ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of digestive system process (GO:0060456)	8.09328005
2	regulation of action potential (GO:0098900)	8.00644185
3	negative regulation of heart rate (GO:0010459)	7.57185533
4	positive regulation of synaptic transmission, GABAergic (GO:0032230)	7.39878923
5	positive regulation of steroid hormone secretion (GO:2000833)	6.88901784
6	regulation of glucocorticoid secretion (GO:2000849)	6.18501372
7	detection of light stimulus involved in sensory perception (GO:0050962)	5.10299778
8	detection of light stimulus involved in visual perception (GO:0050908)	5.10299778
9	regulation of corticosteroid hormone secretion (GO:2000846)	5.04336433
10	establishment of protein localization to Golgi (GO:0072600)	4.48667354
11	positive regulation of renal sodium excretion (GO:0035815)	4.44865212
12	protein targeting to Golgi (GO:0000042)	4.26061159
13	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.95968053
14	regulation of steroid hormone secretion (GO:2000831)	3.86836126
15	regulation of protein kinase A signaling (GO:0010738)	3.68019181
16	somite rostral/caudal axis specification (GO:0032525)	3.54221717
17	regulation of synaptic transmission, GABAergic (GO:0032228)	3.53397720
18	GTP biosynthetic process (GO:0006183)	3.51557778
19	protein localization to Golgi apparatus (GO:0034067)	3.46413998
20	cyclic nucleotide catabolic process (GO:0009214)	3.46251543
21	negative regulation of heart contraction (GO:0045822)	3.45097761
22	platelet dense granule organization (GO:0060155)	3.44020867
23	startle response (GO:0001964)	3.43634021
24	membrane depolarization during action potential (GO:0086010)	3.42843282
25	cAMP catabolic process (GO:0006198)	3.42511090
26	glycerophospholipid catabolic process (GO:0046475)	3.27742395
27	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.24074834
28	regulation of digestive system process (GO:0044058)	3.23547538
29	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.17340916
30	UTP metabolic process (GO:0046051)	3.16844493
31	protein polyglutamylation (GO:0018095)	3.16094539
32	presynaptic membrane assembly (GO:0097105)	3.13479610
33	cellular ketone body metabolic process (GO:0046950)	3.10538192
34	nucleoside diphosphate phosphorylation (GO:0006165)	3.08571251
35	response to isoquinoline alkaloid (GO:0014072)	3.08415273
36	water-soluble vitamin biosynthetic process (GO:0042364)	3.06203298
37	behavioral response to nicotine (GO:0035095)	3.05467366
38	keratinocyte development (GO:0003334)	3.05091490
39	positive regulation of vesicle fusion (GO:0031340)	3.02862619
40	righting reflex (GO:0060013)	3.00073283
41	presynaptic membrane organization (GO:0097090)	2.99833469
42	long-term memory (GO:0007616)	2.97885275
43	neuronal action potential propagation (GO:0019227)	2.97606498
44	calcium ion import (GO:0070509)	2.92926372
45	regulation of renal sodium excretion (GO:0035813)	2.87294588
46	inositol phosphate catabolic process (GO:0071545)	2.86436529
47	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.85880899
48	inositol phosphate dephosphorylation (GO:0046855)	2.85880899
49	UTP biosynthetic process (GO:0006228)	2.85450642
50	alanine transport (GO:0032328)	2.83514057
51	ketone body metabolic process (GO:1902224)	2.83124667
52	axonal fasciculation (GO:0007413)	2.81659293
53	response to morphine (GO:0043278)	2.80270118
54	auditory receptor cell differentiation (GO:0042491)	2.77354210
55	pyrimidine nucleobase catabolic process (GO:0006208)	2.70755399
56	proline transport (GO:0015824)	2.70203342
57	regulation of cell communication by electrical coupling (GO:0010649)	2.69948457
58	regulation of hexokinase activity (GO:1903299)	2.66989397
59	regulation of glucokinase activity (GO:0033131)	2.66989397
60	adaptation of signaling pathway (GO:0023058)	2.66854131
61	intra-Golgi vesicle-mediated transport (GO:0006891)	2.66678102
62	neuron cell-cell adhesion (GO:0007158)	2.65784380
63	Sertoli cell development (GO:0060009)	2.64059191
64	fusion of sperm to egg plasma membrane (GO:0007342)	2.64034267
65	piRNA metabolic process (GO:0034587)	2.63895242
66	neuronal action potential (GO:0019228)	2.62426678
67	detection of calcium ion (GO:0005513)	2.61091705
68	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.56475021
69	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.55622074
