_26573619_Chip-Seq_HEK293_Human0.73881158
118HTT_18923047_ChIP-ChIP_STHdh_Human0.73652126
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.72576484
120NANOG_18692474_ChIP-Seq_MEFs_Mouse0.71619444
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.71413088
122AR_20517297_ChIP-Seq_VCAP_Human0.71354412
123SOX2_19829295_ChIP-Seq_ESCs_Human0.70356843
124NANOG_19829295_ChIP-Seq_ESCs_Human0.70356843
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.69557487
126FOXA1_25329375_ChIP-Seq_VCAP_Human0.69464905
127FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69464905
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.68741926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.30179749
2MP0004957_abnormal_blastocyst_morpholog4.43344303
3MP0009379_abnormal_foot_pigmentation4.20539022
4MP0010094_abnormal_chromosome_stability3.47830595
5MP0003077_abnormal_cell_cycle3.10688500
6MP0008932_abnormal_embryonic_tissue3.08414118
7MP0003111_abnormal_nucleus_morphology3.07799361
8MP0008057_abnormal_DNA_replication2.92499187
9MP0008058_abnormal_DNA_repair2.88779496
10MP0003123_paternal_imprinting2.44615272
11MP0003786_premature_aging2.03213471
12MP0003136_yellow_coat_color2.01129741
13MP0003718_maternal_effect1.97557281
14MP0008877_abnormal_DNA_methylation1.97066082
15MP0003315_abnormal_perineum_morphology1.94935665
16MP0006035_abnormal_mitochondrial_morpho1.94893861
17MP0001529_abnormal_vocalization1.94581537
18MP0001730_embryonic_growth_arrest1.88053450
19MP0003806_abnormal_nucleotide_metabolis1.87154252
20MP0002638_abnormal_pupillary_reflex1.82093680
21MP0006036_abnormal_mitochondrial_physio1.77355719
22MP0004147_increased_porphyrin_level1.71854360
23MP0008007_abnormal_cellular_replicative1.69326822
24MP0002163_abnormal_gland_morphology1.69076016
25MP0004133_heterotaxia1.64836637
26MP0000350_abnormal_cell_proliferation1.54648166
27MP0003567_abnormal_fetal_cardiomyocyte1.51298863
28MP0006292_abnormal_olfactory_placode1.49682808
29MP0003950_abnormal_plasma_membrane1.48390914
30MP0000372_irregular_coat_pigmentation1.46000940
31MP0008789_abnormal_olfactory_epithelium1.43369294
32MP0001764_abnormal_homeostasis1.41119045
33MP0002006_tumorigenesis1.39971146
34MP0003941_abnormal_skin_development1.39027505
35MP0002234_abnormal_pharynx_morphology1.34692394
36MP0010030_abnormal_orbit_morphology1.32562582
37MP0004215_abnormal_myocardial_fiber1.32129444
38MP0005379_endocrine/exocrine_gland_phen1.31115659
39MP0001697_abnormal_embryo_size1.30887424
40MP0001188_hyperpigmentation1.30667492
41MP0002132_abnormal_respiratory_system1.29949660
42MP0005084_abnormal_gallbladder_morpholo1.28518995
43MP0002166_altered_tumor_susceptibility1.28301490
44MP0002938_white_spotting1.26298081
45MP0001853_heart_inflammation1.24472967
46MP0002160_abnormal_reproductive_system1.21585220
47MP0001727_abnormal_embryo_implantation1.20025648
48MP0000537_abnormal_urethra_morphology1.19363242
49MP0000358_abnormal_cell_content/1.19161572
50MP0005332_abnormal_amino_acid1.18834108
51MP0003011_delayed_dark_adaptation1.18782802
52MP0002080_prenatal_lethality1.17346073
53MP0001905_abnormal_dopamine_level1.16936206
54MP0003121_genomic_imprinting1.15775768
55MP0003186_abnormal_redox_activity1.15139953
56MP0002751_abnormal_autonomic_nervous1.14685524
57MP0001881_abnormal_mammary_gland1.11730041
58MP0000313_abnormal_cell_death1.10117879
59MP0001672_abnormal_embryogenesis/_devel1.09312054
60MP0005380_embryogenesis_phenotype1.09312054
61MP0002102_abnormal_ear_morphology1.07981679