70	negative regulation of blood circulation (GO:1903523)	2.55401023
71	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.53258291
72	substrate-independent telencephalic tangential migration (GO:0021826)	2.53258291
73	parturition (GO:0007567)	2.53087077
74	response to pain (GO:0048265)	2.52059060
75	base-excision repair, AP site formation (GO:0006285)	2.51638827
76	L-glutamate transport (GO:0015813)	2.51547812
77	negative regulation of activin receptor signaling pathway (GO:0032926)	2.49733115
78	multicellular organism reproduction (GO:0032504)	2.48219543
79	microtubule nucleation (GO:0007020)	2.44903699
80	nucleobase catabolic process (GO:0046113)	2.44124806
81	polyol catabolic process (GO:0046174)	2.43482949
82	microtubule anchoring (GO:0034453)	2.43026548
83	regulation of clathrin-mediated endocytosis (GO:2000369)	2.42671522
84	cGMP metabolic process (GO:0046068)	2.42142102
85	inositol metabolic process (GO:0006020)	2.41656199
86	positive regulation of gastrulation (GO:2000543)	2.40934178
87	regulation of excretion (GO:0044062)	2.39896268
88	microtubule severing (GO:0051013)	2.39297857
89	response to gravity (GO:0009629)	2.38601112
90	neuron recognition (GO:0008038)	2.37907138
91	oxidative demethylation (GO:0070989)	2.37761608
92	acidic amino acid transport (GO:0015800)	2.37746848
93	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.37427151
94	synapse assembly (GO:0007416)	2.36742762
95	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.35827378
96	axoneme assembly (GO:0035082)	2.34766808
97	translesion synthesis (GO:0019985)	2.31708200
98	heparin metabolic process (GO:0030202)	2.30776115
99	positive regulation of action potential (GO:0045760)	13.0604005
100	tachykinin receptor signaling pathway (GO:0007217)	10.3502417

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.96047050
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.18338198
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.09037337
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.01246223
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.94732361
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.78901017
7	FUS_26573619_Chip-Seq_HEK293_Human	2.78051855
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.73197486
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.67147086
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.63263608
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.58221840
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.19605918
13	P300_19829295_ChIP-Seq_ESCs_Human	2.17575261
14	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.14469079
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13081662
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05924154
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.96054559
18	SMAD4_21799915_ChIP-Seq_A2780_Human	1.94558978
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.92869532
20	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.90044877
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.89524739
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.87204147
23	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.83058831
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.80070914
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.75643807
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74475348
27	VDR_22108803_ChIP-Seq_LS180_Human	1.74372476
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.68077571
29	STAT3_23295773_ChIP-Seq_U87_Human	1.67710079
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.66793568
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.62350142
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.60606913
33	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.57664098
34	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.56791742
35	TCF4_23295773_ChIP-Seq_U87_Human	1.52310044
36	EWS_26573619_Chip-Seq_HEK293_Human	1.50787823
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47147833
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45903450
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.45777210
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45017456
41	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.43321963
42	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.41238545