62MP0000750_abnormal_muscle_regeneration1.07976515
63MP0000647_abnormal_sebaceous_gland1.06672955
64MP0001293_anophthalmia1.04470413
65MP0004145_abnormal_muscle_electrophysio1.04197698
66MP0000049_abnormal_middle_ear1.04081780
67MP0002085_abnormal_embryonic_tissue1.03735194
68MP0002009_preneoplasia1.02864848
69MP0000569_abnormal_digit_pigmentation1.02783221
70MP0006072_abnormal_retinal_apoptosis1.01926967
71MP0002277_abnormal_respiratory_mucosa1.00268666
72MP0002084_abnormal_developmental_patter0.97279195
73MP0002210_abnormal_sex_determination0.95756801
74MP0005174_abnormal_tail_pigmentation0.95243575
75MP0005253_abnormal_eye_physiology0.95155140
76MP0005636_abnormal_mineral_homeostasis0.94687392
77MP0006276_abnormal_autonomic_nervous0.94092495
78MP0009333_abnormal_splenocyte_physiolog0.92818039
79MP0005499_abnormal_olfactory_system0.92496328
80MP0005394_taste/olfaction_phenotype0.92496328
81MP0002837_dystrophic_cardiac_calcinosis0.91491884
82MP0002876_abnormal_thyroid_physiology0.91350677
83MP0003890_abnormal_embryonic-extraembry0.90229546
84MP0005330_cardiomyopathy0.90133376
85MP0003984_embryonic_growth_retardation0.88125057
86MP0000427_abnormal_hair_cycle0.87226277
87MP0000762_abnormal_tongue_morphology0.86923031
88MP0001986_abnormal_taste_sensitivity0.86852571
89MP0002090_abnormal_vision0.86267902
90MP0002088_abnormal_embryonic_growth/wei0.86212183
91MP0004084_abnormal_cardiac_muscle0.86035648
92MP0003195_calcinosis0.85827411
93MP0008872_abnormal_physiological_respon0.84329286
94MP0004197_abnormal_fetal_growth/weight/0.84315518
95MP0008995_early_reproductive_senescence0.84242487
96MP0001145_abnormal_male_reproductive0.84210722
97MP0000490_abnormal_crypts_of0.83846081
98MP0003937_abnormal_limbs/digits/tail_de0.83458019
99MP0008875_abnormal_xenobiotic_pharmacok0.83347409
100MP0005075_abnormal_melanosome_morpholog0.82587751
101MP0005389_reproductive_system_phenotype0.82414021
102MP0002127_abnormal_cardiovascular_syste0.81672362
103MP0003646_muscle_fatigue0.81093147
104MP0009697_abnormal_copulation0.80533809
105MP0005408_hypopigmentation0.80207993
106MP0002019_abnormal_tumor_incidence0.75625012
107MP0005266_abnormal_metabolism0.75375115
108MP0001929_abnormal_gametogenesis0.73845971
109MP0004142_abnormal_muscle_tone0.71838922
110MP0000749_muscle_degeneration0.71531396
111MP0005551_abnormal_eye_electrophysiolog0.70951583
112MP0004019_abnormal_vitamin_homeostasis0.69550778
113MP0002396_abnormal_hematopoietic_system0.69083894
114MP0000516_abnormal_urinary_system0.68844539
115MP0005367_renal/urinary_system_phenotyp0.68844539
116MP0010352_gastrointestinal_tract_polyps0.68820007
117MP0003221_abnormal_cardiomyocyte_apopto0.68661892
118MP0005501_abnormal_skin_physiology0.67669978
119MP0002095_abnormal_skin_pigmentation0.66341123
120MP0003119_abnormal_digestive_system0.66117472
121MP0001485_abnormal_pinna_reflex0.64504644
122MP0000653_abnormal_sex_gland0.64489095
123MP0004381_abnormal_hair_follicle0.64402367
124MP0005395_other_phenotype0.63467146
125MP0003938_abnormal_ear_development0.62960893
126MP0004134_abnormal_chest_morphology0.62857334
127MP0002086_abnormal_extraembryonic_tissu0.62146175
128MP0005409_darkened_coat_color0.60153731
129MP0001286_abnormal_eye_development0.59528826
130MP0003252_abnormal_bile_duct0.59445338
131MP0008873_increased_physiological_sensi0.58475037
132MP0002332_abnormal_exercise_endurance0.58315231
133MP0006054_spinal_hemorrhage0.58047245
134MP0003122_maternal_imprinting0.57910294
135MP0002233_abnormal_nose_morphology0.57472401