43	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38914305
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38887448
45	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.38724480
46	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.38506471
47	RUNX2_22187159_ChIP-Seq_PCA_Human	1.38203920
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.36554071
49	AHR_22903824_ChIP-Seq_MCF-7_Human	1.34740109
50	AR_21572438_ChIP-Seq_LNCaP_Human	1.34535836
51	AR_25329375_ChIP-Seq_VCAP_Human	1.32238752
52	TCF4_22108803_ChIP-Seq_LS180_Human	1.31282126
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.30925351
54	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.30123334
55	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.28797931
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28655951
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28655951
58	P53_22387025_ChIP-Seq_ESCs_Mouse	1.28078589
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27181342
60	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26916168
61	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26613265
62	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.24959408
63	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.24920895
64	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.24695223
65	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.24272985
66	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.23670351
67	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.21944475
68	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.20560830
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.20104780
70	CBP_20019798_ChIP-Seq_JUKART_Human	1.19701559
71	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19701559
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19338653
73	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19075832
74	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18803652
75	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18673857
76	JUN_21703547_ChIP-Seq_K562_Human	1.17522651
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17474349
78	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.15899678
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15869602
80	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.13535838
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12005046
82	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.11459847
83	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.10576847
84	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.09549757
85	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.09348556
86	P300_18555785_Chip-Seq_ESCs_Mouse	1.07705262
87	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.06399612
88	KDM2B_26808549_Chip-Seq_REH_Human	1.06007897
89	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05868113
90	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.05332448
91	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05238766
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04454068
93	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.02848462
94	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01423298
95	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.99285778
96	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.98873655
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97949457
98	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.97623670
99	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.97385393
100	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.97372257

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010386_abnormal_urinary_bladder	7.65941304
2	MP0008877_abnormal_DNA_methylation	3.22533844
3	MP0003787_abnormal_imprinting	3.07263962
4	MP0000569_abnormal_digit_pigmentation	2.95704012
5	MP0004270_analgesia	2.55421906
6	MP0003879_abnormal_hair_cell	2.52636035
7	MP0003283_abnormal_digestive_organ	2.45068883
8	MP0009046_muscle_twitch	2.33983186
9	MP0009745_abnormal_behavioral_response	2.29374633
10	MP0005174_abnormal_tail_pigmentation	2.28408331
11	MP0001486_abnormal_startle_reflex	2.21339153
12	MP0003195_calcinosis	2.15266113
13	MP0003122_maternal_imprinting	2.15247422
14	MP0002837_dystrophic_cardiac_calcinosis	2.08774796
15	MP0002064_seizures	2.07231610
16	MP0002272_abnormal_nervous_system	2.05177090
17	MP0004133_heterotaxia	1.97097277
18	MP0003121_genomic_imprinting	1.92957252
19	MP0005551_abnormal_eye_electrophysiolog	1.91012679
20	MP0009780_abnormal_chondrocyte_physiolo	1.89047958
21	MP0001968_abnormal_touch/_nociception	1.80246519
22	MP0005646_abnormal_pituitary_gland	1.77432006
23	MP0004142_abnormal_muscle_tone	1.76324052
24	MP0004742_abnormal_vestibular_system	1.69344448
25	MP0002572_abnormal_emotion/affect_behav	1.65883793
26	MP0008872_abnormal_physiological_respon	1.64411373
27	MP0000015_abnormal_ear_pigmentation	1.57373070
28	MP0002876_abnormal_thyroid_physiology	1.55273072
29	MP0003635_abnormal_synaptic_transmissio	1.53405978
30	MP0000427_abnormal_hair_cycle	1.52717791
31	MP0002184_abnormal_innervation	1.52535692
32	MP0003123_paternal_imprinting	1.47788484
33	MP0004859_abnormal_synaptic_plasticity	1.47563709
34	MP0001970_abnormal_pain_threshold	1.47187449
35	MP0003880_abnormal_central_pattern	1.45551959
36	MP0002557_abnormal_social/conspecific_i	1.43660493
37	MP0001348_abnormal_lacrimal_gland	1.43121061
38	MP0001756_abnormal_urination	1.42996290
39	MP0004885_abnormal_endolymph	1.42383872
40	MP0002638_abnormal_pupillary_reflex	1.41714165
41	MP0001984_abnormal_olfaction	1.32052601
42	MP0009379_abnormal_foot_pigmentation	1.29575657
43	MP0002734_abnormal_mechanical_nocicepti	1.29144636
44	MP0005075_abnormal_melanosome_morpholog	1.29117384
45	MP0006072_abnormal_retinal_apoptosis	1.28514385
46	MP0000778_abnormal_nervous_system	1.27637978
47	MP0005085_abnormal_gallbladder_physiolo	1.26165957
48	MP0002063_abnormal_learning/memory/cond	1.24781423
49	MP0002095_abnormal_skin_pigmentation	1.24226827
50	MP0002938_white_spotting	1.23206093
51	MP0002736_abnormal_nociception_after	1.18330787
52	MP0002090_abnormal_vision	1.16555462
53	MP0002163_abnormal_gland_morphology	1.13998482
54	MP0001986_abnormal_taste_sensitivity	1.13586080
55	MP0002067_abnormal_sensory_capabilities	1.13007037
56	MP0000516_abnormal_urinary_system	1.11906327
57	MP0005367_renal/urinary_system_phenotyp	1.11906327
58	MP0002735_abnormal_chemical_nociception	1.08653192
59	MP0001485_abnormal_pinna_reflex	1.06489143
60	MP0004043_abnormal_pH_regulation	1.06022559
61	MP0003011_delayed_dark_adaptation	1.05524045
62	MP0002909_abnormal_adrenal_gland	1.05422500
63	MP0001919_abnormal_reproductive_system	1.05338691
64	MP0004019_abnormal_vitamin_homeostasis	1.04863205
65	MP0005645_abnormal_hypothalamus_physiol	1.04323406
66	MP0008875_abnormal_xenobiotic_pharmacok	1.01748774
67	MP0005084_abnormal_gallbladder_morpholo	1.00995140
68	MP0004145_abnormal_muscle_electrophysio	0.99037552
69	MP0004381_abnormal_hair_follicle	0.98302623
70	MP0000538_abnormal_urinary_bladder	0.97788526
71	MP0002229_neurodegeneration	0.97347723
72	MP0000631_abnormal_neuroendocrine_gland	0.97119353
73	MP0005379_endocrine/exocrine_gland_phen	0.94529106
74	MP0001501_abnormal_sleep_pattern	0.91173015
75	MP0002693_abnormal_pancreas_physiology	0.90472163
76	MP0001944_abnormal_pancreas_morphology	0.89053994
77	MP0002751_abnormal_autonomic_nervous	0.88403825
78	MP0005636_abnormal_mineral_homeostasis	0.86324417
79	MP0004924_abnormal_behavior	0.85894425
80	MP0005386_behavior/neurological_phenoty	0.85894425
81	MP0002882_abnormal_neuron_morphology	0.85351222
82	MP0002752_abnormal_somatic_nervous	0.82681898
83	MP0000026_abnormal_inner_ear	0.79805472
84	MP0002066_abnormal_motor_capabilities/c	0.79356572
85	MP0002138_abnormal_hepatobiliary_system	0.78521832
86	MP0001905_abnormal_dopamine_level	0.77510258
87	MP0003119_abnormal_digestive_system	0.76974095
88	MP0005083_abnormal_biliary_tract	0.76903146
89	MP0005253_abnormal_eye_physiology	0.76313763
90	MP0005408_hypopigmentation	0.76024805
91	MP0005266_abnormal_metabolism	0.74821121
92	MP0005365_abnormal_bile_salt	0.74793969
93	MP0002733_abnormal_thermal_nociception	0.74372307
94	MP0005332_abnormal_amino_acid	0.71751110
95	MP0001440_abnormal_grooming_behavior	0.71155640
96	MP0008961_abnormal_basal_metabolism	0.71076692
97	MP0003172_abnormal_lysosome_physiology	0.70407948
98	MP0003252_abnormal_bile_duct	0.68592116
99	MP0000639_abnormal_adrenal_gland	0.66584751
100	MP0002928_abnormal_bile_duct	0.66533229

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	5.70838242
2	Albinism (HP:0001022)	4.67393117
3	Renal cortical cysts (HP:0000803)	4.62153474
4	Abnormal rod and cone electroretinograms (HP:0008323)	4.45290359