136MP0005410_abnormal_fertilization0.57172334
137MP0005671_abnormal_response_to0.55972556

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.33419018
2Acute necrotizing encephalopathy (HP:0006965)5.46739155
3Abnormal number of erythroid precursors (HP:0012131)5.46386688
4Reticulocytopenia (HP:0001896)5.01479318
5Abnormal mitochondria in muscle tissue (HP:0008316)4.78472275
6Mitochondrial inheritance (HP:0001427)4.65203706
7Macrocytic anemia (HP:0001972)4.38570361
8Progressive macrocephaly (HP:0004481)4.38550202
9Increased CSF lactate (HP:0002490)4.16932857
10Acute encephalopathy (HP:0006846)4.06873027
11Increased hepatocellular lipid droplets (HP:0006565)4.06302547
12Hepatocellular necrosis (HP:0001404)3.95532229
13Pallor (HP:0000980)3.69821625
14Increased serum pyruvate (HP:0003542)3.49463154
15Abnormality of glycolysis (HP:0004366)3.49463154
16Lipid accumulation in hepatocytes (HP:0006561)3.45691330
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.42142541
18Methylmalonic acidemia (HP:0002912)3.37169301
193-Methylglutaconic aciduria (HP:0003535)3.36024974
20Hepatic necrosis (HP:0002605)3.35387989
21Exercise intolerance (HP:0003546)3.16638635
22Cerebral hypomyelination (HP:0006808)3.14236633
23Increased serum lactate (HP:0002151)3.11588141
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.08777112
25Breast hypoplasia (HP:0003187)3.06596484
26Renal Fanconi syndrome (HP:0001994)3.02769996
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.99148707
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.99148707
29Abnormality of methionine metabolism (HP:0010901)2.93924323
30Birth length less than 3rd percentile (HP:0003561)2.92272265
31Cerebral edema (HP:0002181)2.83257243
32Respiratory failure (HP:0002878)2.82272201
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.78422569
34Amniotic constriction ring (HP:0009775)2.68265746
35Abnormality of placental membranes (HP:0011409)2.68265746
36Microvesicular hepatic steatosis (HP:0001414)2.67759605
37Stenosis of the external auditory canal (HP:0000402)2.67564337
38Rough bone trabeculation (HP:0100670)2.64543733
39Lethargy (HP:0001254)2.64095127
40Increased intramyocellular lipid droplets (HP:0012240)2.56184897
41Trismus (HP:0000211)2.54333669
42Exertional dyspnea (HP:0002875)2.54148556
43Respiratory difficulties (HP:0002880)2.52636878
44Oral leukoplakia (HP:0002745)2.51328956
45Lactic acidosis (HP:0003128)2.50572140
46Reduced antithrombin III activity (HP:0001976)2.50367713
47Multiple enchondromatosis (HP:0005701)2.46819738
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46630466
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.45751311
50Abnormal protein N-linked glycosylation (HP:0012347)2.45751311
51Abnormal protein glycosylation (HP:0012346)2.45751311
52Abnormal glycosylation (HP:0012345)2.45751311
53Carpal bone hypoplasia (HP:0001498)2.38401232
54Methylmalonic aciduria (HP:0012120)2.38163489
55Colon cancer (HP:0003003)2.35166510
56Optic disc pallor (HP:0000543)2.34602460
57Abnormality of serum amino acid levels (HP:0003112)2.32459703
58Chromsome breakage (HP:0040012)2.32370942
59Microretrognathia (HP:0000308)2.31234900
60Degeneration of anterior horn cells (HP:0002398)2.30591231
61Abnormality of the anterior horn cell (HP:0006802)2.30591231
62Hyperglycinemia (HP:0002154)2.30281040
63Emotional lability (HP:0000712)2.29994747
64Aplastic anemia (HP:0001915)2.29670836
65Glossoptosis (HP:0000162)2.28657369
66* Leukodystrophy (HP:0002415)2.27864554
67Pancytopenia (HP:0001876)2.22045172