5	Hypoplasia of the fovea (HP:0007750)	4.34797789
6	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.34797789
7	Broad-based gait (HP:0002136)	4.23932222
8	Aplasia/Hypoplasia of the tibia (HP:0005772)	4.14438216
9	Hyperventilation (HP:0002883)	3.76798087
10	Abnormality of macular pigmentation (HP:0008002)	3.71593220
11	Hip dysplasia (HP:0001385)	3.68190221
12	Short tibia (HP:0005736)	3.66697214
13	Abnormality of the fovea (HP:0000493)	3.55278391
14	Molar tooth sign on MRI (HP:0002419)	3.48971709
15	Abnormality of midbrain morphology (HP:0002418)	3.48971709
16	Abnormality of the renal cortex (HP:0011035)	3.40838736
17	Limb dystonia (HP:0002451)	3.11066154
18	Hypoglycemic coma (HP:0001325)	3.01812894
19	Nephronophthisis (HP:0000090)	2.99753962
20	Febrile seizures (HP:0002373)	2.98385240
21	Proximal tubulopathy (HP:0000114)	2.92531405
22	Pancreatic fibrosis (HP:0100732)	2.88772752
23	Severe visual impairment (HP:0001141)	2.84109842
24	Aplasia/Hypoplasia of the macula (HP:0008059)	2.81361804
25	Rib fusion (HP:0000902)	2.77356841
26	Pancreatic cysts (HP:0001737)	2.75529891
27	Polyphagia (HP:0002591)	2.74328438
28	Protruding tongue (HP:0010808)	2.74199510
29	Generalized hypopigmentation (HP:0007513)	2.66533116
30	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.63764730
31	Calf muscle hypertrophy (HP:0008981)	2.59603878
32	Thoracolumbar scoliosis (HP:0002944)	2.54966116
33	Colon cancer (HP:0003003)	2.47539538
34	Gaze-evoked nystagmus (HP:0000640)	2.44810196
35	Agitation (HP:0000713)	2.44780056
36	Abnormality of the renal medulla (HP:0100957)	2.40046533
37	Hepatic necrosis (HP:0002605)	2.38789619
38	Muscle hypertrophy of the lower extremities (HP:0008968)	2.35955185
39	Epileptic encephalopathy (HP:0200134)	2.29533180
40	Glycosuria (HP:0003076)	2.26306057
41	Abnormality of urine glucose concentration (HP:0011016)	2.26306057
42	True hermaphroditism (HP:0010459)	2.24255030
43	Focal motor seizures (HP:0011153)	2.23925566
44	Large for gestational age (HP:0001520)	2.20664741
45	Intestinal atresia (HP:0011100)	2.19997457
46	Drooling (HP:0002307)	2.17888574
47	Medial flaring of the eyebrow (HP:0010747)	2.17864812
48	Inappropriate behavior (HP:0000719)	2.17122687
49	Attenuation of retinal blood vessels (HP:0007843)	2.16502203
50	Generalized aminoaciduria (HP:0002909)	2.16364706
51	Abnormality of the corticospinal tract (HP:0002492)	2.05875764
52	Central scotoma (HP:0000603)	2.05098968
53	Gait imbalance (HP:0002141)	2.02167958
54	Enlarged epiphyses (HP:0010580)	2.02016581
55	Fair hair (HP:0002286)	1.98868645
56	Hypoplastic ischia (HP:0003175)	1.98852356
57	EEG with generalized epileptiform discharges (HP:0011198)	1.97584895
58	Excessive salivation (HP:0003781)	1.96374645
59	Hypsarrhythmia (HP:0002521)	1.95392447
60	Hemiparesis (HP:0001269)	1.95044010
61	Fibular aplasia (HP:0002990)	1.93853244
62	Increased hepatocellular lipid droplets (HP:0006565)	1.92990888
63	Epidermoid cyst (HP:0200040)	1.91183373
64	Epileptiform EEG discharges (HP:0011182)	1.90245623
65	Amyotrophic lateral sclerosis (HP:0007354)	1.88433406
66	Lissencephaly (HP:0001339)	1.86635023
67	Pachygyria (HP:0001302)	1.85374513
68	Aplasia/hypoplasia of the uterus (HP:0008684)	1.82680440
69	Postaxial foot polydactyly (HP:0001830)	1.81629662
70	Lipid accumulation in hepatocytes (HP:0006561)	1.80880361
71	Sclerocornea (HP:0000647)	1.79439431
72	Hypoplasia of the uterus (HP:0000013)	1.77125706
73	Mitochondrial inheritance (HP:0001427)	1.76165402
74	Increased CSF lactate (HP:0002490)	1.74418501
75	Shawl scrotum (HP:0000049)	1.73422265
76	Hepatocellular necrosis (HP:0001404)	1.73114091
77	Abnormality of lateral ventricle (HP:0030047)	1.72018918
78	Thyroid-stimulating hormone excess (HP:0002925)	1.71511822
79	Small hand (HP:0200055)	1.70610003
80	Severe muscular hypotonia (HP:0006829)	1.69841090
81	Progressive cerebellar ataxia (HP:0002073)	1.69804032
82	Pendular nystagmus (HP:0012043)	1.69478809
83	Tented upper lip vermilion (HP:0010804)	1.69180635
84	Abnormal albumin level (HP:0012116)	1.68683870
85	Hypoalbuminemia (HP:0003073)	1.68683870
86	Astrocytoma (HP:0009592)	1.68594484
87	Abnormality of the astrocytes (HP:0100707)	1.68594484
88	Abnormality of the ischium (HP:0003174)	1.68343360
89	Disproportionate short-trunk short stature (HP:0003521)	1.68202679
90	Median cleft lip (HP:0000161)	1.68168894