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21971403
69Absent thumb (HP:0009777)2.21446497
70Type I transferrin isoform profile (HP:0003642)2.18948769
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13474136
72Abnormality of alanine metabolism (HP:0010916)2.13474136
73Hyperalaninemia (HP:0003348)2.13474136
74Facial cleft (HP:0002006)2.10203315
75Glycosuria (HP:0003076)2.08924067
76Abnormality of urine glucose concentration (HP:0011016)2.08924067
77Abnormality of vitamin B metabolism (HP:0004340)2.08133581
78Megaloblastic anemia (HP:0001889)2.05499588
79Renal cortical cysts (HP:0000803)2.03666430
80Abnormality of the preputium (HP:0100587)2.03200394
81CNS demyelination (HP:0007305)2.02887320
82Abnormal trabecular bone morphology (HP:0100671)2.02754533
83Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02489124
84Medial flaring of the eyebrow (HP:0010747)2.02361397
85X-linked dominant inheritance (HP:0001423)2.02335292
86Abnormality of the vitamin B12 metabolism (HP:0004341)2.02198344
87Generalized aminoaciduria (HP:0002909)1.99969177
88Abnormal hemoglobin (HP:0011902)1.99943091
8911 pairs of ribs (HP:0000878)1.99709089
90Selective tooth agenesis (HP:0001592)1.99211082
91Patellar aplasia (HP:0006443)1.99135594
92Secondary amenorrhea (HP:0000869)1.98091787
93Congenital, generalized hypertrichosis (HP:0004540)1.96645279
94Congenital ichthyosiform erythroderma (HP:0007431)1.96398134
95Hypoplasia of the radius (HP:0002984)1.95075409
96Premature ovarian failure (HP:0008209)1.93656949
97Abnormality of chromosome stability (HP:0003220)1.93369939
98Agnosia (HP:0010524)1.93081941
99Aplasia/Hypoplasia of the patella (HP:0006498)1.92960285
100Triphalangeal thumb (HP:0001199)1.92872481
101Molar tooth sign on MRI (HP:0002419)1.92471700
102Abnormality of midbrain morphology (HP:0002418)1.92471700
103Pancreatic cysts (HP:0001737)1.92398591
104Increased muscle lipid content (HP:0009058)1.91797156
105Sparse eyelashes (HP:0000653)1.89877975
106Abnormal lung lobation (HP:0002101)1.89744666
107Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89709126
108Premature graying of hair (HP:0002216)1.89701800
109Hypoplasia of the pons (HP:0012110)1.89157418
110Absent radius (HP:0003974)1.87563750
111Postnatal microcephaly (HP:0005484)1.84319881
112Dicarboxylic aciduria (HP:0003215)1.82853468
113Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82853468
114Delusions (HP:0000746)1.82636815
115Depressed nasal ridge (HP:0000457)1.82409179
116Abnormality of the pons (HP:0007361)1.81936583
117Aplasia/Hypoplasia of the uvula (HP:0010293)1.81790912
118Hypoglycemic coma (HP:0001325)1.81446481
119CNS hypomyelination (HP:0003429)1.80708967
120Palpitations (HP:0001962)1.80542161
121Aplasia/hypoplasia of the uterus (HP:0008684)1.78127193
122Muscle fiber atrophy (HP:0100295)1.77270699
123Type 2 muscle fiber atrophy (HP:0003554)1.77093775
124Abnormality of the umbilical cord (HP:0010881)1.75919492
125Aplasia involving forearm bones (HP:0009822)1.75157481
126Absent forearm bone (HP:0003953)1.75157481
127Meckel diverticulum (HP:0002245)1.74957349
128Abnormality of the labia minora (HP:0012880)1.74540461
129Asplenia (HP:0001746)1.73885220
130Cellular immunodeficiency (HP:0005374)1.73868514
131Irregular epiphyses (HP:0010582)1.73489789
132Cleft eyelid (HP:0000625)1.73201921
133Horseshoe kidney (HP:0000085)1.72551068
134Pancreatic fibrosis (HP:0100732)1.71892253
135Pancreatic islet-cell hyperplasia (HP:0004510)1.71806452
136B lymphocytopenia (HP:0010976)1.71359962
137Abnormality of renal resorption (HP:0011038)1.70058957
138Hyperphosphaturia (HP:0003109)1.70050101
139Upper limb muscle weakness (HP:0003484)1.69680732
140Calcaneovalgus deformity (HP:0001848)1.68818570
141Abnormality of the ileum (HP:0001549)1.67792275
142Congenital primary aphakia (HP:0007707)1.67615730
143Myelodysplasia (HP:0002863)1.67408469
144Aplasia/Hypoplasia of the spleen (HP:0010451)1.66818588
145Abnormal umbilical cord blood vessels (HP:0011403)1.65633019
146Single umbilical artery (HP:0001195)1.65633019
147Abnormality of the fetal cardiovascular system (HP:0010948)1.65633019
148Hyperinsulinemic hypoglycemia (HP:0000825)1.62761885

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.51760054
2BUB14.21922464
3NME14.01833136
4WEE13.64731636
5VRK23.61947362
6STK163.00407837
7SRPK12.73124963
8EIF2AK12.66337160
9MST42.45929799
10CDC72.43446773
11EIF2AK32.31137458
12TSSK62.24319609
13VRK12.22686644
14PASK2.15449773
15TRIM282.03048002
16ARAF2.00733942
17PLK42.00043628
18NUAK11.98146050
19PIM21.85134977
20NEK11.81018592
21TAF11.67573704
22PNCK1.63497541
23MKNK11.60278006
24BRSK21.56990625
25TLK11.55549036
26MAP4K21.55256653
27RPS6KB21.55225747
28DYRK31.54857758
29EPHA21.54352628
30TTK1.48373171
31PLK31.44585541
32PLK11.41338191
33AURKA1.40596457
34AURKB1.39825216
35BRAF1.32182955
36ACVR1B1.24337403
37PBK1.24066331
38TESK21.22165412
39NEK21.21179444
40LIMK11.20756495
41TXK1.16253218
42WNK31.14022821
43GRK51.12129888
44BCR1.10215018
45DYRK21.06245120
46OBSCN1.05751668
47ZAK1.01085340
48TGFBR10.98803543
49CDK70.98696590
50CSNK2A20.93622282
51OXSR10.92916303
52STK30.91417354
53MKNK20.91077311
54ATR0.90245810
55TESK10.88591040
56AKT30.87498330
57PAK10.86120016
58CSNK2A10.85339803
59CHEK20.85291720
60STK38L0.84234787
61WNK40.79709455
62ILK0.79468771
63PRKCI0.79369673
64CCNB10.76140242
65BRSK10.76030892
66PDK40.72833138
67PDK30.72833138
68GRK70.72245894
69PLK20.70652656
70FRK0.70299657
71EIF2AK20.69602073
72CHEK10.68690317
73PAK40.67407853
74RPS6KA50.66286057
75TEC0.64522304
76BCKDK0.64147787
77MAP3K40.62432806
78YES10.59346935
79LRRK20.59295961
80GRK60.58879167
81PDK20.58596333
82GRK10.57039098
83MYLK0.56685871
84CSNK1G10.55863278
85CDK30.54903043
86RPS6KA40.54114729
87IRAK20.53973890
88STK240.53687117
89CSNK1G30.52593985
90TNIK0.51755931
91FLT30.51746347
92MUSK0.50823838
93PIK3CA0.50396445
94MAP3K80.50225743
95SCYL20.49532382
96DAPK10.48396190
97BMPR1B0.47704029
98PIK3CG0.47396433
99DAPK30.46340674
100MAPKAPK50.45778718
101CSNK1E0.45095669
102CDK80.44547360
103INSRR0.43512231
104ADRBK20.43339994
105ERBB40.43073176
106CDK20.42486719
107UHMK10.42359271
108ABL20.42289133
109ATM0.40635408
110CDK40.40178176
111ADRBK10.38926369
112TRPM70.37331753
113BMPR20.36639580
114PINK10.35304642
115CDK10.35157910
116CLK10.34442815
117MET0.33633854
118CSNK1G20.33016174
119CDK190.32195857
120MAP3K120.32163391
121MST1R0.31687426
122MAPKAPK30.31461551
123CDK140.31263822
124MAP2K20.31135914
125PHKG20.30529238
126PHKG10.30529238
127MAP2K70.30523859
128TAOK30.29164250
129CAMK2B0.28935182
130KDR0.28904009
131RAF10.28725729
132MAP3K140.28285402
133CDK11A0.27635299
134STK40.26942068
135MELK0.25572654
136STK390.24300703
137ERBB30.23329501

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.75816782
2Proteasome_Homo sapiens_hsa030504.92059165
3RNA polymerase_Homo sapiens_hsa030203.88808926
4Oxidative phosphorylation_Homo sapiens_hsa001903.62177839
5Parkinsons disease_Homo sapiens_hsa050123.30999218
6DNA replication_Homo sapiens_hsa030303.25979752