91	Osteomalacia (HP:0002749)	1.66595527
92	Progressive macrocephaly (HP:0004481)	1.66534171
93	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.66429641
94	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.66429641
95	Postaxial hand polydactyly (HP:0001162)	1.66080692
96	Difficulty running (HP:0009046)	1.65469806
97	Disinhibition (HP:0000734)	1.64856893
98	Focal seizures (HP:0007359)	1.64201352
99	Hyperglycemia (HP:0003074)	1.63540896
100	Acute necrotizing encephalopathy (HP:0006965)	1.63518863

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	6.00797907
2	FRK	4.26274111
3	CASK	3.60243147
4	NTRK3	3.45039733
5	PKN2	3.35934060
6	MAP3K4	2.68764309
7	FLT3	2.54420938
8	MAP2K7	2.46725016
9	MARK1	2.34903228
10	MAPK13	2.31483754
11	PHKG2	2.27677082
12	PHKG1	2.27677082
13	STK24	2.20398759
14	DAPK2	2.08273770
15	ZAK	2.02590440
16	ADRBK2	1.93159234
17	PINK1	1.82502332
18	TNIK	1.73330302
19	BMPR1B	1.72455244
20	SIK2	1.65333739
21	TAF1	1.63566547
22	PAK3	1.53389562
23	WNK4	1.52683175
24	GRK1	1.44534265
25	BRD4	1.41799132
26	MKNK2	1.31366083
27	ACVR1B	1.10171443
28	STK3	1.07584812
29	PRKCE	0.99830905
30	MAP2K4	0.99358392
31	PIK3CA	0.97757703
32	OXSR1	0.95241874
33	PNCK	0.89290291
34	STK38L	0.87248898
35	WNK3	0.86527951
36	INSRR	0.83183087
37	DYRK3	0.82531250
38	TAOK1	0.81388850
39	DMPK	0.81191185
40	NUAK1	0.78703024
41	PRKD3	0.75196968
42	STK16	0.73811262
43	PRKD2	0.73717822
44	PRKCG	0.69754691
45	STK11	0.69278067
46	SGK2	0.67437176
47	GRK7	0.66389310
48	PRKG1	0.64570272
49	RPS6KA2	0.63221465
50	MUSK	0.60649624
51	DAPK1	0.59549679
52	OBSCN	0.59267004
53	TRPM7	0.58620225
54	STK39	0.58596239
55	CAMK4	0.53115233
56	CAMK1	0.52287613
57	LMTK2	0.52211257
58	DYRK2	0.52187078
59	SGK494	0.51526928
60	SGK223	0.51526928
61	TNK2	0.51306680
62	PRKCZ	0.50564527
63	UHMK1	0.50175603
64	RPS6KA4	0.48858567
65	CDK5	0.48653759
66	TIE1	0.48172175
67	RPS6KB1	0.47529857
68	NTRK2	0.47085153
69	CAMKK2	0.46858047
70	PRKACA	0.46536627
71	ADRBK1	0.45925498
72	STK4	0.45437088
73	CSNK1A1	0.45356267
74	CAMK2A	0.43793090
75	CSNK1G2	0.43674588
76	EPHA4	0.42893785
77	PAK6	0.42521118
78	ROCK1	0.41908275
79	GRK5	0.41282290
80	PRKCI	0.40937086
81	DYRK1A	0.40883154
82	CAMK2D	0.40716897
83	TXK	0.40057986
84	PRKACB	0.38618985
85	EPHB2	0.36501666
86	PTK2B	0.33274088
87	ATR	0.33150808
88	CSNK1G1	0.32198522
89	PKN1	0.32049219
90	PRKCH	0.31991765
91	SGK3	0.31289100
92	BCR	0.30944241
93	CAMK1G	0.30786415
94	MAP3K7	0.28336756
95	NME1	0.28146419
96	MAP3K11	0.28049310
97	PLK2	0.27347659
98	MARK2	0.26586412
99	FGFR1	0.25548010
100	MAPKAPK3	0.25370374

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.28080008
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.99185599
3	Sulfur metabolism_Homo sapiens_hsa00920	2.93858708
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.63910317
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.57270699
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.43291277
7	Insulin secretion_Homo sapiens_hsa04911	2.27048522
8	Butanoate metabolism_Homo sapiens_hsa00650	2.20345344
9	Taste transduction_Homo sapiens_hsa04742	2.05703886
10	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.93789228
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.79298659
12	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.77515312
13	Phototransduction_Homo sapiens_hsa04744	1.74629458
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.74103614
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.71526642
16	Glutamatergic synapse_Homo sapiens_hsa04724	1.71400273
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.66507331
18	Protein export_Homo sapiens_hsa03060	1.62277950
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.61730757
20	Folate biosynthesis_Homo sapiens_hsa00790	1.59686059
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.55601442
22	GABAergic synapse_Homo sapiens_hsa04727	1.55093299
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.48850636
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.47226067
25	Caffeine metabolism_Homo sapiens_hsa00232	1.43748548
26	Morphine addiction_Homo sapiens_hsa05032	1.43352741
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.41009212
28	Circadian entrainment_Homo sapiens_hsa04713	1.36844471
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.32056426
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.31858613