7Mismatch repair_Homo sapiens_hsa034303.10900572
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06253012
9Spliceosome_Homo sapiens_hsa030402.89995182
10Huntingtons disease_Homo sapiens_hsa050162.57543237
11RNA transport_Homo sapiens_hsa030132.55335506
12Protein export_Homo sapiens_hsa030602.47416870
13Pyrimidine metabolism_Homo sapiens_hsa002402.42718075
14Nucleotide excision repair_Homo sapiens_hsa034202.39155416
15Homologous recombination_Homo sapiens_hsa034402.31726545
16Alzheimers disease_Homo sapiens_hsa050102.27092388
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12506063
18Base excision repair_Homo sapiens_hsa034101.87282729
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83703215
20Basal transcription factors_Homo sapiens_hsa030221.68998279
21RNA degradation_Homo sapiens_hsa030181.56182255
22Fanconi anemia pathway_Homo sapiens_hsa034601.48715580
23Non-homologous end-joining_Homo sapiens_hsa034501.45619378
24Cell cycle_Homo sapiens_hsa041101.45154315
25One carbon pool by folate_Homo sapiens_hsa006701.43780639
26Propanoate metabolism_Homo sapiens_hsa006401.41821121
27Cardiac muscle contraction_Homo sapiens_hsa042601.34830886
28Purine metabolism_Homo sapiens_hsa002301.34515119
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28417679
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17018024
31mRNA surveillance pathway_Homo sapiens_hsa030151.14749672
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11706307
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03280202
34Epstein-Barr virus infection_Homo sapiens_hsa051690.99510325
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97385618
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97349157
37p53 signaling pathway_Homo sapiens_hsa041150.90401300
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89280647
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88920587
40Systemic lupus erythematosus_Homo sapiens_hsa053220.81584069
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81167134
42Arachidonic acid metabolism_Homo sapiens_hsa005900.69669971
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67689400
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67680831
45Glutathione metabolism_Homo sapiens_hsa004800.65839006
46Selenocompound metabolism_Homo sapiens_hsa004500.63884358
47Folate biosynthesis_Homo sapiens_hsa007900.63014380
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61374457
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60602169
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.58862344
51Linoleic acid metabolism_Homo sapiens_hsa005910.57379155
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56682316
53Metabolic pathways_Homo sapiens_hsa011000.56650367
54Peroxisome_Homo sapiens_hsa041460.54657752
55Collecting duct acid secretion_Homo sapiens_hsa049660.54126167
56Butanoate metabolism_Homo sapiens_hsa006500.53147654
57Fatty acid degradation_Homo sapiens_hsa000710.52881859
58Chemical carcinogenesis_Homo sapiens_hsa052040.52092128
59Oocyte meiosis_Homo sapiens_hsa041140.49939764
60Vibrio cholerae infection_Homo sapiens_hsa051100.48189693
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.48160331
62Nitrogen metabolism_Homo sapiens_hsa009100.47671693
63Pentose phosphate pathway_Homo sapiens_hsa000300.44010260
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43191086
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.43106506
66Regulation of autophagy_Homo sapiens_hsa041400.42574736
67Tryptophan metabolism_Homo sapiens_hsa003800.40839619
68Alcoholism_Homo sapiens_hsa050340.39369457
69Carbon metabolism_Homo sapiens_hsa012000.38982296
70Antigen processing and presentation_Homo sapiens_hsa046120.38463697
71Fatty acid elongation_Homo sapiens_hsa000620.35737706
72Fatty acid metabolism_Homo sapiens_hsa012120.35426759
73Vitamin B6 metabolism_Homo sapiens_hsa007500.35118865
74Viral carcinogenesis_Homo sapiens_hsa052030.34714467
75Autoimmune thyroid disease_Homo sapiens_hsa053200.34555328
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.33461702
77Thyroid cancer_Homo sapiens_hsa052160.32290085
78Biosynthesis of amino acids_Homo sapiens_hsa012300.30503185
79Ether lipid metabolism_Homo sapiens_hsa005650.30310970
80beta-Alanine metabolism_Homo sapiens_hsa004100.29526622
81Graft-versus-host disease_Homo sapiens_hsa053320.29420078
82Fructose and mannose metabolism_Homo sapiens_hsa000510.29356002
83Vitamin digestion and absorption_Homo sapiens_hsa049770.28941200
84Retinol metabolism_Homo sapiens_hsa008300.28084563
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27834875
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27547771
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.27444414
88Sulfur relay system_Homo sapiens_hsa041220.26512649
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25918786
90Allograft rejection_Homo sapiens_hsa053300.24009702
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23301519
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.22545733
93Herpes simplex infection_Homo sapiens_hsa051680.21893328
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21243548
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20971691
96Pyruvate metabolism_Homo sapiens_hsa006200.20820054
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.20614983
98Legionellosis_Homo sapiens_hsa051340.20253301
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18506400
100HTLV-I infection_Homo sapiens_hsa051660.17935709
101Caffeine metabolism_Homo sapiens_hsa002320.17579906
102Arginine and proline metabolism_Homo sapiens_hsa003300.17537133
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16661890
104Tyrosine metabolism_Homo sapiens_hsa003500.16494870
105Basal cell carcinoma_Homo sapiens_hsa052170.16207342
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16017552
107N-Glycan biosynthesis_Homo sapiens_hsa005100.15311018
108Hedgehog signaling pathway_Homo sapiens_hsa043400.13858403
109Asthma_Homo sapiens_hsa053100.12135594
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.11393339
111Phagosome_Homo sapiens_hsa041450.11170092
112Rheumatoid arthritis_Homo sapiens_hsa053230.10595480
113Primary immunodeficiency_Homo sapiens_hsa053400.10554762
114Sphingolipid metabolism_Homo sapiens_hsa006000.09993030
115Steroid biosynthesis_Homo sapiens_hsa001000.09840097
116Hippo signaling pathway_Homo sapiens_hsa043900.09677961
117Sulfur metabolism_Homo sapiens_hsa009200.09661291
118Phenylalanine metabolism_Homo sapiens_hsa003600.08767096
119Tight junction_Homo sapiens_hsa045300.08745025
120Renin-angiotensin system_Homo sapiens_hsa046140.07687087
121Phototransduction_Homo sapiens_hsa047440.07569689
122Type I diabetes mellitus_Homo sapiens_hsa049400.07557183
123Galactose metabolism_Homo sapiens_hsa000520.07101470
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.06523742
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.02981869
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.02959255

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