31	Basal transcription factors_Homo sapiens_hsa03022	1.31359677
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.30228364
33	Renin secretion_Homo sapiens_hsa04924	1.29991402
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.26442996
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.25910924
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.20607208
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.18065871
38	Type II diabetes mellitus_Homo sapiens_hsa04930	1.14887062
39	Peroxisome_Homo sapiens_hsa04146	1.14026997
40	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.12507384
41	Calcium signaling pathway_Homo sapiens_hsa04020	1.12335022
42	ABC transporters_Homo sapiens_hsa02010	1.12085905
43	Alzheimers disease_Homo sapiens_hsa05010	1.10363879
44	Mineral absorption_Homo sapiens_hsa04978	1.09263106
45	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.08416247
46	Parkinsons disease_Homo sapiens_hsa05012	1.05558660
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.04136694
48	Salivary secretion_Homo sapiens_hsa04970	1.02714880
49	Serotonergic synapse_Homo sapiens_hsa04726	1.01192558
50	Regulation of autophagy_Homo sapiens_hsa04140	0.98489920
51	Olfactory transduction_Homo sapiens_hsa04740	0.98290680
52	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.94195994
53	Retinol metabolism_Homo sapiens_hsa00830	0.93804330
54	Fatty acid degradation_Homo sapiens_hsa00071	0.93308097
55	Circadian rhythm_Homo sapiens_hsa04710	0.92103347
56	Histidine metabolism_Homo sapiens_hsa00340	0.90120567
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89860579
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.88093101
59	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.84867010
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81788757
61	Cholinergic synapse_Homo sapiens_hsa04725	0.80618874
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.80025213
63	Huntingtons disease_Homo sapiens_hsa05016	0.77789542
64	Amphetamine addiction_Homo sapiens_hsa05031	0.77260537
65	Bile secretion_Homo sapiens_hsa04976	0.75698243
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.75218085
67	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.74950470
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.73343144
69	Sphingolipid metabolism_Homo sapiens_hsa00600	0.73244591
70	RNA polymerase_Homo sapiens_hsa03020	0.72459075
71	RNA degradation_Homo sapiens_hsa03018	0.68413367
72	cAMP signaling pathway_Homo sapiens_hsa04024	0.68351206
73	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.67334469
74	Axon guidance_Homo sapiens_hsa04360	0.66445610
75	Long-term depression_Homo sapiens_hsa04730	0.65667380
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64964369
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.64898103
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.64285704
79	Lysine degradation_Homo sapiens_hsa00310	0.64248185
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.63778386
81	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.62874827
82	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.62106050
83	Homologous recombination_Homo sapiens_hsa03440	0.61171336
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59185685
85	Pancreatic secretion_Homo sapiens_hsa04972	0.58768716
86	Purine metabolism_Homo sapiens_hsa00230	0.56982773
87	Gastric acid secretion_Homo sapiens_hsa04971	0.56797554
88	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.56011792
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.55261289
90	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.54224867
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53935749
92	Fatty acid elongation_Homo sapiens_hsa00062	0.52341265
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51438576
94	Metabolic pathways_Homo sapiens_hsa01100	0.50691742
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50024399
96	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.49541623
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47657804
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.46053495
99	Fanconi anemia pathway_Homo sapiens_hsa03460	0.45190136
100	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.44153679

AIMP1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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